Aliases & Classifications for Tic Disorder

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder is related to autism spectrum disorder and schizophrenia, and has symptoms including symptoms and recurrent muscle twitches (symptom). An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Long-term potentiation. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and b cells, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 71 Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Related Diseases for Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 autism spectrum disorder 29.0 CNR1 DRD4 DRD5 HTR7 SLC6A3
2 schizophrenia 28.2 CNR1 DRD2 DRD4 DRD5 HTR7 SLC18A2
3 chronic tic disorder 12.5
4 transient tic disorder 12.4
5 gilles de la tourette syndrome 11.9
6 pandas 11.1
7 attention deficit-hyperactivity disorder 10.3
8 sphenoorbital meningioma 10.2 DRD2 DRD4
9 obsessive-compulsive disorder 10.2
10 intracranial aneurysm 10.2 DRD2 DRD4 SLITRK1
11 pyromania 10.1 DRD2 DRD4 SLC6A3
12 18p deletion syndrome 10.1 DRD2 DRD4 SLC6A3
13 splenic abscess 10.1 DRD2 SLC6A3
14 colorectal adenocarcinoma 10.1 DRD2 DRD4 SLC6A3 TPH2
15 intracranial cavernous angioma 10.1 DRD2 SLC6A3
16 cecal benign neoplasm 10.1 DRD2 DRD4 SLC6A3 TPH2
17 hepatitis d 10.1 DRD2 DRD4 SLC6A3 TPH2
18 dyskinesia of esophagus 10.0 HTR7 SLITRK1
19 tinea pedis 10.0 HTR7 SLC6A3 SLITRK1
20 mastitis 10.0 DRD4 HTR7 SLC6A3
21 nephrogenic adenoma of the urethra 10.0 DRD2 SLC18A2 SLC6A3
22 carotid stenosis 10.0 DRD2 DRD4 DRD5 SLC6A3
23 retinoblastoma 10.0 DRD2 DRD4 SLC6A3 SLITRK1 TPH2
24 cavernous hemangioma 10.0 DRD2 SLC18A2 SLC6A3
25 lactose intolerance 9.9 DNAJC13 DRD4 HTR7
26 alopecia 9.9 CNR1 DRD2 DRD4
27 alzheimer disease 17 9.9 DRD4 HTR7 SLC18A2 TPH2
28 microcephaly 13, primary, autosomal recessive 9.9 DRD2 DRD4 DRD5 HTR7
29 trichotillomania 9.9
30 mucinous adenocarcinoma 9.9 DRD2 DRD4 DRD5 SLC6A3 TDO2
31 cholesteatoma 9.9 CNR1 DRD2 SLC6A3
32 allergic hypersensitivity disease 9.8 CNR1 DRD2 HTR7
33 vascular cancer 9.8 CNR1 DRD2 HTR7
34 paraphilia disorder 9.8 DRD2 DRD4 IMMP2L KCTD3 SLC6A3 TPH2
35 hemochromatosis, type 2a 9.8 DRD2 SLC18A2 SLC6A3
36 encephalopathy 9.8
37 neuronitis 9.8
38 benign epilepsy with centrotemporal spikes 9.7 CNR1 DRD2 DRD4 SLC18A2 TPH2
39 hypereosinophilic syndrome 9.7 CNR1 DRD2 DRD4 DRD5 SLC6A3
40 chronic conjunctivitis 9.6 CNR1 DRD2 DRD4 SLC18A2 SLC6A3
41 restless legs syndrome 9.6
42 childhood-onset schizophrenia 9.6
43 primary progressive multiple sclerosis 9.6
44 oppositional defiant disorder 9.6
45 ataxia 9.6
46 migraine with aura 9.6
47 tremor 9.6
48 common cold 9.6
49 arteriovenous malformation 9.6
50 conduct disorder 9.6

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


symptoms, recurrent muscle twitches (symptom)

MGI Mouse Phenotypes related to Tic Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 CNR1 DRD2 DRD4 DRD5 HDC HSPD1
2 growth/size/body region MP:0005378 9.97 CNR1 DRD2 HDC HSPD1 IMMP2L SLC18A2
3 homeostasis/metabolism MP:0005376 9.96 SLC6A3 SLITRK1 TDO2 TPH2 CNR1 DRD2
4 nervous system MP:0003631 9.73 DRD4 DRD5 HDC HSPD1 HTR7 SLC18A2
5 integument MP:0010771 9.7 CNR1 DRD2 HDC HTR7 SLC6A3 TDO2
6 taste/olfaction MP:0005394 9.02 CNR1 DRD2 SLC18A2 SLC6A3 TPH2

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 294)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
9
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
10 Piracetam Approved Phase 4 7491-74-9
11
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
12
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
13
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
14
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
15
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
16
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
17
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
18
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
19
Haloperidol Approved Phase 4 52-86-8 3559
20
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
21
Budesonide Approved Phase 4 51333-22-3 63006 5281004
22
Amlodipine Approved Phase 4 88150-42-9 2162
23
Codeine Approved, Illicit Phase 4 76-57-3 5284371
24
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
25
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
26
Cycloserine Approved Phase 4 68-41-7 401 6234
27
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 437-38-7 3345
29
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
30
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
31
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
32
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
33
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
34
Remifentanil Approved Phase 4 132875-61-7 60815
35
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
36
Galantamine Approved Phase 4 357-70-0 9651 908828, 9651
37 tannic acid Approved, Nutraceutical Phase 4
38
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
39 Anabolic Agents Phase 4
40 Androgens Phase 4
41 Antineoplastic Agents, Hormonal Phase 4
42 Hormone Antagonists Phase 4,Phase 3
43 Hormones Phase 4,Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
45 Pharmaceutical Solutions Phase 4,Phase 3
46 Testosterone 17 beta-cypionate Phase 4
47
Testosterone enanthate Phase 4 315-37-7 9416
48 Testosterone undecanoate Phase 4
49 Adrenergic Agents Phase 4,Phase 3,Phase 2
50 Adrenergic Agonists Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 259)
id Name Status NCT ID Phase
1 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Unknown status NCT01813201 Phase 4
2 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4
3 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4
4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4
5 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4
6 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4
8 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4
9 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
10 Comparison 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4
11 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4
12 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4
13 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4
14 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4
15 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4
16 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4
17 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4
18 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4
19 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4
20 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4
21 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Recruiting NCT02457130 Phase 4
22 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Recruiting NCT02988869 Phase 4
23 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Recruiting NCT02689999 Phase 4
24 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Recruiting NCT02939495 Phase 4
25 Impact of Anesthesia Maintenance Methods on Long-term Survival Rate Recruiting NCT02660411 Phase 4
26 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Active, not recruiting NCT01863459 Phase 4
27 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Not yet recruiting NCT03037606 Phase 4
28 The Safety of Dapoxetine/Tadalafil Combination Therapy Not yet recruiting NCT03177746 Phase 4
29 Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery Not yet recruiting NCT03172988 Phase 4
30 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4
31 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Unknown status NCT00183391 Phase 3
32 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
33 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3
34 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3
35 Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727700 Phase 3
36 Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727713 Phase 3
37 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418352 Phase 3
38 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418339 Phase 3
39 Safety & Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01416441 Phase 3
40 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3
41 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3
42 An Open-Label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. Completed NCT00206336 Phase 3
43 A Randomized, Placebo-Controlled, Tourette Syndrome Study. Completed NCT00206323 Phase 3
44 Long-term Safety and Effectiveness of OROS Methylphenidate HCl in Children With Attention Deficit Hyperactivity Disorder Completed NCT00269815 Phase 3
45 A Comparison Between Internet Therapy and Group Therapy for Social Phobia - A Trial Using Cognitive Behavioural Therapy Completed NCT00564967 Phase 3
46 A Multicenter Study Comparing the Efficacy and Safety of OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder Completed NCT00269802 Phase 3
47 Efficacy and Safety Evaluation of Levofloxacin Triple Therapy for Helicobacter Pylori Eradication Completed NCT01131026 Phase 3
48 Efficacy and Safety Study of Udenafil Tablets in Erectile Dysfunction. Completed NCT01305083 Phase 3
49 Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery Completed NCT01837290 Phase 3
50 Pallidal Stimulation and Gilles de la Tourette Syndrome Completed NCT00478842 Phase 3

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Tic Disorder

Genetic tests related to Tic Disorder:

id Genetic test Affiliating Genes
1 Tics 29

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

39
Brain, Skin, B Cells, Thyroid, Globus Pallidus

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 137)
id Title Authors Year
1
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
2
Provisional Tic Disorder: What to tell parents when their child first starts ticcing. ( 27158458 )
2016
3
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
4
Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial. ( 27579050 )
2016
5
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2016
6
Evaluation of cognitive behaviour therapy for paediatric obsessive-compulsive disorder in the context of tic disorders. ( 25843610 )
2015
7
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
8
Clinical Characteristics of Pediatric Trichotillomania: Comparisons with Obsessive-Compulsive and Tic Disorders. ( 25894516 )
2015
9
Late onset tic disorder: A rare occurrence. ( 26310263 )
2015
10
Paroxetine-Related Adult-Onset Tic Disorder: A Presentation of Primary Progressive Multiple Sclerosis. ( 26222974 )
2015
11
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ( 27486363 )
2015
12
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
13
A Case of Atypical Adult-onset Tic Disorder. ( 25888196 )
2015
14
Post-operative Adult Onset Tic Disorder: A Rare Presentation. ( 25336779 )
2014
15
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). ( 24633901 )
2014
16
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. ( 25020072 )
2014
17
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
18
Reward enhances tic suppression in children within months of tic disorder onset. ( 25220075 )
2014
19
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
20
A guide to childhood motor stereotypies, tic disorders and the tourette spectrum for the primary care practitioner. ( 24757265 )
2014
21
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
22
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
23
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
24
The future of tic disorder treatment. ( 24175754 )
2013
25
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. ( 24343476 )
2013
26
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
27
Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey. ( 23516770 )
2013
28
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. ( 23487208 )
2013
29
Clinical Effectiveness of Aripiprazole in Short-term Treatment of Tic Disorder in Children and Adolescents: A Naturalistic Study. ( 23920131 )
2013
30
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. ( 23360517 )
2013
31
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. ( 23140273 )
2013
32
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. ( 23821420 )
2013
33
A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia. ( 21915912 )
2012
34
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
35
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
36
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 A9 2 factorial design study. ( 21331638 )
2011
37
The clinical syndrome of primary tic disorder associated with dystonia: a large clinical series and a review of the literature. ( 21506147 )
2011
38
Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomania. ( 21440858 )
2011
39
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. ( 20378921 )
2011
40
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. ( 21431421 )
2011
41
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. ( 21241949 )
2011
42
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
43
The "imprisoned illness:" motor tic disorder in Rainer Maria Rilke's Notebooks of Malte Laurids Brigge. ( 20669278 )
2010
44
Association of restless legs syndrome, chronic motor tic disorder and migraine with aura: a case of a single family. ( 20155277 )
2010
45
Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. ( 20143146 )
2010
46
A proper name for chronic tic disorder. ( 20889671 )
2010
47
Role of perinatal adversities on tic severity and symptoms of attention deficit/hyperactivity disorder in children and adolescents with a tic disorder. ( 20110829 )
2010
48
Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder. ( 21053620 )
2010
49
Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder. ( 20599460 )
2010
50
Tic Disorder: An Unusual Presentation of Neurotoxoplasmosis in a Patient with AIDS. ( 21113285 )
2010

Variations for Tic Disorder

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 DRD2 DRD4 DRD5 SLC18A2 SLC6A3
2
Show member pathways
11.9 DRD2 DRD4 DRD5
4
Show member pathways
11.7 DRD2 SLC18A2 SLC6A3
5 11.66 HTR7 SLC18A2 TPH2
6 11.59 CNR1 DRD4 HTR7
7
Show member pathways
11.55 DRD2 DRD4 SLC18A2
8 10.99 SLC18A2 SLC6A3
9
Show member pathways
10.98 DRD2 DRD4 DRD5 HTR7
10
Show member pathways
10.97 SLC6A3 TDO2 TPH2
11 10.88 DRD2 DRD5
12 10.58 HTR7 SLC18A2 TPH2

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 CNR1 DNAJC13 DRD2 DRD4 DRD5 HSPD1
2 integral component of plasma membrane GO:0005887 9.17 CNR1 DRD2 DRD4 DRD5 HTR7 SLC18A2
3 non-motile cilium GO:0097730 8.96 DRD2 DRD5

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.78 CNR1 DRD2 SLC6A3
2 locomotory behavior GO:0007626 9.71 DRD2 SLC18A2 SLC6A3
3 adult behavior GO:0030534 9.65 DRD2 SLITRK1
4 response to morphine GO:0043278 9.65 CNR1 DRD2
5 associative learning GO:0008306 9.64 DRD2 DRD5
6 negative regulation of adenylate cyclase activity GO:0007194 9.64 DRD2 DRD4
7 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD4
8 behavioral response to cocaine GO:0048148 9.63 DRD2 DRD4
9 dopamine receptor signaling pathway GO:0007212 9.62 DRD2 DRD4
10 response to iron ion GO:0010039 9.62 DRD2 SLC6A3
11 synaptic transmission, dopaminergic GO:0001963 9.61 DRD2 DRD5
12 behavioral response to ethanol GO:0048149 9.6 DRD2 DRD4
13 dopamine metabolic process GO:0042417 9.59 DRD2 DRD4
14 prepulse inhibition GO:0060134 9.58 DRD2 SLC6A3
15 negative regulation of protein secretion GO:0050709 9.58 DRD2 DRD4
16 response to nicotine GO:0035094 9.58 CNR1 DRD2 SLC6A3
17 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.57 DRD2 DRD5
18 negative regulation of voltage-gated calcium channel activity GO:1901386 9.56 DRD2 DRD4
19 regulation of synaptic transmission, GABAergic GO:0032228 9.55 CNR1 DRD2
20 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.52 DRD2 DRD4
21 regulation of dopamine metabolic process GO:0042053 9.51 DRD4 SLC6A3
22 adenohypophysis development GO:0021984 9.49 DRD2 SLC6A3
23 monoamine transport GO:0015844 9.48 SLC18A2 SLC6A3
24 dopamine transport GO:0015872 9.46 SLC18A2 SLC6A3
25 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.43 HSPD1 SLC18A2
26 negative regulation of dopamine secretion GO:0033602 9.37 CNR1 DRD2
27 negative regulation of blood pressure GO:0045776 9.33 CNR1 DRD2 DRD5
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.32 DRD2 DRD4
29 response to histamine GO:0034776 9.26 DRD2 DRD4
30 response to amphetamine GO:0001975 9.26 DRD2 DRD4 DRD5 SLC18A2
31 response to cocaine GO:0042220 9.02 CNR1 DRD2 DRD5 HSPD1 SLC6A3

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.83 CNR1 DRD2 DRD4 DRD5 HTR7
2 signal transducer activity GO:0004871 9.71 CNR1 DRD2 DRD4 DRD5
3 drug binding GO:0008144 9.46 CNR1 DRD2 DRD4 SLC6A3
4 amino acid binding GO:0016597 9.37 TDO2 TPH2
5 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD2 DRD4
6 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC6A3
7 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD4 DRD5
8 dopamine binding GO:0035240 8.92 DRD2 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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