MCID: THY041
MIFTS: 22

Thyroxine-Binding Globulin Deficiency malady

Summaries for Thyroxine-Binding Globulin Deficiency

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Thyroxine-binding globulin (TBG) binds thyroid hormone in circulation. It is one of three proteins... more...

MalaCards: Thyroxine-Binding Globulin Deficiency is related to hypothyroidism and congenital hypothyroidism. An important gene associated with Thyroxine-Binding Globulin Deficiency is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7). The compounds iodine and amiodarone have been mentioned in the context of this disorder. Affiliated tissues include thyroid and liver.

Description from OMIM:46 314200

Aliases & Classifications for Thyroxine-Binding Globulin Deficiency

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Sources:
46OMIM, 60UMLS
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Aliases & Descriptions:

thyroxine-binding globulin deficiency 46 60


Related Diseases for Thyroxine-Binding Globulin Deficiency

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Thyroxine-Binding Globulin Deficiency:



Diseases related to thyroxine-binding globulin deficiency

Clinical Features for Thyroxine-Binding Globulin Deficiency

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46OMIM
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Clinical features from OMIM:

314200

Clinical synopsis from OMIM:

314200

Drugs & Therapeutics for Thyroxine-Binding Globulin Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Thyroxine-Binding Globulin Deficiency

Search CenterWatch for Thyroxine-Binding Globulin Deficiency

Genetic Tests for Thyroxine-Binding Globulin Deficiency

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Anatomical Context for Thyroxine-Binding Globulin Deficiency

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32MalaCards
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MalaCards organs/tissues related to Thyroxine-Binding Globulin Deficiency:

32
Thyroid, Liver

Animal Models for Thyroxine-Binding Globulin Deficiency or affiliated genes

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Publications for Thyroxine-Binding Globulin Deficiency

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Genetic Variations for Thyroxine-Binding Globulin Deficiency

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Expression for genes affiliated with Thyroxine-Binding Globulin Deficiency

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Thyroxine-Binding Globulin Deficiency

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Pathways for genes affiliated with Thyroxine-Binding Globulin Deficiency

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Compounds for genes affiliated with Thyroxine-Binding Globulin Deficiency

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience
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Compounds related to Thyroxine-Binding Globulin Deficiency according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1iodine44 2410.4TG, SERPINA7
2amiodarone44 49 28 1112.4TG, SERPINA7
3125i449.4SERPINA7, TG
4iodide44 2410.4TG, SERPINA7
5methimazole44 2 1111.4SERPINA7, TG
6triiodothyronine449.4SERPINA7, TG
7sodium dodecylsulfate449.4SERPINA7, TG
8sialic acid449.3SERPINA7, TG
9thyroxine44 2410.3TG, SERPINA7
10vitamin a44 11 2411.3SERPINA7, TG
11ribonucleic acid449.2TG, SERPINA7
12creatinine449.2TG, SERPINA7
13aspartate449.1SERPINA7, TG
14alanine449.1SERPINA7, TG
15testosterone44 59 11 2412.0SERPINA7, TG
16arginine448.8TG, SERPINA7

GO Terms for genes affiliated with Thyroxine-Binding Globulin Deficiency

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16Gene Ontology
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Cellular components related to Thyroxine-Binding Globulin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1TG, SERPINA7

Products for genes affiliated with Thyroxine-Binding Globulin Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Thyroxine-Binding Globulin Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet