MCID: TCK003
MIFTS: 27

Tick-Borne Relapsing Fever malady

Categories: Infectious diseases

Aliases & Classifications for Tick-Borne Relapsing Fever

Aliases & Descriptions for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 12 14 69
Tick-Borne Relapsing Fever Nos 12
Relapsing Fever, Tick-Borne 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13036
ICD10 33 A68.1
ICD9CM 35 087.1
NCIt 47 C34976
SNOMED-CT 64 10301003 186821005
UMLS 69 C0035022

Summaries for Tick-Borne Relapsing Fever

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Tick-Borne Relapsing Fever, also known as tick-borne relapsing fever nos, is related to relapsing fever and tick infestation, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Tick-Borne Relapsing Fever is CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Tick-Borne Relapsing Fever

Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 relapsing fever 11.3
2 tick infestation 11.1
3 malaria 10.1
4 glanders 9.9
5 plasmodium falciparum malaria 9.9
6 radiculopathy 9.9
7 myocarditis 9.9
8 acute respiratory distress syndrome 9.9
9 headache 9.9
10 mechanical lagophthalmos 9.7 AKAP13 CLPX PURA
11 persistent fetal circulation syndrome 8.9 AKAP13 CLPX GEN1 MAP6 PLG PURA

Graphical network of the top 20 diseases related to Tick-Borne Relapsing Fever:



Diseases related to Tick-Borne Relapsing Fever

Symptoms & Phenotypes for Tick-Borne Relapsing Fever

Symptoms:

12
  • tachypnea
  • tachycardia
  • hepatosplenomegaly
  • lymphadenopathy

GenomeRNAi Phenotypes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.44 GEN1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.44 PURA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.44 PURA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.44 PURA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.44 PURA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.44 PURA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.44 GEN1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.44 GEN1 PURA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.44 GEN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.44 GEN1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.44 PURA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.44 PURA

Drugs & Therapeutics for Tick-Borne Relapsing Fever

Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Antimalarials Phase 2, Phase 3
5 Antiparasitic Agents Phase 2, Phase 3
6 Antiprotozoal Agents Phase 2, Phase 3
7 Immunoglobulins
8 Antibodies

Interventional clinical trials:


id Name Status NCT ID Phase
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3
2 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

Anatomical Context for Tick-Borne Relapsing Fever

Publications for Tick-Borne Relapsing Fever

Articles related to Tick-Borne Relapsing Fever:

(show top 50) (show all 106)
id Title Authors Year
1
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
2
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. ( 27832805 )
2016
3
Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. ( 27284141 )
2016
4
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. ( 27650717 )
2016
5
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. ( 27430539 )
2016
6
Tick-Borne Relapsing Fever in Dogs. ( 27353196 )
2016
7
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. ( 27430543 )
2016
8
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. ( 27100337 )
2016
9
Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. ( 27417836 )
2016
10
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )
2016
11
Case report: a retrospective serological analysis indicating human exposure to tick-borne relapsing Fever spirochetes in Texas. ( 25856342 )
2015
12
Tick-borne Relapsing Fever in Children in the North-west of Iran, Qazvin. ( 26445390 )
2015
13
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. ( 25892254 )
2015
14
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. ( 25251880 )
2014
15
Tick-borne relapsing fever in pregnancy. ( 23939208 )
2013
16
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. ( 24107216 )
2013
17
Tick-borne relapsing fever with cutaneous eschar and radiculopathy, Ethiopia. ( 22776391 )
2012
18
Endemic foci of the tick-borne relapsing fever spirochete Borrelia crocidurae in Mali, West Africa, and the potential for human infection. ( 23209863 )
2012
19
Tick-borne relapsing fever borreliosis, rural senegal. ( 21529402 )
2011
20
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. ( 21288847 )
2011
21
Elevated troponin and jarisch-herxheimer reaction in tick-borne relapsing Fever: a case report. ( 22567483 )
2011
22
Post exposure prophylaxis of tick-borne relapsing fever. ( 20012878 )
2010
23
Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. ( 21124792 )
2010
24
Tick-borne relapsing fever: conjunctival haemorrhages. ( 21686925 )
2009
25
Congenital tick-borne relapsing fever: report of a case with transplacental transmission in the Islamic Republic of Iran. ( 19731794 )
2009
26
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. ( 19624916 )
2009
27
Tick-borne relapsing fever in a new highland endemic focus of western Iran. ( 19695158 )
2009
28
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. ( 19411042 )
2009
29
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. ( 19099321 )
2008
30
Community knowledge, attitudes and practices related to tick-borne relapsing fever in dodoma rural district, central Tanzania. ( 19024337 )
2008
31
Tick-borne relapsing fever. ( 18755384 )
2008
32
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. ( 18454593 )
2008
33
Does tick-borne relapsing fever have an animal reservoir in East Africa? ( 18021022 )
2007
34
Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. ( 17484230 )
2007
35
Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. ( 16837678 )
2006
36
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. ( 16815378 )
2006
37
Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. ( 16625051 )
2006
38
Killed in action: microbiologists and clinicians as victims of their occupation. Part 4: Tick-borne Relapsing Fever, Malta Fever, Glanders, SARS. ( 16423683 )
2006
39
Doxycycline for the prevention of tick-borne relapsing fever. ( 17035657 )
2006
40
Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida. ( 16081922 )
2005
41
Information from your family doctor. Tick-borne relapsing fever: what you should know. ( 16342835 )
2005
42
Absence of focal neurological involvement in tick-borne relapsing fever in northern Tanzania. ( 15885049 )
2005
43
Tick-borne relapsing fever during pregnancy: a case report. ( 16363764 )
2005
44
Tick-borne relapsing fever. ( 16342834 )
2005
45
Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. ( 15004063 )
2004
46
Tick-borne relapsing fever caused by Borrelia hermsii, Montana. ( 14519254 )
2003
47
Tick-borne relapsing fever under-reported. ( 14558501 )
2003
48
Outbreak of tick-borne relapsing fever at the north rim of the Grand Canyon: evidence for effectiveness of preventive measures. ( 12135272 )
2002
49
Tick-borne relapsing fever caused by Borrelia turicatae. ( 12237608 )
2002
50
Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. ( 12182387 )
2002

Variations for Tick-Borne Relapsing Fever

Expression for Tick-Borne Relapsing Fever

Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for Tick-Borne Relapsing Fever

GO Terms for Tick-Borne Relapsing Fever

Sources for Tick-Borne Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....