MCID: TNS005
MIFTS: 62

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Summaries for Tonsillitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and arthritis. An important gene associated with Tonsillitis is TLR10 (toll-like receptor 10), and among its related pathways are Immune System and PEDF Induced Signaling. The drug ceftibuten dihydrate and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Tonsillitis (/ˌtɒnsəˈlaɪtɪs/ TON-sə-LEYE-tis) is inflammation of the tonsils most commonly caused... more...

Aliases & Classifications for Tonsillitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

tonsillitis 8 10 44 60
chronic tonsillitis 8 44 60
throat infection - tonsillitis 8
tonsillitis, nos 8


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Disease Ontology8 DOID:10456
MeSH34 D014069
ICD1025 J35.0

Related Diseases for Tonsillitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tonsillitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media30.5LACTB, CD79A, DEFB1
2arthritis30.3LACTB, IL1A, CXCL1, CXCL6, LTA
3leukemia30.2LTA, CD27, CD79A, CXCL1, IL1A, LACTB
4influenza30.2LTA, CD27, CD79A, LACTB
5pneumonia30.1LACTB, CXCL1, CD79A, DEFB4A, DEFB1, EDNRA
6tuberculosis30.0DEFB4A, CD79A, LACTB
7rheumatoid arthritis29.9LTA, CD27, CD79A, CXCL6, CXCL1, IL1A
8sarcoidosis29.9IL1A, CD27, LTA, DEFB4A, DEFB1
9psoriasis29.9DEFB4A, LTA, CXCL1, IL1A
10rhinitis29.9CD79A, EDNRA
11dermatitis29.9CD79A, IL1A
12acute leukemia29.9LACTB
13adenocarcinoma29.9MTA1, EDNRA
14meningitis29.7LACTB, CXCL1, CD79A
15atopic dermatitis29.7DEFB4A
16neutropenia29.7LACTB
17macroglobulinemia29.7CD79A
18cervical cancer29.7IL1A
19thyroiditis29.7CD79A
20tonsil cancer10.6
21pharyngitis10.6
22adenoiditis10.5
23sarcoma10.4
24dendritic cell sarcoma10.3
25cervicitis10.3
26follicular dendritic cell sarcoma10.3
27infectious mononucleosis10.3
28tongue cancer10.3
29plasmacytoma10.3
30nasopharyngitis10.3
31squamous cell carcinoma10.3
32syphilis10.3
33actinomycosis10.2
34extramedullary plasmacytoma10.2
35scarlet fever10.2
36myocarditis10.2
37secondary syphilis10.1
38acute myocarditis10.1
39mediastinitis10.1
40tonsillar fossa cancer10.0
41lemierre's syndrome10.0
42pericoronitis10.0
43bronchitis10.0
44primary syphilis10.0
45amyloidosis10.0
46fasciitis10.0
47lymphadenitis10.0
48lymphangioma10.0
49neurilemmoma10.0
50mucopolysaccharidosis ih10.0

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Clinical Features for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tonsillitis

Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Search CenterWatch for Tonsillitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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32MalaCards
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MalaCards organs/tissues related to Tonsillitis:

32
Tonsil, B cells, T cells, Testes, Endothelial, Lymph node, Tongue, Colon, Skin, Bone, Bone marrow, Liver, Brain, Myeloid, Salivary gland, Thyroid, Kidney, Smooth muscle, Trachea

Animal Models for Tonsillitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tonsillitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4ICOSLG, HLX, EDNRA, LTA, CD27, CD79A
2MP:000538712.3IL1A, SOD1, ICOSLG, EDNRA, DEFB103A, DEFB1

Publications for Tonsillitis

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50PubMed
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Articles related to Tonsillitis:

(show top 50)    (show all 779)
idTitleAuthorsYear
1
Prevalence of clarithromycin-resistant Helicobacter pylori in patients with chronic tonsillitis by allele-specific Scorpion real-time polymerase chain reaction assay. (23404672)
2013
2
Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. (23877488)
2013
3
Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. (24190760)
2013
4
Direct molecular detection of Mycobacterium tuberculosis suspected to be the specific infection in a case of recurrent tonsillitis. (23591525)
2013
5
Concurrent assay for four bacterial species including alloiococcus otitidis in middle ear, nasopharynx and tonsils of children with otitis media with effusion: a preliminary report. (22737288)
2012
6
A case of central nervous system lymphoma manifesting as multiple patchy white matter lesions with a past history of tonsil lymphoma. (23257636)
2012
7
Streptococcus pyogenes infection of tonsil explants is associated with a human I^-defensin 1 response from control but not recurrent acute tonsillitis patients. (22520386)
2012
8
Streptococcal tonsillitis as a cause of urticaria: tonsillitis and urticaria. (21982399)
2012
9
Tonsillitis, peritonsillar and lateral pharyngeal abscesses. (22503067)
2012
10
The role of the actinomyces in obstructive tonsillar hypertrophy and recurrent tonsillitis in pediatric population. (21227516)
2011
11
Leiomyosarcoma of the tonsil. (21729441)
2011
12
Tonsillectomy or adeno-tonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. (19160201)
2009
13
Investigation of oxidative stress in patients with chronic tonsillitis. (19111415)
2009
14
The quality of life after tonsillectomy in children with recurrent tonsillitis. (18922360)
2008
15
Tonsillitis. (18853890)
2008
16
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
17
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. (16698947)
2007
18
CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. (18000950)
2007
19
Investigation of the role of ribonuclease L gene in the response of tonsil tissues against viral infections]. (17205688)
2006
20
Secondary syphilis presenting as tonsillitis in three patients. (16556350)
2006
21
Severe acute tonsillitis caused by Rothia dentocariosa in a healthy child. (15876953)
2005
22
Effect of tonsillectomy on serum concentrations of interleukins and TNF-alpha in patients with chronic tonsillitis. (12232470)
2002
23
Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis. (12059880)
2002
24
Tonsillar and erythrocyte levels of superoxide dismutase in children with and without recurrent tonsillitis]. (11927098)
2002
25
Treatment of acute tonsillitis with a fixed-combination herbal preparation. (11185059)
2000
26
Viral causes of tonsillitis and fever unresponsive to antibiotic therapy. (9951987)
1999
27
Culture characterization of differentiated high endothelial venule cells from human tonsils. (10092069)
1999
28
Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. (9923873)
1999
29
Initial events in the pathogenesis of acute tonsillitis caused by Streptococcus pyogenes. (9804015)
1998
30
Cryptic tonsillitis. (8917152)
1996
31
Organic psychosis linked to chronic tonsillitis and subsequent encephalitis: a probable autoimmune process. (8871776)
1996
32
Otitis media: relationship to tonsillitis, sinusitis and atopic diseases. (8735409)
1996
33
Are recurrent and chronic tonsillitis different entities? An immunological study with specific markers of inflammatory stages. (9082752)
1996
34
In situ localization of Streptococcus pyogenes during acute tonsillitis: an immunocytochemical study with gold markers. (8973728)
1996
35
Azithromycin versus penicillin V in the treatment of paediatric patients with acute streptococcal pharyngitis/tonsillitis. Paediatric Azithromycin Study Group. (8922571)
1996
36
Tonsillar lymphocyte subsets in tonsillitis and hyperplasia. (7502889)
1995
37
Concomitant in vivo production of 19 different cytokines in human tonsils. (7821961)
1994
38
Diagnosis, antibiotic treatment and outcome of acute tonsillitis: report of a WHO Regional Office for Europe study in 17 European countries. (1459378)
1992
39
Expression of beta 1-integrins, H-CAM (CD44) and LECAM-1 in primary gastro-intestinal B-cell lymphomas as compared to the adhesion receptor profile of the gut-associated lymphoid system, tonsil and peripheral lymph node. (1720425)
1991
40
Actinomycotic tonsillitis with expectoration of sulfur granules. (2915675)
1989
41
Secondary syphilis of the tonsil. (2730419)
1989
42
Comparison of size of tonsils in children with recurrent tonsillitis and in controls. (2496863)
1989
43
Diagnosis of streptococcal tonsillitis in general practice by clinical assessment and by office culture of throat swabs on Streptocult. (3298068)
1987
44
Rapid office methods for the diagnosis of streptococcal tonsillitis--reliability and impact on patient management. (3671912)
1987
45
Lingual tonsillitis. (3749999)
1986
46
The presence of beta-lactamase-producing bacteria as a guideline in the management of children with recurrent tonsillitis. (6400716)
1984
47
The tonsils and pustulosis palmaris et plantaris as viewed against the genetic background. (6582760)
1983
48
Tonsil and pustulosis palmaris et plantaris. Mainly in respect of complement. (6582758)
1983
49
Surgery or radiotherapy for tonsil cancer? (13934296)
1963
50
Chart and Brief Notes of a Case of Cavernous Sinus Thrombosis following Left Tonsillitis in a Boy, aged 10; Fatal Termination in Eighteen Days. (19976872)
1913

Genetic Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Tonsillitis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1115.3EDNRA, DEFB1, DEFB4A, LTA, CD79A, CXCL1
2vegf4412.1EDNRA, LTA, CD79A, CXCL6, CXCL1, IL1A
3retinoic acid44 2413.0DEFB1, DEFB4A, LTA, CD79A, CXCL1, IL1A
4cysteine4412.0SOD1, EDNRA, DEFB4A, CD27, CD79A, CXCL1
5rantes4411.9IL1A, CXCL1, CXCL6, LTA, DEFB4A
6indomethacin44 59 28 1114.9SOD1, EDNRA, LTA, CD79A, IL1A
7cyclosporin a44 28 5913.9EDNRA, LTA, CD79A, CXCL1, IL1A
8progesterone44 59 28 11 2415.8IL1A, CXCL1, LTA, DEFB4A, MTA1
9h2o24411.8IL1A, CD79A, LTA, EDNRA, SOD1
10serine4411.5LTA, CXCL6, CXCL1, IL1A, LACTB
11steroid4411.5CXCL1, CD79A, LTA, DEFB4A, EDNRA
12histamine44 28 2413.5CXCL1, CD79A, DEFB4A, EDNRA
13endotoxin4411.5EDNRA, DEFB4A, CXCL1
14grobeta4411.5IL1A, CXCL1, CXCL6
15ciprofloxacin44 1112.5LACTB, IL1A, DEFB1
16enterotoxin4411.5EDNRA, LTA, CD79A
17groalpha4411.5IL1A, CXCL1, CXCL6
18sulfasalazine44 28 49 1114.5IL1A, CXCL1, CD79A
19ivig4411.4LTA, CD79A, IL1A
20neopterin4411.4IL1A, CD79A, LTA
21vitamin d4411.3EDNRA, LTA, CD79A
22estrogen4411.2DEFB4A, CD79A
23grogamma4411.2CXCL1, CXCL6
24vancomycin44 1112.2CD79A, LACTB
25acetylcholine44 49 28 11 2415.0EDNRA, LTA
26hbd24411.0DEFB4A, DEFB1
27toxin-14411.0LTA, EDNRA
28azithromycin44 1111.8CD79A, LACTB
29polycarbonate4410.6CXCL1, IL1A

GO Terms for genes affiliated with Tonsillitis

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16Gene Ontology
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Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.5IL1A, BPIFB6, BPIFB2, SOD1, SCGB1D4, DEFB103A
2Golgi lumenGO:00579611.1DEFB4A, DEFB1, DEFB103A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.9IL1A, CXCL1, CXCL6, DEFB4A, DEFB1, TLR10
2signal transductionGO:00716511.8ICOSLG, EDNRA, MTA1, LTA, CXCL6, CXCL1
3chemotaxisGO:00693511.4DEFB1, DEFB4A, CXCL6, CXCL1
4inflammatory responseGO:00695411.2TLR10, CXCL6, CXCL1, IL1A
5defense response to bacteriumGO:04274211.1DEFB4A, DEFB1, DEFB103A
6G-protein coupled receptor signaling pathwayGO:00718611.0CXCL1, DEFB4A, DEFB1, EDNRA
7response to copper ionGO:04668810.9IL1A, SOD1

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488811.1CD79A, CD27, TLR10

Products for genes affiliated with Tonsillitis

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  • Antibodies
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Sources for Tonsillitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet