MCID: TNG009
MIFTS: 57

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Oral diseases

Aliases & Classifications for Tongue Squamous Cell Carcinoma

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 37 12 14
Squamous Cell Carcinoma of Tongue 69
Carcinoma, Squamous Cell 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0050865
MeSH 41 D002294
NCIt 46 C2929

Summaries for Tongue Squamous Cell Carcinoma

Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to squamous cell carcinoma and tongue cancer. An important gene associated with Tongue Squamous Cell Carcinoma is DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are ERK Signaling and Endometrial cancer. The drugs Cetuximab and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the tongue, tongue and lymph node, and related phenotypes are Increased cell migration and cardiovascular system

Related Diseases for Tongue Squamous Cell Carcinoma

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.1 CDH1 CDKN2A DDR2 MMP2 MMP9 TP53
2 tongue cancer 29.0 BMI1 CDH1 CDKN2A CTNNB1 MMP2 MMP9
3 nasopharyngeal carcinoma 28.5 BMI1 CASP3 CDH1 CDKN2A CTNNB1 MMP2
4 squamous cell carcinoma of the oral tongue 11.2
5 brain stem astrocytic neoplasm 10.6 CDKN2A TP53
6 short-rib thoracic dysplasia 4 with or without polydactyly 10.6 CASP3 TP53
7 squamous cell carcinoma of the oropharynx 10.5 CDKN2A TP53
8 extracranial arteriovenous malformation 10.5 MMP2 MMP9
9 spitz nevus 10.5 CDKN2A TP53
10 focal myositis 10.5 MMP2 MMP9
11 cerebral convexity meningioma 10.5 CDH1 TP53
12 vulvar intraepithelial neoplasia 10.5 MMP2 TP53
13 spastic entropion 10.5 MMP2 MMP9
14 lentigo maligna melanoma 10.5 MMP2 MMP9
15 villous adenocarcinoma 10.5 MMP2 MMP9
16 keratinizing squamous cell carcinoma 10.5 CDKN2A TP53
17 adult hepatocellular carcinoma 10.5 CTNNB1 TP53
18 squamous cell carcinoma of the larynx 10.5 CDKN2A TP53
19 infiltrating angiolipoma 10.4 CDKN2A VEGFC
20 acute transverse myelitis 10.4 MMP2 MMP9
21 grade iii astrocytoma 10.4 CDKN2A MMP2 TP53
22 internal hemorrhoid 10.4 CASP3 MMP2 MMP9
23 actinic keratosis 10.4 CDKN2A MMP2 TP53
24 nervous system cancer 10.4 CASP3 CDKN2A TP53
25 pre-malignant neoplasm 10.4 CDH1 CDKN2A TP53
26 female reproductive endometrioid cancer 10.4 CTNNB1 TP53
27 nasal cavity squamous cell carcinoma 10.4 CDKN2A MMP2 MMP9
28 gallbladder adenoma 10.4 CDKN2A CTNNB1
29 in situ carcinoma 10.4 CDH1 CDKN2A TP53
30 malignant ovarian surface epithelial-stromal neoplasm 10.4 CDH1 MMP2 TP53
31 ovary epithelial cancer 10.4 CDH1 MMP2 TP53
32 cholecystitis 10.4 CDH1 CDKN2A TP53
33 cervix small cell carcinoma 10.4 CDH2 CDKN2A TP53
34 large intestine adenocarcinoma 10.4 CDH1 CTNNB1
35 bladder urothelial carcinoma 10.4 CASP3 CDH1 TP53
36 salivary gland cancer 10.4 CASP3 MMP2 MMP9
37 microcystic meningioma 10.4 CDH1 MMP2 MMP9
38 lung giant cell carcinoma 10.4 CDH1 MMP2 MMP9
39 endocrine gland cancer 10.3 CDH1 CDKN2A TP53
40 gliosarcoma 10.3 MMP2 MMP9 TP53
41 bone cancer 10.3 BMI1 CDKN2A MMP9
42 endometrial stromal sarcoma 10.3 MMP2 MMP9 TP53
43 cell type benign neoplasm 10.3 CDKN2A CTNNB1 TP53
44 psammomatous meningioma 10.3 CTNNB1 MMP2 MMP9
45 endometrial adenocarcinoma 10.3 CDKN2A CTNNB1 TP53
46 signet ring cell adenocarcinoma 10.3 CDH1 CTNNB1 TP53
47 intestinal benign neoplasm 10.3 CDH1 CTNNB1 TP53
48 hypotrichosis, congenital, with juvenile macular dystrophy 10.3 CDH1 CDH2
49 epstein-barr virus-associated gastric carcinoma 10.3 CDH1 CDKN2A CTNNB1
50 colorectal adenocarcinoma 10.3 CDH1 CTNNB1 TP53

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell migration GR00055-A-3 8.92 CDH2 CTNNB1 DDR2 VEGFC

MGI Mouse Phenotypes related to Tongue Squamous Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 CASP3 CDH1 CDH2 CDKN2A CTNNB1 DDR2
2 mortality/aging MP:0010768 9.93 CDH2 CDKN2A CTNNB1 DDR2 DND1 MMP2
3 digestive/alimentary MP:0005381 9.8 CASP3 CDH1 CDKN2A CTNNB1 MMP9 SNAI1
4 muscle MP:0005369 9.56 CASP3 CDH2 CDKN2A CTNNB1 DDR2 MMP2
5 neoplasm MP:0002006 9.23 CDH1 CDKN2A CTNNB1 DDR2 DND1 MMP2

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
3
Fluorouracil Approved Phase 2 51-21-8 3385
4
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
5 Anesthetics Phase 2
6 Antimitotic Agents Phase 2
7
Ribavirin Approved 36791-04-5 37542
8 Anti-Infective Agents
9 Antimetabolites
10 Antiviral Agents
11
Luteolin Nutraceutical Early Phase 1 491-70-3 5280445

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Recruiting NCT02985255 Phase 2 Docetaxel;Cisplatin;5FU
3 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062 Phase 1
4 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma Recruiting NCT03440151
5 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 ribavirin
6 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03288298 Early Phase 1 luteolin;nano-luteolin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Cochrane evidence based reviews: carcinoma, squamous cell

Genetic Tests for Tongue Squamous Cell Carcinoma

Anatomical Context for Tongue Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

18
The Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

38
Tongue, Lymph Node, T Cells, Tonsil, Endothelial, Skeletal Muscle, Neutrophil

Publications for Tongue Squamous Cell Carcinoma

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 302)
# Title Authors Year
1
Tumor budding as a novel predictor of occult metastasis in cT2N0 tongue squamous cell carcinoma. ( 29307623 )
2018
2
Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". ( 29449674 )
2018
3
Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma. ( 29286143 )
2018
4
Unusual Multinucleated Giant Cell Reaction in a Tongue Squamous Cell Carcinoma: Histopathological and Immunohistochemical Features. ( 29427031 )
2018
5
Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. ( 29207154 )
2018
6
MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma. ( 29434944 )
2018
7
Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma. ( 29371635 )
2018
8
FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment. ( 29393475 )
2018
9
Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/I^-catenin signaling pathway. ( 29310682 )
2018
10
Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. ( 29449675 )
2018
11
C-reactive protein is associated with the development of tongue squamous cell carcinoma. ( 29385406 )
2018
12
FoxM1 promotes epithelial-mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop. ( 29360662 )
2018
13
Tongue Squamous Cell Carcinoma in a European Lynx (Lynx Lynx): Papillomavirus Infection and Histologic Analysis. ( 29301274 )
2018
14
LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2. ( 29315846 )
2018
15
The maximum standardized uptake value increment calculated by dual-time-point (18)F-fluorodeoxyglucose positron emission tomography predicts survival in patients with oral tongue squamous cell carcinoma. ( 28626254 )
2017
16
An inA vitro study of the long non-coding RNA TUG1 in tongue squamous cell carcinoma. ( 28597931 )
2017
17
IncRNA H19 promotes tongue squamous cell carcinoma progression through I^-catenin/GSK3I^/EMT signaling via association with EZH2. ( 28804564 )
2017
18
Transoral bisected resection for T1-2 oral tongue squamous cell carcinoma to secure adequate deep margin. ( 28939079 )
2017
19
Transoral robotic surgery for the base of tongue squamous cell carcinoma: a preliminary comparison between da Vinci Xi and Si. ( 28905287 )
2017
20
MicroRNA and protein profiles in invasive versus non-invasive oral tongue squamous cell carcinoma cells in vitro. ( 27773646 )
2017
21
hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma. ( 28535002 )
2017
22
Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma. ( 28367232 )
2017
23
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma. ( 27821487 )
2017
24
Mesenchymal stem cell-derived CCN2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells. ( 28208216 )
2017
25
Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma. ( 28775982 )
2017
26
Investigation of proliferation and migration of tongue squamous cell carcinoma promoted by three chemokines, MIP-3I+, MIP-1I^, and IP-10. ( 28919775 )
2017
27
Nomograms to estimate long-term overall survival and tongue cancer-specific survival of patients with tongue squamous cell carcinoma. ( 28411370 )
2017
28
Cardiac metastasis of tongue squamous cell carcinoma complicated by pulmonary embolism: A case report. ( 28700484 )
2017
29
MicroRNAa89509 acts as a tumor suppressor in tongue squamous cell carcinoma by targeting epidermal growth factor receptor. ( 28944863 )
2017
30
Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model. ( 28633143 )
2017
31
Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miRa89375. ( 27878285 )
2017
32
PTK7 is a molecular marker for metastasis, TNM stage, and prognosis in oral tongue squamous cell carcinoma. ( 28547980 )
2017
33
Prognostic significance and function of mammalian target of rapamycin in tongue squamous cell carcinoma. ( 28811537 )
2017
34
Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma. ( 28747140 )
2017
35
Potential factors influencing the development of oral tongue squamous cell carcinoma in young mature patients: Lingual position of the mandibular second molar and narrow tongue space. ( 29344172 )
2017
36
miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/I^-Catenin Pathway in Tongue Squamous Cell Carcinoma. ( 28337453 )
2017
37
The interplay of matrix metalloproteinase-8, transforming growth factor-I^1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. ( 28772283 )
2017
38
MicroRNA-802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4. ( 28319306 )
2017
39
Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma. ( 28413152 )
2017
40
Analysis of the outcome of young age tongue squamous cell carcinoma. ( 29302590 )
2017
41
High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway. ( 29340090 )
2017
42
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma. ( 28700659 )
2017
43
Identii-8cation of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis. ( 29240723 )
2017
44
Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut and alcohol: Case study. ( 29236289 )
2017
45
Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs). ( 27676191 )
2017
46
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins. ( 28570699 )
2017
47
Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta-analysis. ( 28900723 )
2017
48
Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the JAK/STAT3 signaling pathway. ( 28946186 )
2017
49
Receptor for advanced glycation end product blockade enhances the chemotherapeutic effect of cisplatin in tongue squamous cell carcinoma by reducing autophagy and modulating the Wnt pathway. ( 27831944 )
2017
50
Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells. ( 28928824 )
2017

Variations for Tongue Squamous Cell Carcinoma

ClinVar genetic disease variations for Tongue Squamous Cell Carcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DDR2 NM_001014796.2(DDR2): c.2304T> A (p.Ser768Arg) single nucleotide variant Pathogenic rs267598140 GRCh37 Chromosome 1, 162748390: 162748390

Cosmic variations for Tongue Squamous Cell Carcinoma:

9 (show top 50) (show all 104)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 13
2 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 13
3 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 13
4 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 13
5 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 13
6 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 13
7 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 13
8 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 13
9 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 13
10 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 13
11 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 13
12 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 13
13 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 13
14 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 13
15 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 13
16 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 13
17 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 13
18 COSM45275 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.559G>T p.G187C 13
19 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 13
20 COSM10771 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.749C>T p.P250L 13
21 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 13
22 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 13
23 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 13
24 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 13
25 COSM11089 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.584T>C p.I195T 13
26 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 13
27 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 13
28 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 13
29 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 13
30 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 13
31 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 13
32 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 13
33 COSM43947 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 13
34 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 13
35 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 13
36 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 13
37 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 13
38 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 13
39 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 13
40 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 13
41 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 13
42 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 13
43 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 13
44 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 13
45 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 13
46 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 13
47 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 13
48 COSM763 PIK3CA upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1633G>A p.E545K 13
49 COSM777 PIK3CA upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.3145G>A p.G1049S 13
50 COSM21436 PIK3CA upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1028A>G p.Y343C 13

Expression for Tongue Squamous Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for Tongue Squamous Cell Carcinoma

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CASP3 CDH1 CDH2 CDKN2A CTNNB1 DDR2
2
Show member pathways
12.98 CASP3 CDH1 CDKN2A CTNNB1 MMP9 TP53
3
Show member pathways
12.67 CASP3 CDH1 DDR2 MMP2 MMP9
4
Show member pathways
12.63 CASP3 CDH1 CTNNB1 SNAI1 TP53
5 12.58 CASP3 CDH1 CDKN2A CTNNB1 MMP2 MMP9
6
Show member pathways
12.46 CDKN2A MMP2 MMP9 TP53 VEGFC
7
Show member pathways
12.42 CASP3 CDH1 CTNNB1 TP53
8 12.35 CDH1 CDH2 CTNNB1 TP53
9 12.35 BMI1 CASP3 CDKN2A MMP9 TP53
10 12.11 CASP3 CTNNB1 MMP2 MMP9 TP53
11 12.04 CASP3 CDH1 CTNNB1 TP53
12 11.98 CASP3 CDH1 CDH2 CTNNB1
13 11.96 CDKN2A CTNNB1 MMP2 TP53
14 11.94 CTNNB1 MMP2 MMP9 TP53
15 11.83 CASP3 MMP2 VEGFC
16 11.77 MMP2 MMP9 VEGFC
17 11.77 CDH1 CDH2 CTNNB1 SNAI1
18 11.67 CASP3 CDKN2A TP53
19 11.66 CDH1 CTNNB1 SNAI1
20 11.65 CASP3 CDH1 CTNNB1 MMP2 MMP9 TP53
21 11.64 BMI1 MMP9 SNAI1 TP53
22 11.61 CASP3 MMP2 MMP9
23 11.59 CASP3 MMP2 MMP9
24 11.57 CDH1 CTNNB1 MMP2 MMP9
25 11.53 CASP3 CTNNB1 MMP9
26 11.49 CDKN2A TP53 VEGFC
27 11.45 CDKN2A MMP2 TP53
28 11.42 CDH1 CDKN2A MMP2 MMP9 TP53
29 11.41 CDH1 CDH2 MMP9
30 11.29 CDH1 CDH2 CTNNB1
31 11.18 CDH1 CDH2 CTNNB1 DDR2 MMP2 MMP9
32 10.76 CDH1 CTNNB1
33 10.75 CDH1 CDH2 SNAI1

GO Terms for Tongue Squamous Cell Carcinoma

Cellular components related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adherens junction GO:0005913 9.43 CDH1 CDH2 CTNNB1
2 apical junction complex GO:0043296 9.32 CDH1 CTNNB1
3 fascia adherens GO:0005916 9.16 CDH2 CTNNB1
4 flotillin complex GO:0016600 8.96 CDH1 CTNNB1
5 catenin complex GO:0016342 8.8 CDH1 CDH2 CTNNB1

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.55 CASP3 CDKN2A CTNNB1 MMP9 TP53
2 extracellular matrix disassembly GO:0022617 9.54 CDH1 MMP2 MMP9
3 replicative senescence GO:0090399 9.46 CDKN2A TP53
4 entry of bacterium into host cell GO:0035635 9.43 CDH1 CTNNB1
5 positive regulation of neuron apoptotic process GO:0043525 9.43 CASP3 CTNNB1 TP53
6 morphogenesis of embryonic epithelium GO:0016331 9.4 CTNNB1 VEGFC
7 response to drug GO:0042493 9.35 CASP3 CDH1 CTNNB1 TP53 VEGFC
8 cellular response to indole-3-methanol GO:0071681 9.32 CDH1 CTNNB1
9 adherens junction organization GO:0034332 8.8 CDH1 CDH2 CTNNB1

Molecular functions related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.32 CASP3 CDKN2A
2 gamma-catenin binding GO:0045295 9.26 CDH1 CDH2
3 alpha-catenin binding GO:0045294 9.16 CDH2 CTNNB1
4 protein phosphatase binding GO:0019903 9.13 CDH2 CTNNB1 TP53
5 disordered domain specific binding GO:0097718 8.8 CDKN2A CTNNB1 TP53

Sources for Tongue Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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43 MGI
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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