MCID: THY033
MIFTS: 57

Thyrotoxicosis malady

Endocrine diseases category
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Summaries for Thyrotoxicosis

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Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Hyperthyroidism, often called overactive thyroid and sometimes hyperthyreosis, is a condition in which... more...

MalaCards: Thyrotoxicosis is related to thyroiditis and neonatal thyrotoxicosis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are G alpha (s) signalling events and Hormone ligand-binding receptors. The drugs thyroglobulin and thyroid (usp) and the compounds sodium iodide and asparagine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hearing/vestibular/ear and reproductive system.

Disease Ontology:8 A thyroid gland disease that is characterized by excess thyroid hormone.

Description from OMIM:47 275000

Aliases & Classifications for Thyrotoxicosis

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 47OMIM, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Thyrotoxicosis

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17GeneCards, 18GeneDecks
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Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3TG, TSHR, CGA
2neonatal thyrotoxicosis31.2LHX3, TSHR
3hypothyroidism30.7TG, TSHR
4graves' disease30.7CGA, TSHR, DIO2, TG
5goiter30.6DIO2, TSHR, TG, TXNRD2
6hyperthyroidism30.6TXNRD2, TG, TSHR, DIO2, CGA
7myxedema30.5TSHR, TG
8subacute thyroiditis30.5TSHR, TG
9multinodular goiter30.4TSHR, TG
10thyroid cancer30.3TSHR, TG, TXNRD2
11endemic goiter30.3TG, TSHR
12nodular goiter30.2TG, TSHR
13hypopituitarism30.2LHX3, CGA
14autoimmune thyroiditis30.2TG, TSHR
15toxic diffuse goiter30.1TG, TSHR
16struma ovarii30.1TG, TSHR
17follicular thyroid carcinoma30.1TG, TSHR
18adenoma30.0TXNRD2, TG, TSHR, DIO2, CGA
19thyroid adenoma29.9TSHR, DIO2, TG, TXNRD2
20nontoxic goiter29.8TG, TSHR
21papillary thyroid carcinoma29.8TSHR, TG
22papillary carcinoma29.8TG, TSHR
23infertility29.7TXNRD2, CGA
24suppurative thyroiditis10.3
25hypertension10.3
26exophthalmos10.3
27hypokalemic periodic paralysis10.3
28hepatitis10.3
29thymic hyperplasia10.3
30cerebritis10.2
31pernicious anemia10.1
32exophthalmic ophthalmoplegia10.1
33myocardial infarction10.1
34ophthalmoplegia10.1
35thyrotoxic periodic paralysis10.1
36venous thrombosis10.1
37pendred syndrome10.1TG
38hepatitis c10.1
39periarthritis10.1
40hyperthyroxinemia10.1
41pituitary apoplexy10.1
42diabetes insipidus10.1
43hypercalcemia10.1
44sick sinus syndrome10.1
45choriocarcinoma10.1
46congenital heart disease10.1
47congestive heart failure10.1
48diabetes mellitus10.1
49myasthenia gravis10.1
50chorea10.1

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Symptoms for Thyrotoxicosis

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47OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Thyrotoxicosis

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Anatomical Context for Thyrotoxicosis

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33MalaCards
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MalaCards organs/tissues related to Thyrotoxicosis:

33
Thyroid, Heart, Pituitary, Bone, Testes, Liver, Brain, Bone marrow

Animal Models for Thyrotoxicosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Thyrotoxicosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6HCN2, LHX3, TSHR
2MP:00053898.3CGA, TSHR, LHX3, HCN2
3MP:00053798.1LHX3, TG, TSHR, DIO2, CGA
4MP:00036317.5CGA, TSHR, TG, TXNRD2, LHX3, HCN2
5MP:00053767.5LHX3, TXNRD2, TG, TSHR, DIO2, CGA
6MP:00053787.2HCN2, LHX3, TG, TSHR, DIO2, CGA

Publications for Thyrotoxicosis

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Sources:
52PubMed
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Articles related to Thyrotoxicosis:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
Management of severe amiodarone-induced thyrotoxicosis after failure of standard medical treatment. (23540613)
2013
2
Hypokalemic periodic paralysis as first sign of thyrotoxicosis. (23599824)
2013
3
Increased sex hormone-binding globulin levels in children and adolescents with thyrotoxicosis. (23548728)
2013
4
Body mass index and the development of amiodarone-induced thyrotoxicosis in adults with congenital heart disease--a cohort study. (22386642)
2013
5
Incidental detection of hyperfunctioning thyroid cancer metastases in patients presenting with thyrotoxicosis. (22837931)
2012
6
Gynaecomastia as the initial presentation of thyrotoxicosis. (23565425)
2012
7
Total thyroidectomy for amiodarone-associated thyrotoxicosis: should surgery always be delayed for pre-operative medical preparation? (22613770)
2012
8
Thyrotoxicosis presenting as acute bulbar palsy. (21751598)
2011
9
Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis. (20551140)
2011
10
The association of insulin resistance with subclinical thyrotoxicosis. (21834678)
2011
11
Resistant thyrotoxicosis in a patient with graves disease: a case report. (21845211)
2011
12
Thyrotoxicosis. (21819001)
2011
13
Takotsubo cardiomyopathy precipitated by thyrotoxicosis. (21054211)
2010
14
Repetitive monomorphic ventricular tachycardia as a manifestation of suboptimally treated thyrotoxicosis. (22022738)
2010
15
Thyrotoxicosis factitia induces Takotsubo cardiomyopathy in end-stage renal disease: a pathogenetic hypothesis. (20150943)
2010
16
The correlation between left ventricular failure and right ventricular systolic dysfunction occurring in thyrotoxicosis. (20589198)
2010
17
A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. (19628289)
2010
18
Iodinated contrast prior to evaluation for thyrotoxicosis. (19263484)
2009
19
A Case of Amiodarone-Induced Thyrotoxicosis: A diagnostic and therapeutic dilemma. (21509317)
2009
20
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
21
Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism. (18941937)
2008
22
Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004. (18602654)
2008
23
Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. (18412797)
2008
24
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
25
Impact of thyroid metabolism on the course of INR levels in a patient with systemic anticoagulation suffering from amiodarone-induced thyrotoxicosis. (17943696)
2007
26
Tailor treatment to the patient in thyrotoxicosis. (17784663)
2007
27
Thyrotoxicosis with coronary spasm that required coronary artery bypass surgery. (18057764)
2007
28
Amiodarone-induced thyrotoxicosis: clinical course and predictors of outcome. (17572251)
2007
29
Management of amiodarone-induced thyrotoxicosis in Latin America: an electronic survey. (16984234)
2006
30
Cardiomyopathy and thyrotoxicosis: tachycardiomyopathy or thyrotoxic cardiomyopathy? (16485742)
2006
31
A cluster of thyrotoxicosis associated with consumption of a soy milk product. (16366059)
2005
32
Secondary osteoporosis: thyrotoxicosis, rheumatoid arthritis, and diabetes mellitus. (15221485)
2004
33
Contrast-induced thyrotoxicosis. (15332308)
2004
34
Recurrent gestational thyrotoxicosis presenting as recurrent hyperemesis gravidarum--report of two cases. (15763786)
2004
35
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
36
Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. (14715479)
2003
37
Thyrotoxicosis--surgical management in the era of evidence-based medicine: experience in western India with 752 cases. (12471001)
2002
38
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
39
McCune-Albright syndrome with thyrotoxicosis. (11564936)
2001
40
Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C. (7718983)
1995
41
Thyrotoxicosis presenting as generalized pruritic exfoliative dermatitis and fever. (1386765)
1992
42
Choriogonadotropin-mediated thyrotoxicosis in a man. (2049833)
1991
43
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
44
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. (6637335)
1983
45
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
46
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
47
Concomitant pernicious anemia and thyrotoxicosis. A case report and discussion. (5409998)
1970
48
Thyrotoxicosis and gigantism associated with "Klinefelter's syndrome". (5850468)
1965
49
Neonatal thyrotoxicosis. (13731873)
1960
50
Uropepsin excretion in neurocirculatory asthenia and thyrotoxicosis. (13381999)
1956

Variations for Thyrotoxicosis

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Expression for genes affiliated with Thyrotoxicosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Thyrotoxicosis

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45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 3BitterDB, 51PharmGKB
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Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1sodium iodide459.9TSHR, TG
2asparagine459.8TXNRD2, TSHR
3cytosine45 2410.8TSHR, TXNRD2
4prednisolone45 29 1111.7TSHR, TG
5selenocysteine45 24 1111.7DIO2, TXNRD2
6carbohydrates459.6TSHR, TG
7adenine45 24 1111.5TSHR, TXNRD2
8guanine45 24 1111.5TXNRD2, TG, TSHR
9sialic acid459.4CGA, TSHR, TG
10thymidine45 2410.4TSHR, TG, TXNRD2
11paraffin459.4TG, TSHR, CGA
12propylthiouracil45 3 1111.4TG, TSHR, DIO2
13iodine45 2410.4DIO2, TSHR, TG
14125i459.4DIO2, TSHR, TG
15iodide45 2410.4TG, TSHR, DIO2
16methimazole45 3 1111.4DIO2, TSHR, TG
17adenylate459.3CGA, TSHR, TG
18forskolin45 51 1111.3CGA, DIO2, TSHR
19selenium45 2410.3DIO2, TG, TXNRD2
20h2o2459.2CGA, TG, TXNRD2
21vegf459.2TG, TSHR, CGA
22carbachol45 29 1111.1CGA, TG
23threonine459.1DIO2, TSHR, TXNRD2
24glutamate459.1TG, TSHR, CGA
25cycloheximide459.0CGA, DIO2, TG
26sodium45 2410.0HCN2, TG, TSHR
27cyclic amp45 2410.0HCN2, TSHR, CGA
28aspartate459.0TXNRD2, TG, TSHR, CGA
29arginine458.9CGA, TSHR, TG, TXNRD2
30retinoic acid45 249.8DIO2, TSHR, TG, TXNRD2
31ribonucleic acid458.8TG, TSHR, DIO2, CGA
32tyrosine458.4LHX3, TXNRD2, TG, TSHR, DIO2
33triiodothyronine458.4CGA, DIO2, TSHR, TG, TXNRD2
34thyroxine45 249.4TXNRD2, TG, TSHR, DIO2, CGA
35alanine458.4CGA, DIO2, TSHR, TG, TXNRD2
36estrogen458.4TXNRD2, TG, TSHR, DIO2, CGA
37serine458.3TXNRD2, TG, TSHR, DIO2, CGA
38cysteine457.7DIO2, TSHR, TG, TXNRD2, LHX3, HCN2

GO Terms for genes affiliated with Thyrotoxicosis

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16Gene Ontology
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Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.2DIO2, TG
2thyroid gland developmentGO:0308789.1TG, CGA
3thyroid hormone generationGO:0065908.8CGA, DIO2, TG
4cell-cell signalingGO:0072678.8CGA, TSHR, HCN2

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4CGA, TG

Products for genes affiliated with Thyrotoxicosis

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  • Antibodies
  • Proteins
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Sources for Thyrotoxicosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet