MCID: THY033
MIFTS: 58

Thyrotoxicosis malady

Endocrine diseases category

Summaries for Thyrotoxicosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

MalaCards: Thyrotoxicosis is related to thyroiditis and neonatal thyrotoxicosis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Regulation of thyroid hormone activity. The drugs potassium iodide and thyroglobulin and the compounds cycloheximide and forskolin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are endocrine/exocrine gland and growth/size.

Description from OMIM:46 275000

Aliases & Classifications for Thyrotoxicosis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 25ICD10
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Related Diseases for Thyrotoxicosis

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17GeneCards, 18GeneDecks
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Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3CGA, TRH, SERPINA7, TSHR, TPO, TG
2neonatal thyrotoxicosis31.0LHX3, TSHR
3graves' disease30.7DIO2, CGA, LMOD1, SERPINA7, TSHR, TPO
4hyperthyroidism30.6TXNRD2, CA1, DIO2, CGA, TRH, LMOD1
5goiter30.6TRH, LMOD1, SERPINA7, TSHR, TPO, TG
6hypothyroidism30.6TRH, TSHR, TPO, TG
7hypertension30.4ADM
8myxedema30.3TSHR, TPO, TG
9exophthalmos30.3TRH, TSHR
10subacute thyroiditis30.3TG
11hepatitis30.3SERPINA7, SORD
12multinodular goiter30.3TG, TPO, TSHR
13thyroid cancer30.2TXNRD2, DIO2, TRH, TSHR, TPO, TG
14endemic goiter30.1TSHR, TPO, TG
15pernicious anemia30.1TPO, TG
16follicular thyroid carcinoma30.1TG, TSHR
17adenoma30.1TSHR, TPO, TG, LMOD1, TRH, PROP1
18diabetes insipidus30.0TRH
19diabetes mellitus30.0SORD
20autoimmune thyroiditis30.0TPO, TG
21nodular goiter30.0TSHR, TPO, TG
22hypopituitarism30.0LHX3, CGA, PROP1, TRH
23hyperthyroxinemia30.0TRH, SERPINA7, TSHR, TPO
24choriocarcinoma30.0ADM, CGB7, CGA, DIO3
25struma ovarii29.9TG, TSHR
26toxic diffuse goiter29.9TSHR, TPO, TG
27papillary thyroid carcinoma29.9TSHR, TPO, TG
28addison's disease29.9TG, TPO
29papillary carcinoma29.9TSHR, TPO, TG
30cushing's syndrome29.7TRH
31endogenous depression29.7TRH
32nontoxic goiter29.7TG, TPO, TSHR
33hypogonadism29.7TRH, PROP1, CGA
34thyroid hormone resistance syndrome29.7TG, SERPINA7, TRH, TXNRD2
35infertility29.7TXNRD2, CGA, IL11, TPO
36tuberculosis29.7TPO, IL11
37acute thyroiditis10.3
38suppurative thyroiditis10.3
39hypokalemic periodic paralysis10.3
40cerebritis10.1
41exophthalmic ophthalmoplegia10.1
42hepatitis c10.1
43myocardial infarction10.1
44ophthalmoplegia10.1
45periarthritis10.0
46pituitary apoplexy10.0
47hypercalcemia10.0
48sick sinus syndrome10.0
49hepatitis a10.0
50congestive heart failure10.0

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Clinical Features for Thyrotoxicosis

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46OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Thyrotoxicosis

Drug clinical trials:

Search ClinicalTrials for Thyrotoxicosis

Search NIH Clinical Center for Thyrotoxicosis

Search CenterWatch for Thyrotoxicosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thyrotoxicosis

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Anatomical Context for Thyrotoxicosis

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32MalaCards
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MalaCards organs/tissues related to Thyrotoxicosis:

32
Thyroid, Heart, Pituitary, Bone, Testes, Liver, Brain, Bone marrow

Animal Models for Thyrotoxicosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Thyrotoxicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7PROP1, TG, TPO, TSHR, LHX3, TRH
2MP:00053789.0TG, DIO2, TPO, TSHR, HCN2, TRH
3MP:00053768.7TXNRD2, TG, TPO, ADM, TSHR, SLPI

Publications for Thyrotoxicosis

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50PubMed
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Articles related to Thyrotoxicosis:

(show top 50)    (show all 680)
idTitleAuthorsYear
1
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
2
Amiodarone-induced thyrotoxicosis with paroxysmal supraventricular (ectopic atrial) tachycardia: case report and review of the literature. (23671452)
2013
3
Bilateral gynecomastia: A rare presentation of thyrotoxicosis. (23776925)
2013
4
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
5
Complete heart block in thyrotoxicosis, is it a manifestation of thyroid storm? A case report and review of the literature. (22934200)
2012
6
The skeletal consequences of thyrotoxicosis. (22454529)
2012
7
The association of insulin resistance with subclinical thyrotoxicosis. (21834678)
2011
8
Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. (21510801)
2011
9
Subclinical thyrotoxicosis in an outpatient population - predictors of outcome. (21044113)
2011
10
Severe transient left ventricular dysfunction induced by thyrotoxicosis. (21538165)
2011
11
The American Thyroid Association and American Association of Clinical Endocrinologists hyperthyroidism and other causes of thyrotoxicosis guidelines: viewpoints from Japan and Korea. (21663418)
2011
12
Congestive heart failure in subjects with thyrotoxicosis in a black community. (20730063)
2010
13
Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients. (20513982)
2010
14
Preservation of echogenicity in type II amiodarone-induced thyrotoxicosis: possible histopathological basis. (21051580)
2010
15
Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients. (20208398)
2010
16
Radiation exposure levels in family members of omani patients with thyrotoxicosis treated with radioiodine (I) as outpatients. (21509291)
2009
17
Preoperative therapeutic plasma exchange in patients with thyrotoxicosis. (19484727)
2009
18
Thyrotoxicosis and low iodine uptake in a woman with graves' disease. (22974457)
2008
19
Concurrent Graves disease thyrotoxicosis and myasthenia gravis: the treatment of the former may dangerously reveal the latter. (18518867)
2008
20
Fatal outcome during anaesthesia induction in a patient with amiodarone-induced thyrotoxicosis. (18334037)
2008
21
Thyrotoxicosis with hypokalaemic paralysis and hyperlactataemia. (17270102)
2007
22
Ablative thyroid treatment for thyrotoxicosis due to thyrotropin-producing pituitary tumours. (17172570)
2007
23
Release criteria from hospitals of 131I thyrotoxicosis therapy patients in developing countries--case study. (16464838)
2006
24
Hemorrhage into a thyroid nodule as a cause of thyrotoxicosis. (16772204)
2006
25
A cluster of thyrotoxicosis associated with consumption of a soy milk product. (16366059)
2005
26
Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases. (15833889)
2005
27
Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum--report of two cases. (15763786)
2004
28
Can amiodarone be restarted after amiodarone-induced thyrotoxicosis? (15068630)
2004
29
The 'Dead-Sea thyrotoxicosis': a side-effect of the Dead-Sea climatotherapy? (12948932)
2003
30
Thyrotoxicosis. (12617406)
2003
31
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. (14695499)
2003
32
Amiodarone-induced thyrotoxicosis. (12512204)
2002
33
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. (11145561)
2001
34
Periodic hypokalemic paralysis disclosing thyrotoxicosis]. (9793040)
1998
35
The syndrome of resistance to thyroid hormone, misdiagnosed and treated as thyrotoxicosis. (15251715)
1998
36
Patient with monoclonal gammopathy, thyrotoxicosis, pretibial myxedema and thyroid-associated ophthalmopathy; demonstration of direct binding of autoantibodies to the thyrotropin receptor. (8590966)
1996
37
The calcium tolerance test in thyrotoxicosis, Hashimoto's thyroiditis and after total thyroidectomy]. (8984764)
1996
38
Thyrotoxicosis-induced congestive heart failure in an urban hospital. (7985722)
1994
39
Is soluble CD25 antigen (interleukin-2 receptor) a useful parameter for differential diagnosis of thyrotoxicosis? (1600337)
1992
40
Plasma exchange and hemoperfusion in iodine-induced thyrotoxicosis. (1801858)
1991
41
Incidence, predictability, and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism. (1951413)
1991
42
Acute calcific periarthritis of the hip associated with thyrotoxicosis. (3730742)
1986
43
The CT detection of thymic hyperplasia in association with thyrotoxicosis: case report. (6641206)
1983
44
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. (7400892)
1980
45
Neonatal thyrotoxicosis associated with maternal hypothyroidism. (4159675)
1966
46
AN ORAL TYROSINE TOLERANCE TEST IN THYROTOXICOSIS AND MYXEDEMA. (14284982)
1965
47
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder. (5846829)
1965
48
Neonatal thyrotoxicosis. (13731873)
1960
49
Periarthritis of the shoulder associated with thyrotoxicosis. A report of five cases. (14428615)
1959
50
Neonatal thyrotoxicosis. (13667336)
1959

Genetic Variations for Thyrotoxicosis

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Expression for genes affiliated with Thyrotoxicosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Thyrotoxicosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.2TPO, DIO2
3
Hide members
10.1TSHR, TPO, TG
410.1DIO2, DIO3, TXNRD2
510.1DIO2, DIO3, TXNRD2

Compounds for genes affiliated with Thyrotoxicosis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6TRH, DIO2
2forskolin44 49 1112.5IL11, TSHR, ADM
3sodium iodide4410.4TSHR, TPO, TG
43,3-diiodothyronine4410.4DIO3, LMOD1, DIO2
5Liothyronine11 2411.3DIO2, TPO, SERPINA7
6amiodarone44 49 28 1113.3TG, TPO, SERPINA7, LMOD1
7selenium44 2411.3TG, DIO2, TPO, TXNRD2
8selenocysteine44 11 2412.3LMOD1, TXNRD2, DIO3, DIO2
9methimazole44 2 1112.2SERPINA7, TSHR, DIO2, TPO, TG, TRH
10n-bromoacetyl-3,3,5-triiodo-l-thyronine4410.2DIO2, LMOD1
11propylthiouracil44 2 1112.2TSHR, TPO, LMOD1, DIO2, DIO3, TG
12dithiothreitol4410.1TRH, DIO2, TPO, DIO3, LMOD1
13iodotyrosine44 2411.1TPO, TG
14asparagine4410.1TPO, TSHR, TXNRD2, SERPINA7
15hydrocortisone44 2 59 1113.1TRH, SLPI, ADM, TPO, TG
16serine4410.1TSHR, CGA, DIO2, TXNRD2, PROP1
17gnrh4410.1LHX3, CGA, CGB7, PROP1, TRH
18carbachol44 28 1112.1CGA, SLPI, IL11, ADM, TG
19acetylcholine44 49 28 11 2414.1TPO, ADM, TRH
20iodine44 2411.0TG, TPO, LMOD1, TSHR, SERPINA7, TRH
21iodide44 2411.0LMOD1, TG, TPO, SERPINA7, DIO3, DIO2
22ribonucleic acid4410.0IL11, TG, TPO, TSHR, CGA, SERPINA7
23acth4410.0ADM, TSHR, TRH, SERPINA7, IL11, PROP1
24dexamethasone44 49 28 1113.0TRH, DIO3, SLPI, LMOD1, DIO2
25norepinephrine44 11 2412.0ADM, TG, TRH, CGA, CA1, SLPI
26thymidine44 2410.9TRH, IL11, SLPI, TXNRD2, TG, ADM
27125i449.9ADM, TPO, TSHR, TG, DIO3, DIO2
28hydrogen44 2410.9TXNRD2, TSHR, TRH, SORD, TPO, CA1
29creatinine449.9CGA, SLPI, SORD, ADM, TPO, TG
30progesterone44 59 28 11 2413.9SERPINA7, ADM, TSHR, IL11, TRH, CGB7
31lactate449.9SLPI, ADM, CGB7, TG, CGA, SORD
32cyclic amp44 2410.9CGA, SLPI, TSHR, TRH, HCN2, IL11
33sodium44 2410.9HCN2, SLPI, TSHR, TPO, TG, ADM
34dopamine44 28 11 2412.8IL11, SERPINA7, LMOD1, TRH, CGA, DIO2
35steroid449.8SLPI, IL11, PROP1, CGA, TXNRD2, TPO
36adenylate449.8TRH, CGA, TG, TSHR, ADM, TPO
37arginine449.8SERPINA7, TRH, CGA, TXNRD2, CA1, TSHR
38estradiol44 11 2411.8TSHR, SERPINA7, IL11, TRH, CGB7, CGA
39oligonucleotide449.7TPO, TRH, IL11, TSHR, SLPI, SORD
40aspartate449.7IL11, SORD, TXNRD2, TSHR, TPO, CGA
41retinoic acid44 2410.7DIO2, TXNRD2, CGB7, IL11, SLPI, TPO
42triiodothyronine449.7DIO2, TXNRD2, DIO3, CGA, TRH, LMOD1
43glucose449.7SLPI, SORD, DIO2, TRH, IL11, SERPINA7
44mannitol44 1110.6ADM, SLPI, CGA, SORD
45testosterone44 59 11 2412.5TPO, SORD, CGA, CGB7, PROP1, SLPI
46thyroxine44 2410.5TG, TPO, TSHR, SERPINA7, TRH, CGB7
47alanine449.5TG, ADM, TSHR, SERPINA7, SLPI, CGA
48estrogen449.4CGA, TG, ADM, TSHR, SLPI, LMOD1
49tyrosine449.3LHX3, DIO2, TRH, IL11, LMOD1, SERPINA7
50cysteine449.2HCN2, IL11, TG, LMOD1, DIO3, ADM

GO Terms for genes affiliated with Thyrotoxicosis

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16Gene Ontology
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Cellular components related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3TG, ADM, SERPINA7, SLPI, IL11, PCDHA1

Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.2TG, CGA
2hormone biosynthetic processGO:04244610.0TG, TPO, DIO2, DIO3
3thyroid hormone generationGO:0065909.9TG, TPO, CGA, DIO2, DIO3
4response to corticosterone stimulusGO:0514129.9SERPINA7, TRH
5cell-cell signalingGO:0072679.6CGA, TRH, HCN2, IL11, TSHR, ADM

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.1TG, ADM, CGA
2thyroxine 5-deiodinase activityGO:0048009.9DIO2, DIO3

Products for genes affiliated with Thyrotoxicosis

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Sources for Thyrotoxicosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet