Aliases & Classifications for Tic Disorder

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder, also known as behavioral tic, is related to schizophrenia and chronic tic disorder, and has symptoms including symptoms, recurrent muscle twitches (symptom) and ataxia. An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Long-term potentiation. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and globus pallidus, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Related Diseases for Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 27.0 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
2 chronic tic disorder 12.4
3 transient tic disorder 12.3
4 gilles de la tourette syndrome 11.9
5 pandas 11.1
6 placenta disease 10.6 DRD2 DRD4
7 antisocial personality disorder 10.5 DRD2 DRD4 SLITRK1
8 c8 deficiency, type ii 10.4 DRD2 DRD4
9 intracranial cavernous angioma 10.4 DRD2 SLC6A3
10 tinea pedis 10.4 SLC6A3 SLITRK1
11 attention deficit-hyperactivity disorder 10.3
12 microcephaly 18, primary, autosomal dominant 10.3 SLC18A2 SLC6A3
13 eosinophilia-myalgia syndrome 10.3 DRD2 DRD4 SLC6A3
14 teebi kaurah syndrome 10.2 DRD2 HTR2A
15 hyperthyroxinemia 10.2 DRD2 HTR2A
16 pompholyx 10.2 DRD2 HTR2A
17 obsessive-compulsive disorder 10.2
18 hypertrophy of breast 10.2 DRD4 SLC6A3
19 laryngeal adductor paralysis 10.1 DRD4 HTR2A TPH2
20 allergic hypersensitivity disease 10.1 DRD2 HTR2A
21 vascular cancer 10.1 DRD2 HTR2A
22 pauci-immune glomerulonephritis with anca 10.1 DRD2 DRD4 HTR2A
23 bladder hepatoid adenocarcinoma 10.1 DRD2 SLC18A2 SLC6A3
24 glucose intolerance 10.1 DRD4 OFCC1
25 hemorrhagic cystitis 10.1 DRD2 DRD4 SLC6A3 TPH2
26 ganglioneuroma 10.0 DRD2 SLC18A2 SLC6A3
27 tongue disease 10.0 DRD2 SLC6A3
28 pervasive developmental disorder 10.0 DRD4 DRD5 SLC6A3
29 sleep apnea 9.9 DRD5 HTR2A
30 tuberculosis 9.9 DRD5 HTR2A
31 splenic abscess 9.9 DRD2 HTR2A SLC6A3
32 trichotillomania 9.9
33 parkinsonism-dystonia, infantile 9.8 DRD2 HTR2A SLC6A3
34 neuronitis 9.8
35 autism spectrum disorder 9.8
36 encephalopathy 9.8
37 carotid stenosis 9.8 DRD2 DRD4 DRD5 SLC6A3
38 heroin dependence 9.8 DRD2 DRD4 DRD5 SLC6A3
39 atrial fibrillation, familial, 10 9.7 HSPD1 HTR2A TPH2
40 intrahepatic gall duct cancer 9.7 HTR2A TPH2
41 pyromania 9.7 DRD2 DRD4 HTR2A SLC6A3
42 hepatic angiomyolipoma 9.7 HTR2A SLC18A2 SLC6A3
43 personality disorder 9.6 DRD2 DRD4 HTR2A SLC6A3
44 scrapie 9.6 DRD2 DRD5 SLC6A3
45 common cold 9.6
46 early-onset schizophrenia 9.6
47 arteriovenous malformation 9.6
48 conduct disorder 9.6
49 huntington disease 9.6
50 rheumatic fever 9.6

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


symptoms, recurrent muscle twitches (symptom), ataxia, athetosis, dystonia, myoclonus, tremor, synkinesis, tic, gestural, tic, transient, tic, motor, tic, vocal

MGI Mouse Phenotypes related to Tic Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 DRD2 DRD4 DRD5 HDC HSPD1 HTR2A
2 nervous system MP:0003631 9.65 HSPD1 SLC18A2 SLC6A3 SLITRK1 TDO2 TPH2
3 taste/olfaction MP:0005394 8.92 DRD2 SLC18A2 SLC6A3 TPH2

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 301)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
9
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
10 Piracetam Approved Phase 4 7491-74-9
11
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
12
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
13
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
14
Dexlansoprazole Approved Phase 4,Phase 3 138530-94-6, 103577-45-3 9578005
15
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
16
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
17
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
18
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
19
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
20
Haloperidol Approved Phase 4 52-86-8 3559
21
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
22
Budesonide Approved Phase 4 51333-22-3 63006 5281004
23
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
24
Amlodipine Approved Phase 4 88150-42-9 2162
25
Codeine Approved, Illicit Phase 4 76-57-3 5284371
26
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
27
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
28
Cycloserine Approved Phase 4 68-41-7 401 6234
29
Flurbiprofen Approved, Investigational Phase 4,Phase 1 5104-49-4 3394
30
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
31
Ondansetron Approved Phase 4 99614-02-5 4595
32
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
33
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
34
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
35
Galantamine Approved Phase 4 357-70-0 9651
36
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
37
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
38 Etiracetam Investigational Phase 4 33996-58-6
39 Anabolic Agents Phase 4
40 Androgens Phase 4
41 Antineoplastic Agents, Hormonal Phase 4
42 Hormone Antagonists Phase 4,Phase 3
43 Hormones Phase 4,Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
45 Pharmaceutical Solutions Phase 4,Phase 3
46 Testosterone 17 beta-cypionate Phase 4
47
Testosterone enanthate Phase 4 315-37-7 9416
48 Testosterone undecanoate Phase 4
49 Adrenergic Agents Phase 4,Phase 3,Phase 2
50 Adrenergic Agonists Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 267)

id Name Status NCT ID Phase Drugs
1 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Unknown status NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
2 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
3 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
5 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4 placebo;extended-release guanfacine (Intuniv)
6 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
8 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
9 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
10 Comparison 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
11 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
12 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4 Magnesium Sulfate;Dexmedetomidine
13 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
14 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
15 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4 Dexmedetomidine;Saline
16 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
17 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
18 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4 S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
19 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
20 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4 Imuneks 10mg
21 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4 Naproxen Sodium Codeine;Placebo
22 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Completed NCT01863459 Phase 4 Lisdexamfetamine Dimesylate;placebo
23 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4 D-Cycloserine;Placebo
24 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
25 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Recruiting NCT02457130 Phase 4 Ticagrelor;Clopidogrel
26 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Recruiting NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
27 Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery Recruiting NCT03172988 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
28 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Active, not recruiting NCT03037606 Phase 4 Rabelis DDR 50 mg Capsules;Pariet 20 mg Enteric Coated Tablets
29 The Safety of Dapoxetine/Tadalafil Combination Therapy Active, not recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
30 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4 galantamine
31 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Unknown status NCT00183391 Phase 3 Atomoxetine;Methylphenidate
32 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
33 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
34 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
35 Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727700 Phase 3 Aripiprazole;Placebo
36 Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727713 Phase 3 Aripiprazole
37 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418352 Phase 3 aripiprazole 52.5 mg;Matching Placebo;Aripiprazole 77.5 mg;Aripiprazole 110 mg
38 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418339 Phase 3 aripiprazole;Placebo
39 Safety & Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01416441 Phase 3 aripiprazole
40 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
41 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
42 An Open-Label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. Completed NCT00206336 Phase 3 Topiramate (drug)
43 A Randomized, Placebo-Controlled, Tourette Syndrome Study. Completed NCT00206323 Phase 3 Topiramate (drug)
44 Long-term Safety and Effectiveness of OROS Methylphenidate HCl in Children With Attention Deficit Hyperactivity Disorder Completed NCT00269815 Phase 3 methylphenidate HCl
45 A Comparison Between Internet Therapy and Group Therapy for Social Phobia - A Trial Using Cognitive Behavioural Therapy Completed NCT00564967 Phase 3
46 A Multicenter Study Comparing the Efficacy and Safety of OROS Methylphenidate HCl, Ritalin (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder Completed NCT00269802 Phase 3 OROS methylphenidate HCl;Ritalin;Placebo
47 Efficacy and Safety Evaluation of Levofloxacin Triple Therapy for Helicobacter Pylori Eradication Completed NCT01131026 Phase 3 Levofloxacin;Amoxicillin;Lansoprazole
48 Efficacy and Safety Study of Udenafil Tablets in Erectile Dysfunction. Completed NCT01305083 Phase 3 Udenafil;Placebo
49 Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery Completed NCT01837290 Phase 3 dexmedetomidine infusion for premedication;Midazolam;saline infusion;Spinal block with hyperbaric bupivacaine 0.5% 12.5 mg
50 Pallidal Stimulation and Gilles de la Tourette Syndrome Completed NCT00478842 Phase 3

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Tic Disorder

Genetic tests related to Tic Disorder:

id Genetic test Affiliating Genes
1 Tics 29

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

39
Brain, Heart, Globus Pallidus, Lung, Testes, Prostate, Thalamus

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 145)
id Title Authors Year
1
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus. ( 28379724 )
2017
2
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
3
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
4
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
5
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
6
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
7
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. ( 28894297 )
2017
8
Pediatric Tourette Syndrome: A Tic Disorder with a Tricky Presentation. ( 28611559 )
2017
9
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
10
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2016
11
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
12
Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial. ( 27579050 )
2016
13
Provisional Tic Disorder: What to tell parents when their child first starts ticcing. ( 27158458 )
2016
14
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ( 27486363 )
2015
15
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
16
Paroxetine-Related Adult-Onset Tic Disorder: A Presentation of Primary Progressive Multiple Sclerosis. ( 26222974 )
2015
17
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
18
Evaluation of cognitive behaviour therapy for paediatric obsessive-compulsive disorder in the context of tic disorders. ( 25843610 )
2015
19
A Case of Atypical Adult-onset Tic Disorder. ( 25888196 )
2015
20
Clinical Characteristics of Pediatric Trichotillomania: Comparisons with Obsessive-Compulsive and Tic Disorders. ( 25894516 )
2015
21
Late onset tic disorder: A rare occurrence. ( 26310263 )
2015
22
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. ( 25020072 )
2014
23
Post-operative Adult Onset Tic Disorder: A Rare Presentation. ( 25336779 )
2014
24
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). ( 24633901 )
2014
25
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
26
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
27
A guide to childhood motor stereotypies, tic disorders and the tourette spectrum for the primary care practitioner. ( 24757265 )
2014
28
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
29
Reward enhances tic suppression in children within months of tic disorder onset. ( 25220075 )
2014
30
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
31
The future of tic disorder treatment. ( 24175754 )
2013
32
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. ( 23821420 )
2013
33
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. ( 23487208 )
2013
34
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
35
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. ( 23140273 )
2013
36
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. ( 24343476 )
2013
37
Clinical Effectiveness of Aripiprazole in Short-term Treatment of Tic Disorder in Children and Adolescents: A Naturalistic Study. ( 23920131 )
2013
38
Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey. ( 23516770 )
2013
39
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. ( 23360517 )
2013
40
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
41
A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia. ( 21915912 )
2012
42
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
43
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
44
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. ( 21431421 )
2011
45
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
46
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 A9 2 factorial design study. ( 21331638 )
2011
47
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. ( 21241949 )
2011
48
The clinical syndrome of primary tic disorder associated with dystonia: a large clinical series and a review of the literature. ( 21506147 )
2011
49
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. ( 20378921 )
2011
50
Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomania. ( 21440858 )
2011

Variations for Tic Disorder

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 DRD2 DRD4 DRD5 SLC18A2 SLC6A3
2
Show member pathways
11.88 DRD2 DRD4 DRD5
3 11.85 HSPD1 HTR2A TPH2
4
Show member pathways
11.65 DRD2 SLC18A2 SLC6A3
5 11.6 HTR2A SLC18A2 TPH2
6
Show member pathways
11.51 DRD2 DRD4 SLC18A2
7
Show member pathways
10.98 DRD2 DRD4 DRD5 HTR2A
8 10.97 SLC18A2 SLC6A3
9
Show member pathways
10.97 SLC6A3 TDO2 TPH2
10 10.83 DRD2 DRD5
11 10.58 HTR2A SLC18A2 TPH2

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
2 non-motile cilium GO:0097730 8.62 DRD2 DRD5

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.7 DRD4 DRD5 HTR2A
2 locomotory behavior GO:0007626 9.69 DRD2 SLC18A2 SLC6A3
3 positive regulation of multicellular organism growth GO:0040018 9.65 DRD2 SLC6A3
4 negative regulation of adenylate cyclase activity GO:0007194 9.65 DRD2 DRD4
5 negative regulation of blood pressure GO:0045776 9.64 DRD2 DRD5
6 adult behavior GO:0030534 9.64 DRD2 SLITRK1
7 associative learning GO:0008306 9.63 DRD2 DRD5
8 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD4
9 regulation of dopamine secretion GO:0014059 9.62 DRD2 HTR2A
10 temperature homeostasis GO:0001659 9.62 DRD2 HTR2A
11 response to iron ion GO:0010039 9.61 DRD2 SLC6A3
12 synaptic transmission, dopaminergic GO:0001963 9.61 DRD2 DRD5
13 negative regulation of protein secretion GO:0050709 9.6 DRD2 DRD4
14 behavioral response to ethanol GO:0048149 9.59 DRD2 DRD4
15 positive regulation of kinase activity GO:0033674 9.58 DRD4 HTR2A
16 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.58 DRD2 HTR2A
17 dopamine metabolic process GO:0042417 9.57 DRD2 DRD4
18 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.56 DRD2 DRD5
19 negative regulation of voltage-gated calcium channel activity GO:1901386 9.55 DRD2 DRD4
20 prepulse inhibition GO:0060134 9.54 DRD2 SLC6A3
21 response to cocaine GO:0042220 9.54 DRD2 DRD5 SLC6A3
22 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.49 DRD2 DRD4
23 regulation of dopamine metabolic process GO:0042053 9.48 DRD4 SLC6A3
24 adenohypophysis development GO:0021984 9.46 DRD2 SLC6A3
25 monoamine transport GO:0015844 9.43 SLC18A2 SLC6A3
26 dopamine transport GO:0015872 9.4 SLC18A2 SLC6A3
27 behavioral response to cocaine GO:0048148 9.33 DRD2 DRD4 HTR2A
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.32 DRD2 DRD4
29 response to histamine GO:0034776 9.26 DRD2 DRD4
30 dopamine receptor signaling pathway GO:0007212 8.96 DRD2 DRD4
31 response to amphetamine GO:0001975 8.92 DRD2 DRD4 DRD5 SLC18A2

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 DRD2 DRD4 DRD5 HTR2A
2 drug binding GO:0008144 9.46 DRD2 DRD4 HTR2A SLC6A3
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD2 DRD4
4 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC6A3
5 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD4 DRD5
6 dopamine binding GO:0035240 8.92 DRD2 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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