MCID: TNS005
MIFTS: 57

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Summaries for Tonsillitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and sinusitis. An important gene associated with Tonsillitis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Prion diseases and Defensins. The drug ceftibuten dihydrate and the compounds ebselen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:66 Tonsillitis (/?t?ns??la?t?s/ TON-s?-LEYE-tis) is inflammation of the tonsils most commonly caused by... more...

Aliases & Classifications for Tonsillitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

tonsillitis 9 11 46 63
chronic tonsillitis 9 46 63
throat infection - tonsillitis 9
tonsillitis, nos 9


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Disease Ontology9 DOID:10456
MeSH36 D014069
ICD1026 J35.0

Related Diseases for Tonsillitis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Symptoms for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Tonsillitis

Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Search CenterWatch for Tonsillitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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34MalaCards
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MalaCards organs/tissues related to Tonsillitis:

34
Tonsil, B cells, T cells, Testes, Endothelial, Lymph node, Tongue, Colon, Skin, Bone marrow, Bone, Liver, Brain, Myeloid, Thyroid, Kidney, Trachea, Salivary gland, Smooth muscle

Animal Models for Tonsillitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Tonsillitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7LTA, CD79A, IL1A, SOD1, EDNRA
2MP:00053977.4EDNRA, SOD1, IL1A, CD79A, LTA
3MP:00053877.2LTA, CD79A, IL1A, SOD1, DEFB1, EDNRA

Publications for Tonsillitis

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53PubMed
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Articles related to Tonsillitis:

(show top 50)    (show all 771)
idTitleAuthorsYear
1
Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis. (23588893)
2013
2
N-acetyl-I^-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy. (23911049)
2013
3
Tonsillar hyperplasia and recurrent tonsillitis: clinical-histological correlation. (24141676)
2013
4
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
5
NUT midline carcinoma mimicking tonsillitis in an eight-year-old girl. (21922980)
2011
6
The role of the actinomyces in obstructive tonsillar hypertrophy and recurrent tonsillitis in pediatric population. (21227516)
2011
7
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
8
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
9
A primary antibiotic treatment for acute streptococcal tonsillitis? (19635264)
2009
10
Recurrent tonsillitis and tonsillectomy in juvenile idiopathic arthritis. (19579150)
2009
11
Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. (19285734)
2009
12
Torticollis with tonsillitis. Is imaging necessary? (21687001)
2009
13
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
14
Lymphocyte-white blood cell count ratio: a quickly available screening tool to differentiate acute purulent tonsillitis from glandular fever. (17224526)
2007
15
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. (16698947)
2007
16
Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report. (16325925)
2006
17
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
18
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
19
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
20
A 23-year-old man with chest pressure, pallor, tachypnea, and tonsillitis. (15834391)
2005
21
Tonsillitis. (16620431)
2005
22
Lymphoid progenitor cells in human tonsils. (12598913)
2003
23
A newly discovered function of palatine tonsils in immune defence: the expression of defensins. (12378798)
2002
24
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
25
Bilateral secondary syphilis of the tonsil. (10767935)
1999
26
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. (9655610)
1998
27
Haemophilus influenzae and Streptococcus pyogenes group A challenge induce a Th1 type of cytokine response in cells obtained from tonsillar hypertrophy and recurrent tonsillitis. (9519380)
1998
28
Comparison of solid and liquid forms of homeopathic remedies for tonsillitis. (10351119)
1998
29
Interaction between oral alpha-streptococci and group A streptococci in patients with tonsillitis. (9228858)
1997
30
In vitro cultured stromal cells from human tonsils display a distinct phenotype and induce B cell adhesion and proliferation. (8566062)
1996
31
Samuel--the boy with tonsillitis. A care study. (7620260)
1995
32
The significance of recurrent tonsillitis in sickle cell disease. (7923845)
1994
33
Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. (7805681)
1994
34
Streptococcal tonsillitis: failure of penicillin therapy]. (8009683)
1994
35
Interfering alpha-streptococci as a protection against recurrent streptococcal tonsillitis in children. (8436458)
1993
36
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. (8285040)
1993
37
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. (1456137)
1992
38
Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study. (1632187)
1992
39
Lingual tonsillitis. (1954500)
1991
40
Acute nonrheumatic perimyocarditis complicating streptococcal tonsillitis. (2070373)
1991
41
Acute tonsillitis in young men: etiological agents and their differentiation. (2543062)
1989
42
Actinomycotic tonsillitis with expectoration of sulfur granules. (2915675)
1989
43
Group A streptococcal tonsillitis: comparative evaluation of kits for rapid diagnosis. (16312287)
1989
44
Penicillin tolerance in beta-streptococci isolated from patients with tonsillitis. (3118452)
1987
45
Lingual tonsillitis. (3749999)
1986
46
Serum immunoglobulins in patients with chronic tonsillitis. (6512392)
1984
47
Immunohistological studies on tonsils with recurrent tonsillitis and focus-tonsil with pustulosis palmaris et plantaris. (6398610)
1984
48
Cloning of interleukin 2 mRNAs from human tonsils. (6312994)
1983
49
Secondary syphilis of the tonsils. (20993323)
1946
50
Bilateral Tuberculous Disease of Tonsils with Tuberculous Laryngitis. (19975187)
1911

Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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51PathCards, 31KEGG, 56Reactome, 54QIAGEN, 61Thomson Reuters
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Pathways related to Tonsillitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1A, SOD1
2
Show member pathways
9.5DEFB4A, DEFB1
39.3LTA, IL1A
4
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.8IL1A, DEFB4A, LTA
5
Show member pathways
8.5EDNRA, IL1A, LTA

Compounds for genes affiliated with Tonsillitis

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Sources:
46Novoseek, 25HMDB, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ebselen469.9IL1A, SOD1
2hbd2469.9DEFB1, DEFB4A
3hydroquinone46 2510.9IL1A, SOD1
4sulfasalazine30 46 52 1212.8IL1A, CD79A
5ciprofloxacin46 52 1211.8DEFB1, IL1A
6polymyxin b469.8IL1A, DEFB1
7sodium arsenite469.7IL1A, SOD1
8okt3469.7LTA, CD79A
9captopril46 62 52 30 1213.6CD79A, IL1A
10n(g)-nitro-l-arginine methyl ester469.6EDNRA, SOD1
11lipoteichoic acid469.6LTA, DEFB4A
12rotenone469.5IL1A, SOD1
13ascorbic acid46 2510.5SOD1, IL1A, CD79A
14toxin-1469.4LTA, EDNRA
15ivig469.4IL1A, LTA, CD79A
16neopterin469.4CD79A, LTA, IL1A
17hyaluronic acid46 2510.4IL1A, LTA, CD79A
18mannose469.4DEFB4A, CD79A, LTA
19il 10469.2IL1A, LTA
20mycophenolate mofetil46 52 1211.2CD79A, LTA
21formaldehyde46 2510.2IL1A, CD79A, EDNRA
22egcg469.1SOD1, EDNRA, IL1A
23prostacyclin469.1IL1A, SOD1, EDNRA
24enterotoxin469.1CD79A, EDNRA, LTA
25lactate469.1SOD1, CD79A, LTA
26prednisolone46 30 1211.1EDNRA, LTA, CD79A
27norepinephrine46 25 1211.0CD79A, EDNRA, IL1A
28histamine46 30 2511.0EDNRA, DEFB4A, CD79A
29glutamate468.9SOD1, CD79A, LTA, IL1A
30rantes468.8DEFB1, DEFB4A, LTA, IL1A
31creatinine468.8IL1A, CD79A, SOD1, EDNRA
32arginine468.7SOD1, IL1A, EDNRA, CD79A
33estradiol46 25 1210.7DEFB4A, LTA, EDNRA
34cysteine468.7EDNRA, SOD1, CD79A, DEFB4A
35arachidonic acid46 30 25 1211.6LTA, IL1A, EDNRA
36vitamin d468.6LTA, CD79A, IL1A, EDNRA
37acetylcholine46 52 30 25 1212.6EDNRA, CD79A, IL1A, LTA
38paraffin468.6EDNRA, DEFB4A, LTA, CD79A
39cyclosporin a46 30 6210.6IL1A, LTA, EDNRA, CD79A
40pge2468.6EDNRA, CD79A, IL1A, LTA
41steroid468.5EDNRA, DEFB4A, CD79A, LTA
42vegf468.5LTA, CD79A, EDNRA, IL1A
43estrogen468.5EDNRA, DEFB4A, LTA, CD79A
44nitric oxide46 25 1210.5SOD1, LTA, IL1A, EDNRA
45endotoxin468.4EDNRA, DEFB4A, LTA, IL1A
46retinoic acid46 259.4IL1A, LTA, DEFB1, DEFB4A, CD79A
47lipid468.2LTA, EDNRA, DEFB4A, SOD1
48indomethacin46 30 62 1211.2EDNRA, SOD1, IL1A, CD79A, LTA
49h2o2468.2CD79A, IL1A, EDNRA, SOD1, LTA
50dexamethasone46 52 30 1210.6EDNRA, DEFB4A, DEFB1, IL1A, CD79A, LTA

GO Terms for genes affiliated with Tonsillitis

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17Gene Ontology
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Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.5DEFB1, DEFB4A
2extracellular regionGO:0055768.3IL1A, SOD1, DEFB1, DEFB4A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:0466889.7SOD1, IL1A
2chemotaxisGO:0069359.5DEFB4A, DEFB1
3defense response to bacteriumGO:0427429.2DEFB1, DEFB4A
4regulation of blood pressureGO:0082179.1SOD1, EDNRA
5immune responseGO:0069559.0DEFB4A, DEFB1, IL1A
6G-protein coupled receptor signaling pathwayGO:0071868.7EDNRA, DEFB4A, DEFB1

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5IL1A, SOD1

Products for genes affiliated with Tonsillitis

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Sources for Tonsillitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet