MCID: TNS005
MIFTS: 57

Tonsillitis malady

Respiratory diseases, Oral diseases categories
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Summaries for Tonsillitis

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Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards based summary: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and sinusitis. An important gene associated with Tonsillitis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Prion diseases and Defensins. The drug ceftibuten dihydrate and the compounds ebselen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:65 Tonsillitis (/?t?ns??la?t?s/ TON-s?-LEYE-tis) is inflammation of the tonsils most commonly caused by... more...

Aliases & Classifications for Tonsillitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 25ICD10
See all sources

Tonsillitis, Aliases & Descriptions:

Name: Tonsillitis 8 10 44 62
Chronic Tonsillitis 8 44 62
 
Throat Infection - Tonsillitis 8
Tonsillitis, Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:10456
MeSH34 D014069
ICD1025 J35.0

Related Diseases for Tonsillitis

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Diseases related to Tonsillitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media31.0DEFB1, CD79A
2sinusitis30.9CD79A, DEFB4A
3tuberculosis30.5CD79A, DEFB4A
4dermatitis30.3CD79A, IL1A
5psoriasis30.2LTA, IL1A, DEFB4A
6rhinitis30.1CD79A, EDNRA
7diphtheria30.1CD79A, EDNRA
8nephritis30.0CD79A, LTA
9rheumatoid arthritis29.8IL1A, CD79A, LTA
10pneumonia29.7EDNRA, DEFB4A, DEFB1, CD79A
11atopic dermatitis29.7LTA, IL1A, DEFB4A
12sarcoidosis29.6DEFB4A, DEFB1, IL1A, LTA
13tonsil cancer10.7
14pharyngitis10.7
15adenoiditis10.5
16urethritis10.5CD79A
17cryptosporidiosis10.5CD79A
18periodontitis10.4IL1A
19sarcoma10.4
20oral candidiasis10.4DEFB4A
21pustulosis palmaris et plantaris10.4
22dendritic cell sarcoma10.4
23cervicitis10.4
24follicular dendritic cell sarcoma10.3
25infectious mononucleosis10.3
26plasmacytoma10.3
27nasopharyngitis10.3
28syphilis10.3
29blindness10.3
30endotheliitis10.3
31impetigo10.3EDNRA
32tonsil squamous cell carcinoma10.3
33variant creutzfeldt-jakob disease10.3
34creutzfeldt-jakob disease10.3
35actinomycosis10.3
36extramedullary plasmacytoma10.3
37tongue cancer10.3
38candidiasis10.3CD79A, DEFB4A
39arthritis10.2
40scarlet fever10.2
41myocarditis10.2
42schistosomiasis10.2IL1A, CD79A
43selective iga deficiency disease10.2LTA, CD79A
44bruton-type agammaglobulinemia10.2LTA, CD79A
45shigellosis10.2CD79A, LTA
46leukemia10.2
47secondary syphilis10.2
48influenza10.2
49chiari malformation10.2
50haemophilus influenzae10.2

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Symptoms for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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MalaCards organs/tissues related to Tonsillitis:

32
Tonsil, B cells, T cells, Testes, Lymph node, Endothelial, Tongue, Neutrophil, Colon, Skin, Bone marrow, Bone, Brain, Liver, Smooth muscle, Thyroid, Salivary gland, Myeloid, Trachea

Animal Models for Tonsillitis or affiliated genes

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MGI Mouse Phenotypes related to Tonsillitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7LTA, CD79A, IL1A, SOD1, EDNRA
2MP:00053977.4EDNRA, SOD1, IL1A, CD79A, LTA
3MP:00053877.2LTA, CD79A, IL1A, SOD1, DEFB1, EDNRA

Publications for Tonsillitis

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Articles related to Tonsillitis:

(show top 50)    (show all 804)
idTitleAuthorsYear
1
The impact of prior tonsillitis and treatment modality on the recurrence of peritonsillar abscess: a nationwide cohort study. (25291179)
2014
2
Comparative study of aerobic pathogenic bacteria isolates from patients with recurrent tonsillitis. (25358131)
2014
3
Patient-reported outcomes in children suffering with mild to moderate tonsillitis versus those in children with severe tonsillitis. (25338480)
2014
4
Syrinx resolution is correlated with the upward shifting of cerebellar tonsil following posterior fossa decompression in pediatric patients with Chiari malformation type I. (25408255)
2014
5
Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. (24816834)
2014
6
Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis. (23588893)
2013
7
N-acetyl-I^-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy. (23911049)
2013
8
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
9
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. (22406364)
2012
10
NUT midline carcinoma mimicking tonsillitis in an eight-year-old girl. (21922980)
2011
11
The role of the actinomyces in obstructive tonsillar hypertrophy and recurrent tonsillitis in pediatric population. (21227516)
2011
12
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
13
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
14
A primary antibiotic treatment for acute streptococcal tonsillitis? (19635264)
2009
15
Recurrent tonsillitis and tonsillectomy in juvenile idiopathic arthritis. (19579150)
2009
16
Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. (19285734)
2009
17
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
18
Lymphocyte-white blood cell count ratio: a quickly available screening tool to differentiate acute purulent tonsillitis from glandular fever. (17224526)
2007
19
Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report. (16325925)
2006
20
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
21
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
22
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
23
A 23-year-old man with chest pressure, pallor, tachypnea, and tonsillitis. (15834391)
2005
24
Tonsillitis. (16620431)
2005
25
Lymphoid progenitor cells in human tonsils. (12598913)
2003
26
A newly discovered function of palatine tonsils in immune defence: the expression of defensins. (12378798)
2002
27
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
28
Bilateral secondary syphilis of the tonsil. (10767935)
1999
29
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. (9655610)
1998
30
Haemophilus influenzae and Streptococcus pyogenes group A challenge induce a Th1 type of cytokine response in cells obtained from tonsillar hypertrophy and recurrent tonsillitis. (9519380)
1998
31
Interaction between oral alpha-streptococci and group A streptococci in patients with tonsillitis. (9228858)
1997
32
Samuel--the boy with tonsillitis. A care study. (7620260)
1995
33
The significance of recurrent tonsillitis in sickle cell disease. (7923845)
1994
34
Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. (7805681)
1994
35
Streptococcal tonsillitis: failure of penicillin therapy]. (8009683)
1994
36
Interfering alpha-streptococci as a protection against recurrent streptococcal tonsillitis in children. (8436458)
1993
37
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. (8285040)
1993
38
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. (1456137)
1992
39
Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study. (1632187)
1992
40
Lingual tonsillitis. (1954500)
1991
41
Acute tonsillitis in young men: etiological agents and their differentiation. (2543062)
1989
42
Actinomycotic tonsillitis with expectoration of sulfur granules. (2915675)
1989
43
Group A streptococcal tonsillitis: comparative evaluation of kits for rapid diagnosis. (16312287)
1989
44
Penicillin tolerance in beta-streptococci isolated from patients with tonsillitis. (3118452)
1987
45
Lingual tonsillitis. (3749999)
1986
46
Serum immunoglobulins in patients with chronic tonsillitis. (6512392)
1984
47
Immunohistological studies on tonsils with recurrent tonsillitis and focus-tonsil with pustulosis palmaris et plantaris. (6398610)
1984
48
Cloning of interleukin 2 mRNAs from human tonsils. (6312994)
1983
49
Secondary syphilis of the tonsils. (20993323)
1946
50
Bilateral Tuberculous Disease of Tonsils with Tuberculous Laryngitis. (19975187)
1911

Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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Pathways related to Tonsillitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SOD1, IL1A
2
Show member pathways
9.5DEFB1, DEFB4A
39.3LTA, IL1A
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.8LTA, IL1A, DEFB4A
5
Show member pathways
8.5LTA, IL1A, EDNRA

Compounds for genes affiliated with Tonsillitis

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Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ebselen449.9IL1A, SOD1
2hbd2449.9DEFB4A, DEFB1
3hydroquinone44 2410.9IL1A, SOD1
4sulfasalazine28 44 50 1112.8IL1A, CD79A
5ciprofloxacin44 50 1111.8IL1A, DEFB1
6polymyxin b449.8IL1A, DEFB1
7sodium arsenite449.7IL1A, SOD1
8okt3449.7LTA, CD79A
9captopril44 61 50 28 1113.6IL1A, CD79A
10n(g)-nitro-l-arginine methyl ester449.6SOD1, EDNRA
11lipoteichoic acid449.6DEFB4A, LTA
12rotenone449.5IL1A, SOD1
13ascorbic acid44 2410.5SOD1, IL1A, CD79A
14toxin-1449.4EDNRA, LTA
15ivig449.4LTA, CD79A, IL1A
16neopterin449.4LTA, CD79A, IL1A
17hyaluronic acid44 2410.4IL1A, CD79A, LTA
18mannose449.4LTA, CD79A, DEFB4A
19il 10449.2IL1A, LTA
20mycophenolate mofetil44 50 1111.2CD79A, LTA
21formaldehyde44 2410.2CD79A, IL1A, EDNRA
22egcg449.1IL1A, SOD1, EDNRA
23prostacyclin449.1IL1A, SOD1, EDNRA
24enterotoxin449.1EDNRA, CD79A, LTA
25lactate449.1LTA, CD79A, SOD1
26prednisolone44 28 1111.1LTA, CD79A, EDNRA
27norepinephrine44 24 1111.0EDNRA, IL1A, CD79A
28histamine44 28 2411.0EDNRA, DEFB4A, CD79A
29glutamate448.9SOD1, IL1A, CD79A, LTA
30rantes448.8LTA, IL1A, DEFB1, DEFB4A
31creatinine448.8EDNRA, SOD1, IL1A, CD79A
32arginine448.7CD79A, IL1A, SOD1, EDNRA
33estradiol44 24 1110.7EDNRA, DEFB4A, LTA
34cysteine448.7EDNRA, DEFB4A, SOD1, CD79A
35arachidonic acid44 28 24 1111.6LTA, IL1A, EDNRA
36vitamin d448.6EDNRA, IL1A, CD79A, LTA
37acetylcholine44 50 28 24 1112.6EDNRA, IL1A, CD79A, LTA
38paraffin448.6EDNRA, DEFB4A, CD79A, LTA
39cyclosporin a44 28 6110.6EDNRA, IL1A, CD79A, LTA
40pge2448.6LTA, CD79A, IL1A, EDNRA
41steroid448.5EDNRA, DEFB4A, CD79A, LTA
42vegf448.5EDNRA, IL1A, CD79A, LTA
43estrogen448.5LTA, CD79A, DEFB4A, EDNRA
44nitric oxide44 24 1110.5EDNRA, SOD1, IL1A, LTA
45endotoxin448.4LTA, IL1A, DEFB4A, EDNRA
46retinoic acid44 249.4DEFB4A, DEFB1, IL1A, CD79A, LTA
47lipid448.2LTA, SOD1, DEFB4A, EDNRA
48indomethacin44 28 61 1111.2EDNRA, SOD1, IL1A, CD79A, LTA
49h2o2448.2EDNRA, SOD1, IL1A, CD79A, LTA
50dexamethasone44 50 28 1110.6LTA, CD79A, IL1A, DEFB1, DEFB4A, EDNRA

GO Terms for genes affiliated with Tonsillitis

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Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.5DEFB1, DEFB4A
2extracellular regionGO:0055768.3IL1A, SOD1, DEFB1, DEFB4A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:0466889.7IL1A, SOD1
2chemotaxisGO:0069359.5DEFB1, DEFB4A
3defense response to bacteriumGO:0427429.2DEFB1, DEFB4A
4regulation of blood pressureGO:0082179.1SOD1, EDNRA
5immune responseGO:0069559.0DEFB4A, DEFB1, IL1A
6G-protein coupled receptor signaling pathwayGO:0071868.7DEFB1, DEFB4A, EDNRA

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5IL1A, SOD1

Products for genes affiliated with Tonsillitis

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Sources for Tonsillitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet