MCID: TNS005
MIFTS: 62

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Summaries for Tonsillitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and arthritis. An important gene associated with Tonsillitis is TLR10 (toll-like receptor 10), and among its related pathways are Immune System and PEDF Induced Signaling. The drug ceftibuten dihydrate and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Tonsillitis (/ˌtɒnsəˈlaɪtɪs/ TON-sə-LEYE-tis) is inflammation of the tonsils most commonly caused... more...

Aliases & Classifications for Tonsillitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

tonsillitis 8 10 44 60
chronic tonsillitis 8 44 60
throat infection - tonsillitis 8
tonsillitis, nos 8


External Ids:

Disease Ontology8 DOID:10456
MeSH34 D014069
ICD1025 J35.0

Related Diseases for Tonsillitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media30.5LACTB, CD79A, DEFB1
2arthritis30.3LACTB, IL1A, CXCL1, CXCL6, LTA
3leukemia30.2LTA, CD27, CD79A, CXCL1, IL1A, LACTB
4influenza30.2LTA, CD27, CD79A, LACTB
5pneumonia30.1LACTB, CXCL1, CD79A, DEFB4A, DEFB1, EDNRA
6tuberculosis30.0DEFB4A, CD79A, LACTB
7rheumatoid arthritis29.9LTA, CD27, CD79A, CXCL6, CXCL1, IL1A
8sarcoidosis29.9IL1A, CD27, LTA, DEFB4A, DEFB1
9psoriasis29.9DEFB4A, LTA, CXCL1, IL1A
10rhinitis29.9CD79A, EDNRA
11dermatitis29.9CD79A, IL1A
12acute leukemia29.9LACTB
13adenocarcinoma29.9MTA1, EDNRA
14meningitis29.7LACTB, CXCL1, CD79A
15atopic dermatitis29.7DEFB4A
16neutropenia29.7LACTB
17macroglobulinemia29.7CD79A
18cervical cancer29.7IL1A
19thyroiditis29.7CD79A
20tonsil cancer10.6
21pharyngitis10.6
22adenoiditis10.5
23sarcoma10.4
24dendritic cell sarcoma10.3
25cervicitis10.3
26follicular dendritic cell sarcoma10.3
27infectious mononucleosis10.3
28tongue cancer10.3
29plasmacytoma10.3
30nasopharyngitis10.3
31squamous cell carcinoma10.3
32syphilis10.3
33actinomycosis10.2
34extramedullary plasmacytoma10.2
35scarlet fever10.2
36myocarditis10.2
37secondary syphilis10.1
38acute myocarditis10.1
39mediastinitis10.1
40tonsillar fossa cancer10.0
41lemierre's syndrome10.0
42pericoronitis10.0
43bronchitis10.0
44primary syphilis10.0
45amyloidosis10.0
46fasciitis10.0
47lymphadenitis10.0
48lymphangioma10.0
49neurilemmoma10.0
50mucopolysaccharidosis ih10.0

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Clinical Features for Tonsillitis

About this section

Drugs & Therapeutics for Tonsillitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tonsillitis

Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Search CenterWatch for Tonsillitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tonsillitis

About this section

Anatomical Context for Tonsillitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Tonsillitis:

32
Tonsil, B cells, T cells, Testes, Lymph node, Endothelial, Tongue, Colon, Bone marrow, Bone, Skin, Brain, Liver, Salivary gland, Smooth muscle, Myeloid, Thyroid, Kidney, Trachea

Animal Models for Tonsillitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Tonsillitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4ICOSLG, HLX, EDNRA, LTA, CD27, CD79A
2MP:000538712.3IL1A, SOD1, ICOSLG, EDNRA, DEFB103A, DEFB1

Publications for Tonsillitis

About this section
Sources:
50PubMed
See all sources

Articles related to Tonsillitis:

(show top 50)    (show all 779)
idTitleAuthorsYear
1
Extent of local invasion and safe resection in cT1-2 tonsil cancer. (23129069)
2013
2
Benign mass in tonsil- cavernous hemangioma. (24298502)
2013
3
Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome. (23864246)
2013
4
Clinical significance and diagnostic usefulness of serologic markers for improvement of outcome of tonsillectomy in adults with chronic tonsillitis. (23816317)
2013
5
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
6
Basaloid squamous cell carcinoma of the tonsil. (23930063)
2012
7
Syphilitic tonsillitis in primary care: a case report. (22520907)
2012
8
Cervical lymph node metastasis of extramedullary plasmacytoma of the tonsil presenting with granulomatous lymphadenitis in fine needle aspiration cytology. (20968166)
2010
9
Trends in the incidence rates of tonsil and base of tongue cancer in England, 1985-2006. (20615309)
2010
10
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
11
Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. (17657785)
2008
12
Killer cell immunoglobulin-like receptor (KIR) genotypes in patients with recurrent tonsillitis. (19072563)
2008
13
Recurrent pharyngo-tonsillitis. (17478789)
2007
14
Powered intracapsular tonsillectomy in the management of recurrent tonsillitis. (17666267)
2007
15
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
16
Heritability of recurrent tonsillitis. (15897415)
2005
17
Re: Cytogenetic biomonitoring in children with chronic tonsillitis. (16219365)
2005
18
Histopathological evaluation in biopsies of palatine tonsils submitted to cryptolysis by coagulation with CO2 laser for treatment of chronic caseous tonsillitis. (15315728)
2004
19
Tonsil with Tangier disease. (12696235)
2003
20
Decreased serum and pharyngeal antibody levels specific to streptococcal lipoteichoic acid in children with recurrent tonsillitis. (11997155)
2002
21
Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils. (11781235)
2002
22
Expression of macrophage inflammatory protein-3alpha, stromal cell-derived factor-1, and B-cell-attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells. (11389046)
2001
23
Throat swab in the chronic tonsillitis: how reliable and valid is it? (11026798)
2000
24
The tonsils and adenoids as a site of infection and the cause of obstruction]. (9866845)
1998
25
Tonsillitis: its causes, management and possible complications. (9536597)
1997
26
6-day amoxicillin versus 10-day penicillin V for group A beta-haemolytic streptococcal acute tonsillitis in adults: a French multicentre, open-label, randomized study. The French Study Group Clamorange. (8953681)
1996
27
Histopathological concept of chronic tonsillitis in children. (9082761)
1996
28
Systemic immune response to Streptococcal and Staphylococcal lipoteichoic acids in children with recurrent tonsillitis. (9082751)
1996
29
Cefetamet pivoxil in the treatment of pharyngitis/tonsillitis in children and adults. (7518764)
1994
30
Acute rheumatic fever despite clarithromycin treatment of beta-hemolytic streptococcal tonsillitis. (7841580)
1994
31
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. (8285040)
1993
32
Loracarbef versus penicillin V in the treatment of streptococcal pharyngitis and tonsillitis. (1428189)
1992
33
Loracarbef (LY163892) vs. penicillin VK in the treatment of streptococcal pharyngitis and tonsillitis. (1513608)
1992
34
In vivo attachment of group A streptococci to tonsillar epithelium during acute tonsillitis. (1909050)
1991
35
Fusobacterium pyomyositis of the shoulder after tonsillitis. Report of a case of Lemierre's syndrome. (1767655)
1991
36
Immunomodulatory effects of laser therapy in the treatment of chronic tonsillitis. (1837653)
1991
37
Immunohistological study on human palatine tonsils in cases with pustulosis palmaris et plantaris--the quantitative study by image analyzer]. (2181093)
1990
38
Effect of amoxycillin/clavulanic acid on the aerobic and anaerobic tonsillar microflora in the treatment of recurrent tonsillitis. (2284575)
1990
39
Rapid development of cor pulmonale following acute tonsillitis in adults. (2914501)
1989
40
Toxoplasmosis among cases of chronic tonsillitis. (2651540)
1989
41
Tonsillar penetration of erythromycin and its 2'-acetyl ester in patients with chronic tonsillitis. (3391878)
1988
42
Recurrent tonsillitis and growth in children. (3209364)
1988
43
Immunohistological studies on tonsils of recurrent tonsillitis and tonsils with focal infections. (3223270)
1988
44
Adenoid infection: its relationship to otitis media, glue ear and tonsillitis. (3665135)
1987
45
Clinical and laboratory findings in patients with acute tonsillitis. (3314320)
1987
46
Double-blind comparison of spiramycin and phenoxymethylpenicillin in treatment of upper respiratory tract infections (tonsillitis and rhinosinusitis). (3151348)
1987
47
Tonsillitis and rash associated with Corynebacterium haemolyticum. (3782868)
1986
48
A summer-camp outbreak of beta hemolytic streptococcal tonsillitis. (3978530)
1985
49
The diagnostic value of symptoms and signs in acute tonsillitis in children over the age of 10 and in adults. (4059866)
1985
50
Cervical lymph node tuberculosis and the tonsils. (18143046)
1949

Genetic Variations for Tonsillitis

About this section

Expression for genes affiliated with Tonsillitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

About this section
Sources:
53Reactome, 51QIAGEN, 29KEGG
See all sources

Compounds for genes affiliated with Tonsillitis

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1115.3EDNRA, DEFB1, DEFB4A, LTA, CD79A, CXCL1
2vegf4412.1EDNRA, LTA, CD79A, CXCL6, CXCL1, IL1A
3retinoic acid44 2413.0DEFB1, DEFB4A, LTA, CD79A, CXCL1, IL1A
4cysteine4412.0SOD1, EDNRA, DEFB4A, CD27, CD79A, CXCL1
5rantes4411.9IL1A, CXCL1, CXCL6, LTA, DEFB4A
6indomethacin44 59 28 1114.9SOD1, EDNRA, LTA, CD79A, IL1A
7cyclosporin a44 28 5913.9EDNRA, LTA, CD79A, CXCL1, IL1A
8progesterone44 59 28 11 2415.8IL1A, CXCL1, LTA, DEFB4A, MTA1
9h2o24411.8IL1A, CD79A, LTA, EDNRA, SOD1
10serine4411.5LTA, CXCL6, CXCL1, IL1A, LACTB
11steroid4411.5CXCL1, CD79A, LTA, DEFB4A, EDNRA
12histamine44 28 2413.5CXCL1, CD79A, DEFB4A, EDNRA
13endotoxin4411.5EDNRA, DEFB4A, CXCL1
14grobeta4411.5IL1A, CXCL1, CXCL6
15ciprofloxacin44 1112.5LACTB, IL1A, DEFB1
16enterotoxin4411.5EDNRA, LTA, CD79A
17groalpha4411.5IL1A, CXCL1, CXCL6
18sulfasalazine44 28 49 1114.5IL1A, CXCL1, CD79A
19ivig4411.4LTA, CD79A, IL1A
20neopterin4411.4IL1A, CD79A, LTA
21vitamin d4411.3EDNRA, LTA, CD79A
22estrogen4411.2DEFB4A, CD79A
23grogamma4411.2CXCL1, CXCL6
24vancomycin44 1112.2CD79A, LACTB
25acetylcholine44 49 28 11 2415.0EDNRA, LTA
26hbd24411.0DEFB4A, DEFB1
27toxin-14411.0LTA, EDNRA
28azithromycin44 1111.8CD79A, LACTB
29polycarbonate4410.6CXCL1, IL1A

GO Terms for genes affiliated with Tonsillitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.5IL1A, BPIFB6, BPIFB2, SOD1, SCGB1D4, DEFB103A
2Golgi lumenGO:00579611.1DEFB4A, DEFB1, DEFB103A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.9IL1A, CXCL1, CXCL6, DEFB4A, DEFB1, TLR10
2signal transductionGO:00716511.8ICOSLG, EDNRA, MTA1, LTA, CXCL6, CXCL1
3chemotaxisGO:00693511.4DEFB1, DEFB4A, CXCL6, CXCL1
4inflammatory responseGO:00695411.2TLR10, CXCL6, CXCL1, IL1A
5defense response to bacteriumGO:04274211.1DEFB4A, DEFB1, DEFB103A
6G-protein coupled receptor signaling pathwayGO:00718611.0CXCL1, DEFB4A, DEFB1, EDNRA
7response to copper ionGO:04668810.9IL1A, SOD1

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488811.1CD79A, CD27, TLR10

Products for genes affiliated with Tonsillitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tonsillitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet