MCID: THY032
MIFTS: 65

Thyroiditis malady

Endocrine diseases, Rare diseases, Immune diseases categories

Summaries for Thyroiditis

About this section


Wikipedia:65 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards based summary: Thyroiditis is related to thyroid cancer and autoimmune thyroiditis. An important gene associated with Thyroiditis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The compounds iodotyrosine and sodium iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Thyroiditis

About this section
Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 29ICD9CM, 57SNOMED-CT, 27ICD10
See all sources

Thyroiditis, Aliases & Descriptions:

Name: Thyroiditis 10 12 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


External Ids:

Disease Ontology10 DOID:7166
ICD9CM29 245.8
ICD1027 E06, E06.9

Related Diseases for Thyroiditis

About this section

Diseases in the Thyroiditis family:

Autoimmune Thyroiditis Subacute Thyroiditis
Acute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1136)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer32.0TPO, TG, TSHR, CALCA
2autoimmune thyroiditis31.9TPO, TG, CALCA
3subacute thyroiditis31.6TPO, TG, TSHR
4hypothyroidism31.5TSHR, TG, TPO
5papillary carcinoma31.5CALCA, TSHR, TG, TPO
6adenoma31.5CTLA4, CALCA, TSHB, TSHR, TG, TPO
7goiter31.4TPO, TG, SERPINA7, TSHR, TSHB, CALCA
8thyroid adenoma31.2TSHR, SERPINA7, TG, TPO
9graves' disease31.2AIRE, TPO, TG, SERPINA7, FASLG, TSHR
10hyperthyroidism31.2TPO, TG, SERPINA7, TSHR, TSHB, CTLA4
11thyrotoxicosis31.2TSHR, SERPINA7, TG, TPO
12thyroid hormone resistance31.1SERPINA7, TG
13congenital hypothyroidism31.1TPO, TG, SERPINA7, TSHR, TSHB
14multiple endocrine neoplasia31.1TG, CALCA
15hepatitis31.1AIRE, SERPINA7, FASLG, CTLA4
16follicular adenoma31.1TPO, TG, TSHR, CALCA
17multinodular goiter31.0CALCA, TSHR, TG, TPO
18endemic goiter31.0TSHR, TG, TPO
19myxedema31.0TPO, TG, TSHR
20nodular goiter30.9TPO, TG, TSHR, ICAM1, CALCA, CTLA4
21struma ovarii30.9TG, TSHR
22hepatitis c30.9TSHR, IFNG, CTLA4
23hashimoto thyroiditis30.8ICAM1, IFNG, IL2RA, CALCA, CTLA4, TSHR
24mucoepidermoid carcinoma30.8CALCA, TG
25thyroid carcinoma, papillary30.8TPO, TG, TSHR
26pendred syndrome30.7TPO, TG
27thyroid carcinoma, follicular30.7CALCA, TSHR, TG
28celiac disease30.6TPO, TG, CTLA4
29hypoparathyroidism30.6CTLA4, CALCA, AIRE
30leukemia30.6FASLG, TSHR, ICAM1, IFNG, IL2RA
31nontoxic goiter30.6TPO, TG, FASLG, TSHR
32arthritis30.5ICAM1, IFNG, CALCA, CTLA4
33hyperthyroxinemia30.5TPO, SERPINA7, TSHR
34hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia30.5TG, SERPINA7, TSHR
35alopecia30.5AIRE
36melanoma30.5FASLG, TSHR, ICAM1, IFNG, CTLA4
37systemic lupus erythematosus30.5TPO, FASLG, TSHR, ICAM1, IFNG, IL2RA
38down syndrome30.5AIRE, TPO, TSHR
39plummer's disease30.4ICAM1, TG, TPO
40autoimmune hepatitis30.4AIRE, TPO, CTLA4
41dermatitis30.4ICAM1, IFNG, CTLA4
42rheumatoid arthritis30.4CTLA4, IL2RA, IFNG, ICAM1, FASLG, HLA-DRB4
43addison's disease30.3AIRE, TPO, TG, CTLA4
44thyroid cancer, anaplastic30.3CALCA, TSHR, TG, TPO
45myasthenia gravis30.3AIRE, IFNG, CTLA4
46psoriasis30.3CTLA4, IL2RA, IFNG, ICAM1
47turner syndrome30.3SERPINA7, TG, TPO
48connective tissue disease30.3ICAM1, IL2RA, CTLA4
49pernicious anemia30.3TPO, TG
50alopecia areata30.2IFNG, ICAM1, AIRE

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Symptoms for Thyroiditis

About this section

Drugs & Therapeutics for Thyroiditis

About this section

Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Genetic Tests for Thyroiditis

About this section

Anatomical Context for Thyroiditis

About this section

MalaCards organs/tissues related to Thyroiditis:

33
Thyroid, Lymph node, Pituitary, Eye, Lung, Testes, T cells, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Thymus, Heart, Kidney, Ovary, Colon, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Skeletal muscle, Salivary gland, Monocytes, Testis, Neutrophil, Spinal cord, Placenta, Fetal thyroid, Prostate, Trachea, Smooth muscle, Cortex, Retina, Adrenal gland, Cervix, Myeloid, Fetal brain, Tongue, Whole blood, Spleen, Cerebellum, Temporal lobe, Cardiac myocytes, Nk cells, Tonsil, Atrioventricular node, Fetal lung, Appendix

Animal Models for Thyroiditis or affiliated genes

About this section

MGI Mouse Phenotypes related to Thyroiditis:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4AIRE, FASLG, IFNG, CALCA, CTLA4
2MP:00020068.4AIRE, FASLG, ICAM1, IFNG, CALCA
3MP:00053918.3IFNG, ICAM1, FASLG, TPO, AIRE
4MP:00053818.1AIRE, FASLG, ICAM1, IFNG, IL2RA, CTLA4
5MP:00053797.7CTLA4, AIRE, TPO, TG, FASLG, TSHR
6MP:00036317.7AIRE, TG, FASLG, TSHR, ICAM1, IFNG
7MP:00053877.5AIRE, TPO, FASLG, TSHR, ICAM1, IFNG
8MP:00053787.4AIRE, TPO, TG, TSHR, ICAM1, IFNG
9MP:00053767.4AIRE, TPO, TG, FASLG, TSHR, ICAM1
10MP:00053977.3AIRE, TPO, TG, FASLG, TSHR, ICAM1
11MP:00107687.1AIRE, TPO, FASLG, TSHR, ICAM1, IFNG

Publications for Thyroiditis

About this section

Articles related to Thyroiditis:

(show top 50)    (show all 13737)
idTitleAuthorsYear
1
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (25754017)
2015
2
Cytomorphology of columnar cell variant of papillary carcinoma thyroid: A case report and review of the literature. (25379049)
2014
3
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
4
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
5
Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients. (23865082)
2013
6
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
7
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
8
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
9
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
10
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
11
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
12
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
13
Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis. (24154902)
2013
14
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
15
Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis. (20738834)
2011
16
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
17
Molecular characterization, gene expression and transcriptional regulation of thyroid hormone receptors in Senegalese sole. (19028494)
2009
18
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
19
Analysis of intracellular proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders]. (17880809)
2007
20
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function. (17458906)
2007
21
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
22
Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae). (16426605)
2006
23
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
24
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. (15727947)
2005
25
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
26
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
27
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene. (15476441)
2004
28
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
29
Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. (11463576)
2001
30
Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (10069663)
1999
31
Protein-protein interaction domains and the heterodimerization of thyroid hormone receptor variant alpha2 with retinoid X receptors. (9773977)
1998
32
Neoexpression of the epithelial adhesion complex antigens in thyroid tumours is associated with proliferation and squamous differentiation markers. (9602711)
1998
33
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissue. (9360536)
1997
34
Differential effects of 2'-deoxyguanosine on peripheral blood mononuclear cell proliferation in healthy donors and Hashimoto's thyroiditis patients. (8980658)
1996
35
Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements. (7775449)
1995
36
The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. (7731681)
1995
37
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
38
Multidrug resistance gene and P-glycoprotein expression in anaplastic carcinoma of the thyroid. (7812988)
1994
39
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
40
Study of the localization and the concentration of superoxide dismutase in various thyroid disorders]. (8232185)
1993
41
Homology model of thyroxine binding globulin and elucidation of the thyroid hormone binding site. (1631046)
1992
42
Monoclonal gammopathy as a clue to the presence of thyroid lymphoma associated with auto-immune thyroiditis. (1445050)
1992
43
Medullary cancer of the thyroid and multiple endocrine neoplastic syndromes]. (1351314)
1992
44
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin. (1679761)
1991
45
Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase. (1706451)
1991
46
Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (1850510)
1991
47
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. (2153155)
1990
48
Hashimoto's thyroiditis as a risk factor of thyroid lymphoma. (2220394)
1990
49
THYROID CRISIS. (14167406)
1964
50
Thyroid crisis. (14829802)
1951

Variations for Thyroiditis

About this section

Expression for genes affiliated with Thyroiditis

About this section

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

About this section

Pathways related to Thyroiditis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.6TPO, TG, TSHR
39.6CALCA, TSHB, TSHR
49.5IFNG, ICAM1
59.5IFNG, IL2RA
69.5IFNG, IL2RA
79.5IL2RA, IFNG
8
Show member pathways
9.3TPO, TG, TSHR, TSHB
99.2CALCA, IFNG, FASLG
109.2HLA-DRB4, ICAM1, CTLA4
11
Show member pathways
Type III interferon signaling38
9.2IL2RA, IFNG, TPO
129.2IFNG, ICAM1, FASLG
13
Show member pathways
Immune response CD16 signaling in NK cells60
9.2IFNG, ICAM1, FASLG
149.2FASLG, ICAM1, IFNG
15
Show member pathways
9.2HLA-DRB4, IL2RA, CTLA4
16
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1IL2RA, IFNG, FASLG
17
Show member pathways
9.1IL2RA, IFNG, FASLG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.1FASLG, IFNG, IL2RA
199.1HLA-DRB4, TPO, IL2RA
209.0IL2RA, ICAM1, HLA-DRB4
218.9HLA-DRB4, ICAM1, IFNG
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.9CTLA4, IL2RA, IFNG, FASLG
23
Show member pathways
8.8IL2RA, IFNG, FASLG, TPO
248.7HLA-DRB4, ICAM1, IFNG, CTLA4
25
Show member pathways
8.7AIRE, HLA-DRB4, ICAM1, CTLA4
26
Show member pathways
8.5HLA-DRB4, ICAM1, IFNG, IL2RA
27
Show member pathways
8.1HLA-DRB4, FASLG, ICAM1, IFNG, IL2RA
28
Show member pathways
6.7CTLA4, HLA-DRB4, TPO, TG, FASLG, TSHR

Compounds for genes affiliated with Thyroiditis

About this section

Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2611.1TPO, TG
2sodium iodide4510.0TG, TSHR, TPO
3propylthiouracil45 3 1311.9TG, TPO, TSHR
4diiodotyrosine459.9TG, TPO
5chromium459.8FASLG, TG, TPO
6carbimazole45 1310.8IL2RA, TSHR, TPO
7con a459.5IL2RA, IFNG, CTLA4
8natalizumab45 1310.4IL2RA, IFNG, ICAM1
9nitrate459.4TPO, FASLG, IL2RA
10parthenolide45 310.4IFNG, ICAM1, FASLG
11amiodarone45 51 30 1312.4TG, SERPINA7, TPO
12okt3459.3IFNG, ICAM1, IL2RA
13hydrocortisone45 3 61 1312.3TG, TPO, IFNG, CALCA
14mycophenolate mofetil45 51 1311.3CTLA4, IL2RA, IFNG
15thalidomide45 51 61 1312.2IFNG, IL2RA, FASLG, CTLA4
16ivig459.2FASLG, TG, IFNG, IL2RA
17prednisolone45 30 1311.2IFNG, TG, IL2RA, TSHR
18acetylcholine45 51 30 26 1313.2TG, TPO, CTLA4, IL2RA, CALCA
19125i459.2TSHR, TG, TPO, SERPINA7
20iodide45 2610.2TSHR, TG, TPO, SERPINA7
21tacrolimus45 51 1311.0IFNG, FASLG, IL2RA, CTLA4
22ascorbic acid45 2610.0TPO, FASLG, TG, ICAM1, IL2RA
23guanine45 26 1311.0TG, ICAM1, CALCA, TSHR
24calcitriol45 61 26 1312.0CALCA, IL2RA, IFNG, TG
25ionomycin459.0CTLA4, IL2RA, IFNG, FASLG, TSHR
26iodine45 2610.0CTLA4, TSHR, SERPINA7, TG, TPO
27agarose459.0SERPINA7, FASLG, TPO, TSHR
28triiodothyronine458.9TSHB, TSHR, TG, TPO, SERPINA7
29rantes458.9CTLA4, FASLG, ICAM1, IL2RA, IFNG
30ribonucleic acid458.9TSHB, TPO, TSHR, SERPINA7, TG
31acth458.8TSHB, CALCA, TSHR, SERPINA7, TPO
32adenylate458.8FASLG, TSHR, IL2RA, CALCA, TG, TPO
33polysaccharide458.8TSHR, ICAM1, FASLG, TG, TPO, IL2RA
34pge2458.6IL2RA, ICAM1, CALCA, IFNG, FASLG
35thyroxine45 269.6TSHB, TSHR, SERPINA7, TG, CALCA, TPO
36glutamate458.6FASLG, TG, TSHR, TPO, IL2RA, CALCA
37genistein45 30 61 3 26 1313.6IL2RA, TPO, TG, FASLG, ICAM1, IFNG
38thymidine45 269.5TSHB, TSHR, CTLA4, IL2RA, TG, FASLG
39creatinine458.4IL2RA, CALCA, SERPINA7, TPO, TG
40retinoic acid45 269.4TSHR, IFNG, TG, ICAM1, TSHB, TPO
41cysteine458.4CTLA4, FASLG, TPO, TG, TSHR, IFNG
42methimazole45 3 1310.3TPO, TG, SERPINA7, TSHR, IL2RA, ICAM1
43aspartate458.3IL2RA, TSHR, FASLG, SERPINA7, TG, TPO
44cyclosporin a45 30 6110.3CTLA4, IFNG, ICAM1, FASLG, CALCA, TG
45cycloheximide458.3TG, FASLG, IFNG, ICAM1, TPO
46testosterone45 61 26 1311.2TPO, SERPINA7, FASLG, CALCA, IL2RA, TG
47vegf458.2FASLG, TSHR, ICAM1, IFNG, IL2RA, CALCA
48arginine458.1IL2RA, TSHR, SERPINA7, TG, TPO, IFNG
49estrogen457.8CALCA, CTLA4, TSHR, IL2RA, TSHB, FASLG
50tyrosine457.2TG, TPO, AIRE, SERPINA7, TSHR, FASLG

GO Terms for genes affiliated with Thyroiditis

About this section

Cellular components related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.9HLA-DRB4, TPO, FASLG, TSHR, ICAM1, CTLA4
2extracellular regionGO:00055767.9CALCA, IFNG, TSHB, FASLG, SERPINA7, TG
3external side of plasma membraneGO:00098977.9CTLA4, IL2RA, IFNG, ICAM1, FASLG, HLA-DRB4
4extracellular spaceGO:00056157.3TPO, TG, SERPINA7, FASLG, ICAM1, IFNG

Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1TPO, TG
2thyroid hormone generationGO:000659010.0TG, TPO
3negative regulation of immune responseGO:005077710.0IL2RA, CTLA4
4leukocyte cell-cell adhesionGO:00071599.7ICAM1, CALCA
5extrinsic apoptotic signaling pathwayGO:00971919.6IFNG, FASLG
6inflammatory response to antigenic stimulusGO:00024379.5IL2RA, HLA-DRB4
7response to vitamin AGO:00331899.5TSHB, SERPINA7
8positive regulation of nitric oxide biosynthetic processGO:00454299.4IFNG, ICAM1
9cell-cell signalingGO:00072679.4FASLG, TSHR, TSHB, CALCA
10negative regulation of T cell proliferationGO:00421309.4HLA-DRB4, IL2RA, CTLA4
11interferon-gamma-mediated signaling pathwayGO:00603339.1IFNG, ICAM1, HLA-DRB4
12cytokine-mediated signaling pathwayGO:00192218.6IFNG, ICAM1, HLA-DRB4
13immune responseGO:00069558.5CTLA4, IL2RA, FASLG, HLA-DRB4, AIRE

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6CALCA, TSHB, TG

Products for genes affiliated with Thyroiditis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Thyroiditis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet