MCID: TNS005
MIFTS: 62

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Summaries for Tonsillitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and arthritis. An important gene associated with Tonsillitis is TLR10 (toll-like receptor 10), and among its related pathways are Immune System and PEDF Induced Signaling. The drug ceftibuten dihydrate and the compounds dexamethasone and vegf have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Tonsillitis (/ˌtɒnsəˈlaɪtɪs/ TON-sə-LEYE-tis) is inflammation of the tonsils most commonly caused... more...

Aliases & Classifications for Tonsillitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

tonsillitis 8 10 44 60
chronic tonsillitis 8 44 60
throat infection - tonsillitis 8
tonsillitis, nos 8


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Disease Ontology8 DOID:10456
MeSH34 D014069
ICD1025 J35.0

Related Diseases for Tonsillitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tonsillitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1otitis media30.5LACTB, CD79A, DEFB1
2arthritis30.3LACTB, IL1A, CXCL1, CXCL6, LTA
3leukemia30.2LTA, CD27, CD79A, CXCL1, IL1A, LACTB
4influenza30.2LTA, CD27, CD79A, LACTB
5pneumonia30.1LACTB, CXCL1, CD79A, DEFB4A, DEFB1, EDNRA
6tuberculosis30.0DEFB4A, CD79A, LACTB
7rheumatoid arthritis29.9LTA, CD27, CD79A, CXCL6, CXCL1, IL1A
8sarcoidosis29.9IL1A, CD27, LTA, DEFB4A, DEFB1
9psoriasis29.9DEFB4A, LTA, CXCL1, IL1A
10rhinitis29.9CD79A, EDNRA
11dermatitis29.9CD79A, IL1A
12acute leukemia29.9LACTB
13adenocarcinoma29.9MTA1, EDNRA
14meningitis29.7LACTB, CXCL1, CD79A
15atopic dermatitis29.7DEFB4A
16neutropenia29.7LACTB
17macroglobulinemia29.7CD79A
18cervical cancer29.7IL1A
19thyroiditis29.7CD79A
20tonsil cancer10.6
21pharyngitis10.6
22adenoiditis10.5
23sarcoma10.4
24dendritic cell sarcoma10.3
25cervicitis10.3
26follicular dendritic cell sarcoma10.3
27infectious mononucleosis10.3
28tongue cancer10.3
29plasmacytoma10.3
30nasopharyngitis10.3
31squamous cell carcinoma10.3
32syphilis10.3
33actinomycosis10.2
34extramedullary plasmacytoma10.2
35scarlet fever10.2
36myocarditis10.2
37secondary syphilis10.1
38acute myocarditis10.1
39mediastinitis10.1
40tonsillar fossa cancer10.0
41lemierre's syndrome10.0
42pericoronitis10.0
43bronchitis10.0
44primary syphilis10.0
45amyloidosis10.0
46fasciitis10.0
47lymphadenitis10.0
48lymphangioma10.0
49neurilemmoma10.0
50mucopolysaccharidosis ih10.0

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Clinical Features for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tonsillitis

Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Search CenterWatch for Tonsillitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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32MalaCards
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MalaCards organs/tissues related to Tonsillitis:

32
Tonsil, B cells, T cells, Testes, Endothelial, Lymph node, Tongue, Colon, Skin, Bone, Bone marrow, Liver, Brain, Myeloid, Salivary gland, Thyroid, Kidney, Smooth muscle, Trachea

Animal Models for Tonsillitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tonsillitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4ICOSLG, HLX, EDNRA, LTA, CD27, CD79A
2MP:000538712.3IL1A, SOD1, ICOSLG, EDNRA, DEFB103A, DEFB1

Publications for Tonsillitis

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50PubMed
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Articles related to Tonsillitis:

(show top 50)    (show all 779)
idTitleAuthorsYear
1
Tonsillitis with acute myeloid leukemia: a case series for caution. (23599112)
2013
2
Manganese-superoxide dismutase and glutathione peroxidase 1 polymorphisms in recurrent tonsillitis and tonsillar hypertrophy. (22704671)
2012
3
Vitamin D levels in children with recurrent tonsillitis. (21215466)
2011
4
Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. (21240515)
2011
5
Microarray analysis of tonsils in immunoglobulin A nephropathy patients. (20138841)
2010
6
In reference to bacteriological comparison of tonsil core in recurrent tonsillitis and tonsillar hypertrophy. (18425053)
2008
7
An investigation of the significance of Actinomycosis in tonsil disease. (17919741)
2007
8
Treatment of non-streptococcal tonsillitis with metronidazole. (15627449)
2005
9
Biologically active neutrophil chemokine pattern in tonsillitis. (15008987)
2004
10
Antigen-presenting cells in the hypertrophic pharyngeal tonsils: a histochemical, immunuhistochemical and ultrastructural study. (15736718)
2004
11
Comment on: comparison of 5 days of ER clarithromycin versus 10 days of penicillin V for the treatment of streptococcal pharyngitis/tonsillitis. (15119981)
2004
12
Is ipsilateral radiation for tonsil cancer with limited tongue extension or T2N1 tonsil cancer without tongue involvement appropriate? (12183007)
2002
13
Polymorphous low-grade adenocarcinoma of the tonsil: report of a case and review of the literature. (12239697)
2002
14
Changes in human lymphocyte subpopulations in tonsils and regional lymph nodes of human head and neck squamous carcinoma compared to control lymph nodes. (11316463)
2001
15
Efficacy of short-course therapy with the ketolide telithromycin compared with 10 days of penicillin V for the treatment of pharyngitis/tonsillitis. (11868759)
2001
16
The role of beta-lactamase producing bacteria and bacterial interference in streptococcal tonsillitis. (11397612)
2001
17
Detection of Arcanobacterium haemolyticum phospholipase D neutralizing antibodies in patients with acute tonsillitis]. (11550418)
2001
18
Acute tonsillitis complicated by retropharyngeal and thyroid abscess infected with de-repressed beta lactamase Citrobacter mutans. (11276343)
2001
19
Lymphocyte populations and adhesion molecule expression in bovine tonsils. (10678395)
2000
20
Activation of CD8 T cells normalizes and correlates with the level of infectious provirus in tonsils during highly active antiretroviral therapy in early HIV-1 infection. (10597778)
1999
21
Increased urinary excretion of macrophage-colony-stimulating factor (M-CSF) in patients with IgA nephropathy: tonsil stimulation enhances urinary M-CSF excretion. (10050079)
1999
22
Two cases of chronic tonsillitis studied by FDG-PET. (10510887)
1999
23
What is wrong in chronic adenoiditis/tonsillitis immunological factor. (10577792)
1999
24
Haemophilus influenzae and Streptococcus pyogenes group A challenge induce a Th1 type of cytokine response in cells obtained from tonsillar hypertrophy and recurrent tonsillitis. (9519380)
1998
25
Immunohistochemical study of tonsils from newborn infants with emphasis on follicular dendritic reticulum cells. (9857244)
1998
26
Bacteriology of normal and diseased tonsils assessed by fine-needle aspiration: Haemophilus influenzae and the pathogenesis of recurrent acute tonsillitis. (9597292)
1998
27
Interaction between oral alpha-streptococci and group A streptococci in patients with tonsillitis. (9228858)
1997
28
What you need to know: tonsillitis--medical and surgical therapy. (9529963)
1997
29
Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. (9217739)
1997
30
Chronic tonsillitis in children: activation of polymorphonuclear cells from peripheral blood and tonsillar tissue. In vitro production of MPO, ECP and EPX. (9082749)
1996
31
Tuberculous tonsillitis. (8537992)
1995
32
The lymphoepithelial organization of the tonsil: an immunohistochemical study in chronic recurrent tonsillitis. (7562254)
1995
33
Tissue-specific regulation of IL-4 mRNA expression in human tonsil. (7507959)
1994
34
Spontaneous tonsillar haemorrhage in acute tonsillitis. (7964148)
1994
35
Group F beta-hemolytic streptococcus, tonsillitis and myocarditis. (7747101)
1994
36
Tonsil cancer. Patterns of failure after surgery alone and surgery combined with postoperative radiation therapy. (8174064)
1994
37
Cervical necrotizing fasciitis and tonsillitis. (8035129)
1994
38
The treatment of recurrent tonsillitis with Broncasma Berna instead of tonsillectomy. (8457315)
1993
39
Recurrent tonsillitis. The role of Chlamydia and Mycoplasma. (1341878)
1992
40
Loracarbef versus penicillin VK in the treatment of streptococcal pharyngitis and tonsillitis in an adult population. (1621750)
1992
41
Management of tonsillitis by the general practitioner. (2391214)
1990
42
Acute tonsillitis in young men: etiological agents and their differentiation. (2543062)
1989
43
Group A streptococcal tonsillitis: comparative evaluation of kits for rapid diagnosis. (16312287)
1989
44
Effect of patients' expectations on recovery from acute tonsillitis. (2792618)
1989
45
Comparison of the microbiology of group A and non-group A streptococcal tonsillitis. (3132074)
1988
46
Cryptococcal tonsillitis in a patient with chronic lymphocytic leukemia: an unusual manifestation of cryptococcal disease. (3618590)
1987
47
Impact of phenoxymethylpenicillin and clindamycin on microflora in recurrent tonsillitis. (3925864)
1985
48
Serum immunoglobulins in patients with chronic tonsillitis. (6512392)
1984
49
Cor pulmonale as a result of chronic nasopharyngeal obstruction due to hypertrophied tonsils and adenoids. (4242077)
1969
50
THE ASSOCIATION OF SUSCEPTIBILITY TO SCARLET FEVER AND ACUTE TONSILLITIS. (18740662)
1928

Genetic Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Tonsillitis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1115.3EDNRA, DEFB1, DEFB4A, LTA, CD79A, CXCL1
2vegf4412.1EDNRA, LTA, CD79A, CXCL6, CXCL1, IL1A
3retinoic acid44 2413.0DEFB1, DEFB4A, LTA, CD79A, CXCL1, IL1A
4cysteine4412.0SOD1, EDNRA, DEFB4A, CD27, CD79A, CXCL1
5rantes4411.9IL1A, CXCL1, CXCL6, LTA, DEFB4A
6indomethacin44 59 28 1114.9SOD1, EDNRA, LTA, CD79A, IL1A
7cyclosporin a44 28 5913.9EDNRA, LTA, CD79A, CXCL1, IL1A
8progesterone44 59 28 11 2415.8IL1A, CXCL1, LTA, DEFB4A, MTA1
9h2o24411.8IL1A, CD79A, LTA, EDNRA, SOD1
10serine4411.5LTA, CXCL6, CXCL1, IL1A, LACTB
11steroid4411.5CXCL1, CD79A, LTA, DEFB4A, EDNRA
12histamine44 28 2413.5CXCL1, CD79A, DEFB4A, EDNRA
13endotoxin4411.5EDNRA, DEFB4A, CXCL1
14grobeta4411.5IL1A, CXCL1, CXCL6
15ciprofloxacin44 1112.5LACTB, IL1A, DEFB1
16enterotoxin4411.5EDNRA, LTA, CD79A
17groalpha4411.5IL1A, CXCL1, CXCL6
18sulfasalazine44 28 49 1114.5IL1A, CXCL1, CD79A
19ivig4411.4LTA, CD79A, IL1A
20neopterin4411.4IL1A, CD79A, LTA
21vitamin d4411.3EDNRA, LTA, CD79A
22estrogen4411.2DEFB4A, CD79A
23grogamma4411.2CXCL1, CXCL6
24vancomycin44 1112.2CD79A, LACTB
25acetylcholine44 49 28 11 2415.0EDNRA, LTA
26hbd24411.0DEFB4A, DEFB1
27toxin-14411.0LTA, EDNRA
28azithromycin44 1111.8CD79A, LACTB
29polycarbonate4410.6CXCL1, IL1A

GO Terms for genes affiliated with Tonsillitis

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16Gene Ontology
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Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.5IL1A, BPIFB6, BPIFB2, SOD1, SCGB1D4, DEFB103A
2Golgi lumenGO:00579611.1DEFB4A, DEFB1, DEFB103A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.9IL1A, CXCL1, CXCL6, DEFB4A, DEFB1, TLR10
2signal transductionGO:00716511.8ICOSLG, EDNRA, MTA1, LTA, CXCL6, CXCL1
3chemotaxisGO:00693511.4DEFB1, DEFB4A, CXCL6, CXCL1
4inflammatory responseGO:00695411.2TLR10, CXCL6, CXCL1, IL1A
5defense response to bacteriumGO:04274211.1DEFB4A, DEFB1, DEFB103A
6G-protein coupled receptor signaling pathwayGO:00718611.0CXCL1, DEFB4A, DEFB1, EDNRA
7response to copper ionGO:04668810.9IL1A, SOD1

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488811.1CD79A, CD27, TLR10

Products for genes affiliated with Tonsillitis

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  • Antibodies
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Sources for Tonsillitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet