Tonsillitis malady

Disease Ontology: An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.⁶

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to tongue cancer and rheumatoid arthritis. An important gene associated with Tonsillitis is BPIFB2 (BPI fold containing family B, member 2), and among its related pathways are Immune System and Chemokine Signaling. The drugs cefprozil and dirithromycin and the compounds ionomycin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and liver, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Tonsillitis is inflammation of the tonsils most commonly caused by a viral or bacterial infection whose...⁴⁴ more...

Aliases & Descriptions:

tonsillitis 6 8 32 43 chronic tonsillitis 6 32 43 throat infection - tonsillitis 6 chronic tonsillitis (disorder) 6

tonsillitis (disorder) 6 tonsillitis, nos 6 pharyngitis 43

Diseases related to tonsillitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 952)

id	Related Disease	Score	Top Affiliating Genes
1	tongue cancer	27.8	PDCD1, SERPINB5, VIM, VEGFA, BCL2, CD69
2	rheumatoid arthritis	27.8	MBL2, SRF, CRP, LTA
3	b-cell lymphomas	27.1	CLU, PAX5, BCL2, BCL6, MS4A1, CDKN1B
4	haemophilus influenzae	27.0	LACTB, IL10, IL1A, IL2RA, ICAM1, CAT
5	aphthous stomatitis	26.5	CFI, CD69, CD40, IL10, IL1A, IL2
6	stomatitis	26.5	CFI, CD79A, CD69, CD4, CD40, IL10
7	pharyngitis	26.1	VIM, VEGFA, BDNF, BCL2, LEPREL1, MUC1
8	diphtheria	25.9	VEGFA, BCL2, CD79A, CD4, CD40LG, IL2
9	guillain-barre syndrome	25.3	CD79A, CD40LG, IL10, MBL2, CCR5, CCL21
10	rheumatic fever	25.2	CD79A, CDKN2A, CD40LG, IL1A, IL2, IL2RA
11	ataxia telangiectasia	25.1	VIM, RAG2, RAG1, BCL2, BCL6, CD79A
12	adult-onset still's disease	24.9	CD4, MIF, IL2RA, FASLG, CCL2, ICAM1
13	squamous cell carcinoma	24.9	SERPINB5, VIM, VEGFA, CMA1, CLDN4, CLDN7
14	laryngeal cancer	24.8	VEGFA, CLDN7, BCL2, MUC1, CD79A, CDKN1B
15	atopic dermatitis	24.7	CMA1, BDNF, S100A7, CD69, CD14, CD40
16	familial mediterranean fever	24.1	VEGFA, CD14, IL10, IL2RA, IFNG, TNF
17	sleep apnea	24.0	BDNF, CD79A, CD40LG, IL10, IL4, CCL2
18	apnea	24.0	BDNF, CD79A, CD40LG, IL10, IL4, ENO2
19	adenoiditis	24.0	SERPINB5, VIM, VEGFA, CLU, BCL2, BCL6
20	immunodeficiency	23.9	PDCD1, CISH, S100A12, CD79A, CD69, CD70
21	myopathy	23.4	VIM, LILRB1, CLU, BDNF, BCL2, LAIR1
22	influenza	23.1	LILRB1, LACTB, LAIR1, CD79A, CD27, CD69
23	laryngeal carcinoma	22.8	SERPINB5, VEGFA, BCL2, MUC1, MTA1, S100A1
24	nephropathy	22.8	PDCD1, VEGFA, CMA1, CLU, CISH, CD79A
25	laryngitis	22.2	SERPINB5, VIM, VEGFA, CLDN7, CLU, BCL2
26	nasopharyngitis	21.1	PDCD1, SERPINB5, VIM, VEGFA, BPIFB2, CLDN4
27	diffuse large b-cell lymphoma	20.5	CNR2, VEGFA, RAG1, PAX5, BCL2, BCL6
28	dermatitis	20.5	VIM, VEGFA, CMA1, BDNF, BCL2, MUC1
29	carcinoma	19.6	ZNF673, PDCD1, CNR2, SERPINB5, VIM, VEGFA
30	arthritis	16.5	PILRA, PDCD1, CNR2, SERPINB5, VIM, VEGFA
31	adenoma	15.9	SERPINB5, VIM, VEGFA, CLDN4, CLDN7, CLU
32	cervicitis	15.0	PDCD1, SERPINB5, VIM, VEGFA, CMA1, CLDN7
33	thyroiditis	14.9	CNR2, SERPINB5, VIM, VEGFA, RAG2, LILRB1
34	impetigo	14.2	CD79A, CD40LG, HSF4, CRYGC, EDNRA, DSG1
35	ritter's disease	14.1	HSF4, EDNRA, DSG1, DSG3
36	scarlet fever	14.0	LEPREL1, CRYGC, KSR1, EDNRA
37	central nervous system lymphoma, primary	14.0	PAX5, BCL6, IGHM, CXCL13, CXCR5
38	vulvovaginal candidiasis	14.0	CD79A, IL4, MBL2, DEFB1, DEFB4A
39	immunodeficiency with hyper igm	14.0	CD79A, CD40LG, CD40, AICDA
40	cd40 ligand deficiency	14.0	CD79A, CD40LG, CD40, AICDA, SRF
41	hereditary pancreatitis	14.0	SERPINB5, CLU, IGES, CTSE, KRT8, KRAS
42	down syndrome	14.0	BCL6, UBE3A, CGB7, CD38, ANPEP, IGHM
43	respiratory failure	13.9	CMA1, LACTB, IGES, CAT, CYSLTR1, EPX
44	lymphoblastic lymphoma	13.9	RAG1, PAX5, BCL6, MS4A1, ENO2, DPP4
45	localized scleroderma	13.9	CD40LG, IL2RA, IL4, DEFB1, DEFB4A, DEFB103B
46	extrinsic allergic alveolitis	13.9	CD14, CD80, IL1A, CXCL5
47	immunodeficiency with hyper igm type 1	13.9	CD79A, CD40LG, CD40, IL4, AICDA
48	cd40 deficiency	13.8	CD40LG, CD40, AICDA
49	primary biliary cirrhosis	13.8	PDCD1, CD79A, CD40LG, MBL2, ALPP, SP100
50	oxyphilic adenoma	13.7	VIM, CLDN7, MUC1, S100A1, KRT8, DEFB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 azithromycin, azithromycin dihydrate, cefaclor, cefaclor monohydrate, cefadroxil, cefadroxil monohydrate, cefdinir, cefditoren, cefditoren pivoxil, cefpodoxime proxetil, cefprozil, ceftibuten, ceftibuten dihydrate, ceftibutin, cefuroxime, cefuroxime axetil, cefuroxime sodium, cephalexin, cephalexin hydrochloride, cephalexin monohydrate, clarithromycin, dirithromycin, guaifenesin

MalaCards organs/tissues related to tonsillitis:

²²

MGI Mouse Phenotypes related to tonsillitis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	RAG2, RAG1, BDNF, BCL6, CD14, IL33
2	hematopoietic system phenotype	MP:0005397	10.7	PDCD1, RAG2, RAG1, CLDN7, CLEC6A, ZFAT
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	LHX1, CDKN1B, CD40LG, ITGA3, IL2, FANCD2
4	craniofacial phenotype	MP:0005382	9.7	RAG2, BDNF, LHX1, GRHL3, GJA1, TP73
5	embryogenesis phenotype	MP:0005380	9.3	SERPINB5, VIM, ZFAT, LHX1, ITGA5, ITGB7
6	renal/urinary system phenotype	MP:0005367	8.8	PDCD1, RAG1, CLDN7, CLU, CLEC6A, BCL2
7	liver/biliary system phenotype	MP:0005370	8.8	VEGFA, RAG2, RAG1, BCL6, IL2, FAM20B
8	no phenotypic analysis	MP:0003012	8.7	VEGFA, BDNF, LHX1, MUC1, UBE3A, CD79A
9	nervous system phenotype	MP:0003631	8.3	PDCD1, RAG2, RAG1, CLDN14, PAX5, BDNF
10	normal phenotype	MP:0002873	8.1	VEGFA, RAG2, RAG1, PAX5, BDNF, LHX1
11	immune system phenotype	MP:0005387	7.9	CNR2, VIM, CMA1, CLU, CLEC6A, PAX5
12	pigmentation phenotype	MP:0001186	7.8	RAG1, BCL2, ATRN, CDKN1B, CDKN2A, ITGB1
13	hearing/vestibular/ear phenotype	MP:0005377	7.8	RAG1, CLDN14, PAX5, BDNF, BCL2, CDKN1B
14	skeleton phenotype	MP:0005390	7.7	VEGFA, RAG2, CD69, CD14, CDKN2A, CD44
15	integument phenotype	MP:0010771	7.5	CNR2, RAG2, RAG1, CLDN7, BDNF, BCL2
16	digestive/alimentary phenotype	MP:0005381	7.4	VEGFA, RAG2, RAG1, BDNF, BCL2, MUC1
17	behavior/neurological phenotype	MP:0005386	7.2	VIM, RAG2, RAG1, CLDN14, PAX5, BDNF
18	growth/size phenotype	MP:0005378	7.1	RAG2, RAG1, CLDN7, PAX5, BDNF, BCL2
19	mortality/aging	MP:0010768	7.0	PDCD1, SERPINB5, VEGFA, RAG2, RAG1, CLDN7
20	reproductive system phenotype	MP:0005389	6.8	VEGFA, RAG2, BCL6, LHX1, CHST15, UBE3A
21	tumorigenesis	MP:0002006	4.9	RAG2, RAG1, BCL2, MUC1, CDKN1B, CDKN2A
22	muscle phenotype	MP:0005369	4.6	PDCD1, VIM, VEGFA, CLU, BCL2, BCL6
23	vision/eye phenotype	MP:0005391	4.3	PDCD1, VIM, VEGFA, RAG1, BDNF, BCL2
24	homeostasis/metabolism phenotype	MP:0005376	4.3	VIM, VEGFA, RAG2, RAG1, CLDN7, CLU
25	cardiovascular system phenotype	MP:0005385	3.8	PDCD1, VIM, VEGFA, RAG2, RAG1, CLU
26	cellular phenotype	MP:0005384	3.1	PDCD1, SERPINB5, VIM, VEGFA, RAG2, RAG1

Articles related to tonsillitis:

(show top 50)    (show all 124)

id	Title	Authors	Year	Affiliating Genes
1	Identification and immunolocalization of the innate i mmune receptor CD14 in hypertrophic adenoids and tonsils. (21062235)	Ben-Yaakov A.... Gross M.	2011	CD14
2	Relationships between metastasis-associated protein ( MTA) 1 and lymphatic metastasis in tonsil cancer. (21240515)	Park J.O.... Kim M.S.	2011	MTA1
3	Microarray analysis of tonsils in immunoglobulin A ne phropathy patients. (20138841)	Iio K.... Rakugi H.	2010	CALB2, APOBEC2
4	MBL expression in patients with recurrent tonsillitis . (19716183)	Grasso D.L.... Crovella S.	2009	MBL2
5	Prognostic significance of vascular endothelial growt h factor in squamous cell carcinomas of the tonsil in relation to human papillo mavirus status and epidermal growth factor receptor. (19603236)	Fei J.... Rose B.	2009	EGFR, VEGFA
6	The effect of proteasome inhibition on p53 degradatio n and proliferation in tonsil epithelial cells. (18283158)	Harris G.F.... Lee J.H.	2008	TP53
7	Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells. (18097679)	Verbrugghe P.... Cuvelier C.A.	2008	CLU
8	Expression of endothelial and inducible nitric oxide synthase and caspase-3 in tonsillar cancer, chronic tonsillitis and healthy tonsils. (19178812)	Lukes P.... Astl J.	2008	CASP3, NOS3, NOS2
9	Differentiated S100A7 expression in infected tonsils and tonsils from allergic individuals. (18625016)	Bryborn M.... Adner M.	2008	S100A7
10	Is IgA nephropathy induced by abnormalities of CD4+CD25+Treg cells in the tonsils? (17324527)	Huang H.... Lei H.	2007	CD79A
11	Tonsil epithelial factors may influence oropharyngeal human immunodeficiency virus transmission. (17620369)	Moutsopoulos N.M.... Wahl S.M.	2007	CXCR4, CCR5
12	The effect of recurrent tonsillitis and adenotonsillectomy on growth in childhood. (17850885)	Aydogan M.... Gokalp A.S.	2007	IGF1, IGFBP3
13	Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report. (16325925)	Lesmeister M.J.... Misfeldt M.L.	2006	TLR8
14	Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. (16504163)	Mansson A.... Cardell L.O.	2006	TLR1, TLR10
15	Differential proteome analysis of tonsils from children with chronic tonsillitis or with hyperplasia reveals disease-associated protein expression differences. (16479370)	Just T.... Glocker M.O.	2006	CMPK1
16	Investigation of the role of ribonuclease L gene in the response of tonsil tissues against viral infections (17205688)	Sahin F.... Gerceker D.	2006	RNASEL
17	Regulation of the tonsil cytokine milieu favors HIV susceptibility. (16943383)	Moutsopoulos N.M.... Wahl S.M.	2006	IL4, CISH
18	Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis. (16786155)	Bronzetti E.... Fumagalli L.	2006	NTRK1, NTRK2, NTRK3
19	Defensin and chemokine expression patterns in the palatine tonsil: a model of their local interaction. (16362266)	Meyer J.E.... Maune S.	2006	CCL13, CCL7, DEFA1
20	The correlation of micro-organisms between tonsillar crypt culture and tonsillar core culture in chronic tonsillitis. (16858946)	Mahakit P.... Chantaratchada S.	2005	LACTB
21	Activation of human tonsil and skin mast cells by ago nists of proteinase activated receptor-2. (15842775)	He S.H.... Fu Y.L.	2005	F2RL1
22	Expression of chemokine receptors in normal and inflamed human intestine, tonsil, and liver--an immunohistochemical analysis with new monoclonal antibodies from the 8th international workshop and conference on human leucocyte differentiation antigens. (16185674)	Autschbach F.... Gassler N.	2005	CCR9
23	Immunity of tonsil and IgA nephropathy--relationship between IgA nephropathy and tonsillitis. (15768789)	Kuki K.... Yamanaka N.	2004	CCL2
24	Biologically active neutrophil chemokine pattern in tonsillitis. (15008987)	Rudack C.... Sachse F.	2004	CXCL1, CXCL6
25	Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking. (14761935)	Palmeri D.... Hemmerich S.	2004	SERPINB5, CFI, SPARCL1
26	Differential expression of cysteinyl leukotriene receptors 1 and 2 in tonsils of children with obstructive sleep apnea syndrome or recurrent infection. (15249436)	Goldbart A.D.... Gozal D.	2004	CYSLTR1
27	Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis. (15545061)	Shimizu T.... Nishihira J.	2004	MIF
28	CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides. (12778475)	Gantner F.... Bacon K.B.	2003	CD40, IL10, TLR9
29	Quantitative cytokine gene expression in human tonsils at excision and during histoculture assessed by standardized and calibrated real-time PCR and novel data processing. (14659897)	Bonanomi A.... Nadal D.	2003	IL15, HMBS
30	Decreased serum and pharyngeal antibody levels specific to streptococcal lipoteichoic acid in children with recurrent tonsillitis. (11997155)	Yokoyama Y.... Harabuchi Y.	2002	CD79A
31	Tonsillar and erythrocyte levels of superoxide dismutase in children with and without recurrent tonsillitis (11927098)	GarcA-a Callejo F.J.... Blay Galaud L.	2002	SOD1
32	Immunolocalization of inducible nitric oxide synthase and 3-nitrotyrosine in recurrently inflamed, human palatine tonsils. (12235514)	Wang H.W.... Kang B.H.	2002	NOS2
33	Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils. (11781235)	Meru N.... Niedobitek G.	2002	EFNA5
34	Oxidative profile of tonsil infection. Study of antioxidant enzymes in tonsil and blood (12402489)	GarcA-a Callejo F.J.... Marco Algarra J.	2002	SOD1
35	Changes in human lymphocyte subpopulations in tonsils and regional lymph nodes of human head and neck squamous carcinoma compared to control lymph nodes. (11316463)	Vidal-Rubio B.... GambA^n-Deza F.	2001	CD69
36	RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. (11123315)	Girschick H.J.... Lipsky P.E.	2001	RAG1, RAG2
37	Detection and cellular localization of 12R-lipoxygenase in human tonsils. (11368351)	Schneider C.... Brash A.R.	2001	ALOX12B
38	Significance of free radicals in chronic tonsillitis. (10920537)	Shukla G.K.... Shanker K.	2000	SOD1
39	The clinical meaning and determination of the superoxid dismutase activity and malondialehyde content in the serum of the patients suffering from chronic tonsillitis (11189145)	Wang W.... Han L.	1998	SOD1
40	Divalent cation-activated-ATPase and ecto 5'-nucleoti dase activities in chronic tonsillitis. (9894864)	AvramoviA8 V.... StefanoviA8 V.	1998	DNAH8
41	Beta-lactamase-producing bacteria in recurrent childhood tonsillitis (9951080)	De Miguel MartA-nez I.... Ramos MacA-as A.	1998	LACTB
42	Bacteriology of normal and diseased tonsils assessed by fine-needle aspiration: Haemophilus influenzae and the pathogenesis of recurrent acute tonsillitis. (9597292)	Gaffney R.J.... Cafferkey M.T.	1998	LACTB
43	A study of free radicals and scavenging enzyme in tonsillitis. (9066174)	Shukla G.K.... Shanker K.	1996	SOD1
44	Subepithelial B cells in the human palatine tonsil. I. Morphologic, cytochemical and phenotypic characterization. (8814243)	Dono M.... Ferrarini M.	1996	TFRC
45	Subepithelial B cells in the human palatine tonsil. II. Functional characterization. (8814244)	Dono M.... Ferrarini M.	1996	CD80
46	Distribution of neurotrophin receptors in human palatine tonsils: an immunohistochemical study. (7759602)	Hannestad J.... Vega J.A.	1995	HCLS1
47	Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. (7805681)	Mitchelmore I.J.... Tabaqchali S.	1994	LACTB
48	Immunohistochemical detection of co-localizing cytokine and antibody producing cells in the extrafollicular area of human palatine tonsils. (8348748)	Hoefakker S.... Claassen E.	1993	IL1A
49	Expression of beta 1-integrins, H-CAM (CD44) and LECAM-1 in primary gastro-intestinal B-cell lymphomas as compared to the adhesion receptor profile of the gut-associated lymphoid system, tonsil and peripheral lymph node. (1720425)	MAPller P.... Koretz K.	1991	ITGB1, CD44, ITGA1
50	Immunohistological study on human palatine tonsils in cases with pustulosis palmaris et plantaris--the quantitative study by image analyzer (2181093)	Matsuyama H.... Yamanaka N.	1990	CD79A

Genes related to tonsillitis according to GeneCards:

(show top 50)    (show all 224)

id	Symbol	Description	Score	GeneCards Section Context
1	BPIFB2	BPI fold containing family B, member 2	11.0	Expressions, Summaries
2	TLR10	toll-like receptor 10	11.0	Publications, Summaries, Expressions
3	LACTB	lactamase, beta	11.0	Publications
4	SOD1	superoxide dismutase 1, soluble	11.0	Publications
5	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
6	CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	11.0	Publications
7	DEFB1	defensin, beta 1	11.0	Publications
8	DEFB4A	defensin, beta 4A	11.0	Publications
9	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
10	MTA1	metastasis associated 1	11.0	Publications
11	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
12	IL1A	interleukin 1, alpha	11.0	Publications
13	EDNRA	endothelin receptor type A	11.0
14	DEFB113	defensin, beta 113	10.9	Disorders
15	SCGB1D4	secretoglobin, family 1D, member 4	10.9	Expressions
16	DEFB103A	defensin, beta 103A	10.9	Expressions
17	SPINK9	serine peptidase inhibitor, Kazal type 9	10.9	Expressions
18	LEAP2	liver expressed antimicrobial peptide 2	10.9	Disorders
19	FCRLB	Fc receptor-like B	10.9	Expressions
20	NTAN1	N-terminal asparagine amidase	10.9	Publications
21	CHRNA10	cholinergic receptor, nicotinic, alpha 10 (neuronal)	10.9	Expressions
22	SSX2B	synovial sarcoma, X breakpoint 2B	10.9	Expressions
23	C6orf15	chromosome 6 open reading frame 15	10.9	Expressions
24	ETV2	ets variant 2	10.9
25	FDCSP	follicular dendritic cell secreted protein	10.9	Expressions
26	IL1F10	interleukin 1 family, member 10 (theta)	10.9	Expressions
27	BPIFB6	BPI fold containing family B, member 6	10.9	Expressions
28	PDZD11	PDZ domain containing 11	10.9	Disorders
29	PGLYRP4	peptidoglycan recognition protein 4	10.9	Expressions
30	PILRA	paired immunoglobin-like type 2 receptor alpha	10.9	Expressions
31	FCRLA	Fc receptor-like A	10.9	Expressions
32	PGLYRP3	peptidoglycan recognition protein 3	10.9	Expressions
33	SERPINB11	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)	10.9	Expressions
34	EFNA4	ephrin-A4	10.9	Functions
35	OTUB1	OTU domain, ubiquitin aldehyde binding 1	10.9	Expressions
36	CLECL1	C-type lectin-like 1	10.9	Expressions
37	HLX	H2.0-like homeobox	10.9	Expressions
38	IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	10.9	Publications
39	CCL15	chemokine (C-C motif) ligand 15	10.9	Publications
40	TMEM8A	transmembrane protein 8A	10.9	Expressions
41	LHX1	LIM homeobox 1	10.9	Expressions
42	ULBP1	UL16 binding protein 1	10.9	Expressions
43	LST1	leukocyte specific transcript 1	10.9	Expressions
44	APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	10.9	Publications
45	SPRR3	small proline-rich protein 3	10.9	Publications
46	CLEC17A	C-type lectin domain family 17, member A	10.9	Expressions
47	TLR8	toll-like receptor 8	10.9	Publications
48	CLEC6A	C-type lectin domain family 6, member A	10.9	Expressions
49	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	10.9	Publications
50	IL36B	interleukin 36, beta	10.9	Expressions

Pathways related to tonsillitis according to GeneDecks:

(show top 50)    (show all 114)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	10.9	PDCD1, LILRB1, ULBP1, ZBP1, CISH, S100A12
2	Chemokine Signaling36	10.8	CCL8, CCL15, CCL7, CCL2, CCR5, CCR1
3	Chemokine signaling pathway20	10.7	CCL8, CCL15, CCL7, CCL2, CCR5, CCR1
4	Phagocytosis of Microbes36	10.7	ITGA1, ITGA3, ITGA5, ITGAE, ITGB1, ITGB7
5	Transendothelial Migration of Leukocytes36	10.6	CLDN4, CLDN7, CLDN14, ITGA1, ITGA3, ITGA5
6	Cell adhesion molecules (CAMs)20	10.5	CLDN4, CLDN7, CLDN14, CD4, CD80, CD40
7	RAR-Gamma-RXR-Alpha Degradation36	10.5	UBE3A, CD80, IL15, IL16, IL2, IL7
8	Lymphocyte Signaling3	10.3	RAG1, PAX5, BCL6, CD4, CD44, IL2RA
9	Class A/1 (Rhodopsin-like receptors)38	10.3	CNR2, CCL7, CCR1, CCL21, CCR9, CX3CL1
10	Regulation of eIF4 and p70S6K36	10.3	CD4, CD80, ITGA1, ITGA3, ITGA5, ITGAE
11	IL-6 Pathway36	10.3	CD80, IL10, IL16, IL4, IL7, CCL8
12	PGC1Alpha Pathway36	9.9	BCL2, CD4, CD80, IL15, IL16, IL1A
13	NFAT Signaling and Lymphocyte Interactions36	9.7	BCL2, CD4, CD80, IL15, IL16, IL1A
14	ERK Signaling36	9.7	CD80, ITGA1, ITGA3, ITGA5, ITGAE, ITGB1
15	Intestinal immune network for IgA production20	9.7	CD40LG, CD80, CD40, ITGB7, IL10, IL15
16	Actin-Based Motility by Rho Family GTPases36	9.7	BDNF, ITGAE, ITGB7, IL2, IGF1, NTRK1
17	Rac1 Pathway36	9.5	BDNF, ITGA1, ITGA3, ITGA5, ITGAE, ITGB1
18	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	BCL2, IL15, IL2, IL2RA, FASLG
19	SOCS Pathway36	9.4	BCL2, CISH, CD4, CD80, IL10, IL15
20	Hematopoietic cell lineage20	9.2	MS4A1, CD14, CD4, CD44, CD38, ITGA1
21	Glucocorticoid Receptor Signaling36	9.2	BCL2, CD4, CD80, IL10, IL15, IL16
22	Endothelin-1 Signaling Pathway36	9.1	CD80, IL10, IL16, IL1A, IL2, IL4
23	Th1 Differentiation37	9.1	CD4, CD80, IL10, IL12RB1, IL2, IFNG
24	JNK Pathway36	8.9	BCL2, CD4, CD80, IL2, IL2RA, CCL8
25	Cytokine Network36	8.8	IL10, IL15, IL16, IL1A, IL2, IL4
26	Pertussis20	8.8	CD14, ITGA5, ITGB1, IL10, IL1A, CASP3
27	Rheumatoid arthritis20	8.7	VEGFA, CD80, IL15, IL1A, CCL2, IFNG
28	PTEN Pathway36	8.7	BDNF, ITGA1, ITGA3, ITGAE, ITGB7, IL2
29	all-trans-Retinoic Acid Signaling in Brain36	8.7	BCL2, CD80, IL10, IL15, IL16, IL1A
30	Malaria20	8.6	CD40LG, CD40, IL10, CCL2, IFNG, ICAM1
31	MIF Mediated Glucocorticoid Regulation36	8.6	BCL2, CD14, CD80, MIF, IL10, IL15
32	PEDF Induced Signaling36	8.5	BDNF, BCL2, CD80, IL10, IL15, IL16
33	Immune response MIF-mediated glucocorticoid regulation10	8.5	CD74, MIF, IL2, IFNG, ICAM1, TNF
34	Akt Signaling36	8.5	CD4, CD80, ITGA1, ITGAE, IL10, IL12RB1
35	Allograft rejection20	8.5	CD40LG, CD80, CD40, IL10, IL2, IL4
36	Rho Family GTPases36	8.4	VIM, BDNF, BCL2, CD80, ITGA1, ITGA3
37	PPAR Pathway36	8.3	ITGA1, ITGA3, ITGA5, ITGAE, ITGB1, ITGB7
38	TGF-Beta Pathway36	8.2	BDNF, BCL2, CD4, CD80, IL10, IL15
39	STAT3 Pathway36	8.2	BCL2, CD4, CD80, IL10, IL12RB1, IL15
40	MIF Regulation of Innate Immune Cells36	8.1	BCL2, CD14, CD80, MIF, IL10, IL15
41	Molecular Mechanisms of Cancer36	8.0	BDNF, BCL2, CDKN1B, CDKN2A, CD4, CD80
42	Tec Kinases Signaling36	7.6	BDNF, BCL2, CD4, CD80, ITGA1, ITGA3
43	Cytokine-cytokine receptor interaction20	7.5	VEGFA, CD27, CD70, CD40LG, CD40, IL10
44	MAPK Family Pathway36	7.5	BDNF, BCL2, CD4, CD80, IL10, IL12RB1
45	JAK-STAT Pathway36	7.4	BDNF, BCL2, CD4, CD80, IL10, IL15
46	MAPK Signaling36	7.1	BDNF, BCL2, ITGA1, ITGA3, ITGA5, ITGAE
47	PAK Pathway36	6.9	BDNF, BCL2, CD80, IL10, IL15, IL16
48	Antioxidant Action of Vitamin-C36	6.8	BDNF, BCL2, CD4, CD80, IL10, IL12RB1
49	Cellular Apoptosis Pathway36	6.2	BDNF, BCL2, CDKN2A, IL2, IL2RA, IGF1
50	p38 Signaling36	6.0	BDNF, BCL2, CD4, CD80, IL10, IL12RB1

Compounds related to tonsillitis according to GeneDecks:

(show top 50)    (show all 312)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.7	RAG1, CD69, CD70, CD40, IL12RB1, IL7
2	cyclophosphamide32 34 9 9	13.7	BCL6, MS4A1, MBL2
3	heparin32 9 18 9	13.3	VIM, CMA1, CD79A, CD69, CD4, ITGB1
4	ccl432	9.9	IL15, IL16, IL7, CCL8, CCL15, CCL7
5	pge232	9.9	CD69, CD14, CD4, IL1A, FASLG, CCL21
6	endotoxin32	9.8	CD14, CD40, ITGB1, MIF, FASLG, CCL8
7	ivig32	9.7	S100A12, FASLG, CCR5, AICDA, CRP, LTA
8	allergens32	9.7	PDCD1, CMA1, CD79A, CD69, CD14, CD40LG
9	calcium32 9 18 9	12.3	LILRB1, CMA1, CLDN4, CLDN14, PAX5, BDNF
10	calcitriol32 42 9 18 9	13.2	CLU, PAX5, CFI, CDKN1B, CD14, CD44
11	estrogen32	9.1	ZNF673, SERPINB5, CLDN4, CLU, BDNF, CISH
12	aspartate32	9.1	VIM, RAG1, BDNF, CD14, CDKN2A, CD40LG
13	steroid32	9.1	ZNF673, SERPINB5, CLU, PAX5, BDNF, CISH
14	progesterone32 42 9 18 9	12.9	SERPINB5, CLU, BCL2, MTA1, S100A1, CGB7
15	tuberculin32	8.9	CD79A, CD69, CD14, CD40LG, MIF, IL10
16	cysteine32	8.8	RAG1, LILRB1, CMA1, CLU, MUC1, UBE3A
17	rapamycin32 42	9.8	VIM, VEGFA, BDNF, CD80, IL2, CCR5
18	cyclosporin a32 42	9.5	CD69, CD14, CD80, CD40, CD44, ITGB1
19	matrigel32	8.5	SERPINB5, VIM, VEGFA, CLU, BDNF, MUC1
20	oligonucleotide32	8.4	ZNF673, VIM, CLDN7, CLU, PAX5, BCL2
21	acetylcholine32 9 18 9	11.4	VIM, BDNF, S100A1, CD79A, CD40LG, CD38
22	tarc32	8.3	CD4, IL10, IL1A, IL4, CCL8, CCL7
23	oxygen32 18	9.3	CLU, BDNF, BCL2, S100A7, CD69, CDKN1B
24	rituximab32 34 9 9	10.9	PAX5, BCL2, BCL6, MS4A1, CD79A, CD40LG
25	superoxide32 18	8.9	CLU, CD14, CD40, IL15, IL16, MBL2
26	creatinine32	7.7	BDNF, MUC1, CFI, CD79A, CD69, CD14
27	indomethacin32 9 9	9.5	VIM, BDNF, CD79A, CD40LG, CD40, IL1A
28	rantes32	7.5	CD70, CD14, CD4, CD40LG, CD40, CD44
29	okt332	7.4	CD79A, CD40LG, IL10, IL15, IL2, IL2RA
30	herbimycin a32 42	8.3	CD69, CD14, CD4, CD40LG, CD40, ITGB1
31	histamine32 18	8.3	VIM, CMA1, BDNF, CD79A, CD14, CD40LG
32	lactate32	7.2	VIM, CLU, BDNF, BCL6, CGB7, CD79A
33	doxorubicin32 34 9 9	10.1	VIM, CLU, BDNF, BCL6, UBE3A, CDKN1B
34	ly29400232	6.9	VEGFA, CD69, CDKN1B, CD44, IL10, IL4
35	paclitaxel32 34 9 9	9.7	VIM, VEGFA, CLU, BDNF, BCL2, CDKN1B
36	sb 20358032 42	7.5	VIM, VEGFA, BCL2, CDKN1B, ITGB1, IGF1
37	nitric oxide32 9 18 9	9.4	CNR2, SERPINB5, CISH, MUC1, S100A1, CD69
38	testosterone32 9 18 9	9.4	SERPINB5, VIM, CLU, PAX5, BDNF, MUC1
39	phosphatidylinositol32	6.3	BDNF, BCL2, CISH, CD69, CDKN1B, CD14
40	tyrosine32	6.2	PDCD1, CNR2, VEGFA, LILRB1, CLDN4, CLU
41	pd 98,05932	6.1	BDNF, BCL2, CD69, CDKN1B, CD14, CD40
42	butyrate32	6.1	VIM, CLU, BCL2, MUC1, CDKN1B, CD14
43	vegf32	6.1	SERPINB5, CLU, BDNF, BCL2, MUC1, CDKN1B
44	paraffin32	5.9	SERPINB5, VIM, VEGFA, CMA1, CLU, PAX5
45	cisplatin32 34 9 9	8.7	CNR2, SERPINB5, VEGFA, CLU, BDNF, BCL2
46	genistein32 9 18 9	7.7	VIM, VEGFA, BCL2, CD69, CDKN1B, CDKN2A
47	dexamethasone32 42 34 9 9	8.4	VIM, VEGFA, RAG1, CLDN4, CLU, BCL2
48	serine32	4.4	SERPINB5, VIM, RAG2, CMA1, CLDN4, CLU
49	actinomycin d32	4.2	VIM, VEGFA, CLU, BDNF, BCL2, MUC1
50	cycloheximide32	2.4	ZNF673, VIM, VEGFA, CLU, BDNF, BCL2

Cellular components related to tonsillitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin complex	GO:008305	10.1	ITGB7, ITGB1, ITGAE, ITGA5, ITGA3, ITGA1
2	endosome	GO:005768	9.4	TLR9, EGFR, NGF, NTRK1, CTSE, CCR5
3	membrane raft	GO:045121	8.8	DPP4, EGFR, EDNRA, KRAS, TNF, GJA1
4	extracellular region	GO:005576	8.6	PILRA, FDCSP, FCRLA, IL15, IL1A, IL2
5	external side of plasma membrane	GO:009897	8.4	ITGA1, ITGA5, ITGAE, ITGB1, IL12RB1, IL4
6	cell surface	GO:009986	8.4	CCR5, ALPP, TNF, NTRK1, NTRK2, DPP4
7	integral to plasma membrane	GO:005887	8.3	CYSLTR1, TMEM8A, TNF, GJA1, F2RL1, HTR3A
8	plasma membrane	GO:005886	6.8	TNF, TNFRSF8, CYSLTR1, NTF3, NTRK1, NOS3
9	extracellular space	GO:005615	6.1	CD40LG, CCL2, CCL24, CCL21, CCL13, IGFBP3

Biological processes related to tonsillitis according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	11.1	CYSLTR1, DEFB1, DEFB4A, CX3CR1, CXCL1, CXCL5
2	immune response	GO:006955	10.9	FASLG, TLR1, TLR10, DEFB1, DEFB4A, CX3CL1
3	cellular calcium ion homeostasis	GO:006874	10.7	CCL13, CCR1, CCL2, CCL7, CCL15, CCL8
4	positive regulation of inflammatory response	GO:050729	10.6	CX3CL1, TLR9, EDNRA, CCL24, IL33, IL2
5	lymph node development	GO:048535	10.6	CXCR5, CXCL13, LTA, IL15
6	integrin-mediated signaling pathway	GO:007229	10.5	HCK, ITGB7, ITGB1, ITGAE, ITGA5, ITGA3
7	elevation of cytosolic calcium ion concentration	GO:007204	10.5	CHRNA10, CXCR4, CXCL13, EDNRA, CYSLTR1, F2RL1
8	mechanoreceptor differentiation	GO:042490	10.5	NTRK2, NTRK1, NTF3, BDNF
9	chemokine-mediated signaling pathway	GO:070098	10.4	CX3CR1, CCR9, CCR1, CCR5, CCL2
10	positive regulation of angiogenesis	GO:045766	10.4	ECM1, CX3CR1, CX3CL1, NOS3, NTRK1, CCL24
11	negative regulation of interferon-gamma production	GO:032689	10.3	PGLYRP4, PGLYRP3, IL33, IL10, LILRB1
12	defense response to bacterium	GO:042742	10.3	DEFB103A, DEFB113, DEFB4A, CXCL13, HAMP, DEFB1
13	B cell differentiation	GO:030183	10.3	NTRK1, AICDA, IL4, IL10, ITGB1, CD40LG
14	regulation of immune response	GO:050776	10.3	ICAM1, IL4, ITGB7, ITGB1, CD40, CD40LG
15	cell-cell signaling	GO:007267	10.2	LHX1, CD70, CCL24, CCL21, CCL13, GJA1
16	innate immune response	GO:045087	10.2	TLR1, TLR10, TLR8, TLR9, DEFB1, DEFB103A
17	signal transduction	GO:007165	10.1	LTA, NTF3, SPARCL1, TNFRSF8, GJA1, ICOSLG
18	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	EDNRA, NTRK1, TNF, F2RL1, CCL21, CCR1
19	positive regulation of activated T cell proliferation	GO:042104	10.1	ICOSLG, IGF1, IL4, IL2, IL12RB1
20	positive regulation of isotype switching to IgG isotypes	GO:048304	10.0	IFNG, IL4, IL2, CD40
21	defense response to Gram-positive bacterium	GO:050830	10.0	PGLYRP4, PGLYRP3, HCK, LTA, TNF, MBL2
22	defense response to virus	GO:051607	10.0	TLR8, RNASEL, NLRC5, F2RL1, IFNG, CD40
23	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.9	ECM1, TLR9, TNF, GJA1, F2RL1, CCL21
24	regulation of cell shape	GO:008360	9.9	HCK, LST1, ICAM1, CCL13, CCL24, CCL2
25	B cell proliferation	GO:042100	9.9	IL10, CD40, CD40LG, CD79A, BCL2
26	cytokine-mediated signaling pathway	GO:019221	9.9	CX3CL1, HCK, KRAS, RNASEL, SP100, ICAM1
27	positive regulation of MHC class II biosynthetic process	GO:045348	9.8	IFNG, IL4, IL10, CD40LG
28	positive regulation of B cell proliferation	GO:030890	9.8	MIF, IL2, IL4, IL7, CD38, CD40
29	positive regulation of gene expression	GO:010628	9.8	CSF1, PRDM1, KRAS, NGF, NTRK2, GJA1
30	negative regulation of neuron apoptotic process	GO:043524	9.7	SOD1, KRAS, NGF, NTRK2, NTRK1, NTF3
31	positive regulation of cytokine secretion	GO:050715	9.7	TNF, IL1A, IL10, MIF, CD14, CLEC6A
32	positive regulation of JNK cascade	GO:046330	9.6	TLR9, TNF, F2RL1, CCL21, IL1A, CD27
33	virus-host interaction	GO:019048	9.6	TP53, SP100, KRT8, HCK, TFRC, CX3CR1
34	cell surface receptor signaling pathway	GO:007166	9.4	EGFR, IFNG, CCR1, CCR5, CCL2, IL2RA
35	cellular response to lipopolysaccharide	GO:071222	9.4	CX3CR1, NOS2, TNIP3, ICAM1, IFNG, CCR5
36	negative regulation of growth of symbiont in host	GO:044130	9.2	LTA, TNF, IFNG, MBL2, IL10
37	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.2	TLR9, KRAS, NTRK1, TNFRSF8, TNF, CAT
38	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	EFNA5, TP53, IGF1, MIF, ITGB1, ITGA5
39	humoral immune response	GO:006959	9.1	LY86, LTA, TNF, IFNG, CCL2, IL7
40	Ras protein signal transduction	GO:007265	9.0	CDKN2A, IGF1, TP53, NTRK1, NGF, KSR1
41	positive regulation of apoptotic process	GO:043065	8.8	SOD1, NOS3, TNFRSF8, TNF, TP53, IGFBP3
42	release of cytochrome c from mitochondria	GO:001836	8.7	TP73, TP53, CASP3, BCL2, CLU
43	inflammatory response	GO:006954	8.4	CNR2, CCR5, CCR1, CCL24, CCL21, CCL13
44	positive regulation of cell proliferation	GO:008284	8.4	EDNRA, EGFR, HCK, HCLS1, DPP4, CXCL5
45	negative regulation of cell proliferation	GO:008285	8.2	TP53, TNF, TNFRSF8, SRF, NTRK1, NOS3
46	response to drug	GO:042493	7.8	ICAM1, HMBS, TNF, NOS3, NGF, LTA
47	response to hypoxia	GO:001666	7.8	NOS2, NOS3, LTA, EDNRA, DPP4, CX3CL1
48	anti-apoptosis	GO:006916	7.8	IGF1, TNF, TERT, NOS3, NGF, SOD1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	IFNG, F2RL1, TP53, TP73, TNF, SRF
50	negative regulation of apoptotic process	GO:043066	7.3	CAT, TP53, TNF, EDNRA, EGFR, HCK

Molecular functions related to tonsillitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	10.9	CX3CL1, CXCL1, CXCL13, CXCL5, CXCL6, CCL13
2	neurotrophin binding	GO:043121	10.0	NTRK3, NTRK2, NTRK1
3	transmembrane signaling receptor activity	GO:004888	9.7	ICAM1, TNFRSF8, EGFR, TLR1, TLR10, IL1RAPL1
4	receptor binding	GO:005102	9.7	CAT, GJA1, NTF3, NOS2, LTA, DPP4
5	tumor necrosis factor receptor binding	GO:005164	9.5	TNF, FASLG, CD40LG, CD70, LTA
6	receptor activity	GO:004872	9.5	TLR8, TLR1, F2RL1, HTR3A, ICAM1, ANPEP
7	protease binding	GO:002020	8.7	ECM1, CSTA, DPP4, TNF, TP53, ITGB1
8	growth factor activity	GO:008083	8.6	CSF1, CXCL1, NGF, NTF3, IGF1, IL7
9	cytokine activity	GO:005125	8.1	VEGFA, IL36B, IL4, IL7, FASLG, IFNG
10	protein homodimerization activity	GO:042803	7.8	CTSE, NTRK1, NTRK2, CRP, NOS2, DPP4
11	protein binding	GO:005515	3.8	TERT, DDX42, OTUB1, SSX2B, SRF, SP100