MCID: THY032
MIFTS: 67

Thyroiditis malady

Endocrine diseases category

Summaries for Thyroiditis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards: Thyroiditis is related to thyroid cancer and papillary carcinoma. An important gene associated with Thyroiditis is THRB (thyroid hormone receptor, beta), and among its related pathways are Insulin secretion and Allograft rejection. The compounds tyrosine and estrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Thyroiditis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

thyroiditis 8 10 44 60


External Ids:

Disease Ontology8 DOID:7166
ICD9CM27 245.8
ICD1025 E06, E06.9

Related Diseases for Thyroiditis

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17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis
thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1069)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer31.9CCDC6, NKX2-1, TPO, TSHR, THRB, DUOX1
2papillary carcinoma31.9NKX2-1, DUOX1, TSHR, TPO
3papillary thyroid carcinoma31.9TSHR, CCDC6, TPO
4autoimmune thyroiditis31.8TSHR, TPO, LMOD1
5follicular thyroid carcinoma31.5THRB, TSHR
6subacute thyroiditis31.4TSHR, TPO
7adenoma31.4CGA, NKX2-1, PKM, DUOX1, DUOX2, LMOD1
8goiter31.4TPO, TSHR, TSHB, THRB, LMOD1, NKX2-1
9hypothyroidism31.4TPO, NKX2-1, TSHR
10graves' disease31.4CGA, TPO, TSHR, THRB, LMOD1, FOXE1
11hyperthyroidism31.2TPO, TSHR, CGA, LMOD1, TSHB, THRB
12thyrotoxicosis31.1THRB, TSHR, TPO
13congenital hypothyroidism31.1DUOX1, FOXE1, DUOX2, NKX2-1, TSHR, TPO
14follicular adenoma31.0TPO, NKX2-1, LMOD1, TSHR
15multinodular goiter30.9TPO, TSHR
16endemic goiter30.9TPO, TSHR
17nodular goiter30.9TSHR, TPO
18myxedema30.8TSHR, TPO
19struma ovarii30.7TSHR, NKX2-1
20nontoxic goiter30.6TSHR, TPO
21breast cancer30.6THRB, MED1, LMOD1, NCOR2
22pendred syndrome30.5TPO, DUOX2
23hyperthyroxinemia30.4TPO, TSHR
24lung cancer30.4NKX2-1
25thyroid cancer, anaplastic30.3TSHR, NKX2-1, TPO
26thyroid agenesis30.2TSHR, NKX2-1, FOXE1
27toxic diffuse goiter29.6TSHR, TPO
28thyrotropin deficiency, isolated29.4TPO, TSHB
29thyroid medullary carcinoma11.1
30acute thyroiditis10.9
31thyroid lymphoma10.9
32suppurative thyroiditis10.8
33familial medullary thyroid carcinoma10.7
34eye disease10.7
35hepatitis10.7
36adenocarcinoma10.6
37cervicitis10.6
38thyroid crisis10.6
39thyroid hormone resistance syndrome10.5
40diabetes mellitus10.5
41hepatitis c10.5
42papillary adenoma10.5
43lymph node cancer10.5
44papillary adenocarcinoma10.5
45parathyroid adenoma10.5
46thyroid gland disease10.4
47hyperparathyroidism10.4
48obesity10.4
49mucoepidermoid thyroid carcinoma10.4
50type 1 diabetes mellitus10.4

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Clinical Features for Thyroiditis

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Drugs & Therapeutics for Thyroiditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Search CenterWatch for Thyroiditis

Genetic Tests for Thyroiditis

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Anatomical Context for Thyroiditis

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32MalaCards
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MalaCards organs/tissues related to Thyroiditis:

32
Thyroid, Lymph node, Pituitary, Eye, Testes, Lung, T cells, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Heart, Kidney, Ovary, Colon, Thymus, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Monocytes, Skeletal muscle, Testis, Salivary gland, Fetal thyroid, Placenta, Prostate, Spinal cord, Trachea, Smooth muscle, Cervix, Tongue, Adrenal gland, Fetal brain, Retina, Myeloid, Cortex, Whole blood, Spleen, Temporal lobe, Cardiac myocytes, Cerebellum, Nk cells, Appendix, Fetal lung, Tonsil, Atrioventricular node

Animal Models for Thyroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076813.2NCOR2, NKX2-1, MED1, FOXE1, PKM, TRIP13
2MP:000537613.1FOXE1, MED1, CGA, NKX2-1, NCOR2, DUOX2
3MP:000537912.7TPO, FOXE1, MED1, CGA, NKX2-1, DUOX2
4MP:000537812.7NCOR2, NKX2-1, CGA, MED1, DUOX2, TRIP13

Publications for Thyroiditis

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50PubMed
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Articles related to Thyroiditis:

(show top 50)    (show all 13308)
idTitleAuthorsYear
1
Fine needle aspiration of a lingual thyroid with Hashimoto's thyroiditis. (22448979)
2013
2
Localization of CaSR antagonists in CaSR-expressing medullary thyroid cancer. (24030941)
2013
3
Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone. (23671315)
2013
4
Solitary extramedullary plasmacytoma of the thyroid gland. (23094168)
2012
5
Amyloid accumulation in the toxic nodule of the thyroid gland in a patient with end stage renal failure. (23133762)
2012
6
A case of Riedel's thyroiditis. (22563540)
2012
7
Follicular thyroid carcinoma presenting as massive skull metastasis: a rare case report and literature review. (23741589)
2012
8
Preoperative thyroid ultrasound is indicated in patients undergoing parathyroidectomy for primary hyperparathyroidism. (22211139)
2012
9
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. (20526288)
2010
10
Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study. (19926842)
2010
11
Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor. (20004952)
2010
12
Clinically unsuspected thyroid involvement in cysticercosis: a case report. (21053555)
2010
13
Diagnostic utility of galectin-3 in thyroid cancer. (20363921)
2010
14
Caspase-3 activity in papillary thyroid carcinomas. (21270757)
2010
15
Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. (19064983)
2009
16
Increased fetal abortion rate in autoimmune thyroid disease is related to circulating TPO autoantibodies in an autoimmune thyroiditis animal model. (18774556)
2009
17
Clinical implication of F-18 FDG PET/CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin. (18207685)
2009
18
BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells. (18458053)
2008
19
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. (17596674)
2007
20
Integrating basic research on thyroid hormone action into screening and testing programs for thyroid disruptors. (17364703)
2007
21
Comparative genomic hybridization, BRAF, RAS, RET, and oligo-array analysis in aneuploid papillary thyroid carcinomas. (17786355)
2007
22
Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. (17465866)
2007
23
Comparison of CD15, galectin-3 and HBME-1 expression in follicular thyroid neoplasms]. (17006830)
2006
24
Clinical perspectives of thyroid eye disease. (17145242)
2006
25
American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. (16596732)
2006
26
Takayasu's arteritis and chronic autoimmune thyroiditis in a patient with type 1 diabetes mellitus. (15818512)
2005
27
Thyroid neoplasia, autoimmune thyroiditis, and hypothyroidism in persons exposed to iodine 131 from the hanford nuclear site. (15572718)
2004
28
Recombinant human TSH changes the multidisciplinary approach to patients with differentiated thyroid carcinoma. Two-year experience. (14605601)
2003
29
Early malignant progression of hereditary medullary thyroid cancer. (14561794)
2003
30
KAI1 expression in thyroid neoplasms: its linkage with clinicopathologic features in papillary carcinoma. (12747469)
2003
31
Increased expression of endothelin-1 and its mitogenic receptor ETA in human papillary thyroid carcinoma. (12919159)
2003
32
Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile? (12229955)
2002
33
Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin. (12030609)
2002
34
Improved prediction of calcitonin normalization in medullary thyroid carcinoma patients by quantitative lymph node analysis. (10760769)
2000
35
Short-chain fatty acids and thyroid hormone interact in regulating enterocyte gene transcription. (10455897)
1999
36
Reduced expression of interleukin 6 in undifferentiated thyroid carcinoma: in vitro and in vivo studies. (9516926)
1998
37
Abnormal transcripts of FHIT gene in thyroid cancer. (9458330)
1998
38
ret/PTC-1, -2, and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? (8784097)
1996
39
Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas. (8912526)
1996
40
Importance of the most proximal GC box for activity of the promoter of human thyroid hormone receptor beta 1. (8544837)
1995
41
RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma. (7575334)
1995
42
Aberrations of growth factor control in metastatic follicular thyroid cancer in vitro. (8039305)
1994
43
Thyroid function and serum IGF-1 in children before and after liver transplantation. (7735373)
1994
44
A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone. (8175986)
1994
45
Riedel thyroiditis: US, CT, and MR evaluation. (8454764)
1993
46
The c-erb-A gene encodes a thyroid hormone receptor. (2879243)
1986
47
Recurrent suppurative thyroiditis due to pyriform fossa--thyroid fistula. (6864098)
1983
48
The successful treatment of myxedema and coronary artery disease in patients intolerant of thyroid hormone. (4548113)
1974
49
Idiopathic juvenile myxedema and myasthenia gravis. A case with circulating thyroid and skeletal muscle antibodies. (6060416)
1967
50
The malignant thyroid adenoma; treatment and results. (13843825)
1960

Genetic Variations for Thyroiditis

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Expression for genes affiliated with Thyroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Thyroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CGA, DUOX2, TSHB, TSHR
2
Hide members
11.2TPO, TSHR, TSHB
3
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11.0TSHR, TSHB
411.0NCOR2, MED1

Compounds for genes affiliated with Thyroiditis

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB
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Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1tyrosine4413.1CCDC6, BRD8, NKX2-1, NCOR2, PKM, LMOD1
2estrogen4412.8MED1, CGA, NKX2-1, NCOR2, LMOD1, THRB
3iodide44 2413.6TPO, FOXE1, NKX2-1, DUOX1, DUOX2, LMOD1
4triiodothyronine4412.6CGA, NCOR2, LMOD1, THRB, TSHB, TSHR
5retinoic acid44 2413.5MED1, NKX2-1, NCOR2, THRB, TSHB, TSHR
6thyroxine44 2413.3CGA, LMOD1, THRB, TSHB, TSHR, TPO
7ribonucleic acid4412.3CGA, NKX2-1, THRB, TSHB, TSHR, TPO
8steroid4412.3MED1, CGA, NKX2-1, NCOR2, THRB, TPO
9alanine4412.2FOXE1, MED1, CGA, PKM, THRB, TSHR
10sodium44 2413.0FOXE1, NKX2-1, DUOX2, TSHR, TPO
11progesterone44 59 28 11 2415.9CGA, NKX2-1, NCOR2, THRB, TSHR
12sodium iodide4411.8NKX2-1, DUOX2, TSHR, TPO
13iodine44 2412.8DUOX2, LMOD1, TSHR, TPO
14retinoid4411.7MED1, NCOR2, THRB, TSHB
15vitamin d4411.6MED1, CGA, NCOR2, THRB
16propylthiouracil44 2 1113.6LMOD1, TSHR, TPO
17amiodarone44 49 28 1114.5TPO, THRB, LMOD1
18125i4411.5LMOD1, TSHR, TPO
19estradiol44 11 2413.4MED1, CGA, NCOR2, TSHR
20Dextrothyroxine1111.2TPO, THRB
21forskolin44 49 1113.2TPO, TSHR, NKX2-1, CGA
22perchlorate4411.2TPO, DUOX2
23carbimazole44 1112.2TPO, TSHR
24Liothyronine11 2412.0TPO, THRB
25amino acid4411.0TPO, TSHR
26maltose44 1112.0TPO, TSHR

GO Terms for genes affiliated with Thyroiditis

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16Gene Ontology
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Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659012.2TPO, DUOX2, DUOX1, CGA, MED1, FOXE1
2negative regulation of transcription from RNA polymerase II promoterGO:00012211.7THRB, NCOR2, NKX2-1, MED1, FOXE1
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.4THRB, HMGN3, NKX2-1, CGA, MED1
4hormone biosynthetic processGO:04244611.4DUOX1, DUOX2, TPO
5thyroid gland developmentGO:03087811.4NKX2-1, CGA, FOXE1
6hydrogen peroxide catabolic processGO:04274411.3TPO, DUOX2, DUOX1
7cuticle developmentGO:04233511.0DUOX1, DUOX2
8embryonic hemopoiesisGO:03516211.0TPO, MED1
9peptide hormone processingGO:01648610.9CGA, TSHB

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor bindingGO:04696611.5ZNHIT3, HMGN3, TRIP12, MED1
2peroxidase activityGO:00460111.2TPO, DUOX2, DUOX1
3heme bindingGO:02003711.2TPO, DUOX2, DUOX1
4NAD(P)H oxidase activityGO:01617410.9DUOX1, DUOX2
5thyroid hormone receptor activityGO:00488710.7THRB, BRD8

Products for genes affiliated with Thyroiditis

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  • Antibodies
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  • Antibodies

Sources for Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet