MCID: THY032
MIFTS: 56

Thyroiditis malady

Endocrine diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Thyroiditis

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Aliases & Descriptions for Thyroiditis:

Name: Thyroiditis 8 10 44 61


Classifications:



External Ids:

Disease Ontology8 DOID:7166
ICD9CM27 245.8
ICD1025 E06, E06.9

Summaries for Thyroiditis

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Wikipedia:64 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards based summary: Thyroiditis is related to autoimmune thyroiditis and thyroid cancer. An important gene associated with Thyroiditis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The compounds iodotyrosine and sodium iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are respiratory system and tumorigenesis.

Related Diseases for Thyroiditis

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Diseases in the Thyroiditis family:

Autoimmune Thyroiditis Subacute Thyroiditis
Acute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1100)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune thyroiditis32.2TG, CALCA, TPO
2thyroid cancer32.2TG, TSHR, TPO, CALCA
3subacute thyroiditis32.0TSHR, TG, TPO
4hypothyroidism31.9TSHR, TG, TPO
5papillary carcinoma31.7TG, TSHR, TPO, CALCA
6multiple endocrine neoplasia31.5CALCA, TG
7endemic goiter31.4TSHR, TG, TPO
8struma ovarii31.4TSHR, TG
9adenoma31.4TPO, CTLA4, CALCA, TSHB, TSHR, TG
10myxedema31.3TG, TSHR, TPO
11thyroid hormone resistance31.3SERPINA7, TG
12follicular adenoma31.2TSHR, TPO, TG, CALCA
13multinodular goiter31.2TPO, TSHR, CALCA, TG
14pendred syndrome31.2TG, TPO
15mucoepidermoid carcinoma31.1CALCA, TG
16thyroid carcinoma, papillary31.1TPO, TG, TSHR
17thyroid adenoma31.1TSHR, SERPINA7, TG, TPO
18thyrotoxicosis31.1TPO, SERPINA7, TSHR, TG
19thyroid carcinoma, follicular31.1TSHR, CALCA, TG
20hepatitis c31.1CTLA4, TSHR, IFNG
21celiac disease31.0TPO, CTLA4, TG
22goiter31.0CALCA, TSHB, TSHR, SERPINA7, TPO, TG
23alopecia30.9AIRE
24hypoparathyroidism30.9CTLA4, CALCA, AIRE
25hyperthyroidism30.9TPO, TG, TSHR, SERPINA7, TSHB, CTLA4
26congenital hypothyroidism30.9TSHB, TPO, TG, TSHR, SERPINA7
27hepatitis30.8FASLG, AIRE, SERPINA7, CTLA4
28pernicious anemia30.8TPO, TG
29nodular goiter30.8CTLA4, CALCA, ICAM1, TSHR, TG, TPO
30nontoxic goiter30.7FASLG, TPO, TSHR, TG
31plummer's disease30.7ICAM1, TG, TPO
32autoimmune hepatitis30.6TPO, AIRE, CTLA4
33down syndrome30.6TSHR, TPO, AIRE
34hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia30.6TG, TSHR, SERPINA7
35hyperthyroxinemia30.6TPO, SERPINA7, TSHR
36dermatitis30.5CTLA4, IFNG, ICAM1
37connective tissue disease30.5CTLA4, IL2RA, ICAM1
38arthritis30.5CTLA4, IFNG, CALCA, ICAM1
39thyroid cancer, anaplastic30.5TPO, TG, TSHR, CALCA
40addison's disease30.5TPO, CTLA4, TG, AIRE
41myasthenia gravis30.4IFNG, CTLA4, AIRE
42hepatitis b30.4CTLA4, IFNG, IL2RA
43turner syndrome30.4TPO, TG, SERPINA7
44goiter, multinodular 1, with or without sertoli-leydig cell tumors30.4TPO, TG
45alopecia areata30.3AIRE, ICAM1, IFNG
46sjogren's syndrome30.2IL2RA, ICAM1, TSHR, FASLG
47psoriasis30.2IFNG, ICAM1, IL2RA, CTLA4
48melanoma30.2FASLG, ICAM1, IFNG, CTLA4, TSHR
49leukemia30.2TSHR, IL2RA, ICAM1, FASLG, IFNG
50toxic diffuse goiter30.2TG, TPO, TSHR

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Symptoms for Thyroiditis

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Drugs & Therapeutics for Thyroiditis

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Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Genetic Tests for Thyroiditis

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Anatomical Context for Thyroiditis

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MalaCards organs/tissues related to Thyroiditis:

31
Thyroid, Lymph node, Pituitary, Eye, Lung, Testes, T cells, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Thymus, Heart, Kidney, Ovary, Colon, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Skeletal muscle, Salivary gland, Monocytes, Testis, Neutrophil, Spinal cord, Placenta, Fetal thyroid, Prostate, Trachea, Smooth muscle, Cortex, Retina, Adrenal gland, Cervix, Myeloid, Fetal brain, Tongue, Whole blood, Spleen, Cerebellum, Temporal lobe, Cardiac myocytes, Nk cells, Tonsil, Atrioventricular node, Fetal lung, Appendix

Animal Models for Thyroiditis or affiliated genes

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Publications for Thyroiditis

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Articles related to Thyroiditis:

(show top 50)    (show all 13737)
idTitleAuthorsYear
1
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (25754017)
2015
2
Cytomorphology of columnar cell variant of papillary carcinoma thyroid: A case report and review of the literature. (25379049)
2014
3
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
4
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
5
Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients. (23865082)
2013
6
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
7
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
8
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
9
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
10
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
11
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
12
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
13
Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis. (24154902)
2013
14
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
15
Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis. (20738834)
2011
16
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
17
Molecular characterization, gene expression and transcriptional regulation of thyroid hormone receptors in Senegalese sole. (19028494)
2009
18
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
19
Analysis of intracellular proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders]. (17880809)
2007
20
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function. (17458906)
2007
21
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
22
Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae). (16426605)
2006
23
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
24
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. (15727947)
2005
25
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
26
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
27
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene. (15476441)
2004
28
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
29
Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. (11463576)
2001
30
Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (10069663)
1999
31
Protein-protein interaction domains and the heterodimerization of thyroid hormone receptor variant alpha2 with retinoid X receptors. (9773977)
1998
32
Neoexpression of the epithelial adhesion complex antigens in thyroid tumours is associated with proliferation and squamous differentiation markers. (9602711)
1998
33
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissue. (9360536)
1997
34
Differential effects of 2'-deoxyguanosine on peripheral blood mononuclear cell proliferation in healthy donors and Hashimoto's thyroiditis patients. (8980658)
1996
35
Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements. (7775449)
1995
36
The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. (7731681)
1995
37
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
38
Multidrug resistance gene and P-glycoprotein expression in anaplastic carcinoma of the thyroid. (7812988)
1994
39
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
40
Study of the localization and the concentration of superoxide dismutase in various thyroid disorders]. (8232185)
1993
41
Homology model of thyroxine binding globulin and elucidation of the thyroid hormone binding site. (1631046)
1992
42
Monoclonal gammopathy as a clue to the presence of thyroid lymphoma associated with auto-immune thyroiditis. (1445050)
1992
43
Medullary cancer of the thyroid and multiple endocrine neoplastic syndromes]. (1351314)
1992
44
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin. (1679761)
1991
45
Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase. (1706451)
1991
46
Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (1850510)
1991
47
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. (2153155)
1990
48
Hashimoto's thyroiditis as a risk factor of thyroid lymphoma. (2220394)
1990
49
THYROID CRISIS. (14167406)
1964
50
Thyroid crisis. (14829802)
1951

Variations for Thyroiditis

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Expression for genes affiliated with Thyroiditis

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Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

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Pathways related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.6TPO, TG, TSHR
39.6TSHB, TSHR, CALCA
49.5ICAM1, IFNG
59.5IFNG, IL2RA
69.5IFNG, IL2RA
79.5IL2RA, IFNG
8
Show member pathways
9.3TSHB, TPO, TSHR, TG
99.2FASLG, IFNG, CALCA
109.2CTLA4, ICAM1, HLA-DRB4
11
Show member pathways
Type III interferon signaling36
9.2TPO, IFNG, IL2RA
129.2IFNG, ICAM1, FASLG
139.2ICAM1, FASLG, IFNG
14
Show member pathways
Immune response CD16 signaling in NK cells59
9.2ICAM1, IFNG, FASLG
15
Show member pathways
9.2CTLA4, IL2RA, HLA-DRB4
16
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.1IL2RA, FASLG, IFNG
17
Show member pathways
9.1IL2RA, IFNG, FASLG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.1FASLG, IFNG, IL2RA
199.1TPO, HLA-DRB4, IL2RA
209.0IL2RA, ICAM1, HLA-DRB4
218.9ICAM1, IFNG, HLA-DRB4
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.9IL2RA, CTLA4, IFNG, FASLG
23
Show member pathways
8.8FASLG, IFNG, TPO, IL2RA
248.7IFNG, CTLA4, HLA-DRB4, ICAM1
25
Show member pathways
8.7HLA-DRB4, AIRE, ICAM1, CTLA4
26
Show member pathways
8.5ICAM1, IL2RA, HLA-DRB4, IFNG
27
Show member pathways
8.1HLA-DRB4, IFNG, FASLG, IL2RA, ICAM1
28
Show member pathways
6.7IL2RA, IFNG, ICAM1, TSHB, TSHR, FASLG

Compounds for genes affiliated with Thyroiditis

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Compounds related to Thyroiditis according to GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.1TPO, TG
2sodium iodide4410.0TG, TSHR, TPO
3propylthiouracil44 1 1111.9TG, TPO, TSHR
4diiodotyrosine449.9TG, TPO
5chromium449.8FASLG, TG, TPO
6carbimazole44 1110.8IL2RA, TSHR, TPO
7con a449.5IL2RA, IFNG, CTLA4
8natalizumab44 1110.4IL2RA, IFNG, ICAM1
9nitrate449.4TPO, FASLG, IL2RA
10parthenolide44 110.4IFNG, ICAM1, FASLG
11amiodarone44 50 28 1112.4TG, SERPINA7, TPO
12okt3449.3IFNG, ICAM1, IL2RA
13hydrocortisone44 1 60 1112.3TG, TPO, IFNG, CALCA
14mycophenolate mofetil44 50 1111.3CTLA4, IL2RA, IFNG
15thalidomide44 50 60 1112.2IFNG, IL2RA, FASLG, CTLA4
16ivig449.2FASLG, TG, IFNG, IL2RA
17prednisolone44 28 1111.2IFNG, TG, IL2RA, TSHR
18acetylcholine44 50 28 24 1113.2TG, TPO, CTLA4, IL2RA, CALCA
19125i449.2TSHR, TG, TPO, SERPINA7
20iodide44 2410.2TSHR, TG, TPO, SERPINA7
21tacrolimus44 50 1111.0IFNG, FASLG, IL2RA, CTLA4
22ascorbic acid44 2410.0TPO, FASLG, TG, ICAM1, IL2RA
23guanine44 24 1111.0TG, ICAM1, CALCA, TSHR
24calcitriol44 60 24 1112.0CALCA, IL2RA, IFNG, TG
25ionomycin449.0CTLA4, IL2RA, IFNG, FASLG, TSHR
26iodine44 2410.0CTLA4, TSHR, SERPINA7, TG, TPO
27agarose449.0SERPINA7, FASLG, TPO, TSHR
28triiodothyronine448.9TSHB, TSHR, TG, TPO, SERPINA7
29rantes448.9CTLA4, FASLG, ICAM1, IL2RA, IFNG
30ribonucleic acid448.9TSHB, TPO, TSHR, SERPINA7, TG
31acth448.8TSHB, CALCA, TSHR, SERPINA7, TPO
32adenylate448.8FASLG, TSHR, IL2RA, CALCA, TG, TPO
33polysaccharide448.8TSHR, ICAM1, FASLG, TG, TPO, IL2RA
34pge2448.6IL2RA, ICAM1, CALCA, IFNG, FASLG
35thyroxine44 249.6TSHB, TSHR, SERPINA7, TG, CALCA, TPO
36glutamate448.6FASLG, TG, TSHR, TPO, IL2RA, CALCA
37genistein44 28 60 1 24 1113.6IL2RA, TPO, TG, FASLG, ICAM1, IFNG
38thymidine44 249.5TSHB, TSHR, CTLA4, IL2RA, TG, FASLG
39creatinine448.4IL2RA, CALCA, SERPINA7, TPO, TG
40retinoic acid44 249.4TSHR, IFNG, TG, ICAM1, TSHB, TPO
41cysteine448.4CTLA4, FASLG, TPO, TG, TSHR, IFNG
42methimazole44 1 1110.3TPO, TG, SERPINA7, TSHR, IL2RA, ICAM1
43aspartate448.3IL2RA, TSHR, FASLG, SERPINA7, TG, TPO
44cyclosporin a44 28 6010.3CTLA4, IFNG, ICAM1, FASLG, CALCA, TG
45cycloheximide448.3TG, FASLG, IFNG, ICAM1, TPO
46testosterone44 60 24 1111.2TPO, SERPINA7, FASLG, CALCA, IL2RA, TG
47vegf448.2FASLG, TSHR, ICAM1, IFNG, IL2RA, CALCA
48arginine448.1IL2RA, TSHR, SERPINA7, TG, TPO, IFNG
49estrogen447.8CALCA, CTLA4, TSHR, IL2RA, TSHB, FASLG
50tyrosine447.2TG, TPO, AIRE, SERPINA7, TSHR, FASLG

GO Terms for genes affiliated with Thyroiditis

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Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.9HLA-DRB4, TPO, FASLG, TSHR, ICAM1, CTLA4
2extracellular regionGO:00055767.9CALCA, IFNG, TSHB, FASLG, SERPINA7, TG
3external side of plasma membraneGO:00098977.9CTLA4, IL2RA, IFNG, ICAM1, FASLG, HLA-DRB4
4extracellular spaceGO:00056157.3TPO, TG, SERPINA7, FASLG, ICAM1, IFNG

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1TPO, TG
2thyroid hormone generationGO:000659010.0TG, TPO
3negative regulation of immune responseGO:005077710.0IL2RA, CTLA4
4leukocyte cell-cell adhesionGO:00071599.7ICAM1, CALCA
5extrinsic apoptotic signaling pathwayGO:00971919.6IFNG, FASLG
6inflammatory response to antigenic stimulusGO:00024379.5IL2RA, HLA-DRB4
7response to vitamin AGO:00331899.5TSHB, SERPINA7
8positive regulation of nitric oxide biosynthetic processGO:00454299.4IFNG, ICAM1
9cell-cell signalingGO:00072679.4FASLG, TSHR, TSHB, CALCA
10negative regulation of T cell proliferationGO:00421309.4HLA-DRB4, IL2RA, CTLA4
11interferon-gamma-mediated signaling pathwayGO:00603339.1IFNG, ICAM1, HLA-DRB4
12cytokine-mediated signaling pathwayGO:00192218.6IFNG, ICAM1, HLA-DRB4
13immune responseGO:00069558.5CTLA4, IL2RA, FASLG, HLA-DRB4, AIRE

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6CALCA, TSHB, TG

Sources for Thyroiditis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet