MCID: TCK003
MIFTS: 33

Tick-Borne Relapsing Fever malady

Infectious diseases category
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Summaries for Tick-Borne Relapsing Fever

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8Disease Ontology, 4CDC, 33MalaCards
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Disease Ontology:8 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has material basis in borrelia hermsii, has material basis in borrelia parkeri or has material basis in borrelia duttoni, which are transmitted by soft ticks (ornithodoros parkeri and ornithodoros hermsii). the infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards: Tick-Borne Relapsing Fever, also known as tick-borne relapsing fever nos, is related to relapsing fever and radiculopathy, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Tick-Borne Relapsing Fever is PURA (purine-rich element binding protein A).

CDC:4 Relapsing fever is bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea. It is caused by certain species of Borrelia spirochetes. There are two types of relapsing fever:

Aliases & Classifications for Tick-Borne Relapsing Fever

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

tick-borne relapsing fever 8 10 62
tick-borne relapsing fever nos 8
relapsing fever, tick-borne 8


External Ids:

Disease Ontology8 DOID:13036
NCIt40 C34976
SNOMED-CT58 10301003, 186821005
ICD9CM27 087.1
ICD1025 A68.1

Related Diseases for Tick-Borne Relapsing Fever

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17GeneCards, 18GeneDecks
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Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1relapsing fever11.3
2radiculopathy10.4
3glanders10.4
4malaria10.4
5myocarditis10.4
6tick infestation10.4
7headache10.4
8blindness10.4

Graphical network of diseases related to Tick-Borne Relapsing Fever:



Diseases related to tick-borne relapsing fever

Symptoms for Tick-Borne Relapsing Fever

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8Disease Ontology
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Symptoms:

8
  • tachypnea
  • tachycardia
  • hepatosplenomegaly
  • lymphadenopathy

Drugs & Therapeutics for Tick-Borne Relapsing Fever

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tick-Borne Relapsing Fever

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Genetic Tests for Tick-Borne Relapsing Fever

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Anatomical Context for Tick-Borne Relapsing Fever

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Animal Models for Tick-Borne Relapsing Fever or affiliated genes

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Publications for Tick-Borne Relapsing Fever

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52PubMed
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Articles related to Tick-Borne Relapsing Fever:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Tick-borne relapsing fever in pregnancy. (23939208)
2013
2
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. (24107216)
2013
3
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. (21288847)
2011
4
Post exposure prophylaxis of tick-borne relapsing fever. (20012878)
2010
5
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
6
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. (19624916)
2009
7
Tick-borne relapsing fever: conjunctival haemorrhages. (21686925)
2009
8
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. (18454593)
2008
9
Tick-borne relapsing fever. (18755384)
2008
10
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. (19099321)
2008
11
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. (16815378)
2006
12
Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. (16625051)
2006
13
Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. (16837678)
2006
14
Doxycycline for the prevention of tick-borne relapsing fever. (17035657)
2006
15
Information from your family doctor. Tick-borne relapsing fever: what you should know. (16342835)
2005
16
Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida. (16081922)
2005
17
Tick-borne relapsing fever. (16342834)
2005
18
Absence of focal neurological involvement in tick-borne relapsing fever in northern Tanzania. (15885049)
2005
19
Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. (15004063)
2004
20
Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tick-borne relapsing fever. (12182387)
2002
21
Tick-borne relapsing fever in North America. (11982310)
2002
22
The epidemiology of tick-borne relapsing fever in the United States. (12224586)
2002
23
Detection of Borrelia duttonii, a tick-borne relapsing fever agent in central Tanzania, within ticks by flagellin gene-based nested polymerase chain reaction. (12653131)
2001
24
Short report: Diagnosis of tick-borne relapsing fever by the quantitative buffy coat fluorescence method. (10344644)
1999
25
Tick-borne relapsing fever in the northwestern United States and southwestern Canada. (9455520)
1998
26
Tick-borne relapsing fever in British Columbia, Canada: first isolation of Borrelia hermsii. (9817862)
1998
27
Tick-borne relapsing fever and pregnancy outcome in rural Tanzania. (9351408)
1997
28
Physical mapping of the Borrelia miyamotoi HT31 chromosome in comparison with that of Borrelia turicatae, an etiological agent of tick-borne relapsing fever. (8877131)
1996
29
An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. (7778052)
1995
30
Late relapse of tick-borne relapsing fever following treatment with doxycycline. (8434483)
1993
31
Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody. (1572965)
1992
32
Mortality in high risk patients with tick-borne relapsing fever analysed by the Borrelia-index. (1800081)
1991
33
Tick-borne relapsing fever in intravenous drug abusers. (2926174)
1989
34
Tick borne relapsing fever in Tanzanian children. (6498926)
1984
35
Single dose minocycline and doxycycline treatment of tick-borne relapsing fever. A double-blind clinical trial in Rwanda. (6365001)
1983
36
Congenital tick-borne relapsing fever: report of a case with first documentation of transplacental transmission. (7126796)
1982
37
Tick-borne relapsing fever in children. (7454488)
1980
38
Tick-borne relapsing fever in Colorado. Historical review and report of cases. (374757)
1979
39
Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park. (871120)
1977
40
Tick-borne relapsing fever in the Judean hills, including a case with massive haematuria. (5707919)
1968
41
Tick-borne relapsing fever in Kashmir: mice inoculation--a diagnostic method of choice. (4964791)
1967
42
A STUDY ON INDIAN TICK-BORNE RELAPSING FEVER. (14154432)
1964
43
CLINICAL PICTURE AND THERAPY OF TICK-BORNE RELAPSING FEVER; SUMMARY OF 49 CASES. (14243147)
1964
44
Tick-borne relapsing fever in Cyprus. (13010108)
1952
45
Tick-borne relapsing fever in Somaliland with special reference to the blood sedimentation rate. (14832869)
1951
46
Tick-borne relapsing fever on the Witwatersrand gold mines; its treatment with aureomycin. (15442582)
1950
47
Prevention of tick-borne relapsing fever. (15411885)
1950
48
Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. (18138841)
1949
49
On tick-borne relapsing fever]. (21000989)
1945
50
Tick-borne Relapsing Fever. (20786348)
1945

Variations for Tick-Borne Relapsing Fever

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Expression for genes affiliated with Tick-Borne Relapsing Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tick-Borne Relapsing Fever

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Pathways for genes affiliated with Tick-Borne Relapsing Fever

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Compounds for genes affiliated with Tick-Borne Relapsing Fever

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GO Terms for genes affiliated with Tick-Borne Relapsing Fever

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16Gene Ontology
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Cellular components related to Tick-Borne Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:0056628.7PURA, PURB
2nucleusGO:0056348.5ELK3, PURA, PURB

Biological processes related to Tick-Borne Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription from RNA polymerase II promoterGO:0063669.3ELK3, PURA
2regulation of transcription from RNA polymerase II promoterGO:0063579.0ELK3, PURA
3negative regulation of transcription, DNA-templatedGO:0458928.4ELK3, PURA, PURB

Molecular functions related to Tick-Borne Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1purine-rich negative regulatory element bindingGO:0324229.4ELK3, PURA
2sequence-specific DNA binding transcription factor activityGO:0037009.1ELK3, PURB
3SMAD bindingGO:0463329.0PURA, PURB
4single-stranded DNA bindingGO:0036978.9PURB, PURA
5transcription factor bindingGO:0081348.7PURA, PURB

Products for genes affiliated with Tick-Borne Relapsing Fever

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Tick-Borne Relapsing Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet