MCID: THY054
MIFTS: 48

Thyrotoxic Periodic Paralysis malady

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Thyrotoxic Periodic Paralysis

Aliases & Descriptions for Thyrotoxic Periodic Paralysis:

Name: Thyrotoxic Periodic Paralysis 50 56 29 69
Thyrotoxic Hypokalemic Periodic Paralysis 56

Characteristics:

Orphanet epidemiological data:

56
thyrotoxic periodic paralysis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA79102
UMLS via Orphanet 70 C0268446
ICD10 via Orphanet 34 G72.3

Summaries for Thyrotoxic Periodic Paralysis

MalaCards based summary : Thyrotoxic Periodic Paralysis, also known as thyrotoxic hypokalemic periodic paralysis, is related to thyrotoxic periodic paralysis 2 and thyrotoxic periodic paralysis 1, and has symptoms including periodic hypokalemic paresis, episodic hypokalemia and hyperhidrosis. An important gene associated with Thyrotoxic Periodic Paralysis is KCNJ18 (Potassium Voltage-Gated Channel Subfamily J Member 18), and among its related pathways/superpathways are Vascular smooth muscle contraction and Cardiac conduction. The drugs calcitonin and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and testes, and related phenotype is muscle.

Wikipedia : 71 Thyrotoxic periodic paralysis (TPP) is a condition featuring attacks of muscle weakness in the presence... more...

Related Diseases for Thyrotoxic Periodic Paralysis

Graphical network of the top 20 diseases related to Thyrotoxic Periodic Paralysis:



Diseases related to Thyrotoxic Periodic Paralysis

Symptoms & Phenotypes for Thyrotoxic Periodic Paralysis

Human phenotypes related to Thyrotoxic Periodic Paralysis:

56 32 (show all 42)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 periodic hypokalemic paresis 56 32 Obligate (100%) HP:0008153
2 episodic hypokalemia 56 32 Obligate (100%) HP:0012726
3 hyperhidrosis 56 32 Very frequent (99-80%) HP:0000975
4 obesity 56 32 Very frequent (99-80%) HP:0001513
5 palpitations 56 32 Very frequent (99-80%) HP:0001962
6 tetraplegia 56 32 Very frequent (99-80%) HP:0002445
7 hypomagnesemia 56 32 Very frequent (99-80%) HP:0002917
8 emg abnormality 56 32 Very frequent (99-80%) HP:0003457
9 episodic flaccid weakness 56 32 Very frequent (99-80%) HP:0003752
10 lower limb muscle weakness 56 32 Very frequent (99-80%) HP:0007340
11 mildly elevated creatine phosphokinase 56 32 Very frequent (99-80%) HP:0008180
12 transient hypophosphatemia 56 32 Very frequent (99-80%) HP:0008285
13 thyrotoxicosis with toxic multinodular goitre 56 32 Very frequent (99-80%) HP:0011785
14 thyrotoxicosis with toxic single thyroid nodule 56 32 Very frequent (99-80%) HP:0011786
15 increased intramyocellular lipid droplets 56 32 Very frequent (99-80%) HP:0012240
16 decreased urinary potassium 56 32 Very frequent (99-80%) HP:0012364
17 graves disease 56 32 Very frequent (99-80%) HP:0100647
18 urinary retention 56 32 Frequent (79-30%) HP:0000016
19 hyporeflexia 56 32 Frequent (79-30%) HP:0001265
20 tremor 56 32 Frequent (79-30%) HP:0001337
21 weight loss 56 32 Frequent (79-30%) HP:0001824
22 constipation 56 32 Frequent (79-30%) HP:0002019
23 rhabdomyolysis 56 32 Frequent (79-30%) HP:0003201
24 muscle cramps 56 32 Frequent (79-30%) HP:0003394
25 muscle stiffness 56 32 Frequent (79-30%) HP:0003552
26 exercise-induced muscle fatigue 56 32 Frequent (79-30%) HP:0009020
27 postprandial hyperglycemia 56 32 Frequent (79-30%) HP:0011998
28 prolonged qt interval 56 32 Occasional (29-5%) HP:0001657
29 ventricular fibrillation 56 32 Occasional (29-5%) HP:0001663
30 late-onset proximal muscle weakness 56 32 Occasional (29-5%) HP:0003694
31 shortened pr interval 56 32 Occasional (29-5%) HP:0005165
32 second degree atrioventricular block 56 32 Occasional (29-5%) HP:0011706
33 ophthalmoparesis 56 32 Very rare (<4-1%) HP:0000597
34 hyperkalemia 56 32 Very rare (<4-1%) HP:0002153
35 respiratory paralysis 56 32 Very rare (<4-1%) HP:0002203
36 hyperthyroidism 56 Obligate (100%)
37 paralysis 56 Very frequent (99-80%)
38 abnormality of muscle fibers 56 Very frequent (99-80%)
39 thyrotoxicosis with diffuse goiter 56 Very frequent (99-80%)
40 myotonia 56 Excluded (0%)
41 abnormality of peripheral nerve conduction 56 Excluded (0%)
42 impaired myocardial contractility 56 Excluded (0%)

MGI Mouse Phenotypes related to Thyrotoxic Periodic Paralysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.1 KCNJ2 ADRB2 ATP1A1 ATP1A2 ATP1B1 CACNA1S

Drugs & Therapeutics for Thyrotoxic Periodic Paralysis

Drugs for Thyrotoxic Periodic Paralysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 calcitonin
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:


id Name Status NCT ID Phase
1 Genetic Analysis of Thyrotoxic Periodic Paralysis Completed NCT00443833
2 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Active, not recruiting NCT02287363

Search NIH Clinical Center for Thyrotoxic Periodic Paralysis

Genetic Tests for Thyrotoxic Periodic Paralysis

Genetic tests related to Thyrotoxic Periodic Paralysis:

id Genetic test Affiliating Genes
1 Thyrotoxic Periodic Paralysis 29

Anatomical Context for Thyrotoxic Periodic Paralysis

MalaCards organs/tissues related to Thyrotoxic Periodic Paralysis:

39
Thyroid, Heart, Testes, Skeletal Muscle, Pituitary, Colon

Publications for Thyrotoxic Periodic Paralysis

Articles related to Thyrotoxic Periodic Paralysis:

(show top 50) (show all 234)
id Title Authors Year
1
Thyrotoxic periodic paralysis- A case report. ( 27728174 )
2016
2
Thyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease. ( 26676335 )
2016
3
Association of KCNJ2 Genetic Variants with Susceptibility to Thyrotoxic Periodic Paralysis in Patients with Graves' Disease. ( 28008586 )
2016
4
Thyrotoxic periodic paralysis-A case report. ( 27728198 )
2016
5
Whole genome and exome sequencing realignment supports the assignment of KCNJ12, KCNJ17, and KCNJ18 paralogous genes in thyrotoxic periodic paralysis locus: functional characterization of two polymorphic Kir2.6 isoforms. ( 27008341 )
2016
6
Thyrotoxic periodic paralysis: The immovable truth? A concise review of the literature. ( 27041083 )
2016
7
Thyrotoxic Periodic Paralysis: A Puzzling Case of Chest Pain and Weakness. ( 26817428 )
2016
8
Lower-Extremity Weakness in a Teenager Due to Thyrotoxic Periodic Paralysis. ( 27955984 )
2016
9
Steroid-induced thyrotoxic periodic paralysis during Graves' ophthalmopathy treatment. ( 27566533 )
2016
10
Thyrotoxic periodic paralysis. ( 27728745 )
2016
11
Is thyrotoxic periodic paralysis a disease caused by muscle membrane dysfunction? ( 28006864 )
2016
12
A Case of Nonfatal Ventricular Arrhythmia Due to Thyrotoxic Periodic Paralysis in a Saudi Patient as an Initial Presentation of Graves' Disease. ( 26843815 )
2016
13
A rare case of thyrotoxic periodic paralysis precipitated by hydrocortisone. ( 25810683 )
2015
14
Thyrotoxic periodic paralysis in long standing graves' disease: an unusual presentation with normokalemia. ( 25839004 )
2015
15
Normokalemic thyrotoxic periodic paralysis with preserved reflexes- a unique case report. ( 25859483 )
2015
16
Size of quadriceps femoris may contribute to thyrotoxic periodic paralysis. ( 26519100 )
2015
17
The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis. ( 25885757 )
2015
18
A case of thyrotoxic periodic paralysis with respiratory failure in an African American woman. ( 25934725 )
2015
19
Thyrotoxic Periodic Paralysis: An Underdiagnosed and Under-recognized Condition. ( 26623197 )
2015
20
Hypokalemia in thyrotoxic periodic paralysis: implication for nephrology practice. ( 24902491 )
2014
21
THYROTOXIC PERIODIC PARALYSIS, I^2-ADRENERGIC BRONCHODILATOR, AND INSULIN-AN INTERESTING INTERPLAY. ( 24742912 )
2014
22
Thyrotoxic periodic paralysis in a pediatric patient. ( 24378858 )
2014
23
Thyrotoxic periodic paralysis triggered by I^2-adrenergic bronchodilators. ( 24852589 )
2014
24
Evaluating the efficacy of primary treatment for graves' disease complicated by thyrotoxic periodic paralysis. ( 25147568 )
2014
25
Case of thyrotoxic periodic paralysis in a caucasian male and review of literature. ( 25484903 )
2014
26
IN REPLY TO "THYROTOXIC PERIODIC PARALYSIS, I^2-ADRENERGIC BRONCHODILATOR, AND INSULIN-AN INTERESTING INTERPLAY". ( 25227641 )
2014
27
Thyrotoxic periodic paralysis: clinical challenges. ( 24695373 )
2014
28
IN REPLY TO "THYROTOXIC PERIODIC PARALYSIS, I^2-ADRENERGIC BRONCHODILATOR, AND INSULIN-AN INTERESTING INTERPLAY". ( 24742350 )
2014
29
THYROTOXIC PERIODIC PARALYSIS, I^2-ADRENERGIC BRONCHODILATOR, AND INSULIN-AN INTERESTING INTERPLAY. ( 25227640 )
2014
30
A case of thyrotoxic periodic paralysis as initial manifestation of Graves' disease in a 16-year-old Korean adolescent. ( 25346923 )
2014
31
Thyrotoxic periodic paralysis: an endocrine cause of paraparesis. ( 24906287 )
2014
32
Thyrotoxic periodic paralysis triggered by I^2-adrenergic bronchodilators. ( 23816145 )
2013
33
Complete heart block during potassium therapy in thyrotoxic periodic paralysis. ( 22221982 )
2013
34
A rare case of thyrotoxic periodic paralysis with normokalemia. ( 23481615 )
2013
35
The predisposition to thyrotoxic periodic paralysis (TPP) is due to a genetic variant in the inward-rectifying potassium channel, KCNJ2. ( 23803013 )
2013
36
Episodes of paralysis in Chinese men with thyrotoxic periodic paralysis are associated with elevated serum testosterone. ( 23405854 )
2013
37
Thyrotoxic periodic paralysis: clinical and molecular aspects. ( 22918841 )
2013
38
Thyrotoxic periodic paralysis with Graves' disease leading to the discovery of a hidden nonclassic 11I^ hydroxylase deficiency. ( 23291679 )
2013
39
Thyrotoxic periodic paralysis: correct hypokalemia with caution. ( 23849367 )
2013
40
A 32-year-old Man with Normokalemic Thyrotoxic Periodic Paralysis. ( 23613659 )
2013
41
A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants. ( 23939916 )
2013
42
I Lost Weight, but I Became Weak and Cannot Walk-A Case of Nutraceutical (T3)-Induced Thyrotoxic Periodic Paralysis. ( 23567793 )
2013
43
Thyrotoxic periodic paralysis in Chinese patients: milder thyrotoxicosis yet lower dose of (131)I should be avoided. ( 23429401 )
2013
44
Thyrotoxic periodic paralysis presenting with ventricular storm. ( 22809769 )
2013
45
Thyrotoxic Periodic Paralysis: Diversity in America. ( 24315723 )
2013
46
Three cases of thyrotoxic periodic paralysis due to painless thyroiditis. ( 24251144 )
2013
47
Pop-provoked paralysis: silent Graves' disease presenting as thyrotoxic periodic paralysis. ( 23203166 )
2012
48
Thyrotoxic periodic paralysis in an 81-year-old diabetes patient with insulin treatment. ( 22748627 )
2012
49
Thyrotoxic periodic paralysis associated with transient thyrotoxicosis due to painless thyroiditis. ( 22787383 )
2012
50
Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India. ( 22919190 )
2012

Variations for Thyrotoxic Periodic Paralysis

ClinVar genetic disease variations for Thyrotoxic Periodic Paralysis:

6 (show all 12)
id Gene Variation Type Significance SNP ID Assembly Location
1 KCNJ18 NM_001194958.2(KCNJ18): c.429delC (p.Ile144Serfs) deletion Pathogenic,risk factor rs527236153 GRCh38 Chromosome 17, 21703215: 21703215
2 KCNJ18 NM_001194958.2(KCNJ18): c.1061C> T (p.Thr354Met) single nucleotide variant Pathogenic,risk factor rs527236158 GRCh38 Chromosome 17, 21703847: 21703847
3 KCNJ18 NM_001194958.2(KCNJ18): c.1097A> G (p.Lys366Arg) single nucleotide variant Pathogenic,risk factor rs527236159 GRCh38 Chromosome 17, 21703883: 21703883
4 CACNA1S NM_000069.2(CACNA1S): c.-476G> A single nucleotide variant risk factor rs2281845 GRCh37 Chromosome 1, 201081943: 201081943
5 CACNA1S NM_000069.2(CACNA1S): c.258+57G> A single nucleotide variant risk factor rs1325310 GRCh37 Chromosome 1, 201079235: 201079235
6 CACNA1S CACNA1S, IVS26, A-G (rs3831308) single nucleotide variant risk factor
7 KCNJ18 NM_001194958.2(KCNJ18): c.127C> T (p.Arg43Cys) single nucleotide variant Pathogenic rs527236151 GRCh38 Chromosome 17, 21702913: 21702913
8 KCNJ18 NM_001194958.2(KCNJ18): c.419C> T (p.Thr140Met) single nucleotide variant Pathogenic rs527236152 GRCh38 Chromosome 17, 21703205: 21703205
9 KCNJ18 NM_001194958.2(KCNJ18): c.502G> A (p.Val168Met) single nucleotide variant Pathogenic rs527236154 GRCh38 Chromosome 17, 21703288: 21703288
10 KCNJ18 NM_001194958.2(KCNJ18): c.598G> C (p.Ala200Pro) single nucleotide variant Pathogenic rs527236155 GRCh38 Chromosome 17, 21703384: 21703384
11 KCNJ18 NM_001194958.2(KCNJ18): c.1195C> T (p.Arg399Ter) single nucleotide variant Pathogenic rs527236156 GRCh38 Chromosome 17, 21703981: 21703981
12 KCNJ18 NM_001194958.2(KCNJ18): c.1219C> T (p.Gln407Ter) single nucleotide variant Pathogenic rs527236157 GRCh38 Chromosome 17, 21704005: 21704005

Expression for Thyrotoxic Periodic Paralysis

Search GEO for disease gene expression data for Thyrotoxic Periodic Paralysis.

Pathways for Thyrotoxic Periodic Paralysis

Pathways related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
2
Show member pathways
12.75 ATP1A1 ATP1A2 ATP1B1 ATP1B2 CACNA1S KCNJ2
3
Show member pathways
12.7 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
4
Show member pathways
12.56 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
5
Show member pathways
12.45 ATP1A1 ATP1A2 ATP1B1 ATP1B2 GABRA3
6
Show member pathways
12.39 ADRB2 ATP1B1 ATP1B2 CACNA1S
7
Show member pathways
12.31 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 CACNA1S
8 12.15 CACNA1S KCNJ16 KCNJ2
9 12 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
10
Show member pathways
12 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 CACNA1S
11
Show member pathways
11.91 GABRA3 KCNJ16 KCNJ2
12 11.9 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
13
Show member pathways
11.86 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
14 11.76 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
15 11.63 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 CACNA1S
16 11.58 ADRB2 CACNA1S KCNJ2
17 11.58 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
18 11.53 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
19 11.5 ADRB2 ATP1A1 KCNJ2
20 11.45 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
21
Show member pathways
11.44 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
22 11.29 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
23 11.27 ADRB2 TSHR
24 11.15 ADRB2 TSHR
25 11.04 ATP1B1 ATP1B2
26 10.92 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4

GO Terms for Thyrotoxic Periodic Paralysis

Cellular components related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 ADRB2 ATP1B4 GABRA3 KCNJ16 KCNJ18 KCNJ2
2 apical plasma membrane GO:0016324 9.8 ADRB2 ATP1A1 ATP1B1 ATP1B2
3 basolateral plasma membrane GO:0016323 9.73 ATP1A1 ATP1B1 KCNJ16 TSHR
4 myelin sheath GO:0043209 9.7 ATP1A1 ATP1A2 ATP1B1
5 sarcolemma GO:0042383 9.69 ATP1A1 ATP1A2 ATP1B1
6 caveola GO:0005901 9.65 ATP1A1 ATP1A2 ATP1B1
7 extracellular vesicle GO:1903561 9.63 ATP1A1 ATP1A2 ATP1B1
8 intercalated disc GO:0014704 9.46 ATP1A1 ATP1A2 ATP1B1 KCNJ2
9 T-tubule GO:0030315 9.26 ATP1A1 ATP1A2 CACNA1S KCNJ2
10 sodium:potassium-exchanging ATPase complex GO:0005890 9.02 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
11 membrane GO:0016020 10.18 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
12 plasma membrane GO:0005886 10.06 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 CACNA1S
13 integral component of membrane GO:0016021 10.03 ADRB2 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4

Biological processes related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.97 ATP1A1 ATP1A2 ATP1B1 ATP1B2 GABRA3
2 ion transport GO:0006811 9.96 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 CACNA1S
3 sodium ion transport GO:0006814 9.92 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4
4 regulation of ion transmembrane transport GO:0034765 9.89 CACNA1S KCNJ16 KCNJ18 KCNJ2
5 regulation of cardiac conduction GO:1903779 9.85 ATP1A1 ATP1A2 ATP1B1 ATP1B2
6 cellular response to mechanical stimulus GO:0071260 9.8 ATP1A1 ATP1A2 KCNJ2
7 cellular sodium ion homeostasis GO:0006883 9.8 ATP1A1 ATP1A2 ATP1B1 ATP1B2
8 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.78 ATP1A1 ATP1A2 ATP1B1 ATP1B2
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.76 ATP1A1 ATP1A2 ATP1B1 ATP1B2
10 regulation of cardiac muscle cell contraction GO:0086004 9.74 ATP1A1 ATP1A2 KCNJ2
11 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.73 ATP1A1 ATP1B1 KCNJ2
12 relaxation of cardiac muscle GO:0055119 9.73 ATP1A1 ATP1A2 ATP1B1 KCNJ2
13 potassium ion import across plasma membrane GO:1990573 9.71 ATP1A1 ATP1A2 ATP1B1
14 membrane repolarization GO:0086009 9.71 ATP1A1 ATP1A2 ATP1B1 ATP1B2
15 cardiac muscle contraction GO:0060048 9.67 ATP1A2 ATP1B1
16 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.67 ADRB2 TSHR
17 ATP hydrolysis coupled transmembrane transport GO:0090662 9.67 ATP1A1 ATP1A2 ATP1B1 ATP1B2
18 activation of adenylate cyclase activity GO:0007190 9.66 ADRB2 TSHR
19 ATP metabolic process GO:0046034 9.66 ATP1A2 ATP1B1
20 positive regulation of ATPase activity GO:0032781 9.65 ATP1B1 ATP1B2
21 regulation of sodium ion transport GO:0002028 9.65 ADRB2 ATP1A1
22 regulation of the force of heart contraction GO:0002026 9.65 ATP1A1 ATP1A2
23 regulation of smooth muscle contraction GO:0006940 9.64 ADRB2 ATP1A2
24 cardiac muscle cell action potential involved in contraction GO:0086002 9.64 ATP1A1 KCNJ2
25 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.63 ATP1A2 KCNJ2
26 cellular response to steroid hormone stimulus GO:0071383 9.63 ATP1A1 ATP1A2
27 negative regulation of heart contraction GO:0045822 9.62 ATP1A1 ATP1A2
28 sodium ion export from cell GO:0036376 9.62 ATP1A1 ATP1A2 ATP1B1 ATP1B2
29 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.61 ATP1B1 ATP1B2
30 response to glycoside GO:1903416 9.61 ATP1A1 ATP1A2
31 positive regulation of sodium ion export from cell GO:1903278 9.6 ATP1B1 ATP1B2
32 positive regulation of potassium ion import GO:1903288 9.58 ATP1B1 ATP1B2
33 potassium ion transport GO:0006813 9.56 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 KCNJ16
34 cellular potassium ion homeostasis GO:0030007 9.55 ATP1A1 ATP1A2 ATP1B1 ATP1B2 KCNJ2
35 potassium ion import GO:0010107 9.17 ATP1A1 ATP1A2 ATP1B1 ATP1B2 KCNJ16 KCNJ18
36 transport GO:0006810 10.21 ATP1A1 ATP1A2 ATP1B1 ATP1B2 ATP1B4 CACNA1S

Molecular functions related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.62 CACNA1S KCNJ16 KCNJ18 KCNJ2
2 ATPase activator activity GO:0001671 9.43 ATP1B1 ATP1B2
3 inward rectifier potassium channel activity GO:0005242 9.43 KCNJ16 KCNJ18 KCNJ2
4 G-protein activated inward rectifier potassium channel activity GO:0015467 9.4 KCNJ16 KCNJ2
5 steroid hormone binding GO:1990239 9.37 ATP1A1 ATP1A2
6 potassium ion binding GO:0030955 9.33 ATP1A1 ATP1A2 ATP1B1
7 sodium ion binding GO:0031402 9.13 ATP1A1 ATP1A2 ATP1B1
8 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1A1 ATP1A2 ATP1B1 ATP1B2

Sources for Thyrotoxic Periodic Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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