MCID: TCK003
MIFTS: 27

Tick-Borne Relapsing Fever malady

Category: Infectious diseases

Aliases & Classifications for Tick-Borne Relapsing Fever

About this section

Aliases & Descriptions for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 11 13 68
Tick-Borne Relapsing Fever Nos 11
 
Relapsing Fever, Tick-Borne 11

Classifications:



External Ids:

Disease Ontology11 DOID:13036
ICD1030 A68.1
SNOMED-CT62 10301003, 186821005
ICD9CM32 087.1
NCIt45 C34976

Summaries for Tick-Borne Relapsing Fever

About this section
Disease Ontology:11 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has material basis in Borrelia hermsii, has material basis in Borrelia parkeri or has material basis in Borrelia duttoni, which are transmitted by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary: Tick-Borne Relapsing Fever, also known as tick-borne relapsing fever nos, is related to relapsing fever and tick infestation, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Tick-Borne Relapsing Fever is CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit). Related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Tick-Borne Relapsing Fever

About this section

Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing fever11.3
2tick infestation11.1
3malaria10.1
4glanders9.9
5plasmodium falciparum malaria9.9
6radiculopathy9.9
7myocarditis9.9
8acute respiratory distress syndrome9.9
9headache9.9
10mechanical lagophthalmos9.7AKAP13, CLPX, PURA
11persistent fetal circulation syndrome8.9AKAP13, CLPX, GEN1, MAP6, PLG, PURA

Graphical network of diseases related to Tick-Borne Relapsing Fever:



Diseases related to tick-borne relapsing fever

Symptoms & Phenotypes for Tick-Borne Relapsing Fever

About this section

Symptoms:

 11 (show all 4)
  • tachypnea
  • tachycardia
  • hepatosplenomegaly
  • lymphadenopathy

GenomeRNAi Phenotypes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.0GEN1, PURA

Drugs & Therapeutics for Tick-Borne Relapsing Fever

About this section

Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Doxycyclineapproved, investigational, vet_approvedPhase 2, Phase 3243564-25-054671203
Synonyms:
(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10597-92-9
17086-28-1 (mono-hydrate)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)
24390-14-5
41411-66-9 (6-epimer, mono-hydrochloride)
5-Hydroxy-alpha-6-deoxytetracycline
5-hydroxy-╬▒-6-deoxytetracycline
564-25-0
6-Deoxyoxytetracycline
6-Deoxytetracycline
6-alpha-Deoxy-5-oxytetracycline
6-alpha-deoxy-5-oxytetracycline
69935-17-7 (mono-hydrochloride, di-hydrate)
6alpha-Deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6╬▒-deoxy-5-oxytetracycline
7164-70-7
7264-10-0
94088-85-4 (calcium salt (1:2))
AB08 (*Fosfatex)
AC1NQXW7
AC1NS4CW
AC1NUYS8
AC1O8PYM
Alti-Doxycycline
Anhydrous doxycycline
Apo-Doxy
Atridox
Azudoxat
BCBcMAP01_000024
BIDD:GT0146
BMY-28689
BPBio1_000951
BSPBio_000863
BSPBio_001936
BU-3839T
C06973
CHEBI:50845
CHEMBL1433
CID5281011
CID5353597
CID5463943
CID6713981
CPD001550033
D07876
DB00254
DMSC (*Fosfatex)
DOXCYCLINE ANHYDROUS
DOXY
DOXYCYCLINE CALCIUM
DOXYCYCLINE MONOHYDRATE
Deoxymykoin
DivK1c_000345
Dossiciclina
Dossiciclina [DCIT]
Doxcycline anhydrous
Doxiciclina
Doxiciclina [INN-Spanish]
Doxiciclina [Italian]
Doxitard
Doxivetin
Doxy-Caps
Doxy-Puren
Doxy-Tabs
Doxycen
Doxychel
Doxychel (TN)
Doxycin
Doxycyclin
Doxycycline (200mg/day) or Placebo
 
Doxycycline (INN)
Doxycycline (TN)
Doxycycline (anhydrous)
Doxycycline (internal use)
Doxycycline Hyclate
Doxycycline Monohydrate
Doxycycline anhydrous
Doxycycline hyclate
Doxycycline-Chinoin
Doxycyclinum
Doxycyclinum [INN-Latin]
Doxysol
Doxytec
Doxytetracycline
EINECS 209-271-1
GS-3065 (*monohydrate)
HMS2090E06
HSDB 3071
Hydramycin
IDI1_000345
Investin
Jenacyclin
KBio1_000345
KBio2_001287
KBio2_003855
KBio2_006423
KBio3_001156
KBioGR_001133
KBioSS_001287
LS-187766
LS-93868
Liviatin
Lopac0_000405
MolPort-002-507-423
Monodox
Monodox (*monohydrate)
NCGC00161602-01
NCGC00161602-03
NCGC00161602-04
NCGC00167961-01
NCGC00179395-01
NINDS_000345
NSC633557
Novo-Doxylin
Nu-Doxycycline
Oracea
Prestwick0_000852
Prestwick1_000852
Prestwick2_000852
Prestwick3_000852
Ronaxan
SAM002589932
SMP1_000107
SPBio_000246
SPBio_002784
STOCK1N-34341
Spanor
Spectrum2_000143
Spectrum3_000408
Spectrum4_000527
Spectrum5_000947
Spectrum_000807
Supracyclin
UNII-334895S862
UPCMLD-DP021
UPCMLD-DP021:001
Vibra-tabs
Vibramycin
Vibramycin (*monohydrate)
Vibramycin Novum
Vibramycine
Vibravenos
Vivox (*Hyclate)
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
alpha-Doxycycline
doxycycline
2Antiprotozoal AgentsPhase 2, Phase 32051
3Anti-Bacterial AgentsPhase 2, Phase 311226
4Antiparasitic AgentsPhase 2, Phase 32199
5AntimalarialsPhase 2, Phase 31246
6Anti-Infective AgentsPhase 2, Phase 322062
7Immunoglobulins6394
8Antibodies6394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Post Exposure Treatment With Doxycycline for the Prevention of Relapsing FeverCompletedNCT00237016Phase 2, Phase 3
2Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)CompletedNCT01766830

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

About this section

Anatomical Context for Tick-Borne Relapsing Fever

About this section

Publications for Tick-Borne Relapsing Fever

About this section

Articles related to Tick-Borne Relapsing Fever:

(show top 50)    (show all 106)
idTitleAuthorsYear
1
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. (28077149)
2017
2
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. (27832805)
2016
3
Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. (27284141)
2016
4
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. (27650717)
2016
5
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. (27430539)
2016
6
Tick-Borne Relapsing Fever in Dogs. (27353196)
2016
7
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. (27430543)
2016
8
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. (27100337)
2016
9
Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. (27417836)
2016
10
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. (27442975)
2016
11
Case report: a retrospective serological analysis indicating human exposure to tick-borne relapsing Fever spirochetes in Texas. (25856342)
2015
12
Tick-borne Relapsing Fever in Children in the North-west of Iran, Qazvin. (26445390)
2015
13
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. (25892254)
2015
14
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. (25251880)
2014
15
Tick-borne relapsing fever in pregnancy. (23939208)
2013
16
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. (24107216)
2013
17
Tick-borne relapsing fever with cutaneous eschar and radiculopathy, Ethiopia. (22776391)
2012
18
Endemic foci of the tick-borne relapsing fever spirochete Borrelia crocidurae in Mali, West Africa, and the potential for human infection. (23209863)
2012
19
Tick-borne relapsing fever borreliosis, rural senegal. (21529402)
2011
20
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. (21288847)
2011
21
Elevated troponin and jarisch-herxheimer reaction in tick-borne relapsing Fever: a case report. (22567483)
2011
22
Post exposure prophylaxis of tick-borne relapsing fever. (20012878)
2010
23
Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. (21124792)
2010
24
Tick-borne relapsing fever: conjunctival haemorrhages. (21686925)
2009
25
Congenital tick-borne relapsing fever: report of a case with transplacental transmission in the Islamic Republic of Iran. (19731794)
2009
26
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. (19624916)
2009
27
Tick-borne relapsing fever in a new highland endemic focus of western Iran. (19695158)
2009
28
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
29
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. (19099321)
2008
30
Community knowledge, attitudes and practices related to tick-borne relapsing fever in dodoma rural district, central Tanzania. (19024337)
2008
31
Tick-borne relapsing fever. (18755384)
2008
32
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. (18454593)
2008
33
Does tick-borne relapsing fever have an animal reservoir in East Africa? (18021022)
2007
34
Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. (17484230)
2007
35
Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. (16837678)
2006
36
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. (16815378)
2006
37
Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. (16625051)
2006
38
Killed in action: microbiologists and clinicians as victims of their occupation. Part 4: Tick-borne Relapsing Fever, Malta Fever, Glanders, SARS. (16423683)
2006
39
Doxycycline for the prevention of tick-borne relapsing fever. (17035657)
2006
40
Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida. (16081922)
2005
41
Information from your family doctor. Tick-borne relapsing fever: what you should know. (16342835)
2005
42
Absence of focal neurological involvement in tick-borne relapsing fever in northern Tanzania. (15885049)
2005
43
Tick-borne relapsing fever during pregnancy: a case report. (16363764)
2005
44
Tick-borne relapsing fever. (16342834)
2005
45
Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. (15004063)
2004
46
Tick-borne relapsing fever caused by Borrelia hermsii, Montana. (14519254)
2003
47
Tick-borne relapsing fever under-reported. (14558501)
2003
48
Outbreak of tick-borne relapsing fever at the north rim of the Grand Canyon: evidence for effectiveness of preventive measures. (12135272)
2002
49
Tick-borne relapsing fever caused by Borrelia turicatae. (12237608)
2002
50
Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. (12182387)
2002

Variations for Tick-Borne Relapsing Fever

About this section

Expression for genes affiliated with Tick-Borne Relapsing Fever

About this section
Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for genes affiliated with Tick-Borne Relapsing Fever

About this section

GO Terms for genes affiliated with Tick-Borne Relapsing Fever

About this section

Sources for Tick-Borne Relapsing Fever

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet