MCID: TNS005
MIFTS: 56

Tonsillitis malady

Respiratory diseases, Oral diseases categories

Summaries for Tonsillitis

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Disease Ontology:10 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (group a streptococcus) and viral (epstein-barr virus, adenovirus) infections. symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). swelling of the cheeks and neck may occur.

MalaCards based summary: Tonsillitis, also known as chronic tonsillitis, is related to otitis media and sinusitis. An important gene associated with Tonsillitis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Prion diseases and Defensins. The drug ceftibuten dihydrate and the compounds ebselen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, b cells and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:65 Tonsillitis (/?t?ns??la?t?s/ TON-s?-LEYE-tis) is inflammation of the tonsils most commonly caused by... more...

Aliases & Classifications for Tonsillitis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH, 27ICD10
See all sources

Tonsillitis, Aliases & Descriptions:

Name: Tonsillitis 10 12 45 62
Chronic Tonsillitis 10 45 62
 
Throat Infection - Tonsillitis 10
Tonsillitis, Nos 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


External Ids:

Disease Ontology10 DOID:10456
MeSH35 D014069
ICD1027 J35.0

Related Diseases for Tonsillitis

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Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to tonsillitis

Symptoms for Tonsillitis

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Drugs & Therapeutics for Tonsillitis

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Drug clinical trials:

Search ClinicalTrials for Tonsillitis

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Tonsillitis

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Anatomical Context for Tonsillitis

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MalaCards organs/tissues related to Tonsillitis:

33
Tonsil, B cells, T cells, Lymph node, Testes, Endothelial, Neutrophil, Colon, Tongue, Skin, Bone marrow, Bone, Brain, Liver, Smooth muscle, Kidney, Thyroid, Salivary gland, Myeloid, Trachea

Animal Models for Tonsillitis or affiliated genes

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MGI Mouse Phenotypes related to Tonsillitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7LTA, CD79A, IL1A, SOD1, EDNRA
2MP:00053977.4EDNRA, SOD1, IL1A, CD79A, LTA
3MP:00053877.2LTA, CD79A, IL1A, SOD1, DEFB1, EDNRA

Publications for Tonsillitis

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Articles related to Tonsillitis:

(show top 50)    (show all 832)
idTitleAuthorsYear
1
Nonadherence to guidelines for prescribing antibiotic therapy to patients with tonsillitis or pharyngotonsillitis: a cross-sectional study. (25876462)
2015
2
Chronic tonsillitis is not associated with beta defensin 1 gene polymorphisms in Turkish population. (25683590)
2015
3
Comment on: "Probiotics in addition to antibiotics for the treatment of acute tonsillitis: a randomized, placebo-controlled study". (25896859)
2015
4
Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis. (25876001)
2015
5
The impact of prior tonsillitis and treatment modality on the recurrence of peritonsillar abscess: a nationwide cohort study. (25291179)
2014
6
Comparative study of aerobic pathogenic bacteria isolates from patients with recurrent tonsillitis. (25358131)
2014
7
Patient-reported outcomes in children suffering with mild to moderate tonsillitis versus those in children with severe tonsillitis. (25338480)
2014
8
Syrinx resolution is correlated with the upward shifting of cerebellar tonsil following posterior fossa decompression in pediatric patients with Chiari malformation type I. (25408255)
2014
9
Preoperative serum pattern analysis to predict the outcome of tonsillectomy in adults with chronic tonsillitis. (24816834)
2014
10
Penicillin failure in the treatment of streptococcal pharyngo-tonsillitis. (23588893)
2013
11
N-acetyl-I^-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy. (23911049)
2013
12
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
13
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. (22406364)
2012
14
NUT midline carcinoma mimicking tonsillitis in an eight-year-old girl. (21922980)
2011
15
The role of the actinomyces in obstructive tonsillar hypertrophy and recurrent tonsillitis in pediatric population. (21227516)
2011
16
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
17
Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. (19570691)
2009
18
A primary antibiotic treatment for acute streptococcal tonsillitis? (19635264)
2009
19
Recurrent tonsillitis and tonsillectomy in juvenile idiopathic arthritis. (19579150)
2009
20
Rate of eradication of group A beta-hemolytic streptococci in children with pharyngo-tonsillitis by amoxicillin and cefdinir. (19285734)
2009
21
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
22
Lymphocyte-white blood cell count ratio: a quickly available screening tool to differentiate acute purulent tonsillitis from glandular fever. (17224526)
2007
23
Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: a preliminary report. (16325925)
2006
24
Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study. (15885336)
2005
25
Report of an atypical case of leishmaniasis presented as acute tonsillitis in an immunocompetent patient. (16308231)
2005
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
A 23-year-old man with chest pressure, pallor, tachypnea, and tonsillitis. (15834391)
2005
28
Tonsillitis. (16620431)
2005
29
Lymphoid progenitor cells in human tonsils. (12598913)
2003
30
A newly discovered function of palatine tonsils in immune defence: the expression of defensins. (12378798)
2002
31
The management of severe infectious mononucleosis tonsillitis and upper airway obstruction. (11779326)
2001
32
Bilateral secondary syphilis of the tonsil. (10767935)
1999
33
Melatonin restores and enhances the human type B tonsillar lymphocyte subset in recurrent acute tonsillitis. (9655610)
1998
34
Interaction between oral alpha-streptococci and group A streptococci in patients with tonsillitis. (9228858)
1997
35
The significance of recurrent tonsillitis in sickle cell disease. (7923845)
1994
36
Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. (7805681)
1994
37
Streptococcal tonsillitis: failure of penicillin therapy]. (8009683)
1994
38
Interfering alpha-streptococci as a protection against recurrent streptococcal tonsillitis in children. (8436458)
1993
39
Chronic tonsillitis and IgA nephropathy. Clinical study of patients with and without tonsillectomy. (8285040)
1993
40
Immunohistochemical comparison between multinucleated giant cells which appear frequently in the tonsils of patients with pustulosis palmaris et plantaris and in other granulomatous inflammatory lesions. (1456137)
1992
41
Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study. (1632187)
1992
42
Lingual tonsillitis. (1954500)
1991
43
Acute tonsillitis in young men: etiological agents and their differentiation. (2543062)
1989
44
Actinomycotic tonsillitis with expectoration of sulfur granules. (2915675)
1989
45
Group A streptococcal tonsillitis: comparative evaluation of kits for rapid diagnosis. (16312287)
1989
46
Lingual tonsillitis. (3749999)
1986
47
Serum immunoglobulins in patients with chronic tonsillitis. (6512392)
1984
48
Cloning of interleukin 2 mRNAs from human tonsils. (6312994)
1983
49
Secondary syphilis of the tonsils. (20993323)
1946
50
Bilateral Tuberculous Disease of Tonsils with Tuberculous Laryngitis. (19975187)
1911

Variations for Tonsillitis

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Expression for genes affiliated with Tonsillitis

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Search GEO for disease gene expression data for Tonsillitis.

Pathways for genes affiliated with Tonsillitis

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Pathways related to Tonsillitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SOD1, IL1A
2
Show member pathways
9.5DEFB1, DEFB4A
39.3LTA, IL1A
4
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.8LTA, IL1A, DEFB4A
5
Show member pathways
8.5LTA, IL1A, EDNRA

Compounds for genes affiliated with Tonsillitis

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Compounds related to Tonsillitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1ebselen459.9IL1A, SOD1
2hbd2459.9DEFB4A, DEFB1
3hydroquinone45 2610.9IL1A, SOD1
4sulfasalazine30 45 51 1312.8IL1A, CD79A
5ciprofloxacin45 51 1311.8IL1A, DEFB1
6polymyxin b459.8IL1A, DEFB1
7sodium arsenite459.7IL1A, SOD1
8okt3459.7LTA, CD79A
9captopril45 61 51 30 1313.6IL1A, CD79A
10n(g)-nitro-l-arginine methyl ester459.6SOD1, EDNRA
11lipoteichoic acid459.6DEFB4A, LTA
12rotenone459.5IL1A, SOD1
13ascorbic acid45 2610.5SOD1, IL1A, CD79A
14toxin-1459.4EDNRA, LTA
15ivig459.4LTA, CD79A, IL1A
16neopterin459.4LTA, CD79A, IL1A
17hyaluronic acid45 2610.4IL1A, CD79A, LTA
18mannose459.4LTA, CD79A, DEFB4A
19il 10459.2IL1A, LTA
20mycophenolate mofetil45 51 1311.2CD79A, LTA
21formaldehyde45 2610.2CD79A, IL1A, EDNRA
22egcg459.1IL1A, SOD1, EDNRA
23prostacyclin459.1IL1A, SOD1, EDNRA
24enterotoxin459.1EDNRA, CD79A, LTA
25lactate459.1LTA, CD79A, SOD1
26prednisolone45 30 1311.1LTA, CD79A, EDNRA
27norepinephrine45 26 1311.0EDNRA, IL1A, CD79A
28histamine45 30 2611.0EDNRA, DEFB4A, CD79A
29glutamate458.9SOD1, IL1A, CD79A, LTA
30rantes458.8LTA, IL1A, DEFB1, DEFB4A
31creatinine458.8EDNRA, SOD1, IL1A, CD79A
32arginine458.7CD79A, IL1A, SOD1, EDNRA
33estradiol45 26 1310.7EDNRA, DEFB4A, LTA
34cysteine458.7EDNRA, DEFB4A, SOD1, CD79A
35arachidonic acid45 30 26 1311.6LTA, IL1A, EDNRA
36vitamin d458.6EDNRA, IL1A, CD79A, LTA
37acetylcholine45 51 30 26 1312.6EDNRA, IL1A, CD79A, LTA
38paraffin458.6EDNRA, DEFB4A, CD79A, LTA
39cyclosporin a45 30 6110.6EDNRA, IL1A, CD79A, LTA
40pge2458.6LTA, CD79A, IL1A, EDNRA
41steroid458.5EDNRA, DEFB4A, CD79A, LTA
42vegf458.5EDNRA, IL1A, CD79A, LTA
43estrogen458.5LTA, CD79A, DEFB4A, EDNRA
44nitric oxide45 26 1310.5EDNRA, SOD1, IL1A, LTA
45endotoxin458.4LTA, IL1A, DEFB4A, EDNRA
46retinoic acid45 269.4DEFB4A, DEFB1, IL1A, CD79A, LTA
47lipid458.2LTA, SOD1, DEFB4A, EDNRA
48indomethacin45 30 61 1311.2EDNRA, SOD1, IL1A, CD79A, LTA
49h2o2458.2EDNRA, SOD1, IL1A, CD79A, LTA
50dexamethasone45 51 30 1310.6LTA, CD79A, IL1A, DEFB1, DEFB4A, EDNRA

GO Terms for genes affiliated with Tonsillitis

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Cellular components related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.5DEFB1, DEFB4A
2extracellular regionGO:00055768.3IL1A, SOD1, DEFB1, DEFB4A

Biological processes related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:00466889.7IL1A, SOD1
2chemotaxisGO:00069359.5DEFB1, DEFB4A
3defense response to bacteriumGO:00427429.2DEFB1, DEFB4A
4regulation of blood pressureGO:00082179.1SOD1, EDNRA
5immune responseGO:00069559.0DEFB4A, DEFB1, IL1A
6G-protein coupled receptor signaling pathwayGO:00071868.7DEFB1, DEFB4A, EDNRA

Molecular functions related to Tonsillitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5IL1A, SOD1

Products for genes affiliated with Tonsillitis

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Sources for Tonsillitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet