MCID: TNS005
MIFTS: 48

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Aliases & Classifications for Tonsillitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 25ICD10
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Aliases & Descriptions for Tonsillitis:

Name: Tonsillitis 8 10 44 61
Chronic Tonsillitis 8 44 61
 
Throat Infection - Tonsillitis 8
Tonsillitis, Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:10456
MeSH33 D014069
ICD1025 J35.0

Summaries for Tonsillitis

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Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards based summary: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and sinusitis. An important gene associated with Tonsillitis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Prion diseases and Defensins. The drug ceftibuten dihydrate and the compounds ebselen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:64 Tonsillitis (/?t?ns??la?t?s/ TON-s?-LEYE-tis) is inflammation of the tonsils most commonly caused by... more...

Related Diseases for Tonsillitis

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Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Symptoms for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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MalaCards organs/tissues related to Tonsillitis:

31
Tonsil, B cells, T cells, Lymph node, Testes, Endothelial, Neutrophil, Colon, Tongue, Skin, Bone marrow, Bone, Brain, Liver, Smooth muscle, Kidney, Thyroid, Salivary gland, Myeloid, Trachea

Animal Models for Tonsillitis or affiliated genes

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MGI Mouse Phenotypes related to Tonsillitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7LTA, CD79A, IL1A, SOD1, EDNRA
2MP:00053977.4EDNRA, SOD1, IL1A, CD79A, LTA
3MP:00053877.2LTA, CD79A, IL1A, SOD1, DEFB1, EDNRA

Publications for Tonsillitis

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Articles related to Tonsillitis:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
Nonadherence to guidelines for prescribing antibiotic therapy to patients with tonsillitis or pharyngotonsillitis: a cross-sectional study. (25876462)
2015
2
Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population. (25683590)
2015
3
Comment on: "Probiotics in addition to antibiotics for the treatment of acute tonsillitis: a randomized, placebo-controlled study". (25896859)
2015
4
Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis. (25876001)
2015
5
The impact of prior tonsillitis and treatment modality on the recurrence of peritonsillar abscess: a nationwide cohort study. (25291179)
2014
6
Comparative study of aerobic pathogenic bacteria isolates from patients with recurrent tonsillitis. (25358131)
2014
7
Patient-reported outcomes in children suffering with mild to moderate tonsillitis versus those in children with severe tonsillitis. (25338480)
2014
8
Syrinx resolution is correlated with the upward shifting of cerebellar tonsil following posterior fossa decompression in pediatric patients with Chiari malformation type I. (25408255)
2014
9
Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. (24816834)
2014
10
Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis. (23588893)
2013
11
N-acetyl-I^-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy. (23911049)
2013
12
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
13
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. (22406364)
2012
14
NUT midline carcinoma mimicking tonsillitis in an eight-year-old girl. (21922980)
2011
15
The role of the actinomyces in obstructive tonsillar hypertrophy and recurrent tonsillitis in pediatric population. (21227516)
2011
16
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
17
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
18
A primary antibiotic treatment for acute streptococcal tonsillitis? (19635264)
2009
19
Recurrent tonsillitis and tonsillectomy in juvenile idiopathic arthritis. (19579150)
2009
20
Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. (19285734)
2009
21
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
22
Lymphocyte-white blood cell count ratio: a quickly available screening tool to differentiate acute purulent tonsillitis from glandular fever. (17224526)
2007
23
Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report. (16325925)
2006
24
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
25
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
A 23-year-old man with chest pressure, pallor, tachypnea, and tonsillitis. (15834391)
2005
28
Tonsillitis. (16620431)
2005
29
Lymphoid progenitor cells in human tonsils. (12598913)
2003
30
A newly discovered function of palatine tonsils in immune defence: the expression of defensins. (12378798)
2002
31
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
32
Bilateral secondary syphilis of the tonsil. (10767935)
1999
33
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. (9655610)
1998
34
Interaction between oral alpha-streptococci and group A streptococci in patients with tonsillitis. (9228858)
1997
35
The significance of recurrent tonsillitis in sickle cell disease. (7923845)
1994
36
Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. (7805681)
1994
37
Streptococcal tonsillitis: failure of penicillin therapy]. (8009683)
1994
38
Interfering alpha-streptococci as a protection against recurrent streptococcal tonsillitis in children. (8436458)
1993
39
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. (8285040)
1993
40
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. (1456137)
1992
41
Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study. (1632187)
1992
42
Lingual tonsillitis. (1954500)
1991
43
Acute tonsillitis in young men: etiological agents and their differentiation. (2543062)
1989
44
Actinomycotic tonsillitis with expectoration of sulfur granules. (2915675)
1989
45
Group A streptococcal tonsillitis: comparative evaluation of kits for rapid diagnosis. (16312287)
1989
46
Lingual tonsillitis. (3749999)
1986
47
Serum immunoglobulins in patients with chronic tonsillitis. (6512392)
1984
48
Cloning of interleukin 2 mRNAs from human tonsils. (6312994)
1983
49
Secondary syphilis of the tonsils. (20993323)
1946
50
Bilateral Tuberculous Disease of Tonsils with Tuberculous Laryngitis. (19975187)
1911

Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SOD1, IL1A
2
Show member pathways
9.5DEFB1, DEFB4A
39.3LTA, IL1A
4
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.8LTA, IL1A, DEFB4A
5
Show member pathways
8.5LTA, IL1A, EDNRA

Compounds for genes affiliated with Tonsillitis

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Compounds related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ebselen449.9IL1A, SOD1
2hbd2449.9DEFB1, DEFB4A
3hydroquinone44 2410.9IL1A, SOD1
4sulfasalazine28 44 50 1112.8IL1A, CD79A
5ciprofloxacin44 50 1111.8DEFB1, IL1A
6polymyxin b449.8IL1A, DEFB1
7sodium arsenite449.7IL1A, SOD1
8okt3449.7LTA, CD79A
9captopril44 60 50 28 1113.6CD79A, IL1A
10n(g)-nitro-l-arginine methyl ester449.6EDNRA, SOD1
11lipoteichoic acid449.6LTA, DEFB4A
12rotenone449.5IL1A, SOD1
13ascorbic acid44 2410.5SOD1, IL1A, CD79A
14toxin-1449.4LTA, EDNRA
15ivig449.4IL1A, LTA, CD79A
16neopterin449.4CD79A, LTA, IL1A
17hyaluronic acid44 2410.4IL1A, LTA, CD79A
18mannose449.4DEFB4A, CD79A, LTA
19il 10449.2IL1A, LTA
20mycophenolate mofetil44 50 1111.2CD79A, LTA
21formaldehyde44 2410.2IL1A, CD79A, EDNRA
22egcg449.1SOD1, EDNRA, IL1A
23prostacyclin449.1IL1A, SOD1, EDNRA
24enterotoxin449.1CD79A, EDNRA, LTA
25lactate449.1SOD1, CD79A, LTA
26prednisolone44 28 1111.1EDNRA, LTA, CD79A
27norepinephrine44 24 1111.0CD79A, EDNRA, IL1A
28histamine44 28 2411.0EDNRA, DEFB4A, CD79A
29glutamate448.9SOD1, CD79A, LTA, IL1A
30rantes448.8DEFB1, DEFB4A, LTA, IL1A
31creatinine448.8IL1A, CD79A, SOD1, EDNRA
32arginine448.7SOD1, IL1A, EDNRA, CD79A
33estradiol44 24 1110.7DEFB4A, LTA, EDNRA
34cysteine448.7EDNRA, SOD1, CD79A, DEFB4A
35arachidonic acid44 28 24 1111.6LTA, IL1A, EDNRA
36vitamin d448.6LTA, CD79A, IL1A, EDNRA
37acetylcholine44 50 28 24 1112.6EDNRA, CD79A, IL1A, LTA
38paraffin448.6EDNRA, DEFB4A, LTA, CD79A
39cyclosporin a44 28 6010.6IL1A, LTA, EDNRA, CD79A
40pge2448.6EDNRA, CD79A, IL1A, LTA
41steroid448.5EDNRA, DEFB4A, CD79A, LTA
42vegf448.5LTA, CD79A, EDNRA, IL1A
43estrogen448.5EDNRA, DEFB4A, LTA, CD79A
44nitric oxide44 24 1110.5SOD1, LTA, IL1A, EDNRA
45endotoxin448.4EDNRA, DEFB4A, LTA, IL1A
46retinoic acid44 249.4IL1A, LTA, DEFB1, DEFB4A, CD79A
47lipid448.2LTA, EDNRA, DEFB4A, SOD1
48indomethacin44 28 60 1111.2EDNRA, SOD1, IL1A, CD79A, LTA
49h2o2448.2CD79A, IL1A, EDNRA, SOD1, LTA
50dexamethasone44 50 28 1110.6EDNRA, DEFB4A, DEFB1, IL1A, CD79A, LTA

GO Terms for genes affiliated with Tonsillitis

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Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.5DEFB1, DEFB4A
2extracellular regionGO:00055768.3IL1A, SOD1, DEFB1, DEFB4A

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:00466889.7IL1A, SOD1
2chemotaxisGO:00069359.5DEFB1, DEFB4A
3defense response to bacteriumGO:00427429.2DEFB1, DEFB4A
4regulation of blood pressureGO:00082179.1SOD1, EDNRA
5immune responseGO:00069559.0DEFB4A, DEFB1, IL1A
6G-protein coupled receptor signaling pathwayGO:00071868.7DEFB1, DEFB4A, EDNRA

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5IL1A, SOD1

Sources for Tonsillitis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet