MCID: TCK001
MIFTS: 55

Tick-Borne Encephalitis malady

Neuronal diseases, Infectious diseases, Immune diseases categories

Summaries for Tick-Borne Encephalitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in tick-borne encephalitis virus, which is transmitted by ixodes ticks. the infection has symptom drowsiness, has symptom confusion, has symptom sensory disturbances, and has symptom paralysis.

MalaCards: Tick-Borne Encephalitis, also known as siberian tick-borne encephalitis, is related to encephalitis and west nile encephalitis, and has symptoms including sensory disturbances, drowsiness and confusion. An important gene associated with Tick-Borne Encephalitis is OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa), and among its related pathways are Immune System and Hepatitis C. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Wikipedia:63 Tick-borne encephalitis (TBE) is a viral infectious disease involving the central nervous system. The... more...

Aliases & Classifications for Tick-Borne Encephalitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
tick-borne encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

tick-borne encephalitis 8 42 10 48 60
siberian tick-borne encephalitis 8 60
dermacentor-borne necrosis - erythema - lymphadenopathy 48
western european tick-borne encephalitis 8
encephalitis, russian spring-summer 60
russian spring-summer encephalitis 8
encephalitis, central european 60
central european encephalitis 8
west-siberian encephalitis 8
encephalitis tick-borne 44
taiga encephalitis 8
far eastern tbe 8


External Ids:

Disease Ontology8 DOID:0050175
ICD9CM27 063.2
MeSH34 D004675
MESH via Orphanet35 D004675
SNOMED-CT via Orphanet57 414093008, 415821008
ICD10 via Orphanet26 A84.0, A84.1, A84.8 A84.9, more
UMLS via Orphanet61 C0014061

Related Diseases for Tick-Borne Encephalitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tick-Borne Encephalitis:



Diseases related to tick-borne encephalitis

Clinical Features for Tick-Borne Encephalitis

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8Disease Ontology
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Symptoms:

8
  • sensory disturbances
  • drowsiness
  • confusion
  • paralysis

Drugs & Therapeutics for Tick-Borne Encephalitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tick-Borne Encephalitis

Drug clinical trials:

Search ClinicalTrials for Tick-Borne Encephalitis

Search NIH Clinical Center for Tick-Borne Encephalitis

Search CenterWatch for Tick-Borne Encephalitis

Genetic Tests for Tick-Borne Encephalitis

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Anatomical Context for Tick-Borne Encephalitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Tick-Borne Encephalitis:

32
Brain, Testes, T cells, B cells, Spleen, Kidney, Spinal cord, Liver

FMA organs/tissues related to Tick-Borne Encephalitis:

14
Brain

Animal Models for Tick-Borne Encephalitis or affiliated genes

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Publications for Tick-Borne Encephalitis

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50PubMed
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Articles related to Tick-Borne Encephalitis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Recombinant chimeric Japanese encephalitis virus/tick-borne encephalitis virus is attenuated and protective in mice. (24394443)
2014
2
Tick-borne encephalitis: a disease neglected by travel medicine. (23916617)
2013
3
Tick-borne encephalitis virus and louping-ill virus may co-circulate in Southern Norway. (23808981)
2013
4
Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system. (23805778)
2013
5
Surveillance of tick-borne encephalitis virus in wild birds and ticks in Tomsk city and its suburbs (Western Siberia). (24380691)
2013
6
Diagnostic potential and antigenic properties of recombinant tick-borne encephalitis virus subviral particles expressed in mammalian cells from Semliki Forest virus replicon. (24371235)
2013
7
ssICAM-1, IL-21 and IL-23 in patients with tick borne encephalitis and neuroborreliosis. (22705151)
2012
8
Isolated meningomyeloradiculitis following infection with tick borne encephalitis virus. (22425461)
2012
9
Prevalence of tick borne encephalitis virus in tick nymphs in relation to climatic factors on the southern coast of Norway. (22913287)
2012
10
Tick-borne encephalitis virus-neutralizing antibodies in different immunoglobulin preparations. (22379062)
2012
11
Neutrophil apoptosis induction by tick-borne encephalitis virus. (22808506)
2012
12
Tick-borne encephalitis in children. (22688618)
2012
13
Tick-borne encephalitis is associated with low levels of interleukin-10 in cerebrospinal fluid. (22957110)
2011
14
First complete genomic characterization of two tick-borne encephalitis virus isolates obtained from wild rodents in South Korea. (21286797)
2011
15
Evaluation of serological tests for detecting tick-borne encephalitis virus (TBEV) antibodies in animals. (22191165)
2011
16
Acute myositis associated with the initial phase of tick-borne encephalitis. (21684201)
2011
17
Tick-borne encephalitis virus, Kyrgyzstan. (21529400)
2011
18
Tick-borne encephalitis after vaccination: vaccine failure or misdiagnosis. (20854899)
2010
19
Variability of the tick-borne encephalitis virus genome in the 5' noncoding region derived from ticks Ixodes persulcatus and Ixodes pavlovskyi in Western Siberia. (19877811)
2010
20
Can goats be used as sentinels for tick-borne encephalitis (TBE) in nonendemic areas? Experimental studies and epizootiological observations. (21141272)
2010
21
Booster vaccinations against tick-borne encephalitis: 6 years follow-up indicates long-term protection. (19786143)
2009
22
Vertical transmission of tick-borne encephalitis virus between generations of adapted reservoir small rodents. (19111585)
2009
23
Spatial and temporal organization of tick-borne encephalitis flavivirus replicated RNA in living cells. (18667221)
2008
24
Socio-economic factors in the differential upsurge of tick-borne encephalitis in Central and Eastern Europe. (18183571)
2008
25
Quality control assessment for the serological diagnosis of tick borne encephalitis virus infections. (17267281)
2007
26
Tick-borne encephalitis: from epidemiology to vaccination recommendations in 2007. New issues--best practices. (17564770)
2007
27
Detection strategies of tick-borne encephalitis virus in Swedish Ixodes ricinus reveal evolutionary characteristics of emerging tick-borne flaviviruses. (17277902)
2007
28
Climate change cannot explain the upsurge of tick-borne encephalitis in the Baltics. (17551580)
2007
29
Unusual case of tick borne encephalitis with isolated myeloradiculitis. (17237139)
2007
30
Elevated concentration of the chemokine CCL3 (MIP-1alpha) in cerebrospinal fluid and serum of patients with tick borne encephalitis. (17357337)
2006
31
Tick-borne encephalitis in eastern France. (16798704)
2006
32
Role of the N-linked glycans of the prM and E envelope proteins in tick-borne encephalitis virus particle secretion. (15811651)
2005
33
Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation. (15530690)
2004
34
Tick-borne encephalitis in southern Norway. (15109431)
2004
35
Sub-genomic replicons of Tick-borne encephalitis virus. (15168210)
2004
36
Cytogenetic disorders in peripheral blood lymphocytes of patients with febrile form of tick-borne encephalitis. (15085248)
2004
37
An attempt to elucidate the increased incidence of tick-borne encephalitis and its spread to higher altitudes in the Czech Republic. (15146985)
2004
38
Role of heparan sulfate for attachment and entry of tick-borne encephalitis virus. (12706093)
2003
39
Tolerability of modified tick-borne encephalitis vaccine FSME-IMMUN "NEW" in children: results of post-marketing surveillance. (12531353)
2003
40
Tick-borne encephalitis. (12628808)
2003
41
Tick-borne encephalitis virus within and outside Japan: a cause for concern? (12082310)
2002
42
Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence. (11884577)
2002
43
Structural and functional characteristics of lymphocytes in chronic carriers of tick-borne encephalitis virus. (12802455)
2002
44
An uncommon severe clinical course of European tick-borne encephalitis. (12572899)
2002
45
Potential significance of transovarial transmission in the circulation of tick-borne encephalitis virus. (12641208)
2002
46
Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia. (11098535)
2000
47
Tick-borne viral encephalitis--the threat of summer. (10782389)
2000
48
Clinical distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (10762112)
2000
49
The serological response and long-lasting resistance against infection with louping-ill virus in sheep immunized with a highly attenuated tick-borne encephalitis virus. (4982559)
1969
50
Studies of viruses of the tick-borne encephalitis complex. II. Disease and immune responses in man following accidental infection with Kyasanur Forest disease virus. (14476341)
1962

Genetic Variations for Tick-Borne Encephalitis

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Expression for genes affiliated with Tick-Borne Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tick-Borne Encephalitis

Search GEO for disease gene expression data for Tick-Borne Encephalitis.

Pathways for genes affiliated with Tick-Borne Encephalitis

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53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2OAS1, OAS2, OAS3, OASL
210.2IFIT1, OAS3, OAS2, OAS1
3
Hide members
10.1IFIT1, IVNS1ABP, OAS3, OAS2, OAS1
4
Hide members
10.0IFIT2, IFIT1, OASL, OAS3, OAS2
5
Immune response IFN alpha/beta signaling pathway
Hide members
10.0OAS1, OAS2, OAS3, OASL, IFIT1, IFIT2

Compounds for genes affiliated with Tick-Borne Encephalitis

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44Novoseek
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Compounds related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4410.1IL21, CXCL11, ICAM3, ICAM2
22,5-oligoadenylate449.9OAS1, OAS2, OAS3, OASL

GO Terms for genes affiliated with Tick-Borne Encephalitis

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16Gene Ontology
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Biological processes related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of ribonuclease activityGO:06070010.5OAS1, OAS3
2cellular response to interferon-alphaGO:03545710.5IFIT2, OAS1
3positive regulation of tissue remodelingGO:03410510.5IL23A, IL21
4purine nucleotide biosynthetic processGO:00616410.4OAS2, OAS1
5interferon-gamma-mediated signaling pathwayGO:06033310.4OAS1, OAS2, OAS3, OASL
6negative regulation of viral genome replicationGO:04507110.4IFIT1, OASL, OAS3, OAS1
7positive regulation of interleukin-17 productionGO:03274010.3IL23A, IL21
8positive regulation of interleukin-10 productionGO:03273310.3IL23A, IL21
9cell-cell adhesionGO:01633710.3ICAM2, ICAM3, SCRIB, CBLL1
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3IL23A, IL21
11type I interferon-mediated signaling pathwayGO:06033710.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
12cytokine-mediated signaling pathwayGO:01922110.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
13RNA catabolic processGO:00640110.2RNASEH2A, OAS2
14response to virusGO:00961510.2OAS1, IFIT2, IFIT1, IVNS1ABP, OASL, OAS3
15defense response to virusGO:05160710.1IFIT2, IFIT1, IL23A, OASL, OAS3, OAS2
16negative regulation of protein bindingGO:03209110.0IFIT1, IFIT2

Molecular functions related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00372510.2OAS1, OAS2, OAS3, OASL
22-5-oligoadenylate synthetase activityGO:00173010.0OAS2, OAS3

Products for genes affiliated with Tick-Borne Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tick-Borne Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet