MCID: TCD001
MIFTS: 46

Tic Disorder malady

Neuronal diseases category

Summaries for Tic Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards: Tic Disorder is related to chronic tic disorder and attention deficit hyperactivity disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Hypothetical Network for Drug Addiction and Dopamine receptors. The drug clonazepam and the compounds (-)-sulpiride and Thiethylperazine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and b cells.

Wikipedia:63 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Tic Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1chronic tic disorder31.2OFCC1, AKAP17A, DNAJC13, DRD4
2attention deficit hyperactivity disorder31.0HTR2A, DRD2, TPH2, DRD4
3obsessive-compulsive disorder30.8HTR2A, DRD2, DRD4, TPH2
4gilles de la tourette syndrome30.7DRD4, HTR2A, DRD2
5anxiety disorder30.4TPH2, DRD2, HTR2A
6schizophrenia30.1DRD2, DRD4, TPH2, HTR2A
7restless legs syndrome29.9DRD2
8migraine29.9HTR2A, DRD2, DRD4
9psychotic disorder29.9HTR2A, DRD2, DRD4, TPH2
10transient tic disorder10.5
11trichotillomania10.1
12neuronitis10.1
13autism spectrum disorder10.1
14rheumatic fever10.0
15arteriovenous malformation10.0
16pain disorder10.0
17conduct disorder10.0
18common cold10.0
19adult syndrome10.0
20fragile x syndrome10.0
21migraine with aura10.0
22motor neuron disease10.0
23sleep disorder10.0
24withdrawal disorder10.0
25image syndrome10.0
26autistic disorder10.0DRD4
27cocaine dependence10.0DRD2
28alcohol abuse10.0DRD2
29myoclonus-dystonia10.0DRD2
30bulimia nervosa10.0HTR2A
31neuroleptic malignant syndrome10.0DRD2
32heroin dependence10.0DRD4, DRD2
33hyperprolactinemia10.0DRD4, DRD2
34ischemia10.0DRD2
35delusional disorder10.0DRD2, DRD4
36nicotine dependence10.0DRD4, DRD2
37pathological gambling10.0DRD2, DRD4
38anorexia nervosa10.0HTR2A, DRD4
39seasonal affective disorder10.0HTR2A, DRD4
40antisocial personality disorder10.0HTR2A, DRD2
41substance dependence10.0DRD4, DRD2
42personality disorder10.0DRD4, TPH2, DRD2
43alcohol dependence10.0DRD4, HTR2A, DRD2
44panic disorder10.0HTR2A, TPH2, DRD4
45schizoaffective disorder10.0DRD4, HTR2A, DRD2
46type 1 diabetes10.0ACP1, HSPD1
47parkinson's disease10.0DRD4, DRD2, HTR2A
48mood disorder10.0DRD2, DRD4, TPH2, HTR2A
49bipolar disorder10.0DRD2, TPH2, DRD4, HTR2A
50type 2 diabetes mellitus10.0DRD2, ACP1, HTR2A

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Clinical Features for Tic Disorder

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Drugs & Therapeutics for Tic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tic Disorder

Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Search CenterWatch for Tic Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tic Disorder

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Anatomical Context for Tic Disorder

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32MalaCards
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MalaCards organs/tissues related to Tic Disorder:

32
Brain, Skin, B cells

Animal Models for Tic Disorder or affiliated genes

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Publications for Tic Disorder

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Sources:
50PubMed
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Articles related to Tic Disorder:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. (24262815)
2014
2
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
3
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. (23821420)
2013
4
Pharmacotherapeutic challenges in the management of attention-deficit/hyperactivity disorder and chronic tics in a school aged child. (24251645)
2013
5
The effects of awareness training on tics in a young boy with Tourette syndrome, Asperger syndrome, and attention deficit hyperactivity disorder. (24114235)
2013
6
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. (23140273)
2013
7
Type IIB thyroplasty for phonic tics in a pediatric patient with autism spectrum disorder: a case report. (23406841)
2013
8
Pachydermodactyly in a Patient With Generalized Anxiety Disorder and Tics. (24238330)
2013
9
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. (23360517)
2013
10
Exacerbation of obsessive-compulsive disorder, generalized anxiety disorder, and chronic motor tics during treatment of attention-deficit/hyperactivity disorder: medication management in an older adolescent. (24138012)
2013
11
The future of tic disorder treatment. (24175754)
2013
12
A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia. (21915912)
2012
13
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. (22488574)
2012
14
Relationship between movement disorders and obsessive-compulsive disorder: beyond the obsessive-compulsive-tic phenotype. A systematic review. (22448031)
2012
15
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. (21241949)
2011
16
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. (20378921)
2011
17
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. (21520241)
2011
18
Tic Disorder: An Unusual Presentation of Neurotoxoplasmosis in a Patient with AIDS. (21113285)
2010
19
Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder. (21053620)
2010
20
Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder. (20599460)
2010
21
Role of perinatal adversities on tic severity and symptoms of attention deficit/hyperactivity disorder in children and adolescents with a tic disorder. (20110829)
2010
22
The "imprisoned illness:" motor tic disorder in Rainer Maria Rilke's Notebooks of Malte Laurids Brigge. (20669278)
2010
23
Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. (20035592)
2009
24
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
25
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. (18439116)
2008
26
Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. (19120712)
2008
27
Treatment-resistant self-mutilation, tics, and obsessive-compulsive disorder in neuroacanthocytosis: a mouth guard as a therapeutic approach. (18687019)
2008
28
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. (17345600)
2008
29
An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disorders. (17685747)
2007
30
Quality of life in youth with Tourette's syndrome and chronic tic disorder. (17484694)
2007
31
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. (17453897)
2007
32
Quetiapine in the treatment of tic disorder. (16804100)
2006
33
Clinical significance of tics and attention-deficit hyperactivity disorder (ADHD) in children with pervasive developmental disorder. (15996396)
2005
34
Tourette syndrome: not just a tic disorder. (16265842)
2005
35
Carbidopa-levodopa-induced recrudescence of premorbid tic disorder in remission. (16308585)
2005
36
Association of small life events with self reports of tic severity in pediatric and adult tic disorder patients: a prospective longitudinal study. (15096084)
2004
37
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. (15248548)
2004
38
Functional brain imaging in Sydenham's chorea and streptococcal tic disorders. (15224712)
2004
39
Increased seroreactivity in tic disorder patients to a 60 kDa protein band from a neuronal cell line. (12965262)
2003
40
History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. (11295792)
2001
41
Quetiapine for tic disorder: a case report. (11853307)
2001
42
Elevated D8/17 expression on B lymphocytes, a marker of rheumatic fever, measured with flow cytometry in tic disorder patients. (11282696)
2001
43
Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. (10823299)
2000
44
New-onset tic disorder following acute hemorrhage of an arteriovenous malformation. (11108516)
2000
45
Comparison of internalizing and externalizing symptoms in children with attention-deficit hyperactivity disorder with and without comorbid tic disorder. (10393074)
1999
46
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. (8973076)
1996
47
Tic disorder associated with encephalopathy in advanced HIV disease. (7926707)
1994
48
A case of post-traumatic tic disorder. (2682216)
1989
49
Auditory hallucinosis and atypical tic disorder: case reports. (4030705)
1985
50
Clonidine in a case of atypical tic disorder. (6518445)
1984

Genetic Variations for Tic Disorder

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Expression for genes affiliated with Tic Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for genes affiliated with Tic Disorder

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB
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Pathways related to Tic Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DRD4, DRD2
29.8DRD4, DRD2
3
Hide members
9.4DRD4, DRD2, HTR2A
49.2HSPD1, HTR2A, TPH2

Compounds for genes affiliated with Tic Disorder

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Sources:
28IUPHAR, 11DrugBank, 44Novoseek, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride2810.1DRD4, DRD2
2Thiethylperazine1110.1DRD2, DRD4
3(+)-sulpiride2810.1DRD4, DRD2
4clotiapine4410.1HTR2A, DRD2
5(11c)-n-methylspiperone4410.1HTR2A, DRD2
6l-741,62659 2811.0DRD2, HTR2A
7eticlopride28 4411.0DRD2, DRD4
8Mesoridazine1110.0HTR2A, DRD2
9amperozide449.9HTR2A, DRD2
10eedq449.9HTR2A, DRD2
11melperone449.9HTR2A, DRD2, DRD4
12(+)-butaclamol28 4410.8DRD2, HTR2A, DRD4
13loxapine28 44 1111.8DRD2, HTR2A, DRD4
14remoxipride44 1110.8DRD2, HTR2A, DRD4
15raclopride44 2810.8DRD4, DRD2, HTR2A
16roxindole28 4410.8HTR2A, DRD2, DRD4
17Propiomazine119.8DRD4, HTR2A, DRD2
18amisulpride44 28 1111.8DRD2, HTR2A
19terguride28 4410.8HTR2A, DRD2, DRD4
20fluphenazine28 44 1111.8DRD2, DRD4, HTR2A
21piperazine44 1110.8HTR2A, DRD4, DRD2
22spiperone28 4410.8DRD4, DRD2, HTR2A
23ropinirole44 1110.8HTR2A, DRD4, DRD2
24promazine44 1110.8HTR2A, DRD2, DRD4
25lisuride28 44 1111.8DRD4, DRD2, HTR2A
26paliperidone44 1110.8HTR2A, DRD4, DRD2
27sch 23390449.8DRD2, DRD4
28pergolide28 44 1111.8DRD4, DRD2, HTR2A
29Methotrimeprazine119.8DRD4, DRD2, HTR2A
30pramipexole44 49 28 1112.8HTR2A, DRD2, DRD4
31iloperidone49 44 28 1112.8HTR2A, DRD2, DRD4
32quinpirole44 2810.8HTR2A, DRD2, DRD4
33molindone28 1110.8HTR2A, DRD2
34asenapine28 1110.8HTR2A, DRD2, DRD4
35cabergoline28 44 1111.8DRD4, HTR2A, DRD2
36aripiprazole28 49 44 11 2413.8DRD2, HTR2A, DRD4
37ziprasidone49 28 44 1112.8HTR2A, DRD2, DRD4
38apomorphine44 28 1111.8DRD4, DRD2, HTR2A
39quetiapine44 49 28 11 2413.7HTR2A, DRD4, DRD2
40risperidone28 44 49 59 11 2414.7DRD4, DRD2, HTR2A
41nemonapride49 44 2811.7DRD4, DRD2
42bromocriptine28 44 1111.7DRD2, DRD4, HTR2A
43chlorpromazine44 28 49 1112.7HTR2A, DRD2, DRD4
44olanzapine49 44 28 11 2413.5HTR2A, DRD4, DRD2
45trifluoperazine44 28 1111.5ACP1, DRD2, HTR2A
46fluoxetine49 44 28 1112.5TPH2, DRD2, HTR2A
47Lurasidone119.4DRD2, HTR2A
48maoa449.4HTR2A, DRD2, DRD4, TPH2
495-hydroxytryptamine449.3TPH2, DRD4, HTR2A, DRD2
50norepinephrine44 11 2410.9HTR2A, DRD2, DRD4, ACP1

GO Terms for genes affiliated with Tic Disorder

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16Gene Ontology
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Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.1DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.1DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:190138610.1DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD2
5behavioral response to ethanolGO:04814910.1DRD4, DRD2
6dopamine metabolic processGO:04241710.0DRD2, DRD4
7negative regulation of protein secretionGO:05070910.0DRD2, DRD4
8behavioral response to cocaineGO:04814810.0DRD2, DRD4
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A
10synaptic transmission, dopaminergicGO:00196310.0DRD2, DRD4
11regulation of dopamine secretionGO:0140599.9HTR2A, DRD2
12arachidonic acid secretionGO:0504829.9DRD4, DRD2
13negative regulation of adenylate cyclase activityGO:0071949.8DRD4, DRD2
14response to amphetamineGO:0019759.8DRD4, DRD2
15temperature homeostasisGO:0016599.8HTR2A, DRD2
16cellular calcium ion homeostasisGO:0068749.7HTR2A, DRD2, DRD4
17release of sequestered calcium ion into cytosolGO:0512099.6DRD2, HTR2A
18B cell activationGO:0421139.3AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.8DRD4, DRD2
2potassium channel regulator activityGO:0154599.8DRD4, DRD2
3dopamine bindingGO:0352409.5DRD4, DRD2
4drug bindingGO:0081449.3DRD4, DRD2, HTR2A

Products for genes affiliated with Tic Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet