MCID: TNS005
MIFTS: 57

Tonsillitis malady

Respiratory, Oral categories

Summaries for Tonsillitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to sinusitis and arthritis. An important gene associated with Tonsillitis is TLR10 (toll-like receptor 10), and among its related pathways are Immune System and PEDF Induced Signaling. The drug ceftibuten dihydrate and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, colon and kidney, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:64 Tonsillitis (/ˌtɒnsəˈlaɪtɪs/ TON-sə-LEYE-tis) is inflammation of the tonsils most commonly caused... more...

Aliases & Classifications for Tonsillitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Oral


Aliases & Descriptions:

tonsillitis 8 10 45 61
chronic tonsillitis 8 45 61
throat infection - tonsillitis 8
tonsillitis, nos 8


External Ids:

Disease Ontology8 DOID:10456
MeSH35 D014069
ICD1025 J35.0

Related Diseases for Tonsillitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1sinusitis30.5LACTB, CXCL6, CD79A, DEFB4A
2arthritis30.3LACTB, IL1A, CXCL1, CXCL6, LTA
3tuberculosis30.1DEFB4A, CD79A, LACTB
4acute leukemia30.0LACTB
5adenocarcinoma29.9MTA1, EDNRA
6nephritis29.7CD79A, LTA
7atopic dermatitis29.7DEFB4A
8macroglobulinemia29.7CD79A
9tonsil cancer10.7
10pharyngitis10.6
11follicular dendritic cell sarcoma10.3
12infectious mononucleosis10.3
13tongue cancer10.3
14squamous cell carcinoma10.3
15syphilis10.3
16actinomycosis10.3
17extramedullary plasmacytoma10.3
18variant creutzfeldt-jakob disease10.3
19scarlet fever10.2
20secondary syphilis10.2
21adenoiditis10.2
22lemierre's syndrome10.1
23acute myocarditis10.1
24sleep apnea10.1
25pericoronitis10.1
26primary syphilis10.1
27amyloidosis10.1
28prurigo nodularis10.1
29mucopolysaccharidosis ih10.1
30choristoma10.1
31asthma10.0TLR10, EDNRA, DEFB1, DEFB4A, CD79A, CXCL6
32sepsis10.0DEFB1, DEFB4A, LTA, CXCL6, CXCL1, IL1A
33ulcerative colitis10.0DEFB1, DEFB4A, LTA, CD79A, CXCL1, IL1A
34pneumonia10.0LACTB, CXCL1, CD79A, DEFB4A, DEFB1, EDNRA
35melanoma10.0EDNRA, MTA1, CD27, CXCL1, IL1A, LACTB
36rheumatoid arthritis10.0LTA, CD27, CD79A, CXCL6, CXCL1, IL1A
37leukemia10.0LTA, CD27, CD79A, CXCL1, IL1A, LACTB
38sarcoidosis10.0IL1A, CD27, LTA, DEFB4A, DEFB1
39osteoarthritis10.0IL1A, CXCL1, CXCL6, LTA, DEFB4A
40gastritis10.0DEFB1, DEFB4A, CD79A, CXCL1
41duodenal ulcer10.0DEFB1, DEFB4A, LTA, CXCL1
42influenza10.0LTA, CD27, CD79A, LACTB
43periodontitis10.0IL1A, LTA, DEFB4A, DEFB1
44psoriasis10.0DEFB4A, LTA, CXCL1, IL1A
45periodontal disease10.0IL1A, CD79A, DEFB4A, DEFB1
46septic shock10.0LACTB, IL1A, CXCL1, LTA
47cork-handlers' disease10.0SOD1, EDNRA, DEFB1, DEFB4A
48ovarian cancer10.0IL1A, CXCL1, MTA1, EDNRA
49inflammatory bowel disease10.0DEFB1, DEFB4A, LTA, CXCL1
50cystic fibrosis10.0LACTB, DEFB4A, DEFB1

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Clinical Features for Tonsillitis

Drugs & Therapeutics for Tonsillitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tonsillitis

Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Search CenterWatch for Tonsillitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Tonsillitis:

33
Bone marrow, Colon, Kidney, Thyroid, Skin, Tonsil, Myeloid, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Tonsillitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tonsillitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4ICOSLG, HLX, EDNRA, LTA, CD27, CD79A
2MP:000538712.3IL1A, SOD1, ICOSLG, EDNRA, DEFB103A, DEFB1

Publications for Tonsillitis

Sources:
51PubMed
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Articles related to Tonsillitis:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Cross-sectional survey: risk-averse French GPs use more rapid-antigen diagnostic tests in tonsillitis in children. (24163205)
2013
2
Prevalence of clarithromycin-resistant Helicobacter pylori in patients with chronic tonsillitis by allele-specific Scorpion real-time polymerase chain reaction assay. (23404672)
2013
3
Molecular mapping to species level of the tonsillar crypt microbiota associated with health and recurrent tonsillitis. (23437130)
2013
4
Comparison of clinical efficacy between 3-day combined clavulanate/amoxicillin preparation treatment and 10-day amoxicillin treatment in children with pharyngolaryngitis or tonsillitis. (22760341)
2013
5
Comparative study of bacterial strains and antibiotic susceptibility tests between chronic tonsillitis patients with IgA nephropathy and without nephritis. (24003909)
2013
6
Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis. (21937126)
2011
7
Are empiric antibiotics for acute exudative tonsillitis needed in children? (21524968)
2011
8
The correlation between EBV viral load in the palatine tonsils of patients with recurrent tonsillitis and concurrent serum titers of VCAa89IgG. (19437027)
2010
9
Torticollis with tonsillitis. Is imaging necessary? (21687001)
2009
10
Optimizing the management of the main acute infections in pediatric ORL: tonsillitis, sinusitis, otitis media. (19082359)
2008
11
Tonsillitis. (18853890)
2008
12
Proliferating active cells, lymphocyte subsets, and dendritic cells in recurrent tonsillitis: their effect on hypertrophy. (18490567)
2008
13
Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis. (17644191)
2007
14
Neuro-BehAsets/neuro-Sweets disease presents simultaneously with severe tonsillitis, and features mimicking bacterial meningitis with skin lesions. (17170507)
2006
15
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
16
Investigation of antioxidant status in children with acute otitis media and tonsillitis. (15488967)
2004
17
Rapid test, throat culture and clinical assessment in the diagnosis of tonsillitis. (12651781)
2003
18
Free radicals and scavenging enzymes in chronic tonsillitis. (12958578)
2003
19
Comparison of 5 days of extended-release clarithromycin versus 10 days of penicillin V for the treatment of streptococcal pharyngitis/tonsillitis: results of a multicenter, double-blind, randomized study in adolescent and adult patients. (13678479)
2003
20
Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis. (12059880)
2002
21
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
22
Is there agreement among general practitioners, paediatricians and otolaryngologists about the management of children with recurrent tonsillitis? (11678944)
2001
23
Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France. (11481304)
2001
24
SIgA- and IgG-coated Streptococcus pyogenes on the tonsillar surfaces during acute tonsillitis. (10587008)
1999
25
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. (9655610)
1998
26
Recurrent unilateral tonsillitis secondary to a penetrating foreign body in the tonsil. (9764305)
1998
27
Throat swabs in chronic tonsillitis: a time-honoured practice best forgotten. (9293052)
1997
28
Early adenotonsillectomy for relief of acute upper airway obstruction due to acute tonsillitis in children. (8882106)
1996
29
Are recurrent and chronic tonsillitis different entities? An immunological study with specific markers of inflammatory stages. (9082752)
1996
30
In situ localization of Streptococcus pyogenes during acute tonsillitis: an immunocytochemical study with gold markers. (8973728)
1996
31
Tuberculous tonsillitis. (8537992)
1995
32
Streptococcal tonsillitis: failure of penicillin therapy]. (8009683)
1994
33
Alpha-streptococci as supplementary treatment of recurrent streptococcal tonsillitis: a randomized placebo-controlled study. (8460346)
1993
34
Spontaneous tonsillar bleeding; secondary to acute tonsillitis in children. (8444561)
1993
35
The membranous tonsillitis during infectious mononucleosis is nevertheless of bacterial origin. (8444556)
1993
36
A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis. (8195854)
1993
37
Serum immunoglobulin E levels in children with chronic tonsillitis. (1428592)
1992
38
Acute nonrheumatic perimyocarditis complicating streptococcal tonsillitis. (2070373)
1991
39
Adverse effect of chronic tonsillitis on clinical course of sarcoidosis. (1669976)
1991
40
Phenoxymethyl-penicillin vs co-amoxyclav in acute recurrent tonsillitis. (2110940)
1990
41
Rapid development of cor pulmonale following acute tonsillitis in adults. (2914501)
1989
42
Low-dose ciprofloxacin in the treatment of bacterial pharyngo-tonsillitis. (16312625)
1989
43
Penicillin and clindamycin therapy in recurrent tonsillitis. Effect of microbial flora. (2500139)
1989
44
Spiramycin versus penicillin V in the empiric treatment of bacterial tonsillitis. (2514782)
1989
45
Beta-haemolytic streptococci group A in a cat, as a possible source of repeated tonsillitis in a family. (2903291)
1988
46
Experimental and clinical studies of causative bacteria in tonsillitis. (3066105)
1988
47
Adenoid infection: its relationship to otitis media, glue ear and tonsillitis. (3665135)
1987
48
Evaluation of beta-lactamase activity and microbial interference in treatment failures of acute streptococcal tonsillitis. (3094137)
1986
49
A summer-camp outbreak of beta hemolytic streptococcal tonsillitis. (3978530)
1985
50
THE ASSOCIATION OF SUSCEPTIBILITY TO SCARLET FEVER AND ACUTE TONSILLITIS. (18740662)
1928

Genetic Variations for Tonsillitis

Expression for genes affiliated with Tonsillitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

Sources:
54Reactome, 52QIAGEN, 30KEGG
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Compounds for genes affiliated with Tonsillitis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1115.3EDNRA, DEFB1, DEFB4A, LTA, CD79A, CXCL1
2vegf4512.1EDNRA, LTA, CD79A, CXCL6, CXCL1, IL1A
3retinoic acid45 2413.0DEFB1, DEFB4A, LTA, CD79A, CXCL1, IL1A
4cysteine4512.0SOD1, EDNRA, DEFB4A, CD27, CD79A, CXCL1
5rantes4511.9IL1A, CXCL1, CXCL6, LTA, DEFB4A
6indomethacin45 60 29 1114.9SOD1, EDNRA, LTA, CD79A, IL1A
7cyclosporin a45 29 6013.9EDNRA, LTA, CD79A, CXCL1, IL1A
8progesterone45 60 29 11 2415.8IL1A, CXCL1, LTA, DEFB4A, MTA1
9h2o24511.8IL1A, CD79A, LTA, EDNRA, SOD1
10serine4511.5LTA, CXCL6, CXCL1, IL1A, LACTB
11steroid4511.5CXCL1, CD79A, LTA, DEFB4A, EDNRA
12histamine45 29 2413.5CXCL1, CD79A, DEFB4A, EDNRA
13endotoxin4511.5EDNRA, DEFB4A, CXCL1
14grobeta4511.5IL1A, CXCL1, CXCL6
15ciprofloxacin45 1112.5LACTB, IL1A, DEFB1
16enterotoxin4511.5EDNRA, LTA, CD79A
17groalpha4511.5IL1A, CXCL1, CXCL6
18sulfasalazine45 29 50 1114.5IL1A, CXCL1, CD79A
19ivig4511.4LTA, CD79A, IL1A
20neopterin4511.4IL1A, CD79A, LTA
21vitamin d4511.3EDNRA, LTA, CD79A
22estrogen4511.2DEFB4A, CD79A
23grogamma4511.2CXCL1, CXCL6
24vancomycin45 1112.2CD79A, LACTB
25acetylcholine45 50 29 11 2415.0EDNRA, LTA
26hbd24511.0DEFB4A, DEFB1
27toxin-14511.0LTA, EDNRA
28azithromycin45 1111.8CD79A, LACTB
29polycarbonate4510.6CXCL1, IL1A

GO Terms for genes affiliated with Tonsillitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.5IL1A, BPIFB6, BPIFB2, SOD1, SCGB1D4, DEFB103A
2Golgi lumenGO:00579611.1DEFB4A, DEFB1, DEFB103A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.9IL1A, CXCL1, CXCL6, DEFB4A, DEFB1, TLR10
2signal transductionGO:00716511.8ICOSLG, EDNRA, MTA1, LTA, CXCL6, CXCL1
3chemotaxisGO:00693511.4DEFB1, DEFB4A, CXCL6, CXCL1
4inflammatory responseGO:00695411.2TLR10, CXCL6, CXCL1, IL1A
5defense response to bacteriumGO:04274211.1DEFB4A, DEFB1, DEFB103A
6G-protein coupled receptor signaling pathwayGO:00718611.0CXCL1, DEFB4A, DEFB1, EDNRA
7response to copper ionGO:04668810.9IL1A, SOD1

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488811.1CD79A, CD27, TLR10

Products for genes affiliated with Tonsillitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tonsillitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet