MCID: TCD001
MIFTS: 38

Tic Disorder malady

Neuronal category

Summaries for Tic Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards: Tic Disorder is related to attention deficit hyperactivity disorder and obsessive-compulsive disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Hypothetical Network for Drug Addiction and Dopamine receptors. The drug clonazepam and the compounds Thiethylperazine and (-)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia:64 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Related Diseases for Tic Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.0TPH2, DRD4, DRD2, HTR2A
2obsessive-compulsive disorder30.8HTR2A, DRD2, DRD4, TPH2
3chronic tic disorder30.5DNAJC13, AKAP17A, OFCC1, DRD4
4gilles de la tourette syndrome30.4DRD4, DRD2, HTR2A
5anxiety disorder30.4HTR2A, DRD2, TPH2
6restless legs syndrome30.0DRD2
7parkinson's disease30.0HTR2A, DRD2, DRD4
8transient tic disorder10.3
9trichotillomania10.2
10n syndrome10.2
11autism spectrum disorder10.2
12chorea10.2
13rheumatic fever10.0
14arteriovenous malformation10.0
15asperger syndrome10.0
16pain disorder10.0
17conduct disorder10.0
18common cold10.0
19adult syndrome10.0
20sleep disorder10.0
21withdrawal disorder10.0
22short syndrome10.0
23acanthocytosis10.0
24childhood-onset schizophrenia10.0
25pandas10.0
26sydenham's chorea10.0
27mental retardation10.0
28ataxia10.0
29tremor10.0
30autistic disorder10.0DRD4
31cocaine dependence10.0DRD2
32alcohol abuse10.0DRD2
33myoclonus-dystonia10.0DRD2
34bulimia nervosa10.0HTR2A
35neuroleptic malignant syndrome10.0DRD2
36heroin dependence10.0DRD2, DRD4
37hyperprolactinemia10.0DRD4, DRD2
38ischemia10.0DRD2
39delusional disorder10.0DRD4, DRD2
40nicotine dependence10.0DRD2, DRD4
41pathological gambling10.0DRD4, DRD2
42anorexia nervosa10.0DRD4, HTR2A
43seasonal affective disorder10.0DRD4, HTR2A
44antisocial personality disorder10.0HTR2A, DRD2
45substance dependence10.0DRD4, DRD2
46personality disorder10.0TPH2, DRD4, DRD2
47alcohol dependence10.0DRD4, DRD2, HTR2A
48migraine10.0DRD4, DRD2, HTR2A
49panic disorder10.0HTR2A, DRD4, TPH2
50schizoaffective disorder10.0DRD4, DRD2, HTR2A

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Clinical Features for Tic Disorder

Drugs & Therapeutics for Tic Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Tic Disorder

Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Search CenterWatch for Tic Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Tic Disorder

Anatomical Context for Tic Disorder

Sources:
33MalaCards
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MalaCards organs/tissues related to Tic Disorder:

33
Brain

Animal Models for Tic Disorder or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Tic Disorder

Sources:
51PubMed
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Articles related to Tic Disorder:

(show all 18)
idTitleAuthorsYear
1
Pharmacotherapeutic challenges in the management of attention-deficit/hyperactivity disorder and chronic tics in a school aged child. (24251645)
2013
2
The effects of awareness training on tics in a young boy with Tourette syndrome, Asperger syndrome, and attention deficit hyperactivity disorder. (24114235)
2013
3
Type IIB thyroplasty for phonic tics in a pediatric patient with autism spectrum disorder: a case report. (23406841)
2013
4
Pachydermodactyly in a Patient With Generalized Anxiety Disorder and Tics. (24238330)
2013
5
Exacerbation of obsessive-compulsive disorder, generalized anxiety disorder, and chronic motor tics during treatment of attention-deficit/hyperactivity disorder: medication management in an older adolescent. (24138012)
2013
6
Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics. (20610993)
2010
7
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. (19582565)
2009
8
Neuropsychiatric-developmental model for the expression of tics, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS. (18609435)
2009
9
Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. (19120712)
2008
10
Treatment-resistant self-mutilation, tics, and obsessive-compulsive disorder in neuroacanthocytosis: a mouth guard as a therapeutic approach. (18687019)
2008
11
Clinical significance of tics and attention-deficit hyperactivity disorder (ADHD) in children with pervasive developmental disorder. (15996396)
2005
12
The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. (15060240)
2004
13
Cytogenetic disorders in peripheral blood lymphocytes of patients with febrile form of tick-borne encephalitis. (15085248)
2004
14
Occurrence of tics in Asperger's syndrome and autistic disorder. (10868783)
2000
15
Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder]. (9842133)
1998
16
Hyperkinetic movement disorders misdiagnosed as tics in Gilles de la Tourette syndrome. (9613740)
1998
17
Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. (9280153)
1997
18
Ticks, Acarina-Ixodoidea, in the causation of animal disorders and as vectors of disease, with some observations on relapsing fever in California. (18872990)
1948

Genetic Variations for Tic Disorder

Expression for genes affiliated with Tic Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for genes affiliated with Tic Disorder

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB
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Pathways related to Tic Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DRD4, DRD2
29.8DRD4, DRD2
3
Hide members
9.4DRD4, DRD2, HTR2A
49.2HSPD1, HTR2A, TPH2

Compounds for genes affiliated with Tic Disorder

Sources:
11DrugBank, 29IUPHAR, 45Novoseek, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1Thiethylperazine1110.1DRD4, DRD2
2(-)-sulpiride2910.1DRD4, DRD2
3(+)-sulpiride2910.1DRD2, DRD4
4(11c)-n-methylspiperone4510.1DRD2, HTR2A
5clotiapine4510.1HTR2A, DRD2
6l-741,62660 2911.0HTR2A, DRD2
7Mesoridazine1110.0HTR2A, DRD2
8eticlopride29 4511.0DRD2, DRD4
9eedq459.9DRD2, HTR2A
10amperozide459.9DRD2, HTR2A
11melperone459.9DRD2, HTR2A, DRD4
12(+)-butaclamol29 4510.8DRD2, DRD4, HTR2A
13loxapine29 45 1111.8DRD2, DRD4, HTR2A
14remoxipride45 1110.8DRD4, DRD2, HTR2A
15raclopride45 2910.8DRD2, DRD4, HTR2A
16roxindole29 4510.8DRD2, HTR2A, DRD4
17terguride29 4510.8HTR2A, DRD2, DRD4
18amisulpride45 29 1111.8HTR2A, DRD2
19fluphenazine29 45 1111.8DRD4, HTR2A, DRD2
20Propiomazine119.8HTR2A, DRD2, DRD4
21spiperone29 4510.8DRD4, DRD2, HTR2A
22piperazine45 1110.8DRD2, DRD4, HTR2A
23ropinirole45 1110.8DRD4, DRD2, HTR2A
24promazine45 1110.8HTR2A, DRD2, DRD4
25lisuride29 45 1111.8DRD4, DRD2, HTR2A
26pergolide29 45 1111.8HTR2A, DRD4, DRD2
27paliperidone45 1110.8DRD4, DRD2, HTR2A
28pramipexole45 50 29 1112.8HTR2A, DRD2, DRD4
29iloperidone50 45 29 1112.8DRD2, DRD4, HTR2A
30Methotrimeprazine119.8HTR2A, DRD2, DRD4
31quinpirole45 2910.8DRD4, DRD2, HTR2A
32molindone29 1110.8HTR2A, DRD2
33asenapine29 1110.8DRD4, HTR2A, DRD2
34cabergoline29 45 1111.8DRD4, HTR2A, DRD2
35aripiprazole29 50 45 11 2413.8HTR2A, DRD4, DRD2
36ziprasidone50 29 45 1112.8HTR2A, DRD4, DRD2
37apomorphine45 29 1111.8HTR2A, DRD2, DRD4
38quetiapine45 50 29 11 2413.7DRD2, DRD4, HTR2A
39risperidone29 45 50 60 11 2414.7DRD4, DRD2, HTR2A
40zuclopenthixol45 50 1111.7HTR2A, DRD2
41nemonapride50 45 2911.7DRD2, DRD4
42bromocriptine29 45 1111.7DRD2, HTR2A, DRD4
43chlorpromazine45 29 50 1112.7HTR2A, DRD2, DRD4
44olanzapine50 45 29 11 2413.5DRD2, DRD4, HTR2A
45trifluoperazine45 29 1111.5ACP1, DRD2, HTR2A
46fluoxetine50 45 29 1112.5TPH2, DRD2, HTR2A
47aniracetam29 45 1111.4HTR2A, DRD2
48maoa459.4HTR2A, TPH2, DRD4, DRD2
495-hydroxytryptamine459.3HTR2A, TPH2, DRD4, DRD2
50norepinephrine45 11 2410.9ACP1, DRD4, DRD2, HTR2A

GO Terms for genes affiliated with Tic Disorder

Sources:
16Gene Ontology
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Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.1DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.1DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:190138610.1DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD2
5behavioral response to ethanolGO:04814910.1DRD4, DRD2
6dopamine metabolic processGO:04241710.0DRD2, DRD4
7negative regulation of protein secretionGO:05070910.0DRD2, DRD4
8behavioral response to cocaineGO:04814810.0DRD2, DRD4
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A
10synaptic transmission, dopaminergicGO:00196310.0DRD2, DRD4
11regulation of dopamine secretionGO:0140599.9HTR2A, DRD2
12arachidonic acid secretionGO:0504829.9DRD4, DRD2
13negative regulation of adenylate cyclase activityGO:0071949.8DRD4, DRD2
14response to amphetamineGO:0019759.8DRD4, DRD2
15temperature homeostasisGO:0016599.8HTR2A, DRD2
16cellular calcium ion homeostasisGO:0068749.7HTR2A, DRD2, DRD4
17release of sequestered calcium ion into cytosolGO:0512099.6DRD2, HTR2A
18B cell activationGO:0421139.3AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.8DRD4, DRD2
2potassium channel regulator activityGO:0154599.8DRD4, DRD2
3dopamine bindingGO:0352409.5DRD4, DRD2
4drug bindingGO:0081449.3DRD4, DRD2, HTR2A

Products for genes affiliated with Tic Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tic Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet