MCID: TCK001
MIFTS: 53

Tick-Borne Encephalitis malady

Rare diseases, Neuronal diseases, Infectious diseases, Skin diseases, Immune diseases categories
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Summaries for Tick-Borne Encephalitis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in brain, has material basis in tick-borne encephalitis virus, which is transmitted by ixodes ticks. the infection has symptom drowsiness, has symptom confusion, has symptom sensory disturbances, and has symptom paralysis.

MalaCards: Tick-Borne Encephalitis, also known as siberian tick-borne encephalitis, is related to multiple sclerosis and encephalitis, and has symptoms including paralysis, sensory disturbances and confusion. An important gene associated with Tick-Borne Encephalitis is OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa), and among its related pathways are NOD-like Receptor Signaling Pathways and Interferon Signaling. The compounds rantes and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and testes.

Wikipedia:65 Tick-borne encephalitis (TBE) is a viral infectious disease involving the central nervous system. The... more...

Aliases & Classifications for Tick-Borne Encephalitis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 45Novoseek, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
tick-borne encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

tick-borne encephalitis 8 43 10 49 62
siberian tick-borne encephalitis 8 62
dermacentor-borne necrosis - erythema - lymphadenopathy 49
western european tick-borne encephalitis 8
encephalitis, russian spring-summer 62
russian spring-summer encephalitis 8
encephalitis, central european 62
central european encephalitis 8
west-siberian encephalitis 8
encephalitis tick-borne 45
taiga encephalitis 8
far eastern tbe 8


External Ids:

Disease Ontology8 DOID:0050175
MeSH35 D004675
ICD9CM27 063.2
MESH via Orphanet36 D004675
SNOMED-CT via Orphanet59 414093008, 415821008
ICD10 via Orphanet26 A84.0, A84.1, A84.8 A84.9, more
UMLS via Orphanet63 C0014061

Related Diseases for Tick-Borne Encephalitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tick-Borne Encephalitis:



Diseases related to tick-borne encephalitis

Symptoms for Tick-Borne Encephalitis

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8Disease Ontology
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Symptoms:

8
  • paralysis
  • sensory disturbances
  • confusion
  • drowsiness

Drugs & Therapeutics for Tick-Borne Encephalitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Tick-Borne Encephalitis

Search NIH Clinical Center for Tick-Borne Encephalitis

Genetic Tests for Tick-Borne Encephalitis

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Anatomical Context for Tick-Borne Encephalitis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Tick-Borne Encephalitis:

33
Brain, Testes, T cells, Liver, Kidney, Spinal cord, B cells, Spleen

FMA organs/tissues related to Tick-Borne Encephalitis:

14
Brain

Animal Models for Tick-Borne Encephalitis or affiliated genes

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Publications for Tick-Borne Encephalitis

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Sources:
52PubMed
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Articles related to Tick-Borne Encephalitis:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Tick-borne encephalitis virus, Zealand, Denmark, 2011. (23764123)
2013
2
Tick-borne encephalitis virus vaccine as additional alternative neoantigen for the clinical immunologist's toolbox. (23273959)
2013
3
Tick-borne encephalitis: a disease neglected by travel medicine. (23916617)
2013
4
Tick-borne encephalitis associated with consumption of raw goat milk, Slovenia, 2012. (23697658)
2013
5
Factors associated with seroimmunity against tick borne encephalitis virus 10 years after booster vaccination. (23306371)
2013
6
Low coverage and predictors of vaccination uptake against tick-borne encephalitis in Slovenia. (21398380)
2012
7
ssICAM-1, IL-21 and IL-23 in patients with tick borne encephalitis and neuroborreliosis. (22705151)
2012
8
Peripheral facial palsy in patients with tick-borne encephalitis. (22192120)
2012
9
Age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis. (22461903)
2012
10
Isolated meningomyeloradiculitis following infection with tick borne encephalitis virus. (22425461)
2012
11
Prevalence of tick borne encephalitis virus in tick nymphs in relation to climatic factors on the southern coast of Norway. (22913287)
2012
12
Prevalence and molecular characterization of tick-borne encephalitis virus in Ixodes ricinus ticks collected in Slovenia. (21028962)
2011
13
Tick-borne encephalitis in Poland in years 1993-2008--epidemiology and clinical presentation. A retrospective study of 687 patients. (21143706)
2011
14
Needle-free jet injection of DNA and protein vaccine of the far-eastern subtype of tick-borne encephalitis virus induces protective immunity in mice. (22004565)
2011
15
Transcriptional upregulation of SOCS 1 and suppressors of cytokine signaling 3 mRNA in the absence of suppressors of cytokine signaling 2 mRNA after infection with West Nile virus or tick-borne encephalitis virus. (20854017)
2010
16
What tick-borne encephalitis may look like: clinical signs and symptoms. (20970727)
2010
17
Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA. (19409841)
2009
18
Safety evaluation of chimeric Langat/Dengue 4 flavivirus, a live vaccine candidate against tick-borne encephalitis. (19697399)
2009
19
First identification of tick-borne encephalitis in Denmark outside of Bornholm, August 2009. (19758543)
2009
20
Alimentary transmission of tick-borne encephalitis in the Czech Republic (1997-2008). (19526924)
2009
21
Spatial and temporal organization of tick-borne encephalitis flavivirus replicated RNA in living cells. (18667221)
2008
22
Tick-borne encephalitis in Styrian children from 1981 to 2005: a retrospective study and a review of the literature. (18394095)
2008
23
A newly detected tick-borne encephalitis (TBE) focus in south-east Sweden: a follow-up study of TBE virus (TBEV) seroprevalence. (17852896)
2008
24
Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers. (18207289)
2008
25
Variable spikes in tick-borne encephalitis incidence in 2006 independent of variable tick abundance but related to weather. (19068106)
2008
26
The prevalence of tick-borne encephalitis in the region of West Bohemia (Czech Republic) between 1960-2005. (18330525)
2008
27
Tick-borne encephalitis incidence in Central and Eastern Europe: consequences of political transition. (18316221)
2008
28
Changes in the metabolic activity of macrophages under the influence of tick-borne encephalitis virus. (17367298)
2007
29
Setting an alert for tick-borne encephalitis. (18026017)
2007
30
Elevated concentration of the chemokine CCL3 (MIP-1alpha) in cerebrospinal fluid and serum of patients with tick borne encephalitis. (17357337)
2006
31
A simple spatial model to explain the distribution of human tick-borne encephalitis cases in hungary. (17187571)
2006
32
Severe tick-borne encephalitis in Slovenia in the years 2001-2005: time for a mass vaccination campaign? (17186173)
2006
33
Natural tick-borne encephalitis virus infection among wild small mammals in the southeastern part of western Siberia, Russia. (16584325)
2006
34
Prevalence and incidence of antibodies to Borrelia burgdorferi and to tick-borne encephalitis virus in agricultural and forestry workers from Tuscany, Italy. (15948001)
2005
35
Combined prime-boost vaccination against tick-borne encephalitis (TBE) using a recombinant vaccinia virus and a bacterial plasmid both expressing TBE virus non-structural NS1 protein. (16076390)
2005
36
Humoral and cellular immune response to RNA immunization with flavivirus replicons derived from tick-borne encephalitis virus. (16306582)
2005
37
Attempt to detect evidence for tick-borne encephalitis virus in ticks and mammalian wildlife in The Netherlands. (15815150)
2005
38
A synthetic peptide based on the NS1 non-structural protein of tick-borne encephalitis virus induces a protective immune response against fatal encephalitis in an experimental animal model. (16022903)
2005
39
Tick-borne encephalitis virus infections in Lithuanian domestic animals and ticks. (16191893)
2005
40
Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus]. (15143669)
2004
41
Characterization of a membrane-associated trimeric low-pH-induced Form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization. (14990739)
2004
42
Antibodies to DNA in the blood of patients with tick-borne encephalitis]. (15456145)
2004
43
Long-term immunity after vaccination against tick-borne encephalitis with Encepur using the rapid vaccination schedule. (15146994)
2004
44
Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice. (14687719)
2003
45
Fluorescent probing of lymphocyte and erythrocyte plasma membranes in persistence of tick-borne encephalitis virus: monitoring of structural changes. (14631506)
2003
46
Characterisation of human tick-borne encephalitis virus from Sweden. (14556277)
2003
47
Shift of the tick Ixodes ricinus and tick-borne encephalitis to higher altitudes in central Europe. (12736793)
2003
48
Epidemiological, clinical and laboratory distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. (12422617)
2002
49
Tick-borne encephalitis (TBE) in dogs. (12141763)
2002
50
Tick-borne encephalitis virus NS1 glycoprotein during acute and persistent infection of cells. (11410315)
2001

Variations for Tick-Borne Encephalitis

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Expression for genes affiliated with Tick-Borne Encephalitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tick-Borne Encephalitis

Search GEO for disease gene expression data for Tick-Borne Encephalitis.

Pathways for genes affiliated with Tick-Borne Encephalitis

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50PathCards, 54R&D Systems, 60Thomson Reuters, 55Reactome, 30KEGG
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Compounds for genes affiliated with Tick-Borne Encephalitis

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45Novoseek
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Compounds related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes459.1CD209, TLR3
22,5-oligoadenylate458.0OAS3, OAS1, OAS2, TLR3

GO Terms for genes affiliated with Tick-Borne Encephalitis

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16Gene Ontology
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Cellular components related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160208.7CD209, OAS2, TLR3
2cytoplasmGO:0057377.4CD209, OAS3, OAS1, OAS2, TLR3

Biological processes related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of ribonuclease activityGO:0607009.7OAS3, OAS1
2purine nucleotide biosynthetic processGO:0061649.7OAS1, OAS2
3negative regulation of viral genome replicationGO:0450719.4OAS1, OAS3
4type I interferon signaling pathwayGO:0603379.3OAS2, OAS1, OAS3
5interferon-gamma-mediated signaling pathwayGO:0603339.2OAS2, OAS1, OAS3
6response to virusGO:0096159.2OAS2, OAS1, OAS3
7nucleobase-containing compound metabolic processGO:0061399.2OAS2, OAS3
8cytokine-mediated signaling pathwayGO:0192219.1OAS3, OAS1, OAS2
9positive regulation of apoptotic processGO:0430659.0SCRIB, TLR3
10defense response to virusGO:0516078.5OAS3, OAS1, OAS2, TLR3

Molecular functions related to Tick-Borne Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
12-5-oligoadenylate synthetase activityGO:0017309.1OAS3, OAS1, OAS2
2ATP bindingGO:0055249.1OAS3, OAS1, OAS2
3metal ion bindingGO:0468728.3OAS2, OAS1, OAS3, CD209
4double-stranded RNA bindingGO:0037258.2OAS3, OAS1, OAS2, TLR3

Products for genes affiliated with Tick-Borne Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tick-Borne Encephalitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet