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12Gene Ontology
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Cellular components related to thyroiditis according to GeneDecks: (show all 14)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | nucleoplasm | GO:005654 | 53.3 | PIN1, RFC1, NCOA1, NCOA2, NCOA3, NCOA6 | | 2 | integral to plasma membrane | GO:005887 | 47.1 | LRP1, RET, CNR2, VSIG2, SELP, LPAR1 | | 3 | membrane | GO:016020 | 31.9 | PIK3CG, LRRC1, PDE4A, RECK, REN, VSIG2 | | 4 | perinuclear region of cytoplasm | GO:048471 | 26.6 | PICALM, PDE4A, PCSK1, BUB1B, GC, SELE | | 5 | transcription factor complex | GO:005667 | 19.9 | KLF4, NCOA6, RELA, RBL2, RBM14, NAA15 | | 6 | membrane raft | GO:045121 | 16.7 | SELE, BSG, RAB5A, UMOD, LCK, P2RX7 | | 7 | cytosol | GO:005829 | INF | PIK3CB, PIK3CA, PIP5K1C, PIK3R1, PIK3C2A, PIK3CG | | 8 | extracellular region | GO:005576 | INF | PI15, LRPAP1, NCAM1, RETN, CNTN4, KISS1 | | 9 | extracellular space | GO:005615 | INF | LRP2, RELN, REN, KIT, KITLG, VTN | | 10 | cell surface | GO:009986 | INF | LRPAP1, NCAM1, KISS1R, PCSK6, VEGFA, LPAR1 | | 11 | nucleus | GO:005634 | INF | ZNF197, ZNF331, ZNF71, ZNF131, ZNF138, ZNF135 | | 12 | external side of plasma membrane | GO:009897 | INF | NCAM1, KIT, VWF, SELP, VCAM1, LILRB1 | | 13 | plasma membrane | GO:005886 | INF | PIK3R1, PIK3C2A, PIK3CG, LRP2, LRPAP1, NCAM1 | | 14 | cytoplasm | GO:005737 | INF | PIK3C2A, PIK3CG, PIN1, LRP1, LRRC1, LRRC6 |
Biological processes related to thyroiditis according to GeneDecks: (show top 50)
(show all 67)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | positive regulation of transcription from RNA polymerase II promoter | GO:045944 | INF | KLF4, NCOA1, NCOA2, NCOA3, NCOA6, NCOA7 | | 2 | immune response | GO:006955 | INF | CNIH, CNR2, VTN, BMP6, , LIF | | 3 | transforming growth factor beta receptor signaling pathway | GO:007179 | INF | KLF10, NCOR1, NCOR2, RBL1, SERPINE1, MYC | | 4 | signal transduction | GO:007165 | 54.4 | PIK3CB, PDE10A, PDE1A, PDE1C, PDE4A, RET | | 5 | small molecule metabolic process | GO:044281 | 53.8 | PIK3CB, PIK3CA, PIP5K1C, PIK3R1, PIK3C2A, PIK3CG | | 6 | blood coagulation | GO:007596 | 36.8 | PIK3CB, PIK3CA, PIK3R1, PIK3CG, PDE10A, PDE1A | | 7 | positive regulation of cell proliferation | GO:008284 | 34.5 | KIT, BTC, NBN, VIP, NAMPT, VEGFA | | 8 | negative regulation of cell proliferation | GO:008285 | 31.5 | KLF10, KLF4, NDN, KISS1R, SFN, RBBP4 | | 9 | response to drug | GO:042493 | 30.7 | LRP2, PDE4A, REN, PCSK1, NBN, SERPINA7 | | 10 | cell proliferation | GO:008283 | 27.5 | LRP2, KLF10, KITLG, SFN, PCNA, BUB1 | | 11 | inflammatory response | GO:006954 | 26.9 | PIK3CG, RELA, CNR2, KIT, SELE, SELP | | 12 | transcription initiation from RNA polymerase II promoter | GO:006367 | 26.2 | NCOA6, NCOR1, NCOR2, RBL1, SERPINE1, VDR | | 13 | anti-apoptosis | GO:006916 | 24.9 | PIK3CA, RELA, SERPINB2, BRAF, VHL, VEGFB | | 14 | nerve growth factor receptor signaling pathway | GO:048011 | 24.6 | PIK3CB, PIK3CA, PIK3R1, NDN, PDE1A, PDE1C | | 15 | positive regulation of apoptotic process | GO:043065 | 22.3 | NCOA1, LPAR1, BMP2, RARG, RARB, RAD9A | | 16 | fibroblast growth factor receptor signaling pathway | GO:008543 | 21.5 | PIK3CA, PIK3R1, PDE1A, PDE1C, BRAF, RAF1 | | 17 | epidermal growth factor receptor signaling pathway | GO:007173 | 21.2 | PIK3CA, PIK3R1, PIK3C2A, PDE1A, PDE1C, RAF1 | | 18 | response to lipopolysaccharide | GO:032496 | 20.4 | CNR2, SFTPB, SFTPC, PCSK1, SELE, SELP | | 19 | heart development | GO:007507 | 20.0 | NCOA6, PCNA, PCSK5, RBP4, VCAM1, BMP2 | | 20 | protein autophosphorylation | GO:046777 | 19.8 | KIT, PAK1, KDR, MTOR, AURKA, AURKB | | 21 | cell cycle arrest | GO:007050 | 19.7 | RB1, NBN, MYC, RASSF1, MSH2, ATM | | 22 | positive regulation of cell migration | GO:030335 | 19.2 | RET, VEGFA, BMP2, KDR, BCAR1, LEF1 | | 23 | aging | GO:007568 | 19.0 | LRP2, SERPINA7, VDR, VCAM1, UCP3, BAK1 | | 24 | positive regulation of gene expression | GO:010628 | 18.6 | NCOA3, KIT, BRAF, VEGFA, VDR, BMP2 | | 25 | negative regulation of neuron apoptotic process | GO:043524 | 18.6 | BRAF, VEGFB, RASA1, LIG4, PARK7, BDNF | | 26 | positive regulation of MAPK cascade | GO:043410 | 18.3 | KIT, LPAR1, LPAR2, LIF, KDR, LEP | | 27 | response to estradiol stimulus | GO:032355 | 18.1 | NCOA1, GC, SERPINA1, VDR, RARA, UCN | | 28 | response to glucocorticoid stimulus | GO:051384 | 18.1 | SFTPB, SFTPC, PCK2, PCSK1, SERPINE1, BGLAP | | 29 | activation of MAPK activity | GO:000187 | 17.9 | PIK3CB, KIT, LPAR1, LPAR2, UBC, P2RX7 | | 30 | positive regulation of ERK1 and ERK2 cascade | GO:070374 | 17.4 | GCG, BRAF, VEGFB, BMP2, KDR, P2RY1 | | 31 | MAPK cascade | GO:000165 | 17.3 | RET, MYC, RAF1, PAK1, SCG2, CDK1 | | 32 | leukocyte migration | GO:050900 | 17.1 | PIK3CB, PIK3CA, PIK3R1, SELP, BSG, LCK | | 33 | organ regeneration | GO:031100 | 16.8 | LRP2, LIF, LEF1, UGT1A1, BAK1, CDKN1A | | 34 | interferon-gamma-mediated signaling pathway | GO:060333 | 16.5 | NCAM1, VCAM1, CIITA, MT2A, B2M, JAK1 | | 35 | positive regulation of protein kinase B signaling cascade | GO:051897 | 16.4 | PIK3CG, VEGFB, MTDH, MTOR, AXL, MST1R | | 36 | positive regulation of peptidyl-tyrosine phosphorylation | GO:050731 | 16.0 | RELN, KITLG, VTN, VEGFA, VEGFB, LIF | | 37 | positive regulation of cell division | GO:051781 | 15.9 | BTC, VEGFA, VEGFB, VEGFC, YBX1, FIGF | | 38 | response to wounding | GO:009611 | 15.9 | VWF, RAC1, ITGB4, FN1, FGF7, MET | | 39 | positive regulation of phosphatidylinositol 3-kinase cascade | GO:014068 | 15.6 | RELN, KIT, SELP, KDR, JAK2, FLT1 | | 40 | apoptotic process | GO:006915 | INF | PDCD5, KIAA0141, SFN, BUB1, BUB1B, RBM25 | | 41 | negative regulation of transcription from RNA polymerase II promoter | GO:000122 | INF | KLF10, KLF4, NCOA2, NCOR1, NCOR2, VHL | | 42 | negative regulation of apoptotic process | GO:043066 | INF | PIK3CG, RELA, GCG, GCM2, BTC, SERPINE1 | | 43 | cell adhesion | GO:007155 | INF | NCAM1, RELN, KITLG, VWF, VTN, SELP | | 44 | response to hypoxia | GO:001666 | INF | SFTPB, SERPINA1, VEGFA, VCAM1, BMP2, RAF1 | | 45 | gene expression | GO:010467 | INF | NCOR1, NCOR2, PCBP1, RBL1, SERPINE1, VDR | | 46 | induction of apoptosis | GO:006917 | INF | KLF10, PDCD5, BOK, BIK, LCK, BAD | | 47 | protein phosphorylation | GO:006468 | INF | RET, BRAF, MYOD1, , RARA, RAF1 | | 48 | angiogenesis | GO:001525 | INF | PIK3CA, PIK3CG, SETD2, SERPINE1, NAA15, VEGFA | | 49 | innate immune response | GO:045087 | INF | PIK3CG, PIN1, RELA, SFTPD, CLU, BCL2 | | 50 | positive regulation of protein phosphorylation | GO:001934 | INF | PIN1, VEGFA, BMP2, MTOR, P2RY1, AXIN1 |
Molecular functions related to thyroiditis according to GeneDecks: (show all 21)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | enzyme binding | GO:019899 | INF | NCOA1, NCOA6, VHL, RANBP9, RARA, RAD9A | | 2 | ATP binding | GO:005524 | INF | PIK3CB, PIK3CA, PIP5K1C, PIK3C2A, PIK3CG, RFC1 | | 3 | protein heterodimerization activity | GO:046982 | INF | BRAF, VEGFA, VEGFB, BOK, MYC, MYOG | | 4 | sequence-specific DNA binding transcription factor activity | GO:003700 | INF | ZNF197, ZNF71, ZNF131, ZNF138, ZNF135, KLF1 | | 5 | sequence-specific DNA binding | GO:043565 | INF | GCM2, VDR, LMX1B, MYC, RARG, RARA | | 6 | protein binding | GO:005515 | INF | PIK3CB, PIK3CA, PIK3R1, PICALM, PIK3CG, PIN1 | | 7 | identical protein binding | GO:042802 | 24.3 | RELA, PCNA, PCM1, VIM, VCP, RAD51 | | 8 | transcription coactivator activity | GO:003713 | 23.5 | NCOA1, NCOA2, NCOA3, NCOA4, NCOA6, RB1 | | 9 | cytokine activity | GO:005125 | 22.5 | KITLG, NAMPT, VEGFA, BMP1, BMP2, BMP6 | | 10 | growth factor activity | GO:008083 | 22.2 | KITLG, BTC, VGF, VEGFA, VEGFB, VEGFC | | 11 | protein kinase binding | GO:019901 | 21.5 | RELA, KIF11, VIM, RAD9A, USF1, PAK1 | | 12 | chromatin binding | GO:003682 | 19.9 | NCOA1, NCOA2, NCOA3, NCOA6, RELA, LMO2 | | 13 | hormone activity | GO:005179 | 18.9 | RETN, GCG, VIP, UTS2, SCT, LEP | | 14 | steroid hormone receptor activity | GO:003707 | 17.5 | VDR, RARG, RARA, RARB, GPER, HNF4A | | 15 | heparin binding | GO:008201 | 16.9 | LRPAP1, VTN, PCSK6, SELP, SERPINC1, NAV2 | | 16 | thyroid hormone receptor binding | GO:046966 | 15.8 | NCOA3, NCOA6, JMJD1C, GTF2B, MED14, MED16 | | 17 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | GO:004879 | 15.4 | AR, HNF4A, HNF4G, ESR2, ESRRA, ESRRB | | 18 | transcription regulatory region DNA binding | GO:044212 | INF | KLF1, KLF4, NCOR1, RELA, PAX8, PAX2 | | 19 | protein homodimerization activity | GO:042803 | INF | NCOA6, KIT, VWF, SFTPC, VEGFA, VEGFB | | 20 | receptor binding | GO:005102 | INF | REN, GCG, SERPINE1, LPL, VCP, BMP2 | | 21 | transcription factor binding | GO:008134 | INF | RELA, RB1, RBL1, NBN, VHL, MYC |
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