MCID: TCK001
MIFTS: 55

Tick-Borne Encephalitis malady

Neuronal diseases, Infectious diseases, Immune diseases categories

Summaries for Tick-Borne Encephalitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in tick-borne encephalitis virus, which is transmitted by ixodes ticks. the infection has symptom drowsiness, has symptom confusion, has symptom sensory disturbances, and has symptom paralysis.

MalaCards: Tick-Borne Encephalitis, also known as siberian tick-borne encephalitis, is related to encephalitis and west nile encephalitis, and has symptoms including paralysis, sensory disturbances and confusion. An important gene associated with Tick-Borne Encephalitis is OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa), and among its related pathways are Immune System and Hepatitis C. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Wikipedia:63 Tick-borne encephalitis (TBE) is a viral infectious disease involving the central nervous system. The... more...

Aliases & Classifications for Tick-Borne Encephalitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
tick-borne encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

tick-borne encephalitis 8 42 10 48 60
siberian tick-borne encephalitis 8 60
dermacentor-borne necrosis - erythema - lymphadenopathy 48
western european tick-borne encephalitis 8
encephalitis, russian spring-summer 60
russian spring-summer encephalitis 8
encephalitis, central european 60
central european encephalitis 8
west-siberian encephalitis 8
encephalitis tick-borne 44
taiga encephalitis 8
far eastern tbe 8


External Ids:

Disease Ontology8 DOID:0050175
ICD9CM27 063.2
MeSH34 D004675
MESH via Orphanet35 D004675
SNOMED-CT via Orphanet57 414093008, 415821008
ICD10 via Orphanet26 A84.0, A84.1, A84.8 A84.9, more
UMLS via Orphanet61 C0014061

Related Diseases for Tick-Borne Encephalitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tick-Borne Encephalitis:



Diseases related to tick-borne encephalitis

Clinical Features for Tick-Borne Encephalitis

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8Disease Ontology
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Symptoms:

8
  • paralysis
  • sensory disturbances
  • confusion
  • drowsiness

Drugs & Therapeutics for Tick-Borne Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tick-Borne Encephalitis

Drug clinical trials:

Search ClinicalTrials for Tick-Borne Encephalitis

Search NIH Clinical Center for Tick-Borne Encephalitis

Search CenterWatch for Tick-Borne Encephalitis

Genetic Tests for Tick-Borne Encephalitis

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Anatomical Context for Tick-Borne Encephalitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Tick-Borne Encephalitis:

32
Brain, Testes, T cells, Liver, Kidney, Spinal cord, B cells, Spleen

FMA organs/tissues related to Tick-Borne Encephalitis:

14
Brain

Animal Models for Tick-Borne Encephalitis or affiliated genes

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Publications for Tick-Borne Encephalitis

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Sources:
50PubMed
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Articles related to Tick-Borne Encephalitis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Tick-borne encephalitis (TBE): an underestimated riska8 (22765977)
still: repor
2
Clusterons as a tool for monitoring populations of tick-borne encephalitis virus. (24037877)
2014
3
Factors associated with seroimmunity against tick borne encephalitis virus 10 years after booster vaccination. (23306371)
2013
4
Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus. (24329534)
2013
5
Response to "Limitations of the study 'Cost-effectiveness of tick-borne encephalitis vaccination in Slovenian adults"'. (23523403)
2013
6
Tick-borne encephalitis virus triggers inositol-requiring enzyme 1 (IRE1) and transcription factor 6 (ATF6) pathways of unfolded protein response. (24177270)
2013
7
New endemic foci of tick-borne encephalitis (TBE) identified in districts where testing for TBE was not available before 2009 in Poland. (23777675)
2013
8
Babesia canis and tick-borne encephalitis virus (TBEV) co-infection in a sled dog. (24069843)
2013
9
Isolated polio-like syndrome after tick-borne encephalitis presenting with acute hyperckemia. (22057312)
2012
10
Rate of evolution and molecular epidemiology of tick-borne encephalitis virus in Europe, including two isolations from the same focus 44 years apart. (22205716)
2012
11
Epidemiology of tick-borne encephalitis in the Czech Republic 1970-2008. (23025693)
2012
12
Tick-borne encephalitis in children and adolescents in the Czech Republic between 1960 and 2007. (23151866)
2012
13
Tick-borne encephalitis in Latvia 1973-2009: epidemiology, clinical features and sequelae. (21615626)
2012
14
Phylogenetic and virulence analysis of tick-borne encephalitis virus field isolates from Switzerland. (21412794)
2011
15
Tick-borne encephalitis in childhood: rare or missed? (21412206)
2011
16
Tick-borne encephalitis virus in dogs--is this an issue? (21489255)
2011
17
Tick-borne encephalitis virus in wild rodents in winter, Finland, 2008-2009. (21192857)
2011
18
Tick-borne encephalitis in the age of general mobility. (20300927)
2010
19
Tick-borne encephalitis presenting as fever without localising signs--a case series. (19888601)
2010
20
Tick-borne encephalitis: from childhood to golden age does increased mobility mean increased risk? Conference report of the 11th meeting of the International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE). (19945411)
2010
21
Vaccine failures after active immunisation against tick-borne encephalitis. (20167301)
2010
22
Safety evaluation of chimeric Langat/Dengue 4 flavivirus, a live vaccine candidate against tick-borne encephalitis. (19697399)
2009
23
Prevalence and genetic variability of tick-borne encephalitis virus in host-seeking Ixodes ricinus in northern Italy. (19675189)
2009
24
Analysis of the envelope (E) protein gene of tick-borne encephalitis viruses isolated in South Korea. (19480604)
2009
25
Tick-borne encephalitis in Styrian children from 1981 to 2005: a retrospective study and a review of the literature. (18394095)
2008
26
Tick-borne encephalitis: rounding out the picture. (18445450)
2008
27
Humoral immune response to structural and nonstructural proteins of tick-borne encephalitis virus in the natural history of the disease]. (18756813)
2008
28
Isolation of tick-borne encephalitis viruses from wild rodents, South Korea. (18240970)
2008
29
Advances in vaccination against tick-borne encephalitis. (18564014)
2008
30
Tick-borne encephalitis in Swiss children 2000-2004: five-year nationwide surveillance of epidemiologic characteristics and clinical course. (18434938)
2008
31
Tick-borne encephalitis in Europe and beyond--the epidemiological situation as of 2007. (18761916)
2008
32
Construction and application of chimeric virus-like particles of tick-borne encephalitis virus and mosquito-borne Japanese encephalitis virus. (18089744)
2008
33
Changes in the metabolic activity of macrophages under the influence of tick-borne encephalitis virus. (17367298)
2007
34
Seroprevalence study of Tick-borne encephalitis, Borrelia burgdorferi, Dengue and Toscana virus in Turin Province. (16312014)
2007
35
Heterogeneity of 3'-Untraslated Region of Genome RNA of the Tick-Borne Encephalitis Virus (TBEV) Strains Isolated from Ticks in the Western Siberia, Russia. (23675045)
2007
36
A simple spatial model to explain the distribution of human tick-borne encephalitis cases in hungary. (17187571)
2006
37
Development of an enzyme-linked immunosorbent assay for serological diagnosis of tick-borne encephalitis using subviral particles. (16540179)
2006
38
Combined prime-boost vaccination against tick-borne encephalitis (TBE) using a recombinant vaccinia virus and a bacterial plasmid both expressing TBE virus non-structural NS1 protein. (16076390)
2005
39
The importance of tick-borne encephalitis virus RNA detection for early differential diagnosis of tick-borne encephalitis. (15919235)
2005
40
TBE booster immunization in adults--first experience with a new tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer. (15146995)
2004
41
A tick-borne encephalitis ceiling in Central Europe has moved upwards during the last 30 years: possible impact of global warming? (15146984)
2004
42
State-of-the-art serological techniques for detection of antibodies against tick-borne encephalitis virus. (15146997)
2004
43
Isolation of capsid protein dimers from the tick-borne encephalitis flavivirus and in vitro assembly of capsid-like particles. (15254179)
2004
44
Serological screening of Tick-borne encephalitis (TBE) among Malaysian encephalitis patients. (16493408)
2004
45
Two severe cases of tick-borne encephalitis despite complete active vaccination--the significance of neutralizing antibodies. (15015020)
2004
46
Characterization of tick-borne encephalitis virus from Estonia. (15484275)
2004
47
Tick-borne encephalitis--pathogenesis, clinical course and long-term follow-up. (12628810)
2003
48
Randomized, phase II dose-finding studies of a modified tick-borne encephalitis vaccine: evaluation of safety and immunogenicity. (14615149)
2003
49
Safety, immunogenicity and tolerability of a new pediatric tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer. (12922086)
2003
50
Tick-borne encephalitis virus in Lithuania. (11837641)
2001

Genetic Variations for Tick-Borne Encephalitis

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Expression for genes affiliated with Tick-Borne Encephalitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tick-Borne Encephalitis

Search GEO for disease gene expression data for Tick-Borne Encephalitis.

Pathways for genes affiliated with Tick-Borne Encephalitis

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53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2OAS1, OAS2, OAS3, OASL
210.2IFIT1, OAS3, OAS2, OAS1
3
Hide members
10.1IFIT1, IVNS1ABP, OAS3, OAS2, OAS1
4
Hide members
10.0IFIT2, IFIT1, OASL, OAS3, OAS2
5
Immune response IFN alpha/beta signaling pathway
Hide members
10.0OAS1, OAS2, OAS3, OASL, IFIT1, IFIT2

Compounds for genes affiliated with Tick-Borne Encephalitis

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44Novoseek
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Compounds related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4410.1IL21, CXCL11, ICAM3, ICAM2
22,5-oligoadenylate449.9OAS1, OAS2, OAS3, OASL

GO Terms for genes affiliated with Tick-Borne Encephalitis

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16Gene Ontology
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Biological processes related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of ribonuclease activityGO:06070010.5OAS1, OAS3
2cellular response to interferon-alphaGO:03545710.5IFIT2, OAS1
3positive regulation of tissue remodelingGO:03410510.5IL23A, IL21
4purine nucleotide biosynthetic processGO:00616410.4OAS2, OAS1
5interferon-gamma-mediated signaling pathwayGO:06033310.4OAS1, OAS2, OAS3, OASL
6negative regulation of viral genome replicationGO:04507110.4IFIT1, OASL, OAS3, OAS1
7positive regulation of interleukin-17 productionGO:03274010.3IL23A, IL21
8positive regulation of interleukin-10 productionGO:03273310.3IL23A, IL21
9cell-cell adhesionGO:01633710.3ICAM2, ICAM3, SCRIB, CBLL1
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3IL23A, IL21
11type I interferon-mediated signaling pathwayGO:06033710.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
12cytokine-mediated signaling pathwayGO:01922110.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
13RNA catabolic processGO:00640110.2RNASEH2A, OAS2
14response to virusGO:00961510.2OAS1, IFIT2, IFIT1, IVNS1ABP, OASL, OAS3
15defense response to virusGO:05160710.1IFIT2, IFIT1, IL23A, OASL, OAS3, OAS2
16negative regulation of protein bindingGO:03209110.0IFIT1, IFIT2

Molecular functions related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00372510.2OAS1, OAS2, OAS3, OASL
22-5-oligoadenylate synthetase activityGO:00173010.0OAS2, OAS3

Products for genes affiliated with Tick-Borne Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tick-Borne Encephalitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet