Thyrotoxicosis malady

Wikipedia: Hyperthyroidism, often referred to as an \'overactive thyroid\', is a condition in which the thyroid...⁴⁴ more...

MalaCards: Thyrotoxicosis is related to neonatal thyrotoxicosis and hyperthyroxinemia. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Regulation of thyroid hormone activity and Hematopoietic cell lineage. The drugs potassium iodide and thyroglobulin and the compounds estradiol and propylthiouracil have been mentioned in the context of this disorder. Affiliated tissues include heart, thyroid and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

thyrotoxicosis 6 43

Diseases related to thyrotoxicosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 531)

id	Related Disease	Score	Top Affiliating Genes
1	neonatal thyrotoxicosis	32.3	LHX3, TXNRD2, TRH, DIO3, TSHR, PROP1
2	hyperthyroxinemia	29.1	ALB, TRH, TPO, TTR, TSHR
3	subacute thyroiditis	28.2	TPO, TSHR, TG
4	hypothyroidism	28.0	LEP, IFNA1, GHRL, TRH, TPO, TSHR
5	myxedema	27.4	TPO, TSHR, TG, NPPA
6	dysalbuminemic hyperthyroxinemia	27.2	ALB, TTR
7	endogenous depression	27.1	INS, GNRH1, TRH, TPO, TG
8	autoimmune thyroiditis	26.7	LMOD1, IL2RA, CALCA, GHRL, TPO, TSHR
9	hypocalcemia	26.1	BGLAP, CD36, ALB, ALPP, CALCA, SLPI
10	insulinoma	26.0	SDHB, INS, IL11, CALCA, GH1, GHRL
11	thyroid carcinoma	25.1	BGLAP, MTHFR, CGA, CD36, IL2, IL2RA
12	atrial fibrillation	24.6	MTHFR, CD36, INS, ALB, TRH, TPO
13	congestive heart failure	24.3	CD36, INS, IL2RA, ALB, CALCA, TTR
14	infertility	23.1	LEP, MTHFR, CGA, INS, IL11, ALB
15	thrombosis	22.1	BGLAP, LEP, MTHFR, CD36, INS, IL2
16	graves' disease	22.1	LMOD1, BGLAP, MTHFR, CGA, CD36, INS
17	sinusitis	21.6	BGLAP, MTHFR, CGA, CGB7, INS, IL2
18	hepatitis c	21.1	LEP, MTHFR, CD36, INS, IL11, IL2
19	hyperthyroidism	20.3	LMOD1, BGLAP, SDHB, LEP, CGA, CGB7
20	thyroiditis	20.2	LMOD1, BGLAP, SDHB, LHX3, LEP, MTHFR
21	cerebritis	19.2	BGLAP, SDHB, LEP, MTHFR, CGA, CD36
22	carcinoma	18.7	LMOD1, BGLAP, SDHB, LEP, MTHFR, CGA
23	hepatitis	18.3	LMOD1, BGLAP, SDHB, LEP, MTHFR, CGA
24	thyroid hormone resistance syndrome	13.7	TXNRD2, TRH, TG
25	atrophy of thyroid	13.7	TRH, TPO
26	total iodide organification defect	13.7	TPO, TG
27	iodine hypothyroidism	13.7	TPO, TG
28	hashimoto's encephalitis	13.7	TPO, TG
29	toxic diffuse goiter	13.6	TPO, TSHR, TG
30	neonatal hypothyroidism	13.6	TPO, TSHR, TG
31	megaloblastic anemia	13.6	TPO, TG
32	generalized resistance to thyroid hormone	13.6	TXNRD2, TRH
33	trabecular adenoma	13.6	CALCA, TG
34	pendred syndrome	13.6	TPO, DIO2, TG
35	mucinoses	13.6	TRH, TPO, TSHR, TG
36	endemic goiter	13.5	TRH, TPO, TSHR, TG
37	leydig cell adenoma	13.5	CGA, GNRH1
38	thyroid cancer, follicular	13.5	CALCA, TSHR, TG
39	septooptic dysplasia	13.4	LHX3, GH1, PROP1
40	empty sella syndrome	13.4	LHX3, GH1, PROP1
41	gestational trophoblastic neoplasm	13.4	CGA, CGB7, ALPP, TSHR
42	acth deficiency	13.4	GH1, TRH, PROP1
43	familial medullary thyroid carcinoma	13.4	CALCA, ABP1, TG
44	germinoma	13.4	CGA, CGB7, ALPP
45	paget's disease of bone	13.4	BGLAP, CALCA
46	pituitary hypoplasia	13.4	LHX3, GH1, PROP1
47	nodular goiter	13.4	CALCA, TPO, TSHR, TG
48	thyroid cancer	13.4	CALCA, TPO, TSHR, TG
49	pituitary gland disease	13.4	CGA, GH1
50	hypothalamic disease	13.3	CGA, GNRH1, GH1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 liothyronine, liothyronine sodium, potassium iodide, potassium iodide granules [va product], thyroglobulin

MalaCards organs/tissues related to thyrotoxicosis:

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MGI Mouse Phenotypes related to thyrotoxicosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.1	TG
2	endocrine/exocrine gland phenotype	MP:0005379	9.4	PROP1, TRH, GNRH1, IL2, LHX3
3	renal/urinary system phenotype	MP:0005367	8.8	ADM, NPPA, DIO2, GNRH1, INS
4	digestive/alimentary phenotype	MP:0005381	8.7	LEP, CD36, INS, GNRH1, GHRL, DIO2
5	reproductive system phenotype	MP:0005389	8.6	PROP1, TSHR, HCN2, DIO3, GH1, GNRH1
6	liver/biliary system phenotype	MP:0005370	8.4	ADM, TXNRD2, GH1, IL2, INS, CD36
7	nervous system phenotype	MP:0003631	8.1	TRH, HCN2, TSHR, TG, PROP1, TXNRD2
8	mortality/aging	MP:0010768	7.8	DIO3, HCN2, TSHR, PROP1, ADM, TPO
9	growth/size phenotype	MP:0005378	6.0	TRH, TPO, DIO2, DIO3, HCN2, TSHR
10	homeostasis/metabolism phenotype	MP:0005376	3.9	LHX3, TPO, DIO2, DIO3, TTR, TSHR

Articles related to thyrotoxicosis:

(show top 50)    (show all 53)

id	Title	Authors	Year	Affiliating Genes
1	Thyrotoxicosis due to functioning metastatic follicul ar thyroid carcinoma after twelve I-131 therapies. (19692828)	Tan J.... Liu X.	2009	TG
2	Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis. (19396632)	Nascif S.O.... Lengyel A.M.	2009	GHRL
3	Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism. (18941937)	Strada L.... Del Sette M.	2008	MTHFR
4	Thyrotoxicosis factitia masquerading as recurrent Graves' disease: endogenous antibody immunoassay interference, a pitfall for the unwary. (18482926)	Jahagirdar V.R.... Singh B.M.	2008	TG
5	Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)	Watkins M.G.... Menon R.K.	2008	TSHR
6	Goserelin-induced transient thyrotoxicosis in a hypot hyroid woman on L-thyroxine replacement. (18689910)	van Bon A.C.... Wiersinga W.M.	2008	GNRH1
7	Thyrotoxicosis factitia: role of thyroglobulin. (18583641)	Chow E.... Gama R.	2008	TG
8	Decreased ghrelin-induced GH release in thyrotoxicosis: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH. (17410412)	Nascif S.O.... Lengyel A.M.	2007	GHRL
9	Erythrocyte carbonic anhydrase I and zinc concentrations in thyrotoxicosis reflect integrated thyroid hormone levels over the previous few months (17657991)	Yoshida K.	2007	CA1
10	Thyrotoxicosis after denileukin diftitox therapy in patients with mycosis fungoides. (16595600)	Ghori F.... Duvic M.	2006	IL2
11	Hunger-satiety signals in patients with Graves' thyrotoxicosis before, during, and after long-term pharmacological treatment. (16077172)	RAPjdmark S.... Brismar K.	2005	LEP, GH1
12	Is steroid therapy needed in the treatment of destructive thyrotoxicosis induced by alpha-interferon in chronic hepatitis C? (15860921)	Minelli R.... Delsignore R.	2005	TPO, IFNA1
13	Testicular germ cell tumour presenting as thyrotoxicosis. (15117443)	Tilbrook L.K.... Blainey A.D.	2004	CGA
14	Elevated bone resorption markers in a patient with hy percalcemia associated with post-partum thyrotoxicosis and hypoadrenocorticism due to pituitary failure. (15636435)	Fujikawa M.... Lida M.	2004	CD36
15	Prevalence of germline mutations in the TSH receptor gene as a cause of juvenile thyrotoxicosis. (15384882)	Lavard L.... Parma J.	2004	TSHR
16	The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment. (15125885)	Zimmermann-Belsing T.... Feldt-Rasmussen U.	2004	LEP
17	Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). (12201835)	Blair J.C.... Savage M.O.	2002	TXNRD2
18	Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. (11145561)	Pachucki J.... Larsen P.R.	2001	HCN2, DIO2
19	Prevalence of gestational thyrotoxicosis in Asian women evaluated in the 8th to 14th weeks of pregnancy: correlations with total and free beta human chorionic gonadotrophin. (11589683)	Yeo C.P.... Jacob E.	2001	CGB7
20	The nature of human chorionic gonadotrophin glycoforms in gestational thyrotoxicosis. (11453950)	Talbot J.A.... Robertson W.R.	2001	CGA
21	Clinical features and pathogenesis of thyrotoxicosis in adult Melanesians in Papua New Guinea. (10718822)	Michelangeli V.P.... Colman P.G.	2000	TPO, TSHR, TG
22	Thyrotoxicosis in a male patient associated with excess human chorionic gonadotropin production by germ cell tumor. (10958315)	Goodarzi M.O.... Van Herle A.J.	2000	CGA
23	A Val 677 activating mutation of the thyrotropin receptor in a Hurthle cell thyroid carcinoma associated with thyrotoxicosis. (10037070)	Russo D.... Clark O.H.	1999	TSHR
24	A germline mutation of the thyrotropin receptor gene associated with thyrotoxicosis and mitral valve prolapse in a Chinese family. (10199795)	Khoo D.H.C.... Vassart G.	1999	TSHR
25	Recurrent fetal thyrotoxicosis in a woman with Graves' disease: case report. (10584424)	Ting M.K.... Chen T.C.	1999	TSHR
26	A novel thyrotropin receptor mutation in an infant with severe thyrotoxicosis. (10560955)	Esapa C.T.... Harris P.E.	1999	TSHR
27	Serum cytokines in thyrotoxicosis. (10022397)	Siddiqi A.... Burrin J.M.	1999	IL11
28	Different effects of pyridostigmine on the thyrotropin response to thyrotropin-releasing hormone in endogenous depression and subclinical thyrotoxicosis. (9440477)	Coiro V.... Chiodera P.	1998	TRH
29	Elevation of circulating proadrenomedullin-N terminal 20-peptide in thyrotoxicosis. (9156034)	Taniyama M.... Katagiri T.	1997	ADM
30	Antithyroid therapy improves bony manifestations and bone metabolic markers in patients with Graves' thyrotoxicosis. (9302397)	Nagasaka S.... Saito T.	1997	CD36, SLPI
31	Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)	Tonacchera M.... Ludgate M.	1996	TPO, TG
32	A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study. (8784093)	Refetoff S.... Weiss R.E.	1996	TTR
33	Color flow Doppler sonography in thyrotoxicosis factitia. (8957744)	Bogazzi F.... Martino E.	1996	TG
34	The calcium tolerance test in thyrotoxicosis, Hashimoto's thyroiditis and after total thyroidectomy (8984764)	Blahos J.... Spacek P.	1996	CALCA, BGLAP
35	Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)	Koizumi S.... Iriuda Y.	1995	IFNA1
36	Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis. (8778159)	Cappiello E.... Raggi U.	1995	TG
37	Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms. (8054864)	Walker M.... Kendall-Taylor P.	1994	INS
38	Thyrotoxicosis and hungry bone syndrome--a cause of posttreatment hypocalcemia. (8200118)	Dembinski T.C.... Blandford D.E.	1994	ALPP
39	Differentiation of postpartum thyrotoxicosis by serum thyroglobulin: usefulness of a new multisite immunoradiometric assay. (7833663)	Hidaka Y.... Amino N.	1994	TG
40	Atrial natriuretic peptide and cyclic guanosine monophosphate plasma concentrations in patients with thyrotoxicosis and atrial fibrillation. Effect of short-term methimazole therapy. (8077618)	Czekalski S.... Gruszczynska M.	1994	NPPA
41	Thyrotoxicosis-induced congestive heart failure in an urban hospital. (7985722)	Wilson B.E.... Newmark S.R.	1994	ALB
42	Crucial role of serum human chorionic gonadotropin for the aggravation of thyrotoxicosis in early pregnancy in Graves' disease. (8257857)	Tamaki H.... Amino N.	1993	CGA
43	Is soluble CD25 antigen (interleukin-2 receptor) a useful parameter for differential diagnosis of thyrotoxicosis? (1600337)	HA1fner M.... Heilig B.	1992	IL2RA
44	Transient thyrotoxicosis and persistent hypothyroidism due to acute autoimmune thyroiditis after interleukin-2 and interferon-alpha therapy for metastatic carcinoma: a case report. (1558092)	Sauter N.P.... Lechan R.M.	1992	IFNA1
45	Biogenic amines and thyrotoxicosis. (1595325)	Upadhyaya I.... Udupa K.N.	1992	ABP1
46	Choriogonadotropin-mediated thyrotoxicosis in a man. (2049833)	Cain H.J.... Norman R.J.	1991	CGA
47	Incidence, predictability, and pathogenesis of amioda rone-induced thyrotoxicosis and hypothyroidism. (1951413)	Trip M.D.... Plomp T.A.	1991	TG
48	Erythrocyte sorbitol levels in patients with thyrotoxicosis (2286282)	Hosojima H.... Morimoto S.	1990	SDHB, SORD
49	Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. (2315685)	Wilson R.... Thomson J.A.	1990	TSHR
50	Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)	Ruiz M.... Ingbar S.H.	1982	ALB

Genes related to thyrotoxicosis according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	TSHR	thyroid stimulating hormone receptor	11.0	Publications
2	DIO3	deiodinase, iodothyronine, type III	11.0
3	TXNRD2	thioredoxin reductase 2	11.0	Publications
4	TRH	thyrotropin-releasing hormone	11.0	Publications
5	TG	thyroglobulin	11.0	Publications
6	DIO2	deiodinase, iodothyronine, type II	11.0	Publications
7	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
8	LHX3	LIM homeobox 3	11.0
9	LMOD1	leiomodin 1 (smooth muscle)	11.0	Publications
10	HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	11.0	Publications
11	PROP1	PROP paired-like homeobox 1	11.0
12	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
13	CA1	carbonic anhydrase I	11.0	Publications
14	SORD	sorbitol dehydrogenase	11.0	Publications
15	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
16	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
17	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
18	TPO	thyroid peroxidase	11.0	Publications
19	IL11	interleukin 11	11.0	Publications
20	ADM	adrenomedullin	11.0	Publications
21	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
22	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
23	TTR	transthyretin	11.0	Publications
24	ALPP	alkaline phosphatase, placental	11.0	Publications
25	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
26	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
27	IFNA1	interferon, alpha 1	11.0	Publications
28	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
29	GH1	growth hormone 1	11.0	Publications
30	LEP	leptin	11.0	Publications
31	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
32	NPPA	natriuretic peptide A	11.0	Publications
33	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
34	IL2	interleukin 2	11.0	Publications
35	ALB	albumin	11.0	Publications
36	INS	insulin	11.0	Publications

Pathways related to thyrotoxicosis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Regulation of thyroid hormone activity38	9.9	DIO2, DIO3
2	Hematopoietic cell lineage20	9.4	TPO, IL2RA, IL11, CD36
3	Autoimmune thyroid disease20	9.1	CGA, IL2, IFNA1, TPO, TSHR, TG
4	eIF2 Pathway36	8.2	GH1, GNRH1, IL2RA, IL2, INS
5	p70S6K Signaling36	8.2	GNRH1, IL2RA, IL2, INS, GH1
6	JAK-STAT Pathway36	8.2	GH1, GNRH1, IFNA1, IL2RA, IL2, IL11
7	Jak-STAT signaling pathway20	8.1	TPO, GH1, IFNA1, IL2RA, IL2, IL11
8	Cytokine-cytokine receptor interaction20	8.0	TPO, GH1, IFNA1, IL2RA, IL2, IL11

Compounds related to thyrotoxicosis according to GeneDecks:

(show top 50)    (show all 258)

id	Compound	Score	Top Affiliating Genes
1	estradiol32 9 18 9	12.8	TSHR, SLPI, DIO3, TRH, IL11, CGB7
2	propylthiouracil32 9 9	11.8	TG, TSHR, DIO3, DIO2, TPO, ALPP
3	125i32	9.8	LMOD1, DIO2, DIO3, TSHR, TG, ADM
4	iodine32 18	10.7	TSHR, TRH, LMOD1, TPO, DIO2, TG
5	glucose32	9.6	TRH, DIO2, SORD, IL11
6	methimazole32 9 9	11.4	ALPP, IL2RA, DIO2, TSHR, BGLAP, TRH
7	deoxypyridinoline32	9.4	IL11, BGLAP, GH1, CD36, ALPP
8	25-hydroxyvitamin d32	9.3	BGLAP, LEP, IL2RA, ALPP, SLPI
9	etidronate32	9.3	SLPI, BGLAP, CD36, ALPP, GNRH1, CALCA
10	aspartate32	9.2	GNRH1, IL11, CGA, SDHB, GH1, TXNRD2
11	gnrh32	8.9	PROP1, TRH, GHRL, GH1, INS, CGB7
12	alendronate32 9 9	10.8	IL11, SLPI, CD36, ALPP, CALCA, GH1
13	mannitol32 9 9	10.7	GH1, SDHB, CGA, GHRL, ADM, SLPI
14	pyridinoline32	8.7	CD36, ALPP, CALCA, GH1, BGLAP, SLPI
15	zoledronic acid32	8.6	SLPI, CALCA, GNRH1, ALPP, IL2, CD36
16	triiodothyronine32	8.5	TG, TSHR, LMOD1, LEP, CGA, TTR
17	naloxone32 34 9 9	11.5	LEP, CGA, IL2, GNRH1, GH1, GHRL
18	ascorbic acid32 18	9.5	CD36, IL2RA, ALPP, TPO, TTR, TG
19	glutamate32	8.4	SORD, CALCA, GNRH1, ALPP, INS, SDHB
20	heparin32 9 18 9	11.3	BGLAP, CGA, ALPP, GNRH1, ABP1, SLPI
21	epinephrine32 9 18 9	11.1	NPPA, TG, TTR, GHRL, GNRH1, IL11
22	acetylcholine32 9 18 9	10.8	GH1, GHRL, GNRH1, TPO, TG, CGA
23	dopamine32 9 18 9	10.6	GH1, LMOD1, SDHB, MTHFR, CGA, IL11
24	paraffin32	7.6	GHRL, TTR, GH1, LEP, BGLAP, IL2RA
25	vegf32	7.6	CALCA, GH1, GHRL, TSHR, TG, NPPA
26	acth32	7.5	TRH, GHRL, GH1, CALCA, GNRH1, IL11
27	creatinine32	7.4	LEP, ABP1, TPO, GHRL, GH1, IL2RA
28	cysteine32	7.4	IL11, MTHFR, LHX3, SDHB, BGLAP, LMOD1
29	h2o232	7.3	SDHB, LEP, ABP1, TXNRD2, CD36, IL2RA
30	prednisolone32 9 9	9.3	GH1, BGLAP, TSHR, IL2RA, TG, ALPP
31	cycloheximide32	7.3	CGA, CD36, IL11, IL2, IFNA1, TRH
32	testosterone32 9 18 9	10.2	MTHFR, SDHB, BGLAP, CGB7, SLPI, SORD
33	hydrocortisone32 9 9	9.2	GHRL, TRH, TPO, TG, SLPI, ADM
34	thymidine32 18	8.1	TXNRD2, TG, SLPI, ADM, TRH, GHRL
35	retinoic acid32 42 18	9.1	TTR, ADM, BGLAP, MTHFR, CGB7, CD36
36	cisplatin32 34 9 9	10.0	CGA, CGB7, IL2, MTHFR, IL2RA, IFNA1
37	alanine32	6.9	SLPI, TSHR, TTR, DIO2, TXNRD2, ALPP
38	histamine32 18	7.9	SLPI, BGLAP, GHRL, CALCA, ALB, IL2RA
39	calcitriol32 42 9 18 9	10.9	ALPP, SLPI, TG, GH1, BGLAP, CD36
40	indomethacin32 9 9	8.7	GH1, ADM, CALCA, IL2, CA1, ALB
41	cholesterol32 9 18 9	9.7	SDHB, TSHR, TTR, ABP1, ALPP, TPO
42	lactate32	6.6	SDHB, CGA, CGB7, INS, ALB, ADM
43	vitamin d32	6.6	GH1, CALCA, ALPP, IL2RA, CGA, BGLAP
44	norepinephrine32 9 18 9	9.2	LEP, ADM, SLPI, NPPA, TG, TTR
45	thyroxine32 18	7.0	BGLAP, LEP, GH1, CALCA, GNRH1, ALPP
46	arginine32	5.9	BGLAP, SDHB, LEP, CGA, INS, IL2RA
47	cyclosporin a32 42	6.8	BGLAP, SDHB, LEP, MTHFR, CGA, SLPI
48	serine32	5.7	IL2, TXNRD2, TTR, GH1, ALPP, IFNA1
49	dexamethasone32 42 34 9 9	9.6	LMOD1, GHRL, GH1, GNRH1, ALPP, IFNA1
50	estrogen32	4.9	ALPP, IL2RA, IL11, INS, CD36, CGA

Cellular components related to thyrotoxicosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	5.5	BGLAP, ADM, SORD, TTR, ABP1, GHRL
2	extracellular region	GO:005576	5.0	GH1, GHRL, TRH, TTR, TG, NPPA

Biological processes related to thyrotoxicosis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	10.2	TG, DIO3, DIO2, TPO
2	thyroid hormone generation	GO:006590	10.1	DIO3, DIO2, TPO, CGA
3	response to cold	GO:009409	9.9	ADM, DIO2, TRH
4	positive regulation of multicellular organism growth	GO:040018	9.9	GH1, GHRL, TSHR
5	positive regulation of vasodilation	GO:045909	9.6	ADM, CALCA, INS
6	female pregnancy	GO:007565	9.3	ADM, NPPA, GNRH1, LEP
7	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	GH1, IL11, INS, CD36
8	positive regulation of MAPK cascade	GO:043410	9.3	LEP, CD36, INS, IL11
9	glucose metabolic process	GO:006006	9.2	LEP, INS, GHRL, SORD
10	elevation of cytosolic calcium ion concentration	GO:007204	8.8	ADM, GHRL, CALCA, IL2
11	positive regulation of cell proliferation	GO:008284	8.5	ADM, TSHR, IL2, IL11, INS, CGA
12	negative regulation of apoptotic process	GO:043066	8.4	PROP1, GHRL, ALB, INS, LEP, LHX3
13	cell-cell signaling	GO:007267	8.1	CGA, ADM, TSHR, HCN2, TRH, CALCA
14	small molecule metabolic process	GO:044281	7.5	CA1, TPO, DIO2, DIO3, ALB, INS

Molecular functions related to thyrotoxicosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	thyroxine 5-deiodinase activity	GO:004800	10.2	DIO2, DIO3
2	hormone activity	GO:005179	7.2	LEP, ADM, NPPA, TG, TTR, GH1