MCID: THY033
MIFTS: 55

Thyrotoxicosis malady

Endocrine category

Summaries for Thyrotoxicosis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

MalaCards: Thyrotoxicosis is related to neonatal thyrotoxicosis and thyroiditis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Regulation of thyroid hormone activity. The drugs thyroglobulin and thyroid (usp) and the compounds cycloheximide and forskolin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are endocrine/exocrine gland and growth/size.

Description from OMIM:47 275000

Aliases & Classifications for Thyrotoxicosis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 47OMIM, 35MeSH, 40NCIt, 25ICD10
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Related Diseases for Thyrotoxicosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal thyrotoxicosis31.1TSHR, LHX3
2thyroiditis30.9CGA, TG, TPO, TSHR, SERPINA7, TRH
3graves' disease30.8TG, DIO2, TPO, TSHR, SERPINA7, LMOD1
4myxedema30.4TG, TPO, TSHR
5exophthalmos30.4TRH, TSHR
6subacute thyroiditis30.3TG
7multinodular goiter30.3TG, TSHR, TPO
8thyroid cancer30.3TSHR, TG, TPO
9endemic goiter30.2TG, TPO, TSHR
10pernicious anemia30.2TPO, TG
11adenoma30.1TPO, TG, TSHR, LMOD1, TXNRD2, CA1
12diabetes insipidus30.1TRH
13nodular goiter30.1TPO, TSHR, TG
14hyperthyroxinemia30.1SERPINA7, TSHR, TRH, TPO
15struma ovarii29.9TG, TSHR
16autoimmune thyroiditis29.9TG, TPO
17toxic diffuse goiter29.9TG, TPO, TSHR
18papillary carcinoma29.9TPO, TSHR, TG
19thyroid adenoma29.9TXNRD2, DIO2, TG, TPO, TSHR, SERPINA7
20cushing's syndrome29.7TRH
21acth deficiency29.7PROP1
22nontoxic goiter29.7TSHR, TPO, TG
23thyroid hormone resistance syndrome29.7TG, SERPINA7, TRH, TXNRD2
24addison's disease29.7TG, TPO
25klinefelter's syndrome29.7CGA, PROP1, TRH
26infertility29.7IL11, CGA, TPO, TXNRD2
27tuberculosis29.7IL11, TPO
28thyrotoxic periodic paralysis10.4
29acute thyroiditis10.4
30suppurative thyroiditis10.3
31hypokalemic periodic paralysis10.3
32thyrotoxic exophthalmos10.3
33thymic hyperplasia10.2
34hepatitis c10.2
35wernicke encephalopathy10.2
36exophthalmic ophthalmoplegia10.1
37neonatal hypothyroidism10.1
38venous thrombosis10.1
39periarthritis10.1
40pituitary apoplexy10.1
41hypercalcemia10.1
42sick sinus syndrome10.1
43n syndrome10.1
44chorea10.1
45diabetes mellitus10.0SORD
46endogenous depression10.0TRH
47dwarfism10.0PROP1
48euthyroid sick syndrome10.0TRH, SERPINA7
49hypersensitivity reaction type ii disease10.0TRH, TSHR
50hypertension10.0ADM

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Clinical Features for Thyrotoxicosis

Sources:
47OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Thyrotoxicosis

Drug clinical trials:

Search ClinicalTrials for Thyrotoxicosis

Search NIH Clinical Center for Thyrotoxicosis

Search CenterWatch for Thyrotoxicosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Thyrotoxicosis

Anatomical Context for Thyrotoxicosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Thyrotoxicosis:

33
Bone marrow, Brain, Heart, Skeletal muscle, Liver, Thyroid, Adrenal gland, T cells, B cells, Fetal brain, Fetal liver, Fetal thyroid, Pituitary

Animal Models for Thyrotoxicosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Thyrotoxicosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7PROP1, TG, TPO, TSHR, LHX3, TRH
2MP:00053789.0TG, DIO2, TPO, TSHR, HCN2, TRH
3MP:00053768.7TXNRD2, TG, TPO, ADM, TSHR, SLPI

Publications for Thyrotoxicosis

Sources:
51PubMed
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Articles related to Thyrotoxicosis:

(show top 50)    (show all 682)
idTitleAuthorsYear
1
Evaluating and managing patients with thyrotoxicosis. (23145395)
2012
2
Periodic paralysis: an unusual presentation of thyrotoxicosis. (22111099)
2011
3
Takotsubo cardiomyopathy in thyrotoxicosis. (19897260)
2010
4
Amiodarone and thyrotoxicosis: case reports. (21225109)
2010
5
Iodinated contrast prior to evaluation for thyrotoxicosis. (19263484)
2009
6
Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome. (18940876)
2009
7
Glucocorticoids are preferable to thionamides as first-line treatment for amiodarone-induced thyrotoxicosis due to destructive thyroiditis: a matched retrospective cohort study. (19622616)
2009
8
Iodized salt induced thyrotoxicosis: Bangladesh perspective. (19623141)
2009
9
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
10
Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004. (18602654)
2008
11
Normal neurological outcome after congenital thyrotoxicosis: prognostic value of observation of general movements. (19569001)
2008
12
Thyrotoxicosis after iodine contrast medium administration: rapid mood swing to mania and subsequent psychotic depression in a patient with bipolar disorder during lithium therapy. (18651349)
2008
13
Papillary carcinoma of the thyroid gland in a child of thyrotoxicosis patient receiving radioactive iodine therapy: report of a case. (18414877)
2008
14
Uncommon causes of thyrotoxicosis. (18199610)
2008
15
Diagnosis and management of amiodarone-induced thyrotoxicosis: similarities and differences between North American and European thyroidologists. (18410546)
2008
16
Autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring euthyroidism. (18397977)
2008
17
Treatment of amiodarone-associated thyrotoxicosis. (17710087)
2007
18
Neuromuscular complications of thyrotoxicosis. (17561978)
2007
19
Thyrotoxicosis presenting as hypokalaemic paralysis and hyperlactataemia in an oriental man. (16824287)
2006
20
Analysis of the factors associated with Tc-99m pertechnetate uptake in thyrotoxicosis and graves' disease. (16538017)
2006
21
Total thyroidectomy for amiodarone-associated thyrotoxicosis in patients with severe cardiac disease. (17043940)
2006
22
Thyrotoxicosis during pegylated interferon therapy in a patient with chronic hepatitis C virus. (16690473)
2006
23
Radiation exposure to family members of patients with thyrotoxicosis treated with iodine-131. (16151768)
2006
24
Effects of CPU 86017 (chlorobenzyltetrahydroberberine chloride) and its enantiomers on thyrotoxicosis-induced overactive endothelin-1 system and oxidative stress in rat testes. (16904483)
2006
25
Rectal administration of propylthiouracil in suppository form in patients with thyrotoxicosis and critical illness: case report and review of literature. (16524862)
2006
26
Presumed dapsone-induced drug hypersensitivity syndrome causing reversible hypersensitivity myocarditis and thyrotoxicosis. (17160201)
2006
27
Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis. (16284430)
2005
28
Treating amiodarone-induced thyrotoxicosis with radioactive iodine. (15497570)
2004
29
Clinical approach to thyrotoxicosis. (15160477)
2004
30
Scintigraphy for risk stratification of iodine-induced thyrotoxicosis in patients receiving contrast agent for coronary angiography: a prospective study of patients with low thyrotropin. (15579763)
2004
31
Hypokalemic periodic paralysis as a presenting manifestation of thyrotoxicosis. (23377367)
2004
32
Postoperative endocrine function in patients with surgically treated thyrotoxicosis. (15054736)
2004
33
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
34
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
35
TSH-receptor antibody measurement in patients with various thyrotoxicosis and Hashimoto's thyroiditis: a comparison of two two-step assays, coated plate ELISA using porcine TSH-receptor and coated tube radioassay using human recombinant TSH-receptor. (12733717)
2003
36
Thyrotoxicosis after complete or partial lithium withdrawal in two patients with bipolar affective disorder. (14525561)
2003
37
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. (12962270)
2003
38
Thyrotoxicosis--surgical management in the era of evidence-based medicine: experience in western India with 752 cases. (12471001)
2002
39
Thyrotoxicosis associated with sick sinus syndrome: a diagnostic and therapeutic dilemma. (4001616)
1985
40
Triggering of acute calcific periarthritis by thyrotoxicosis. (6697077)
1984
41
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
42
Hypertension in neonatal thyrotoxicosis. (7069539)
1982
43
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
44
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. (6998280)
1980
45
Neonatal thyrotoxicosis: a rare pediatric emergency. (6893645)
1980
46
Herpes gestationis. A possible association with autoimmune thyrotoxicosis (Graves' disease). (7012197)
1980
47
Corticotropin-induced hyperaldosteronism; causing hypokalemic paralysis of thyrotoxicosis. (6262690)
1980
48
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. (946443)
1976
49
A further report on exophthalmic ophthalmoplegia and its relation to thyrotoxicosis. (14846860)
1951
50
Thyrotoxicosis with Unilateral Exophthalmos, Hyperpituitarism, and Infantile Hemiplegia. (19990197)
1935

Genetic Variations for Thyrotoxicosis

Expression for genes affiliated with Thyrotoxicosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Thyrotoxicosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.2TPO, DIO2
3
Hide members
10.1TSHR, TPO, TG
410.1DIO2, DIO3, TXNRD2
510.1DIO2, DIO3, TXNRD2

Compounds for genes affiliated with Thyrotoxicosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6TRH, DIO2
2forskolin45 50 1112.5IL11, TSHR, ADM
3sodium iodide4510.4TSHR, TPO, TG
43,3-diiodothyronine4510.4DIO3, LMOD1, DIO2
5Liothyronine11 2411.3DIO2, TPO, SERPINA7
6amiodarone45 50 29 1113.3TG, TPO, SERPINA7, LMOD1
7selenium45 2411.3TG, DIO2, TPO, TXNRD2
8selenocysteine45 11 2412.3LMOD1, TXNRD2, DIO3, DIO2
9methimazole45 2 1112.2SERPINA7, TSHR, DIO2, TPO, TG, TRH
10n-bromoacetyl-3,3,5-triiodo-l-thyronine4510.2DIO2, LMOD1
11propylthiouracil45 2 1112.2TSHR, TPO, LMOD1, DIO2, DIO3, TG
12dithiothreitol4510.1TRH, DIO2, TPO, DIO3, LMOD1
13iodotyrosine45 2411.1TPO, TG
14asparagine4510.1TPO, TSHR, TXNRD2, SERPINA7
15hydrocortisone45 2 60 1113.1TRH, SLPI, ADM, TPO, TG
16serine4510.1TSHR, CGA, DIO2, TXNRD2, PROP1
17gnrh4510.1LHX3, CGA, CGB7, PROP1, TRH
18carbachol45 29 1112.1CGA, SLPI, IL11, ADM, TG
19acetylcholine45 50 29 11 2414.1TPO, ADM, TRH
20iodine45 2411.0TG, TPO, LMOD1, TSHR, SERPINA7, TRH
21iodide45 2411.0LMOD1, TG, TPO, SERPINA7, DIO3, DIO2
22ribonucleic acid4510.0IL11, TG, TPO, TSHR, CGA, SERPINA7
23acth4510.0ADM, TSHR, TRH, SERPINA7, IL11, PROP1
24dexamethasone45 50 29 1113.0TRH, DIO3, SLPI, LMOD1, DIO2
25norepinephrine45 11 2412.0ADM, TG, TRH, CGA, CA1, SLPI
26thymidine45 2410.9TRH, IL11, SLPI, TXNRD2, TG, ADM
27125i459.9ADM, TPO, TSHR, TG, DIO3, DIO2
28hydrogen45 2410.9TXNRD2, TSHR, TRH, SORD, TPO, CA1
29creatinine459.9CGA, SLPI, SORD, ADM, TPO, TG
30progesterone45 60 29 11 2413.9SERPINA7, ADM, TSHR, IL11, TRH, CGB7
31lactate459.9SLPI, ADM, CGB7, TG, CGA, SORD
32cyclic amp45 2410.9CGA, SLPI, TSHR, TRH, HCN2, IL11
33sodium45 2410.9HCN2, SLPI, TSHR, TPO, TG, ADM
34dopamine45 29 11 2412.8IL11, SERPINA7, LMOD1, TRH, CGA, DIO2
35steroid459.8SLPI, IL11, PROP1, CGA, TXNRD2, TPO
36adenylate459.8TRH, CGA, TG, TSHR, ADM, TPO
37arginine459.8SERPINA7, TRH, CGA, TXNRD2, CA1, TSHR
38estradiol45 11 2411.8TSHR, SERPINA7, IL11, TRH, CGB7, CGA
39oligonucleotide459.7TPO, TRH, IL11, TSHR, SLPI, SORD
40aspartate459.7IL11, SORD, TXNRD2, TSHR, TPO, CGA
41retinoic acid45 2410.7DIO2, TXNRD2, CGB7, IL11, SLPI, TPO
42triiodothyronine459.7DIO2, TXNRD2, DIO3, CGA, TRH, LMOD1
43glucose459.7SLPI, SORD, DIO2, TRH, IL11, SERPINA7
44mannitol45 1110.6ADM, SLPI, CGA, SORD
45testosterone45 60 11 2412.5TPO, SORD, CGA, CGB7, PROP1, SLPI
46thyroxine45 2410.5TG, TPO, TSHR, SERPINA7, TRH, CGB7
47alanine459.5TG, ADM, TSHR, SERPINA7, SLPI, CGA
48estrogen459.4CGA, TG, ADM, TSHR, SLPI, LMOD1
49tyrosine459.3LHX3, DIO2, TRH, IL11, LMOD1, SERPINA7
50cysteine459.2HCN2, IL11, TG, LMOD1, DIO3, ADM

GO Terms for genes affiliated with Thyrotoxicosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3TG, ADM, SERPINA7, SLPI, IL11, PCDHA1

Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.2TG, CGA
2hormone biosynthetic processGO:04244610.0DIO3, DIO2, TPO, TG
3thyroid hormone generationGO:0065909.9TG, TPO, CGA, DIO2, DIO3
4response to corticosterone stimulusGO:0514129.9SERPINA7, TRH
5cell-cell signalingGO:0072679.6CGA, TRH, HCN2, IL11, TSHR, ADM

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.1TG, ADM, CGA
2thyroxine 5-deiodinase activityGO:0048009.9DIO2, DIO3

Products for genes affiliated with Thyrotoxicosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyrotoxicosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet