Aliases & Classifications for Tic Disorder

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder, also known as behavioral tic, is related to chronic tic disorder and gilles de la tourette syndrome, and has symptoms including recurrent muscle twitches (symptom), symptoms and tic, vocal. An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Long-term potentiation. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and globus pallidus, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 chronic tic disorder 33.8 DRD4 OFCC1
2 gilles de la tourette syndrome 31.8 DRD2 DRD4 DRD5 HDC IMMP2L SLC6A3
3 anxiety 29.9 HTR2A SLC6A3 TPH2
4 early-onset schizophrenia 29.7 DRD2 DRD4 HTR2A
5 oppositional defiant disorder 29.6 DRD2 DRD4 SLC6A3 TPH2
6 obsessive-compulsive disorder 29.6 DRD2 DRD4 HTR2A SLC6A3 SLITRK1 TPH2
7 conduct disorder 29.3 DRD2 DRD4 DRD5 SLC6A3
8 autism spectrum disorder 28.9 DRD2 DRD4 HTR2A IMMP2L SLC6A3 TPH2
9 autism 28.9 DRD2 DRD4 HTR2A IMMP2L TDO2 TPH2
10 attention deficit-hyperactivity disorder 28.9 DRD2 DRD4 DRD5 HTR2A IMMP2L SLC18A2
11 migraine with or without aura 1 28.7 DRD2 DRD4 DRD5 HTR2A SLC6A3
12 schizophrenia 28.0 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
13 transient tic disorder 12.5
14 pandas 11.2
15 delusional disorder 10.4 DRD2 DRD4
16 alcohol-induced mental disorder 10.3 DRD2 SLC6A3
17 impulse control disorder 10.3 DRD2 DRD4 SLITRK1
18 striatonigral degeneration 10.2 DRD2 SLC6A3
19 tardive dyskinesia 10.2 DRD2 HTR2A
20 heroin dependence 10.2 DRD2 DRD4 SLC6A3
21 periodic limb movement disorder 10.2 DRD2 HTR2A
22 bruxism 10.1 DRD2 HTR2A
23 separation anxiety disorder 10.1 DRD4 SLC6A3
24 cocaine abuse 10.1 DRD2 SLC18A2 SLC6A3
25 drug-induced mental disorder 10.1 DRD2 HTR2A
26 movement disease 10.1 DRD2 SLC18A2 SLC6A3
27 drug psychosis 10.0 DRD2 HTR2A
28 specific developmental disorder 10.0 DRD4 DRD5 SLC6A3
29 cranio-facial dystonia 10.0 DRD5 HTR2A
30 antisocial personality disorder 10.0 DRD2 SLC6A3
31 lymphedema, hereditary, ii 10.0 DRD5 HTR2A
32 alcoholic psychosis 10.0 DRD2 HTR2A SLC6A3
33 trichotillomania 9.9
34 tobacco addiction 9.9 DRD2 HTR2A SLC6A3
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
36 chorea, childhood-onset, with psychomotor retardation 9.9
37 choreatic disease 9.9
38 neuronitis 9.9
39 encephalopathy 9.9
40 central nervous system disease 9.8 HTR2A SLC18A2 SLC6A3
41 substance dependence 9.8 DRD2 DRD4 DRD5 SLC6A3
42 pathological gambling 9.8 DRD2 DRD4 HTR2A SLC6A3
43 disease of mental health 9.8 DRD2 DRD4 HTR2A SLC6A3
44 blood group, i system 9.7
45 multiple sclerosis 9.7
46 hashimoto thyroiditis 9.7
47 huntington disease 9.7
48 rheumatic fever-related antigen 9.7
49 mental retardation, x-linked 23 9.7
50 fragile x syndrome 9.7

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


recurrent muscle twitches (symptom), symptoms, tic, vocal, tic, motor, tic, transient, tic, gestural, synkinesis, tremor, myoclonus, dystonia, athetosis, ataxia

MGI Mouse Phenotypes related to Tic Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 DRD2 DRD4 DRD5 HDC HSPD1 HTR2A
2 nervous system MP:0003631 9.65 DRD2 DRD4 DRD5 HDC HSPD1 SLC18A2
3 taste/olfaction MP:0005394 8.92 DRD2 SLC18A2 SLC6A3 TPH2

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Clonidine Approved Phase 4 4205-90-7 2803
5
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
6
Dopamine Approved Phase 4,Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
7 Piracetam Approved, Investigational Phase 4 7491-74-9
8
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
9
Methyltestosterone Approved Phase 4 58-18-4 6010
10
Testosterone Approved, Investigational Phase 4 58-22-0 6013
11
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
13
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 138530-94-6, 103577-45-3 9578005
14
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
15
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
17
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
18
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
19
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 5324346 3404
20
Haloperidol Approved Phase 4 52-86-8 3559
21
Amlodipine Approved Phase 4 88150-42-9 2162
22
Budesonide Approved Phase 4 51333-22-3 5281004 63006
23
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
24
Codeine Approved, Illicit Phase 4 76-57-3 5284371
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
26
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
27
Cycloserine Approved Phase 4 68-41-7 6234 401
28
Flurbiprofen Approved, Investigational Phase 4,Phase 1 5104-49-4 3394
29
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
30
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
31
Ondansetron Approved Phase 4 99614-02-5 4595
32
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
33
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
34
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
35
Cefdinir Approved Phase 4 91832-40-5 6915944
36
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
37
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
38
Doxofylline Approved, Investigational Phase 4 69975-86-6
39
Theophylline Approved Phase 4 58-55-9 2153
40
Galantamine Approved Phase 4 357-70-0 9651
41
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
42
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
43 Etiracetam Investigational Phase 4 33996-58-6
44 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Adrenergic Agonists Phase 4,Phase 3
46 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
47 Adrenergic alpha-Agonists Phase 4,Phase 3
48 Analgesics Phase 4,Phase 3,Phase 1
49 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1
50 Anesthetics Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 282)

# Name Status NCT ID Phase Drugs
1 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
2 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
3 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
4 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4 placebo;extended-release guanfacine (Intuniv)
5 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
6 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Completed NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
8 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
9 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
10 Comparison of 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
11 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
12 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4 Magnesium Sulfate;Dexmedetomidine
13 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
14 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
15 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4 Dexmedetomidine;Saline
16 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4 S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
17 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
18 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Completed NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
19 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
20 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
21 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4 Imuneks 10mg
22 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4 Naproxen Sodium Codeine;Placebo
23 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Completed NCT01863459 Phase 4 Lisdexamfetamine Dimesylate;placebo
24 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4 D-Cycloserine;Placebo
25 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
26 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Recruiting NCT02457130 Phase 4 Ticagrelor;Clopidogrel
27 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults Recruiting NCT03400735 Phase 4 Cefdinir 300Mg Capsule
28 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
29 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Recruiting NCT03037606 Phase 4 Rabelis DDR 50 mg Capsules;Pariet 20 mg Enteric Coated Tablets
30 Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery Recruiting NCT03172988 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
31 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
32 Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment Not yet recruiting NCT03395002 Phase 4 Tiotropium/Salmeterol/Fluticasone 9/50/500 mcg Inhalation Powder;Tiotropium 18 mcg Inhalation Powder;Salmeterol/Fluticasone 50/500 mcg Inhalation Powder
33 Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD. Not yet recruiting NCT03388853 Phase 4 Acetylcysteine/Doxofylline
34 Salmeterol/Fluticasone 50/500 mcg Inhalation Powder Via Capsair vs Seretide Diskus 500 mcg Inhalation Powder in Patients With COPD Not yet recruiting NCT03363503 Phase 4 Salmeterol/Fluticasone Capsair®;Salmeterol/Fluticasone Diskus®
35 Cardiac Safety of Lansoprazole and Domperidon Combination Not yet recruiting NCT03355170 Phase 4 Lansoprazole
36 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4 galantamine
37 Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections) Unknown status NCT01281969 Phase 3 Gamunex Intravenous Immunoglobulin;Placebo
38 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Unknown status NCT00183391 Phase 3 Atomoxetine;Methylphenidate
39 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
40 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
41 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
42 Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727700 Phase 3 Aripiprazole;Placebo
43 Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727713 Phase 3 Aripiprazole
44 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418352 Phase 3 aripiprazole 52.5 mg;Matching Placebo;Aripiprazole 77.5 mg;Aripiprazole 110 mg
45 Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01418339 Phase 3 aripiprazole;Placebo
46 A Randomized, Placebo-controlled, Tourette Syndrome Study. Completed NCT00206323 Phase 3 Topiramate (drug);placebo/sugar pill
47 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
48 Safety & Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01416441 Phase 3 aripiprazole
49 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
50 An Open-label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. Completed NCT00206336 Phase 3 Topiramate (drug)

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Tic Disorder

Genetic tests related to Tic Disorder:

# Genetic test Affiliating Genes
1 Tics 28

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

38
Brain, Testes, Globus Pallidus, Lung, Prostate, Thalamus, Bone

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 146)
# Title Authors Year
1
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
2
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
3
Pediatric Tourette Syndrome: A Tic Disorder with a Tricky Presentation. ( 28611559 )
2017
4
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
5
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
6
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
7
Chronic recurrent dislocation of the temporomandibular joint secondary to a complex facial tic disorder. ( 29017736 )
2017
8
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
9
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. ( 28894297 )
2017
10
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus. ( 28379724 )
2017
11
Provisional Tic Disorder: What to tell parents when their child first starts ticcing. ( 27158458 )
2016
12
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2016
13
Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial. ( 27579050 )
2016
14
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
15
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ( 27486363 )
2015
16
Evaluation of cognitive behaviour therapy for paediatric obsessive-compulsive disorder in the context of tic disorders. ( 25843610 )
2015
17
Late onset tic disorder: A rare occurrence. ( 26310263 )
2015
18
Paroxetine-Related Adult-Onset Tic Disorder: A Presentation of Primary Progressive Multiple Sclerosis. ( 26222974 )
2015
19
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
20
Clinical Characteristics of Pediatric Trichotillomania: Comparisons with Obsessive-Compulsive and Tic Disorders. ( 25894516 )
2015
21
A Case of Atypical Adult-onset Tic Disorder. ( 25888196 )
2015
22
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
23
Post-operative Adult Onset Tic Disorder: A Rare Presentation. ( 25336779 )
2014
24
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
25
A guide to childhood motor stereotypies, tic disorders and the tourette spectrum for the primary care practitioner. ( 24757265 )
2014
26
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). ( 24633901 )
2014
27
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
28
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. ( 25020072 )
2014
29
Reward enhances tic suppression in children within months of tic disorder onset. ( 25220075 )
2014
30
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
31
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
32
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. ( 23360517 )
2013
33
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. ( 24343476 )
2013
34
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. ( 23821420 )
2013
35
Clinical Effectiveness of Aripiprazole in Short-term Treatment of Tic Disorder in Children and Adolescents: A Naturalistic Study. ( 23920131 )
2013
36
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. ( 23140273 )
2013
37
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
38
The future of tic disorder treatment. ( 24175754 )
2013
39
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. ( 23487208 )
2013
40
Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey. ( 23516770 )
2013
41
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
42
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
43
A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia. ( 21915912 )
2012
44
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
45
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
46
Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomania. ( 21440858 )
2011
47
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. ( 20378921 )
2011
48
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 A9 2 factorial design study. ( 21331638 )
2011
49
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. ( 21431421 )
2011
50
The clinical syndrome of primary tic disorder associated with dystonia: a large clinical series and a review of the literature. ( 21506147 )
2011

Variations for Tic Disorder

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 DRD2 DRD4 DRD5 SLC18A2 SLC6A3
2
Show member pathways
11.87 DRD2 DRD4 DRD5
3 11.85 HSPD1 HTR2A TPH2
4
Show member pathways
11.65 DRD2 SLC18A2 SLC6A3
5 11.6 HTR2A SLC18A2 TPH2
6
Show member pathways
11.51 DRD2 DRD4 SLC18A2
7
Show member pathways
10.98 DRD2 DRD4 DRD5 HTR2A
8 10.97 SLC18A2 SLC6A3
9
Show member pathways
10.97 SLC6A3 TDO2 TPH2
10 10.78 DRD2 DRD5
11 10.58 HTR2A SLC18A2 TPH2

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
2 non-motile cilium GO:0097730 8.62 DRD2 DRD5

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.7 DRD4 DRD5 HTR2A
2 locomotory behavior GO:0007626 9.69 DRD2 SLC18A2 SLC6A3
3 positive regulation of multicellular organism growth GO:0040018 9.65 DRD2 SLC6A3
4 negative regulation of adenylate cyclase activity GO:0007194 9.65 DRD2 DRD4
5 negative regulation of blood pressure GO:0045776 9.64 DRD2 DRD5
6 adult behavior GO:0030534 9.64 DRD2 SLITRK1
7 associative learning GO:0008306 9.63 DRD2 DRD5
8 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD4
9 regulation of dopamine secretion GO:0014059 9.62 DRD2 HTR2A
10 temperature homeostasis GO:0001659 9.62 DRD2 HTR2A
11 response to iron ion GO:0010039 9.61 DRD2 SLC6A3
12 synaptic transmission, dopaminergic GO:0001963 9.61 DRD2 DRD5
13 negative regulation of protein secretion GO:0050709 9.6 DRD2 DRD4
14 positive regulation of kinase activity GO:0033674 9.59 DRD4 HTR2A
15 behavioral response to ethanol GO:0048149 9.58 DRD2 DRD4
16 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.58 DRD2 HTR2A
17 dopamine metabolic process GO:0042417 9.57 DRD2 DRD4
18 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.56 DRD2 DRD5
19 negative regulation of voltage-gated calcium channel activity GO:1901386 9.55 DRD2 DRD4
20 prepulse inhibition GO:0060134 9.54 DRD2 SLC6A3
21 response to cocaine GO:0042220 9.54 DRD2 DRD5 SLC6A3
22 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.49 DRD2 DRD4
23 regulation of dopamine metabolic process GO:0042053 9.48 DRD4 SLC6A3
24 adenohypophysis development GO:0021984 9.46 DRD2 SLC6A3
25 monoamine transport GO:0015844 9.43 SLC18A2 SLC6A3
26 dopamine transport GO:0015872 9.4 SLC18A2 SLC6A3
27 behavioral response to cocaine GO:0048148 9.33 DRD2 DRD4 HTR2A
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.32 DRD2 DRD4
29 response to histamine GO:0034776 9.26 DRD2 DRD4
30 dopamine receptor signaling pathway GO:0007212 9.13 DRD2 DRD4 DRD5
31 response to amphetamine GO:0001975 8.92 DRD2 DRD4 DRD5 SLC18A2

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 DRD2 DRD4 DRD5 HTR2A
2 drug binding GO:0008144 9.46 DRD2 DRD4 HTR2A SLC6A3
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD2 DRD4
4 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC6A3
5 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD4 DRD5
6 dopamine binding GO:0035240 8.92 DRD2 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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