MCID: THY032
MIFTS: 66

Thyroiditis malady

Endocrine diseases, Rare diseases, Immune diseases categories
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Summaries for Thyroiditis

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Wikipedia:65 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards based summary: Thyroiditis is related to papillary thyroid carcinoma and autoimmune thyroiditis. An important gene associated with Thyroiditis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The compounds iodotyrosine and sodium iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Thyroiditis

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Thyroiditis, Aliases & Descriptions:

Name: Thyroiditis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:7166
ICD9CM27 245.8
ICD1025 E06, E06.9

Related Diseases for Thyroiditis

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Diseases in the Autoimmune Thyroiditis family:

Subacute Thyroiditis Acute Thyroiditis
thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1184)
idRelated DiseaseScoreTop Affiliating Genes
1papillary thyroid carcinoma32.3TPO, TG, TSHR
2autoimmune thyroiditis32.2TG, CALCA, TPO
3subacute thyroiditis32.0TSHR, TG, TPO
4hypothyroidism31.9TSHR, TG, TPO
5follicular thyroid carcinoma31.8TSHR, CALCA, TG
6papillary carcinoma31.7TG, TSHR, TPO, CALCA
7multiple endocrine neoplasia31.4CALCA, TG
8endemic goiter31.4TSHR, TG, TPO
9struma ovarii31.4TSHR, TG
10adenoma31.4TPO, CTLA4, CALCA, TSHB, TSHR, TG
11myxedema31.4TG, TSHR, TPO
12follicular adenoma31.2TSHR, TPO, TG, CALCA
13multinodular goiter31.2TPO, TSHR, CALCA, TG
14pendred syndrome31.1TG, TPO
15thyroid adenoma31.1TSHR, SERPINA7, TG, TPO
16mucoepidermoid carcinoma31.1CALCA, TG
17hepatitis c31.1CTLA4, TSHR, IFNG
18thyrotoxicosis31.1TPO, SERPINA7, TSHR, TG
19celiac disease31.0TPO, CTLA4, TG
20thyroid hormone resistance syndrome31.0SERPINA7, TG
21goiter31.0CALCA, TSHB, TSHR, SERPINA7, TPO, TG
22diabetes mellitus30.9AIRE, ICAM1, CALCA, CTLA4
23vitiligo30.9TPO, CTLA4, AIRE
24alopecia30.9AIRE
25hyperthyroidism30.9TPO, TG, TSHR, SERPINA7, TSHB, CTLA4
26hypoparathyroidism30.9CTLA4, CALCA, AIRE
27congenital hypothyroidism30.8TSHB, TPO, TG, TSHR, SERPINA7
28hepatitis30.8FASLG, AIRE, SERPINA7, CTLA4
29thyroid hurthle cell carcinoma30.8TG, TSHR, TPO, CALCA
30type 1 diabetes mellitus30.8IFNG, FASLG, TPO, CTLA4
31pernicious anemia30.8TPO, TG
32nontoxic goiter30.7FASLG, TPO, TSHR, TG
33nodular goiter30.7CTLA4, CALCA, ICAM1, TSHR, TG, TPO
34plummer's disease30.7ICAM1, TG, TPO
35thyroid agenesis30.7TG, TSHR, SERPINA7
36down syndrome30.6TSHR, TPO, AIRE
37autoimmune hepatitis30.6TPO, AIRE, CTLA4
38hyperthyroxinemia30.6TPO, SERPINA7, TSHR
39thyroid cancer, anaplastic30.6TPO, TG, TSHR, CALCA
40dermatitis30.5CTLA4, IFNG, ICAM1
41connective tissue disease30.5CTLA4, IL2RA, ICAM1
42arthritis30.5CTLA4, IFNG, CALCA, ICAM1
43addison's disease30.5TPO, CTLA4, TG, AIRE
44myasthenia gravis30.4IFNG, CTLA4, AIRE
45sarcoidosis30.4IL2RA, ICAM1, IFNG
46hepatitis b30.4CTLA4, IFNG, IL2RA
47pregnancy loss30.4TPO, TG
48turner syndrome30.3TPO, TG, SERPINA7
49alopecia areata30.2AIRE, ICAM1, IFNG
50melanoma30.2FASLG, ICAM1, IFNG, CTLA4, TSHR

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Symptoms for Thyroiditis

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Drugs & Therapeutics for Thyroiditis

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Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Genetic Tests for Thyroiditis

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Anatomical Context for Thyroiditis

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MalaCards organs/tissues related to Thyroiditis:

32
Thyroid, Lymph node, Pituitary, Eye, Lung, T cells, Testes, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Kidney, Heart, Ovary, Thymus, Colon, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Salivary gland, Monocytes, Skeletal muscle, Testis, Spinal cord, Placenta, Neutrophil, Fetal thyroid, Prostate, Smooth muscle, Trachea, Cortex, Retina, Adrenal gland, Cervix, Myeloid, Fetal brain, Tongue, Whole blood, Spleen, Cerebellum, Temporal lobe, Cardiac myocytes, Nk cells, Tonsil, Atrioventricular node, Fetal lung, Appendix

Animal Models for Thyroiditis or affiliated genes

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MGI Mouse Phenotypes related to Thyroiditis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4AIRE, FASLG, IFNG, CALCA, CTLA4
2MP:00020068.4AIRE, FASLG, ICAM1, IFNG, CALCA
3MP:00053918.3IFNG, ICAM1, FASLG, TPO, AIRE
4MP:00053818.1AIRE, FASLG, ICAM1, IFNG, IL2RA, CTLA4
5MP:00053797.7CTLA4, AIRE, TPO, TG, FASLG, TSHR
6MP:00036317.7AIRE, TG, FASLG, TSHR, ICAM1, IFNG
7MP:00053877.5AIRE, TPO, FASLG, TSHR, ICAM1, IFNG
8MP:00053787.4AIRE, TPO, TG, TSHR, ICAM1, IFNG
9MP:00053767.4AIRE, TPO, TG, FASLG, TSHR, ICAM1
10MP:00053977.3AIRE, TPO, TG, FASLG, TSHR, ICAM1
11MP:00107687.1AIRE, TPO, FASLG, TSHR, ICAM1, IFNG

Publications for Thyroiditis

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Articles related to Thyroiditis:

(show top 50)    (show all 13548)
idTitleAuthorsYear
1
Cytomorphology of columnar cell variant of papillary carcinoma thyroid: A case report and review of the literature. (25379049)
2014
2
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
3
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
4
Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients. (23865082)
2013
5
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
6
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
7
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
8
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
9
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
10
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
11
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
12
Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis. (24154902)
2013
13
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
14
Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis. (20738834)
2011
15
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
16
Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma. (19088163)
2009
17
Molecular characterization, gene expression and transcriptional regulation of thyroid hormone receptors in Senegalese sole. (19028494)
2009
18
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
19
Analysis of intracellular proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders]. (17880809)
2007
20
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function. (17458906)
2007
21
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
22
Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae). (16426605)
2006
23
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
24
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. (15727947)
2005
25
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
26
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
27
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene. (15476441)
2004
28
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
29
Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. (11463576)
2001
30
Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (10069663)
1999
31
Protein-protein interaction domains and the heterodimerization of thyroid hormone receptor variant alpha2 with retinoid X receptors. (9773977)
1998
32
Neoexpression of the epithelial adhesion complex antigens in thyroid tumours is associated with proliferation and squamous differentiation markers. (9602711)
1998
33
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissue. (9360536)
1997
34
Differential effects of 2'-deoxyguanosine on peripheral blood mononuclear cell proliferation in healthy donors and Hashimoto's thyroiditis patients. (8980658)
1996
35
Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements. (7775449)
1995
36
The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. (7731681)
1995
37
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
38
Multidrug resistance gene and P-glycoprotein expression in anaplastic carcinoma of the thyroid. (7812988)
1994
39
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
40
Study of the localization and the concentration of superoxide dismutase in various thyroid disorders]. (8232185)
1993
41
Homology model of thyroxine binding globulin and elucidation of the thyroid hormone binding site. (1631046)
1992
42
Monoclonal gammopathy as a clue to the presence of thyroid lymphoma associated with auto-immune thyroiditis. (1445050)
1992
43
Medullary cancer of the thyroid and multiple endocrine neoplastic syndromes]. (1351314)
1992
44
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin. (1679761)
1991
45
Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase. (1706451)
1991
46
Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (1850510)
1991
47
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. (2153155)
1990
48
Hashimoto's thyroiditis as a risk factor of thyroid lymphoma. (2220394)
1990
49
THYROID CRISIS. (14167406)
1964
50
Thyroid crisis. (14829802)
1951

Variations for Thyroiditis

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Expression for genes affiliated with Thyroiditis

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Expression patterns in normal tissues for genes affiliated with Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

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Pathways related to Thyroiditis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.6TPO, TG, TSHR
39.6CALCA, TSHB, TSHR
49.5IFNG, ICAM1
59.5IFNG, IL2RA
69.5IFNG, IL2RA
79.5IL2RA, IFNG
8
Show member pathways
9.3TPO, TG, TSHR, TSHB
99.2CALCA, IFNG, FASLG
109.2HLA-DRB4, ICAM1, CTLA4
11
Show member pathways
Type III interferon signaling37
9.2IL2RA, IFNG, TPO
129.2IFNG, ICAM1, FASLG
13
Show member pathways
Immune response CD16 signaling in NK cells60
9.2IFNG, ICAM1, FASLG
149.2FASLG, ICAM1, IFNG
15
Show member pathways
9.2HLA-DRB4, IL2RA, CTLA4
16
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1IL2RA, IFNG, FASLG
17
Show member pathways
9.1IL2RA, IFNG, FASLG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.1FASLG, IFNG, IL2RA
199.1HLA-DRB4, TPO, IL2RA
209.0IL2RA, ICAM1, HLA-DRB4
218.9HLA-DRB4, ICAM1, IFNG
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.9CTLA4, IL2RA, IFNG, FASLG
23
Show member pathways
8.8IL2RA, IFNG, FASLG, TPO
248.7HLA-DRB4, ICAM1, IFNG, CTLA4
25
Show member pathways
8.7AIRE, HLA-DRB4, ICAM1, CTLA4
26
Show member pathways
8.5HLA-DRB4, ICAM1, IFNG, IL2RA
27
Show member pathways
8.1HLA-DRB4, FASLG, ICAM1, IFNG, IL2RA
28
Show member pathways
6.7CTLA4, HLA-DRB4, TPO, TG, FASLG, TSHR

Compounds for genes affiliated with Thyroiditis

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Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.1TG, TPO
2sodium iodide4410.0TPO, TG, TSHR
3propylthiouracil44 2 1111.9TG, TSHR, TPO
4diiodotyrosine449.9TPO, TG
5chromium449.8TG, FASLG, TPO
6carbimazole44 1110.8IL2RA, TSHR, TPO
7con a449.5IFNG, IL2RA, CTLA4
8natalizumab44 1110.4IFNG, IL2RA, ICAM1
9nitrate449.4TPO, FASLG, IL2RA
10parthenolide44 210.4ICAM1, IFNG, FASLG
11amiodarone44 50 28 1112.4SERPINA7, TG, TPO
12okt3449.3IL2RA, ICAM1, IFNG
13hydrocortisone44 2 61 1112.3CALCA, IFNG, TG, TPO
14il 10449.3CTLA4, IL2RA, IFNG
15thalidomide44 50 61 1112.2CTLA4, IL2RA, FASLG, IFNG
16ivig449.2TG, FASLG, IFNG, IL2RA
17prednisolone44 28 1111.2TG, TSHR, IL2RA, IFNG
18acetylcholine44 50 28 24 1113.2CTLA4, TPO, CALCA, IL2RA, TG
19125i449.2TSHR, TG, TPO, SERPINA7
20iodide44 2410.2TSHR, TG, TPO, SERPINA7
21tacrolimus44 50 1111.0IL2RA, IFNG, CTLA4, FASLG
22ascorbic acid44 2410.0TPO, IL2RA, ICAM1, FASLG, TG
23guanine44 24 1111.0TG, ICAM1, TSHR, CALCA
24calcitriol44 61 24 1112.0CALCA, IL2RA, IFNG, TG
25ionomycin449.0CTLA4, IL2RA, IFNG, FASLG, TSHR
26iodine44 2410.0CTLA4, TSHR, SERPINA7, TG, TPO
27agarose449.0TPO, SERPINA7, FASLG, TSHR
28triiodothyronine448.9TSHB, TSHR, TG, TPO, SERPINA7
29rantes448.9IFNG, CTLA4, ICAM1, FASLG, IL2RA
30ribonucleic acid448.9TPO, TSHB, TSHR, SERPINA7, TG
31acth448.8CALCA, TSHR, SERPINA7, TPO, TSHB
32adenylate448.8TSHR, FASLG, IL2RA, TPO, TG, CALCA
33polysaccharide448.8TSHR, ICAM1, FASLG, TG, TPO, IL2RA
34pge2448.6IFNG, ICAM1, FASLG, IL2RA, CALCA
35thyroxine44 249.6TSHB, TSHR, SERPINA7, TG, CALCA, TPO
36glutamate448.6FASLG, TPO, CTLA4, CALCA, IL2RA, TSHR
37genistein44 28 61 2 24 1113.6IL2RA, TPO, TG, FASLG, ICAM1, IFNG
38thymidine44 249.5TSHB, TSHR, CTLA4, IL2RA, TG, FASLG
39creatinine448.4CALCA, IL2RA, TG, TPO, SERPINA7
40retinoic acid44 249.4IFNG, TSHR, ICAM1, TPO, TSHB, TG
41cysteine448.4CTLA4, IL2RA, IFNG, TSHR, TG, FASLG
42methimazole44 2 1110.3TPO, TG, SERPINA7, TSHR, IL2RA, ICAM1
43aspartate448.3TG, TPO, SERPINA7, FASLG, TSHR, IL2RA
44cyclosporin a44 28 6110.3CTLA4, IFNG, ICAM1, FASLG, CALCA, TG
45cycloheximide448.3ICAM1, FASLG, IFNG, TG, TPO
46testosterone44 61 24 1111.2CALCA, IL2RA, SERPINA7, TG, TPO, FASLG
47vegf448.2FASLG, TSHR, ICAM1, IFNG, IL2RA, CALCA
48arginine448.1IL2RA, IFNG, TSHR, SERPINA7, TG, TPO
49estrogen447.8CALCA, CTLA4, TSHR, IL2RA, TSHB, FASLG
50tyrosine447.2TG, TPO, AIRE, SERPINA7, TSHR, FASLG

GO Terms for genes affiliated with Thyroiditis

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Cellular components related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.9HLA-DRB4, TPO, FASLG, TSHR, ICAM1, CTLA4
2extracellular regionGO:0055767.9CALCA, IFNG, TSHB, FASLG, SERPINA7, TG
3external side of plasma membraneGO:0098977.9CTLA4, IL2RA, IFNG, ICAM1, FASLG, HLA-DRB4
4extracellular spaceGO:0056157.3TPO, TG, SERPINA7, FASLG, ICAM1, IFNG

Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1TPO, TG
2thyroid hormone generationGO:00659010.0TG, TPO
3negative regulation of immune responseGO:05077710.0IL2RA, CTLA4
4leukocyte cell-cell adhesionGO:0071599.7ICAM1, CALCA
5extrinsic apoptotic signaling pathwayGO:0971919.6IFNG, FASLG
6inflammatory response to antigenic stimulusGO:0024379.5IL2RA, HLA-DRB4
7response to vitamin AGO:0331899.5TSHB, SERPINA7
8positive regulation of nitric oxide biosynthetic processGO:0454299.4IFNG, ICAM1
9cell-cell signalingGO:0072679.4FASLG, TSHR, TSHB, CALCA
10negative regulation of T cell proliferationGO:0421309.4HLA-DRB4, IL2RA, CTLA4
11interferon-gamma-mediated signaling pathwayGO:0603339.1IFNG, ICAM1, HLA-DRB4
12cytokine-mediated signaling pathwayGO:0192218.6IFNG, ICAM1, HLA-DRB4
13immune responseGO:0069558.5CTLA4, IL2RA, FASLG, HLA-DRB4, AIRE

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CALCA, TSHB, TG

Products for genes affiliated with Thyroiditis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet