MCID: TNG003
MIFTS: 54

Tongue Cancer malady

Cancer diseases category

Summaries for Tongue Cancer

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Oral cancer or mouth cancer, a subtype of head and neck cancer, is any cancerous tissue growth located... more...

MalaCards: Tongue Cancer, also known as tongue carcinoma, is related to cervical cancer and squamous cell carcinoma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Angiogenesis and MicroRNAs in cancer. The compounds depsipeptide and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and salivary gland, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Tongue Cancer

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

tongue cancer 8 42 10 44
tongue carcinoma 42 44 60
malignant neoplasm of tongue 8 60
malignant neoplasm of anterior two-thirds of tongue, part unspecified 8
malignant neoplasm of tip and/or lateral border of tongue 8
malignant neoplasm of anterior 2/3 of tongue unspecified 8
malignant neoplasm of tip and lateral border of tongue 8
malignant neoplasm of tongue, tip and lateral border 8
malignant tumor of anterior two-thirds of tongue 8
malignant neoplasm of ventral tongue surface nos 8
malignant neoplasm of junctional zone of tongue 8
malignant neoplasm of mobile part of tongue nos 8
malignant neoplasm of ventral surface of tongue 8
malignant neoplasm of dorsal surface of tongue 8
malignant neoplasm of fixed part of tongue nos 8
malignant neoplasm of other sites of tongue 8
tongue neoplasm malignant stage unspecified 8
malignant neoplasm of dorsum of tongue nos 8
malignant tumor of mobile part of tongue 8
malignant neoplasm of dorsal tongue nos 8
malignant neoplasm of border of tongue 8
malignant neoplasm of lingual tonsil 8
malignant neoplasm of base of tongue 8
malignant tumor of posterior tongue 8
malignant neoplasm of tongue, nos 8
malignant tumor of lingual tonsil 8
malignant tumor of base of tongue 8
malignant neoplasm of tongue nos 8
malignant tumor of tongue 8


Related Diseases for Tongue Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1cervical cancer30.6CA9, CDKN1A, TERT
2squamous cell carcinoma30.3SERPINB5, VHL, CA9, WIBG, BMI1, MT-CO2
3lung cancer29.9CDKN1A
4sarcoma29.9SERPINB5, TERT, CA9
5leukemia29.8TERT, CDKN1A, PRLR, BMI1, KLRK1
6meningioma29.8TERT, PRLR
7lymph node cancer10.5
8cervicitis10.4
9tongue disease10.2
10vascular cancer10.2
11tonsil cancer10.1
12tonsillitis10.1
13hepatitis a10.1
14hepatitis10.1
15oral cancer10.0TERT, KRT13, CDKN1A
16endometriosis10.0PRLR, CD69
17myeloma10.0KLRK1, CDKN1A
18laryngeal benign neoplasm10.0SERPINB5, TERT
19endometrial carcinoma10.0TERT, CDKN1A, CA9
20colon cancer10.0SERPINB5, TERT, CDKN1A
21myelodysplastic syndromes10.0CD69, BMI1
22acute leukemia10.0TERT, BMI1
23osteosarcoma10.0MT-CO2, CDKN1A, TERT
24leukoplakia10.0KRT13
25hepatitis b10.0TERT
26glioblastoma multiforme10.0TERT, CDKN1A, VHL, KLRK1
27nasopharynx carcinoma10.0KLRK1, CA9, KRT13, TERT
28hepatocellular carcinoma10.0KLRK1, PRLR, CDKN1A, KRT13, TERT, SERPINB5
29adenoma10.0VHL, PRLR, CDKN1A, KRT13, TERT, SERPINB5
30colorectal cancer10.0CA9, CDKN1A, FXYD5, TERT, SERPINB5
31bladder carcinoma10.0SERPINB5, TERT, CDKN1A, CA9
32breast cancer10.0SERPINB5, TERT, CDKN1A, PRLR, BMI1, CA9
33stomach cancer10.0VHL, CDKN1A, TERT, SERPINB5
34renal clear cell carcinoma10.0CA9, VHL
35melanoma10.0KLRK1, CA9, BMI1, CDKN1A, FXYD5, TERT
36rheumatoid arthritis10.0KLRK1, PRLR, CD69, TERT
37burkitt's lymphoma10.0KLRC1, VHL, BMI1, PRLR, CD69, CDKN1A
38cholesteatoma10.0KRT13
39adenocarcinoma10.0KLRK1, VHL, CA9, PRLR, CDKN1A, KRT13
40pancreatic cancer10.0CDKN1A, TERT, SERPINB5
41prostate cancer10.0BMI1, CDKN1A, TERT, SERPINB5
42peritonitis10.0CD69
43malignant glioma10.0TERT, CDKN1A, CA9, VHL, KLRK1
44arthritis10.0CD69
45non-small cell lung carcinoma10.0TERT, CDKN1A, CA9
46psoriasis10.0KRT13, CD69
47ovarian cancer10.0SERPINB5, TERT, CDKN1A, VHL
48graft versus host disease9.9
49necrotizing sialometaplasia9.9
50glossopharyngeal neuralgia9.9

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Clinical Features for Tongue Cancer

About this section

Drugs & Therapeutics for Tongue Cancer

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tongue Cancer

Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Search CenterWatch for Tongue Cancer

Genetic Tests for Tongue Cancer

About this section

Anatomical Context for Tongue Cancer

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Tongue Cancer:

32
Tongue, Tonsil, Salivary gland, Lymph node, Endothelial, Lung, Bone, Bone marrow, Liver, Prostate

Animal Models for Tongue Cancer or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Tongue Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2TERT, CDKN1A, PRLR, BMI1, VHL, KLRK1
2MP:000538410.1VHL, BMI1, PRLR, CD69, CDKN1A, PFDN5
3MP:000537910.0CA9, BMI1, PRLR, CDKN1A, TERT

Publications for Tongue Cancer

About this section
Sources:
50PubMed
See all sources

Articles related to Tongue Cancer:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer. (24076185)
2013
2
Long-term outcomes with high-dose-rate brachytherapy for the management of base of tongue cancer. (23988507)
2013
3
Tongue strength as a predictor of functional outcomes and quality of life after tongue cancer surgery. (23837392)
2013
4
Early stage oral tongue cancer among non-tobacco users--an increasing trend observed in a South Indian patient population presenting at a single centre. (24175776)
2013
5
Relationships between Tumor Volume and Lymphatic Metastasis and Prognosis in Early Oral Tongue Cancer. (24353865)
2013
6
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. (21725369)
2012
7
A mutation at IVS1 + 5 of the von Hippel-Lindau gene resulting in intron retention in transcripts is not pathogenic in a patient with a tongue cancer?: case report. (22462637)
2012
8
Prevalence of human papillomavirus in mobile tongue cancer with particular reference to young patients. (22070675)
2012
9
Dosimetric distribution to the tooth-bearing regions of the mandible following intensity-modulated radiation therapy for base of tongue cancer. (22769422)
2012
10
The prognostic importance of midline involvement in oral tongue cancer. (21701377)
2012
11
Suspension of the tongue to the digastric tendon following resection of the anterior mandibular arch for oral cancer prevents postoperative tongue fall and avoids the need for tracheostomy. (22842162)
2012
12
Hepatic macronodular tuberculoma mimics liver metastasis in a patient with locoregional advanced tongue cancer. (21606414)
2011
13
The role of the tumour microenvironment in the biology of head and neck cancer: lessons from mobile tongue cancer. (21455256)
2011
14
Lentivirus-mediated gene silencing of beta-catenin inhibits growth of human tongue cancer cells. (21352379)
2011
15
High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancer. (21610708)
2011
16
Significance of tumor satellite variables in reflecting the epithelial-mesenchymal transition of tongue cancer. (21664858)
2011
17
The use of bioimpedance in the detection/screening of tongue cancer. (20097150)
2010
18
Surgical resection for oral tongue cancer pulmonary metastases. (20357009)
2010
19
Outcomes of oral tongue cancer: does age matter? (21274485)
2010
20
Dismissing links between HPV and aggressive tongue cancer in young patients. (19825879)
2010
21
Trends in the incidence rates of tonsil and base of tongue cancer in England, 1985-2006. (20615309)
2010
22
Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I). (20637681)
2010
23
Metastatic neck disease beyond the limits of a neck dissection: attention to the 'para-hyoid' area in T1/2 oral tongue cancer. (19213806)
2009
24
FDG-positive Warthin's tumors in cervical lymph nodes mimicking metastases in tongue cancer staging with PET/CT. (19130980)
2009
25
Sympathectomy suppresses tumor growth and alters gene-expression profiles in rat tongue cancer. (19627344)
2009
26
Quality of life related to swallowing after tongue cancer treatment. (17999111)
2008
27
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. (18253113)
2008
28
The study of apoptosis induction effect of vitamin E succinate on Tca8113 human tongue cancer cells]. (18780489)
2008
29
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo. (18282784)
2008
30
Comparison of three major radioactive sources for brachytherapy used in the treatment of node negative T1-T3 oral tongue cancer: influence of age on outcome. (17348432)
2007
31
Factors influencing postoperative speech function of tongue cancer patients following reconstruction with fasciocutaneous/myocutaneous flaps--a multicenter study. (17363217)
2007
32
Elective neck irradiation on ipsilateral side in patients with early tongue cancer for high-risk group with late cervical lymph node metastasis. (16579176)
2006
33
Induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil for tongue cancer. (15342966)
2004
34
Multivariate predictors of occult neck metastasis in early oral tongue cancer. (15467620)
2004
35
Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients. (15386365)
2004
36
The gamma2 chain of laminin-5 as an indicator of increased risk for recurrence in T1 stage tongue cancer. (15510597)
2004
37
Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. (12907203)
2003
38
Is ipsilateral radiation for tonsil cancer with limited tongue extension or T2N1 tonsil cancer without tongue involvement appropriate? (12183007)
2002
39
Base-of-tongue cancer: survival, function, and quality of life after external-beam irradiation and brachytherapy. (11568569)
2001
40
Differential expression of cytokeratin after orthotopic implantation of newly established human tongue cancer cell lines of defined metastatic ability. (10751357)
2000
41
The epidemiology of tongue cancer: a review of global incidence. (10702783)
2000
42
Lymph node metastases in hamster tongue cancer induced with 9,10-dimethyl-1,2-benzanthracene: association between histological findings and the incidence of neck metastases, and the clinical implications for patients with tongue cancer. (10203219)
1999
43
Phase III trial of high and low dose rate interstitial radiotherapy for early oral tongue cancer. (8985043)
1996
44
Mast-cell frequency within tumor correlates to the stage of tongue cancer. (21607380)
1994
45
Tumor thickness in early tongue cancer. (8018323)
1994
46
Causes of oral tongue cancer treatment failures. Analysis of autopsy cases. (1739904)
1992
47
Tongue and tonsil cancer: staging with US. (3511504)
1986
48
Radiotherapy of oral tongue cancer. (6797118)
1981
49
Therapeutic effects of radon seed implantation on tongue cancer]. (5249368)
1968
50
A survey of tongue cancer over a fifteen year period in a general hospital. (13495850)
1958

Genetic Variations for Tongue Cancer

About this section

Expression for genes affiliated with Tongue Cancer

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

About this section
Sources:
4Cell Signaling Technology, 29KEGG
See all sources

Pathways related to Tongue Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SERPINB5, CA9, VHL
210.3SERPINB5, CDKN1A, MIR200B, MIR15B, BMI1

Compounds for genes affiliated with Tongue Cancer

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank
See all sources

Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1depsipeptide4410.5SERPINB5
25-aza-2deoxycytidine4410.5SERPINB5, TERT, CDKN1A, CA9, VHL
3paraffin4410.4CA9, PRLR, CDKN1A, KRT13, TERT, SERPINB5
4oxygen44 2411.3KLRK1, VHL, CA9, MT-CO2, CD69, CDKN1A
5estrogen4410.3VHL, CA9, BMI1, PRLR, CDKN1A, TERT
6tamoxifen44 49 28 1113.3CA9, PRLR, CDKN1A, SERPINB5
7rapamycin4410.2VHL, CA9, CDKN1A, TERT
8tyrosine4410.2VHL, CA9, PRLR, CD69, CDKN1A, TERT
9ly2940024410.0TERT, CDKN1A, CD69, VHL

GO Terms for genes affiliated with Tongue Cancer

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1morphogenesis of an epitheliumGO:00200910.4SERPINB5, CA9

Products for genes affiliated with Tongue Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tongue Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet