MCID: TCK001
MIFTS: 50

Tick-Borne Encephalitis malady

Neuronal, Infectious, Immune categories

Summaries for Tick-Borne Encephalitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in tick-borne encephalitis virus, which is transmitted by ixodes ticks. the infection has symptom drowsiness, has symptom confusion, has symptom sensory disturbances, and has symptom paralysis.

MalaCards: Tick-Borne Encephalitis, also known as siberian tick-borne encephalitis, is related to west nile encephalitis and japanese encephalitis, and has symptoms including paralysis, confusion and drowsiness. An important gene associated with Tick-Borne Encephalitis is OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa), and among its related pathways are Immune System and Hepatitis C. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and spinal cord.

Wikipedia:64 Tick-borne encephalitis (TBE) is a viral infectious disease involving the central nervous system. The... more...

Aliases & Classifications for Tick-Borne Encephalitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal, Immune


Characteristics (Orphanet epidemiological data):

49
tick-borne encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

tick-borne encephalitis 8 43 10 49 61
siberian tick-borne encephalitis 8 61
dermacentor-borne necrosis - erythema - lymphadenopathy 49
western european tick-borne encephalitis 8
encephalitis, russian spring-summer 61
russian spring-summer encephalitis 8
encephalitis, central european 61
central european encephalitis 8
west-siberian encephalitis 8
encephalitis tick-borne 45
taiga encephalitis 8
far eastern tbe 8


External Ids:

Disease Ontology8 DOID:0050175
ICD9CM27 063.2
MeSH35 D004675
MESH via Orphanet36 D004675
ICD10 via Orphanet26 A84
SNOMED-CT via Orphanet58 414093008, 415821008
UMLS via Orphanet62 C0014061

Related Diseases for Tick-Borne Encephalitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tick-Borne Encephalitis:



Diseases related to tick-borne encephalitis

Clinical Features for Tick-Borne Encephalitis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • paralysis
  • confusion
  • drowsiness
  • sensory disturbances

Drugs & Therapeutics for Tick-Borne Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tick-Borne Encephalitis

Drug clinical trials:

Search ClinicalTrials for Tick-Borne Encephalitis

Search NIH Clinical Center for Tick-Borne Encephalitis

Search CenterWatch for Tick-Borne Encephalitis

Genetic Tests for Tick-Borne Encephalitis

Anatomical Context for Tick-Borne Encephalitis

Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Tick-Borne Encephalitis:

33
Liver, Spinal cord, Brain, Kidney, Spleen, T cells, B cells

FMA organs/tissues related to Tick-Borne Encephalitis:

14
Brain

Animal Models for Tick-Borne Encephalitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Tick-Borne Encephalitis

Sources:
51PubMed
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Articles related to Tick-Borne Encephalitis:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
The variable region of the 3' untranslated region is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in a mouse model. (24394696)
2014
2
Detection and genetic characterization of tick-borne encephalitis virus (TBEV) derived from ticks removed from red foxes (Vulpes vulpes) and isolated from spleen samples of red deer (Cervus elaphus) in Croatia. (24035586)
2014
3
Tick-borne encephalitis virus in ticks detached from humans and follow-up of serological and clinical response. (24275477)
2014
4
Evaluation of Different Serological Diagnostic Methods for Tick-Borne Encephalitis Virus: Enzyme-Linked Immunosorbent, Immunofluorescence, and Neutralization Assay. (24359414)
2013
5
Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus. (23266832)
2013
6
Tick-borne encephalitis virus (TBEV) infection in horses: clinical and laboratory findings and epidemiological investigations. (23395291)
2013
7
Limitations of the study "Cost-effectiveness of tick-borne encephalitis vaccination in Slovenian adults". (23352724)
2013
8
May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis? (23822550)
2013
9
Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication. (22796133)
2012
10
Tick-borne encephalitis in Slovenia: data from a questionnaire survey. (22448719)
2012
11
SiRNA inhibits replication of Langat virus, a member of the tick-borne encephalitis virus complex in organotypic rat brain slices. (22984545)
2012
12
Patterns of tick-borne encephalitis virus infection in rodents in Slovenia. (22022821)
2012
13
Tick-borne encephalitis--still a serious disease? (22695812)
2012
14
Forecasting risk of tick-borne encephalitis (TBE): using data from wildlife and climate to predict next year's number of human victims. (21254953)
2011
15
Chimeric tick-borne encephalitis/dengue virus is attenuated in Ixodes scapularis ticks and Aedes aegypti mosquitoes. (21142950)
2011
16
Breakdown of the blood-brain barrier during tick-borne encephalitis in mice is not dependent on CD8+ T-cells. (21629771)
2011
17
The current perspective on tick-borne encephalitis awareness and prevention in six Central and Eastern European countries: report from a meeting of experts convened to discuss TBE in their region. (21549781)
2011
18
Inactivation of the tick-borne encephalitis virus by RNA-cleaving compounds. (22872801)
2011
19
Complete genome sequence analysis of tick-borne encephalitis viruses isolated in northeastern China. (21614436)
2011
20
Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus. (21785855)
2011
21
Isolated reversible splenial lesion in tick-borne encephalitis: a case report and literature review. (21371818)
2011
22
Isolation and molecular characterization of a tick-borne encephalitis virus strain from a new tick-borne encephalitis focus with severe cases in Bavaria, Germany. (21771510)
2010
23
Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA. (19409841)
2009
24
Structural modeling of the NS 3 helicase of Tick-borne encephalitis virus and their virtual screening of potent drugs using molecular docking. (20640834)
2009
25
Immune thrombocytopenic purpura reactivation after tick-borne encephalitis vaccination. (19596412)
2009
26
Prevalence of tick-borne encephalitis virus in Ixodes ricinus from a novel endemic area of North Eastern Italy. (19107965)
2009
27
Upsurge of tick-borne encephalitis in the Baltic States at the time of political transition, independent of changes in public health practices. (19154483)
2009
28
Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers. (18207289)
2008
29
The prevalence of tick-borne encephalitis in the region of West Bohemia (Czech Republic) between 1960-2005. (18330525)
2008
30
Peripheral neuromotor status in convalescents after tick-borne encephalitis. (19145314)
2008
31
Tick-borne encephalitis virus, ticks and humans: short-term and long-term dynamics. (18725794)
2008
32
A survey on cases of tick-borne encephalitis in European countries. (18445446)
2008
33
Multiple transmissions of tick-borne encephalitis virus between Japan and Russia. (17660689)
2007
34
Field effectiveness of vaccination against tick-borne encephalitis. (17869389)
2007
35
Antibody persistence following booster vaccination against tick-borne encephalitis: 3-year post-booster follow-up. (17555850)
2007
36
Natural tick-borne encephalitis virus infection among wild small mammals in the southeastern part of western Siberia, Russia. (16584325)
2006
37
Intranasal immunization with inactivated tick-borne encephalitis virus and the antigenic peptide 89-119 protects mice against intraperitoneal challenge. (16545605)
2006
38
Differences in maturation of tick-borne encephalitis virus in mammalian and tick cell line. (16491019)
2006
39
Tick-borne encephalitis (TBE) in SkAYne, southern Sweden: A new TBE endemic region? (16938735)
2006
40
Heterologous gene expression by infectious and replicon vectors derived from tick-borne encephalitis virus and direct comparison of this flavivirus system with an alphavirus replicon. (15784898)
2005
41
The basic reproductive number of tick-borne encephalitis virus. An empirical approach. (15940535)
2005
42
Protection against tick-borne encephalitis with a new vaccine formulation free of protein-derived stabilizers. (15996453)
2005
43
Experimental transmission of Karshi and Langat (tick-borne encephalitis virus complex) viruses by Ornithodoros ticks (Acari: Argasidae). (15535630)
2004
44
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
45
Phagocytic functions of the blood in patients with acute tick-borne encephalitis. (12717518)
2003
46
Spontaneous mutations restore the viability of tick-borne encephalitis virus mutants with large deletions in protein C. (12477849)
2003
47
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
48
Tick-borne encephalitis (TBE) in dogs. (12141763)
2002
49
An abortive form of tick-borne encephalitis (TBE)--a rare clinical manifestation of infection with TBE virus. (12422615)
2002
50
Tick-borne encephalitis (TBE) in Germany and clinical course of the disease. (12141760)
2002

Genetic Variations for Tick-Borne Encephalitis

Expression for genes affiliated with Tick-Borne Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tick-Borne Encephalitis

Search GEO for disease gene expression data for Tick-Borne Encephalitis.

Pathways for genes affiliated with Tick-Borne Encephalitis

Sources:
54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2OASL, OAS3, OAS2, OAS1
210.2IFIT1, OAS3, OAS2, OAS1
3
Hide members
10.1OAS1, OAS2, OAS3, IVNS1ABP, IFIT1
4
Hide members
10.0OAS2, OAS3, OASL, IFIT1, IFIT2
5
Immune response IFN alpha/beta signaling pathway
Hide members
10.0IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1

Compounds for genes affiliated with Tick-Borne Encephalitis

Sources:
45Novoseek
See all sources

Compounds related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4510.1IL21, CXCL11, ICAM3, ICAM2
22,5-oligoadenylate459.9OAS1, OAS2, OAS3, OASL

GO Terms for genes affiliated with Tick-Borne Encephalitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of ribonuclease activityGO:06070010.5OAS1, OAS3
2cellular response to interferon-alphaGO:03545710.5IFIT2, OAS1
3positive regulation of tissue remodelingGO:03410510.5IL23A, IL21
4purine nucleotide biosynthetic processGO:00616410.4OAS2, OAS1
5interferon-gamma-mediated signaling pathwayGO:06033310.4OAS1, OAS2, OAS3, OASL
6negative regulation of viral genome replicationGO:04507110.4IFIT1, OASL, OAS3, OAS1
7positive regulation of interleukin-17 productionGO:03274010.3IL23A, IL21
8positive regulation of interleukin-10 productionGO:03273310.3IL23A, IL21
9cell-cell adhesionGO:01633710.3ICAM2, ICAM3, SCRIB, CBLL1
10positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.3IL23A, IL21
11type I interferon-mediated signaling pathwayGO:06033710.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
12cytokine-mediated signaling pathwayGO:01922110.2IFIT2, IFIT1, OASL, OAS3, OAS2, OAS1
13RNA catabolic processGO:00640110.2RNASEH2A, OAS2
14response to virusGO:00961510.2OAS1, IFIT2, IFIT1, IVNS1ABP, OASL, OAS3
15defense response to virusGO:05160710.1IFIT2, IFIT1, IL23A, OASL, OAS3, OAS2
16negative regulation of protein bindingGO:03209110.0IFIT1, IFIT2

Molecular functions related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:00372510.2OAS1, OAS2, OAS3, OASL
22-5-oligoadenylate synthetase activityGO:00173010.0OAS2, OAS3

Products for genes affiliated with Tick-Borne Encephalitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tick-Borne Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet