MCID: THY032
MIFTS: 67

Thyroiditis malady

Endocrine diseases category

Summaries for Thyroiditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards: Thyroiditis is related to thyroid cancer and papillary carcinoma. An important gene associated with Thyroiditis is THRB (thyroid hormone receptor, beta), and among its related pathways are Insulin secretion and Allograft rejection. The compounds tyrosine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Thyroiditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroiditis 8 10 44 60


External Ids:

Disease Ontology8 DOID:7166
ICD9CM27 245.8
ICD1025 E06, E06.9

Related Diseases for Thyroiditis

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17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis
thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1069)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer31.9CCDC6, NKX2-1, TPO, TSHR, THRB, DUOX1
2papillary carcinoma31.9NKX2-1, DUOX1, TSHR, TPO
3papillary thyroid carcinoma31.9TSHR, CCDC6, TPO
4autoimmune thyroiditis31.8TSHR, TPO, LMOD1
5follicular thyroid carcinoma31.5THRB, TSHR
6subacute thyroiditis31.4TSHR, TPO
7adenoma31.4CGA, NKX2-1, PKM, DUOX1, DUOX2, LMOD1
8goiter31.4TPO, TSHR, TSHB, THRB, LMOD1, NKX2-1
9hypothyroidism31.4TPO, NKX2-1, TSHR
10graves' disease31.4CGA, TPO, TSHR, THRB, LMOD1, FOXE1
11hyperthyroidism31.2TPO, TSHR, CGA, LMOD1, TSHB, THRB
12thyrotoxicosis31.1THRB, TSHR, TPO
13congenital hypothyroidism31.1DUOX1, FOXE1, DUOX2, NKX2-1, TSHR, TPO
14follicular adenoma31.0TPO, NKX2-1, LMOD1, TSHR
15multinodular goiter30.9TPO, TSHR
16endemic goiter30.9TPO, TSHR
17nodular goiter30.9TSHR, TPO
18myxedema30.8TSHR, TPO
19struma ovarii30.7TSHR, NKX2-1
20nontoxic goiter30.6TSHR, TPO
21breast cancer30.6THRB, MED1, LMOD1, NCOR2
22pendred syndrome30.5TPO, DUOX2
23hyperthyroxinemia30.4TPO, TSHR
24lung cancer30.4NKX2-1
25thyroid cancer, anaplastic30.3TSHR, NKX2-1, TPO
26thyroid agenesis30.2TSHR, NKX2-1, FOXE1
27toxic diffuse goiter29.6TSHR, TPO
28thyrotropin deficiency, isolated29.4TPO, TSHB
29thyroid medullary carcinoma11.1
30acute thyroiditis10.9
31thyroid lymphoma10.9
32suppurative thyroiditis10.8
33familial medullary thyroid carcinoma10.7
34eye disease10.7
35hepatitis10.7
36adenocarcinoma10.6
37cervicitis10.6
38thyroid crisis10.6
39thyroid hormone resistance syndrome10.5
40diabetes mellitus10.5
41hepatitis c10.5
42papillary adenoma10.5
43lymph node cancer10.5
44papillary adenocarcinoma10.5
45parathyroid adenoma10.5
46thyroid gland disease10.4
47hyperparathyroidism10.4
48obesity10.4
49mucoepidermoid thyroid carcinoma10.4
50type 1 diabetes mellitus10.4

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Clinical Features for Thyroiditis

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Drugs & Therapeutics for Thyroiditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Search CenterWatch for Thyroiditis

Genetic Tests for Thyroiditis

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Anatomical Context for Thyroiditis

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32MalaCards
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MalaCards organs/tissues related to Thyroiditis:

32
Thyroid, Lymph node, Pituitary, Eye, Lung, Testes, T cells, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Heart, Kidney, Ovary, Colon, Thymus, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Monocytes, Skeletal muscle, Testis, Salivary gland, Fetal thyroid, Placenta, Prostate, Spinal cord, Smooth muscle, Trachea, Cortex, Cervix, Tongue, Fetal brain, Adrenal gland, Myeloid, Retina, Temporal lobe, Cardiac myocytes, Cerebellum, Whole blood, Spleen, Nk cells, Appendix, Fetal lung, Atrioventricular node, Tonsil

Animal Models for Thyroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076813.2NCOR2, NKX2-1, MED1, FOXE1, PKM, TRIP13
2MP:000537613.1FOXE1, MED1, CGA, NKX2-1, NCOR2, DUOX2
3MP:000537912.7TPO, FOXE1, MED1, CGA, NKX2-1, DUOX2
4MP:000537812.7NCOR2, NKX2-1, CGA, MED1, DUOX2, TRIP13

Publications for Thyroiditis

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50PubMed
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Articles related to Thyroiditis:

(show top 50)    (show all 13308)
idTitleAuthorsYear
1
Aspiration cytology in the preoperative diagnosis of granular cell tumor of thyroid region in an 11-years-old female child. (24130422)
2013
2
DNA methylation of MAPK signal-inhibiting genes in papillary thyroid carcinoma. (24222120)
2013
3
Clinicopathologic study and outcome analysis of thyroid lymphomas: experience from a tertiary cancer center. (22368156)
2013
4
Annual increase in the frequency of papillary thyroid carcinoma as diagnosed by fine-needle aspiration at a cytology unit in Sicily. (23624131)
2013
5
Prevalence of thyroid function test abnormalities and thyroid autoantibodies in children with vitiligo. (24381891)
2013
6
Expression of decoy receptor 3 in diffuse sclerosing variant of papillary thyroid carcinoma: correlation with M2 macrophage differentiation and lymphatic invasion. (23186064)
2013
7
Small cell lung cancer with metastasis to the thyroid in a patient with toxic multinodular goiter. (23172496)
2012
8
The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study. (23066120)
2012
9
Serum oncofetal fibronectin (onfFN) mRNA in differentiated thyroid carcinoma (DTC): large overlap between disease-free and metastatic patients. (23098431)
2012
10
Thyroid cancer detection with dual-isotope parathyroid scintigraphy in primary hyperparathyroidism. (22395991)
2012
11
Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer. (22535643)
2012
12
A patient with thyroid storm presenting with apathetic thyrotoxicosis and features of meningoencephalitis. (21449770)
2011
13
Indolent medullary thyroid cancer with a RET proto-oncogene Cys618Phe mutation presenting as sporadic unilateral pheochromocytoma in a 55-year-old Korean woman. (21254918)
2011
14
Recurrent partial seizures with ictal yawning as atypical presentation of Hashimoto's encephalopathy (steroid-responsive encephalopathy associated with autoimmune thyroiditis). (22030535)
2011
15
Selenium supplementation does not decrease thyroid peroxidase antibody concentration in children and adolescents with autoimmune thyroiditis. (20526530)
2010
16
Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling. (20200966)
2010
17
Diagnostic value of estrogen receptors in thyroid lesions. (20581768)
2010
18
Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen. (19375891)
2009
19
Effects of thyroid hormone on the adaptation in short bowel syndrome. (19111325)
2009
20
Thyroid disorders and occurrence of nonorgan-specific autoantibodies (NOSA) in patients with chronic hepatitis C before and during antiviral induction therapy with consensus interferon (interferon alfacon-1). (19247202)
2009
21
Silent parathyroid adenoma mistakenly interpreted on FDG-PET as thyroid cancer metastasis in a patient with elevated thyroglobulin and negative I-131 whole body scan and removed by radioguided minimally invasive surgery. (18097251)
2008
22
Cutaneous ulceration in thyroid lymphoma. (18652536)
2008
23
Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction. (18466078)
2008
24
Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer: a retrospective analysis of seventy-three patients. (17084554)
2007
25
Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA). (16452550)
2006
26
Erythema elevatum diutinum associated with Hashimoto's thyroiditis and antiphospholipid antibodies. (15627103)
2005
27
The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. (15771616)
2005
28
Decreased expression of haemoglobin beta (HBB) gene in anaplastic thyroid cancer and recovery of its expression inhibits cell growth. (15956966)
2005
29
Autonomously functioning thyroid nodules are not associated with BRAF mutations. (15009007)
2004
30
PET in the follow-up of differentiated thyroid cancer. (14512328)
2003
31
Serum levels of angiogenic growth factors in patients with thyroid gland tumors and parathyroid adenoma. (15073567)
2003
32
Neurodevelopmental control by thyroid hormone receptors. (11861164)
2002
33
Thyroid cystadenocarcinoma in a saker falcon (Falco cherrug). (11558665)
2001
34
Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B. (11720884)
2001
35
Study of matrix metalloproteinase-2 and -9 in thyroid papillary cancer]. (10853337)
2000
36
Thyroid function in children with diagnosed chronic hepatitis B treated with interferon alpha]. (10967911)
2000
37
L-thyroxine directly affects expression of thyroid hormone-sensitive genes: regulatory effect of RXRbeta. (9406846)
1997
38
Pertechnetate thyroid uptake is not always suppressed in patients with subacute thyroiditis. (9031769)
1997
39
T cells and thyroid autoimmunity. (8169877)
1994
40
Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells. (8473345)
1993
41
Retinoic acid inhibits human thyroid peroxidase and thyroglobulin gene expression in cultured human thyrocytes. (8463554)
1993
42
Acute suppurative thyroiditis complicating second allogeneic transplant for juvenile CMML. (1490204)
1992
43
Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. (1672289)
1991
44
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
45
Thyroid hormones changes in infants and children with metabolic acidosis. (1761806)
1991
46
Follicular thyroid carcinoma with pulmonary metastasis. (2948942)
1986
47
Thyroxine-binding globulin deficiency in early childhood. Postnatal changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins. (6785995)
1981
48
The thyroid gland in kwashiorkor: a pathologic study. (1046462)
1975
49
True thyroid adenoma. (4116348)
1972
50
The effect of thyroid therapy on the hyponatremia and hypoosmolality of myxedema. (5414953)
1970

Genetic Variations for Thyroiditis

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Expression for genes affiliated with Thyroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Thyroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CGA, DUOX2, TSHB, TSHR
2
Hide members
11.2TPO, TSHR, TSHB
3
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11.0TSHR, TSHB
411.0NCOR2, MED1

Compounds for genes affiliated with Thyroiditis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB
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Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tyrosine4413.1CCDC6, BRD8, NKX2-1, NCOR2, PKM, LMOD1
2estrogen4412.8MED1, CGA, NKX2-1, NCOR2, LMOD1, THRB
3iodide44 2413.6TPO, FOXE1, NKX2-1, DUOX1, DUOX2, LMOD1
4triiodothyronine4412.6CGA, NCOR2, LMOD1, THRB, TSHB, TSHR
5retinoic acid44 2413.5MED1, NKX2-1, NCOR2, THRB, TSHB, TSHR
6thyroxine44 2413.3CGA, LMOD1, THRB, TSHB, TSHR, TPO
7ribonucleic acid4412.3CGA, NKX2-1, THRB, TSHB, TSHR, TPO
8steroid4412.3MED1, CGA, NKX2-1, NCOR2, THRB, TPO
9alanine4412.2FOXE1, MED1, CGA, PKM, THRB, TSHR
10sodium44 2413.0FOXE1, NKX2-1, DUOX2, TSHR, TPO
11progesterone44 59 28 11 2415.9CGA, NKX2-1, NCOR2, THRB, TSHR
12sodium iodide4411.8NKX2-1, DUOX2, TSHR, TPO
13iodine44 2412.8DUOX2, LMOD1, TSHR, TPO
14retinoid4411.7MED1, NCOR2, THRB, TSHB
15vitamin d4411.6MED1, CGA, NCOR2, THRB
16propylthiouracil44 2 1113.6LMOD1, TSHR, TPO
17amiodarone44 49 28 1114.5TPO, THRB, LMOD1
18125i4411.5LMOD1, TSHR, TPO
19estradiol44 11 2413.4MED1, CGA, NCOR2, TSHR
20Dextrothyroxine1111.2TPO, THRB
21forskolin44 49 1113.2TPO, TSHR, NKX2-1, CGA
22perchlorate4411.2TPO, DUOX2
23carbimazole44 1112.2TPO, TSHR
24Liothyronine11 2412.0TPO, THRB
25amino acid4411.0TPO, TSHR
26maltose44 1112.0TPO, TSHR

GO Terms for genes affiliated with Thyroiditis

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16Gene Ontology
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Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659012.2TPO, DUOX2, DUOX1, CGA, MED1, FOXE1
2negative regulation of transcription from RNA polymerase II promoterGO:00012211.7THRB, NCOR2, NKX2-1, MED1, FOXE1
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.4THRB, HMGN3, NKX2-1, CGA, MED1
4hormone biosynthetic processGO:04244611.4DUOX1, DUOX2, TPO
5thyroid gland developmentGO:03087811.4NKX2-1, CGA, FOXE1
6hydrogen peroxide catabolic processGO:04274411.3TPO, DUOX2, DUOX1
7cuticle developmentGO:04233511.0DUOX1, DUOX2
8embryonic hemopoiesisGO:03516211.0TPO, MED1
9peptide hormone processingGO:01648610.9CGA, TSHB

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor bindingGO:04696611.5ZNHIT3, HMGN3, TRIP12, MED1
2peroxidase activityGO:00460111.2TPO, DUOX2, DUOX1
3heme bindingGO:02003711.2TPO, DUOX2, DUOX1
4NAD(P)H oxidase activityGO:01617410.9DUOX1, DUOX2
5thyroid hormone receptor activityGO:00488710.7THRB, BRD8

Products for genes affiliated with Thyroiditis

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Sources for Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet