MCID: THY094
MIFTS: 46

Thyroid Carcinoma, Papillary malady

Genetic diseases, Rare diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Thyroid Carcinoma, Papillary

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Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Thyroid Carcinoma, Papillary, Aliases & Descriptions:

Name: Thyroid Carcinoma, Papillary 45 10
Papillary Thyroid Carcinoma 9 41 11 60
Papillary or Follicular Thyroid Carcinoma 41 47
Well-Differentiated Thyroid Carcinoma 41 47
Thyroid Papillary Carcinoma 45 43
Papillary Thyroid Cancer 43 22
 
Familial Nonmedullary Thyroid Cancer, Papillary 41
Nonmedullary Thyroid Carcinoma, Papillary 41
Papillary Carcinoma of the Thyroid Gland 9
Differentiated Thyroid Gland Carcinoma 60
Thyroid Carcinoma, Papillary, Somatic 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
papillary or follicular thyroid carcinoma:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Europe); Age of onset: Adult


External Ids:

OMIM45 188550
Disease Ontology9 DOID:3969
NCIt38 C4035
MeSH33 C536915
SNOMED-CT55 4797003, 255029007
Orphanet47 146
ICD10 via Orphanet26 C73
UMLS via Orphanet61 C0238463

Summaries for Thyroid Carcinoma, Papillary

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OMIM:45 Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95%... (188550) more...

MalaCards based summary: Thyroid Carcinoma, Papillary, also known as papillary thyroid carcinoma, is related to struma ovarii and multiple endocrine neoplasia, and has symptoms including autosomal dominant inheritanceand papillary thyroid carcinoma. An important gene associated with Thyroid Carcinoma, Papillary is TRIM24 (tripartite motif containing 24), and among its related pathways are Development HGF signaling pathway and Signaling by FGFR. The compounds cipa and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include thyroid and lymph node, and related mouse phenotypes are normal and tumorigenesis.

Disease Ontology:9 A thyroid carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer.

Wikipedia:63 Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer,... more...

Related Diseases for Thyroid Carcinoma, Papillary

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Diseases in the Thyroid Carcinoma, Papillary family:

Familial Papillary Thyroid Carcinoma

Diseases related to Thyroid Carcinoma, Papillary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1struma ovarii31.6NKX2-1
2multiple endocrine neoplasia31.2RET, PRKAR1A
3goiter31.1BRAF, RET, NKX2-1
4nodular goiter31.1RET, BRAF
5parathyroid adenoma31.1RET, PRKAR1A
6thyroid adenoma30.9RET, PRKAR1A, BRAF
7primary hyperparathyroidism30.8PRKAR1A, RET
8thyroid carcinoma, follicular30.7BRAF, RET, NKX2-1
9adenoma30.4NKX2-1, NTRK1, RET, PRKAR1A, BRAF
10thyroid cancer30.1BRAF, RET, CCDC6, NTRK1, NKX2-1, NCOA4
11follicular adenoma30.1NKX2-1, NTRK1, RET, BRAF
12papillary carcinoma30.0BRAF, RET, NTRK1, NKX2-1, NCOA4
13hypothyroidism29.8BRAF, RET, FOXE1, NKX2-1
14thyroiditis10.7
15familial papillary thyroid carcinoma10.7
16endotheliitis10.7
17familial papillary or follicular thyroid carcinoma10.6
18hashimoto thyroiditis10.6
19multinodular goiter10.6
20laryngitis10.6
21pheochromocytoma10.5
22multicentric papillary thyroid carcinoma10.5
23graves' disease10.5
24thyroid carcinoma, papillary, with papillary renal neoplasia10.5
25paraganglioma10.5
26hyperparathyroidism10.5
27pituitary adenoma10.5
28retinoblastoma10.4
29choroiditis10.4
30cervicitis10.4
31lymphadenitis10.4
32teratoma10.4
33familial papillary thyroid carcinoma with renal papillary neoplasia10.4
34leiomyosarcoma10.4
35parathyroid carcinoma10.3
36ataxia-telangiectasia10.3
37adenomatous polyposis coli10.3
38cerebritis10.3
39laryngeal squamous cell carcinoma10.3
40warthin tumor10.3
41ataxia10.3
42hypoxia10.3
43dermatomyositis10.3
44hypoparathyroidism10.3RET, PRKAR1A
45cowden syndrome 210.2
46systemic lupus erythematosus10.2
47hepatocellular carcinoma10.2
48breast cancer10.2
49pendred syndrome10.2
50goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Papillary:



Diseases related to thyroid carcinoma, papillary

Symptoms for Thyroid Carcinoma, Papillary

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Symptoms by clinical synopsis from OMIM:

188550

Clinical features from OMIM:

188550

HPO human phenotypes related to Thyroid Carcinoma, Papillary:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 papillary thyroid carcinoma HP:0002895

Drugs & Therapeutics for Thyroid Carcinoma, Papillary

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Drug clinical trials:

Search ClinicalTrials for Thyroid Carcinoma, Papillary

Search NIH Clinical Center for Thyroid Carcinoma, Papillary

Genetic Tests for Thyroid Carcinoma, Papillary

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Genetic tests related to Thyroid Carcinoma, Papillary:

id Genetic test Affiliating Genes
1 Papillary Thyroid Carcinoma22

Anatomical Context for Thyroid Carcinoma, Papillary

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MalaCards organs/tissues related to Thyroid Carcinoma, Papillary:

31
Thyroid, Lymph node

Animal Models for Thyroid Carcinoma, Papillary or affiliated genes

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MGI Mouse Phenotypes related to Thyroid Carcinoma, Papillary:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5BRAF, PRKAR1A, RET, MINPP1, NTRK1, ERC1
2MP:00020068.4TRIM24, BRAF, PRKAR1A, RET, NKX2-1, TRIM33
3MP:00053798.0PRKAR1A, RET, FOXE1, NKX2-1, TRIM33, BRAF
4MP:00053817.9BRAF, PRKAR1A, RET, FOXE1, NKX2-1, TRIM33
5MP:00107686.8BRAF, PRKAR1A, RET, FOXE1, NTRK1, NKX2-1

Publications for Thyroid Carcinoma, Papillary

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Variations for Thyroid Carcinoma, Papillary

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Clinvar genetic disease variations for Thyroid Carcinoma, Papillary:

6
id Gene Variation Type Significance SNP ID Assembly Location
1BRAFNM_004333.4(BRAF): c.1799T> A (p.Val600Glu)single nucleotide variantPathogenicrs113488022GRCh37Chr 7, 140453136: 140453136
2NDUFA13NM_015965.6(NDUFA13): c.15G> C (p.Lys5Asn)single nucleotide variantPathogenicrs137852869GRCh37Chr 19, 19627062: 19627062
3MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
4MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Cosmic variations for Thyroid Carcinoma, Papillary:

7 (show all 98)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1778PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
21666844PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
329110PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
417446PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
529329PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
629106PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
7760PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
812597PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
927133PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1029108PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
11763PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1217443PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
13759PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
14775PIK3CAthyroid,NS,carcinoma,papillary carcinoma3
1526146KRASthyroid,NS,carcinoma,papillary carcinoma3
16528KRASthyroid,NS,carcinoma,papillary carcinoma3
17551KRASthyroid,NS,carcinoma,papillary carcinoma3
18529KRASthyroid,NS,carcinoma,papillary carcinoma3
19522KRASthyroid,NS,carcinoma,papillary carcinoma3
20548KRASthyroid,NS,carcinoma,papillary carcinoma3
21527KRASthyroid,NS,carcinoma,papillary carcinoma3
22520KRASthyroid,NS,carcinoma,papillary carcinoma3
23533KRASthyroid,NS,carcinoma,papillary carcinoma3
24521KRASthyroid,NS,carcinoma,papillary carcinoma3
25516KRASthyroid,NS,carcinoma,papillary carcinoma3
26549KRASthyroid,NS,carcinoma,papillary carcinoma3
27532KRASthyroid,NS,carcinoma,papillary carcinoma3
28517KRASthyroid,NS,carcinoma,papillary carcinoma3
29486HRASthyroid,NS,carcinoma,papillary carcinoma3
30503HRASthyroid,NS,carcinoma,papillary carcinoma3
31485HRASthyroid,NS,carcinoma,papillary carcinoma3
32488HRASthyroid,NS,carcinoma,papillary carcinoma3
33480HRASthyroid,NS,carcinoma,papillary carcinoma3
34490HRASthyroid,NS,carcinoma,papillary carcinoma3
35110720HRASthyroid,NS,carcinoma,papillary carcinoma3
36484HRASthyroid,NS,carcinoma,papillary carcinoma3
37483HRASthyroid,NS,carcinoma,papillary carcinoma3
38496HRASthyroid,NS,carcinoma,papillary carcinoma3
39499HRASthyroid,NS,carcinoma,papillary carcinoma3
40481HRASthyroid,NS,carcinoma,papillary carcinoma3
41482HRASthyroid,NS,carcinoma,papillary carcinoma3
42586NRASthyroid,NS,carcinoma,papillary carcinoma3
43564NRASthyroid,NS,carcinoma,papillary carcinoma3
44585NRASthyroid,NS,carcinoma,papillary carcinoma3
45573NRASthyroid,NS,carcinoma,papillary carcinoma3
46570NRASthyroid,NS,carcinoma,papillary carcinoma3
47562NRASthyroid,NS,carcinoma,papillary carcinoma3
48583NRASthyroid,NS,carcinoma,papillary carcinoma3
49584NRASthyroid,NS,carcinoma,papillary carcinoma3
50580NRASthyroid,NS,carcinoma,papillary carcinoma3
5128048NRASthyroid,NS,carcinoma,papillary carcinoma3
5210834TP53thyroid,NS,carcinoma,papillary carcinoma3
5343981TP53thyroid,NS,carcinoma,papillary carcinoma3
5443980TP53thyroid,NS,carcinoma,papillary carcinoma3
5510739TP53thyroid,NS,carcinoma,papillary carcinoma3
5643979TP53thyroid,NS,carcinoma,papillary carcinoma3
5710771TP53thyroid,NS,carcinoma,papillary carcinoma3
5810704TP53thyroid,NS,carcinoma,papillary carcinoma3
5910867TP53thyroid,NS,carcinoma,papillary carcinoma3
6010863TP53thyroid,NS,carcinoma,papillary carcinoma3
615759CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
625760CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
635662CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
645706CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
655762CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
665707CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
675761CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
685723CTNNB1thyroid,NS,carcinoma,papillary carcinoma3
6921549BRAFthyroid,NS,carcinoma,papillary carcinoma3
7030671BRAFthyroid,NS,carcinoma,papillary carcinoma3
711131BRAFthyroid,NS,carcinoma,papillary carcinoma3
7213982BRAFthyroid,NS,carcinoma,papillary carcinoma3
73476BRAFthyroid,NS,carcinoma,papillary carcinoma3
74478BRAFthyroid,NS,carcinoma,papillary carcinoma3
75475BRAFthyroid,NS,carcinoma,papillary carcinoma3
7614193SMAD4thyroid,NS,carcinoma,papillary carcinoma3
7714196SMAD4thyroid,NS,carcinoma,papillary carcinoma3
7814189SMAD4thyroid,NS,carcinoma,papillary carcinoma3
7914186SMAD4thyroid,NS,carcinoma,papillary carcinoma3
8014185SMAD4thyroid,NS,carcinoma,papillary carcinoma3
8120897EGFRthyroid,NS,carcinoma,papillary carcinoma3
8220896EGFRthyroid,NS,carcinoma,papillary carcinoma3
8313182EGFRthyroid,NS,carcinoma,papillary carcinoma3
846224EGFRthyroid,NS,carcinoma,papillary carcinoma3
8529274EGFRthyroid,NS,carcinoma,papillary carcinoma3
8696531IDH1thyroid,NS,carcinoma,papillary carcinoma3
8796534IDH1thyroid,NS,carcinoma,papillary carcinoma3
8897131IDH1thyroid,NS,carcinoma,papillary carcinoma3
8996923IDH1thyroid,NS,carcinoma,papillary carcinoma3
905034PTENthyroid,NS,carcinoma,papillary carcinoma3
915092PTENthyroid,NS,carcinoma,papillary carcinoma3
9227899GNASthyroid,NS,carcinoma,papillary carcinoma3
9327887GNASthyroid,NS,carcinoma,papillary carcinoma3
9433765AKT1thyroid,NS,carcinoma,papillary carcinoma3
9513292CDKN2Athyroid,NS,carcinoma,papillary carcinoma3
96707METthyroid,NS,carcinoma,papillary carcinoma3
9717721VHLthyroid,NS,carcinoma,papillary carcinoma3
98786FLT3thyroid,NS,carcinoma,papillary carcinoma3

Expression for genes affiliated with Thyroid Carcinoma, Papillary

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Search GEO for disease gene expression data for Thyroid Carcinoma, Papillary.

Pathways for genes affiliated with Thyroid Carcinoma, Papillary

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Pathways related to Thyroid Carcinoma, Papillary according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.7BRAF, PRKAR1A, NTRK1
2
Show member pathways
9.5TRIM24, NTRK1, PRKAR1A, BRAF
39.2TRIM24, TRIM33, PRKAR1A, BRAF, TPR
48.9PRKAR1A, RET, NTRK1, NKX2-1
58.1TFG, TPR, BRAF, RET, CCDC6, NTRK1
68.1NCOA4, TFG, TPR, BRAF, RET, CCDC6

Compounds for genes affiliated with Thyroid Carcinoma, Papillary

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 24HMDB
See all sources

Compounds related to Thyroid Carcinoma, Papillary according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1cipa4310.0NTRK1, RET
2regorafenib49 1210.7NTRK1, RET, BRAF
3sodium iodide439.5BRAF, RET, NKX2-1
4imatinib43 49 1211.2BRAF, RET, NTRK1
5steroid439.0PRKAR1A, NTRK1, NKX2-1, NCOA4, TRIM24
6iodide43 2410.0BRAF, FOXE1, NKX2-1
7paraffin438.9BRAF, RET, NTRK1, NKX2-1
8estrogen438.9TRIM24, NCOA4, NKX2-1, NTRK1, BRAF
9cyclic amp43 249.8BRAF, PRKAR1A, RET, NTRK1, NKX2-1
10retinoic acid43 249.6BRAF, RET, NTRK1, NKX2-1, NDUFA13, TRIM24
11sodium43 249.3NKX2-1, NTRK1, FOXE1, BRAF
12tyrosine436.7TRIM27, GOLGA5, TFG, TPR, BRAF, RET

GO Terms for genes affiliated with Thyroid Carcinoma, Papillary

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Cellular components related to Thyroid Carcinoma, Papillary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear membraneGO:00319659.3TRIM27, PCM1, TPR
2nucleoplasmGO:00056548.7TRIM27, TRIM33, NDUFA13, NKX2-1, TPR

Biological processes related to Thyroid Carcinoma, Papillary according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to epidermal growth factorGO:00708499.9BRAF, TPR
2regulation of protein stabilityGO:00316479.9TRIM24, TPR
3peptidyl-tyrosine phosphorylationGO:00181089.5TRIM27, NTRK1, RET
4thyroid gland developmentGO:00308788.9FOXE1, NKX2-1
5negative regulation of transcription, DNA-templatedGO:00458928.7TRIM24, TRIM33, NDUFA13, FOXE1
6positive regulation of transcription, DNA-templatedGO:00458938.4TRIM24, NCOA4, NKX2-1, FOXE1, RET
7negative regulation of transcription from RNA polymerase II promoterGO:00001228.2TPR, FOXE1, NKX2-1, TRIM33, TRIM27

Molecular functions related to Thyroid Carcinoma, Papillary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.5TRIM27, NTRK1, RET
2protein bindingGO:00055155.7TRIM24, TFG, TPR, BRAF, PRKAR1A, RET

Products for genes affiliated with Thyroid Carcinoma, Papillary

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Sources for Thyroid Carcinoma, Papillary

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet