MCID: TNG003
MIFTS: 54

Tongue Cancer malady

Cancer diseases category

Summaries for Tongue Cancer

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63Wikipedia, 32MalaCards
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Wikipedia:63 Oral cancer or mouth cancer, a subtype of head and neck cancer, is any cancerous tissue growth located... more...

MalaCards: Tongue Cancer, also known as tongue carcinoma, is related to cervical cancer and squamous cell carcinoma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Angiogenesis and MicroRNAs in cancer. The compounds depsipeptide and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and salivary gland, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Tongue Cancer

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

tongue cancer 8 42 10 44
tongue carcinoma 42 44 60
malignant neoplasm of tongue 8 60
malignant neoplasm of anterior two-thirds of tongue, part unspecified 8
malignant neoplasm of tip and/or lateral border of tongue 8
malignant neoplasm of anterior 2/3 of tongue unspecified 8
malignant neoplasm of tip and lateral border of tongue 8
malignant neoplasm of tongue, tip and lateral border 8
malignant tumor of anterior two-thirds of tongue 8
malignant neoplasm of ventral tongue surface nos 8
malignant neoplasm of junctional zone of tongue 8
malignant neoplasm of mobile part of tongue nos 8
malignant neoplasm of ventral surface of tongue 8
malignant neoplasm of dorsal surface of tongue 8
malignant neoplasm of fixed part of tongue nos 8
malignant neoplasm of other sites of tongue 8
tongue neoplasm malignant stage unspecified 8
malignant neoplasm of dorsum of tongue nos 8
malignant tumor of mobile part of tongue 8
malignant neoplasm of dorsal tongue nos 8
malignant neoplasm of border of tongue 8
malignant neoplasm of lingual tonsil 8
malignant neoplasm of base of tongue 8
malignant tumor of posterior tongue 8
malignant neoplasm of tongue, nos 8
malignant tumor of lingual tonsil 8
malignant tumor of base of tongue 8
malignant neoplasm of tongue nos 8
malignant tumor of tongue 8


Related Diseases for Tongue Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer30.6CA9, CDKN1A, TERT
2squamous cell carcinoma30.3SERPINB5, VHL, CA9, WIBG, BMI1, MT-CO2
3lung cancer29.9CDKN1A
4sarcoma29.9SERPINB5, TERT, CA9
5leukemia29.8TERT, CDKN1A, PRLR, BMI1, KLRK1
6meningioma29.8TERT, PRLR
7lymph node cancer10.5
8cervicitis10.4
9tongue disease10.2
10vascular cancer10.2
11tonsil cancer10.1
12tonsillitis10.1
13hepatitis a10.1
14hepatitis10.1
15oral cancer10.0TERT, KRT13, CDKN1A
16endometriosis10.0PRLR, CD69
17myeloma10.0KLRK1, CDKN1A
18laryngeal benign neoplasm10.0SERPINB5, TERT
19endometrial carcinoma10.0TERT, CDKN1A, CA9
20colon cancer10.0SERPINB5, TERT, CDKN1A
21myelodysplastic syndromes10.0CD69, BMI1
22acute leukemia10.0TERT, BMI1
23osteosarcoma10.0MT-CO2, CDKN1A, TERT
24leukoplakia10.0KRT13
25hepatitis b10.0TERT
26glioblastoma multiforme10.0TERT, CDKN1A, VHL, KLRK1
27nasopharynx carcinoma10.0KLRK1, CA9, KRT13, TERT
28hepatocellular carcinoma10.0KLRK1, PRLR, CDKN1A, KRT13, TERT, SERPINB5
29adenoma10.0VHL, PRLR, CDKN1A, KRT13, TERT, SERPINB5
30colorectal cancer10.0CA9, CDKN1A, FXYD5, TERT, SERPINB5
31bladder carcinoma10.0SERPINB5, TERT, CDKN1A, CA9
32breast cancer10.0SERPINB5, TERT, CDKN1A, PRLR, BMI1, CA9
33stomach cancer10.0VHL, CDKN1A, TERT, SERPINB5
34renal clear cell carcinoma10.0CA9, VHL
35melanoma10.0KLRK1, CA9, BMI1, CDKN1A, FXYD5, TERT
36rheumatoid arthritis10.0KLRK1, PRLR, CD69, TERT
37burkitt's lymphoma10.0KLRC1, VHL, BMI1, PRLR, CD69, CDKN1A
38cholesteatoma10.0KRT13
39adenocarcinoma10.0KLRK1, VHL, CA9, PRLR, CDKN1A, KRT13
40pancreatic cancer10.0CDKN1A, TERT, SERPINB5
41prostate cancer10.0BMI1, CDKN1A, TERT, SERPINB5
42peritonitis10.0CD69
43malignant glioma10.0TERT, CDKN1A, CA9, VHL, KLRK1
44arthritis10.0CD69
45non-small cell lung carcinoma10.0TERT, CDKN1A, CA9
46psoriasis10.0KRT13, CD69
47ovarian cancer10.0SERPINB5, TERT, CDKN1A, VHL
48graft versus host disease9.9
49necrotizing sialometaplasia9.9
50glossopharyngeal neuralgia9.9

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Clinical Features for Tongue Cancer

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Drugs & Therapeutics for Tongue Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Search CenterWatch for Tongue Cancer

Genetic Tests for Tongue Cancer

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Anatomical Context for Tongue Cancer

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32MalaCards
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MalaCards organs/tissues related to Tongue Cancer:

32
Tongue, Tonsil, Salivary gland, Lymph node, Endothelial, Bone marrow, Lung, Bone, Liver, Prostate

Animal Models for Tongue Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tongue Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2TERT, CDKN1A, PRLR, BMI1, VHL, KLRK1
2MP:000538410.1VHL, BMI1, PRLR, CD69, CDKN1A, PFDN5
3MP:000537910.0CA9, BMI1, PRLR, CDKN1A, TERT

Publications for Tongue Cancer

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50PubMed
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Articles related to Tongue Cancer:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition. (23707970)
2013
2
Distinct epidemiologic characteristics of oral tongue cancer patients. (23396594)
2013
3
Tongue cancer subgroup. (23969642)
2013
4
Efficacy of multidrug superselective intra-arterial chemotherapy (docetaxel, cisplatin, and 5-fluorouracil) using the Seldinger technique for tongue cancer. (22998559)
2012
5
Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer. (22667997)
2012
6
Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer. (23342257)
2012
7
Purification and biochemical characterization of a novel protein-tongue cancer chemotherapy resistance-associated protein1 (TCRP1). (22365988)
2012
8
Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer. (23342263)
2012
9
GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer. (22905766)
2012
10
Use of megavoltage computed tomography with image registration for high-dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shielding. (21349776)
2011
11
Compartmental tongue surgery: Long term oncologic results in the treatment of tongue cancer. (21257337)
2011
12
Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer. (21112238)
2011
13
Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. (21903770)
2011
14
Aesthetic and functional radical surgery in young patients with stage one or two tongue cancer: a preliminary report. (20417110)
2011
15
Gastric ulcer revealed by computed tomography in a patient with tongue cancer after percutaneous gastrostomy. (21512620)
2011
16
Black hairy tongue associated with erlotinib treatment in a patient with advanced lung cancer. (22148027)
2011
17
COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. (21069476)
2011
18
Oral candidiasis mimicking tongue cancer. (21232886)
2011
19
Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer. (19804423)
2010
20
Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. (20372784)
2010
21
Quality of life of patients with tongue cancer 1 year after surgery. (20542366)
2010
22
Can synchronous chemotherapy be added to accelerated hypofractionated radiotherapy in patients with base of tongue cancer? (20116980)
2010
23
Conditional survival rates of buccal and tongue cancer patients: how far does the benefit go? (18715814)
2009
24
Cardiac metastasis of tongue cancer may cause sudden death. (17855031)
2008
25
Graves' ophthalmopathy and tongue cancer complicated by peg-interferon I+-2b and ribavirin therapy for chronic hepatitis C: A case report and review of the literature. (21479460)
2008
26
Treatment of base of tongue cancer with paclitaxel, ifosfamide, and cisplatinum induction chemotherapy followed by chemoradiotherapy. (18528311)
2008
27
Curative brachytherapy for recurrent/residual tongue cancer. (17340071)
2007
28
Re: Correlational of oral tongue cancer inversion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression, by Kim S-H, Cho NH, Kim K, et al. (16496361)
2006
29
Treatment results of stage I oral tongue cancer with definitive radiotherapy. (15878758)
2005
30
Correlating MRI and histologic tumor thickness in the assessment of oral tongue cancer. (14975989)
2004
31
Three-dimensional changes in lymphatic architecture around VX2 tongue cancer--dynamics of growth of cancer. (14552032)
2003
32
Results of low- and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer. (12972306)
2003
33
Clinical study of a spacer to help prevent osteoradionecrosis resulting from brachytherapy for tongue cancer. (12582367)
2003
34
Organ preservation with interstitial radiation for base of tongue cancer. (12393990)
2002
35
MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. (11567024)
2001
36
Influence of age on the results of brachytherapy for early tongue cancer. (11240233)
2001
37
High dose rate interstitial brachytherapy for mobile tongue cancer: Part 1. Phase I/II study of HDR hyperfractionated interstitial brachytherapy for oral cancer. (10895168)
2000
38
Tongue cancer in younger patients. (10901875)
1999
39
In vivo antitumor effects of electrochemotherapy in a tongue cancer model. (10437724)
1999
40
Oral glycopyrrolate alleviates drooling in a patient with tongue cancer. (10534970)
1999
41
Oral tongue cancer in patients less than 45 years old: institutional experience and comparison with older patients. (9469366)
1998
42
Functional reconstruction of the tongue and deglutition muscles following extensive resection of tongue cancer. (9734414)
1998
43
Techniques for making spacers in interstitial brachytherapy for tongue cancer. (8630183)
1996
44
Supraglottic laryngeal or base of tongue cancer involving vallecula. (8936943)
1996
45
Inhibitory effects of selenium, vitamin A and butylated hydroxytoluene on in vitro growth of human tongue cancer cells. (8719597)
1995
46
Circulating hormones in patients with tongue cancer. (21607386)
1994
47
Oral tongue cancer in young adults less than 40 years of age: rationale for aggressive therapy. (8021128)
1994
48
Circulating prolactin and TPS in monitoring the clinical course of male patients with metastatic tongue cancer: a preliminary study. (7682801)
1993
49
Suprahyoid pharyngotomy for oropharynx cancer including the tongue base. (1863441)
1991
50
Some considerations on radiation therapy of tongue cancer. (4105301)
1971

Genetic Variations for Tongue Cancer

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Expression for genes affiliated with Tongue Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

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4Cell Signaling Technology, 29KEGG
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Pathways related to Tongue Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SERPINB5, CA9, VHL
210.3SERPINB5, CDKN1A, MIR200B, MIR15B, BMI1

Compounds for genes affiliated with Tongue Cancer

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank
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Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1depsipeptide4410.5SERPINB5
25-aza-2deoxycytidine4410.5SERPINB5, TERT, CDKN1A, CA9, VHL
3paraffin4410.4CA9, PRLR, CDKN1A, KRT13, TERT, SERPINB5
4oxygen44 2411.3KLRK1, VHL, CA9, MT-CO2, CD69, CDKN1A
5estrogen4410.3VHL, CA9, BMI1, PRLR, CDKN1A, TERT
6tamoxifen44 49 28 1113.3CA9, PRLR, CDKN1A, SERPINB5
7rapamycin4410.2VHL, CA9, CDKN1A, TERT
8tyrosine4410.2VHL, CA9, PRLR, CD69, CDKN1A, TERT
9ly2940024410.0TERT, CDKN1A, CD69, VHL

GO Terms for genes affiliated with Tongue Cancer

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16Gene Ontology
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Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1morphogenesis of an epitheliumGO:00200910.4SERPINB5, CA9

Products for genes affiliated with Tongue Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tongue Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet