MCID: TNG003
MIFTS: 54

Tongue Cancer malady

Rare diseases, Cancer diseases categories
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Summaries for Tongue Cancer

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Wikipedia:65 Oral cancer or mouth cancer, a type of head and neck cancer, is any cancerous tissue growth located in... more...

MalaCards based summary: Tongue Cancer, also known as tongue carcinoma, is related to oral cancer and papilloma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Validated targets of C-MYC transcriptional activation. The compounds hoechst 33342 and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and lymph node, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Tongue Cancer

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Tongue Cancer, Aliases & Descriptions:

Name: Tongue Cancer 8 42 10 44
Tongue Carcinoma 42 44 62
Malignant Neoplasm of Ventral Tongue Surface Nos 8 62
Malignant Tumor of Anterior Two-Thirds of Tongue 8 62
Malignant Neoplasm of Mobile Part of Tongue Nos 8 62
Malignant Neoplasm of Ventral Surface of Tongue 8 62
Malignant Neoplasm of Junctional Zone of Tongue 8 62
Malignant Neoplasm of Fixed Part of Tongue Nos 8 62
Malignant Neoplasm of Dorsal Surface of Tongue 8 62
Malignant Neoplasm of Other Sites of Tongue 8 62
Malignant Neoplasm of Dorsal Tongue Nos 8 62
Malignant Neoplasm of Border of Tongue 8 62
Malignant Neoplasm of Lingual Tonsil 8 62
Malignant Neoplasm of Base of Tongue 8 62
Malignant Tumor of Posterior Tongue 8 62
 
Malignant Tumor of Base of Tongue 8 62
Malignant Neoplasm of Tongue 8 62
Malignant Tumor of Tongue 8 62
Malignant Neoplasm of Anterior Two-Thirds of Tongue, Part Unspecified 8
Malignant Neoplasm of Tip and/or Lateral Border of Tongue 8
Malignant Neoplasm of Anterior 2/3 of Tongue Unspecified 8
Malignant Neoplasm of Tip and Lateral Border of Tongue 8
Malignant Neoplasm of Tongue, Tip and Lateral Border 8
Tongue Neoplasm Malignant Stage Unspecified 8
Malignant Neoplasm of Dorsum of Tongue Nos 8
Malignant Tumor of Mobile Part of Tongue 8
Malignant Tumour of Lingual Tonsil 62
Malignant Neoplasm of Tongue, Nos 8
Malignant Tumor of Lingual Tonsil 8
Malignant Neoplasm of Tongue Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Tongue Cancer

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Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer30.2TERT, KRT13, CDKN1A
2papilloma30.0KRT13, CDKN1A
3tongue squamous cell carcinoma29.2TERT, EPOR, MT-CO2, BMI1, KRT13, CDKN1A
4leukemia28.9TERT, EPOR, PRLR, BMI1, KLRK1, CDKN1A
5cervicitis10.5
6endotheliitis10.2
7thyroid cancer, anaplastic10.2CDKN1A, TERT
8laryngeal squamous cell carcinoma10.2CDKN1A, TERT
9bladder carcinoma10.2TERT, CDKN1A
10hepatitis10.1
11tonsillitis10.1
12squamous cell carcinoma of the head and neck10.0CDKN1A, EPOR
13brain cancer10.0TERT, BMI1, CDKN1A
14osteosarcoma10.0TERT, MT-CO2, CDKN1A
15prostate cancer10.0CDKN1A, BMI1, TERT
16pancreatic cancer10.0CDKN1A, TERT
17graft versus host disease10.0
18glossopharyngeal neuralgia10.0
19necrotizing sialometaplasia10.0
20chronic graft versus host disease10.0
21leukoplakia10.0
22retinoblastoma10.0CDKN1A, BMI1, TERT
23cervical cancer10.0TERT, EPOR, CDKN1A
24obesity9.9
25rothmund-thomson syndrome9.9
26dyskeratosis congenita9.9
27oral candidiasis9.9
28neuroleptic malignant syndrome9.9
29hepatitis c9.9
30hypercalcemia9.9
31gastric ulcer9.9
32nasopharyngitis9.9
33candidiasis9.9
34herpes simplex9.9
35laryngitis9.9
36meningioma9.9
37periodontitis9.9
38sarcoma9.9
39warthin tumor9.9
40dysphagia9.9
41hypoxia9.9
42glioblastoma multiforme9.9CDKN1A, KLRK1, TERT
43colonic benign neoplasm9.9TERT, EPOR, CDKN1A
44acute leukemia9.9BMI1, EPOR, TERT
45adenoma9.9TERT, PRLR, KRT13, CDKN1A
46nasopharynx carcinoma9.9KRT13, KLRK1, TERT
47non-small cell lung carcinoma9.9CDKN1A, EPOR, TERT
48glioblastoma9.8TERT, PRLR, KLRK1, CDKN1A
49myeloma9.8EPOR, KLRK1, CDKN1A
50colorectal cancer9.7TERT, PRLR, KLRK1, CDKN1A

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Symptoms for Tongue Cancer

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Drugs & Therapeutics for Tongue Cancer

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Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Genetic Tests for Tongue Cancer

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Anatomical Context for Tongue Cancer

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MalaCards organs/tissues related to Tongue Cancer:

32
Tongue, Tonsil, Lymph node, Endothelial, Bone marrow, Bone, Liver, Lung

Animal Models for Tongue Cancer or affiliated genes

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MGI Mouse Phenotypes related to Tongue Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.0CDKN1A, BMI1, PRLR, TERT
2MP:00020068.5CDKN1A, KLRK1, BMI1, PRLR, TERT
3MP:00053848.4CDKN1A, BMI1, PRLR, EPOR, TERT
4MP:00053978.2TERT, EPOR, BMI1, KLRK1, CDKN1A
5MP:00053878.2TERT, EPOR, BMI1, KLRK1, CDKN1A
6MP:00036318.2TERT, EPOR, PRLR, BMI1, CDKN1A

Publications for Tongue Cancer

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Articles related to Tongue Cancer:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. (24993075)
2014
2
Correction: A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo. (25386757)
2014
3
High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer. (25040359)
2014
4
Comparative analysis of volumetric-modulated arc therapy and intensity-modulated radiotherapy for base of tongue cancer. (24872611)
2014
5
Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer. (25286028)
2014
6
Long-term results of brachytherapy in early mobile tongue cancer with 10-year minimal follow-up. (23267163)
2013
7
Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer. (24076185)
2013
8
Frontal meningioma incidentally detected in the routine preoperative assessment of tongue cancer: a case report and literature review. (24237778)
2013
9
Robot-assisted selective neck dissection via modified face-lift approach for early oral tongue cancer: a video demonstration. (22187119)
2012
10
The identification of significant chromosomal regions correlated with oral tongue cancer progression. (22638883)
2012
11
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. (21725369)
2012
12
Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. (22926477)
2012
13
Hepatic macronodular tuberculoma mimics liver metastasis in a patient with locoregional advanced tongue cancer. (21606414)
2011
14
Use of megavoltage computed tomography with image registration for high-dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shielding. (21349776)
2011
15
The role of the tumour microenvironment in the biology of head and neck cancer: lessons from mobile tongue cancer. (21455256)
2011
16
Survival and patterns of relapse in patients with oral tongue cancer. (19939533)
2010
17
The use of bioimpedance in the detection/screening of tongue cancer. (20097150)
2010
18
Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. (20939894)
2010
19
Surgical resection for oral tongue cancer pulmonary metastases. (20357009)
2010
20
The prognostic value of hypoxia markers in T2-staged oral tongue cancer. (18620902)
2009
21
Conditional survival rates of buccal and tongue cancer patients: how far does the benefit go? (18715814)
2009
22
Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. (19551891)
2009
23
Reconstruction of the tongue using an extended vertical lower trapezius island myocutaneous flap after removal of advanced tongue cancer. (18262315)
2008
24
Chronic periodontitis and the risk of tongue cancer. (17515503)
2007
25
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
26
Higher distant failure in young age tongue cancer patients. (16529977)
2006
27
A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. (15876484)
2006
28
Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001. (16669472)
2006
29
Immunohistochemical detection of cervical lymph node micrometastases from T2N0 tongue cancer. (16076716)
2005
30
Intraoral sonographic features of tongue cancer after radical radiotherapy. (15544902)
2004
31
Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. (12907203)
2003
32
Analysis of treatment results for oral tongue cancer. (12150512)
2002
33
Organ preservation with interstitial radiation for base of tongue cancer. (12393990)
2002
34
Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. (11886342)
2002
35
Frequent allelic loss/imbalance on the short arm of chromosome 3 in tongue cancer. (11806149)
2001
36
Tongue cancer in younger patients. (10901875)
1999
37
The quality of life of patients treated for tongue cancer. (9484951)
1998
38
Age as a prognostic factor for late local recurrence of early tongue cancer treated with brachytherapy. (9494593)
1997
39
Techniques for making spacers in interstitial brachytherapy for tongue cancer. (8630183)
1996
40
Supraglottic laryngeal or base of tongue cancer involving vallecula. (8936943)
1996
41
Quality of life after radiation therapy for base of tongue cancer. (8953585)
1996
42
Establishment and characterization of a human tongue cancer xenograft line in nude mice. (8935069)
1994
43
Circulating hormones in patients with tongue cancer. (21607386)
1994
44
Mast-cell frequency within tumor correlates to the stage of tongue cancer. (21607380)
1994
45
Circulating prolactin and TPS in monitoring the clinical course of male patients with metastatic tongue cancer: a preliminary study. (7682801)
1993
46
The prognostic value of cytometric DNA analysis in early stage tongue cancer. (1306730)
1992
47
Tongue cancer treated with irradiation: assessment with MR imaging. (1424445)
1992
48
Odontogenic sarcoma following radiation treatment of tongue cancer--a case report. (3233173)
1988
49
Recurrence patterns of mobile tongue cancer after radical neck dissection. (3760646)
1986
50
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978

Variations for Tongue Cancer

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Expression for genes affiliated with Tongue Cancer

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Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

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Compounds for genes affiliated with Tongue Cancer

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Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1hoechst 333424410.0CDKN1A, TERT
2depsipeptide449.9CDKN1A, TERT
3zidovudine44 50 1111.7MT-CO2, TERT
4butyrate449.7CDKN1A, PRLR, TERT
5methylcellulose449.7CDKN1A, EPOR
6ly294002449.5CDKN1A, EPOR, TERT
7wortmannin449.4TERT, EPOR, CDKN1A
8genistein44 28 61 2 24 1114.4CDKN1A, PRLR, TERT
9doxorubicin44 50 1111.4CDKN1A, EPOR, TERT
10thymidine44 2410.2TERT, EPOR, PRLR, CDKN1A
11cisplatin44 50 61 1111.9CDKN1A, EPOR, TERT
12phosphatidylinositol448.9TERT, EPOR, PRLR, KLRK1
13estrogen448.8CDKN1A, BMI1, PRLR, EPOR, TERT
14proline448.7EPOR, PRLR, KRT13
15retinoic acid44 249.6TERT, KLRK1, KRT13, CDKN1A
16oxygen44 249.5TERT, EPOR, MT-CO2, KLRK1, CDKN1A
17paraffin448.4CDKN1A, KRT13, PRLR, EPOR, TERT
18calcium44 50 24 1110.9TERT, EPOR, PRLR, KLRK1, KRT13

GO Terms for genes affiliated with Tongue Cancer

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Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of fibroblast proliferationGO:0481469.7CDKN1A, BMI1

Products for genes affiliated with Tongue Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Tongue Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet