MCID: THY009
MIFTS: 46

Thyroid Lymphoma

Categories: Immune diseases, Blood diseases, Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Lymphoma

Summaries for Thyroid Lymphoma

MalaCards based summary : Thyroid Lymphoma is related to hashimoto thyroiditis and lymphoma, and has symptoms including goiter, lymphoma and broad neck. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cellular Senescence (REACTOME). Affiliated tissues include thyroid, b cells and colon, and related phenotypes are hematopoietic system and embryo

Wikipedia : 72 Thyroid lymphoma is a rare malignant tumor constituting 1% to 2% of all thyroid malignancies and less... more...

Related Diseases for Thyroid Lymphoma

Diseases related to Thyroid Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 hashimoto thyroiditis 11.3
2 lymphoma 10.7
3 thyroiditis 10.7
4 splenic diffuse red pulp small b-cell lymphoma 10.3 CCNA2 TP53
5 brain stem astrocytic neoplasm 10.2 CDKN2A TP53
6 squamous cell carcinoma of the oropharynx 10.2 CDKN2A TP53
7 spitz nevus 10.2 CDKN2A TP53
8 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
9 squamous cell carcinoma of the larynx 10.2 CDKN2A TP53
10 bartholin's gland benign neoplasm 10.2 CDKN2A TP53
11 bladder carcinoma in situ 10.2 CDKN2A TP53
12 anal squamous cell carcinoma 10.2 CDKN2A TP53
13 vulva squamous cell carcinoma 10.2 CDKN2A TP53
14 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
15 bone squamous cell carcinoma 10.2 CDKN2A TP53
16 megaesophagus 10.2 CDKN2A TP53
17 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
18 oral leukoplakia 10.2 CDKN2A TP53
19 anogenital venereal wart 10.2 CDKN2A TP53
20 balanitis xerotica obliterans 10.2 CDKN2A TP53
21 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
22 small cell neuroendocrine carcinoma 10.2 CDKN2A TP53
23 meningeal melanomatosis 10.2 CDKN2A TP53
24 dedifferentiated liposarcoma 10.2 CDKN2A TP53
25 bladder squamous cell carcinoma 10.2 CDKN2A TP53
26 esophagus adenocarcinoma 10.2 CDKN2A TP53
27 oropharynx cancer 10.2 CDKN2A TP53
28 endocervical adenocarcinoma 10.2 CDKN2A TP53
29 small cell sarcoma 10.2 CDKN2A TP53
30 cervix small cell carcinoma 10.2 CDKN2A TP53
31 necrotizing sialometaplasia 10.2 CDKN2A TP53
32 basaloid squamous cell carcinoma 10.2 CDKN2A TP53
33 biliary tract neoplasm 10.2 CDKN2A TP53
34 inverted papilloma 10.2 CDKN2A TP53
35 optic nerve neoplasm 10.1 CDKN2A TP53
36 cellular schwannoma 10.1 CDKN2A TP53
37 tenosynovial giant cell tumor 10.1 CDKN2A CDKN2B
38 vulva cancer 10.1 CDKN2A TP53
39 pre-malignant neoplasm 10.1 CDKN2A TP53
40 atypical neurofibroma 10.1 CDKN2A CDKN2B
41 mucinous adenocarcinoma 10.1 CDKN2A TP53
42 juvenile pilocytic astrocytoma 10.1 CDKN2A TP53
43 barrett's adenocarcinoma 10.1 CDKN2A TP53
44 ewing's family of tumors 10.1 CDKN2A CDKN2B
45 gastrointestinal system benign neoplasm 10.1 CDKN2A TP53
46 pancreatic ductal carcinoma 10.1 CDKN2A TP53
47 actinic cheilitis 10.1 TNF TP53
48 penile cancer 10.1 CDKN2A TP53
49 in situ carcinoma 10.1 CDKN2A TP53
50 lichen sclerosus 10.1 TNF TP53

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

55 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 55 31 obligate (100%) Obligate (100%) HP:0000853
2 lymphoma 55 31 obligate (100%) Obligate (100%) HP:0002665
3 broad neck 55 31 hallmark (90%) Very frequent (99-80%) HP:0000475
4 hypothyroidism 55 31 frequent (33%) Frequent (79-30%) HP:0000821
5 hashimoto thyroiditis 55 31 frequent (33%) Frequent (79-30%) HP:0000872
6 hoarse voice 55 31 frequent (33%) Frequent (79-30%) HP:0001609
7 dysphagia 55 31 frequent (33%) Frequent (79-30%) HP:0002015
8 lymphadenopathy 55 31 frequent (33%) Frequent (79-30%) HP:0002716
9 upper airway obstruction 55 31 frequent (33%) Frequent (79-30%) HP:0002781
10 stridor 55 31 frequent (33%) Frequent (79-30%) HP:0010307
11 hyperthyroidism 55 31 occasional (7.5%) Occasional (29-5%) HP:0000836
12 pain 55 31 occasional (7.5%) Occasional (29-5%) HP:0012531
13 respiratory distress 55 31 very rare (1%) Very rare (<4-1%) HP:0002098
14 dyspnea 55 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 CCNA2 CDKN2A CDKN2B IL7 PICALM TNF
2 embryo MP:0005380 9.72 TP53 CCNA2 CDKN2A PICALM TNF
3 immune system MP:0005387 9.7 TP53 CCNA2 CDKN2A CDKN2B IL7 PICALM
4 integument MP:0010771 9.35 TP53 CDKN2A CDKN2B PICALM TNF
5 no phenotypic analysis MP:0003012 9.02 TP53 CDKN2A CDKN2B IL7 TNF

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

38
Thyroid, B Cells, Colon, T Cells

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 191)
# Title Authors Year
1
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial<sup>18</sup>F-FDG PET/CT Imaging. ( 29393054 )
2018
2
Primary thyroid lymphoma: A case report and review of the literature. ( 28053701 )
2017
3
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. ( 29058491 )
2017
4
Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017]. ( 29081471 )
2017
5
Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma. ( 28695809 )
2017
6
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. ( 29268549 )
2017
7
Eleven patients with primary thyroid lymphoma: a single center experience ( 29151299 )
2017
8
Primary thyroid lymphoma: a rare but challenging diagnosis. ( 28581452 )
2017
9
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. ( 28690277 )
2017
10
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26608372 )
2016
11
Primary thyroid lymphoma. ( 26985163 )
2016
12
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26614433 )
2016
13
Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report. ( 28031089 )
2016
14
Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco. ( 28191800 )
2016
15
Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature. ( 27126096 )
2016
16
Clinical Presentation and Diagnostic Challenges of Thyroid Lymphoma: A Cohort Study. ( 27256107 )
2016
17
Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases. ( 27086809 )
2016
18
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Primary Thyroid Lymphoma for Elderly Adults. ( 27557116 )
2016
19
Residual FDG uptake of primary thyroid lymphoma after treatment may overestimate residual lymphoma. ( 27614754 )
2016
20
Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration. ( 26411267 )
2015
21
Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma. ( 26687264 )
2015
22
12 cases of primary thyroid lymphoma in China. ( 25736543 )
2015
23
Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: A pilot study. ( 26960472 )
2015
24
Primary thyroid lymphoma: The two ends of the spectrum. ( 26416071 )
2015
25
Core needle biopsy could reduce diagnostic surgery in patients with anaplastic thyroid cancer or thyroid lymphoma. ( 26201291 )
2015
26
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
27
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study. ( 26665123 )
2015
28
Primary thyroid lymphoma: multi-slice computed tomography findings. ( 25735344 )
2015
29
Hypothyroidism after radiotherapy for primary thyroid lymphoma. ( 25075081 )
2014
30
Primary thyroid lymphoma: A rare disease. ( 25745292 )
2014
31
Primary thyroid lymphoma. ( 24935697 )
2014
32
Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases. ( 24696693 )
2014
33
Thyroid lymphoma on a background of Hashimoto's thyroiditis: PET/CT appearances. ( 24679651 )
2014
34
Primary thyroid lymphoma: case series with review of literature. ( 25332615 )
2014
35
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients. ( 24547778 )
2014
36
Aggressive primary thyroid lymphoma: imaging features of two elderly patients. ( 25060184 )
2014
37
Sonographic appearance of primary thyroid lymphoma-preliminary experience. ( 25474402 )
2014
38
Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis. ( 24864614 )
2014
39
Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. ( 24642841 )
2014
40
Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature. ( 25364417 )
2014
41
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. ( 24005594 )
2013
42
Primary thyroid lymphoma: a clinical review. ( 23714679 )
2013
43
Is 18F-FDG PET/CT useful for distinguishing between primary thyroid lymphoma and chronic thyroiditis? ( 23816945 )
2013
44
Clinicopathologic study and outcome analysis of thyroid lymphomas: experience from a tertiary cancer center. ( 22368156 )
2013
45
Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET/CT. ( 23856826 )
2013
46
Tracheal invasion and perforation from advanced primary thyroid lymphoma: a case report and literature review. ( 23702317 )
2013
47
Thyroid lymphoma: recent advances in diagnosis and optimal management strategies. ( 23881987 )
2013
48
Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study. ( 24501704 )
2013
49
Thyroid lymphoma: diagnostic pitfalls on pre-operative ago-biopsy. ( 23134840 )
2013
50
Primary thyroid lymphoma: a series of two cases and review of literature. ( 24772759 )
2013

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 CCNA2 CCNB1 CDKN2A CDKN2B TP53
2
Show member pathways
12.91 CCNA2 CDKN2A CDKN2B TP53
3
Show member pathways
12.72 CCNA2 IL7 TNF TP53
4
Show member pathways
12.71 CCNA2 CCNB1 CDKN2A TP53
5 12.57 CDKN2A CDKN2B IL7 TP53
6 12.25 CCNA2 CCNB1 CDKN2A TP53
7
Show member pathways
12.24 CCNA2 CCNB1 CDKN2A CDKN2B TP53
8
Show member pathways
12.23 CCNA2 CCNB1 TP53
9 12.16 CDKN2A CDKN2B TNF TP53
10
Show member pathways
12.15 CCNB1 CDKN2A TP53
11 12.04 CCNA2 CDKN2A CDKN2B TP53
12 12.01 CCNA2 CCNB1 CDKN2A CDKN2B TP53
13
Show member pathways
11.99 CCNA2 CDKN2A CDKN2B
14
Show member pathways
11.9 CCNA2 CCNB1 CDKN2A CDKN2B TP53
15 11.83 CCNB1 CDKN2A TP53
16
Show member pathways
11.71 CCNA2 CCNB1 TP53
17 11.63 CCNA2 CCNB1 TP53
18
Show member pathways
11.53 CCNA2 CDKN2A TP53
19 11.32 CDKN2B TP53
20
Show member pathways
11.3 CCNB1 TP53
21 11.29 CCNA2 TP53
22 11.29 TNF TP53
23 11.23 CCNA2 CCNB1 CDKN2A CDKN2B TP53
24
Show member pathways
11.18 CCNA2 CCNB1
25 11.15 CCNA2 CCNB1
26 11.13 IL7 TNF
27 11.09 IL7 TNF
28 11.09 CCNA2 CCNB1 TP53
29 11.05 CDKN2A CDKN2B TP53
30 10.96 CCNA2 CDKN2A TNF TP53
31 10.93 CDKN2A TP53
32
Show member pathways
10.92 CDKN2A TP53
33 10.84 CCNB1 TP53

GO Terms for Thyroid Lymphoma

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.69 CCNB1 PICALM TNF
2 cell cycle arrest GO:0007050 9.63 CDKN2A CDKN2B TP53
3 G2/M transition of mitotic cell cycle GO:0000086 9.61 CCNA2 CCNB1 CDKN2B
4 protein complex assembly GO:0006461 9.58 CCNB1 PICALM TP53
5 positive regulation of fibroblast proliferation GO:0048146 9.55 CCNA2 CCNB1
6 positive regulation of cell cycle GO:0045787 9.54 CCNB1 TP53
7 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.52 IL7 TNF
8 cellular response to hypoxia GO:0071456 9.5 CCNA2 CCNB1 TP53
9 negative regulation of phosphorylation GO:0042326 9.49 CDKN2A CDKN2B
10 positive regulation of chemokine production GO:0032722 9.48 IL7 TNF
11 cellular response to organic cyclic compound GO:0071407 9.43 CCNA2 CCNB1 TNF
12 replicative senescence GO:0090399 9.37 CDKN2A TP53
13 cell cycle GO:0007049 9.35 CCNA2 CCNB1 CDKN2A CDKN2B TP53
14 Ras protein signal transduction GO:0007265 9.33 CCNA2 CDKN2A TP53
15 positive regulation of transcription, DNA-templated GO:0045893 9.02 CCNA2 CDKN2A PICALM TNF TP53

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 CDKN2A TP53
2 protein kinase binding GO:0019901 9.02 CCNA2 CCNB1 CDKN2A CDKN2B TP53
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN2B

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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