MCID: THY033
MIFTS: 57

Thyrotoxicosis malady

Endocrine diseases category

Summaries for Thyrotoxicosis

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

MalaCards: Thyrotoxicosis is related to thyroiditis and neonatal thyrotoxicosis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are G alpha (s) signalling events and Hormone ligand-binding receptors. The drugs thyroglobulin and thyroid (usp) and the compounds sodium iodide and asparagine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hearing/vestibular/ear and reproductive system.

Disease Ontology:9 A thyroid gland disease that is characterized by excess thyroid hormone.

Description from OMIM:48 275000

Aliases & Classifications for Thyrotoxicosis

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 48OMIM, 36MeSH, 41NCIt, 28ICD9CM, 26ICD10
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Related Diseases for Thyrotoxicosis

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18GeneCards, 19GeneDecks
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Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3TG, TSHR, CGA
2neonatal thyrotoxicosis31.2LHX3, TSHR
3hypothyroidism30.7TG, TSHR
4graves' disease30.7CGA, TSHR, DIO2, TG
5goiter30.6DIO2, TSHR, TG, TXNRD2
6hyperthyroidism30.6TXNRD2, TG, TSHR, DIO2, CGA
7myxedema30.5TSHR, TG
8subacute thyroiditis30.5TSHR, TG
9multinodular goiter30.4TSHR, TG
10thyroid cancer30.3TSHR, TG, TXNRD2
11endemic goiter30.3TG, TSHR
12nodular goiter30.2TG, TSHR
13hypopituitarism30.2LHX3, CGA
14autoimmune thyroiditis30.2TG, TSHR
15toxic diffuse goiter30.1TG, TSHR
16struma ovarii30.1TG, TSHR
17follicular thyroid carcinoma30.1TG, TSHR
18adenoma30.0TXNRD2, TG, TSHR, DIO2, CGA
19thyroid adenoma29.9TSHR, DIO2, TG, TXNRD2
20nontoxic goiter29.8TG, TSHR
21papillary thyroid carcinoma29.8TSHR, TG
22papillary carcinoma29.8TG, TSHR
23infertility29.7TXNRD2, CGA
24suppurative thyroiditis10.3
25hypertension10.3
26exophthalmos10.3
27hypokalemic periodic paralysis10.3
28hepatitis10.3
29thymic hyperplasia10.3
30cerebritis10.2
31pernicious anemia10.1
32exophthalmic ophthalmoplegia10.1
33myocardial infarction10.1
34ophthalmoplegia10.1
35thyrotoxic periodic paralysis10.1
36venous thrombosis10.1
37pendred syndrome10.1TG
38hepatitis c10.1
39periarthritis10.1
40hyperthyroxinemia10.1
41pituitary apoplexy10.1
42diabetes insipidus10.1
43hypercalcemia10.1
44sick sinus syndrome10.1
45choriocarcinoma10.1
46congenital heart disease10.1
47congestive heart failure10.1
48diabetes mellitus10.1
49myasthenia gravis10.1
50chorea10.1

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Symptoms for Thyrotoxicosis

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48OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Thyrotoxicosis

Drug clinical trials:

Search ClinicalTrials for Thyrotoxicosis

Search NIH Clinical Center for Thyrotoxicosis

Search CenterWatch for Thyrotoxicosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Thyrotoxicosis

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Anatomical Context for Thyrotoxicosis

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34MalaCards
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MalaCards organs/tissues related to Thyrotoxicosis:

34
Thyroid, Heart, Pituitary, Bone, Testes, Liver, Brain, Bone marrow

Animal Models for Thyrotoxicosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Thyrotoxicosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6HCN2, LHX3, TSHR
2MP:00053898.3CGA, TSHR, LHX3, HCN2
3MP:00053798.1LHX3, TG, TSHR, DIO2, CGA
4MP:00036317.5CGA, TSHR, TG, TXNRD2, LHX3, HCN2
5MP:00053767.5LHX3, TXNRD2, TG, TSHR, DIO2, CGA
6MP:00053787.2HCN2, LHX3, TG, TSHR, DIO2, CGA

Publications for Thyrotoxicosis

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Sources:
53PubMed
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Articles related to Thyrotoxicosis:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
Management of severe amiodarone-induced thyrotoxicosis after failure of standard medical treatment. (23540613)
2013
2
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
3
Increased sex hormone-binding globulin levels in children and adolescents with thyrotoxicosis. (23548728)
2013
4
Body mass index and the development of amiodarone-induced thyrotoxicosis in adults with congenital heart disease--a cohort study. (22386642)
2013
5
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
6
Gynaecomastia as the initial presentation of thyrotoxicosis. (23565425)
2012
7
Total thyroidectomy for amiodarone-associated thyrotoxicosis: should surgery always be delayed for pre-operative medical preparation? (22613770)
2012
8
Thyrotoxicosis presenting as acute bulbar palsy. (21751598)
2011
9
Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis. (20551140)
2011
10
The association of insulin resistance with subclinical thyrotoxicosis. (21834678)
2011
11
Resistant thyrotoxicosis in a patient with graves disease: a case report. (21845211)
2011
12
Thyrotoxicosis. (21819001)
2011
13
Takotsubo cardiomyopathy precipitated by thyrotoxicosis. (21054211)
2010
14
Repetitive monomorphic ventricular tachycardia as a manifestation of suboptimally treated thyrotoxicosis. (22022738)
2010
15
Thyrotoxicosis factitia induces Takotsubo cardiomyopathy in end-stage renal disease: a pathogenetic hypothesis. (20150943)
2010
16
The correlation between left ventricular failure and right ventricular systolic dysfunction occurring in thyrotoxicosis. (20589198)
2010
17
A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. (19628289)
2010
18
Iodinated contrast prior to evaluation for thyrotoxicosis. (19263484)
2009
19
A Case of Amiodarone-Induced Thyrotoxicosis: A diagnostic and therapeutic dilemma. (21509317)
2009
20
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
21
Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism. (18941937)
2008
22
Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004. (18602654)
2008
23
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
24
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
25
Impact of thyroid metabolism on the course of INR levels in a patient with systemic anticoagulation suffering from amiodarone-induced thyrotoxicosis. (17943696)
2007
26
Tailor treatment to the patient in thyrotoxicosis. (17784663)
2007
27
Thyrotoxicosis with coronary spasm that required coronary artery bypass surgery. (18057764)
2007
28
Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome. (17572251)
2007
29
Management of amiodarone-induced thyrotoxicosis in Latin America: an electronic survey. (16984234)
2006
30
Cardiomyopathy and thyrotoxicosis: tachycardiomyopathy or thyrotoxic cardiomyopathy? (16485742)
2006
31
A cluster of thyrotoxicosis associated with consumption of a soy milk product. (16366059)
2005
32
Secondary osteoporosis: thyrotoxicosis, rheumatoid arthritis, and diabetes mellitus. (15221485)
2004
33
Contrast-induced thyrotoxicosis. (15332308)
2004
34
Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum--report of two cases. (15763786)
2004
35
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
36
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
37
Thyrotoxicosis--surgical management in the era of evidence-based medicine: experience in western India with 752 cases. (12471001)
2002
38
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
39
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
40
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
41
Thyrotoxicosis presenting as generalized pruritic exfoliative dermatitis and fever. (1386765)
1992
42
Choriogonadotropin-mediated thyrotoxicosis in a man. (2049833)
1991
43
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
44
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. (6637335)
1983
45
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
46
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
47
Concomitant pernicious anemia and thyrotoxicosis. A case report and discussion. (5409998)
1970
48
Thyrotoxicosis and gigantism associated with "Klinefelter's syndrome". (5850468)
1965
49
Neonatal thyrotoxicosis. (13731873)
1960
50
Uropepsin excretion in neurocirculatory asthenia and thyrotoxicosis. (13381999)
1956

Variations for Thyrotoxicosis

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Expression for genes affiliated with Thyrotoxicosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Compounds for genes affiliated with Thyrotoxicosis

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46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank, 3BitterDB, 52PharmGKB
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Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1sodium iodide469.9TSHR, TG
2asparagine469.8TXNRD2, TSHR
3cytosine46 2510.8TSHR, TXNRD2
4prednisolone46 30 1211.7TSHR, TG
5selenocysteine46 25 1211.7DIO2, TXNRD2
6carbohydrates469.6TSHR, TG
7adenine46 25 1211.5TSHR, TXNRD2
8guanine46 25 1211.5TXNRD2, TG, TSHR
9sialic acid469.4CGA, TSHR, TG
10thymidine46 2510.4TSHR, TG, TXNRD2
11paraffin469.4TG, TSHR, CGA
12propylthiouracil46 3 1211.4TG, TSHR, DIO2
13iodine46 2510.4DIO2, TSHR, TG
14125i469.4DIO2, TSHR, TG
15iodide46 2510.4TG, TSHR, DIO2
16methimazole46 3 1211.4DIO2, TSHR, TG
17adenylate469.3CGA, TSHR, TG
18forskolin46 52 1211.3CGA, DIO2, TSHR
19selenium46 2510.3DIO2, TG, TXNRD2
20h2o2469.2CGA, TG, TXNRD2
21vegf469.2TG, TSHR, CGA
22carbachol46 30 1211.1CGA, TG
23threonine469.1DIO2, TSHR, TXNRD2
24glutamate469.1TG, TSHR, CGA
25cycloheximide469.0CGA, DIO2, TG
26sodium46 2510.0HCN2, TG, TSHR
27cyclic amp46 2510.0HCN2, TSHR, CGA
28aspartate469.0TXNRD2, TG, TSHR, CGA
29arginine468.9CGA, TSHR, TG, TXNRD2
30retinoic acid46 259.8DIO2, TSHR, TG, TXNRD2
31ribonucleic acid468.8TG, TSHR, DIO2, CGA
32tyrosine468.4LHX3, TXNRD2, TG, TSHR, DIO2
33triiodothyronine468.4CGA, DIO2, TSHR, TG, TXNRD2
34thyroxine46 259.4TXNRD2, TG, TSHR, DIO2, CGA
35alanine468.4CGA, DIO2, TSHR, TG, TXNRD2
36estrogen468.4TXNRD2, TG, TSHR, DIO2, CGA
37serine468.3TXNRD2, TG, TSHR, DIO2, CGA
38cysteine467.7DIO2, TSHR, TG, TXNRD2, LHX3, HCN2

GO Terms for genes affiliated with Thyrotoxicosis

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17Gene Ontology
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Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.2DIO2, TG
2thyroid gland developmentGO:0308789.1TG, CGA
3thyroid hormone generationGO:0065908.8CGA, DIO2, TG
4cell-cell signalingGO:0072678.8CGA, TSHR, HCN2

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4CGA, TG

Products for genes affiliated with Thyrotoxicosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyrotoxicosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet