MCID: TCK003
MIFTS: 27

Tick-Borne Relapsing Fever malady

Infectious diseases category

Aliases & Classifications for Tick-Borne Relapsing Fever

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Aliases & Descriptions for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 10 12 65
Tick-Borne Relapsing Fever Nos 10
 
Relapsing Fever, Tick-Borne 10


Classifications:



External Ids:

Disease Ontology10 DOID:13036
ICD9CM29 087.1
SNOMED-CT59 186821005, 10301003
NCIt42 C34976
ICD1027 A68.1

Summaries for Tick-Borne Relapsing Fever

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Disease Ontology:10 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has material basis in borrelia hermsii, has material basis in borrelia parkeri or has material basis in borrelia duttoni, which are transmitted by soft ticks (ornithodoros parkeri and ornithodoros hermsii). the infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary: Tick-Borne Relapsing Fever, also known as tick-borne relapsing fever nos, is related to relapsing fever and malaria, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Tick-Borne Relapsing Fever is CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit), and among its related pathways are Complement and coagulation cascades and Pertussis.

Related Diseases for Tick-Borne Relapsing Fever

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Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing fever11.3
2malaria10.4
3glanders10.4
4radiculopathy10.4
5myocarditis10.4
6tick infestation10.4
7acute respiratory distress syndrome10.4
8headache10.4
9complex regional pain syndrome9.9C3, SERPING1
10acquired fructose intolerance9.8C3, SERPING1
11renal adenoma9.7AKAP13, CLPX
12balanoposthitis9.0AKAP13, C3, CLPX, MAP6, PURA, SERPING1

Graphical network of diseases related to Tick-Borne Relapsing Fever:



Diseases related to tick-borne relapsing fever

Symptoms for Tick-Borne Relapsing Fever

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Symptoms:

 10
  • tachypnea
  • tachycardia
  • hepatosplenomegaly
  • lymphadenopathy

Drugs & Therapeutics for Tick-Borne Relapsing Fever

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Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxycyclineapproved, investigationalPhase 2, Phase 3204564-25-054671203, 5281011
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Adoxa
Alodox
Alti-Doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Doryx
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy 100
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline
Doxycycline (200mg/day) or Placebo
Doxycycline (INN)
 
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline hydrochloride
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
Morgidox
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Ocudox
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Monohydrate
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
2
Ampicillinapproved5069-53-46249
Synonyms:
(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1h8s
33604-21-6
37234-64-3
47355-94-2
50584-05-9
6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid
6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
6-(a-Aminophenylacetamido)penicillanic acid
6-D(-)-alpha-Aminophenylacetamido-penicillanic acid
6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI
69-52-3 (mono-hydrochloride salt)
69-53-4
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
7177-48-2 (TRIHYDRATE)
800-79-3
8056-87-9
96707-69-6
98520-55-9
A9393_SIGMA
AB-PC
AB-PC Sol
ABPC
AC-14075
AC1L1M46
AMP
AMPI
AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2)
AP
AY 6108
AY 6108
AY-6108
Acillin
Adobacillin
Alpen
Amblosin
Amcill
Amfipen
Amfipen V
Amfipen v
Aminobenzylpenicillin
Amipenix S
Ampen
Ampi-Co
Ampi-Tab
Ampi-bol
Ampi-co
Ampi-tab
Ampichel
Ampicil
Ampicilina
Ampicilina [INN-Spanish]
Ampicillin
Ampicillin (USP/INN)
Ampicillin A
Ampicillin Acid
Ampicillin Anhydrate
Ampicillin Anhydrous
Ampicillin Base
Ampicillin Sodium
Ampicillin Trihydrate
Ampicillin [USAN:BAN:INN:JAN]
Ampicillin [USAN:INN:BAN:JAN]
Ampicillin [Usan:Ban:Inn:Jan]
Ampicillin acid
Ampicillin anhydrate
Ampicillin sodium
Ampicillina
Ampicillina [DCIT]
Ampicillina [Dcit]
Ampicilline
Ampicilline [INN-French]
Ampicillinum
Ampicillinum [INN-Latin]
Ampicin
Ampifarm
Ampikel
Ampimed
Ampipenin
Ampipenin, nt3
Ampiscel
Ampisyn
Ampivax
Ampivet
Amplacilina
Amplin
Amplipenyl
Amplisom
Amplital
Ampy-Penyl
Anhydrous Ampicillin
Anhydrous ampicillin
Anhydrous ampicillin (JP15)
Austrapen
BA 7305
BIDD:GT0184
BPBio1_000142
BRL 1341
BRL-1341
BSPBio_000128
BSPBio_001862
Bayer 5427
Binotal
Bonapicillin
Britacil
C06574
CHEBI:28971
CHEBI:53713
CHEMBL174
CID6249
Campicillin
Cimex
Copharcilin
D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid
D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid
D-(-)-Ampicillin
D-(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
D-(-)-ampicillin
D-(−)-6-(α-aminophenylacetamido)penicillanic acid
D-(−)-ampicillin
D-Ampicillin
D-Cillin
D-a-Aminobenzylpenicillin
D00204
DB00415
Delcillin
Deripen
 
DivK1c_000466
Divercillin
Doktacillin
Duphacillin
EINECS 200-709-7
Geocillin
Grampenil
Guicitrina
Guicitrine
HI 63
HMS2090I11
HSDB 3009
IDI1_000466
KBio1_000466
KBio2_000430
KBio2_002998
KBio2_005566
KBio3_001362
KBioGR_000598
KBioSS_000430
KS-R1
LS-1586
LS-169948
Lifeampil
MLS000028405
MLS001074168
Magnapen
Marcillin
MolPort-001-794-635
Morepen
NCGC00023282-05
NCGC00023282-06
NINDS_000466
NSC 528986
NSC-528986
NSC528986
Norobrittin
Novo-ampicillin
Nuvapen
OMNIPEN (AMPICILLIN)
Olin Kid
Olin kid
Omnipen
Omnipen (TN)
Omnipen-N
Orbicilina
P 50
P-50
Pen A
Pen A Oral
Pen Ampil
Pen a
Pen ampil
Penbristol
Penbritin
Penbritin paediatric
Penbritin syrup
Penbritin-S
Penbrock
Penicillin, Aminobenzyl
Penicline
Penimic
Pensyn
Pentrex
Pentrexl
Pentrexyl
Pentritin
Pfizerpen A
Pfizerpen a
Pfizerpen-A
Polycillin
Polycillin-N
Polyflex (Veterinary)
Ponecil
Prestwick0_000114
Prestwick1_000114
Prestwick2_000114
Prestwick3_000114
Princillin
Principen
Principen '125'
Principen '250'
Principen '500'
QIDamp
Qidamp
Racenacillin
Ro-Ampen
Ro-ampen
Rosampline
Roscillin
SBB063111
SK-Ampicillin
SK-ampicillin
SMP1_000211
SMR000058352
SPBio_000818
SPBio_002067
SQ 17382
Semicillin
Semicillin R
Servicillin
Spectrum2_000769
Spectrum3_000301
Spectrum4_000149
Spectrum5_000814
Spectrum_000050
Sumipanto
Supen
Synpenin
Texcillin
Tokiocillin
Tolomol
Totacillin
Totacillin (sodium)
Totacillin-N
Totalciclina
Totapen
Trifacilina
UNII-7C782967RD
Ukapen
Ultrabion
Ultrabron
Vampen
Viccillin
Viccillin S
Vidocillin
Vidopen
WY-5103
Wypicil
alpha-Aminobenzylpenicillin
ampicillanyl
ampicillin
anhydrous ampicillin
3Emetics159

Interventional clinical trials:

idNameStatusNCT IDPhase
1Post Exposure Treatment With Doxycycline for the Prevention of Relapsing FeverCompletedNCT00237016Phase 2, Phase 3
2Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareRecruitingNCT01431326
3Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)Active, not recruitingNCT01766830

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

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Anatomical Context for Tick-Borne Relapsing Fever

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Animal Models for Tick-Borne Relapsing Fever or affiliated genes

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Publications for Tick-Borne Relapsing Fever

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Articles related to Tick-Borne Relapsing Fever:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. (25892254)
2015
2
Tick-borne Relapsing Fever in Children in the North-west of Iran, Qazvin. (26445390)
2015
3
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. (25251880)
2014
4
Tick-borne relapsing fever in pregnancy. (23939208)
2013
5
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. (24107216)
2013
6
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. (21288847)
2011
7
Post exposure prophylaxis of tick-borne relapsing fever. (20012878)
2010
8
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
9
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. (19624916)
2009
10
Tick-borne relapsing fever: conjunctival haemorrhages. (21686925)
2009
11
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. (18454593)
2008
12
Tick-borne relapsing fever. (18755384)
2008
13
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. (19099321)
2008
14
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. (16815378)
2006
15
Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. (16625051)
2006
16
Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. (16837678)
2006
17
Doxycycline for the prevention of tick-borne relapsing fever. (17035657)
2006
18
Information from your family doctor. Tick-borne relapsing fever: what you should know. (16342835)
2005
19
Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida. (16081922)
2005
20
Tick-borne relapsing fever. (16342834)
2005
21
Absence of focal neurological involvement in tick-borne relapsing fever in northern Tanzania. (15885049)
2005
22
Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. (15004063)
2004
23
Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. (12182387)
2002
24
Tick-borne relapsing fever in North America. (11982310)
2002
25
The epidemiology of tick-borne relapsing fever in the United States. (12224586)
2002
26
Short report: Diagnosis of tick-borne relapsing fever by the quantitative buffy coat fluorescence method. (10344644)
1999
27
Tick-borne relapsing fever in the northwestern United States and southwestern Canada. (9455520)
1998
28
Tick-borne relapsing fever in British Columbia, Canada: first isolation of Borrelia hermsii. (9817862)
1998
29
Physical mapping of the Borrelia miyamotoi HT31 chromosome in comparison with that of Borrelia turicatae, an etiological agent of tick-borne relapsing fever. (8877131)
1996
30
An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. (7778052)
1995
31
Late relapse of tick-borne relapsing fever following treatment with doxycycline. (8434483)
1993
32
Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody. (1572965)
1992
33
Mortality in high risk patients with tick-borne relapsing fever analysed by the Borrelia-index. (1800081)
1991
34
Tick-borne relapsing fever in intravenous drug abusers. (2926174)
1989
35
Tick borne relapsing fever in Tanzanian children. (6498926)
1984
36
Single dose minocycline and doxycycline treatment of tick-borne relapsing fever. A double-blind clinical trial in Rwanda. (6365001)
1983
37
Tick-borne relapsing fever in children. (7454488)
1980
38
Tick-borne relapsing fever in Colorado. Historical review and report of cases. (374757)
1979
39
Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park. (871120)
1977
40
Tick-borne relapsing fever in the Judean hills, including a case with massive haematuria. (5707919)
1968
41
Tick-borne relapsing fever in Kashmir: mice inoculation--a diagnostic method of choice. (4964791)
1967
42
A STUDY ON INDIAN TICK-BORNE RELAPSING FEVER. (14154432)
1964
43
CLINICAL PICTURE AND THERAPY OF TICK-BORNE RELAPSING FEVER; SUMMARY OF 49 CASES. (14243147)
1964
44
Tick-borne relapsing fever in Cyprus. (13010108)
1952
45
Tick-borne relapsing fever in Somaliland with special reference to the blood sedimentation rate. (14832869)
1951
46
Tick-borne relapsing fever on the Witwatersrand gold mines; its treatment with aureomycin. (15442582)
1950
47
Prevention of tick-borne relapsing fever. (15411885)
1950
48
Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. (18138841)
1949
49
On tick-borne relapsing fever]. (21000989)
1945
50
Tick-borne Relapsing Fever. (20786348)
1945

Variations for Tick-Borne Relapsing Fever

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Expression for genes affiliated with Tick-Borne Relapsing Fever

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Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for genes affiliated with Tick-Borne Relapsing Fever

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Pathways related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3C3, SERPING1
29.3C3, SERPING1

GO Terms for genes affiliated with Tick-Borne Relapsing Fever

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Cellular components related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.3C3, SERPING1

Biological processes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:00069589.4C3, SERPING1
2negative regulation of endopeptidase activityGO:00109519.3C3, SERPING1

Sources for Tick-Borne Relapsing Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet