MCID: TCD001
MIFTS: 49

Tic Disorder malady

Mental diseases, Fetal diseases categories
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Summaries for Tic Disorder

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Disease Ontology:8 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary: Tic Disorder is related to chronic tic disorder and oppositional defiant disorder. An important gene associated with Tic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are GPCRs, Other and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drug clonazepam and the compounds (-)-sulpiride and (+)-sulpiride have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and skin, and related mouse phenotype behavior/neurological.

Wikipedia:65 Tic disorders are defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Aliases & Classifications for Tic Disorder

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Related Diseases for Tic Disorder

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Diseases related to Tic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1chronic tic disorder31.1OFCC1, DRD4, DNAJC13, AKAP17A
2oppositional defiant disorder30.7DRD4
3gilles de la tourette syndrome30.6HTR2A, DRD4, DRD2
4attention deficit hyperactivity disorder30.6TPH2, HTR2A, DRD4, DRD2
5anxiety disorder30.6TPH2
6conduct disorder30.3DRD4, DRD2
7obsessive-compulsive disorder30.3TPH2, HTR2A, DRD4, DRD2
8migraine29.8HTR2A, DRD4, DRD2
9schizophrenia29.7TPH2, HTR2A, DRD4, DRD2
10transient tic disorder10.5
11neuroleptic malignant syndrome10.3DRD2
12pathological gambling10.2DRD2, DRD4
13delusional disorder10.2DRD2, DRD4
14heroin dependence10.2DRD4, DRD2
15substance dependence10.2DRD2, DRD4
16trichotillomania10.2
17neuronitis10.2
18autism spectrum disorder10.2
19chorea10.2
20blindness10.2
21substance abuse10.1DRD4, DRD2
22hyperprolactinemia10.1DRD4, DRD2
23nicotine dependence10.1DRD2, DRD4
24seasonal affective disorder10.0DRD4, HTR2A
25motor neuron disease10.0
26autoimmune thyroiditis10.0
27fragile x syndrome10.0
28rheumatic fever10.0
29restless legs syndrome10.0
30common cold10.0
31arteriovenous malformation10.0
32dystonia10.0
33migraine with aura10.0
34thyroiditis10.0
35acanthocytosis10.0
36childhood-onset schizophrenia10.0
37pandas10.0
38sydenham's chorea10.0
39mental retardation10.0
40ataxia10.0
41tremor10.0
42personality disorder10.0DRD2, DRD4, TPH2
43bipolar disorder10.0DRD2, HTR2A
44antisocial personality disorder10.0DRD2, HTR2A
45schizoaffective disorder9.9DRD2, DRD4, HTR2A
46panic disorder9.9TPH2, HTR2A, DRD4
47alcohol dependence9.9DRD2, DRD4, HTR2A
48narcolepsy9.8DRD2, HTR2A
49anorexia nervosa9.8HTR2A, DRD4
50parkinson's disease9.7DRD2, DRD4, HTR2A

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to tic disorder

Symptoms for Tic Disorder

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Drugs & Therapeutics for Tic Disorder

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Drug clinical trials:

Search ClinicalTrials for Tic Disorder

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Tic Disorder

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Anatomical Context for Tic Disorder

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MalaCards organs/tissues related to Tic Disorder:

32
Brain, Thyroid, Skin, B cells

Animal Models for Tic Disorder or affiliated genes

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MGI Mouse Phenotypes related to Tic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4DRD2, DRD4, HTR2A, TPH2, HSPD1

Publications for Tic Disorder

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Articles related to Tic Disorder:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. (25020072)
2014
2
Reward enhances tic suppression in children within months of tic disorder onset. (25220075)
2014
3
Post-operative Adult Onset Tic Disorder: A Rare Presentation. (25336779)
2014
4
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). (24633901)
2014
5
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
6
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. (24343476)
2013
7
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. (23821420)
2013
8
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. (21431421)
2011
9
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. (21241949)
2011
10
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. (20378921)
2011
11
Anxiety symptoms in boys with autism spectrum disorder, attention-deficit hyperactivity disorder, or chronic multiple tic disorder and community controls. (20143146)
2010
12
Tic Disorder: An Unusual Presentation of Neurotoxoplasmosis in a Patient with AIDS. (21113285)
2010
13
Clinical research into Qufeng Zhidong Recipe used to treat 31 children with tic disorder. (21053620)
2010
14
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. (19864199)
2009
15
Aripiprazole treatment in an adolescent patient with chronic motor tic disorder and treatment-resistant obsessive-compulsive disorder. (19706223)
2009
16
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. (19698938)
2009
17
Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. (20035592)
2009
18
The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. (19913659)
2009
19
Open label aripiprazole in the treatment of youth with tic disorders. (19702496)
2009
20
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. (18439116)
2008
21
Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorder. (17896073)
2008
22
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. (17717739)
2008
23
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
24
Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity. (17537072)
2007
25
Plasma kynurenine and related measures in tic disorder patients. (17665285)
2007
26
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. (17171537)
2007
27
An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disorders. (17685747)
2007
28
Candidate locus for chorea and tic disorders at 15q? (17628228)
2007
29
Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats. (17013915)
2006
30
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. (17052389)
2006
31
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. (16536367)
2006
32
A case of adult onset tic disorder following carbon monoxide intoxication. (15198457)
2004
33
Transient tic disorder following carbon monoxide poisoning. (15356451)
2004
34
Association of small life events with self reports of tic severity in pediatric and adult tic disorder patients: a prospective longitudinal study. (15096084)
2004
35
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. (11694329)
2001
36
History of tic disorders and Gilles de la Tourette syndrome: part 5 of the MDS-sponsored history of movement disorders exhibit, Barcelona, June 2000. (11295792)
2001
37
Quetiapine for tic disorder: a case report. (11853307)
2001
38
Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. (10853926)
2000
39
Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. (10823299)
2000
40
Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder. (11063087)
2000
41
A functional-analytic approach to the diagnosis of a transient tic disorder. (8959431)
1996
42
Psychotic symptoms and a diagnosis of schizophrenia follow an initial diagnosis of tic disorder. (8973056)
1996
43
Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. (7771914)
1995
44
Tic disorder associated with encephalopathy in advanced HIV disease. (7926707)
1994
45
Nortriptyline treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8428873)
1993
46
Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. (8444765)
1993
47
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. (8227493)
1993
48
A case of post-traumatic tic disorder. (2682216)
1989
49
Auditory hallucinosis and atypical tic disorder: case reports. (4030705)
1985
50
Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome. (3974894)
1985

Variations for Tic Disorder

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Expression for genes affiliated with Tic Disorder

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Expression patterns in normal tissues for genes affiliated with Tic Disorder

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Pathways for genes affiliated with Tic Disorder

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Compounds for genes affiliated with Tic Disorder

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Compounds related to Tic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1(-)-sulpiride289.9DRD2, DRD4
2(+)-sulpiride289.9DRD2, DRD4
3clotiapine449.9HTR2A, DRD2
4eticlopride44 2810.9DRD2, DRD4
5(11c)-n-methylspiperone449.9DRD2, HTR2A
6l-741,62661 2810.8HTR2A, DRD2
7nemonapride44 50 2811.8DRD4, DRD2
8amperozide449.8HTR2A, DRD2
9eedq449.8DRD2, HTR2A
10molindone28 1110.7HTR2A, DRD2
11amisulpride44 28 1111.7HTR2A, DRD2
12sch 23390449.7DRD4, DRD2
13aniracetam44 28 1111.6DRD2, HTR2A
14zuclopenthixol44 50 1111.6DRD2, HTR2A
15piribedil28 4410.6DRD2, DRD4
16melperone449.6DRD2, DRD4, HTR2A
17(+)-butaclamol44 2810.6HTR2A, DRD4, DRD2
18remoxipride44 1110.6DRD4, HTR2A, DRD2
19loxapine28 44 1111.6DRD4, DRD2, HTR2A
20raclopride44 2810.6DRD2, DRD4, HTR2A
21roxindole28 4410.6DRD4, HTR2A, DRD2
22fluphenazine28 44 50 1112.6DRD4, HTR2A, DRD2
23terguride44 2810.6DRD2, DRD4, HTR2A
24piperazine44 1110.6HTR2A, DRD4, DRD2
25spiperone44 2810.6DRD4, DRD2, HTR2A
26promazine44 1110.6HTR2A, DRD4, DRD2
27ropinirole44 1110.6HTR2A, DRD4, DRD2
28lisuride44 28 1111.6HTR2A, DRD2, DRD4
29pergolide44 28 1111.6HTR2A, DRD2, DRD4
30paliperidone44 1110.6DRD2, DRD4, HTR2A
31iloperidone50 44 28 1112.6DRD4, DRD2, HTR2A
32pramipexole44 28 50 1112.6DRD4, HTR2A, DRD2
33quinpirole44 2810.5DRD4, HTR2A, DRD2
34asenapine28 1110.5HTR2A, DRD4, DRD2
35cabergoline44 28 1111.5HTR2A, DRD4, DRD2
36aripiprazole28 44 50 24 1113.5HTR2A, DRD2, DRD4
37ziprasidone28 50 44 1112.5DRD4, HTR2A, DRD2
38apomorphine28 44 1111.5DRD2, DRD4, HTR2A
39quetiapine44 50 28 24 1113.5DRD4, HTR2A, DRD2
40bromocriptine44 28 1111.5DRD2, DRD4, HTR2A
41chlorpromazine28 44 50 1112.5HTR2A, DRD4, DRD2
42risperidone44 50 28 61 24 1114.5HTR2A, DRD4, DRD2
43fluoxetine44 50 28 1112.5HTR2A, DRD2, TPH2
44olanzapine44 50 28 24 1113.4DRD4, DRD2, HTR2A
45thiothixene28 1110.4DRD2, HTR2A
46clozapine44 28 50 1112.3DRD2, DRD4, HTR2A
47maoa449.2HTR2A, DRD2, DRD4, TPH2
48fluspirilene28 44 1111.2HTR2A, DRD2
495-hydroxytryptamine449.2TPH2, DRD4, HTR2A, DRD2
50haloperidol44 50 28 2 1113.2DRD2, DRD4, HTR2A

GO Terms for genes affiliated with Tic Disorder

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Cellular components related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.6DRD2, DRD4

Biological processes related to Tic Disorder according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:0347769.9DRD2, DRD4
2positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.9DRD4, DRD2
3negative regulation of voltage-gated calcium channel activityGO:19013869.9DRD4, DRD2
4adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.9DRD4, DRD2
5behavioral response to ethanolGO:0481499.9DRD2, DRD4
6dopamine metabolic processGO:0424179.8DRD4, DRD2
7negative regulation of protein secretionGO:0507099.8DRD4, DRD2
8synaptic transmission, dopaminergicGO:0019639.8DRD4, DRD2
9arachidonic acid secretionGO:0504829.8DRD2, DRD4
10negative regulation of synaptic transmission, glutamatergicGO:0519679.8HTR2A, DRD2
11negative regulation of adenylate cyclase activityGO:0071949.7DRD2, DRD4
12temperature homeostasisGO:0016599.6DRD2, HTR2A
13release of sequestered calcium ion into cytosolGO:0512099.6HTR2A, DRD2
14response to amphetamineGO:0019759.5DRD2, DRD4
15positive regulation of ERK1 and ERK2 cascadeGO:0703749.5DRD2, HTR2A
16behavioral response to cocaineGO:0481489.5DRD2, DRD4, HTR2A
17circadian rhythmGO:0076239.5DRD4, TPH2
18cellular calcium ion homeostasisGO:0068749.5DRD2, DRD4, HTR2A
19B cell activationGO:0421139.4AKAP17A, HSPD1

Molecular functions related to Tic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.6DRD2, DRD4
2potassium channel regulator activityGO:0154599.6DRD2, DRD4
3dopamine bindingGO:0352409.3DRD2, DRD4
4drug bindingGO:0081449.1DRD2, DRD4, HTR2A

Products for genes affiliated with Tic Disorder

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Sources for Tic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet