MCID: TNG003
MIFTS: 52

Tongue Cancer malady

Rare diseases, Cancer diseases categories

Summaries for Tongue Cancer

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MalaCards based summary: Tongue Cancer, also known as tongue carcinoma, is related to oral cancer and tongue squamous cell carcinoma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Validated targets of C-MYC transcriptional activation. The compounds hoechst 33342 and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and lymph node, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Tongue Cancer

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Tongue Cancer, Aliases & Descriptions:

Name: Tongue Cancer 10 43 12 45
Tongue Carcinoma 43 45 62
Malignant Tumor of Anterior Two-Thirds of Tongue 10 62
Malignant Neoplasm of Ventral Tongue Surface Nos 10 62
Malignant Neoplasm of Junctional Zone of Tongue 10 62
Malignant Neoplasm of Ventral Surface of Tongue 10 62
Malignant Neoplasm of Mobile Part of Tongue Nos 10 62
Malignant Neoplasm of Dorsal Surface of Tongue 10 62
Malignant Neoplasm of Fixed Part of Tongue Nos 10 62
Malignant Neoplasm of Other Sites of Tongue 10 62
Malignant Neoplasm of Dorsal Tongue Nos 10 62
Malignant Neoplasm of Border of Tongue 10 62
Malignant Neoplasm of Base of Tongue 10 62
Malignant Neoplasm of Lingual Tonsil 10 62
Malignant Tumor of Posterior Tongue 10 62
 
Malignant Tumor of Base of Tongue 10 62
Malignant Neoplasm of Tongue 10 62
Malignant Tumor of Tongue 10 62
Malignant Neoplasm of Anterior Two-Thirds of Tongue, Part Unspecified 10
Malignant Neoplasm of Tip and/or Lateral Border of Tongue 10
Malignant Neoplasm of Anterior 2/3 of Tongue Unspecified 10
Malignant Neoplasm of Tip and Lateral Border of Tongue 10
Malignant Neoplasm of Tongue, Tip and Lateral Border 10
Tongue Neoplasm Malignant Stage Unspecified 10
Malignant Neoplasm of Dorsum of Tongue Nos 10
Malignant Tumor of Mobile Part of Tongue 10
Malignant Tumour of Lingual Tonsil 62
Malignant Tumor of Lingual Tonsil 10
Malignant Neoplasm of Tongue, Nos 10
Malignant Neoplasm of Tongue Nos 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Tongue Cancer

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Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer30.2TERT, KRT13, CDKN1A
2tongue squamous cell carcinoma30.1TERT, EPOR, MT-CO2, BMI1, KRT13, CDKN1A
3papilloma30.0KRT13, CDKN1A
4nasopharyngeal carcinoma29.9KRT13, KLRK1, TERT
5leukemia29.8TERT, EPOR, PRLR, BMI1, KLRK1, CDKN1A
6cervicitis10.5
7endotheliitis10.3
8hepatitis10.1
9thyroid cancer, anaplastic10.0CDKN1A, TERT
10laryngeal squamous cell carcinoma10.0CDKN1A, TERT
11bladder cancer, somatic10.0TERT, CDKN1A
12squamous cell carcinoma, head and neck10.0CDKN1A, EPOR
13brain cancer10.0TERT, BMI1, CDKN1A
14osteosarcoma, somatic10.0TERT, MT-CO2, CDKN1A
15prostate cancer10.0CDKN1A, BMI1, TERT
16pancreatic cancer10.0CDKN1A, TERT
17retinoblastoma10.0CDKN1A, BMI1, TERT
18cervical cancer, somatic10.0TERT, EPOR, CDKN1A
19glioblastoma multiforme10.0CDKN1A, KLRK1, TERT
20colorectal cancer10.0TERT, EPOR, CDKN1A
21acute leukemia10.0BMI1, EPOR, TERT
22adenoma10.0TERT, PRLR, KRT13, CDKN1A
23necrotizing sialometaplasia10.0
24glossopharyngeal neuralgia10.0
25chronic graft versus host disease10.0
26leukoplakia10.0
27lung cancer10.0CDKN1A, EPOR, TERT
28rheumatoid arthritis10.0
29rothmund-thomson syndrome10.0
30obesity10.0
31esophageal cancer10.0
32arthritis10.0
33hepatitis c10.0
34dyskeratosis congenita10.0
35gastric ulcer10.0
36nasopharyngitis10.0
37tonsillitis10.0
38hypercalcemia10.0
39oral candidiasis10.0
40fibrous dysplasia10.0
41neuroleptic malignant syndrome10.0
42candidiasis10.0
43esophagitis10.0
44herpes simplex10.0
45laryngitis10.0
46periodontitis10.0
47sarcoma10.0
48warthin tumor10.0
49dysphagia10.0
50hypoxia10.0

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Symptoms for Tongue Cancer

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Drugs & Therapeutics for Tongue Cancer

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Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Genetic Tests for Tongue Cancer

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Anatomical Context for Tongue Cancer

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MalaCards organs/tissues related to Tongue Cancer:

33
Tongue, Tonsil, Lymph node, Endothelial, Bone, Bone marrow, Liver, Lung

Animal Models for Tongue Cancer or affiliated genes

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MGI Mouse Phenotypes related to Tongue Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.0CDKN1A, BMI1, PRLR, TERT
2MP:00020068.5CDKN1A, KLRK1, BMI1, PRLR, TERT
3MP:00053848.4CDKN1A, BMI1, PRLR, EPOR, TERT
4MP:00053978.2TERT, EPOR, BMI1, KLRK1, CDKN1A
5MP:00053878.2TERT, EPOR, BMI1, KLRK1, CDKN1A
6MP:00036318.2TERT, EPOR, PRLR, BMI1, CDKN1A

Publications for Tongue Cancer

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Articles related to Tongue Cancer:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study. (25633184)
2015
2
Targeting HIF1I+ Peri-operatively Increased Post-surgery Survival in a Tongue Cancer Animal Model. (25564169)
2015
3
Characteristics of oral tongue and base of the tongue cancer: a hospital cancer registry based analysis. (25743801)
2015
4
Sentinel lymph node biopsy using computed tomographic lymphography in patients with early tongue cancer. (25761497)
2015
5
Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. (24993075)
2014
6
Correction: A Novel Compound NSC745885 Exerts an Anti-Tumor Effect on Tongue Cancer SAS Cells In Vitro and In Vivo. (25386757)
2014
7
High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer. (25040359)
2014
8
Comparative analysis of volumetric-modulated arc therapy and intensity-modulated radiotherapy for base of tongue cancer. (24872611)
2014
9
Severe Pulmonary Suppuration with Infection-Induced Systemic Inflammatory Response Syndrome following Tongue Cancer Surgery in a Patient Undergoing Tocilizumab Therapy for Rheumatoid Arthritis. (24872899)
2014
10
Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer. (25286028)
2014
11
Long-term results of brachytherapy in early mobile tongue cancer with 10-year minimal follow-up. (23267163)
2013
12
Robot-assisted selective neck dissection via modified face-lift approach for early oral tongue cancer: a video demonstration. (22187119)
2012
13
The identification of significant chromosomal regions correlated with oral tongue cancer progression. (22638883)
2012
14
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. (21725369)
2012
15
Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. (22926477)
2012
16
Hepatic macronodular tuberculoma mimics liver metastasis in a patient with locoregional advanced tongue cancer. (21606414)
2011
17
Use of megavoltage computed tomography with image registration for high-dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shielding. (21349776)
2011
18
The role of the tumour microenvironment in the biology of head and neck cancer: lessons from mobile tongue cancer. (21455256)
2011
19
Survival and patterns of relapse in patients with oral tongue cancer. (19939533)
2010
20
The use of bioimpedance in the detection/screening of tongue cancer. (20097150)
2010
21
The prognostic value of hypoxia markers in T2-staged oral tongue cancer. (18620902)
2009
22
Conditional survival rates of buccal and tongue cancer patients: how far does the benefit go? (18715814)
2009
23
Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. (19551891)
2009
24
Chronic periodontitis and the risk of tongue cancer. (17515503)
2007
25
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
26
Higher distant failure in young age tongue cancer patients. (16529977)
2006
27
A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. (15876484)
2006
28
Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001. (16669472)
2006
29
Immunohistochemical detection of cervical lymph node micrometastases from T2N0 tongue cancer. (16076716)
2005
30
Intraoral sonographic features of tongue cancer after radical radiotherapy. (15544902)
2004
31
Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. (12907203)
2003
32
Analysis of treatment results for oral tongue cancer. (12150512)
2002
33
Organ preservation with interstitial radiation for base of tongue cancer. (12393990)
2002
34
Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. (11886342)
2002
35
Frequent allelic loss/imbalance on the short arm of chromosome 3 in tongue cancer. (11806149)
2001
36
Tongue cancer in younger patients. (10901875)
1999
37
The quality of life of patients treated for tongue cancer. (9484951)
1998
38
Age as a prognostic factor for late local recurrence of early tongue cancer treated with brachytherapy. (9494593)
1997
39
Techniques for making spacers in interstitial brachytherapy for tongue cancer. (8630183)
1996
40
Supraglottic laryngeal or base of tongue cancer involving vallecula. (8936943)
1996
41
Quality of life after radiation therapy for base of tongue cancer. (8953585)
1996
42
Establishment and characterization of a human tongue cancer xenograft line in nude mice. (8935069)
1994
43
Circulating hormones in patients with tongue cancer. (21607386)
1994
44
Mast-cell frequency within tumor correlates to the stage of tongue cancer. (21607380)
1994
45
Circulating prolactin and TPS in monitoring the clinical course of male patients with metastatic tongue cancer: a preliminary study. (7682801)
1993
46
The prognostic value of cytometric DNA analysis in early stage tongue cancer. (1306730)
1992
47
Tongue cancer treated with irradiation: assessment with MR imaging. (1424445)
1992
48
Odontogenic sarcoma following radiation treatment of tongue cancer--a case report. (3233173)
1988
49
Recurrence patterns of mobile tongue cancer after radical neck dissection. (3760646)
1986
50
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978

Variations for Tongue Cancer

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Expression for genes affiliated with Tongue Cancer

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Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

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Compounds for genes affiliated with Tongue Cancer

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Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1hoechst 333424510.0CDKN1A, TERT
2depsipeptide459.9CDKN1A, TERT
3zidovudine45 51 1311.7MT-CO2, TERT
4butyrate459.7CDKN1A, PRLR, TERT
5methylcellulose459.7CDKN1A, EPOR
6ly294002459.5CDKN1A, EPOR, TERT
7wortmannin459.4TERT, EPOR, CDKN1A
8genistein45 30 61 3 26 1314.4CDKN1A, PRLR, TERT
9doxorubicin45 51 1311.4CDKN1A, EPOR, TERT
10thymidine45 2610.2TERT, EPOR, PRLR, CDKN1A
11cisplatin45 51 61 1311.9CDKN1A, EPOR, TERT
12phosphatidylinositol458.9TERT, EPOR, PRLR, KLRK1
13estrogen458.8CDKN1A, BMI1, PRLR, EPOR, TERT
14proline458.7EPOR, PRLR, KRT13
15retinoic acid45 269.6TERT, KLRK1, KRT13, CDKN1A
16oxygen45 269.5TERT, EPOR, MT-CO2, KLRK1, CDKN1A
17paraffin458.4CDKN1A, KRT13, PRLR, EPOR, TERT
18calcium45 51 26 1310.9TERT, EPOR, PRLR, KLRK1, KRT13

GO Terms for genes affiliated with Tongue Cancer

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Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of fibroblast proliferationGO:00481469.7CDKN1A, BMI1

Products for genes affiliated with Tongue Cancer

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  • Antibodies
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  • Kits and Assays

Sources for Tongue Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet