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Tongue Cancer malady
59 genes, 6 tissues, 925 related diseases, 26 phenotypes, 45 articles, clinical trials.

Summaries for Tongue Cancer

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44Wikipedia, 22MalaCards
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Wikipedia: Oral cancer is a subtype of head and neck cancer, is any cancerous tissue growth located in the oral...44 more...

MalaCards: Tongue Cancer, also known as malignant neoplasm of tongue, is related to salivary gland cancer and nasopharynx carcinoma. An important gene associated with Tongue Cancer is FAM168A (family with sequence similarity 168, member A), and among its related pathways are Signal transduction_PTEN pathway and Signal transduction PTEN pathway. The compounds egcg and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, salivary gland and tonsil, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Aliases & Descriptions for Tongue Cancer

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6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 19ICD9CM, 27NCIt, 24MeSH
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Aliases & Descriptions:

tongue cancer 6 30 8 32
malignant neoplasm of tongue 6 43
tongue carcinoma 30 32
malignant neoplasm of anterior two-thirds of tongue, part unspecified 6
malignant neoplasm of anterior 2/3 of tongue unspecified (disorder) 6
malignant neoplasm of tongue, tip and lateral border (disorder) 6
malignant neoplasm of ventral tongue surface nos (disorder) 6
malignant tumor of anterior two-thirds of tongue (disorder) 6
malignant neoplasm of tip and/or lateral border of tongue 6
malignant neoplasm of fixed part of tongue nos (disorder) 6
malignant neoplasm of tip and lateral border of tongue 6
malignant neoplasm of other sites of tongue (disorder) 6
malignant neoplasm of dorsum of tongue nos (disorder) 6
malignant neoplasm of junctional zone of tongue 6
malignant neoplasm of ventral surface of tongue 6
malignant neoplasm of mobile part of tongue nos 6
malignant neoplasm of dorsal surface of tongue 6
malignant neoplasm of fixed part of tongue nos 6
malignant tumor of base of tongue (disorder) 6
malignant tumor of lingual tonsil (disorder) 6
malignant neoplasm of other sites of tongue 6
malignant neoplasm of tongue nos (disorder) 6
tongue neoplasm malignant stage unspecified 6
malignant tumor of mobile part of tongue 6
malignant neoplasm of dorsal tongue nos 6
malignant neoplasm of border of tongue 6
malignant neoplasm of base of tongue 6
malignant tumor of tongue (disorder) 6
malignant neoplasm of lingual tonsil 6
malignant tumor of posterior tongue 6
malignant tumor of lingual tonsil 6
malignant neoplasm of tongue, nos 6
malignant neoplasm of tongue nos 6
malignant neoplasms 43
tongue neoplasms 43

Related Diseases for Tongue Cancer

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13GeneCards, 14GeneDecks
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Diseases related to tongue cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 922)
idRelated DiseaseScoreTop Affiliating Genes
1salivary gland cancer32.1SERPINB5, BIRC5, MMP9, FAS, HIF1A
2nasopharynx carcinoma31.6VEGFA, CDKN2A, CDH1, MMP9, TP53
3squamous cell carcinoma30.2CD44, CDH1, MKI67, PTK2, EPCAM
4pancreatic cancer29.8SERPINB5, VEGFA, BIRC5, CDKN1A, FHIT, TERT
5malignant peripheral nerve sheath tumor29.2VIM, CDKN2A, TERT, SLC2A1
6stomach carcinoma29.1CDKN2A, CD44, CDH1, FAS
7cardia cancer29.0CDKN2A, CD44, TP53
8pancreatic ductal carcinoma28.7VEGFA, CDKN2A, MMP9, TP53
9brain cancer28.4VEGFA, BIRC5, CDKN1A, CD44, HPSE, TP53
10fallopian tube carcinoma28.1MYC, MKI67, TP53
11male breast cancer27.8PCNA, TP53, PTEN, PRL
12breast cancer27.7VEGFA, BCL2, MMP1, MMP2, MMP9, IL8
13cervix carcinoma27.6MYC, CDKN1A, CDKN2A, CD44, MKI67, TP53
14prostate carcinoma27.2VEGFA, CDH1, MMP9, TP53, TERT, PTEN
15anaplastic carcinoma27.2VIM, CDH1, FHIT, SLC2A1
16oropharyngeal cancer, adult27.1CDKN2A, MMP8, TP53
17kidney cancer27.1VHL, VEGFA, CDKN1A, FHIT, CA9, TP53
18pulmonary blastoma27.1VIM, TP53, CTNNB1
19thyroid cancer, anaplastic26.9CDKN1A, CDH1, TP53, TERT, PTEN, CTNNB1
20non-hodgkin lymphoma26.7MYC, BIRC5, BCL2, CDK1, CD44, FAS
21verrucous carcinoma26.7PCNA, CDKN1A, CDKN2A, CD44, CDH1, TP53
22multiple endocrine neoplasia26.6VHL, CDKN1A, CDH2, CDKN2A, CDH1, PTEN
23familial colorectal cancer26.6BCL2, CDKN2A, CDH1, TP53, SLC10A2
24acute lymphoblastic leukemia26.5BCL2, CDKN2A, CDK1, FHIT, ENG, NOTCH1
25letterer-siwe disease26.3MKI67, TP53, NOTCH1, PRL
26urinary bladder cancer26.3SERPINB5, BIRC5, CDKN1A, CDH2, CDKN2A, CDH1
27liver cancer26.1SERPINB5, VEGFA, MYC, BIRC5, BCL2, BAX
28angiomyolipoma26.0VIM, MYC, CDKN2A, TP53
29testicular cancer26.0CDKN1A, CDH1, MMP2, MMP9, MKI67, FAS
30anaplastic large cell lymphoma25.2PCNA, MYC, BIRC5, BCL2, CDKN1A, CD44
31seminoma25.1VIM, MYC, BCL2, BAX, FAS, TP53
32adrenocortical tumor25.0VHL, VEGFA, MYC, CDKN2A, MMP2, MKI67
33skin cancer25.0PCNA, VIM, BIRC5, BCL2, BAX, CDKN2A
34angiosarcoma24.8VIM, VEGFA, MYC, CDKN2A, ENG, TP53
35leukemia/lymphoma24.6PDCD1, VEGFA, MYC, BCL2, CDKN2A, CD44
36cystadenocarcinoma24.4PCNA, VIM, VEGFA, BIRC5, BCL2, BAX
37thyroid cancer, follicular24.3VIM, VHL, VEGFA, CDH1, MMP9, TP53
38glioblastoma24.1VHL, VEGFA, BIRC5, BAX, CDKN1A, CDKN2A
39herpes simplex23.5PCNA, VIM, VEGFA, MYC, BCL2, BAX
40esophageal cancer23.2PCNA, VHL, VEGFA, MYC, BIRC5, BCL2
41gallbladder carcinoma22.8PCNA, SERPINB5, VEGFA, BCL2, CDKN2A, CD44
42gastrointestinal stromal tumor22.1PCNA, SERPINB5, VIM, VEGFA, BCL2, BAX
43prostate cancer, progression of21.6PCNA, SERPINB5, VEGFA, BCL2, BAX, CDKN1A
44lymphoblastic leukemia21.3PCNA, VEGFA, MYC, BIRC5, BCL2, BAX
45ductal carcinoma in situ21.1PCNA, VIM, VEGFA, BIRC5, BCL2, BAX
46malignant mesothelioma21.0PCNA, VIM, VEGFA, BIRC5, BCL2, BAX
47myocardial infarction20.8PDCD1, VEGFA, BCL2, BAX, CDKN1A, CDKN2A
48esophageal carcinoma20.2PCNA, SERPINB5, VEGFA, MYC, BIRC5, BAX
49lung carcinoma20.1PCNA, SERPINB5, VHL, VEGFA, MYC, BIRC5
50thyroid cancer19.9PCNA, SERPINB5, VIM, VEGFA, MYC, BIRC5

Graphical network of the top 20 diseases related to tongue cancer:



Graphical network of diseases related to tongue cancer

Clinical Features for Tongue Cancer

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Drugs & Therapeutics for Tongue Cancer

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for tongue cancer

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Genetic Tests for Tongue Cancer

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Anatomical Context for Tongue Cancer

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22MalaCards
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MalaCards organs/tissues related to tongue cancer:

22
Lymph node, Salivary gland, Tonsil, T cells, Endothelial, Tongue

Phenotypes for genes affiliated with Tongue Cancer

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25MGI
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MGI Mouse Phenotypes related to tongue cancer:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.8CA9
2craniofacial phenotypeMP:000538210.2CSK, NOTCH1
3renal/urinary system phenotypeMP:00053678.9HIF1A, NOTCH1, CTNNB1, PTEN, CDKN1A, BAX
4hematopoietic system phenotypeMP:00053978.8EPOR, EPCAM, KLRK1, NOTCH1, HPSE, ENG
5behavior/neurological phenotypeMP:00053868.4SPP1, CTNNB1, PFDN5, PRLR, PRL, PTEN
6immune system phenotypeMP:00053878.3PTK2, TERT, TP53, FHIT, MMP8, VIM
7hearing/vestibular/ear phenotypeMP:00053778.3SOD1, NOTCH1, CTNNB1, FAS, CDKN1A, BAX
8limbs/digits/tail phenotypeMP:00053718.3PRLR, CTNNB1, PTK2, FAS, MMP9, CD44
9reproductive system phenotypeMP:00053898.2PRL, PFDN5, SPP1, PTK2, MMP9, CDH1
10normal phenotypeMP:00028738.1NOTCH1, NOTCH4, HIF1A, CSK, EPOR, TERT
11embryogenesis phenotypeMP:00053808.0CDK1, CDH2, BIRC5, MYC, VHL, VIM
12liver/biliary system phenotypeMP:00053707.9SLC10A2, SOD1, PRL, HIF1A, TP53, VEGFA
13pigmentation phenotypeMP:00011867.8NOTCH1, CTNNB1, PTEN, TP53, FAS, CDKN2A
14nervous system phenotypeMP:00036317.4NOTCH4, PFDN5, HIF1A, PRLR, PRL, CSK
15no phenotypic analysisMP:00030127.0TNKS, PTK2, CTNNB1, SLC2A1, EPOR, TP53
16integument phenotypeMP:00107716.9TP53, PTK2, CTNNB1, NOTCH1, PRLR, PRL
17mortality/agingMP:00107686.4EPOR, FHIT, CDH1, CDK1, CDH2, CDKN1A
18skeleton phenotypeMP:00053905.8TP53, TERT, PTEN, SPP1, CTNNB1, NOTCH1
19growth/size phenotypeMP:00053785.7NOTCH1, CTNNB1, SPP1, PTK2, PTEN, NOTCH4
20digestive/alimentary phenotypeMP:00053815.3CA9, TP53, TERT, PTEN, PTK2, CTNNB1
21vision/eye phenotypeMP:00053915.3TP53, PTEN, CTNNB1, NOTCH1, PFDN5, HIF1A
22tumorigenesisMP:00020064.7MYC, VHL, BCL2, FAS, FHIT, MMP9
23muscle phenotypeMP:00053694.6SOD1, CD44, CDKN2A, CDH2, CDKN1A, BAX
24cardiovascular system phenotypeMP:00053854.3PTK2, PTEN, TNKS, TP53, HPSE, SPP1
25cellular phenotypeMP:00053842.9TP53, BCL2, BIRC5, MYC, VEGFA, VHL
26homeostasis/metabolism phenotypeMP:00053762.3EPOR, EPCAM, SLC10A2, SLC2A1, SOD1, PRL

Publications for genes affiliated with Tongue Cancer

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35PubMed
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Articles related to tongue cancer:

(show all 45)
idTitleAuthorsYearAffiliating Genes
1Significance of tumor satellite variables in reflecti ng the epithelial-mesenchymal transition of tongue cancer. (21664858)Yang T.L.... Chang Y.L.2011CDH1, VIM
2Lentivirus-mediated gene silencing of beta-catenin in hibits growth of human tongue cancer cells. (21352379)Duan Y.... Fan M.2011CTNNB1
3Disruptive TP53 mutation is associated with aggressiv e disease characteristics in an orthotopic murine model of oral tongue cancer. (21903770)Sano D.... Myers J.N.2011TP53
4The prognostic role of phospho-Src family kinase anal ysis in tongue cancer. (19565264)Ben-Izhak O.... Nagler R.M.2010CSK
5Emodin, aloe-emodin and rhein inhibit migration and i nvasion in human tongue cancer SCC-4 cells through the inhibition of gene expre ssion of matrix metalloproteinase-9. (20372784)Chen Y.Y.... Chung J.G.2010MMP2, MMP9
6Identification of carbonic anhydrase 9 as a contribut or to pingyangmycin-induced drug resistance in human tongue cancer cells. (21040473)Zheng G.... He Z.2010CA9
7Tumor-host histopathologic variables, stromal myofibr oblasts and risk score, are significantly associated with recurrent disease in tongue cancer. (19804423)Vered M.... Taicher S.2010CDH1, MKI67
8Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer. (20127254)Jiang H.... Wu Y.2010PTK2
9Upregulation of CENP-H in tongue cancer correlates wi th poor prognosis and progression. (19500341)Liao W.T.... Li J.S.2009CENPH
10Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer. (19328339)Joo Y.H.... Sun D.I.2009VEGFA, NOTCH1, NOTCH4
11The prognostic value of hypoxia markers in T2-staged oral tongue cancer. (18620902)Roh J.L.... Kim S.Y.2009HIF1A, SLC2A1, CA9
12Signaling pathways for induction of platelet aggregat ion by SAS tongue cancer cells--a mechanism of hematogenous metastasis. (18811671)Chang M.C.... Jeng J.H.2009F3
13An essential role for N-cadherin and beta-catenin for progression in tongue squamous cell carcinoma and their effect on invasion and metastasis of Tca8113 tongue cancer cells. (19360298)Li S.... Zhang M.2009CTNNB1, CDH2
14Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. (18072267)Asakawa T.... Ikeda M.2008VHL
15Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer. (18253113)Korpi J.T.... Salo T.2008MMP8
16A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer. (18276095)Shimizu Y.... Yoshizaki T.2008MMP1, IL8
17The study of apoptosis induction effect of vitamin E succinate on Tca8113 human tongue cancer cells (18780489)Cao X.P.... Zhang S.T.2008FAS
18Clinical significance of osteopontin expression in T1 and T2 tongue cancers. (18228527)Chien C.Y.... Huang C.C.2008SPP1
19Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer. (17611661)Gonzalez-Moles M.A.... Bascones-Martinez A.2007CDKN1A, CD44, CDKN2A
20Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent mitochondrial pathway. (18210755)Lin Y.T.... Chung J.G.2007BAX
21Silencing of survivin gene enhances chemosensitivity of human tongue cancer cell line Tca8113 to cisplatin (17686279)Xu J.H.... Zhang L.T.2007BIRC5
22Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer. (18056444)Katou F.... Hashimoto K.2007PDCD1, KLRC1, CD69
23Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor (VEGF). (17174141)Cho J.H.... Kim H.K.2007TP53, SERPINB5
24Heparanase up-regulation in tongue cancer: tissue and saliva analysis. (17955520)Nagler R.... Ilan N.2007HPSE
25Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. (17207659)Yanamoto S.... Mizuno A.2007EPCAM
26Construction of antisense human tankyrase-1 RNA retroviral vector and its inhibition on tongue cancer cells (17565831)Ji Y.X.... Tao X.J.2007TNKS
27Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression. (16496371)Kim S.H.... Choi E.C.2006MMP2, MMP9
28High expression of CD105 as a prognostic predictor of early tongue cancer. (16826056)Chuang H.C.... Huang C.C.2006VEGFA, ENG
29Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer. (17141074)Keum K.C.... Kim G.E.2006TP53, PCNA
30Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes. (16737765)Jeng J.H.... Chang M.C.2006SOD1, CDKN1A, CDK1
31Effects of arsenic trioxideon the cell apoptosis and hTERT mRNA of human tongue cancer cells (16285558)Yao H.... Fan J.2005TERT
32Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases. (15536331)Nakanishi Y.... Hirohashi S.2004FXYD5
33P21WAF1/CIP1 protein and tongue cancer prognosis. (15510615)Gonzalez-Moles M.A.... Bascones A.2004CDKN1A
34Adhesion molecule CD44 expression in non-tumour epithelium adjacent to tongue cancer. (14747059)GonzA!lez-Moles M.A.... GonzA!lez-Moles S.2004CD44
35The experimental study on telomerase activity and expression of p53 and c-myc genes in tongue cancer (14513581)Fang Z.... Wang C.2003MYC
36Loss of PTEN expression as a prognostic marker for tongue cancer. (11735811)Lee J.I.... Mao L.2001PTEN
37Loss of Fhit expression is a predictor of poor outcome in tongue cancer. (11221865)Lee J.I.... Mao L.2001FHIT
38A study on tongue cancer cell labeling using bromodeoxyuridine (BrdU) incorporation in vitro (12539478)Li X.... Chen W.2001PCNA
39MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. (11567024)Fujioka Y.... Ariga H.2001MYC, PFDN5
40Prolactin as a local growth promoter in patients with locally advanced tongue cancer: GCRI experience. (10748449)Bhatavdekar J.M.... Ghosh N.2000PRLR, PRL
41Differential expression of cytokeratin after orthotopic implantation of newly established human tongue cancer cell lines of defined metastatic ability. (10751357)Morifuji M.... Ohishi M.2000KRT13
42SSCP pattern indicative for p53 mutation is related to advanced stage and high-grade of tongue cancer. (8776417)Atula S.... SyrjAonen S.1996BCL2
43Combination effects of gamma-interferon with pinyanmycin or psoralen on tongue cancer HSC3 cell line in vitro and in vivo. (7540529)Wu J.... Liu B.1995WIBG
44Circulating prolactin and tumoral prolactin receptors in men with tongue cancer: a preliminary study. (8181582)Patel D.D.... Balar D.B.1994PRLR
45Prolactin: its role in advanced tongue cancer. (7934062)Bhatavdekar J.M.... Balar D.B.1994PRL

Expression for genes affiliated with Tongue Cancer

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Pathways for genes affiliated with Tongue Cancer

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41Thomson Reuters, 10EMD Millipore, 3Cell Signaling Technology, 36QIAGEN, 38Reactome, 20KEGG, 34PharmGKB, 37R&D Systems
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Pathways related to tongue cancer according to GeneDecks:

(show top 50)    (show all 51)
idPathwayScoreTop Affiliating Genes
1Signal transduction_PTEN pathway4110.7PCNA
2Signal transduction PTEN pathway1010.5PTEN, CDKN1A, PCNA
3Adhesion310.5CDH2, CD44, EPCAM
4Apoptosis and survival Role of CDK5 in neuronal death and survival1010.4BCL2
5DNA damage ATM/ATR regulation of G1/S checkpoint1010.3MYC
6Akt Signaling3610.1EPOR, PTK2
7Cell adhesion_Cadherin-mediated cell adhesion4110.0CTNNB1, PTK2, CDH1, CDH2
8Cell adhesion Cadherin-mediated cell adhesion1010.0CTNNB1, PTK2, CDH1, CDH2
9Glioblastoma Multiforme369.9CDKN1A, TP53, PTEN
10Activation of Matrix Metalloproteinases389.8MMP9, MMP8, MMP2, MMP1
11EGF Pathway369.8CSK, CTNNB1, PTK2, CDH1, MYC
12Presenilin-Mediated Signaling369.8NOTCH4, NOTCH1, CTNNB1, CDH1, CDH2, BCL2
13Inhibition of Matrix Metalloproteinases369.7MMP9, MMP8, MMP2, MMP1
14ILK Signaling369.7EPOR, HIF1A, CTNNB1, PTK2, CDH1, CDH2
15Metalloproteases in connective tissue degradation109.6MMP9, MMP8, MMP2, MMP1, CDH1
16Cell adhesion_ECM remodeling419.4IL8, MMP9, MMP2, MMP1, CD44
17Cell adhesion ECM remodeling109.4IL8, MMP9, MMP2, MMP1, CD44
18Melanoma209.4PTEN, TP53, CDH1, CDKN2A, CDKN1A
19Celecoxib Pathway, Pharmacodynamics349.4CTNNB1, CA9, MMP9, CDKN1A, VEGFA
20UPA-UPAR Pathway369.3SPP1, PTK2, MMP9, MMP8, MMP2, MMP1
21Angiogenesis39.3HIF1A, NOTCH4, NOTCH1, CA9, ENG, MMP9
22Thyroid cancer209.3MYC, CDH1, TP53, CTNNB1
23Development_Prolactin receptor signaling419.2MYC, BCL2, PRLR, PRL
24Endometrial cancer209.2CTNNB1, PTEN, TP53, CDH1, MYC
25Transcription P53 signaling pathway109.2VEGFA, CDKN2A, TP53
26Apoptosis and survival_Role of CDK5 in neuronal death and survival419.2TP53, CDK1, BAX, BCL2
27DNA damage_ATM/ATR regulation of G1/S checkpoint419.2TP53, CDKN1A, MYC, PCNA
28Prostate cancer209.2CTNNB1, PTEN, TP53, CDKN1A, BCL2
29HIF1Alpha Pathway369.1SLC2A1, HIF1A, TP53, CDKN2A, VHL
30Apoptosis and Autophagy39.1FAS, BAX, BCL2, BIRC5, MYC, SERPINB5
31Signal transduction_AKT signaling419.1PTEN, TP53, CDKN1A, BAX, MYC, PCNA
32Pathogenesis of ALS369.0SOD1, TP53, BAX, BCL2
33Selected targets of p53109.0SLC2A1, TP53, CDK1, CDKN1A, BAX, BCL2
34Cell cycle209.0TP53, CDK1, CDKN2A, CDKN1A, MYC, PCNA
35Apoptosis Signaling Pathways379.0TP53, FAS, CDKN1A, BAX, BCL2, BIRC5
36Rho Family GTPases369.0EPOR, SPP1, PTK2, IL8, CDH1, CDH2
37p53 Signaling368.9HIF1A, PTEN, TP53, CDKN1A, BAX, BCL2
38Focal adhesion208.9CTNNB1, SPP1, PTK2, PTEN, BCL2, VEGFA
39p53 signaling pathway208.9PTEN, TP53, FAS, CDK1, CDKN2A, CDKN1A
40WNT Signaling368.8CTNNB1, TP53, CDH1, CDH2, BIRC5, MYC
41Transendothelial Migration of Leukocytes368.7CTNNB1, SPP1, PTK2, IL8, MMP9, MMP8
42Inhibition of Ribosome Biogenesis by p14(ARF)368.7MYC, CDKN2A, TP53
43Amyotrophic lateral sclerosis (ALS)208.6BCL2, BAX, TP53, SOD1
44Small cell lung cancer208.5PTK2, PTEN, TP53, FHIT, BCL2, MYC
45Transcription_P53 signaling pathway418.3CTNNB1, TP53, MMP2, CDKN2A, CDKN1A, BCL2
46Pancreatic Adenocarcinoma367.9EPOR, NOTCH1, TP53, MMP9, MMP8, MMP2
47Colorectal Cancer Metastasis367.9CTNNB1, TP53, MMP9, MMP2, MMP1, CDH1
48Bladder cancer207.3TP53, VEGFA, MYC, CDKN1A, CDKN2A, CDH1
49Molecular Mechanisms of Cancer367.3SPP1, CTNNB1, NOTCH1, NOTCH4, HIF1A, EPOR
50Pathways in cancer205.9HIF1A, SLC2A1, CTNNB1, PTK2, PTEN, VEGFA

Compounds for genes affiliated with Tongue Cancer

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Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 34PharmGKB, 18HMDB
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Compounds related to tongue cancer according to GeneDecks:

(show top 50)    (show all 273)
idCompoundScoreTop Affiliating Genes
1egcg32 10.4SOD1
2h2o232 10.4CSK, MMP8
3sp 60012532 42 10.6CSK, TP53, MMP1, CDKN1A
4rapamycin32 42 10.1CDK1, VEGFA, VHL, VIM, CA9, TERT
5tgf beta132 9.0CTNNB1, SPP1, PTK2, PTEN, ENG, FAS
6agar32 8.7EPOR, SLC2A1, HIF1A, CTNNB1, ENG, FHIT
7mg 13232 42 9.7CDKN2A, CDKN1A, BAX, BIRC5, MYC, PCNA
8troglitazone32 42 9 9 11.0SLC2A1, KRT13, SPP1, PTEN, IL8, MMP9
9depsipeptide32 8.0SERPINB5, MYC, TERT, TP53, FAS, MMP2
10doxorubicin32 34 9 9 10.8EPOR, HIF1A, CTNNB1, PTK2, PTEN, TERT
11oxygen32 18 8.7PTEN, TERT, HPSE, ENG, FAS, MMP8
12cysteine32 7.5PTK2, PTEN, TERT, ENG, MMP9, MMP8
13estrogen32 7.5MMP1, CDH1, CDH2, VHL, SERPINB5, PCNA
14celecoxib32 42 34 9 18 9 12.4PCNA, VEGFA, BIRC5, BCL2, HIF1A, CTNNB1
15progesterone32 42 9 18 9 11.3CSK, PRL, PRLR, CTNNB1, PTK2, PTEN
16gemcitabine32 34 9 9 10.3HIF1A, PTEN, TP53, HPSE, MMP2, CDKN1A
175-aza-2deoxycytidine32 7.2VIM, SERPINB5, PCNA, VHL, PTEN, TERT
18proline32 7.2EPOR, CSK, PRLR, HIF1A, KRT13, NOTCH1
19pdtc32 7.2SOD1, HIF1A, TP53, F3, IL8, MMP9
20docetaxel32 34 9 9 10.2PTK2, TP53, CDH1, CDK1, CDKN2A, CDKN1A
21thymidylate32 7.2TERT, PCNA, VIM, TP53, FAS, MKI67
22ly29400232 7.0EPOR, SLC2A1, NOTCH1, SPP1, PTK2, IL8
23phosphatidylinositol32 6.9KLRK1, VHL, MYC, BIRC5, BCL2, NOTCH1
24etoposide32 42 9 9 9.9FAS, MMP2, CDH1, CD44, CDK1, CDKN1A
25matrigel32 6.8VEGFA, VIM, SERPINB5, CDH2, CD44, CDH1
26n acetylcysteine32 6.8HIF1A, CTNNB1, PTK2, TERT, TP53, FHIT
27adriamycin32 6.7SOD1, VIM, MYC, BIRC5, BCL2, HIF1A
28lactate32 6.6MMP1, CDH1, CD44, BIRC5, VIM, PCNA
29testosterone32 9 18 9 9.4PRL, PRLR, HIF1A, CTNNB1, SPP1, PTK2
30pd 98,05932 6.4CDKN1A, BAX, BCL2, BIRC5, MYC, CD69
31retinoic acid32 42 18 8.3CDK1, CDKN2A, CDH2, CDKN1A, BAX, BIRC5
32oligonucleotide32 6.2ENG, FAS, MMP8, MMP1, CDKN2A, CDH2
33curcumin32 6.1MMP2, MMP1, CDH1, CDK1, CDKN1A, BAX
34resveratrol32 9 18 9 9.0MMP2, CDK1, CDKN1A, BAX, BCL2, BIRC5
355fluorouracil32 5.9PTEN, TERT, TP53, FAS, MKI67, MMP2
36alanine32 5.8PTEN, PCNA, VIM, HPSE, F3, MMP9
37sb 20358032 42 6.5BIRC5, VEGFA, VIM, BCL2, PTK2, TP53
38butyrate32 5.4SLC2A1, PRLR, HIF1A, CTNNB1, SPP1, PTK2
39actinomycin d32 5.4TP53, F3, FAS, IL8, MMP9, CD44
40tamoxifen32 34 9 9 8.3PTK2, VIM, SERPINB5, PCNA, VEGFA, MYC
41vegf32 5.2EPOR, SLC2A1, MMP8, MMP1, CDH1, CDK1
42paclitaxel32 34 9 9 8.2TP53, VIM, PCNA, VEGFA, MYC, BIRC5
43arsenite32 18 6.1MMP1, CDK1, CDKN2A, CDKN1A, BAX, BCL2
44dexamethasone32 42 34 9 9 9.1SLC10A2, SLC2A1, PRL, PRLR, HIF1A, NOTCH1
45tyrosine32 5.0EPOR, SLC2A1, CSK, PRLR, HIF1A, KLRC1
46cisplatin32 34 9 9 7.9CD44, CDK1, CDKN2A, CDKN1A, BAX, BCL2
47genistein32 9 18 9 7.3PRLR, HIF1A, NOTCH1, CTNNB1, SPP1, PTK2
48cycloheximide32 3.9SLC2A1, MMP1, CD44, CDK1, CDKN2A, CD69
49serine32 3.7F3, CDKN1A, BCL2, BIRC5, MYC, VHL
50paraffin32 3.1EPOR, EPCAM, SLC2A1, PRLR, HIF1A, KRT13

GO Terms for genes affiliated with Tongue Cancer

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12Gene Ontology
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Cellular components related to tongue cancer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:01634210.1CTNNB1, CDH1, CDH2
2PCNA-p21 complexGO:07055710.0PCNA, CDKN1A
3cell surfaceGO:0099869.1EPCAM, PRLR, NOTCH4, ENG, CDH1, CD44
4nucleoplasmGO:0056548.0PCNA, WIBG, HIF1A, NOTCH4, NOTCH1, TERT
5extracellular spaceGO:0056157.6SPP1, F3, ENG, IL8, MMP9, MMP8
6plasma membraneGO:0058866.9CTNNB1, NOTCH1, NOTCH4, KLRC1, PRLR, SOD1
7extracellular regionGO:0055766.8EPOR, SOD1, PRL, PRLR, NOTCH4, NOTCH1
8cytosolGO:0058295.9FAS, TP53, PTEN, PTK2, CTNNB1, NOTCH4
9nucleusGO:0056344.6MAU2, HPSE, TP53, PTEN, PTK2, CTNNB1
10cytoplasmGO:0057374.4F3, TP53, TERT, PTEN, PTK2, CTNNB1

Biological processes related to tongue cancer according to GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:03110010.1NOTCH1, MKI67, CDK1, CDKN1A
2response to cadmium ionGO:04668610.1CTNNB1, CDK1, PCNA
3cellular component disassembly involved in apoptotic processGO:00692110.0VIM, CDH1, PTK2, CTNNB1
4positive regulation of neuroblast proliferationGO:00205210.0HIF1A, NOTCH1, CTNNB1
5regulation of nitrogen utilizationGO:0068089.9BCL2, BAX
6positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8HIF1A, NOTCH1, VEGFA
7collagen catabolic processGO:0305749.8MMP9, MMP8, MMP2, MMP1
8regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.7HIF1A, CA9, VEGFA, VHL
9regulation of mitochondrial membrane potentialGO:0518819.7BCL2, BAX, SOD1
10extracellular matrix disassemblyGO:0226179.7ENG, MMP9, MMP8, MMP2, MMP1
11response to copper ionGO:0466889.7BCL2, CDK1, SOD1
12response to toxinGO:0096369.7FAS, CDH1, CDK1, CDKN1A, BAX, BCL2
13replicative senescenceGO:0903999.7TERT, TP53, CDKN2A, CDKN1A
14embryo implantationGO:0075669.7SOD1, PRLR, SPP1, MMP9
15cellular response to stressGO:0335549.7HIF1A, CA9, VEGFA, VHL
16activation of pro-apoptotic gene productsGO:0086339.6FAS, BAX, BCL2, MYC
17mitotic cell cycleGO:0002789.5CDK1, CDKN2A, CDKN1A, CENPH, BIRC5, PCNA
18apoptotic DNA fragmentationGO:0063099.5SOD1, CDKN2A, BAX, MYC
19extracellular matrix organizationGO:0301989.5PTK2, MMP9, MMP8, MMP2, MMP1, SERPINB5
20activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4F3, FAS, CDKN2A, BAX, MYC
21neuron apoptotic processGO:0514029.2TP53, FAS, BAX, BCL2
22cell agingGO:0075699.1SOD1, TP53, CDK1, BCL2
23anti-apoptosisGO:0069169.1VHL, SOD1, PRLR, TERT, F3, FAS
24release of cytochrome c from mitochondriaGO:0018369.0TP53, BAX, BCL2, MYC
25response to gamma radiationGO:0103329.0MYC, BCL2, BAX, TP53
26induction of apoptosis by intracellular signalsGO:0086299.0MYC, BCL2, BAX, CDKN1A, TP53
27angiogenesisGO:0015258.9HIF1A, PTK2, PTEN, IL8, MMP2, VEGFA
28cellular response to hypoxiaGO:0714568.9HIF1A, TP53, CA9, VEGFA, VHL
29positive regulation of cell proliferationGO:0082848.8VEGFA, MYC, BIRC5, PTEN, PTK2, NOTCH1
30negative regulation of cell proliferationGO:0082858.7CSK, CTNNB1, PTEN, TP53, IL8, CDKN2A
31response to hypoxiaGO:0016668.6HIF1A, ENG, FAS, MMP9, BCL2, VEGFA
32response to drugGO:0424938.4SOD1, CTNNB1, FAS, MMP9, CDH1, CDK1
33cell cycle arrestGO:0070508.3TP53, IL8, CDKN2A, CDKN1A, MYC
34positive regulation of transcription, DNA-dependentGO:0458938.3HIF1A, NOTCH4, NOTCH1, CTNNB1, TP53, CDH1
35positive regulation of apoptotic processGO:0430658.2SOD1, CTNNB1, TP53, FAS, MMP9, BAX
36negative regulation of apoptotic processGO:0430668.2PTK2, PTEN, TP53, CD44, CDKN1A, BCL2
37blood coagulationGO:0075968.1CSK, SOD1, PTK2, TP53, CAP1, F3
38apoptotic processGO:0069158.0FAS, TP53, PTEN, PTK2, CTNNB1, CDH1
39positive regulation of transcription from RNA polymerase II promoterGO:0459447.4HIF1A, NOTCH1, CTNNB1, TNKS, TP53, ENG

Molecular functions related to tongue cancer according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.8CDH2, CDH1, CTNNB1, CSK
2enzyme bindingGO:0198998.6HIF1A, NOTCH1, CTNNB1, PTEN, TP53, BIRC5
3protein kinase bindingGO:0199018.2HIF1A, PTK2, PTEN, TP53, CDKN2A, CDH2
4identical protein bindingGO:0428028.1EPOR, SLC2A1, TP53, FAS, BAX, BCL2
5transcription factor bindingGO:0081347.9HIF1A, CTNNB1, TP53, CDKN2A, BCL2, MYC
6protein heterodimerization activityGO:0469827.5HIF1A, NOTCH4, TP53, BAX, BCL2, BIRC5
7protein bindingGO:0055151.8EPOR, TERT, TNKS, TP53, HPSE, F3

Sources for Tongue Cancer

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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