MCID: THY033
MIFTS: 58

Thyrotoxicosis malady

Endocrine diseases category
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Summaries for Thyrotoxicosis

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Wikipedia:65 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

MalaCards based summary: Thyrotoxicosis is related to neonatal thyrotoxicosis and thyroiditis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are G alpha (s) signalling events and Hormone ligand-binding receptors. The drugs thyroglobulin and thyroid (usp) and the compounds sodium iodide and asparagine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and bone, and related mouse phenotypes are hearing/vestibular/ear and reproductive system.

Disease Ontology:8 A thyroid gland disease that is characterized by excess thyroid hormone.

Description from OMIM:46 275000

Aliases & Classifications for Thyrotoxicosis

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Related Diseases for Thyrotoxicosis

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Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal thyrotoxicosis31.6TSHR, LHX3
2thyroiditis31.4CGA, TSHR, TG
3hypothyroidism31.0TG, TSHR
4myxedema30.8TG, TSHR
5subacute thyroiditis30.8TSHR, TG
6multinodular goiter30.7TSHR, TG
7endemic goiter30.6TG, TSHR
8follicular thyroid carcinoma30.5TSHR, TG
9nodular goiter30.5TSHR, TG
10graves' disease30.4TG, TSHR, DIO2, CGA
11goiter30.4TXNRD2, TG, TSHR, DIO2
12toxic diffuse goiter30.4TSHR, TG
13hypopituitarism30.4LHX3, CGA
14struma ovarii30.3TSHR, TG
15autoimmune thyroiditis30.3TSHR, TG
16nontoxic goiter30.1TG, TSHR
17hyperthyroidism30.1CGA, DIO2, TSHR, TG, TXNRD2
18papillary thyroid carcinoma30.1TG, TSHR
19papillary carcinoma29.9TSHR, TG
20infertility29.8CGA, TXNRD2
21thyroid adenoma29.7TXNRD2, TG, TSHR, DIO2
22adenoma29.6TXNRD2, TG, TSHR, DIO2, CGA
23pendred syndrome10.4TG
24suppurative thyroiditis10.3
25hypertension10.3
26exophthalmos10.3
27hepatitis10.3
28hypokalemic periodic paralysis10.3
29thymic hyperplasia10.3
30thyroid cancer10.2
31thyroid agenesis10.2TG, TSHR
32precocious puberty10.2TSHR, CGA
33thyroid hormone resistance syndrome10.2TXNRD2, TG
34pulmonary hypertension10.2
35cerebritis10.2
36congenital hypothyroidism10.2TG, TSHR
37gestational trophoblastic neoplasm10.2CGA, TSHR
38kallmann syndrome10.2LHX3, CGA
39thyroid cancer, anaplastic10.2TSHR, TG
40myocardial infarction10.1
41pernicious anemia10.1
42exophthalmic ophthalmoplegia10.1
43ophthalmoplegia10.1
44thyrotoxic periodic paralysis10.1
45thyroid carcinoma with thyrotoxicosis10.1
46venous thrombosis10.1
47turner syndrome10.1CGA, TG
48pregnancy loss10.1CGA, TG
49teratoma10.1TG, CGA
50congestive heart failure10.1

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Symptoms for Thyrotoxicosis

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Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

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Genetic Tests for Thyrotoxicosis

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Anatomical Context for Thyrotoxicosis

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MalaCards organs/tissues related to Thyrotoxicosis:

32
Thyroid, Heart, Bone, Pituitary, Testes, Liver, Brain, Bone marrow

Animal Models for Thyrotoxicosis or affiliated genes

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MGI Mouse Phenotypes related to Thyrotoxicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6HCN2, LHX3, TSHR
2MP:00053898.3CGA, TSHR, LHX3, HCN2
3MP:00053798.1LHX3, TG, TSHR, DIO2, CGA
4MP:00036317.5CGA, TSHR, TG, TXNRD2, LHX3, HCN2
5MP:00053767.5LHX3, TXNRD2, TG, TSHR, DIO2, CGA
6MP:00053787.2HCN2, LHX3, TG, TSHR, DIO2, CGA

Publications for Thyrotoxicosis

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Articles related to Thyrotoxicosis:

(show top 50)    (show all 694)
idTitleAuthorsYear
1
A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy. (25150234)
2014
2
Management of severe amiodarone-induced thyrotoxicosis after failure of standard medical treatment. (23540613)
2013
3
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
4
Increased sex hormone-binding globulin levels in children and adolescents with thyrotoxicosis. (23548728)
2013
5
Body mass index and the development of amiodarone-induced thyrotoxicosis in adults with congenital heart disease--a cohort study. (22386642)
2013
6
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
7
Gynaecomastia as the initial presentation of thyrotoxicosis. (23565425)
2012
8
Total thyroidectomy for amiodarone-associated thyrotoxicosis: should surgery always be delayed for pre-operative medical preparation? (22613770)
2012
9
Thyrotoxicosis presenting as acute bulbar palsy. (21751598)
2011
10
Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis. (20551140)
2011
11
The association of insulin resistance with subclinical thyrotoxicosis. (21834678)
2011
12
Resistant thyrotoxicosis in a patient with graves disease: a case report. (21845211)
2011
13
Thyrotoxicosis. (21819001)
2011
14
Takotsubo cardiomyopathy precipitated by thyrotoxicosis. (21054211)
2010
15
Repetitive monomorphic ventricular tachycardia as a manifestation of suboptimally treated thyrotoxicosis. (22022738)
2010
16
Thyrotoxicosis factitia induces Takotsubo cardiomyopathy in end-stage renal disease: a pathogenetic hypothesis. (20150943)
2010
17
The correlation between left ventricular failure and right ventricular systolic dysfunction occurring in thyrotoxicosis. (20589198)
2010
18
A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. (19628289)
2010
19
Iodinated contrast prior to evaluation for thyrotoxicosis. (19263484)
2009
20
A Case of Amiodarone-Induced Thyrotoxicosis: A diagnostic and therapeutic dilemma. (21509317)
2009
21
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
22
Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism. (18941937)
2008
23
Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004. (18602654)
2008
24
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
25
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
26
Impact of thyroid metabolism on the course of INR levels in a patient with systemic anticoagulation suffering from amiodarone-induced thyrotoxicosis. (17943696)
2007
27
Tailor treatment to the patient in thyrotoxicosis. (17784663)
2007
28
Thyrotoxicosis with coronary spasm that required coronary artery bypass surgery. (18057764)
2007
29
Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome. (17572251)
2007
30
Management of amiodarone-induced thyrotoxicosis in Latin America: an electronic survey. (16984234)
2006
31
Cardiomyopathy and thyrotoxicosis: tachycardiomyopathy or thyrotoxic cardiomyopathy? (16485742)
2006
32
A cluster of thyrotoxicosis associated with consumption of a soy milk product. (16366059)
2005
33
Secondary osteoporosis: thyrotoxicosis, rheumatoid arthritis, and diabetes mellitus. (15221485)
2004
34
Contrast-induced thyrotoxicosis. (15332308)
2004
35
Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum--report of two cases. (15763786)
2004
36
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
37
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
38
Thyrotoxicosis--surgical management in the era of evidence-based medicine: experience in western India with 752 cases. (12471001)
2002
39
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
40
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
41
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
42
Thyrotoxicosis and hungry bone syndrome--a cause of posttreatment hypocalcemia. (8200118)
1994
43
Thyrotoxicosis presenting as generalized pruritic exfoliative dermatitis and fever. (1386765)
1992
44
Choriogonadotropin-mediated thyrotoxicosis in a man. (2049833)
1991
45
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
46
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
47
Concomitant pernicious anemia and thyrotoxicosis. A case report and discussion. (5409998)
1970
48
Thyrotoxicosis and gigantism associated with "Klinefelter's syndrome". (5850468)
1965
49
Neonatal thyrotoxicosis. (13731873)
1960
50
Uropepsin excretion in neurocirculatory asthenia and thyrotoxicosis. (13381999)
1956

Variations for Thyrotoxicosis

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Expression for genes affiliated with Thyrotoxicosis

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Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

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Compounds for genes affiliated with Thyrotoxicosis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB
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Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1sodium iodide449.9TSHR, TG
2asparagine449.8TXNRD2, TSHR
3cytosine44 2410.8TSHR, TXNRD2
4prednisolone44 28 1111.7TSHR, TG
5selenocysteine44 24 1111.7DIO2, TXNRD2
6carbohydrates449.6TSHR, TG
7adenine44 24 1111.5TSHR, TXNRD2
8guanine44 24 1111.5TXNRD2, TG, TSHR
9sialic acid449.4CGA, TSHR, TG
10thymidine44 2410.4TSHR, TG, TXNRD2
11paraffin449.4TG, TSHR, CGA
12propylthiouracil44 2 1111.4TG, TSHR, DIO2
13iodine44 2410.4DIO2, TSHR, TG
14125i449.4DIO2, TSHR, TG
15iodide44 2410.4TG, TSHR, DIO2
16methimazole44 2 1111.4DIO2, TSHR, TG
17adenylate449.3CGA, TSHR, TG
18forskolin44 50 1111.3CGA, DIO2, TSHR
19selenium44 2410.3DIO2, TG, TXNRD2
20h2o2449.2CGA, TG, TXNRD2
21vegf449.2TG, TSHR, CGA
22carbachol44 28 1111.1CGA, TG
23threonine449.1DIO2, TSHR, TXNRD2
24glutamate449.1TG, TSHR, CGA
25cycloheximide449.0CGA, DIO2, TG
26sodium44 2410.0HCN2, TG, TSHR
27cyclic amp44 2410.0HCN2, TSHR, CGA
28aspartate449.0TXNRD2, TG, TSHR, CGA
29arginine448.9CGA, TSHR, TG, TXNRD2
30retinoic acid44 249.8DIO2, TSHR, TG, TXNRD2
31ribonucleic acid448.8TG, TSHR, DIO2, CGA
32tyrosine448.4LHX3, TXNRD2, TG, TSHR, DIO2
33triiodothyronine448.4CGA, DIO2, TSHR, TG, TXNRD2
34thyroxine44 249.4TXNRD2, TG, TSHR, DIO2, CGA
35alanine448.4CGA, DIO2, TSHR, TG, TXNRD2
36estrogen448.4TXNRD2, TG, TSHR, DIO2, CGA
37serine448.3TXNRD2, TG, TSHR, DIO2, CGA
38cysteine447.7DIO2, TSHR, TG, TXNRD2, LHX3, HCN2

GO Terms for genes affiliated with Thyrotoxicosis

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Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.2DIO2, TG
2thyroid gland developmentGO:0308789.1TG, CGA
3thyroid hormone generationGO:0065908.8CGA, DIO2, TG
4cell-cell signalingGO:0072678.8CGA, TSHR, HCN2

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4CGA, TG

Products for genes affiliated with Thyrotoxicosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Thyrotoxicosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet