MCID: TCD001
MIFTS: 47

Tic Disorder malady

Mental diseases category

Summaries for Tic Disorder

About this section


Disease Ontology:10 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary: Tic Disorder is related to chronic tic disorder and attention deficit-hyperactivity disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are GPCRs, Other and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drug clonazepam and the compounds (-)-sulpiride and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and skin, and related mouse phenotype behavior/neurological.

Wikipedia:65 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

About this section

Related Diseases for Tic Disorder

About this section

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1chronic tic disorder31.2OFCC1, DRD4, DNAJC13, AKAP17A
2attention deficit-hyperactivity disorder31.0TPH2, HTR2A, DRD4, DRD2
3gilles de la tourette syndrome30.8HTR2A, DRD4, DRD2
4obsessive-compulsive disorder30.8TPH2, HTR2A, DRD4, DRD2
5schizophrenia30.2TPH2, HTR2A, DRD4, DRD2
6oppositional defiant disorder30.1DRD4
7anxiety disorder30.1TPH2
8conduct disorder30.1DRD4, DRD2
9migraine30.0HTR2A, DRD4, DRD2
10transient tic disorder10.5
11trichotillomania10.3
12neuronitis10.2
13autism spectrum disorder10.2
14blindness10.2
15neuroleptic malignant syndrome10.0DRD2
16huntington disease10.0
17fragile x syndrome10.0
18motor neuron disease10.0
19autoimmune thyroiditis10.0
20rheumatic fever10.0
21common cold10.0
22arteriovenous malformation10.0
23restless legs syndrome10.0
24dystonia10.0
25migraine with aura10.0
26thyroiditis10.0
27childhood-onset schizophrenia10.0
28pandas10.0
29sydenham's chorea10.0
30mental retardation10.0
31ataxia10.0
32tremor10.0
33pathological gambling10.0DRD2, DRD4
34delusional disorder10.0DRD2, DRD4
35heroin dependence10.0DRD4, DRD2
36substance dependence10.0DRD2, DRD4
37substance abuse10.0DRD4, DRD2
38hyperprolactinemia10.0DRD4, DRD2
39major depressive disorder and accelerated response to antidepressant drug treatment10.0DRD4, HTR2A
40personality disorder10.0DRD2, DRD4, TPH2
41bipolar disorder10.0DRD2, HTR2A
42antisocial personality disorder10.0DRD2, HTR2A
43anorexia nervosa10.0HTR2A, DRD4
44narcolepsy10.0DRD2, HTR2A
45panic disorder10.0TPH2, HTR2A, DRD4
46alcohol dependence10.0DRD2, DRD4, HTR2A
47parkinson disease, late-onset10.0DRD2, DRD4, HTR2A
48nicotine dependence, protection against10.0DRD2, HTR2A
49obesity10.0DRD2, DRD4, HTR2A
50psychotic disorder10.0DRD2, DRD4, HTR2A, TPH2

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Symptoms for Tic Disorder

About this section

Drugs & Therapeutics for Tic Disorder

About this section

Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Tic Disorder

About this section

Anatomical Context for Tic Disorder

About this section

MalaCards organs/tissues related to Tic Disorder:

33
Brain, Thyroid, Skin, B cells

Animal Models for Tic Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Tic Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4DRD2, DRD4, HTR2A, TPH2, HSPD1

Publications for Tic Disorder

About this section

Articles related to Tic Disorder:

(show top 50)    (show all 125)
idTitleAuthorsYear
1
Clinical Characteristics of Pediatric Trichotillomania: Comparisons with Obsessive-Compulsive and Tic Disorders. (25894516)
2015
2
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. (25020072)
2014
3
Reward enhances tic suppression in children within months of tic disorder onset. (25220075)
2014
4
Post-operative Adult Onset Tic Disorder: A Rare Presentation. (25336779)
2014
5
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). (24633901)
2014
6
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
7
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. (24343476)
2013
8
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. (23821420)
2013
9
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. (21431421)
2011
10
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. (21241949)
2011
11
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. (20378921)
2011
12
Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. (20143146)
2010
13
Tic Disorder: An Unusual Presentation of Neurotoxoplasmosis in a Patient with AIDS. (21113285)
2010
14
Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder. (21053620)
2010
15
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. (19864199)
2009
16
Aripiprazole treatment in an adolescent patient with chronic motor tic disorder and treatment-resistant obsessive-compulsive disorder. (19706223)
2009
17
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. (19698938)
2009
18
Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. (20035592)
2009
19
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
20
Open label aripiprazole in the treatment of youth with tic disorders. (19702496)
2009
21
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. (18439116)
2008
22
Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorder. (17896073)
2008
23
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. (17717739)
2008
24
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
25
Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity. (17537072)
2007
26
Plasma kynurenine and related measures in tic disorder patients. (17665285)
2007
27
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. (17171537)
2007
28
An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disorders. (17685747)
2007
29
Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats. (17013915)
2006
30
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. (17052389)
2006
31
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. (16536367)
2006
32
A case of adult onset tic disorder following carbon monoxide intoxication. (15198457)
2004
33
Transient tic disorder following carbon monoxide poisoning. (15356451)
2004
34
Association of small life events with self reports of tic severity in pediatric and adult tic disorder patients: a prospective longitudinal study. (15096084)
2004
35
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. (11694329)
2001
36
History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. (11295792)
2001
37
Quetiapine for tic disorder: a case report. (11853307)
2001
38
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
39
Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. (10823299)
2000
40
Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder. (11063087)
2000
41
A functional-analytic approach to the diagnosis of a transient tic disorder. (8959431)
1996
42
Psychotic symptoms and a diagnosis of schizophrenia follow an initial diagnosis of tic disorder. (8973056)
1996
43
Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. (7771914)
1995
44
Tic disorder associated with encephalopathy in advanced HIV disease. (7926707)
1994
45
Nortriptyline treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8428873)
1993
46
Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8444765)
1993
47
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. (8227493)
1993
48
A case of post-traumatic tic disorder. (2682216)
1989
49
Auditory hallucinosis and atypical tic disorder: case reports. (4030705)
1985
50
Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome. (3974894)
1985

Variations for Tic Disorder

About this section

Expression for genes affiliated with Tic Disorder

About this section

Search GEO for disease gene expression data for Tic Disorder.

Pathways for genes affiliated with Tic Disorder

About this section

Compounds for genes affiliated with Tic Disorder

About this section

Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride309.9DRD2, DRD4
2(+)-sulpiride309.9DRD2, DRD4
3clotiapine459.9HTR2A, DRD2
4eticlopride45 3010.9DRD2, DRD4
5(11c)-n-methylspiperone459.9DRD2, HTR2A
6l-741,62661 3010.8HTR2A, DRD2
7nemonapride45 51 3011.8DRD4, DRD2
8amperozide459.8HTR2A, DRD2
9eedq459.8DRD2, HTR2A
10molindone30 1310.7HTR2A, DRD2
11amisulpride45 30 1311.7HTR2A, DRD2
12sch 23390459.7DRD4, DRD2
13aniracetam45 30 1311.6DRD2, HTR2A
14zuclopenthixol45 51 1311.6DRD2, HTR2A
15piribedil30 4510.6DRD2, DRD4
16melperone459.6DRD2, DRD4, HTR2A
17(+)-butaclamol45 3010.6HTR2A, DRD4, DRD2
18remoxipride45 1310.6DRD4, HTR2A, DRD2
19loxapine30 45 1311.6DRD4, DRD2, HTR2A
20raclopride45 3010.6DRD2, DRD4, HTR2A
21roxindole30 4510.6DRD4, HTR2A, DRD2
22fluphenazine30 45 51 1312.6DRD4, HTR2A, DRD2
23terguride45 3010.6DRD2, DRD4, HTR2A
24piperazine45 1310.6HTR2A, DRD4, DRD2
25spiperone45 3010.6DRD4, DRD2, HTR2A
26promazine45 1310.6HTR2A, DRD4, DRD2
27ropinirole45 1310.6HTR2A, DRD4, DRD2
28lisuride45 30 1311.6HTR2A, DRD2, DRD4
29pergolide45 30 1311.6HTR2A, DRD2, DRD4
30paliperidone45 1310.6DRD2, DRD4, HTR2A
31iloperidone51 45 30 1312.6DRD4, DRD2, HTR2A
32pramipexole45 30 51 1312.6DRD4, HTR2A, DRD2
33quinpirole45 3010.5DRD4, HTR2A, DRD2
34asenapine30 1310.5HTR2A, DRD4, DRD2
35cabergoline45 30 1311.5HTR2A, DRD4, DRD2
36aripiprazole30 45 51 26 1313.5HTR2A, DRD2, DRD4
37ziprasidone30 51 45 1312.5DRD4, HTR2A, DRD2
38apomorphine30 45 1311.5DRD2, DRD4, HTR2A
39quetiapine45 51 30 26 1313.5DRD4, HTR2A, DRD2
40bromocriptine45 30 1311.5DRD2, DRD4, HTR2A
41chlorpromazine30 45 51 1312.5HTR2A, DRD4, DRD2
42risperidone45 51 30 61 26 1314.5HTR2A, DRD4, DRD2
43fluoxetine45 51 30 1312.5HTR2A, DRD2, TPH2
44olanzapine45 51 30 26 1313.4DRD4, DRD2, HTR2A
45thiothixene30 1310.4DRD2, HTR2A
46clozapine45 30 51 1312.3DRD2, DRD4, HTR2A
47maoa459.2HTR2A, DRD2, DRD4, TPH2
48fluspirilene30 45 1311.2HTR2A, DRD2
495-hydroxytryptamine459.2TPH2, DRD4, HTR2A, DRD2
50haloperidol45 51 30 3 1313.2DRD2, DRD4, HTR2A

GO Terms for genes affiliated with Tic Disorder

About this section

Cellular components related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:00431979.6DRD2, DRD4

Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:00347769.9DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:00515869.9DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:019013869.9DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.9DRD4, DRD2
5behavioral response to ethanolGO:00481499.9DRD2, DRD4
6dopamine metabolic processGO:00424179.8DRD4, DRD2
7negative regulation of protein secretionGO:00507099.8DRD4, DRD2
8synaptic transmission, dopaminergicGO:00019639.8DRD4, DRD2
9arachidonic acid secretionGO:00504829.8DRD2, DRD4
10negative regulation of synaptic transmission, glutamatergicGO:00519679.8HTR2A, DRD2
11negative regulation of adenylate cyclase activityGO:00071949.7DRD2, DRD4
12temperature homeostasisGO:00016599.6DRD2, HTR2A
13release of sequestered calcium ion into cytosolGO:00512099.6HTR2A, DRD2
14response to amphetamineGO:00019759.5DRD2, DRD4
15positive regulation of ERK1 and ERK2 cascadeGO:00703749.5DRD2, HTR2A
16behavioral response to cocaineGO:00481489.5DRD2, DRD4, HTR2A
17circadian rhythmGO:00076239.5DRD4, TPH2
18cellular calcium ion homeostasisGO:00068749.5DRD2, DRD4, HTR2A
19B cell activationGO:00421139.4AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.6DRD2, DRD4
2potassium channel regulator activityGO:00154599.6DRD2, DRD4
3dopamine bindingGO:00352409.3DRD2, DRD4
4drug bindingGO:00081449.1DRD2, DRD4, HTR2A

Products for genes affiliated with Tic Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Tic Disorder

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet