MCID: TCD001
MIFTS: 46

Tic Disorder malady

Neuronal diseases category

Summaries for Tic Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards: Tic Disorder is related to chronic tic disorder and attention deficit hyperactivity disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Hypothetical Network for Drug Addiction and Dopamine receptors. The drug clonazepam and the compounds Thiethylperazine and (-)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and b cells.

Wikipedia:63 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Tic Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1chronic tic disorder31.2OFCC1, AKAP17A, DNAJC13, DRD4
2attention deficit hyperactivity disorder31.0HTR2A, DRD2, TPH2, DRD4
3obsessive-compulsive disorder30.8HTR2A, DRD2, DRD4, TPH2
4gilles de la tourette syndrome30.7DRD4, HTR2A, DRD2
5anxiety disorder30.4TPH2, DRD2, HTR2A
6schizophrenia30.1DRD2, DRD4, TPH2, HTR2A
7restless legs syndrome29.9DRD2
8migraine29.9HTR2A, DRD2, DRD4
9psychotic disorder29.9HTR2A, DRD2, DRD4, TPH2
10transient tic disorder10.5
11trichotillomania10.1
12neuronitis10.1
13autism spectrum disorder10.1
14rheumatic fever10.0
15arteriovenous malformation10.0
16pain disorder10.0
17conduct disorder10.0
18common cold10.0
19adult syndrome10.0
20fragile x syndrome10.0
21migraine with aura10.0
22motor neuron disease10.0
23sleep disorder10.0
24withdrawal disorder10.0
25image syndrome10.0
26autistic disorder10.0DRD4
27cocaine dependence10.0DRD2
28alcohol abuse10.0DRD2
29myoclonus-dystonia10.0DRD2
30bulimia nervosa10.0HTR2A
31neuroleptic malignant syndrome10.0DRD2
32heroin dependence10.0DRD4, DRD2
33hyperprolactinemia10.0DRD4, DRD2
34ischemia10.0DRD2
35delusional disorder10.0DRD2, DRD4
36nicotine dependence10.0DRD4, DRD2
37pathological gambling10.0DRD2, DRD4
38anorexia nervosa10.0HTR2A, DRD4
39seasonal affective disorder10.0HTR2A, DRD4
40antisocial personality disorder10.0HTR2A, DRD2
41substance dependence10.0DRD4, DRD2
42personality disorder10.0DRD4, TPH2, DRD2
43alcohol dependence10.0DRD4, HTR2A, DRD2
44panic disorder10.0HTR2A, TPH2, DRD4
45schizoaffective disorder10.0DRD4, HTR2A, DRD2
46type 1 diabetes10.0ACP1, HSPD1
47parkinson's disease10.0DRD4, DRD2, HTR2A
48mood disorder10.0DRD2, DRD4, TPH2, HTR2A
49bipolar disorder10.0DRD2, TPH2, DRD4, HTR2A
50type 2 diabetes mellitus10.0DRD2, ACP1, HTR2A

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Clinical Features for Tic Disorder

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Drugs & Therapeutics for Tic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tic Disorder

Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Search CenterWatch for Tic Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tic Disorder

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Anatomical Context for Tic Disorder

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32MalaCards
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MalaCards organs/tissues related to Tic Disorder:

32
Brain, Skin, B cells

Animal Models for Tic Disorder or affiliated genes

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Publications for Tic Disorder

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Sources:
50PubMed
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Articles related to Tic Disorder:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. (24138188)
2014
2
Lamotrigine-induced facial tic in a pediatric bipolar disorder patient. (24138013)
2013
3
Clinical Effectiveness of Aripiprazole in Short-term Treatment of Tic Disorder in Children and Adolescents: A Naturalistic Study. (23920131)
2013
4
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. (23487208)
2013
5
Tic and Obsessive Compulsive Disorder: Two Common ADHD Co-morbidities. (23723560)
2012
6
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. (22214315)
2012
7
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. (21431421)
2011
8
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 A9 2 factorial design study. (21331638)
2011
9
The clinical syndrome of primary tic disorder associated with dystonia: a large clinical series and a review of the literature. (21506147)
2011
10
Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomania. (21440858)
2011
11
Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics. (20610993)
2010
12
A proper name for chronic tic disorder. (20889671)
2010
13
Aripiprazole treatment in an adolescent patient with chronic motor tic disorder and treatment-resistant obsessive-compulsive disorder. (19706223)
2009
14
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. (19698938)
2009
15
Multicenter clinical study on the treatment of children's tic disorder with Qufeng Zhidong Recipe. (19688312)
2009
16
Chronic motor tic disorder and aripiprazole. (19622695)
2009
17
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. (19582565)
2009
18
Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorder. (17896073)
2008
19
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. (17717739)
2008
20
Obsessive-compulsive disorder with and without tic disorder: a comparative study from India. (18704026)
2008
21
Fragile X syndrome associated with tic disorders. (18383111)
2008
22
Candidate locus for chorea and tic disorders at 15q? (17628228)
2007
23
Immediate-release methylphenidate for ADHD in children with comorbid chronic multiple tic disorder. (17581448)
2007
24
Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats. (17013915)
2006
25
Association of common cold with exacerbations in pediatric but not adult patients with tic disorder: a prospective longitudinal study. (15910212)
2005
26
Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorder. (15995031)
2005
27
Elevated binding of D8/17-specific monoclonal antibody to B lymphocytes in Tic disorder patients. (15285987)
2004
28
Neuropsychologic characteristics of children with attention-deficit hyperactivity disorder (ADHD), learning disorder, and tic disorder on the Rey-Osterreith Complex Figure. (14736077)
2003
29
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. (11694329)
2001
30
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. (11303888)
2001
31
Comparative study of the behavioral and neuropsychologic characteristics of tic disorder with or without attention-deficit hyperactivity disorder (ADHD). (11669344)
2001
32
Children with comorbid attention-deficit-hyperactivity disorder and tic disorder: evidence for additive inhibitory deficits within the motor system. (11261515)
2001
33
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
34
Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder. (11063087)
2000
35
Lamotrigine-induced tic disorder: report of five pediatric cases. (10897158)
2000
36
Stimulant medication withdrawal during long-term therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. (10103294)
1999
37
Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder]. (9842133)
1998
38
Hyperkinetic movement disorders misdiagnosed as tics in Gilles de la Tourette syndrome. (9613740)
1998
39
Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics. (9280153)
1997
40
Children with ADHD and tic disorder and their classmates: behavioral normalization with methylphenidate. (9136493)
1997
41
A functional-analytic approach to the diagnosis of a transient tic disorder. (8959431)
1996
42
Psychotic symptoms and a diagnosis of schizophrenia follow an initial diagnosis of tic disorder. (8973056)
1996
43
Associated psychopathology in children with both ADHD and chronic tic disorder. (8973069)
1996
44
Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. (7771914)
1995
45
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. (8038934)
1994
46
Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8444765)
1993
47
Posttraumatic tic disorder. (2325689)
1990
48
Pain in Gilles de la Tourette syndrome and related tic disorders. (2804807)
1989
49
Transient tic disorder and the spectrum of Tourette's syndrome. (3190500)
1988
50
Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome. (3974894)
1985

Genetic Variations for Tic Disorder

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Expression for genes affiliated with Tic Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tic Disorder

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Pathways for genes affiliated with Tic Disorder

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB
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Pathways related to Tic Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DRD4, DRD2
29.8DRD4, DRD2
3
Hide members
9.4DRD4, DRD2, HTR2A
49.2HSPD1, HTR2A, TPH2

Compounds for genes affiliated with Tic Disorder

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Sources:
11DrugBank, 28IUPHAR, 44Novoseek, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1Thiethylperazine1110.1DRD4, DRD2
2(-)-sulpiride2810.1DRD4, DRD2
3(+)-sulpiride2810.1DRD2, DRD4
4(11c)-n-methylspiperone4410.1DRD2, HTR2A
5clotiapine4410.1HTR2A, DRD2
6l-741,62659 2811.0HTR2A, DRD2
7Mesoridazine1110.0HTR2A, DRD2
8eticlopride28 4411.0DRD2, DRD4
9eedq449.9DRD2, HTR2A
10amperozide449.9DRD2, HTR2A
11melperone449.9DRD2, HTR2A, DRD4
12(+)-butaclamol28 4410.8DRD2, DRD4, HTR2A
13loxapine28 44 1111.8DRD2, DRD4, HTR2A
14remoxipride44 1110.8DRD4, DRD2, HTR2A
15raclopride44 2810.8DRD2, DRD4, HTR2A
16roxindole28 4410.8DRD2, HTR2A, DRD4
17terguride28 4410.8HTR2A, DRD2, DRD4
18amisulpride44 28 1111.8HTR2A, DRD2
19fluphenazine28 44 1111.8DRD4, HTR2A, DRD2
20Propiomazine119.8HTR2A, DRD2, DRD4
21spiperone28 4410.8DRD4, DRD2, HTR2A
22piperazine44 1110.8DRD2, DRD4, HTR2A
23ropinirole44 1110.8DRD4, DRD2, HTR2A
24promazine44 1110.8HTR2A, DRD2, DRD4
25lisuride28 44 1111.8DRD4, DRD2, HTR2A
26pergolide28 44 1111.8HTR2A, DRD4, DRD2
27paliperidone44 1110.8DRD4, DRD2, HTR2A
28pramipexole44 49 28 1112.8HTR2A, DRD2, DRD4
29iloperidone49 44 28 1112.8DRD2, DRD4, HTR2A
30Methotrimeprazine119.8HTR2A, DRD2, DRD4
31quinpirole44 2810.8DRD4, DRD2, HTR2A
32molindone28 1110.8HTR2A, DRD2
33asenapine28 1110.8DRD4, HTR2A, DRD2
34cabergoline28 44 1111.8DRD4, HTR2A, DRD2
35aripiprazole28 49 44 11 2413.8HTR2A, DRD4, DRD2
36ziprasidone49 28 44 1112.8HTR2A, DRD4, DRD2
37apomorphine44 28 1111.8HTR2A, DRD2, DRD4
38quetiapine44 49 28 11 2413.7DRD2, DRD4, HTR2A
39risperidone28 44 49 59 11 2414.7DRD4, DRD2, HTR2A
40zuclopenthixol44 49 1111.7HTR2A, DRD2
41nemonapride49 44 2811.7DRD2, DRD4
42bromocriptine28 44 1111.7DRD2, HTR2A, DRD4
43chlorpromazine44 28 49 1112.7HTR2A, DRD2, DRD4
44olanzapine49 44 28 11 2413.5DRD2, DRD4, HTR2A
45trifluoperazine44 28 1111.5ACP1, DRD2, HTR2A
46fluoxetine49 44 28 1112.5TPH2, DRD2, HTR2A
47aniracetam28 44 1111.4HTR2A, DRD2
48maoa449.4HTR2A, TPH2, DRD4, DRD2
495-hydroxytryptamine449.3HTR2A, TPH2, DRD4, DRD2
50norepinephrine44 11 2410.9ACP1, DRD4, DRD2, HTR2A

GO Terms for genes affiliated with Tic Disorder

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16Gene Ontology
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Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.1DRD4, DRD2
2positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.1DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:190138610.1DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.1DRD4, DRD2
5behavioral response to ethanolGO:04814910.1DRD4, DRD2
6dopamine metabolic processGO:04241710.0DRD2, DRD4
7negative regulation of protein secretionGO:05070910.0DRD2, DRD4
8behavioral response to cocaineGO:04814810.0DRD2, DRD4
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A
10synaptic transmission, dopaminergicGO:00196310.0DRD2, DRD4
11regulation of dopamine secretionGO:0140599.9HTR2A, DRD2
12arachidonic acid secretionGO:0504829.9DRD4, DRD2
13negative regulation of adenylate cyclase activityGO:0071949.8DRD4, DRD2
14response to amphetamineGO:0019759.8DRD4, DRD2
15temperature homeostasisGO:0016599.8HTR2A, DRD2
16cellular calcium ion homeostasisGO:0068749.7HTR2A, DRD2, DRD4
17release of sequestered calcium ion into cytosolGO:0512099.6DRD2, HTR2A
18B cell activationGO:0421139.3AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.8DRD4, DRD2
2potassium channel regulator activityGO:0154599.8DRD4, DRD2
3dopamine bindingGO:0352409.5DRD4, DRD2
4drug bindingGO:0081449.3DRD4, DRD2, HTR2A

Products for genes affiliated with Tic Disorder

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Sources for Tic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet