MCID: TNG003
MIFTS: 49

Tongue Cancer malady

Cancer category

Summaries for Tongue Cancer

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Oral cancer or mouth cancer, a subtype of head and neck cancer, is any cancerous tissue growth located... more...

MalaCards: Tongue Cancer, also known as tongue carcinoma, is related to oral cancer and squamous cell carcinoma. An important gene associated with Tongue Cancer is PRLR (prolactin receptor), and among its related pathways are Angiogenesis and MicroRNAs in cancer. The compounds depsipeptide and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and liver, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Tongue Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

tongue cancer 8 43 10 45
tongue carcinoma 43 45 61
malignant neoplasm of tongue 8 61
malignant neoplasm of anterior two-thirds of tongue, part unspecified 8
malignant neoplasm of tip and/or lateral border of tongue 8
malignant neoplasm of anterior 2/3 of tongue unspecified 8
malignant neoplasm of tip and lateral border of tongue 8
malignant neoplasm of tongue, tip and lateral border 8
malignant tumor of anterior two-thirds of tongue 8
malignant neoplasm of ventral tongue surface nos 8
malignant neoplasm of junctional zone of tongue 8
malignant neoplasm of mobile part of tongue nos 8
malignant neoplasm of ventral surface of tongue 8
malignant neoplasm of dorsal surface of tongue 8
malignant neoplasm of fixed part of tongue nos 8
malignant neoplasm of other sites of tongue 8
tongue neoplasm malignant stage unspecified 8
malignant neoplasm of dorsum of tongue nos 8
malignant tumor of mobile part of tongue 8
malignant neoplasm of dorsal tongue nos 8
malignant neoplasm of border of tongue 8
malignant neoplasm of lingual tonsil 8
malignant neoplasm of base of tongue 8
malignant tumor of posterior tongue 8
malignant neoplasm of tongue, nos 8
malignant tumor of lingual tonsil 8
malignant tumor of base of tongue 8
malignant neoplasm of tongue nos 8
malignant tumor of tongue 8


Related Diseases for Tongue Cancer

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tongue Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer31.4TERT, KRT13, CDKN1A
2squamous cell carcinoma30.3SERPINB5, VHL, CA9, WIBG, BMI1, MT-CO2
3leukoplakia29.9KRT13
4tonsil cancer10.3
5tongue disease10.3
6vascular cancer10.3
7warthin tumor10.1
8bone marrow cancer10.1
9lung cancer10.0CDKN1A
10cervical cancer10.0CA9, CDKN1A, TERT
11endometriosis10.0PRLR, CD69
12myeloma10.0KLRK1, CDKN1A
13laryngeal carcinoma10.0SERPINB5, TERT
14sarcoma10.0SERPINB5, TERT, CA9
15endometrial carcinoma10.0TERT, CDKN1A, CA9
16colon cancer10.0SERPINB5, TERT, CDKN1A
17myelodysplastic syndromes10.0CD69, BMI1
18acute leukemia10.0TERT, BMI1
19osteosarcoma10.0MT-CO2, CDKN1A, TERT
20hepatitis b10.0TERT
21glioblastoma multiforme10.0TERT, CDKN1A, VHL, KLRK1
22nasopharynx carcinoma10.0KLRK1, CA9, KRT13, TERT
23hepatocellular carcinoma10.0KLRK1, PRLR, CDKN1A, KRT13, TERT, SERPINB5
24adenoma10.0VHL, PRLR, CDKN1A, KRT13, TERT, SERPINB5
25colorectal cancer10.0CA9, CDKN1A, FXYD5, TERT, SERPINB5
26bladder carcinoma10.0SERPINB5, TERT, CDKN1A, CA9
27breast cancer10.0SERPINB5, TERT, CDKN1A, PRLR, BMI1, CA9
28stomach cancer10.0VHL, CDKN1A, TERT, SERPINB5
29renal clear cell carcinoma10.0CA9, VHL
30melanoma10.0KLRK1, CA9, BMI1, CDKN1A, FXYD5, TERT
31rheumatoid arthritis10.0KLRK1, PRLR, CD69, TERT
32burkitt's lymphoma10.0KLRC1, VHL, BMI1, PRLR, CD69, CDKN1A
33cholesteatoma10.0KRT13
34adenocarcinoma10.0KLRK1, VHL, CA9, PRLR, CDKN1A, KRT13
35pancreatic cancer10.0CDKN1A, TERT, SERPINB5
36prostate cancer10.0BMI1, CDKN1A, TERT, SERPINB5
37peritonitis10.0CD69
38leukemia10.0TERT, CDKN1A, PRLR, BMI1, KLRK1
39meningioma10.0TERT, PRLR
40malignant glioma10.0TERT, CDKN1A, CA9, VHL, KLRK1
41arthritis10.0CD69
42non-small cell lung carcinoma10.0TERT, CDKN1A, CA9
43psoriasis10.0KRT13, CD69
44ovarian cancer10.0SERPINB5, TERT, CDKN1A, VHL
45dyskeratosis congenita10.0
46rothmund-thomson syndrome10.0
47hepatitis c10.0
48cardia cancer10.0
49gastric ulcer10.0
50vallecula cancer10.0

Graphical network of the top 20 diseases related to Tongue Cancer:



Diseases related to tongue cancer

Clinical Features for Tongue Cancer

Drugs & Therapeutics for Tongue Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tongue Cancer

Drug clinical trials:

Search ClinicalTrials for Tongue Cancer

Search NIH Clinical Center for Tongue Cancer

Search CenterWatch for Tongue Cancer

Genetic Tests for Tongue Cancer

Anatomical Context for Tongue Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Tongue Cancer:

33
Bone marrow, Lymph node, Liver, Lung, Salivary gland, Prostate, Tonsil, T cells, Endothelial, Tongue

Animal Models for Tongue Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tongue Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2KLRK1, TERT, CDKN1A, PRLR, BMI1, VHL
2MP:000538410.1TERT, PFDN5, CDKN1A, CD69, PRLR, BMI1
3MP:000537910.0CA9, BMI1, PRLR, CDKN1A, TERT

Publications for Tongue Cancer

Sources:
51PubMed
See all sources

Articles related to Tongue Cancer:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
Treatment of cT1N0M0 Tongue Cancer: Outcome and Prognostic Parameters. (24045188)
2014
2
Long-term results of brachytherapy in early mobile tongue cancer with 10-year minimal follow-up. (23267163)
2013
3
A novel tumor: Specimen index for assessing adequacy of resection in early stage oral tongue cancer. (24332395)
2013
4
Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion. (24204919)
2013
5
Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer. (22926477)
2012
6
Radiation induced myelopathy in a patient with tongue cancer: a case report. (22060135)
2012
7
Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer. (22052623)
2012
8
Enhancement of kallikrein-related peptidase 10 expression attenuates proliferation and invasiveness of human tongue cancer cells in vitro]. (23268413)
2012
9
Evaluation of microscopic disease in oral tongue cancer using whole-mount histopathologic techniques: implications for the management of head-and-neck cancers. (21300463)
2012
10
Surgical management of tongue cancer during pregnancy. (21889278)
2012
11
Human papillomavirus and survival in patients with base of tongue cancer. (20725995)
2011
12
The Hannover experience: surgical treatment of tongue cancer--a clinical retrospective evaluation over a 30 years period. (21600000)
2011
13
Tumor satellite in predicting occult nodal metastasis of tongue cancer. (21670477)
2011
14
Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue. (21990227)
2011
15
Pseudoaneurysm of the lingual artery after concurrent intra-arterial chemotherapy with radiotherapy for advanced tongue cancer. (20310040)
2011
16
The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. (21397550)
2011
17
Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II). (20637679)
2010
18
Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. (20504371)
2010
19
Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer. (19328339)
2009
20
Effect of induction chemotherapy on speech and swallowing function in patients with oral tongue cancer. (19107949)
2009
21
Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells. (19414420)
2009
22
Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. (19331169)
2009
23
Significant invasion depth of early oral tongue cancer originated from the lateral border to predict regional metastases and prognosis. (19231137)
2009
24
Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p. (18072267)
2008
25
Intraoral sonography-assisted resection of T1-2 tongue cancer for adequate deep resection. (19041507)
2008
26
Characterization of a familial small supernumerary marker chromosome in a patient with adult-onset tongue cancer. (18544921)
2008
27
Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. (18561315)
2008
28
Clinical significance of osteopontin expression in T1 and T2 tongue cancers. (18228527)
2008
29
Significance of tumour volume measurements in tongue cancer: a novel role in staging. (17635274)
2007
30
Etiology of oral cancer in the young patient: is tongue cancer becoming the other cancer in women? (18088875)
2007
31
Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. (17207659)
2007
32
Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer. (18056444)
2007
33
Higher distant failure in young age tongue cancer patients. (16529977)
2006
34
Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001. (16669472)
2006
35
Ablation of advanced tongue or base of tongue cancer and reconstruction with free flap: functional outcomes. (16455224)
2006
36
High-dose-rate interstitial brachytherapy for mobile tongue cancer: influence of the non-irradiated period. (17094424)
2006
37
Intraoral sonographic features of tongue cancer after radical radiotherapy. (15544902)
2004
38
P21WAF1/CIP1 protein and tongue cancer prognosis. (15510615)
2004
39
Analysis of treatment results for oral tongue cancer. (12150512)
2002
40
Loss of Fhit expression is a predictor of poor outcome in tongue cancer. (11221865)
2001
41
A study on tongue cancer cell labeling using bromodeoxyuridine (BrdU) incorporation in vitro]. (12539478)
2001
42
Tongue cancer as a complication of dyskeratosis congenita in a woman. (10609487)
1999
43
The quality of life of patients treated for tongue cancer. (9484951)
1998
44
Tumor angiogenesis as a prognostic factor in early oral tongue cancer. (8703391)
1996
45
Establishment and characterization of a human tongue cancer xenograft line in nude mice. (8935069)
1994
46
Radiotherapy with or without neck dissection treatment of choice for base of tongue cancer. (7803217)
1994
47
Circulating prolactin and tumoral prolactin receptors in men with tongue cancer: a preliminary study. (8181582)
1994
48
Clinical examination, CT and US in tongue cancer staging. (3069463)
1988
49
Hypercalcemia and head and neck cancer. Bony metastases from tongue cancer. (697640)
1978
50
Tongue cancer. (4702628)
1973

Genetic Variations for Tongue Cancer

Expression for genes affiliated with Tongue Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tongue Cancer

Search GEO for disease gene expression data for Tongue Cancer.

Pathways for genes affiliated with Tongue Cancer

Sources:
4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Tongue Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3SERPINB5, CA9, VHL
210.3SERPINB5, CDKN1A, MIR200B, MIR15B, BMI1

Compounds for genes affiliated with Tongue Cancer

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank
See all sources

Compounds related to Tongue Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1depsipeptide4510.5SERPINB5
25-aza-2deoxycytidine4510.5SERPINB5, TERT, CDKN1A, CA9, VHL
3paraffin4510.4CA9, PRLR, CDKN1A, KRT13, TERT, SERPINB5
4oxygen45 2411.3KLRK1, VHL, CA9, MT-CO2, CD69, CDKN1A
5estrogen4510.3VHL, CA9, BMI1, PRLR, CDKN1A, TERT
6tamoxifen45 50 29 1113.3CA9, PRLR, CDKN1A, SERPINB5
7rapamycin4510.2VHL, CA9, CDKN1A, TERT
8tyrosine4510.2VHL, CA9, PRLR, CD69, CDKN1A, TERT
9ly2940024510.0TERT, CDKN1A, CD69, VHL

GO Terms for genes affiliated with Tongue Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Tongue Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1morphogenesis of an epitheliumGO:00200910.4SERPINB5, CA9

Products for genes affiliated with Tongue Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tongue Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet