MCID: THY032
MIFTS: 66

Thyroiditis malady

Endocrine diseases, Rare diseases, Immune diseases categories

Summaries for Thyroiditis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

MalaCards: Thyroiditis is related to thyroid cancer and papillary thyroid carcinoma. An important gene associated with Thyroiditis is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Hormone ligand-binding receptors and Thyroxine (Thyroid Hormone) Production. The compounds iodotyrosine and sodium iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and pituitary, and related mouse phenotypes are respiratory system and tumorigenesis.

Aliases & Classifications for Thyroiditis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


Aliases & Descriptions:

thyroiditis 9 11 46 63


External Ids:

Disease Ontology9 DOID:7166
ICD9CM28 245.8
ICD1026 E06, E06.9

Related Diseases for Thyroiditis

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18GeneCards, 19GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Subacute Thyroiditis Acute Thyroiditis
thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1153)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer32.0TPO, TG, TSHR, CALCA
2papillary thyroid carcinoma31.9TPO, TG, TSHR
3autoimmune thyroiditis31.9TPO, TG, CALCA
4subacute thyroiditis31.6TPO, TG, TSHR
5hypothyroidism31.6TSHR, TG, TPO
6papillary carcinoma31.5CALCA, TSHR, TG, TPO
7follicular thyroid carcinoma31.5CALCA, TSHR, TG
8adenoma31.4CTLA4, CALCA, TSHB, TSHR, TG, TPO
9goiter31.3TPO, TG, SERPINA7, TSHR, TSHB, CALCA
10thyroid adenoma31.2TSHR, SERPINA7, TG, TPO
11hyperthyroidism31.1TPO, TG, SERPINA7, TSHR, TSHB, CTLA4
12thyrotoxicosis31.1TSHR, SERPINA7, TG, TPO
13multiple endocrine neoplasia31.1TG, CALCA
14endemic goiter31.0TSHR, TG, TPO
15follicular adenoma31.0TPO, TG, TSHR, CALCA
16congenital hypothyroidism31.0TPO, TG, SERPINA7, TSHR, TSHB
17multinodular goiter31.0CALCA, TSHR, TG, TPO
18graves' disease31.0AIRE, TPO, TG, SERPINA7, FASLG, TSHR
19myxedema31.0TPO, TG, TSHR
20hepatitis31.0AIRE, SERPINA7, FASLG, CTLA4
21struma ovarii30.9TG, TSHR
22hepatitis c30.9TSHR, IFNG, CTLA4
23diabetes mellitus30.9AIRE, ICAM1, CALCA, CTLA4
24nodular goiter30.8TPO, TG, TSHR, ICAM1, CALCA, CTLA4
25thyroid hormone resistance syndrome30.8SERPINA7, TG
26mucoepidermoid carcinoma30.8CALCA, TG
27pendred syndrome30.7TPO, TG
28type 1 diabetes mellitus30.6TPO, FASLG, IFNG, CTLA4
29vitiligo30.6AIRE, TPO, CTLA4
30celiac disease30.6TPO, TG, CTLA4
31hypoparathyroidism30.6CTLA4, CALCA, AIRE
32thyroid agenesis30.6TG, SERPINA7, TSHR
33nontoxic goiter30.6TPO, TG, FASLG, TSHR
34hyperthyroxinemia30.5TPO, SERPINA7, TSHR
35leukemia30.5FASLG, TSHR, ICAM1, IFNG, IL2RA
36alopecia30.5AIRE
37arthritis30.5ICAM1, IFNG, CALCA, CTLA4
38down syndrome30.5AIRE, TPO, TSHR
39plummer's disease30.4ICAM1, TG, TPO
40melanoma30.4FASLG, TSHR, ICAM1, IFNG, CTLA4
41thyroid cancer, anaplastic30.4CALCA, TSHR, TG, TPO
42autoimmune hepatitis30.3AIRE, TPO, CTLA4
43addison's disease30.3AIRE, TPO, TG, CTLA4
44systemic lupus erythematosus30.3TPO, FASLG, TSHR, ICAM1, IFNG, IL2RA
45dermatitis30.3ICAM1, IFNG, CTLA4
46pernicious anemia30.3TPO, TG
47sarcoidosis30.3ICAM1, IFNG, IL2RA
48myasthenia gravis30.3AIRE, IFNG, CTLA4
49connective tissue disease30.3ICAM1, IL2RA, CTLA4
50psoriasis30.3CTLA4, IL2RA, IFNG, ICAM1

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to thyroiditis

Symptoms for Thyroiditis

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Drugs & Therapeutics for Thyroiditis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Thyroiditis

Search NIH Clinical Center for Thyroiditis

Search CenterWatch for Thyroiditis

Genetic Tests for Thyroiditis

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Anatomical Context for Thyroiditis

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34MalaCards
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MalaCards organs/tissues related to Thyroiditis:

34
Thyroid, Lymph node, Pituitary, Eye, Testes, Lung, T cells, Bone, Brain, Breast, Endothelial, Liver, B cells, Skin, Heart, Kidney, Ovary, Colon, Thymus, Hypothalamus, Adipocyte, Pancreas, Bone marrow, Monocytes, Skeletal muscle, Salivary gland, Testis, Fetal thyroid, Spinal cord, Placenta, Prostate, Trachea, Smooth muscle, Cervix, Tongue, Adrenal gland, Fetal brain, Retina, Myeloid, Cortex, Whole blood, Spleen, Temporal lobe, Cardiac myocytes, Cerebellum, Nk cells, Appendix, Fetal lung, Tonsil, Atrioventricular node

Animal Models for Thyroiditis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thyroiditis:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4AIRE, FASLG, IFNG, CALCA, CTLA4
2MP:00020068.4AIRE, FASLG, ICAM1, IFNG, CALCA
3MP:00053918.3IFNG, ICAM1, FASLG, TPO, AIRE
4MP:00053818.1AIRE, FASLG, ICAM1, IFNG, IL2RA, CTLA4
5MP:00053797.7CTLA4, AIRE, TPO, TG, FASLG, TSHR
6MP:00036317.7AIRE, TG, FASLG, TSHR, ICAM1, IFNG
7MP:00053877.5AIRE, TPO, FASLG, TSHR, ICAM1, IFNG
8MP:00053787.4AIRE, TPO, TG, TSHR, ICAM1, IFNG
9MP:00053767.4AIRE, TPO, TG, FASLG, TSHR, ICAM1
10MP:00053977.3AIRE, TPO, TG, FASLG, TSHR, ICAM1
11MP:00107687.1AIRE, TPO, FASLG, TSHR, ICAM1, IFNG

Publications for Thyroiditis

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53PubMed
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Articles related to Thyroiditis:

(show top 50)    (show all 13163)
idTitleAuthorsYear
1
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
2
Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti-TPO antibodies in 2267 patients. (23865082)
2013
3
Papillary carcinoma in a thyroglossal duct cyst with concurrent thyroid micro-carcinoma and neck nodal metastases. (24426727)
2013
4
Commentary on: Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. (23987661)
2013
5
Subacute thyroiditis (de Quervain's) due to influenza A: presenting as fever of unknown origin (FUO). (22819125)
2013
6
Evolving approaches to patients with advanced differentiated thyroid cancer. (23575762)
2013
7
Expression and clinical significance of STIP1 in papillary thyroid carcinoma. (24163084)
2013
8
Tumor size measured by preoperative ultrasonography and postoperative pathologic examination in papillary thyroid carcinoma: relative differences according to size, calcification and coexisting thyroiditis. (23880922)
2013
9
Establishing a familial basis for papillary thyroid carcinoma using the Utah Population Database. (24092278)
2013
10
Correlation between sonography and antibody activity in patients with Hashimoto thyroiditis. (24154902)
2013
11
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. (21606412)
2011
12
Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis. (20738834)
2011
13
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer. (21803186)
2011
14
Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma. (19088163)
2009
15
Molecular characterization, gene expression and transcriptional regulation of thyroid hormone receptors in Senegalese sole. (19028494)
2009
16
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
17
Analysis of intracellular proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins expression in thyrocytes from young patients with immune and non-immune thyroid disorders]. (17880809)
2007
18
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function. (17458906)
2007
19
Management of menopausal symptoms associated with papillary carcinoma of thyroid. (17000524)
2006
20
Unique regulation of thyroid hormone metabolism during fasting in the house musk shrew (Suncus murinus, Insectivora: Soricidae). (16426605)
2006
21
Antigenic determinants to GAD autoantibodies in patients with type 1 diabetes with and without autoimmune thyroid disease. (17130557)
2006
22
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
23
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. (15727947)
2005
24
Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones. (16131812)
2005
25
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (15767343)
2005
26
A thyroid nodule revealing a paraganglioma in a patient with a new germline mutation in the succinate dehydrogenase B gene. (15476441)
2004
27
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
28
Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. (11463576)
2001
29
Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures. (10069663)
1999
30
Protein-protein interaction domains and the heterodimerization of thyroid hormone receptor variant alpha2 with retinoid X receptors. (9773977)
1998
31
Neoexpression of the epithelial adhesion complex antigens in thyroid tumours is associated with proliferation and squamous differentiation markers. (9602711)
1998
32
Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: analysis of protein expression in Graves' thyroid tissue. (9360536)
1997
33
Differential effects of 2'-deoxyguanosine on peripheral blood mononuclear cell proliferation in healthy donors and Hashimoto's thyroiditis patients. (8980658)
1996
34
Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements. (7775449)
1995
35
The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. (7731681)
1995
36
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
37
Multidrug resistance gene and P-glycoprotein expression in anaplastic carcinoma of the thyroid. (7812988)
1994
38
Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone. (7913092)
1994
39
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
40
Study of the localization and the concentration of superoxide dismutase in various thyroid disorders]. (8232185)
1993
41
Homology model of thyroxine binding globulin and elucidation of the thyroid hormone binding site. (1631046)
1992
42
Monoclonal gammopathy as a clue to the presence of thyroid lymphoma associated with auto-immune thyroiditis. (1445050)
1992
43
Medullary cancer of the thyroid and multiple endocrine neoplastic syndromes]. (1351314)
1992
44
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin. (1679761)
1991
45
Cross-reactivity between antibodies to thyroid microsomal antigens and myeloperoxidase. (1706451)
1991
46
Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (1850510)
1991
47
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. (2153155)
1990
48
Hashimoto's thyroiditis as a risk factor of thyroid lymphoma. (2220394)
1990
49
THYROID CRISIS. (14167406)
1964
50
Thyroid crisis. (14829802)
1951

Variations for Thyroiditis

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Expression for genes affiliated with Thyroiditis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for genes affiliated with Thyroiditis

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN, 55R&D Systems
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Pathways related to Thyroiditis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TSHB, TSHR
29.6TPO, TG, TSHR
39.6CALCA, TSHB, TSHR
49.5IFNG, ICAM1
59.5IFNG, IL2RA
69.5IFNG, IL2RA
79.5IL2RA, IFNG
8
Show member pathways
9.3TPO, TG, TSHR, TSHB
99.2CALCA, IFNG, FASLG
109.2HLA-DRB4, ICAM1, CTLA4
11
Show member pathways
Type III interferon signaling39
9.2IL2RA, IFNG, TPO
129.2IFNG, ICAM1, FASLG
13
Show member pathways
Immune response CD16 signaling in NK cells61
9.2IFNG, ICAM1, FASLG
149.2FASLG, ICAM1, IFNG
15
Show member pathways
9.2HLA-DRB4, IL2RA, CTLA4
16
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.1IL2RA, IFNG, FASLG
17
Show member pathways
9.1IL2RA, IFNG, FASLG
18
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.1FASLG, IFNG, IL2RA
199.1HLA-DRB4, TPO, IL2RA
209.0IL2RA, ICAM1, HLA-DRB4
218.9HLA-DRB4, ICAM1, IFNG
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.9CTLA4, IL2RA, IFNG, FASLG
23
Show member pathways
8.8IL2RA, IFNG, FASLG, TPO
248.7HLA-DRB4, ICAM1, IFNG, CTLA4
25
Show member pathways
8.7AIRE, HLA-DRB4, ICAM1, CTLA4
26
Show member pathways
8.5HLA-DRB4, ICAM1, IFNG, IL2RA
27
Show member pathways
8.1HLA-DRB4, FASLG, ICAM1, IFNG, IL2RA
28
Show member pathways
6.7CTLA4, HLA-DRB4, TPO, TG, FASLG, TSHR

Compounds for genes affiliated with Thyroiditis

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Sources:
46Novoseek, 25HMDB, 3BitterDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Thyroiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1iodotyrosine46 2511.1TG, TPO
2sodium iodide4610.0TPO, TG, TSHR
3propylthiouracil46 3 1211.9TG, TSHR, TPO
4diiodotyrosine469.9TPO, TG
5chromium469.8TG, FASLG, TPO
6carbimazole46 1210.8IL2RA, TSHR, TPO
7con a469.5IFNG, IL2RA, CTLA4
8natalizumab46 1210.4IFNG, IL2RA, ICAM1
9nitrate469.4TPO, FASLG, IL2RA
10parthenolide46 310.4ICAM1, IFNG, FASLG
11amiodarone46 52 30 1212.4SERPINA7, TG, TPO
12okt3469.3IL2RA, ICAM1, IFNG
13hydrocortisone46 3 62 1212.3CALCA, IFNG, TG, TPO
14il 10469.3CTLA4, IL2RA, IFNG
15thalidomide46 52 62 1212.2CTLA4, IL2RA, FASLG, IFNG
16ivig469.2TG, FASLG, IFNG, IL2RA
17prednisolone46 30 1211.2TG, TSHR, IL2RA, IFNG
18acetylcholine46 52 30 25 1213.2CTLA4, TPO, CALCA, IL2RA, TG
19125i469.2TSHR, TG, TPO, SERPINA7
20iodide46 2510.2TSHR, TG, TPO, SERPINA7
21tacrolimus46 52 1211.0IL2RA, IFNG, CTLA4, FASLG
22ascorbic acid46 2510.0TPO, IL2RA, ICAM1, FASLG, TG
23guanine46 25 1211.0TG, ICAM1, TSHR, CALCA
24calcitriol46 62 25 1212.0CALCA, IL2RA, IFNG, TG
25ionomycin469.0CTLA4, IL2RA, IFNG, FASLG, TSHR
26iodine46 2510.0CTLA4, TSHR, SERPINA7, TG, TPO
27agarose469.0TPO, SERPINA7, FASLG, TSHR
28triiodothyronine468.9TSHB, TSHR, TG, TPO, SERPINA7
29rantes468.9IFNG, CTLA4, ICAM1, FASLG, IL2RA
30ribonucleic acid468.9TPO, TSHB, TSHR, SERPINA7, TG
31acth468.8CALCA, TSHR, SERPINA7, TPO, TSHB
32adenylate468.8TSHR, FASLG, IL2RA, TPO, TG, CALCA
33polysaccharide468.8TSHR, ICAM1, FASLG, TG, TPO, IL2RA
34pge2468.6IFNG, ICAM1, FASLG, IL2RA, CALCA
35thyroxine46 259.6TSHB, TSHR, SERPINA7, TG, CALCA, TPO
36glutamate468.6FASLG, TPO, CTLA4, CALCA, IL2RA, TSHR
37genistein46 30 62 3 25 1213.6IL2RA, TPO, TG, FASLG, ICAM1, IFNG
38thymidine46 259.5TSHB, TSHR, CTLA4, IL2RA, TG, FASLG
39creatinine468.4CALCA, IL2RA, TG, TPO, SERPINA7
40retinoic acid46 259.4IFNG, TSHR, ICAM1, TPO, TSHB, TG
41cysteine468.4CTLA4, IL2RA, IFNG, TSHR, TG, FASLG
42methimazole46 3 1210.3TPO, TG, SERPINA7, TSHR, IL2RA, ICAM1
43aspartate468.3TG, TPO, SERPINA7, FASLG, TSHR, IL2RA
44cyclosporin a46 30 6210.3CTLA4, IFNG, ICAM1, FASLG, CALCA, TG
45cycloheximide468.3ICAM1, FASLG, IFNG, TG, TPO
46testosterone46 62 25 1211.2CALCA, IL2RA, SERPINA7, TG, TPO, FASLG
47vegf468.2FASLG, TSHR, ICAM1, IFNG, IL2RA, CALCA
48arginine468.1IL2RA, IFNG, TSHR, SERPINA7, TG, TPO
49estrogen467.8CALCA, CTLA4, TSHR, IL2RA, TSHB, FASLG
50tyrosine467.2TG, TPO, AIRE, SERPINA7, TSHR, FASLG

GO Terms for genes affiliated with Thyroiditis

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17Gene Ontology
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Cellular components related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.9HLA-DRB4, TPO, FASLG, TSHR, ICAM1, CTLA4
2extracellular regionGO:0055767.9CALCA, IFNG, TSHB, FASLG, SERPINA7, TG
3external side of plasma membraneGO:0098977.9CTLA4, IL2RA, IFNG, ICAM1, FASLG, HLA-DRB4
4extracellular spaceGO:0056157.3TPO, TG, SERPINA7, FASLG, ICAM1, IFNG

Biological processes related to Thyroiditis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1TPO, TG
2thyroid hormone generationGO:00659010.0TG, TPO
3negative regulation of immune responseGO:05077710.0IL2RA, CTLA4
4leukocyte cell-cell adhesionGO:0071599.7ICAM1, CALCA
5extrinsic apoptotic signaling pathwayGO:0971919.6IFNG, FASLG
6inflammatory response to antigenic stimulusGO:0024379.5IL2RA, HLA-DRB4
7response to vitamin AGO:0331899.5TSHB, SERPINA7
8positive regulation of nitric oxide biosynthetic processGO:0454299.4IFNG, ICAM1
9cell-cell signalingGO:0072679.4FASLG, TSHR, TSHB, CALCA
10negative regulation of T cell proliferationGO:0421309.4HLA-DRB4, IL2RA, CTLA4
11interferon-gamma-mediated signaling pathwayGO:0603339.1IFNG, ICAM1, HLA-DRB4
12cytokine-mediated signaling pathwayGO:0192218.6IFNG, ICAM1, HLA-DRB4
13immune responseGO:0069558.5CTLA4, IL2RA, FASLG, HLA-DRB4, AIRE

Molecular functions related to Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CALCA, TSHB, TG

Products for genes affiliated with Thyroiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroiditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet