MCID: TCD001
MIFTS: 48

Tic Disorder malady

Mental diseases, Fetal diseases categories

Summaries for Tic Disorder

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards: Tic Disorder is related to chronic tic disorder and attention deficit hyperactivity disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are GPCRs, Other and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drug clonazepam and the compounds (-)-sulpiride and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and b cells, and related mouse phenotype behavior/neurological.

Wikipedia:66 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Related Diseases for Tic Disorder

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18GeneCards, 19GeneDecks
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Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1chronic tic disorder31.1OFCC1, DRD4, DNAJC13, AKAP17A
2attention deficit hyperactivity disorder30.9TPH2, HTR2A, DRD4, DRD2
3gilles de la tourette syndrome30.8HTR2A, DRD4, DRD2
4obsessive-compulsive disorder30.7TPH2, HTR2A, DRD4, DRD2
5oppositional defiant disorder30.2DRD4
6anxiety disorder30.2TPH2
7schizophrenia30.1TPH2, HTR2A, DRD4, DRD2
8conduct disorder30.1DRD4, DRD2
9migraine30.0HTR2A, DRD4, DRD2
10transient tic disorder10.5
11neuronitis10.2
12trichotillomania10.2
13autism spectrum disorder10.2
14chorea10.2
15blindness10.2
16neuroleptic malignant syndrome10.1DRD2
17pathological gambling10.1DRD2, DRD4
18delusional disorder10.0DRD2, DRD4
19heroin dependence10.0DRD4, DRD2
20substance dependence10.0DRD2, DRD4
21substance abuse10.0DRD4, DRD2
22hyperprolactinemia10.0DRD4, DRD2
23rheumatic fever10.0
24common cold10.0
25arteriovenous malformation10.0
26restless legs syndrome10.0
27fragile x syndrome10.0
28dystonia10.0
29migraine with aura10.0
30motor neuron disease10.0
31acanthocytosis10.0
32childhood-onset schizophrenia10.0
33pandas10.0
34sydenham's chorea10.0
35mental retardation10.0
36ataxia10.0
37tremor10.0
38nicotine dependence10.0DRD2, DRD4
39seasonal affective disorder10.0DRD4, HTR2A
40personality disorder10.0DRD2, DRD4, TPH2
41bipolar disorder10.0DRD2, HTR2A
42antisocial personality disorder10.0DRD2, HTR2A
43schizoaffective disorder10.0DRD2, DRD4, HTR2A
44panic disorder10.0TPH2, HTR2A, DRD4
45alcohol dependence10.0DRD2, DRD4, HTR2A
46narcolepsy10.0DRD2, HTR2A
47anorexia nervosa10.0HTR2A, DRD4
48parkinson's disease9.9DRD2, DRD4, HTR2A
49obesity9.9DRD2, DRD4, HTR2A
50psychotic disorder9.9DRD2, DRD4, HTR2A, TPH2

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Symptoms for Tic Disorder

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Drugs & Therapeutics for Tic Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Tic Disorder

Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Search CenterWatch for Tic Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Tic Disorder

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Anatomical Context for Tic Disorder

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34MalaCards
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MalaCards organs/tissues related to Tic Disorder:

34
Brain, Skin, B cells

Animal Models for Tic Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Tic Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4DRD2, DRD4, HTR2A, TPH2, HSPD1

Publications for Tic Disorder

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Sources:
53PubMed
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Articles related to Tic Disorder:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
2
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. (24343476)
2013
3
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. (23821420)
2013
4
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. (21431421)
2011
5
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. (21241949)
2011
6
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. (20378921)
2011
7
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 A9 2 factorial design study. (21331638)
2011
8
Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. (20143146)
2010
9
Tic Disorder: An Unusual Presentation of Neurotoxoplasmosis in a Patient with AIDS. (21113285)
2010
10
Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder. (21053620)
2010
11
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. (19864199)
2009
12
Aripiprazole treatment in an adolescent patient with chronic motor tic disorder and treatment-resistant obsessive-compulsive disorder. (19706223)
2009
13
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. (19698938)
2009
14
Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. (20035592)
2009
15
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
16
Open label aripiprazole in the treatment of youth with tic disorders. (19702496)
2009
17
Multicenter clinical study on the treatment of children's tic disorder with Qufeng Zhidong Recipe. (19688312)
2009
18
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. (18439116)
2008
19
Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorder. (17896073)
2008
20
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. (17717739)
2008
21
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
22
Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity. (17537072)
2007
23
Plasma kynurenine and related measures in tic disorder patients. (17665285)
2007
24
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. (17171537)
2007
25
An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disorders. (17685747)
2007
26
Candidate locus for chorea and tic disorders at 15q? (17628228)
2007
27
Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats. (17013915)
2006
28
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. (17052389)
2006
29
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. (16536367)
2006
30
A case of adult onset tic disorder following carbon monoxide intoxication. (15198457)
2004
31
Transient tic disorder following carbon monoxide poisoning. (15356451)
2004
32
Association of small life events with self reports of tic severity in pediatric and adult tic disorder patients: a prospective longitudinal study. (15096084)
2004
33
Elevated binding of D8/17-specific monoclonal antibody to B lymphocytes in Tic disorder patients. (15285987)
2004
34
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. (11694329)
2001
35
History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. (11295792)
2001
36
Quetiapine for tic disorder: a case report. (11853307)
2001
37
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
38
Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. (10823299)
2000
39
Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder. (11063087)
2000
40
A functional-analytic approach to the diagnosis of a transient tic disorder. (8959431)
1996
41
Psychotic symptoms and a diagnosis of schizophrenia follow an initial diagnosis of tic disorder. (8973056)
1996
42
Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. (7771914)
1995
43
Tic disorder associated with encephalopathy in advanced HIV disease. (7926707)
1994
44
Nortriptyline treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8428873)
1993
45
Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8444765)
1993
46
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. (8227493)
1993
47
Posttraumatic tic disorder. (2325689)
1990
48
A case of post-traumatic tic disorder. (2682216)
1989
49
Auditory hallucinosis and atypical tic disorder: case reports. (4030705)
1985
50
Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome. (3974894)
1985

Variations for Tic Disorder

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Expression for genes affiliated with Tic Disorder

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for genes affiliated with Tic Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 56Reactome
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Compounds for genes affiliated with Tic Disorder

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Sources:
30IUPHAR, 46Novoseek, 52PharmGKB, 62Tocris Bioscience, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride309.9DRD4, DRD2
2(+)-sulpiride309.9DRD4, DRD2
3eticlopride46 3010.9DRD4, DRD2
4(11c)-n-methylspiperone469.9DRD2, HTR2A
5clotiapine469.9DRD2, HTR2A
6nemonapride46 52 3011.8DRD2, DRD4
7l-741,62662 3010.8HTR2A, DRD2
8amperozide469.8HTR2A, DRD2
9eedq469.8HTR2A, DRD2
10amisulpride46 30 1211.7HTR2A, DRD2
11sch 23390469.7DRD2, DRD4
12molindone30 1210.7HTR2A, DRD2
13aniracetam46 30 1211.6DRD2, HTR2A
14piribedil30 4610.6DRD2, DRD4
15melperone469.6HTR2A, DRD4, DRD2
16(+)-butaclamol46 3010.6DRD2, DRD4, HTR2A
17remoxipride46 1210.6HTR2A, DRD4, DRD2
18loxapine30 46 1211.6HTR2A, DRD4, DRD2
19raclopride46 3010.6DRD2, DRD4, HTR2A
20roxindole30 4610.6HTR2A, DRD4, DRD2
21terguride46 3010.6HTR2A, DRD4, DRD2
22fluphenazine30 46 52 1212.6HTR2A, DRD4, DRD2
23spiperone46 3010.6HTR2A, DRD4, DRD2
24piperazine46 1210.6HTR2A, DRD4, DRD2
25promazine46 1210.6HTR2A, DRD4, DRD2
26ropinirole46 1210.6HTR2A, DRD4, DRD2
27lisuride46 30 1211.6DRD2, DRD4, HTR2A
28paliperidone46 1210.6HTR2A, DRD4, DRD2
29zuclopenthixol46 52 1211.6DRD2, HTR2A
30pergolide46 30 1211.6HTR2A, DRD4, DRD2
31iloperidone52 46 30 1212.6HTR2A, DRD4, DRD2
32pramipexole46 30 52 1212.6HTR2A, DRD4, DRD2
33quinpirole46 3010.5DRD2, DRD4, HTR2A
34asenapine30 1210.5DRD2, DRD4, HTR2A
35cabergoline46 30 1211.5HTR2A, DRD4, DRD2
36aripiprazole30 46 52 25 1213.5DRD2, DRD4, HTR2A
37ziprasidone30 52 46 1212.5DRD2, DRD4, HTR2A
38apomorphine30 46 1211.5HTR2A, DRD4, DRD2
39quetiapine46 52 30 25 1213.5HTR2A, DRD4, DRD2
40bromocriptine46 30 1211.5DRD2, DRD4, HTR2A
41chlorpromazine30 46 52 1212.5DRD2, DRD4, HTR2A
42risperidone46 52 30 62 25 1214.5HTR2A, DRD4, DRD2
43fluoxetine46 52 30 1212.5DRD2, HTR2A, TPH2
44olanzapine46 52 30 25 1213.4DRD2, DRD4, HTR2A
45thiothixene30 1210.4DRD2, HTR2A
46clozapine46 30 52 1212.3HTR2A, DRD4, DRD2
47maoa469.2DRD2, DRD4, HTR2A, TPH2
48fluspirilene30 46 1211.2DRD2, HTR2A
495-hydroxytryptamine469.2TPH2, HTR2A, DRD4, DRD2
50haloperidol46 52 30 3 1213.2HTR2A, DRD4, DRD2

GO Terms for genes affiliated with Tic Disorder

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17Gene Ontology
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Cellular components related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.6DRD2, DRD4

Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:0347769.9DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.9DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:19013869.9DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.9DRD4, DRD2
5behavioral response to ethanolGO:0481499.9DRD2, DRD4
6dopamine metabolic processGO:0424179.8DRD4, DRD2
7negative regulation of protein secretionGO:0507099.8DRD4, DRD2
8synaptic transmission, dopaminergicGO:0019639.8DRD4, DRD2
9arachidonic acid secretionGO:0504829.8DRD2, DRD4
10negative regulation of synaptic transmission, glutamatergicGO:0519679.8HTR2A, DRD2
11negative regulation of adenylate cyclase activityGO:0071949.7DRD2, DRD4
12temperature homeostasisGO:0016599.6DRD2, HTR2A
13release of sequestered calcium ion into cytosolGO:0512099.6HTR2A, DRD2
14response to amphetamineGO:0019759.5DRD2, DRD4
15positive regulation of ERK1 and ERK2 cascadeGO:0703749.5DRD2, HTR2A
16behavioral response to cocaineGO:0481489.5DRD2, DRD4, HTR2A
17circadian rhythmGO:0076239.5DRD4, TPH2
18cellular calcium ion homeostasisGO:0068749.5DRD2, DRD4, HTR2A
19B cell activationGO:0421139.4AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.6DRD2, DRD4
2potassium channel regulator activityGO:0154599.6DRD2, DRD4
3dopamine bindingGO:0352409.3DRD2, DRD4
4drug bindingGO:0081449.1DRD2, DRD4, HTR2A

Products for genes affiliated with Tic Disorder

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Sources for Tic Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet