MCID: THY033
MIFTS: 58

Thyrotoxicosis malady

Endocrine diseases category

Summaries for Thyrotoxicosis

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Hyperthyroidism, often referred to as an overactive thyroid, is a condition in which the thyroid gland... more...

MalaCards: Thyrotoxicosis is related to thyroiditis and neonatal thyrotoxicosis. An important gene associated with Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor), and among its related pathways are Insulin secretion and Regulation of thyroid hormone activity. The drugs thyroglobulin and thyroid (usp) and the compounds cycloheximide and forskolin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are endocrine/exocrine gland and growth/size.

Description from OMIM:46 275000

Aliases & Classifications for Thyrotoxicosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 46OMIM, 34MeSH, 39NCIt, 25ICD10
See all sources

Related Diseases for Thyrotoxicosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3CGA, TRH, SERPINA7, TSHR, TPO, TG
2neonatal thyrotoxicosis31.0LHX3, TSHR
3graves' disease30.7DIO2, CGA, LMOD1, SERPINA7, TSHR, TPO
4hyperthyroidism30.6TXNRD2, CA1, DIO2, CGA, TRH, LMOD1
5goiter30.6TRH, LMOD1, SERPINA7, TSHR, TPO, TG
6hypothyroidism30.6TRH, TSHR, TPO, TG
7hypertension30.4ADM
8myxedema30.3TSHR, TPO, TG
9exophthalmos30.3TRH, TSHR
10subacute thyroiditis30.3TG
11hepatitis30.3SERPINA7, SORD
12multinodular goiter30.3TG, TPO, TSHR
13thyroid cancer30.2TXNRD2, DIO2, TRH, TSHR, TPO, TG
14endemic goiter30.1TSHR, TPO, TG
15pernicious anemia30.1TPO, TG
16follicular thyroid carcinoma30.1TG, TSHR
17adenoma30.1TSHR, TPO, TG, LMOD1, TRH, PROP1
18diabetes insipidus30.0TRH
19diabetes mellitus30.0SORD
20autoimmune thyroiditis30.0TPO, TG
21nodular goiter30.0TSHR, TPO, TG
22hypopituitarism30.0LHX3, CGA, PROP1, TRH
23hyperthyroxinemia30.0TRH, SERPINA7, TSHR, TPO
24choriocarcinoma30.0ADM, CGB7, CGA, DIO3
25struma ovarii29.9TG, TSHR
26toxic diffuse goiter29.9TSHR, TPO, TG
27papillary thyroid carcinoma29.9TSHR, TPO, TG
28addison's disease29.9TG, TPO
29papillary carcinoma29.9TSHR, TPO, TG
30cushing's syndrome29.7TRH
31endogenous depression29.7TRH
32nontoxic goiter29.7TG, TPO, TSHR
33hypogonadism29.7TRH, PROP1, CGA
34thyroid hormone resistance syndrome29.7TG, SERPINA7, TRH, TXNRD2
35infertility29.7TXNRD2, CGA, IL11, TPO
36tuberculosis29.7TPO, IL11
37acute thyroiditis10.3
38suppurative thyroiditis10.3
39hypokalemic periodic paralysis10.3
40cerebritis10.1
41exophthalmic ophthalmoplegia10.1
42hepatitis c10.1
43myocardial infarction10.1
44ophthalmoplegia10.1
45periarthritis10.0
46pituitary apoplexy10.0
47hypercalcemia10.0
48sick sinus syndrome10.0
49hepatitis a10.0
50congestive heart failure10.0

Graphical network of the top 20 diseases related to Thyrotoxicosis:



Diseases related to thyrotoxicosis

Clinical Features for Thyrotoxicosis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

275000

Drugs & Therapeutics for Thyrotoxicosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Thyrotoxicosis

Drug clinical trials:

Search ClinicalTrials for Thyrotoxicosis

Search NIH Clinical Center for Thyrotoxicosis

Search CenterWatch for Thyrotoxicosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Thyrotoxicosis

About this section

Anatomical Context for Thyrotoxicosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Thyrotoxicosis:

32
Thyroid, Heart, Pituitary, Bone, Testes, Liver, Brain, Bone marrow

Animal Models for Thyrotoxicosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Thyrotoxicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7CGA, PROP1, TRH, TSHR, TPO, TG
2MP:00053789.0LHX3, DIO3, DIO2, CGA, PROP1, TRH
3MP:00053768.7TG, TXNRD2, LHX3, SORD, DIO3, DIO2

Publications for Thyrotoxicosis

About this section
Sources:
50PubMed
See all sources

Articles related to Thyrotoxicosis:

(show top 50)    (show all 680)
idTitleAuthorsYear
1
Acute liver failure with thyrotoxicosis treated with liver transplantation. (23337142)
2013
2
Thyrotoxicosis after a massive levothyroxine ingestion in a 3-year-old patient. (24196094)
2013
3
Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: A case report. (24265247)
2013
4
Death rates for acquired hypothyroidism and thyrotoxicosis in English populations (1979-2010): comparison of underlying cause and all certified causes. (23349406)
2013
5
Broken heart syndrome triggered by an obstructive goiter not associated with thyrotoxicosis. (23842757)
2013
6
Ocular myasthenia gravis in a setting of thyrotoxicosis. (23776918)
2013
7
Gynaecomastia as the initial presentation of thyrotoxicosis. (23565425)
2012
8
Significant role of serum CRP in differentiating inflammatory from non-inflammatory causes of thyrotoxicosis. (23226645)
2012
9
Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis. (20551140)
2011
10
Resistant thyrotoxicosis in a patient with graves disease: a case report. (21845211)
2011
11
Importance of (99)mTc-sestaMIBI thyroid scan in a case of amiodarone-induced thyrotoxicosis. (22147098)
2011
12
Hiccup: an extremely rare presentation of thyrotoxicosis of graves' disease. (22043400)
2011
13
Estrogens modulate RANKL-RANK/osteoprotegerin mediated interleukin-6 effect on thyrotoxicosis-related bone turnover in mice. (21332025)
2011
14
Continuation of amiodarone delays restoration of euthyroidism in patients with type 2 amiodarone-induced thyrotoxicosis treated with prednisone: a pilot study. (21865355)
2011
15
The correlation between left ventricular failure and right ventricular systolic dysfunction occurring in thyrotoxicosis. (20589198)
2010
16
Acute myocardial infarction as the first presentation of thyrotoxicosis in a 31-year old woman - case report. (20181115)
2010
17
Autoimmune thyrotoxicosis with achalasia cardia. (19802553)
2009
18
Hyperthyroidism or thyrotoxicosis? (NOVEMBER 2008). (19258460)
2009
19
The fetal heart monitor tracing in pregnancies complicated by fetal thyrotoxicosis. (19067279)
2009
20
Pathophysiological basis for thyrotoxicosis as an aggravating factor in post-ischemic brain injury in rats. (18252957)
2008
21
Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats. (18182466)
2008
22
Thyrotoxicosis during sunitinib treatment for renal cell carcinoma. (18394019)
2008
23
Graves' thyrotoxicosis and coronary artery spasm. (17989261)
2007
24
A novel MR-imaging technique using arterial spin labeling for thyroid gland perfusion in thyrotoxicosis. (17714034)
2007
25
Thyrotoxicosis presenting with headache. (17598793)
2007
26
Improved prediction of relapse of Graves' thyrotoxicosis by combined determination of TSH receptor and thyroperoxidase antibodies. (17226115)
2007
27
Differentiated thyroid cancer presenting with thyrotoxicosis due to functioning metastases. (17495053)
2007
28
Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study. (17103224)
2007
29
How we do it: surgery should be considered equally with I131 and thionamide treatment as first-line therapy for thyrotoxicosis. (16620341)
2006
30
Mild and short recurrence of type II amiodarone-induced thyrotoxicosis in three patients receiving amiodarone continuously for more than 10 years. (16829703)
2006
31
Thyrotoxicosis and pulmonary hypertension. (16084191)
2005
32
Low failure rate of fixed administered activity of 400 MBq 131I with pre-treatment with carbimazole for thyrotoxicosis: the Gateshead Protocol. (15208494)
2004
33
A quality improvement study: medication error leading to thyrotoxicosis and death. (15530181)
2004
34
Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns. (15906722)
2003
35
Gestational transient thyrotoxicosis. (14574663)
2003
36
Scintigraphic manifestations of thyrotoxicosis. (12853661)
2003
37
Malignant struma ovarii with thyrotoxicosis. (11520159)
2001
38
A man with thyrotoxicosis, lymphoma and thymic hyperplasia. (11732296)
2001
39
Recurrent fetal thyrotoxicosis in a woman with Graves' disease: case report. (10584424)
1999
40
Nonfamilial hypokalemic periodic paralysis and thyrotoxicosis in a 16-year-old male. (9282719)
1997
41
Thyrotoxicosis and renal tubular acidosis presenting as hypokalaemic paralysis. (8620307)
1996
42
Thyrotoxicosis and hungry bone syndrome--a cause of posttreatment hypocalcemia. (8200118)
1994
43
Thymic hyperplasia associated with Hodgkin disease and thyrotoxicosis. (1525776)
1992
44
Thyrotoxicosis induced sick sinus syndrome: medical therapy may avoid permanent pacing. (1695346)
1990
45
Historical role of endemic goiter in elucidating the importance of iodine nutrition, the function and control of thyroid gland, the structure of thyroid hormone, and the use of antithyroid drugs in thyrotoxicosis. (2422010)
1986
46
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
47
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. (830919)
1977
48
Concomitant pernicious anemia and thyrotoxicosis. A case report and discussion. (5409998)
1970
49
ABSORPTION AND DISPOSITION OF D-XYLOSE IN THYROTOXICOSIS AND MYXEDEMA. (14085591)
1964
50
The sequential occurrence of acute thyroiditis and thyrotoxicosis. (13211328)
1955

Genetic Variations for Thyrotoxicosis

About this section

Expression for genes affiliated with Thyrotoxicosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Thyrotoxicosis

Search GEO for disease gene expression data for Thyrotoxicosis.

Pathways for genes affiliated with Thyrotoxicosis

About this section
Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database
See all sources

Pathways related to Thyrotoxicosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TG, TPO
2
Hide members
10.2TPO, DIO2
3
Hide members
10.1TSHR, TPO, TG
410.1DIO2, DIO3, TXNRD2
510.1DIO2, DIO3, TXNRD2

Compounds for genes affiliated with Thyrotoxicosis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Thyrotoxicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6TRH, DIO2
2forskolin44 49 1112.5IL11, TSHR, ADM
3sodium iodide4410.4TSHR, TPO, TG
43,3-diiodothyronine4410.4DIO3, LMOD1, DIO2
5Liothyronine11 2411.3DIO2, TPO, SERPINA7
6amiodarone44 49 28 1113.3TG, TPO, SERPINA7, LMOD1
7selenium44 2411.3TG, DIO2, TPO, TXNRD2
8selenocysteine44 11 2412.3LMOD1, TXNRD2, DIO3, DIO2
9methimazole44 2 1112.2SERPINA7, TSHR, DIO2, TPO, TG, TRH
10n-bromoacetyl-3,3,5-triiodo-l-thyronine4410.2DIO2, LMOD1
11propylthiouracil44 2 1112.2TSHR, TPO, LMOD1, DIO2, DIO3, TG
12dithiothreitol4410.1TRH, DIO2, TPO, DIO3, LMOD1
13iodotyrosine44 2411.1TPO, TG
14asparagine4410.1TPO, TSHR, TXNRD2, SERPINA7
15hydrocortisone44 2 59 1113.1TRH, SLPI, ADM, TPO, TG
16serine4410.1TSHR, CGA, DIO2, TXNRD2, PROP1
17gnrh4410.1LHX3, CGA, CGB7, PROP1, TRH
18carbachol44 28 1112.1CGA, SLPI, IL11, ADM, TG
19acetylcholine44 49 28 11 2414.1TPO, ADM, TRH
20iodine44 2411.0TG, TPO, LMOD1, TSHR, SERPINA7, TRH
21iodide44 2411.0LMOD1, TG, TPO, SERPINA7, DIO3, DIO2
22ribonucleic acid4410.0IL11, TG, TPO, TSHR, CGA, SERPINA7
23acth4410.0ADM, TSHR, TRH, SERPINA7, IL11, PROP1
24dexamethasone44 49 28 1113.0TRH, DIO3, SLPI, LMOD1, DIO2
25norepinephrine44 11 2412.0ADM, TG, TRH, CGA, CA1, SLPI
26thymidine44 2410.9TRH, IL11, SLPI, TXNRD2, TG, ADM
27125i449.9ADM, TPO, TSHR, TG, DIO3, DIO2
28hydrogen44 2410.9TXNRD2, TSHR, TRH, SORD, TPO, CA1
29creatinine449.9CGA, SLPI, SORD, ADM, TPO, TG
30progesterone44 59 28 11 2413.9SERPINA7, ADM, TSHR, IL11, TRH, CGB7
31lactate449.9SLPI, ADM, CGB7, TG, CGA, SORD
32cyclic amp44 2410.9CGA, SLPI, TSHR, TRH, HCN2, IL11
33sodium44 2410.9HCN2, SLPI, TSHR, TPO, TG, ADM
34dopamine44 28 11 2412.8IL11, SERPINA7, LMOD1, TRH, CGA, DIO2
35steroid449.8SLPI, IL11, PROP1, CGA, TXNRD2, TPO
36adenylate449.8TRH, CGA, TG, TSHR, ADM, TPO
37arginine449.8SERPINA7, TRH, CGA, TXNRD2, CA1, TSHR
38estradiol44 11 2411.8TSHR, SERPINA7, IL11, TRH, CGB7, CGA
39oligonucleotide449.7TPO, TRH, IL11, TSHR, SLPI, SORD
40aspartate449.7IL11, SORD, TXNRD2, TSHR, TPO, CGA
41retinoic acid44 2410.7DIO2, TXNRD2, CGB7, IL11, SLPI, TPO
42triiodothyronine449.7DIO2, TXNRD2, DIO3, CGA, TRH, LMOD1
43glucose449.7SLPI, SORD, DIO2, TRH, IL11, SERPINA7
44mannitol44 1110.6ADM, SLPI, CGA, SORD
45testosterone44 59 11 2412.5TPO, SORD, CGA, CGB7, PROP1, SLPI
46thyroxine44 2410.5TG, TPO, TSHR, SERPINA7, TRH, CGB7
47alanine449.5TG, ADM, TSHR, SERPINA7, SLPI, CGA
48estrogen449.4CGA, TG, ADM, TSHR, SLPI, LMOD1
49tyrosine449.3LHX3, DIO2, TRH, IL11, LMOD1, SERPINA7
50cysteine449.2HCN2, IL11, TG, LMOD1, DIO3, ADM

GO Terms for genes affiliated with Thyrotoxicosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3TG, ADM, SERPINA7, SLPI, IL11, PCDHA1

Biological processes related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid gland developmentGO:03087810.2TG, CGA
2hormone biosynthetic processGO:04244610.0DIO3, DIO2, TPO, TG
3thyroid hormone generationGO:0065909.9TG, TPO, CGA, DIO2, DIO3
4response to corticosterone stimulusGO:0514129.9SERPINA7, TRH
5cell-cell signalingGO:0072679.6CGA, TRH, HCN2, IL11, TSHR, ADM

Molecular functions related to Thyrotoxicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.1TG, ADM, CGA
2thyroxine 5-deiodinase activityGO:0048009.9DIO2, DIO3

Products for genes affiliated with Thyrotoxicosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyrotoxicosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet