MCID: THY032
MIFTS: 54

Thyroiditis malady

Categories: Endocrine diseases

Aliases & Classifications for Thyroiditis

Aliases & Descriptions for Thyroiditis:

Name: Thyroiditis 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7166
ICD10 33 E06 E06.9
ICD9CM 35 245 245.9
MeSH 42 D013966
NCIt 47 C26894
UMLS 69 C0040147

Summaries for Thyroiditis

MalaCards based summary : Thyroiditis is related to thyroid hormone resistance, autosomal recessive and choreoathetosis, hypothyroidism, and neonatal respiratory distress. An important gene associated with Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Selenium and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Wikipedia : 71 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

Related Diseases for Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1165)
id Related Disease Score Top Affiliating Genes
1 thyroid hormone resistance, autosomal recessive 33.0 SERPINA7 THRB TRH TXNRD2
2 choreoathetosis, hypothyroidism, and neonatal respiratory distress 32.8 RET TG TPO TSHR
3 hypothyroidism, congenital, nongoitrous, 1 32.1 SERPINA7 TG THRB TPO TRH TSHR
4 cowden syndrome 3 31.3 CALCA RET TG
5 endemic goiter 30.6 CALCA FASLG SERPINA7 TG TPO TSHR
6 hepatitis 30.3 CTLA4 IFNG IL2
7 pulsating exophthalmos 28.0 CTLA4 FASLG IFNG SERPINA7 TG THRB
8 autoimmune hemolytic anemia 26.3 CALCA CTLA4 FASLG HT IFNG IL2
9 thyroid cancer 12.4
10 medullary thyroid carcinoma, familial 12.4
11 hashimoto thyroiditis 12.4
12 subacute thyroiditis 12.3
13 thyroid hormone resistance 12.2
14 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 12.2
15 thyroid cancer, monmedullary, 1 12.2
16 thyroid cancer, nonmedullary, 2 12.1
17 thyroid cancer, anaplastic 12.1
18 thyroid crisis 12.1
19 thyroid gland disease 12.1
20 thyroid carcinoma, hurthle cell 12.1
21 thyroid lymphoma 12.1
22 thyroid hormone resistance, selective pituitary 12.1
23 hypothyroidism 12.1
24 subacute lymphocytic thyroiditis 12.0
25 thyroid hormone metabolism, abnormal 12.0
26 thyroid dyshormonogenesis 1 12.0
27 thyroid sarcoma 12.0
28 autoimmune thyroid disease 3 12.0
29 thyroid dyshormonogenesis 3 12.0
30 suppurative thyroiditis 12.0
31 thyroid cancer, nonmedullary, 4 12.0
32 familial thyroid dyshormonogenesis 12.0
33 thyroid cancer, nonmedullary, 5 12.0
34 thyroid angiosarcoma 12.0
35 generalized resistance to thyroid hormone 12.0
36 differentiated thyroid carcinoma 12.0
37 thyroid dyshormonogenesis 2a 12.0
38 acute thyroiditis 11.9
39 thyroid dyshormonogenesis 4 11.9
40 thyroid dyshormonogenesis 5 11.9
41 hyperthyroidism 11.9
42 igg4-related thyroid disease 11.9
43 pendred syndrome 11.9
44 autoimmune thyroid disease 2 11.9
45 thyroid ectopia 11.8
46 familial papillary thyroid carcinoma 11.8
47 thyroid carcinoma, papillary, with papillary renal neoplasia 11.8
48 familial papillary or follicular thyroid carcinoma 11.8
49 mucoepidermoid thyroid carcinoma 11.8
50 multicentric papillary thyroid carcinoma 11.8

Comorbidity relations with Thyroiditis via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to Thyroiditis

Symptoms & Phenotypes for Thyroiditis

MGI Mouse Phenotypes related to Thyroiditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.96 CTLA4 FASLG IFNG IL2 RET TG
2 hematopoietic system MP:0005397 9.85 CTLA4 FASLG IFNG IL2 RET TG
3 homeostasis/metabolism MP:0005376 9.7 TPO TRH TSHR TXNRD2 CTLA4 FASLG
4 neoplasm MP:0002006 9.1 FASLG IFNG IL2 RET THRB TSHR

Drugs & Therapeutics for Thyroiditis

Drugs for Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4,Phase 2 7782-49-2
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Glatiramer Acetate Approved, Investigational Phase 4 147245-92-9 3081884
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5
Xylometazoline Approved Phase 4 526-36-3 5709
6 Trace Elements Phase 4,Phase 3,Phase 2
7 Hormone Antagonists Phase 4
8 Hormones Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Protective Agents Phase 4,Phase 2
11 Micronutrients Phase 4,Phase 3,Phase 2
12 Antirheumatic Agents Phase 4,Phase 1,Phase 2
13 Antioxidants Phase 4,Phase 2
14 glucocorticoids Phase 4
15 Adjuvants, Immunologic Phase 4
16 Immunosuppressive Agents Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Antineoplastic Agents, Hormonal Phase 4
19 Epoetin alfa Phase 4 113427-24-0
20 Hematinics Phase 4
21 methionine Nutraceutical Phase 4
22
Ribavirin Approved Phase 3 36791-04-5 37542
23
Iodine Phase 3 7553-56-2 807
24 cadexomer iodine Phase 3
25 interferons Phase 3
26 Anti-Infective Agents Phase 3,Phase 1,Phase 2
27 Anti-Infective Agents, Local Phase 3
28 Interferon-alpha Phase 3
29 Antimetabolites Phase 3
30 Antiviral Agents Phase 3,Phase 1,Phase 2
31
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
32
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
33 Immunoglobulins Phase 1, Phase 2
34 Antibodies Phase 1, Phase 2
35 Immunoglobulin G Phase 1, Phase 2
36 Autoantibodies Phase 2
37 Anti-HIV Agents Phase 1, Phase 2
38 Anti-Retroviral Agents Phase 1, Phase 2
39
Hydroxychloroquine Approved 118-42-3 3652
40
Triamcinolone Approved, Vet_approved 124-94-7 31307
41
Vigabatrin Approved 68506-86-5, 60643-86-9 5665
42
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
43
Butyric Acid Experimental 107-92-6 264
44 Antimalarials
45 Antiparasitic Agents
46 Antiprotozoal Agents
47 triamcinolone acetonide
48 beta-endorphin
49 Adrenocorticotropic Hormone
50 Triamcinolone diacetate

Interventional clinical trials:

(show top 50) (show all 52)
id Name Status NCT ID Phase
1 Post Partum Thyroiditis 2: Long Term Observations Unknown status NCT00287144 Phase 4
2 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
3 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4
4 Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities Completed NCT01456416 Phase 4
5 Selenium Supplementation in Youths With Autoimmune Thyroiditis Recruiting NCT02644707 Phase 4
6 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4
7 To Study the Efficacy and Safety of Renessans in Chronic HCV Patients Unknown status NCT01463592 Phase 3
8 Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT Unknown status NCT02302768 Phase 2
9 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis Completed NCT01129492 Phase 2
10 Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention) Completed NCT01551498 Phase 2
11 Rituximab in IgG4-related Disease: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2
12 IL-2 in Refractory Autoimmune Encephalitis Not yet recruiting NCT02714959 Phase 1, Phase 2
13 A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1
14 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683
15 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
16 Antiarrythmic Drugs - Long-term Follow-up in the Modern Era Unknown status NCT01082055
17 Hashimoto - a Surgical Disease. Absolute Total Thyroidectomy Makes Antibodies Disappear and Ameliorates Symptoms Unknown status NCT02319538
18 Fetuin A in Hashimoto Thyroiditis Completed NCT01884649
19 Hashimotos Thyroiditis and Thyroid Cancer Completed NCT01428167
20 Oxidative Status in Children With Autoimmune Thyroiditis Completed NCT02318160
21 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421
22 Low Level Laser Therapy for Autoimmune Thyroiditis Completed NCT02240563
23 Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis Completed NCT03114267
24 Selenium Treatment in Autoimmune Thyroiditis (AIT) Completed NCT00271427
25 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487
26 Sonographic and Laboratory Evaluation of the Thyroid Gland in Patients With Systemic Sclerosis Completed NCT01270425
27 Differential Diagnosis of STA-PSV in Thyrotoxicosis Completed NCT01227499
28 Cervarix Long-term Safety Surveillance Completed NCT01498627
29 Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study Completed NCT02798965
30 Association Between Hepatitis C Virus Infection and Hematologic and Thyroid Cancers Completed NCT00342641
31 Autoimmune Thyroid Disease Genetic Study Completed NCT00958113
32 Thyroid in Bariatric Surgery Completed NCT03048708
33 Thyroid Function Throughout Pregnancy With and Without Iodine Supplementation Completed NCT00831402
34 Thyroid Disorders in Malaysia: A Nationwide Multicentre Study Completed NCT02190214
35 Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease Completed NCT01102205
36 Postoperative Hyperthyroidism Completed NCT01095341
37 Selenium Supplementation in Autoimmune Thyroiditis Recruiting NCT02013479
38 Involvement of Polyomaviruses in the Pathogenesis of Autoimmune Thyroiditis and Goitrigenesis. Recruiting NCT03103776
39 ctDNA in Patients With Thyroid Nodules Recruiting NCT02778412
40 Clinical Application of Pulse Rate-monitoring Activity Trackers in Thyrotoxicosis Recruiting NCT03009357
41 The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes Recruiting NCT02575001
42 Effect of Vigabatrin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03003143
43 Antibodies Causing Epilepsy Syndromes: The ACES Study. Recruiting NCT02802475
44 DNA Methylation and Autoimmune Thyroid Diseases Active, not recruiting NCT02491567
45 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Active, not recruiting NCT02287363
46 NeoThyr - the Role of Mitochondria-dysfunction in Newborns of Mothers With Autoimmune Thyroid Disease Active, not recruiting NCT02061111
47 The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan Enrolling by invitation NCT01260532
48 TSH And AMH in Infertile Women Enrolling by invitation NCT02710175
49 FGF-21 Levels and RMR in Children and Adolescents With Hashimoto's Thyroiditis (THYROMETABOL) Not yet recruiting NCT02725879
50 NVC Test in Order to Assess Pathological Changes in Family Members of Patient Diagnosed With SSc Not yet recruiting NCT02795221

Search NIH Clinical Center for Thyroiditis

Cochrane evidence based reviews: thyroiditis

Genetic Tests for Thyroiditis

Genetic tests related to Thyroiditis:

id Genetic test Affiliating Genes
1 Thyroiditis 29

Anatomical Context for Thyroiditis

MalaCards organs/tissues related to Thyroiditis:

39
Thyroid, Lymph Node, Pituitary, Eye, Lung, Testes, T Cells

Publications for Thyroiditis

Articles related to Thyroiditis:

(show top 50) (show all 15474)
id Title Authors Year
1
Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214. ( 28000845 )
2017
2
Changes in thyroid cancer incidence, post-2009 American Thyroid Association guidelines. ( 28092116 )
2017
3
Esophageal Cancer Diagnosed by Thyroid Scintigraphy. ( 28525453 )
2017
4
Solid organ transplant and thyroid cancer. ( 28054336 )
2017
5
The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status. ( 28073128 )
2017
6
Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines. ( 28529619 )
2017
7
Thyroid cancer screening. ( 28534740 )
2017
8
Effect of Thyroid Remnant Volume on the Risk of Hypothyroidism After Hemithyroidectomy: A Prospective Study. ( 28058547 )
2017
9
Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. ( 28400827 )
2017
10
Thyroid Autoimmunity in Girls with Turner Syndrome. ( 28456931 )
2017
11
Classical point mutations of RET, BRAF and RAS oncogenes are not shared in papillary and medullary thyroid cancer occurring simultaneously in the same gland. ( 27535135 )
2017
12
Expression characteristics of proteins of IGF-1R, p-Akt, and survivin in papillary thyroid carcinoma patients with type 2 diabetes mellitus. ( 28328831 )
2017
13
Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with I^-catenin and DNMT1 expression and poor prognosis. ( 28430656 )
2017
14
Genetics of medullary thyroid cancer: An overview. ( 28506408 )
2017
15
Thyroid hormone level is associated with the frequency and severity of Guillain-BarrAc syndrome. ( 28042737 )
2017
16
The relationship between iodine intake and the risk of thyroid cancer: A meta-analysis. ( 28514290 )
2017
17
PAPILLARY THYROID CANCER: THE GOOD AND BAD OF THE "GOOD CANCER". ( 28510505 )
2017
18
Autoimmune comorbidities in Hashimoto's thyroiditis: different patterns of association in adulthood and childhood/adolescence. ( 27913607 )
2017
19
Morbidity of central compartment clearance: Comparison of lesser versus complete clearance in patients with thyroid cancer. ( 28508841 )
2017
20
Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer. ( 27942860 )
2017
21
Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells. ( 28277188 )
2017
22
Current Management of Low Risk Differentiated Thyroid Cancer and Papillary Microcarcinoma. ( 28087101 )
2017
23
Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. ( 28255192 )
2017
24
Basal Serum Calcitonin, After Calcium Stimulation, and in the Needle Washout of Patients with Thyroid Nodules and Mild or Moderate Basal Hypercalcitoninemia. ( 28166595 )
2017
25
Intravoxel incoherent motion magnetic resonance imaging of the normal-appearing parotid glands in patients with differentiated thyroid cancer after radioiodine therapy. ( 28530137 )
2017
26
Management and outcome of clinically evident neck recurrence in patients with papillary thyroid cancer. ( 28516448 )
2017
27
CHI3L1 overexpression is associated with metastasis and is an indicator of poor prognosis in papillary thyroid carcinoma. ( 28009325 )
2017
28
Thyroid cancer: Overdiagnosis of papillary carcinoma - who benefits? ( 28059158 )
2017
29
Diagnostic and Treatment Patterns among Children, Adolescents and Young Adults with Thyroid Cancer in Ontario: 1992-2010. ( 28514192 )
2017
30
Cyp24a1 Attenuation Limits Progression of Braf(V600E) -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF(V600E) Inhibitor PLX4720. ( 28242615 )
2017
31
Knockdown of lncRNA-PANDAR suppresses the proliferation, cell cycle and promotes apoptosis in thyroid cancer cells. ( 28507479 )
2017
32
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
33
Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma. ( 28038712 )
2017
34
Thyroid Storm Precipitated by Diabetic Ketoacidosis and Influenza A: A Case Report and Literature Review. ( 28090049 )
2017
35
MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer. ( 28061868 )
2017
36
Medullary thyroid carcinoma in a patient with Birt-Hogg-Dube syndrome. ( 28242119 )
2017
37
Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods. ( 28528434 )
2017
38
CLINICOPATHOLOGICAL CHARACTERISTICS OF PAPILLARY THYROID CANCER IN CHILDREN WITH EMPHASIS ON THE PUBERTAL STATUS AND ASSOCIATION WITH BRAFV600E MUTATION. ( 28077340 )
2017
39
Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. ( 28076499 )
2017
40
HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis. ( 28081700 )
2017
41
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. ( 28504713 )
2017
42
Thyroid hormone induce a p53-dependent DNA damage through PI3K/Akt activation in sperm. ( 28322991 )
2017
43
High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies. ( 28099999 )
2017
44
MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancer. ( 28523498 )
2017
45
De novo thyroid cancer following solid organ transplantation-A 25-year experience at a high-volume institution with a review of the literature. ( 28054345 )
2017
46
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. ( 28315909 )
2017
47
The relationship between thyroid function and metabolic changes in Chinese women with polycystic ovary syndrome. ( 28051891 )
2017
48
(99)Tc(m)-octreotide scintigraphy and serum eye muscle antibodies in evaluation of active thyroid-associated ophthalmopathy. ( 28387769 )
2017
49
Association of microRNA-related gene XPO5 rs11077 polymorphism with susceptibility to thyroid cancer. ( 28383405 )
2017
50
Surgical outcomes of unilateral recession-resection for vertical strabismus in patients with thyroid eye disease. ( 28089937 )
2017

Variations for Thyroiditis

Expression for Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for Thyroiditis

Pathways related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 CTLA4 FASLG IFNG IL2 TG TPO
2 12.27 CTLA4 FASLG IFNG IL2
3
Show member pathways
12.12 SERPINA7 TG TPO TSHB TSHR
4 11.85 CALCA TSHB TSHR
5
Show member pathways
11.72 FASLG IFNG IL2
6
Show member pathways
11.44 CTLA4 FASLG IFNG IL2
7
Show member pathways
11.39 FASLG IFNG IL2
8 11.29 FASLG IFNG IL2
9
Show member pathways
11.15 FASLG IFNG IL2
10 11.11 CALCA FASLG IFNG THRB
11 10.57 TSHB TSHR
12 9.7 TG TPO TRH TSHR

GO Terms for Thyroiditis

Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CALCA FASLG IFNG IL2 PRSS3 SERPINA7
2 extracellular space GO:0005615 9.23 CALCA FASLG IFNG IL2 PRSS3 SERPINA7

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.43 IFNG RET
2 response to pain GO:0048265 9.4 CALCA RET
3 hormone biosynthetic process GO:0042446 9.37 TG TPO
4 positive regulation of adenylate cyclase activity GO:0045762 9.32 CALCA TSHR
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 IFNG IL2
6 inflammatory cell apoptotic process GO:0006925 9.16 FASLG IFNG
7 hormone-mediated signaling pathway GO:0009755 9.13 TRH TSHB TSHR
8 cell-cell signaling GO:0007267 9.1 CALCA FASLG IL2 TRH TSHB TSHR

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CALCA TG TRH TSHB

Sources for Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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