MCID: TNG003
MIFTS: 53

Tongue Cancer malady

Rare diseases, Cancer diseases categories

Summaries for Tongue Cancer

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66Wikipedia, 34MalaCards
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Wikipedia:66 Oral cancer or mouth cancer, a type of head and neck cancer, is any cancerous tissue growth located in... more...

MalaCards: Tongue Cancer, also known as tongue carcinoma, is related to oral cancer and tongue squamous cell carcinoma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Validated targets of C-MYC transcriptional activation. The compounds hoechst 33342 and depsipeptide have been mentioned in the context of this disorder. Affiliated tissues include tongue, tonsil and lymph node, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Tongue Cancer

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

tongue cancer 9 44 11 46
tongue carcinoma 44 46 63
malignant neoplasm of tongue 9 63
malignant neoplasm of anterior two-thirds of tongue, part unspecified 9
malignant neoplasm of tip and/or lateral border of tongue 9
malignant neoplasm of anterior 2/3 of tongue unspecified 9
malignant neoplasm of tip and lateral border of tongue 9
malignant neoplasm of tongue, tip and lateral border 9
malignant tumor of anterior two-thirds of tongue 9
malignant neoplasm of ventral tongue surface nos 9
malignant neoplasm of mobile part of tongue nos 9
malignant neoplasm of junctional zone of tongue 9
malignant neoplasm of ventral surface of tongue 9
malignant neoplasm of dorsal surface of tongue 9
malignant neoplasm of fixed part of tongue nos 9
malignant neoplasm of other sites of tongue 9
tongue neoplasm malignant stage unspecified 9
malignant neoplasm of dorsum of tongue nos 9
malignant tumor of mobile part of tongue 9
malignant neoplasm of dorsal tongue nos 9
malignant neoplasm of border of tongue 9
malignant neoplasm of lingual tonsil 9
malignant neoplasm of base of tongue 9
malignant tumor of posterior tongue 9
malignant tumor of base of tongue 9
malignant neoplasm of tongue, nos 9
malignant tumor of lingual tonsil 9
malignant neoplasm of tongue nos 9
malignant tumor of tongue 9


Related Diseases for Tongue Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer29.9TERT, KRT13, CDKN1A
2tongue squamous cell carcinoma29.9TERT, EPOR, MT-CO2, BMI1, KRT13, CDKN1A
3papilloma29.9KRT13, CDKN1A
4leukemia29.6TERT, EPOR, PRLR, BMI1, KLRK1, CDKN1A
5cervicitis10.4
6endotheliitis10.2
7tonsillitis10.1
8hepatitis10.1
9thyroid cancer, anaplastic10.0CDKN1A, TERT
10laryngeal squamous cell carcinoma10.0CDKN1A, TERT
11bladder carcinoma10.0TERT, CDKN1A
12pancreatic cancer10.0CDKN1A, TERT
13brain cancer10.0TERT, BMI1, CDKN1A
14osteosarcoma10.0TERT, MT-CO2, CDKN1A
15prostate cancer10.0CDKN1A, BMI1, TERT
16cervical cancer10.0TERT, EPOR, CDKN1A
17retinoblastoma10.0CDKN1A, BMI1, TERT
18squamous cell carcinoma of the head and neck10.0EPOR, KRT13, CDKN1A
19glioblastoma multiforme10.0CDKN1A, KLRK1, TERT
20acute leukemia10.0BMI1, EPOR, TERT
21colon cancer10.0TERT, EPOR, CDKN1A
22adenoma10.0TERT, PRLR, KRT13, CDKN1A
23graft versus host disease10.0
24necrotizing sialometaplasia10.0
25glossopharyngeal neuralgia10.0
26chronic graft versus host disease10.0
27leukoplakia10.0
28nasopharynx carcinoma10.0KRT13, KLRK1, TERT
29non-small cell lung carcinoma10.0CDKN1A, EPOR, TERT
30myeloma9.9EPOR, KLRK1, CDKN1A
31colorectal cancer9.9TERT, PRLR, KLRK1, CDKN1A
32hepatitis c9.9
33rothmund-thomson syndrome9.9
34dyskeratosis congenita9.9
35gastric ulcer9.9
36nasopharyngitis9.9
37hypercalcemia9.9
38oral candidiasis9.9
39neuroleptic malignant syndrome9.9
40candidiasis9.9
41herpes simplex9.9
42laryngitis9.9
43meningioma9.9
44periodontitis9.9
45sarcoma9.9
46warthin tumor9.9
47hypoxia9.9
48lung cancer9.9TERT, KLRK1, KRT13, CDKN1A
49stomach cancer9.9CDKN1A, KLRK1, EPOR, TERT
50malignant glioma9.9CDKN1A, KLRK1, EPOR, TERT

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Symptoms for Tongue Cancer

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Drugs & Therapeutics for Tongue Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Tongue Cancer

Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Search CenterWatch for Tongue Cancer

Genetic Tests for Tongue Cancer

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Anatomical Context for Tongue Cancer

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34MalaCards
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MalaCards organs/tissues related to Tongue Cancer:

34
Tongue, Tonsil, Lymph node, Endothelial, Bone, Bone marrow, Liver, Lung

Animal Models for Tongue Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Tongue Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.0CDKN1A, BMI1, PRLR, TERT
2MP:00020068.5CDKN1A, KLRK1, BMI1, PRLR, TERT
3MP:00053848.4CDKN1A, BMI1, PRLR, EPOR, TERT
4MP:00053978.2TERT, EPOR, BMI1, KLRK1, CDKN1A
5MP:00053878.2TERT, EPOR, BMI1, KLRK1, CDKN1A
6MP:00036318.2TERT, EPOR, PRLR, BMI1, CDKN1A

Publications for Tongue Cancer

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Sources:
53PubMed
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Articles related to Tongue Cancer:

(show top 50)    (show all 335)
idTitleAuthorsYear
1
Long-term results of brachytherapy in early mobile tongue cancer with 10-year minimal follow-up. (23267163)
2013
2
Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer. (24076185)
2013
3
Frontal meningioma incidentally detected in the routine preoperative assessment of tongue cancer: a case report and literature review. (24237778)
2013
4
Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition. (23707970)
2013
5
Robot-assisted selective neck dissection via modified face-lift approach for early oral tongue cancer: a video demonstration. (22187119)
2012
6
The identification of significant chromosomal regions correlated with oral tongue cancer progression. (22638883)
2012
7
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. (21725369)
2012
8
Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. (22926477)
2012
9
Hepatic macronodular tuberculoma mimics liver metastasis in a patient with locoregional advanced tongue cancer. (21606414)
2011
10
Use of megavoltage computed tomography with image registration for high-dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shielding. (21349776)
2011
11
The role of the tumour microenvironment in the biology of head and neck cancer: lessons from mobile tongue cancer. (21455256)
2011
12
Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry. (20969624)
2011
13
Human papillomavirus and survival in patients with base of tongue cancer. (20725995)
2011
14
Survival and patterns of relapse in patients with oral tongue cancer. (19939533)
2010
15
The use of bioimpedance in the detection/screening of tongue cancer. (20097150)
2010
16
Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. (20939894)
2010
17
Surgical resection for oral tongue cancer pulmonary metastases. (20357009)
2010
18
The prognostic value of hypoxia markers in T2-staged oral tongue cancer. (18620902)
2009
19
Conditional survival rates of buccal and tongue cancer patients: how far does the benefit go? (18715814)
2009
20
Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. (19551891)
2009
21
Reconstruction of the tongue using an extended vertical lower trapezius island myocutaneous flap after removal of advanced tongue cancer. (18262315)
2008
22
TUNEL as a tumor marker of tongue cancer. (19031943)
2008
23
Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. (18072267)
2008
24
Chronic periodontitis and the risk of tongue cancer. (17515503)
2007
25
Significance of tumour volume measurements in tongue cancer: a novel role in staging. (17635274)
2007
26
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)
2006
27
Higher distant failure in young age tongue cancer patients. (16529977)
2006
28
A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. (15876484)
2006
29
Immunohistochemical detection of cervical lymph node micrometastases from T2N0 tongue cancer. (16076716)
2005
30
Intraoral sonographic features of tongue cancer after radical radiotherapy. (15544902)
2004
31
Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. (12907203)
2003
32
Analysis of treatment results for oral tongue cancer. (12150512)
2002
33
Organ preservation with interstitial radiation for base of tongue cancer. (12393990)
2002
34
Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. (11886342)
2002
35
Frequent allelic loss/imbalance on the short arm of chromosome 3 in tongue cancer. (11806149)
2001
36
Tongue cancer in younger patients. (10901875)
1999
37
The quality of life of patients treated for tongue cancer. (9484951)
1998
38
Age as a prognostic factor for late local recurrence of early tongue cancer treated with brachytherapy. (9494593)
1997
39
Techniques for making spacers in interstitial brachytherapy for tongue cancer. (8630183)
1996
40
Supraglottic laryngeal or base of tongue cancer involving vallecula. (8936943)
1996
41
Quality of life after radiation therapy for base of tongue cancer. (8953585)
1996
42
Establishment and characterization of a human tongue cancer xenograft line in nude mice. (8935069)
1994
43
Circulating hormones in patients with tongue cancer. (21607386)
1994
44
Mast-cell frequency within tumor correlates to the stage of tongue cancer. (21607380)
1994
45
Circulating prolactin and TPS in monitoring the clinical course of male patients with metastatic tongue cancer: a preliminary study. (7682801)
1993
46
The prognostic value of cytometric DNA analysis in early stage tongue cancer. (1306730)
1992
47
Tongue cancer treated with irradiation: assessment with MR imaging. (1424445)
1992
48
Odontogenic sarcoma following radiation treatment of tongue cancer--a case report. (3233173)
1988
49
Recurrence patterns of mobile tongue cancer after radical neck dissection. (3760646)
1986
50
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978

Variations for Tongue Cancer

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Expression for genes affiliated with Tongue Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 13EMD Millipore, 61Thomson Reuters, 31KEGG
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Compounds for genes affiliated with Tongue Cancer

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1hoechst 333424610.0CDKN1A, TERT
2depsipeptide469.9CDKN1A, TERT
3zidovudine46 52 1211.7MT-CO2, TERT
4butyrate469.7CDKN1A, PRLR, TERT
5methylcellulose469.7CDKN1A, EPOR
6ly294002469.5CDKN1A, EPOR, TERT
7wortmannin469.4TERT, EPOR, CDKN1A
8genistein46 30 62 3 25 1214.4CDKN1A, PRLR, TERT
9doxorubicin46 52 1211.4CDKN1A, EPOR, TERT
10thymidine46 2510.2TERT, EPOR, PRLR, CDKN1A
11cisplatin46 52 62 1211.9CDKN1A, EPOR, TERT
12phosphatidylinositol468.9TERT, EPOR, PRLR, KLRK1
13estrogen468.8CDKN1A, BMI1, PRLR, EPOR, TERT
14proline468.7EPOR, PRLR, KRT13
15retinoic acid46 259.6TERT, KLRK1, KRT13, CDKN1A
16oxygen46 259.5TERT, EPOR, MT-CO2, KLRK1, CDKN1A
17paraffin468.4CDKN1A, KRT13, PRLR, EPOR, TERT
18calcium46 52 25 1210.9TERT, EPOR, PRLR, KLRK1, KRT13

GO Terms for genes affiliated with Tongue Cancer

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17Gene Ontology
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Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of fibroblast proliferationGO:0481469.7CDKN1A, BMI1

Products for genes affiliated with Tongue Cancer

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Sources for Tongue Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet