MCID: TNS005
MIFTS: 56

Tonsillitis

Categories: Respiratory diseases, Oral diseases

Aliases & Classifications for Tonsillitis

MalaCards integrated aliases for Tonsillitis:

Name: Tonsillitis 12 52 41 42 14 69
Chronic Tonsillitis 12 52 69
Throat Infection - Tonsillitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10456
ICD10 33 J35.01 J35.0
ICD9CM 35 474.00
MeSH 42 D014069
NCIt 47 C116006

Summaries for Tonsillitis

MedlinePlus : 41 what are tonsils? tonsils are lumps of tissue at the back of the throat. there are two of them, one on each side. along with the adenoids, tonsils are part of the lymphatic system. the lymphatic system clears away infection and keeps body fluids in balance. tonsils and adenoids work by trapping the germs coming in through the mouth and nose. what is tonsillitis? tonsillitis is an inflammation (swelling) of the tonsils. sometimes along with tonsillitis, the adenoids are also swollen. what causes tonsillitis? the cause of tonsillitis is usually a viral infection. bacterial infections such as strep throat can also cause tonsillitis. who gets tonsillitis? tonsillitis is most common in children over age two. almost every child in the united states gets it at least once. tonsillitis caused by bacteria is more common in kids ages 5-15. tonsillitis caused by a virus is more common in younger children. adults can get tonsillitis, but it is not very common. is tonsillitis contagious? although tonsillitis is not contagious, the viruses and bacteria that cause it are contagious. frequent handwashing can help prevent spreading or catching the infections. what are the symptoms of tonsillitis? the symptoms of tonsillitis include a sore throat, which may be severe red, swollen tonsils trouble swallowing a white or yellow coating on the tonsils swollen glands in the neck fever bad breath when should i get medical help for my child? you should call your health care provider if your child has a sore throat for more than two days has trouble or pain when swallowing feels very sick or very weak you should get emergency care right away if your child has trouble breathing starts drooling has a lot of trouble swallowing how is tonsillitis diagnosed? to diagnose tonsillitis, your child's health care provider will first ask you about your child's symptoms and medical history. the provider will look at your child's throat and neck, checking for things such as redness or white spots on the tonsils and swollen lymph nodes. your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis and it requires treatment. it could be a rapid strep test, a throat culture, or both. for both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils and the back of the throat. with the rapid strep test, testing is done in the office, and you get the results within minutes. the throat culture is done in a lab, and it usually takes a few days to get the results. the throat culture is a more reliable test. so sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria), the provider will also do a throat culture just to make sure that your child does not have strep. what are the treatments for tonsillitis? treatment for tonsillitis depends on the cause. if the cause is a virus, there is no medicine to treat it. if the cause is a bacterial infection, such as strep throat, your child will need to take antibiotics. it is important for your child to finish the antibiotics even if he or she feels better. if treatment stops too soon, some bacteria may survive and re-infect your child. no matter what is causing the tonsillitis, there are some things you can do to help your child feel better. make sure that your child gets a lot of rest drinks plenty of fluids tries eating soft foods if it hurts to swallow tries eating warm liquids or cold foods like popsicles to soothe the throat isn't around cigarette smoke or do anything else that could irritate the throat sleeps in a room with a humidifier gargles with saltwater sucks on a lozenge (but do not give them to children under four; they can choke on them) takes an over-the-counter pain reliever such as acetaminophen. children and teenagers should not take aspirin. in some cases, your child may need a tonsillectomy. what is a tonsillectomy and why might my child need one? a tonsillectomy is surgery to remove the tonsils. your child might need it if he or she keeps getting tonsillitis has bacterial tonsillitis that does not get better with antibiotics has tonsils are too big, and are causing trouble breathing or swallowing your child usually gets the surgery and goes home later that day. very young children and people who have complications may need to stay in the hospital overnight. it can take a week or two before your child completely recovers from the surgery.

MalaCards based summary : Tonsillitis, also known as chronic tonsillitis, is related to sinusitis and toxoplasmosis, and has symptoms including sore throat An important gene associated with Tonsillitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cedax and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

Wikipedia : 72 Tonsillitis is inflammation of the tonsils, typically of rapid onset. It is a type of pharyngitis.... more...

Related Diseases for Tonsillitis

Diseases related to Tonsillitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 524)
id Related Disease Score Top Affiliating Genes
1 sinusitis 29.2 CXCL8 IL1A IL1B TNF
2 toxoplasmosis 28.8 IL6 LTA TNF
3 hemophagocytic lymphohistiocytosis 28.5 IFNG IL2 IL6 TNF
4 schneiderian carcinoma 27.6 IFNG IL1B IL6 TLR9 TNF
5 reticulosarcoma 27.2 CXCL8 IFNG IL1B IL6 TNF
6 lymphoma 26.8 CD79A IFNG IL1B IL2 IL4 IL6
7 rheumatoid arthritis 25.3 CD79A CXCL8 IFNG IL1A IL1B IL2
8 tonsil cancer 12.2
9 tonsil squamous cell carcinoma 12.2
10 tongue cancer 11.5
11 adenoid hypertrophy 11.4
12 chiari malformation 11.0
13 chiari malformation type i 11.0
14 sleep apnea 11.0
15 lemierre's syndrome 11.0
16 rheumatic fever 11.0
17 diphtheria 11.0
18 tangier disease 11.0
19 glossopharyngeal neuralgia 10.8
20 myoclonic astatic epilepsy 10.8 IFNG IL4
21 bulbospinal polio 10.8 IFNG IL2
22 kallmann syndrome 3 10.8 IL2 LTA
23 eye accommodation disease 10.7 IFNG IL4
24 anthracosilicosis 10.7 IFNG IL2
25 visual snow syndrome 10.7 IL2 IL4
26 oropharynx cancer 10.7
27 severe combined immunodeficiency, x-linked 10.7
28 pituitary hormone deficiency, combined, 4 10.7
29 megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 10.7
30 plague 10.7
31 c3 deficiency 10.7
32 graft-versus-host disease, protection against 10.7 IFNG IL2
33 scirrhous adenocarcinoma 10.6 IL2 TNF
34 thelaziasis 10.6 IFNG IL4
35 acute necrotizing encephalopathy type 1 10.6 IFNG IL2 TLR9
36 acute ackee fruit intoxication 10.6 IL4 TNF
37 dieulafoy lesion 10.6 IFNG IL4 TLR9
38 x-linked intellectual disability, van esch type 10.6 IFNG IL2 IL4
39 malignant renovascular hypertension 10.5 CD79A IFNG
40 congenital diaphragmatic hernia 10.5 CXCL8 IL2
41 lagophthalmos 10.5 IL4 TNF
42 mosaic trisomy 1 10.5 IFNG TNF
43 small intestine lymphoma 10.5 IL1A TNF
44 primary systemic mycosis 10.5 IFNG TNF
45 spondylocostal dysostosis 4 10.5 LTA TNF
46 type 1 papillary adenoma of the kidney 10.5 LTA TNF
47 pyridoxine-responsive sideroblastic anemia 10.5 IFNG IL2 IL4
48 goat milk allergy 10.5 IFNG IL4
49 lymph node palisaded myofibroblastoma 10.4 CXCL8 IL1A
50 autoimmune polyglandular syndrome type 3 10.4 IFNG IL2 TNF

Graphical network of the top 20 diseases related to Tonsillitis:



Diseases related to Tonsillitis

Symptoms & Phenotypes for Tonsillitis

UMLS symptoms related to Tonsillitis:


sore throat

GenomeRNAi Phenotypes related to Tonsillitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 IL1A IL1B IL2 LTA SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 IL1A IL1B IL2 LTA SOD1

MGI Mouse Phenotypes related to Tonsillitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CD79A IFNG IL1A IL1B IL2 IL4
2 homeostasis/metabolism MP:0005376 10.11 CD79A IFNG IL1A IL1B IL2 IL4
3 immune system MP:0005387 10.06 TLR9 TNF CD79A IFNG IL1A IL1B
4 cardiovascular system MP:0005385 10.03 TNF IFNG IL1A IL1B IL2 IL6
5 integument MP:0010771 9.8 IFNG IL1A IL1B IL4 IL6 SOD1
6 liver/biliary system MP:0005370 9.76 CD79A IFNG IL2 IL4 IL6 LTA
7 neoplasm MP:0002006 9.56 CD79A IFNG IL1A IL1B IL2 IL6
8 vision/eye MP:0005391 9.17 IFNG IL2 IL4 IL6 LTA SOD1

Drugs & Therapeutics for Tonsillitis

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cedax 17 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995

Drugs for Tonsillitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 169)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
3
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
7
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Codeine Approved, Illicit Phase 4 76-57-3 5284371
10
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
11
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
12
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
13
Clarithromycin Approved Phase 4,Phase 1 81103-11-9 84029
14
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
15
Penicillin V Approved, Vet_approved Phase 4,Phase 3 87-08-1 6869
16
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
17
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
18
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
19
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
20
Ibuprofen Approved Phase 4 15687-27-1 3672
21 Tinoridine Investigational Phase 4 24237-54-5
22 Andrographolide Investigational Phase 4 5508-58-7
23 Adjuvants, Anesthesia Phase 4,Phase 2
24 Analgesics Phase 4,Phase 3,Phase 2
25 Analgesics, Opioid Phase 4,Phase 2
26 Anesthetics Phase 4,Phase 3,Phase 2
27 Anesthetics, General Phase 4,Phase 2
28 Anesthetics, Intravenous Phase 4,Phase 2
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
30 Narcotics Phase 4,Phase 2
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
32 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1
33 Anti-Infective Agents Phase 4,Phase 3,Phase 1
34 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
37 Antirheumatic Agents Phase 4,Phase 3,Phase 2
38 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
39 Fibrinolytic Agents Phase 4,Phase 3
40 Antibiotics, Antitubercular Phase 4,Phase 1
41 Antitubercular Agents Phase 4,Phase 1
42 penicillins Phase 4,Phase 3
43 Adrenergic Agents Phase 4
44 Adrenergic Agonists Phase 4
45 Adrenergic alpha-2 Receptor Agonists Phase 4
46 Adrenergic alpha-Agonists Phase 4
47 BB 1101 Phase 4,Phase 2
48 Dexamethasone acetate Phase 4,Phase 2 1177-87-3
49 Hypnotics and Sedatives Phase 4,Phase 2
50 Neurotransmitter Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 78)

id Name Status NCT ID Phase Drugs
1 Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy Unknown status NCT00466544 Phase 4
2 Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
3 Multicenter, Open, Randomized Comparative Trial To Compare The Efficacy Of Azithromycin Versus Amoxicillin In Children With Strep Throat Completed NCT00643539 Phase 4 Zithromax;Clamoxyl
4 Efficacy of Tinoridine in Treating Pain and Inflammation in Adults Completed NCT01224756 Phase 4 Tinoridine HCl;Placebo
5 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed NCT00654511 Phase 4 Fentanyl;Fentanyl;Dexmedetomidine;Dexmedetomidine
6 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Completed NCT01267136 Phase 4 Codeine with acetaminophen;Tramadol suspension
7 Acetaminophen's Efficacy For Post-operative Pain Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
8 Recurrent Throat Infections and Tonsillectomy Completed NCT00547391 Phase 4
9 EXPAREL® for Pain After Tonsillectomy Completed NCT02444533 Phase 4 Liposomal Bupivacaine
10 Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold Completed NCT01465009 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Paracetamol;Placebo
11 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
12 DIAMANTE - Diseases Infectious Analysis Microflora Antibiotic Effect Completed NCT00424905 Phase 4 Bacillus clausii
13 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies Completed NCT01363531 Phase 4
14 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis Recruiting NCT03134443 Phase 4 Andrographolide sulfonate;Andrographolide sulfonate simulation
15 Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci Recruiting NCT02712307 Phase 4 Phenoxymethylpenicillin
16 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine
17 Post-tonsillectomy Pain Control in Adults Not yet recruiting NCT02358850 Phase 4 Norco (Hydrocodone and Acetaminophen);Percocet (Oxycodone and Acetaminophen);Dilaudid (hydromorphone);Tylenol (Acetaminophen)
18 Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients Terminated NCT00799838 Phase 4 Ketoprofen;Placebo (for Ketoprofen);Amoxicillin
19 Post-operative Pain Control After Pediatric Adenotonsillectomy Terminated NCT02296840 Phase 4 Ibuprofen;Hydrocodone-Acetaminophen
20 Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children Completed NCT00393744 Phase 3 pristinamycin;amoxicillin
21 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
22 A Multicenter, Randomized, Double-Blind, Double-Dummy Study Of Azithromycin SR Versus Amoxicillin For The Treatment Of Strep Throat In Children Completed NCT00643149 Phase 3 amoxicillin;azithromycin SR
23 A Multicenter, Randomized, Double-Blind, Double-Dummy Comparative Trial of Azithromycin Sustained Release Versus 3-Day Azithromycin for the Treatment of Strep Throat in Adolescents and Adults Completed NCT00644293 Phase 3 azithromycin (Zithromax);placebo;azithromycin SR;placebo
24 APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat Completed NCT00095368 Phase 3 Amoxicillin Pulsatile Release Multiparticulate Tablet (drug)
25 APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat Completed NCT00242281 Phase 3 APC-111 MP Tablet, 775 mg
26 Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold Completed NCT01361399 Phase 3 Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain;Acetylsalicylic Acid (Aspirin, BAYE4465);Lidocain;Placebo
27 CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study Completed NCT01948856 Phase 3 J022X ST;Placebo
28 TELI TON - Telithromycin in Tonsillitis Terminated NCT00315042 Phase 3 Telithromycin (HMR3647);Penicillin
29 TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults Terminated NCT00315549 Phase 3 Telithromycin;Penicillin
30 Comparison of Floseal Hemostasis Tonsillectomy With Coblation Tonsillectomy and Cautery Hemostasis Tonsillectomy Withdrawn NCT00459927 Phase 2, Phase 3
31 Evaluation of Coblation Channeling in Treating Chronic Tonsillitis Unknown status NCT01193790 Phase 2
32 A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis Completed NCT01988558 Phase 1, Phase 2 DL - Lactic Acid
33 Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants Completed NCT00610519 Phase 1, Phase 2
34 Efficacy and Safety of Meloxicam vs. Naproxen Sodium in Patients With Acute Non Bacterial Pharyngitis or Pharyngo-tonsillitis Completed NCT02183038 Phase 2 Meloxicam low;Meloxicam high;Naproxen sodium;Meloxicam placebo low;Meloxicam placebo high;Naproxen sodium placebo
35 Celecoxib as a Post-tonsillectomy Pain Medication Completed NCT00583453 Phase 2 Celecoxib;Placebo
36 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed NCT01691690 Phase 2 Acetaminophen (paracetamol);Normal Saline Flush;Midazolam;Sevoflurane;Nitrous Oxide/Oxygen;Propofol;Morphine;Ondansetron;Dexamethasone
37 PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients Terminated NCT01919996 Phase 2 Azithromycin
38 Evaluate Effects of Multiple Doses of Rifampin and Clarithromycin on the Single Dose Pharmacokinetics of Deflazacort Completed NCT02286635 Phase 1 Deflazacort and rifampin;Deflazacort and Clarithromycin
39 Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis Unknown status NCT01657968
40 Tonsillectomy in Recurrent Tonsillitis Unknown status NCT00136877
41 Vitamin D Levels in Children Undergoing Adenotonsillectomies and Controls Unknown status NCT00829972
42 KITS Study -Ketorolac In Tonsillectomy Surgery: a Double Blinded, Randomized Clinical Trial Unknown status NCT01498796 Ketorolac;Normal Saline
43 Study of Efficacy and Adverse Effects: Vessel Sealing System Tonsillectomy Versus Cold Knife Tonsillectomy Unknown status NCT00636402
44 Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing Unknown status NCT01344746
45 Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep Apnea (OSA) in Children Unknown status NCT00694772
46 Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage Unknown status NCT01715610 Clavulin;Randomization to Placebo;Clindamycin
47 The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess Unknown status NCT01227200 dypiron, tramadol
48 HPV Prevalence in the Mouth and Oropharynx of the Tonsillectomy Population Completed NCT01330147
49 Investigation of Clinical Spectrum, Bacterial Pathogens and Immune Response in Acute Pharyngotonsillitis Completed NCT00926198
50 Airway Management in Children Undergoing Adenotonsillectomies Completed NCT00570414

Search NIH Clinical Center for Tonsillitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: tonsillitis

Genetic Tests for Tonsillitis

Anatomical Context for Tonsillitis

MalaCards organs/tissues related to Tonsillitis:

39
Tonsil, Lymph Node, Testes, B Cells, T Cells, Neutrophil, Bone

Publications for Tonsillitis

Articles related to Tonsillitis:

(show top 50) (show all 954)
id Title Authors Year
1
Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. ( 28318453 )
2017
2
A comparison of tonsillar surface swabbing, fine-needle aspiration core sampling, and dissected tonsillar core biopsy culture in children with recurrent tonsillitis. ( 28636739 )
2017
3
Papillary squamous cell carcinoma of the palatine tonsil: a rare cancer of the head and neck. ( 28530265 )
2017
4
A rare complication of tonsillitis: septic arthritis of the temporomandibular joint. ( 28461120 )
2017
5
Triple-modality treatment in patients with advanced stage tonsil cancer. ( 28440876 )
2017
6
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
7
The carriage of interleukin-1B-31*C allele plus Staphylococcus aureus and Haemophilus influenzae increases the risk of recurrent tonsillitis in a Mexican population. ( 28542534 )
2017
8
The effect of tonsillotomy on chronic recurrent tonsillitis in children. ( 28471689 )
2017
9
A Retrospective Cohort Study of Glossopharyngeal Nerve Taste in Children with Recurrent Acute Tonsillitis. ( 28045639 )
2017
10
Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease: A Case Study Compared with Tonsillitis. ( 28467980 )
2017
11
Is tonsillectomy recommended in adults with recurrent tonsillitis? ( 28408369 )
2017
12
Hepatoid adenocarcinoma of the lung metastasizing to the tonsil. ( 28529745 )
2017
13
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study. ( 28854890 )
2017
14
Multimodality Treatment of Early-Stage Tonsil Cancer. ( 28669307 )
2017
15
Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial. ( 28779928 )
2017
16
Immune thrombocytopenia of childhood responsive to tonsillectomy in the setting of chronic tonsillitis: A case report and literature review. ( 28648251 )
2017
17
Vibrio vulnificus tonsillitis after swimming in the Gulf of Mexico. ( 28659373 )
2017
18
A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report. ( 28189144 )
2017
19
Follicular dendritic cell sarcoma of the head and neck. Literature review and report of the tonsil occurrence in a Ugandan patient. ( 28748971 )
2017
20
Primary mucosal melanoma of the palatine tonsil: Report of a case and review of the literature. ( 28449824 )
2017
21
Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis. ( 28952295 )
2017
22
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
23
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. ( 28877231 )
2017
24
The effect of tonsillectomy on the morbidity from recurrent tonsillitis. ( 28199053 )
2017
25
Staphylococcus aureus isolated from tonsillectomized adult patients with recurrent tonsillitis. ( 27862322 )
2017
26
Management of recurrent tonsillitis in children. ( 28385329 )
2017
27
Treatment Challenges of Group A Beta-hemolytic Streptococcal Pharyngo-Tonsillitis. ( 28680500 )
2017
28
Hyperplasia and the degree and activity of inflammation in chronic recurrent tonsillitis: a histopathological study. ( 28439693 )
2017
29
Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With CRTC1-MAML2 Fusion Transcript: Report of a Rare Case in a 17-Year-Old Boy and a Review of the Literature. ( 28637362 )
2017
30
Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study. ( 28891195 )
2017
31
The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children. ( 28380174 )
2017
32
The Impact of Tobacco Smoking Upon Chronic/Recurrent Tonsillitis and Post Tonsillectomy Bleeding. ( 28382125 )
2017
33
Previous tonsillectomy modifies odds of tonsil and base of tongue cancer. ( 26977858 )
2016
34
Evaluation of iron and zinc levels in recurrent tonsillitis and tonsillar hypertrophy. ( 26954864 )
2016
35
USE OF NEUTROPHILS TO LYMPHOCYTES RATIO AS AN INFLAMMATION MARKER IN PATIENTS WITH CHRONIC TONSILLITIS. ( 27845289 )
2016
36
Herpes simplex induced necrotizing tonsillitis in an immunocompromised patient with ulcerative colitis. ( 26881193 )
2016
37
Fulminant hepatic and multiple organ failure following acute viral tonsillitis: a case report. ( 26785992 )
2016
38
Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. ( 26539799 )
2016
39
Clinical practice guideline: tonsillitis II. Surgical management. ( 26882912 )
2016
40
Peritonsillar Abscess: Complication of Acute Tonsillitis or Weber's Glands Infection? ( 27026737 )
2016
41
Does the weekend effect influence the length of stay in patients admitted with tonsillitis, quinsy and epistaxis? A review of 363 emergency admissions over a 12-month period. ( 27273256 )
2016
42
Antibacterial resistance in Streptococcus pyogenes (GAS) from healthy carriers and tonsillitis patients and association with antibacterial sale in the Faroe Islands. ( 26833774 )
2016
43
Prevalence of Fusobacterium necrophorum in tonsils from patients with chronic tonsillitis. ( 27659315 )
2016
44
Asymptomatic Group A Streptococcus carriage in children with recurrent tonsillitis and tonsillar hypertrophy. ( 27260580 )
2016
45
Immune Defense in Upper Airways: A Single-Cell Study of Pathogen-Specific Plasmablasts and Their Migratory Potentials in Acute Sinusitis and Tonsillitis. ( 27128095 )
2016
46
Reduced germinal center follicular helper T cells but normal follicular regulatory T cells in the tonsils of a patient with a mutation in the PI3KR1 gene. ( 26827886 )
2016
47
RGB Measurements From Endoscopic Photography as a New and Objective Diagnostic Method for Chronic Tonsillitis. ( 26895768 )
2016
48
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. ( 26755048 )
2016
49
Effect of administration of Streptococcus salivarius K12 on the occurrence of streptococcal pharyngo-tonsillitis, scarlet fever and acute otitis media in 3 years old children. ( 27874935 )
2016
50
FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but notA -4 A>G andA -602A G>A. ( 27368434 )
2016

Variations for Tonsillitis

Expression for Tonsillitis

Search GEO for disease gene expression data for Tonsillitis.

Pathways for Tonsillitis

Pathways related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CD79A CXCL8 DEFB1 IFNG IL1A IL1B
2
Show member pathways
13.72 CXCL8 IFNG IL1A IL1B IL2 IL4
3
Show member pathways
13.61 CXCL8 IFNG IL1A IL1B IL2 IL4
4
Show member pathways
13.48 CXCL8 IL1A IL1B IL2 IL4 IL6
5
Show member pathways
13.46 CXCL8 IFNG IL1A IL1B IL2 IL4
6
Show member pathways
13.38 CXCL8 IL1A IL1B IL2 IL4 IL6
7
Show member pathways
13.31 CD79A IFNG IL1A IL1B IL2 IL4
8
Show member pathways
13.09 CXCL8 IL1A IL1B IL6 TLR10 TLR9
9
Show member pathways
13.01 CXCL8 IFNG IL1B IL2 IL6 TLR9
10
Show member pathways
12.87 CXCL8 IFNG IL1A IL1B IL2 IL4
11
Show member pathways
12.84 IL2 IL4 IL6 LTA TNF
12
Show member pathways
12.8 IL1A IL1B IL2 IL6 LTA TLR10
13
Show member pathways
12.79 CXCL8 IFNG IL1B IL6 TNF
14
Show member pathways
12.76 CXCL8 IFNG IL1A IL1B IL2 IL4
15
Show member pathways
12.74 IFNG IL1A IL1B LTA TNF
16
Show member pathways
12.73 IL1A IL1B LTA TLR10 TLR9 TNF
17
Show member pathways
12.72 IFNG IL1A IL1B IL2 IL4 IL6
18
Show member pathways
12.7 CD79A IFNG IL2 IL4 TNF
19
Show member pathways
12.67 IFNG IL1B IL2 IL6 TNF
20 12.65 CD79A IFNG IL1B IL2 IL4 TLR9
21
Show member pathways
12.56 IFNG IL1A IL1B IL2 IL4 IL6
22
Show member pathways
12.54 IFNG IL2 IL4 TNF
23
Show member pathways
12.48 CXCL8 IFNG IL1B IL4 IL6 TNF
24 12.47 IL2 IL6 LTA TNF
25
Show member pathways
12.4 CXCL8 IFNG IL1A IL1B IL6 TNF
26
Show member pathways
12.39 IFNG IL1A IL1B IL4 TNF
27 12.37 IFNG IL1A IL1B IL6 TLR9 TNF
28 12.32 IFNG IL6 TLR10 TLR9 TNF
29 12.32 CXCL8 IL1A IL1B IL6 TNF
30
Show member pathways
12.29 IFNG IL2 IL4 IL6
31
Show member pathways
12.26 CXCL8 IFNG IL1B IL4 IL6 TLR9
32
Show member pathways
12.19 IL1A IL1B IL2 TLR10 TLR9
33 12.18 IFNG IL1A IL1B TNF
34 12.14 IFNG IL1A IL1B TNF
35 12.14 CD79A IFNG IL2 IL4 IL6 TNF
36 12.12 CXCL8 IL1A IL1B IL4 IL6 TNF
37 12.11 CXCL8 IFNG IL1A IL1B IL6
38
Show member pathways
12.08 IFNG IL1B IL2 IL4
39 12.08 CXCL8 IL1A IL1B IL6 TNF
40 12.06 IL1B IL6 LTA TNF
41 12.06 IL1A IL1B IL4 IL6 TNF
42 12.06 CXCL8 IFNG IL1B IL6 TNF
43
Show member pathways
12.04 IFNG IL1B IL4 IL6 TLR10 TLR9
44 12 CXCL8 IL1B LTA TNF
45 11.99 CXCL8 IFNG IL1A IL1B IL6
46 11.97 CXCL8 IFNG IL2 IL4 IL6
47 11.97 CXCL8 IFNG IL1A IL1B IL6 TNF
48 11.94 CXCL8 IFNG IL1A IL1B IL2 IL4
49
Show member pathways
11.93 CXCL8 IFNG IL2 IL4 TNF
50 11.93 CXCL8 IL1A IL1B IL6 TNF

GO Terms for Tonsillitis

Cellular components related to Tonsillitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CXCL8 DEFB1 IFNG IL1A IL1B IL2
2 external side of plasma membrane GO:0009897 9.55 CD79A IFNG IL4 IL6 TNF
3 extracellular space GO:0005615 9.4 CXCL8 DEFB1 IFNG IL1A IL1B IL2

Biological processes related to Tonsillitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 DEFB1 IFNG TLR9 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 IL1B IL6 TLR9 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.93 CXCL8 IFNG IL6 TNF
4 positive regulation of angiogenesis GO:0045766 9.92 CXCL8 IL1A IL1B
5 response to ethanol GO:0045471 9.92 IL2 IL4 SOD1
6 activation of MAPK activity GO:0000187 9.92 IL1B SOD1 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.91 IL1B IL4 IL6 TNF
8 inflammatory response GO:0006954 9.91 CXCL8 IL1A IL1B IL6 TLR10 TLR9
9 defense response to Gram-negative bacterium GO:0050829 9.89 DEFB1 IL6 TLR9
10 defense response to Gram-positive bacterium GO:0050830 9.89 DEFB1 IL6 LTA TNF
11 positive regulation of protein phosphorylation GO:0001934 9.89 IFNG IL1B IL2 IL4 TNF
12 positive regulation of JNK cascade GO:0046330 9.88 IL1B TLR9 TNF
13 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
14 neutrophil chemotaxis GO:0030593 9.87 CXCL8 IFNG IL1B
15 positive regulation of inflammatory response GO:0050729 9.87 IL2 TLR10 TLR9
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4 IL6
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.82 IL1A IL1B TNF
18 humoral immune response GO:0006959 9.81 IFNG IL6 LTA TNF
19 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR9 TNF
20 defense response to protozoan GO:0042832 9.77 IFNG IL4 IL6
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.76 IL1B TLR9 TNF
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IFNG IL1B IL6 TNF
23 embryonic digestive tract development GO:0048566 9.75 CXCL8 TNF
24 negative regulation of lipid catabolic process GO:0050995 9.75 IL1B TNF
25 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR9 TNF
26 response to copper ion GO:0046688 9.74 IL1A SOD1
27 acute inflammatory response GO:0002526 9.74 DEFB1 IL6
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
29 response to molecule of bacterial origin GO:0002237 9.74 CXCL8 TLR9
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG IL1B TNF
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 IL1B TNF
32 regulation of cytokine secretion GO:0050707 9.73 TLR10 TLR9
33 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.73 IL1A IL1B
34 positive regulation of immunoglobulin secretion GO:0051024 9.73 IL2 IL6
35 positive regulation of protein import into nucleus, translocation GO:0033160 9.73 IFNG IL6
36 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
37 negative regulation of growth of symbiont in host GO:0044130 9.73 IFNG LTA TNF
38 positive regulation of interferon-gamma production GO:0032729 9.73 IL1B IL2 LTA TNF
39 myeloid cell homeostasis GO:0002262 9.72 IL6 SOD1
40 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.72 IL1A IL1B
41 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
42 regulation of defense response to virus by host GO:0050691 9.71 IFNG IL1B
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 IFNG IL1B
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IFNG IL4
45 ectopic germ cell programmed cell death GO:0035234 9.71 IL1A IL1B
46 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.71 IL1A IL1B IL2 IL4
47 positive regulation of B cell activation GO:0050871 9.7 IL4 IL6
48 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
49 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.68 IL6 TNF
50 fever generation GO:0001660 9.68 IL1A IL1B

Molecular functions related to Tonsillitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IFNG IL1A IL1B IL2 IL4
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B TLR9

Sources for Tonsillitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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