Tongue Squamous Cell Carcinoma malady

Rare diseases, Skin diseases, Cancer diseases categories

Aliases & Classifications for Tongue Squamous Cell Carcinoma

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Aliases & Descriptions for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 30 8
Squamous Cell Carcinoma 8 42 10 61
Epidermoid Carcinoma 8 42
Squamous Cell Cancer 8 44
Squamous Cell Carcinoma - Category 61
Squamous Cell Carcinoma of Tongue 61
Malignant Squamous Cell Neoplasm 61
Squamous Cell Carcinoma of Skin 61
Malignant Squamous Cell Tumor 8
Squamous Cell Carcinoma Nos 8
Squamous Cell Skin Cancer 42
Squamous Cell Epithelioma 8
Carcinoma, Squamous Cell 42
Squamous-Cell Carcinoma 8
Carcinoma Squamous Cell 44
Squamous Carcinoma 8


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Disease Ontology8 DOID:0050865, DOID:1749
MeSH33 D002294
NCIt39 C2929

Summaries for Tongue Squamous Cell Carcinoma

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NIH Rare Diseases:42 Squamous cell carcinoma (scc) is the second most common skin cancer. scc most often affects individuals who are exposed to large amounts of sunlight. it is typically characterized by a red papule or plaque with a scaly or crusted surface; it may be suspected whenever a small, firm reddish-colored skin lesion, growth or bump appears on the skin, but it may also be a flat growth with a curly and crusted surface. most often these growths are located on the face, ears, neck, hands and/or arms, but they may occur on the lips, mouth, tongue, genitalia or other area. the most common causes of scc are radiation from the sun and arsenic exposure. with appropriate treatment, it is usually curable. last updated: 6/22/2011

MalaCards based summary: Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma, is related to hepatocellular carcinoma and oral squamous cell carcinoma. An important gene associated with Tongue Squamous Cell Carcinoma is DND1 (DND microRNA-mediated repression inhibitor 1), and among its related pathways is miRNAs involved in DDR. Affiliated tissues include the squamous cells of the tongue, tongue and pancreas.

Disease Ontology:8 A tongue cancer that is located in the squamous cells of the tongue.

Related Diseases for Tongue Squamous Cell Carcinoma

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Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 598)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma30.3CDC6, TWIST1, EBAG9
2oral squamous cell carcinoma11.7
5laryngeal squamous cell carcinoma11.5
6cervical squamous cell carcinoma11.3
7lung squamous cell carcinoma11.2
9basaloid squamous cell carcinoma11.2
14actinic keratosis11.0
15cystic teratoma11.0
16anal squamous cell carcinoma11.0
17epidermolysis bullosa11.0
18basal cell carcinoma11.0
19skin squamous cell carcinoma10.9
21lichen sclerosus10.9
22oral leukoplakia10.9
23adenoid squamous cell carcinoma10.9
25lupus erythematosus10.9
26recessive dystrophic epidermolysis bullosa10.9
27lung cancer10.8
30discoid lupus erythematosus10.8
32lichen planus10.8
33verrucous carcinoma10.8
34squamous cell carcinoma, head and neck10.8
36inverted papilloma10.8
37cervical intraepithelial neoplasia10.8
38epidermodysplasia verruciformis10.8
39maxillary sinus squamous cell carcinoma10.8
40vulvar intraepithelial neoplasia10.8
42keratinizing squamous cell carcinoma10.8
43bladder squamous cell carcinoma10.7
44esophageal cancer10.7
46hidradenitis suppurativa10.7
47oral submucous fibrosis10.7
48small cell carcinoma10.7
49esophagus squamous cell carcinoma10.7

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:

Diseases related to tongue squamous cell carcinoma

Symptoms for Tongue Squamous Cell Carcinoma

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Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
Erbitux13 38 CETUXIMAB Imclone, Bristol-Myers Squibb Approved February 2004
FDA Label: Erbitux
Malady that Drug Treats: Colorectal Cancer
Indications and Usage:13 Erbitux® is an epidermal growth factor receptor (EGFR) antagonist indicated; for treatment of:; Head and Neck Cancer; Locally or regionally advanced squamous cell carcinoma of the head; and neck in combination with radiation therapy. (1.1, 14.1); Recurrent locoregional disease or metastatic squamous cell carcinoma; of the head and neck in combination with platinum-based therapy with; 5-FU. (1.1, 14.1); Recurrent or metastatic squamous cell carcinoma of the head and neck; progressing after platinum-based therapy. (1.1, 14.1); Colorectal Cancer; K-Ras wild-type, EGFR-expressing, metastatic colorectal cancer as; determined by FDA-approved tests; in combination with FOLFIRI for first-line treatment,; in combination with irinotecan in patients who are refractory to; irinotecan-based chemotherapy,; as a single agent in patients who have failed oxaliplatin- and; irinotecan-based chemotherapy or who are intolerant to irinotecan.; (1.2, 5.7, 12.1, 14.2); Limitation of Use: Erbitux is not indicated for treatment of Ras-mutant; colorectal cancer. (5.7, 14.2)
DrugBank Targets:11 1. Epidermal growth factor receptor; 2. Low affinity immunoglobulin gamma Fc region receptor III-B; 3. Complement C1r subcomponent; 4. Complement C1q subcomponent subunit A; 5. Complement C1q subcomponent subunit B; 6. Complement C1q subcomponent subunit C; 7. Low affinity immunoglobulin gamma Fc region receptor III-A; 8. Complement C1s subcomponent; 9. High affinity immunoglobulin gamma Fc receptor I; 10. Low affinity immunoglobulin gamma Fc region receptor II-a; 11. Low affinity immunoglobulin gamma Fc region receptor II-b; 12. Low affinity immunoglobulin gamma Fc region receptor II-c
Mechanism of Action:13 
Target: binding of epidermal growth factor (EGF) and other ligands to epidermal growth factor receptor (EGFR, HER1, c-ErbB-1)
Action: inhibitor
FDA: The epidermal growth factor receptor (EGFR, HER1, c-ErbB-1) is a transmembrane; glycoprotein that is a member of a subfamily of type I receptor tyrosine kinases including EGFR,; HER2, HER3, and HER4. The EGFR is constitutively expressed in many normal epithelial; tissues, including the skin and hair follicle. Expression of EGFR is also detected in many human; cancers including those of the head and neck, colon, and rectum. ; ; ; Cetuximab binds specifically to the EGFR on both normal and tumor cells, and competitively; inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming; growth factor-alpha. In vitro assays and in vivo animal studies have shown that binding of; cetuximab to the EGFR blocks phosphorylation and activation of receptor-associated kinases,; resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix; metalloproteinase and vascular endothelial growth factor production. Signal transduction through; the EGFR results in activation of wild-type Ras proteins, but in cells with activating Ras somatic; mutations, the resulting mutant Ras proteins are continuously active regardless of EGFR; regulation.; In vitro, cetuximab can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain; human tumor types. In vitro assays and in vivo animal studies have shown that cetuximab; inhibits the growth and survival of tumor cells that express the EGFR. No anti-tumor effects of; cetuximab were observed in human tumor xenografts lacking EGFR expression. The addition of; cetuximab to radiation therapy or irinotecan in human tumor xenograft models in mice resulted; in an increase in anti-tumor effects compared to radiation therapy or chemotherapy alone.
Taxotere13 38 DOCETAXEL Rhone Poulenc Rorer Approved May 1996
FDA Label: Taxotere
Malady that Drug Treats: breast cancer
Indications and Usage:13 TAXOTERE is a microtubule inhibitor indicated for:; Breast Cancer (BC): single agent for locally advanced or metastatic BC; after chemotherapy failure; and with doxorubicin and; cyclophosphamide as adjuvant treatment of operable node-positive BC; (1.1); Non-Small Cell Lung Cancer (NSCLC): single agent for locally; ; advanced or metastatic NSCLC after platinum therapy failure; and; ; with cisplatin for unresectable, locally advanced or metastatic; untreated NSCLC (1.2); ; Hormone Refractory Prostate Cancer (HRPC): with prednisone in; androgen independent (hormone refractory) metastatic prostate cancer; (1.3); Gastric Adenocarcinoma (GC): with cisplatin and fluorouracil for; untreated, advanced GC, including the gastroesophageal junction (1.4); Squamous Cell Carcinoma of the Head and Neck Cancer (SCCHN):; with cisplatin and fluorouracil for induction treatment of locally; advanced SCCHN (1.5)
DrugBank Targets:11 1. Tubulin beta-1 chain; 2. Apoptosis regulator Bcl-2; 3. Microtubule-associated protein 2; 4. Microtubule-associated protein 4; 5. Microtubule-associated protein tau; 6. Nuclear receptor subfamily 1 group I member 2
Mechanism of Action:13 
Target: free tubulin
Action: promoter of assembly
FDA: Docetaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells that is; essential for mitotic and interphase cellular functions. Docetaxel binds to free tubulin and promotes the; assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly. This; leads to the production of microtubule bundles without normal function and to the stabilization of; microtubules, which results in the inhibition of mitosis in cells. Docetaxel s binding to microtubules; does not alter the number of protofilaments in the bound microtubules, a feature which differs from most; spindle poisons currently in clinical use.

Drug clinical trials:

Search ClinicalTrials for Tongue Squamous Cell Carcinoma

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Genetic Tests for Tongue Squamous Cell Carcinoma

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Anatomical Context for Tongue Squamous Cell Carcinoma

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MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

Tongue, Pancreas, Skin, Skeletal muscle, Thyroid, Endothelial, Lymph node, T cells, Bone marrow, Bone, Placenta, B cells, Smooth muscle, Monocytes

FMA organs/tissues related to Tongue Squamous Cell Carcinoma:

The squamous cells of the tongue

Animal Models for Tongue Squamous Cell Carcinoma or affiliated genes

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Publications for Tongue Squamous Cell Carcinoma

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Articles related to Tongue Squamous Cell Carcinoma:

(show top 50)    (show all 148)
FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma. (25573594)
SOD2 is a C-myc target gene that promotes the migration and invasion of tongue squamous cell carcinoma involving cancer stem-like cells. (25578561)
Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma. (25762643)
Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. (25834400)
Bmi1 drives stem-like properties and is associated with migration, invasion, and poor prognosis in tongue squamous cell carcinoma. (25552924)
Effect of HIF-1I+ on biological activation of human tongue squamous cell carcinoma SCC-15 cells in vitro. (25816356)
Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113. (25333745)
miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. (25843291)
Silencing Dicer expression enhances cellular proliferative and invasive capacities in human tongue squamous cell carcinoma. (24317682)
Apoptosis of human tongue squamous cell carcinoma cell (CAL-27) induced by Lactobacillus sp. A-2 metabolites. (25141199)
HIF-1I+ regulated tongue squamous cell carcinoma cell growth via regulating VEGF expression in a xenograft model. (25405167)
TP53 and CDKN2a mutations in never-smoker oral tongue squamous cell carcinoma. (24431303)
The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. (25169079)
Regulatory T-cell infiltration in tongue squamous cell carcinoma. (24921153)
Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes. (25685059)
Unexpected development of tongue squamous cell carcinoma after sclerotherapy for the venous malformation: a unique case report and literature review. (24188408)
Prognostic implications of micoRNA miR-195 expression in human tongue squamous cell carcinoma. (23451060)
Quality of life in patients younger than 40 years treated for anterior tongue squamous cell carcinoma. (24220465)
MiR-25-3p attenuates the proliferation of tongue squamous cell carcinoma cell line Tca8113. (23827155)
Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy. (21913013)
The expression and significance of MRP1, LRP, TOPOIII^, and BCL2 in tongue squamous cell carcinoma. (21793937)
Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. (22580338)
Dysregulated CC receptor/ligand in monocytes/macrophages from tongue squamous cell carcinoma patients is partially rectified by interferon I+-2b. (22085486)
Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. (22153618)
Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma. (21167768)
RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study. (21804460)
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. (20816961)
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma. (19775228)
MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines. (20219416)
EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma. (19332367)
Prognostic significance of erythropoietin and erythropoietin receptor in tongue squamous cell carcinoma. (19559511)
Expression of the FAM5C in tongue squamous cell carcinoma. (19787213)
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma. (19497117)
Expression and clinical significance of SPARC in clinical stage II tongue squamous cell carcinoma. (19448421)
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. (19487542)
nm23 protein expression in metastatic and non-metastatic tongue squamous cell carcinoma. (18661008)
Effect of using RNA interference to alter iNOS gene expression on the proliferation of tongue squamous cell carcinoma cell line Tca8113. (18406501)
Expressions and clinical significance of urokinase-type plasminogen activator (uPA) and uPA receptor (uPAR) in tongue squamous cell carcinoma]. (16525618)
Activation of ERK1/2 and cyclin D1 expression in oral tongue squamous cell carcinomas: relationship between clinicopathological appearances and cell proliferation. (16483832)
Prognostic value of cell motility activation factors in patients with tongue squamous cell carcinoma. (16867875)
In vitro gene silencing by siRNA of cyclin D1 on tongue squamous cell carcinoma cell line resistant to cisplatin]. (17331354)
Expression of cyclooxygenase-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma]. (16552960)
Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113)]. (16078458)
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence. (15955662)
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics. (14730689)
Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma]. (15017692)
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. (15240540)
Prognostic value of Bak expression in oral tongue squamous cell carcinomas. (12579274)
Establishment and biological characteristics of cisplatin resistant cell line from human tongue squamous cell carcinoma Tca8113]. (14994074)
Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma. (10091782)

Variations for Tongue Squamous Cell Carcinoma

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Cosmic variations for Tongue Squamous Cell Carcinoma:

6 (show all 231)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
144870TP53skin,face,carcinoma,squamous cell carcinoma3
210656TP53skin,face,carcinoma,squamous cell carcinoma3
3133679TP53skin,face,carcinoma,squamous cell carcinoma3
443585TP53skin,ear,carcinoma,squamous cell carcinoma3
5143788TP53skin,ear,carcinoma,squamous cell carcinoma3
643588TP53skin,face,carcinoma,squamous cell carcinoma3
7143793TP53skin,hand,carcinoma,squamous cell carcinoma3
810988TP53skin,face,carcinoma,squamous cell carcinoma3
9143792TP53skin,arm,carcinoma,squamous cell carcinoma3
10330674TP53skin,arm,carcinoma,squamous cell carcinoma3
1111081TP53skin,face,carcinoma,squamous cell carcinoma3
12142995TP53skin,ear,carcinoma,squamous cell carcinoma3
1310726TP53skin,ear,carcinoma,squamous cell carcinoma3
1487196TP53skin,face,carcinoma,squamous cell carcinoma3
15143796TP53skin,hand,carcinoma,squamous cell carcinoma3
16144150TP53skin,ear,carcinoma,squamous cell carcinoma3
1710939TP53skin,face,carcinoma,squamous cell carcinoma3
1843582TP53skin,face,carcinoma,squamous cell carcinoma3
1943665TP53skin,face,carcinoma,squamous cell carcinoma3
2045445TP53skin,face,carcinoma,squamous cell carcinoma3
2110768TP53skin,face,carcinoma,squamous cell carcinoma3
2245799TP53skin,face,carcinoma,squamous cell carcinoma3
23143790TP53skin,face,carcinoma,squamous cell carcinoma3
246545TP53skin,ear,carcinoma,squamous cell carcinoma3
2544225TP53skin,arm,carcinoma,squamous cell carcinoma3
26137877ANK2skin,face,carcinoma,squamous cell carcinoma3
27140491ANK2skin,ear,carcinoma,squamous cell carcinoma3
28139535ANK2skin,face,carcinoma,squamous cell carcinoma3
29139538ANK2skin,face,carcinoma,squamous cell carcinoma3
30139536ANK2skin,face,carcinoma,squamous cell carcinoma3
31498HRASskin,arm,carcinoma,squamous cell carcinoma3
32503HRASskin,face,carcinoma,squamous cell carcinoma3
33496HRASskin,arm,carcinoma,squamous cell carcinoma3
34483HRASskin,ear,carcinoma,squamous cell carcinoma3
35138224NRASskin,face,carcinoma,squamous cell carcinoma3
36564NRASskin,face,carcinoma,squamous cell carcinoma3
37585NRASskin,face,carcinoma,squamous cell carcinoma3
38574NRASskin,face,carcinoma,squamous cell carcinoma3
39138764ANK3skin,face,carcinoma,squamous cell carcinoma3
40139834ANK3skin,face,carcinoma,squamous cell carcinoma3
41139833ANK3skin,face,carcinoma,squamous cell carcinoma3
42516KRASskin,arm,carcinoma,squamous cell carcinoma3
43521KRASskin,hand,carcinoma,squamous cell carcinoma3
44520KRASskin,face,carcinoma,squamous cell carcinoma3
45137928ROS1skin,face,carcinoma,squamous cell carcinoma3
46139666ROS1skin,face,carcinoma,squamous cell carcinoma3
47138342ERBB4skin,face,carcinoma,squamous cell carcinoma3
48137375ERBB4skin,hand,carcinoma,squamous cell carcinoma3
49137939AUTS2skin,face,carcinoma,squamous cell carcinoma3
50139706AUTS2skin,face,carcinoma,squamous cell carcinoma3
5113963CDKN2Askin,hand,carcinoma,squamous cell carcinoma3
5253077CDKN2Askin,ear,carcinoma,squamous cell carcinoma3
5343063PIK3CGskin,face,carcinoma,squamous cell carcinoma3
54139727PIK3CGskin,face,carcinoma,squamous cell carcinoma3
55140813CDH19skin,ear,carcinoma,squamous cell carcinoma3
56140181CDH19skin,face,carcinoma,squamous cell carcinoma3
5729329PIK3CAskin,arm,carcinoma,squamous cell carcinoma3
5829328PIK3CAskin,face,carcinoma,squamous cell carcinoma3
59138150CDKL5skin,face,carcinoma,squamous cell carcinoma3
60138151CDKL5skin,face,carcinoma,squamous cell carcinoma3
61138649CTTNBP2skin,face,carcinoma,squamous cell carcinoma3
62139731CTTNBP2skin,face,carcinoma,squamous cell carcinoma3
63140479PPARGC1Askin,ear,carcinoma,squamous cell carcinoma3
64139513PPARGC1Askin,face,carcinoma,squamous cell carcinoma3
65140710FLT3skin,ear,carcinoma,squamous cell carcinoma3
66139987FLT3skin,face,carcinoma,squamous cell carcinoma3
67138721PTCH1skin,face,carcinoma,squamous cell carcinoma3
6817489PTCH1skin,face,carcinoma,squamous cell carcinoma3
69139902FADS2skin,face,carcinoma,squamous cell carcinoma3
70139901FADS2skin,face,carcinoma,squamous cell carcinoma3
71137925EPHA7skin,face,carcinoma,squamous cell carcinoma3
72140574GRM1skin,ear,carcinoma,squamous cell carcinoma3
73140341GNB1skin,ear,carcinoma,squamous cell carcinoma3
74138389FBXO40skin,face,carcinoma,squamous cell carcinoma3
75139146GSK3Askin,face,carcinoma,squamous cell carcinoma3
76138011FGF23skin,face,carcinoma,squamous cell carcinoma3
77140591EXOC4skin,ear,carcinoma,squamous cell carcinoma3
78140313FRMPD4skin,face,carcinoma,squamous cell carcinoma3
79138282FHskin,face,carcinoma,squamous cell carcinoma3
8035897FGFR3skin,face,carcinoma,squamous cell carcinoma3
81138049FSCBskin,face,carcinoma,squamous cell carcinoma3
82138619FZD9skin,face,carcinoma,squamous cell carcinoma3
83138397HPS3skin,face,carcinoma,squamous cell carcinoma3
84137940LIMK1skin,face,carcinoma,squamous cell carcinoma3
85137868LIMCH1skin,face,carcinoma,squamous cell carcinoma3
86138268KIF21Bskin,face,carcinoma,squamous cell carcinoma3
87137528KIAA1958skin,hand,carcinoma,squamous cell carcinoma3
88139288LRP8skin,face,carcinoma,squamous cell carcinoma3
89138060LTKskin,face,carcinoma,squamous cell carcinoma3
90139954LRRK2skin,face,carcinoma,squamous cell carcinoma3
91138433KDRskin,face,carcinoma,squamous cell carcinoma3
92139638ITPR3skin,face,carcinoma,squamous cell carcinoma3
93139862HSPA12Askin,face,carcinoma,squamous cell carcinoma3
94138382EPHA3skin,face,carcinoma,squamous cell carcinoma3
95139632HIST1H2AEskin,face,carcinoma,squamous cell carcinoma3
96140590IMPDH1skin,ear,carcinoma,squamous cell carcinoma3
97138058INO80skin,face,carcinoma,squamous cell carcinoma3
98138882ITGB7skin,face,carcinoma,squamous cell carcinoma3
99137413INPP4Bskin,hand,carcinoma,squamous cell carcinoma3
100140070HCN4skin,face,carcinoma,squamous cell carcinoma3
101140810DSG1skin,ear,carcinoma,squamous cell carcinoma3
102138647ASZ1skin,face,carcinoma,squamous cell carcinoma3
103138729ASTN2skin,face,carcinoma,squamous cell carcinoma3
104137330ASTN1skin,hand,carcinoma,squamous cell carcinoma3
105138824ASRGL1skin,face,carcinoma,squamous cell carcinoma3
10641596ATMskin,face,carcinoma,squamous cell carcinoma3
107140109ATP2A3skin,face,carcinoma,squamous cell carcinoma3
108139916CABP4skin,face,carcinoma,squamous cell carcinoma3
109140332BTKskin,face,carcinoma,squamous cell carcinoma3
110137863ATRskin,face,carcinoma,squamous cell carcinoma3
111138354ARL8Bskin,face,carcinoma,squamous cell carcinoma3
112139742ARHGEF5skin,face,carcinoma,squamous cell carcinoma3
113140644AGAP7skin,ear,carcinoma,squamous cell carcinoma3
114139354ADORA1skin,face,carcinoma,squamous cell carcinoma3
115140782ACAP1skin,ear,carcinoma,squamous cell carcinoma3
116138028ACAD10skin,face,carcinoma,squamous cell carcinoma3
117138291ALKskin,face,carcinoma,squamous cell carcinoma3
118139849ANKRD1skin,face,carcinoma,squamous cell carcinoma3
119139588APCskin,face,carcinoma,squamous cell carcinoma3
120140167ANKRD29skin,face,carcinoma,squamous cell carcinoma3
121143523ANKRD13Bskin,face,carcinoma,squamous cell carcinoma3
122140164ANKRD12skin,face,carcinoma,squamous cell carcinoma3
123138105CASKIN2skin,face,carcinoma,squamous cell carcinoma3
124138565CDC5Lskin,face,carcinoma,squamous cell carcinoma3
125137963DNAJA1skin,face,carcinoma,squamous cell carcinoma3
126139086DLGAP1skin,face,carcinoma,squamous cell carcinoma3
127138655DGKIskin,face,carcinoma,squamous cell carcinoma3
128140464DNAJB8skin,ear,carcinoma,squamous cell carcinoma3
129137753MAGEH1skin,hand,carcinoma,squamous cell carcinoma3
130139231EP300skin,face,carcinoma,squamous cell carcinoma3
131140123ELAC2skin,face,carcinoma,squamous cell carcinoma3
13249040EGFRskin,face,carcinoma,squamous cell carcinoma3
133140697DUSP6skin,ear,carcinoma,squamous cell carcinoma3
134140390DDR2skin,ear,carcinoma,squamous cell carcinoma3
135138502CDO1skin,face,carcinoma,squamous cell carcinoma3
136139572CDH6skin,face,carcinoma,squamous cell carcinoma3
137139569CDH18skin,face,carcinoma,squamous cell carcinoma3
138140021CEBPEskin,face,carcinoma,squamous cell carcinoma3
139137980CELF2skin,face,carcinoma,squamous cell carcinoma3
140139635DDR1skin,face,carcinoma,squamous cell carcinoma3
141137386CNTN3skin,hand,carcinoma,squamous cell carcinoma3
142138312CNNM3skin,face,carcinoma,squamous cell carcinoma3
143139586CHD1skin,face,carcinoma,squamous cell carcinoma3
144139981EP400skin,face,carcinoma,squamous cell carcinoma3
145138899MED13Lskin,face,carcinoma,squamous cell carcinoma3
146139392SLC9A2skin,face,carcinoma,squamous cell carcinoma3
147140296SMARCB1skin,face,carcinoma,squamous cell carcinoma3
148137424SKIV2L2skin,hand,carcinoma,squamous cell carcinoma3
149140675SIK3skin,ear,carcinoma,squamous cell carcinoma3
150137856SFMBT1skin,face,carcinoma,squamous cell carcinoma3
151137749SMSskin,hand,carcinoma,squamous cell carcinoma3
152138849SORL1skin,face,carcinoma,squamous cell carcinoma3
153139248TBX22skin,face,carcinoma,squamous cell carcinoma3
154138901TAOK3skin,face,carcinoma,squamous cell carcinoma3
155139009SRCAPskin,face,carcinoma,squamous cell carcinoma3
156139093SETBP1skin,face,carcinoma,squamous cell carcinoma3
157140273SALL4skin,face,carcinoma,squamous cell carcinoma3
158139573RAI14skin,face,carcinoma,squamous cell carcinoma3
159139284RAD54Lskin,face,carcinoma,squamous cell carcinoma3
160139480RAB43skin,face,carcinoma,squamous cell carcinoma3
161138095RAB34skin,face,carcinoma,squamous cell carcinoma3
162137791RALGPS2skin,face,carcinoma,squamous cell carcinoma3
163139018RANBP10skin,face,carcinoma,squamous cell carcinoma3
164140362ROR1skin,ear,carcinoma,squamous cell carcinoma3
165138048RNF31skin,face,carcinoma,squamous cell carcinoma3
166140860RBL1skin,ear,carcinoma,squamous cell carcinoma3
167139583RASGRF2skin,face,carcinoma,squamous cell carcinoma3
168140176TCF4skin,face,carcinoma,squamous cell carcinoma3
169140331TEX11skin,face,carcinoma,squamous cell carcinoma3
170139559VEGFCskin,face,carcinoma,squamous cell carcinoma3
171138893USP44skin,face,carcinoma,squamous cell carcinoma3
172138845USP28skin,face,carcinoma,squamous cell carcinoma3
173137981UPF2skin,face,carcinoma,squamous cell carcinoma3
174138343VIL1skin,face,carcinoma,squamous cell carcinoma3
175138968VPS13Cskin,face,carcinoma,squamous cell carcinoma3
176140327WNK3skin,face,carcinoma,squamous cell carcinoma3
177138854WNK1skin,face,carcinoma,squamous cell carcinoma3
178137316WDR63skin,hand,carcinoma,squamous cell carcinoma3
179139244VSIG4skin,face,carcinoma,squamous cell carcinoma3
180140346UBR4skin,ear,carcinoma,squamous cell carcinoma3
181139036UBE2G1skin,face,carcinoma,squamous cell carcinoma3
182138199TMEM59skin,face,carcinoma,squamous cell carcinoma3
183138710TLN1skin,face,carcinoma,squamous cell carcinoma3
184140638THNSL1skin,ear,carcinoma,squamous cell carcinoma3
185138043TFDP1skin,face,carcinoma,squamous cell carcinoma3
186139802TRIM32skin,face,carcinoma,squamous cell carcinoma3
187139204TPTEskin,face,carcinoma,squamous cell carcinoma3
188139501TP63skin,face,carcinoma,squamous cell carcinoma3
189139190PTPRTskin,face,carcinoma,squamous cell carcinoma3
190140822PTPRSskin,ear,carcinoma,squamous cell carcinoma3
191138812NUP160skin,face,carcinoma,squamous cell carcinoma3
192138241NTRK1skin,face,carcinoma,squamous cell carcinoma3
193138691NSMCE2skin,face,carcinoma,squamous cell carcinoma3
194140722NPAS3skin,ear,carcinoma,squamous cell carcinoma3
195139375OR2T5skin,face,carcinoma,squamous cell carcinoma3
196137853P4HTMskin,face,carcinoma,squamous cell carcinoma3
197140533PDGFRBskin,ear,carcinoma,squamous cell carcinoma3
198137629PARP16skin,hand,carcinoma,squamous cell carcinoma3
199139344PAPPA2skin,face,carcinoma,squamous cell carcinoma3
200139254PAK3skin,face,carcinoma,squamous cell carcinoma3
201140636NOXA1skin,ear,carcinoma,squamous cell carcinoma3
202138096NF1skin,face,carcinoma,squamous cell carcinoma3
203137309ZFYVE9skin,hand,carcinoma,squamous cell carcinoma3
204139492MCF2L2skin,face,carcinoma,squamous cell carcinoma3
205140185MATKskin,face,carcinoma,squamous cell carcinoma3
206138755MAPK8skin,face,carcinoma,squamous cell carcinoma3
207138209MSH4skin,face,carcinoma,squamous cell carcinoma3
208138547MSH5skin,face,carcinoma,squamous cell carcinoma3
209138732NEK6skin,face,carcinoma,squamous cell carcinoma3
210140354NCDNskin,ear,carcinoma,squamous cell carcinoma3
211140415MSH6skin,ear,carcinoma,squamous cell carcinoma3
212138172PEX10skin,face,carcinoma,squamous cell carcinoma3
213139918PITPNM1skin,face,carcinoma,squamous cell carcinoma3
214137685PRODH2skin,hand,carcinoma,squamous cell carcinoma3
215138698PTK2skin,face,carcinoma,squamous cell carcinoma3
216140685PTPROskin,ear,carcinoma,squamous cell carcinoma3
217143669PTPRKskin,face,carcinoma,squamous cell carcinoma3
218138813PTPRJskin,face,carcinoma,squamous cell carcinoma3
219139306PTPN22skin,face,carcinoma,squamous cell carcinoma3
220139526PRKG2skin,face,carcinoma,squamous cell carcinoma3
221139688PLGskin,face,carcinoma,squamous cell carcinoma3
222139486PLCH1skin,face,carcinoma,squamous cell carcinoma3
223140250PLCB1skin,face,carcinoma,squamous cell carcinoma3
224138325PKP4skin,face,carcinoma,squamous cell carcinoma3
225140071PMLskin,face,carcinoma,squamous cell carcinoma3
226138652POT1skin,face,carcinoma,squamous cell carcinoma3
227137613PRKD1skin,hand,carcinoma,squamous cell carcinoma3
228138633PPP1R9Askin,face,carcinoma,squamous cell carcinoma3
229137794PPP1R12Bskin,face,carcinoma,squamous cell carcinoma3
230138297PPM1Bskin,face,carcinoma,squamous cell carcinoma3
231140571MAP3K5skin,ear,carcinoma,squamous cell carcinoma3

Expression for genes affiliated with Tongue Squamous Cell Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 30 (show all 29)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1TMPRSS11Btransmembrane protease, serine 11BOral Cavity-5.730.000
2XISTX inactive specific transcript (non-protein coding)Blood-5.170.007
3MALmal, T-cell differentiation proteinOral Cavity-5.070.000
4REG3Aregenerating islet-derived 3 alphaPancreas+5.010.004
5CRNNcornulinOral Cavity-4.970.000
6DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedBlood+4.770.009
7KRT13keratin 13Oral Cavity-4.670.001
8MYH2myosin, heavy chain 2, skeletal muscle, adultOral Cavity-4.120.005
9REG1Pregenerating islet-derived 1 pseudogenePancreas+3.890.011
10USP9Yubiquitin specific peptidase 9, Y-linkedBlood+3.880.012
11CXCL12chemokine (C-X-C motif) ligand 12Oral Cavity-3.730.000
12CLCA4chloride channel accessory 4Oral Cavity-3.650.000
13MMP7matrix metallopeptidase 7 (matrilysin, uterine)Pancreas+3.610.006
14LDB3LIM domain binding 3Oral Cavity-3.410.003
15CLUclusterinOral Cavity-3.380.000
16GALNT16polypeptide N-acetylgalactosaminyltransferase 16Oral Cavity-3.360.000
17TXLNG2Ptaxilin gamma 2, pseudogeneBlood+3.340.019
18REG3Gregenerating islet-derived 3 gammaPancreas+3.330.034
19CRISP3cysteine-rich secretory protein 3Oral Cavity-3.230.010
20CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Oral Cavity-3.210.000
21PCOLCE2procollagen C-endopeptidase enhancer 2Pancreas+3.200.000
22SPINK5serine peptidase inhibitor, Kazal type 5Oral Cavity-3.200.002
23HLA-DRB5major histocompatibility complex, class II, DR beta 5Blood-3.190.040
24TSHRthyroid stimulating hormone receptorPancreas+3.150.003
25SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Pancreas+3.120.000
26KRT4keratin 4Oral Cavity-3.100.000
27ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Oral Cavity-3.100.000
28FAM3Bfamily with sequence similarity 3, member BOral Cavity-3.080.007
29SPRR3small proline-rich protein 3Oral Cavity-3.060.025

Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for genes affiliated with Tongue Squamous Cell Carcinoma

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Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7MIR24-1, MIR195, MIR25

Compounds for genes affiliated with Tongue Squamous Cell Carcinoma

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GO Terms for genes affiliated with Tongue Squamous Cell Carcinoma

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Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of angiogenesisGO:00457669.8TWIST1, ANGPTL4

Sources for Tongue Squamous Cell Carcinoma

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26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet