MCID: THY032
MIFTS: 61

Thyroiditis malady

Endocrine category

Summaries for Thyroiditis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards: Thyroiditis is related to thyroid cancer and papillary carcinoma. An important gene associated with Thyroiditis is THRB (thyroid hormone receptor, beta), and among its related pathways are Insulin secretion and Allograft rejection. The compounds tyrosine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Thyroiditis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

thyroiditis 8 10 45 61


External Ids:

Disease Ontology8 DOID:7166
ICD9CM27 245.8
ICD1025 E06, E06.9

Related Diseases for Thyroiditis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the autoimmune thyroiditis family:

acute thyroiditis subacute thyroiditis
thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 985)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer31.9TSHR, NKX2-1, TPO
2papillary carcinoma31.9NKX2-1, DUOX1, TSHR, TPO
3autoimmune thyroiditis31.6TSHR, TPO, LMOD1
4adenoma31.5CGA, NKX2-1, PKM, DUOX1, DUOX2, LMOD1
5subacute thyroiditis31.5TSHR, TPO
6graves' disease31.4CGA, TPO, TSHR, THRB, LMOD1, FOXE1
7thyrotoxicosis31.1THRB, TSHR, TPO
8congenital hypothyroidism31.1DUOX1, FOXE1, DUOX2, NKX2-1, TSHR, TPO
9thyroid cancer, anaplastic31.0TSHR, NKX2-1, TPO
10multinodular goiter31.0TPO, TSHR
11endemic goiter30.9TPO, TSHR
12nodular goiter30.9TSHR, TPO
13myxedema30.8TSHR, TPO
14struma ovarii30.7TSHR, NKX2-1
15nontoxic goiter30.7TSHR, TPO
16thyroid agenesis30.6TSHR, NKX2-1, FOXE1
17pendred syndrome30.6TPO, DUOX2
18hyperthyroxinemia30.5TPO, TSHR
19pituitary tumors30.2TSHB
20toxic diffuse goiter29.7TSHR, TPO
21thyrotropin deficiency, isolated29.7TPO, TSHB
22thyroid medullary carcinoma11.1
23thyroid adenoma11.0
24thyroid lymphoma10.9
25acute thyroiditis10.8
26suppurative thyroiditis10.8
27familial medullary thyroid carcinoma10.7
28adenocarcinoma10.7
29multiple endocrine neoplasia10.6
30thyroid crisis10.6
31hepatitis c10.6
32hepatitis a10.6
33papillary adenoma10.6
34n syndrome10.6
35riedel thyroiditis10.6
36thyroid hormone resistance syndrome10.6
37hepatitis d10.5
38thyroid gland disease10.5
39mucoepidermoid thyroid carcinoma10.5
40teratoma10.5
41mucoepidermoid carcinoma10.4
42hypothyroidism, autoimmune10.4
43squamous cell carcinoma10.4
44pheochromocytoma10.4
45parathyroid carcinoma10.4
46paraganglioma10.4
47thyroid hurthle cell carcinoma10.4
48primary hyperparathyroidism10.4
49autoimmune hepatitis10.4
50familial papillary thyroid carcinoma10.4

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Clinical Features for Thyroiditis

Drugs & Therapeutics for Thyroiditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Search CenterWatch for Thyroiditis

Genetic Tests for Thyroiditis

Anatomical Context for Thyroiditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Thyroiditis:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Colon, Thyroid, Salivary gland, Adrenal gland, Breast, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Hypothalamus, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pituitary

Animal Models for Thyroiditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Thyroiditis

Sources:
51PubMed
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Articles related to Thyroiditis:

(show top 50)    (show all 1815)
idTitleAuthorsYear
1
Painless thyroiditis in drug-induced hypersensitivity syndrome with prolonged reactivation of herpesviruses. (22804722)
2013
2
Influence of chronic autoimmune thyroiditis and papillary thyroid cancer on serum calcitonin levels. (23327335)
2013
3
Autoimmune thyroiditis-associated encephalopathy without clinical steroid-responsiveness and recovery after cyclophosphamide. (23487210)
2013
4
Hashimoto's thyroiditis associated with idiopathic portal hypertension. (23535860)
2013
5
Diagnostic usefulness of fragments of crushed cells in autoimmune thyroiditis. (22619158)
2012
6
A newly identified TSHI^ splice variant is involved in the pathology of Hashimoto's thyroiditis. (22752807)
2012
7
Is thyroidectomy in patients with Hashimoto thyroiditis more risky? (23043868)
2012
8
Skin autoreactivity in Hashimoto's thyroiditis patients without urticaria: autologous serum skin test positivity correlation with thyroid antibodies, sonographical volume and grading. (22503840)
2012
9
Comments on "well-differentiated thyroid carcinoma with concomitant Hashimoto's thyroiditis present with less aggressive clinical stage and low recurrence". (21728067)
2011
10
The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating interleukin-6, but not of tumor necrosis factor-alpha. (21385538)
2011
11
The genetics of autoimmune thyroiditis: the first decade. (21683550)
2011
12
A case of thyroiditis during natalizumab therapy for multiple sclerosis. (21677508)
2011
13
Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis. (21151525)
2010
14
A comparison between two imaging techniques for the diagnosis of subacute thyroiditis (de Quervain thyroiditis): brief communication. (20940543)
2010
15
Subacute thyroiditis presenting as fever of unknown origin. (17956558)
2010
16
Selenium supplementation in autoimmune thyroiditis female patient--effects on thyroid and ovarian functions (case study). (18679588)
2008
17
Thyrocytes contribute to their own demise: the role of interleukin-18 in Hashimoto's thyroiditis]. (19080488)
2008
18
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
19
Glucocorticoid response in amiodarone-induced thyrotoxicosis resulting from destructive thyroiditis is predicted by thyroid volume and serum free thyroid hormone concentrations. (17148557)
2007
20
Cervical lymphadenitis, suppurative parotitis, thyroiditis, and infected cysts. (17561081)
2007
21
A variant of thyrotoxicosis associated with chronic thyroiditis characterized by prolonged fever, absence of anti-thyroidal antibodies, and favorable response to naproxen. (17505175)
2007
22
Incidence of iodine deficiency in patients presenting with goitre--discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis--clinical, hormonal and urinary iodine excretion studies. (16509527)
2006
23
Prevalence of chronic autoimmune thyroiditis in the urban area neighboring a petrochemical complex and a control area in Sao Paulo, Brazil. (16924321)
2006
24
Thyroid function, autoimmune thyroiditis and coeliac disease in juvenile idiopathic arthritis. (15695302)
2005
25
Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto's encephalitis? (14616889)
2003
26
Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes. (12605664)
2003
27
Localized granuloma annulare and autoimmune thyroiditis in adult women: a case-control study. (12664012)
2003
28
A role for IL-15 in driving the onset of spontaneous autoimmune thyroiditis? (11937583)
2002
29
Hashimoto's thyroiditis and Graves' disease associated with retroperitoneal fibrosis. (12481950)
2002
30
Serum monocyte chemoattractant protein-1 is increased in chronic autoimmune thyroiditis. (12404203)
2002
31
Acute suppurative thyroiditis. (11374641)
2001
32
Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: thyroiditis transfer with Vbeta8+ T cells. (11716530)
2001
33
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. (11129116)
2000
34
Henoch-SchAPnlein purpura in adults and autoimmune thyroiditis. (10813317)
2000
35
Sweet's syndrome and subacute thyroiditis. (10727568)
2000
36
Adoptive transfer murine model of granulomatous experimental autoimmune thyroiditis. (11129114)
2000
37
Fibrosing mediastinitis associated with Riedel's thyroiditis--computed tomographic findings: case report. (9879270)
1998
38
Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. (9020075)
1997
39
Anti-heat shock proteins autoantibodies in autoimmune thyroiditis. Preliminary study. (9505212)
1997
40
Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy. (8980891)
1996
41
Studies of human peripheral blood mononuclear cells (PBMC) from patients with subacute thyroiditis in severe combined immunodeficient (SCID) mice: less production of human interferon gamma than that seen for Graves' disease. (7835825)
1994
42
Monoclonal gammopathy as a clue to the presence of thyroid lymphoma associated with auto-immune thyroiditis. (1445050)
1992
43
The incidence of thyroid stimulating blocking antibodies during the hypothyroid phase in patients with subacute thyroiditis. (1856259)
1991
44
Transitory subclinical and permanent hypothyroidism in the course of subacute thyroiditis (de Quervain). (6428116)
1984
45
Pathological and echographic features of painful and painless subacute thyroiditis. Clinical delineation of a pseudocystic variant. (7156842)
1982
46
Acute suppurative thyroiditis. Report of two cases including one caused by Mycobacterium intracellulare (Battey bacillus). (4715789)
1973
47
TREATMENT OF GRANULOMATOUS (SUBACUTE) THYROIDITIS. (14161711)
1964
48
SUBACUTE THYROIDITIS OF DE QUERVAIN. (14044864)
1963
49
Acute non-suppurative thyroiditis. (14911045)
1952
50
Acute and subacute thyroiditis. (15425440)
1950

Genetic Variations for Thyroiditis

Expression for genes affiliated with Thyroiditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Thyroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CGA, DUOX2, TSHB, TSHR
2
Hide members
11.2TSHB, TSHR, TPO
3
Hide members
11.0TSHB, TSHR
411.0MED1, NCOR2

Compounds for genes affiliated with Thyroiditis

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tyrosine4513.1CCDC6, BRD8, NKX2-1, NCOR2, PKM, LMOD1
2estrogen4512.8MED1, CGA, NKX2-1, NCOR2, LMOD1, THRB
3iodide45 2413.6TPO, FOXE1, NKX2-1, DUOX1, DUOX2, LMOD1
4triiodothyronine4512.6CGA, NCOR2, LMOD1, THRB, TSHB, TSHR
5retinoic acid45 2413.5MED1, NKX2-1, NCOR2, THRB, TSHB, TSHR
6thyroxine45 2413.3CGA, LMOD1, THRB, TSHB, TSHR, TPO
7ribonucleic acid4512.3CGA, NKX2-1, THRB, TSHB, TSHR, TPO
8steroid4512.3MED1, CGA, NKX2-1, NCOR2, THRB, TPO
9alanine4512.2FOXE1, MED1, CGA, PKM, THRB, TSHR
10sodium45 2413.0FOXE1, NKX2-1, DUOX2, TSHR, TPO
11progesterone45 60 29 11 2415.9CGA, NKX2-1, NCOR2, THRB, TSHR
12sodium iodide4511.8NKX2-1, DUOX2, TSHR, TPO
13iodine45 2412.8DUOX2, LMOD1, TSHR, TPO
14retinoid4511.7MED1, NCOR2, THRB, TSHB
15vitamin d4511.6MED1, CGA, NCOR2, THRB
16propylthiouracil45 2 1113.6LMOD1, TSHR, TPO
17amiodarone45 50 29 1114.5TPO, THRB, LMOD1
18125i4511.5LMOD1, TSHR, TPO
19estradiol45 11 2413.4MED1, CGA, NCOR2, TSHR
20Dextrothyroxine1111.2TPO, THRB
21forskolin45 50 1113.2TPO, TSHR, NKX2-1, CGA
22perchlorate4511.2TPO, DUOX2
23carbimazole45 1112.2TPO, TSHR
24Liothyronine11 2412.0TPO, THRB
25amino acid4511.0TPO, TSHR
26maltose45 1112.0TPO, TSHR

GO Terms for genes affiliated with Thyroiditis

Sources:
16Gene Ontology
See all sources

Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659012.2TPO, DUOX2, DUOX1, CGA, MED1, FOXE1
2negative regulation of transcription from RNA polymerase II promoterGO:00012211.7THRB, NCOR2, NKX2-1, MED1, FOXE1
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.4THRB, HMGN3, NKX2-1, CGA, MED1
4hormone biosynthetic processGO:04244611.4DUOX1, DUOX2, TPO
5thyroid gland developmentGO:03087811.4NKX2-1, CGA, FOXE1
6hydrogen peroxide catabolic processGO:04274411.3TPO, DUOX2, DUOX1
7cuticle developmentGO:04233511.0DUOX1, DUOX2
8embryonic hemopoiesisGO:03516211.0TPO, MED1
9peptide hormone processingGO:01648610.9CGA, TSHB

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor bindingGO:04696611.5MED1, TRIP12, HMGN3, ZNHIT3
2peroxidase activityGO:00460111.2TPO, DUOX1, DUOX2
3heme bindingGO:02003711.2DUOX2, DUOX1, TPO
4NAD(P)H oxidase activityGO:01617410.9DUOX2, DUOX1
5thyroid hormone receptor activityGO:00488710.7BRD8, THRB

Products for genes affiliated with Thyroiditis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroiditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet