MCID: TTH002
MIFTS: 54

Tooth Agenesis malady

Categories: Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Tooth Agenesis

About this section
Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 25GTR, 48Novoseek, 37MeSH, 28ICD10, 30ICD9CM, 66UMLS, 29ICD10 via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Tooth Agenesis:

Name: Tooth Agenesis 11 13
Selective Tooth Agenesis 11 52 25
Oligodontia 11 52 25
Hypodontia 11 25 48
 
Tooth Agenesis, Selective 48
Familial Tooth Agenesis 11
Anodontia 37

Characteristics:

Orphanet epidemiological data:

52
selective tooth agenesis:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:0050591
ICD1028 K00.0
ICD9CM30 520.0
MeSH37 D000848
Orphanet52 ORPHA99798
ICD10 via Orphanet29 K00.0

Summaries for Tooth Agenesis

About this section
Wikipedia:69 In dentistry, hypodontia is the condition at which the patient has missing teeth as a result of the... more...

MalaCards based summary: Tooth Agenesis, also known as selective tooth agenesis, is related to tooth agenesis, selective, 1, with or without orofacial cleft and tooth agenesis, selective, 4, and has symptoms including taurodontia, abnormality of dental enamel and delayed eruption of teeth. An important gene associated with Tooth Agenesis is PAX9 (Paired Box 9), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone and heart, and related mouse phenotypes are no phenotypic analysis and adipose tissue.

Disease Ontology:11 A tooth disease characterized by failure to develop on or more missing teeth.

Related Diseases for Tooth Agenesis

About this section

Diseases related to Tooth Agenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1tooth agenesis, selective, 1, with or without orofacial cleft12.2
2tooth agenesis, selective, 412.2
3tooth agenesis, selective, 312.2
4tooth agenesis, selective, x-linked 112.2
5dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis12.1
6tooth agenesis selective 712.1
7tooth agenesis, selective, 212.0
8tooth agenesis, selective, 512.0
9hypodontia, x-linked11.9
10microdontia hypodontia short stature11.9
11epidermolysis bullosa simplex with anodontia/hypodontia11.9
12leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis11.8
13congenital heart disease ptosis hypodontia craniostosis11.8
14hypodontia of incisors and premolars11.8
15ectodermal dysplasia 3, witkop type11.5
16oligodontia-colorectal cancer syndrome11.3
17dental anomalies and short stature11.1
18ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.8EDAR, EDARADD
19walker dyson syndrome10.8EDAR, EDARADD, WNT10A
20idh3b-related retinitis pigmentosa10.7EDAR, EDARADD
21pertussis10.7EDA, EDAR, EDARADD
22scleroperikeratitis10.7EDA, EDAR, EDARADD
23auriculocondylar syndrome 310.7BMP4, DSP, IRF6, MSX1
24dementia, familial british10.6EDA, EDAR, EDARADD, WNT10A
25neuroschistosomiasis10.6AXIN2, EDA, EDARADD, MSX1, PAX9
26ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive10.6EDAR, EDARADD
27emery-dreifuss muscular dystrophy, x-linked10.6EDA, EDAR, EDARADD
28myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency10.6BMP4, FGFR1, IRF6, MSX1, TGFA
29myocardium cancer10.5BMP4, FGFR1, IRF6, MSX1, TGFA
30thanatophoric dysplasia, type ii10.5FGF10, FGF3, FGFR1
31mature cataract10.5COL1A2, MMP20
32seckel syndrome10.5BMP4, IRF6, MSX1
33ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.5EDA, EDAR, EDARADD, MSX1, PAX9, WNT10A
34ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.5EDAR, EDARADD
35fallopian tube disease10.3IRF6, WNT10A
36cleft lip10.1
37down syndrome10.1
38ectodermal dysplasia10.0
39orofacial cleft10.0
40ectodermal dysplasia, ectrodactyly, and macular dystrophy9.9
41colorectal cancer9.9
42taurodontism9.9
43velocardiofacial syndrome9.8
44myelomeningocele9.8
45heart disease9.8
46osteogenesis imperfecta9.8
47anodontia9.8
48hypothyroidism9.8
49congenital heart disease9.8
50ovarian cancer9.8

Graphical network of the top 20 diseases related to Tooth Agenesis:



Diseases related to tooth agenesis

Symptoms for Tooth Agenesis

About this section

Symptoms:

 52
  • abnormality of the face
  • hypoplasia of the maxilla
  • micrognathia
  • oligodontia
  • microdontia
  • abnormality of dental morphology

HPO human phenotypes related to Tooth Agenesis:

(show all 7)
id Description Frequency HPO Source Accession
1 taurodontia hallmark (90%) HP:0000679
2 abnormality of dental enamel hallmark (90%) HP:0000682
3 delayed eruption of teeth hallmark (90%) HP:0000684
4 dental malocclusion hallmark (90%) HP:0000689
5 reduced number of teeth hallmark (90%) HP:0009804
6 micrognathia hallmark (90%) HP:0000347
7 microdontia hallmark (90%) HP:0000691

Drugs & Therapeutics for Tooth Agenesis

About this section

Drugs for Tooth Agenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronPhase 310807439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
DeferasiroxPhase 387201530-41-85493381
Synonyms:
Deferasiroxum
Deferasiroxum [inn-latin]
 
Exjade
ICL 670
ICL 670a
deferasirox

Interventional clinical trials:

idNameStatusNCT IDPhase
1Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadCompletedNCT00235391Phase 3
2Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue GrowthCompletedNCT02740907
3Linkage and Identification of (a) Candidate Gene(s) for Tooth DisordersRecruitingNCT00026026
4Hypodontia and Ovarian CancerRecruitingNCT01470235
5Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168
6Clinical and Genetic Studies on HoloprosencephalyRecruitingNCT00088426
7Study of Selected X-Linked Disorders: Aicardi SyndromeRecruitingNCT00697411
8Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral TinnitusRecruitingNCT02630589

Search NIH Clinical Center for Tooth Agenesis


Cochrane evidence based reviews: anodontia

Genetic Tests for Tooth Agenesis

About this section

Genetic tests related to Tooth Agenesis:

id Genetic test Affiliating Genes
1 Hypodontia25
2 Selective Tooth Agenesis25
3 Oligodontia25

Anatomical Context for Tooth Agenesis

About this section

MalaCards organs/tissues related to Tooth Agenesis:

34
Bone, Heart

Animal Models for Tooth Agenesis or affiliated genes

About this section

MGI Mouse Phenotypes related to Tooth Agenesis:

39 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.1AXIN2, BMP4, FGF3, FGFR1, LRP6, MSX1
2MP:000537510.1COL1A2, EDAR, FGF10, LRP6, TGFA, WNT10A
3MP:000537710.0BMP4, EDARADD, FGF10, FGF3, FGFR1, IRF6
4MP:00053699.9BMP4, COL1A2, DSP, FGF10, FGFR1, MSX1
5MP:00028739.8AXIN2, BMP4, COL1A2, FGF10, FGF3, FGFR1
6MP:00053809.8AXIN2, BMP4, DSP, FGF10, FGF3, FGFR1
7MP:00053799.8AXIN2, BMP4, EDAR, EDARADD, FGF10, FGFR1
8MP:00053899.8AXIN2, BMP4, CHDH, EDARADD, FGF10, FGF3
9MP:00053819.7BMP4, DSP, EDAR, FGF10, FGFR1, IRF6
10MP:00053919.7AXIN2, BMP4, EDAR, EDARADD, FGF10, FGFR1
11MP:00053849.7AXIN2, BMP4, CHDH, COL1A2, DSP, EDAR
12MP:00107719.6BMP4, COL1A2, DSP, EDAR, EDARADD, FGF10
13MP:00053829.5AXIN2, BMP4, DSP, EDAR, EDARADD, FGF10
14MP:00053909.3AXIN2, BMP4, COL1A2, FGF10, FGF3, FGFR1
15MP:00053719.3AXIN2, BMP4, COL1A2, EDAR, EDARADD, FGF10
16MP:00107689.3AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD
17MP:00053788.9AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD

Publications for Tooth Agenesis

About this section

Articles related to Tooth Agenesis:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. (27090353)
2016
2
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. (26759063)
2016
3
Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis. (27311636)
2016
4
Prevalence of Tooth Agenesis in Adolescent Chinese Populations with or without Orthodontics. (25815384)
2015
5
Retrospective Study of Association between Displacement of Maxillary Canine and Tooth Agenesis. (26551375)
2015
6
WNT10A variants are associated with non-syndromic tooth agenesis in the general population. (24043634)
2014
7
Colorectal cancer and self-reported tooth agenesis. (24607150)
2014
8
The impact of tooth agenesis on oral health-related quality of life in children. (23794692)
2013
9
rs929387 of GLI3 is involved in tooth agenesis in Chinese Han population. (24278334)
2013
10
Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees. (23598609)
2013
11
PAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control study. (24160254)
2013
12
Complex analysis of multiple single nucleotide polymorphisms as putative risk factors of tooth agenesis in the Hungarian population. (23964635)
2013
13
Genetics of tooth agenesis: how to move the field forward. (23857660)
2013
14
A comparison of skeletal maturation in patients with tooth agenesis and unaffected controls assessed by the cervical vertebral maturation (CVM) index. (24297960)
2013
15
Novel missense mutation in PAX9 gene associated with familial tooth agenesis. (22747565)
2013
16
Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. (24312213)
2013
17
A 3-year prospective study of implant-supported, single-tooth restorations of all-ceramic and metal-ceramic materials in patients with tooth agenesis. (22708959)
2013
18
Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients. (23718693)
2013
19
Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review. (23235129)
2012
20
TGFB3 and BMP4 polymorphism are associated with isolated tooth agenesis. (22191848)
2012
21
Novel PAX9 and COL1A2 missense mutations causing tooth agenesis and OI/DGI without skeletal abnormalities. (23227268)
2012
22
Tooth agenesis: newer concept. (22900446)
2011
23
MMP1 and MMP20 contribute to tooth agenesis in humans. (21144496)
2011
24
Tooth agenesis. (22679169)
2011
25
Prevalence and patterns of permanent tooth agenesis in Down syndrome and their association with craniofacial morphology. (21208078)
2011
26
Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis. (19623212)
2010
27
Frequency and characteristics of tooth agenesis among an orthodontic patient population. (20383097)
2010
28
Correlation between the phenotype and genotype of tooth agenesis patients by tooth agenesis code]. (20602873)
2010
29
Tooth agenesis patterns in bilateral cleft lip/palate (BCLP) indicate possible common genetic pathways. (21093815)
2010
30
Functional aspects of treatment with implant-supported single crowns: a quality control study in subjects with tooth agenesis. (19845708)
2010
31
Tooth agenesis patterns in bilateral cleft lip and palate. (20156264)
2010
32
Dental implants in patients with ectodermal dysplasia and tooth agenesis: a critical review of the literature. (19548409)
2009
33
Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis. (18657636)
2008
34
Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population. (18452891)
2008
35
Investigating the etiology of multiple tooth agenesis in three sisters with severe oligodontia. (18199077)
2008
36
Can persistence of primary molars be predicted in subjects with multiple tooth agenesis? (18540013)
2008
37
Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjects. (18384350)
2008
38
Research advances in tooth agenesis]. (17304318)
2007
39
The role of MSX1 in tooth agenesis in Iranians. (17559452)
2007
40
Molecular characterization of a novel PAX9 missense mutation causing posterior tooth agenesis. (16479262)
2006
41
MSX1 and orofacial clefting with and without tooth agenesis. (16723652)
2006
42
Maxillary canine anomalies and tooth agenesis. (16093260)
2005
43
Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis. (12598542)
2003
44
Molecular basis of non-syndromic tooth agenesis: mutations of MSX1 and PAX9 reflect their role in patterning human dentition. (12974677)
2003
45
Is tooth agenesis related to brainstem anomalies in myelomeningocele patients with Chiari II malformations? (12512882)
2002
46
MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. (10742093)
2000
47
Haploinsufficiency of MSX1: a mechanism for selective tooth agenesis. (9742121)
1998
48
Can the location of tooth agenesis and the location of initial bone loss seen in juvenile periodontitis be explained by neural developmental fields in the jaws? (9083580)
1997
49
Site-specificity of tooth agenesis in subjects with maxillary canine malpositions. (8974184)
1996
50
Prevalence of tooth agenesis and peg-shaped maxillary lateral incisor associated with palatally displaced canine (PDC) anomaly. (8876497)
1996

Variations for Tooth Agenesis

About this section

Expression for genes affiliated with Tooth Agenesis

About this section
Search GEO for disease gene expression data for Tooth Agenesis.

Pathways for genes affiliated with Tooth Agenesis

About this section

Pathways related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
110.1BMP4, FGF10, FGFR1
210.1BMP4, FGF10, WNT10B
310.0AXIN2, BMP4, FGFR1, MSX1
4
Show member pathways
10.0AXIN2, LRP6, WNT10A, WNT10B
5
Show member pathways
10.0AXIN2, LRP6, WNT10A, WNT10B
610.0AXIN2, LRP6, WNT10A, WNT10B
7
Show member pathways
10.0AXIN2, BMP4, WNT10A, WNT10B
810.0AXIN2, BMP4, WNT10A, WNT10B
910.0BMP4, FGF10, FGFR1, TGFA
109.9AXIN2, BMP4, LRP6, MSX1, PAX9
11
Show member pathways
9.9AXIN2, FGFR1, LRP6, WNT10A, WNT10B
129.9AXIN2, BMP4, FGFR1, WNT10A, WNT10B
139.9BMP4, FGF10, FGF3, IRF6, MSX1
149.5AXIN2, BMP4, FGF10, FGF3, FGFR1, TGFA

GO Terms for genes affiliated with Tooth Agenesis

About this section

Cellular components related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:000557810.2BMP4, MMP20, WNT10A, WNT10B
2extracellular spaceGO:00056159.6BMP4, COL1A2, FGF10, MMP20, TGFA, WNT10A
3extracellular regionGO:00055768.9BMP4, COL1A2, EDA, FGF10, FGF3, FGFR1

Biological processes related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1regulation of odontogenesisGO:004248111.0MSX1, PAX9
2middle ear morphogenesisGO:004247411.0FGFR1, MSX1
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:006066511.0FGF10, FGFR1
4salivary gland cavitationGO:006066211.0EDA, EDAR
5neural crest cell differentiationGO:001403311.0LRP6, WNT10A
6epithelial to mesenchymal transition involved in endocardial cushion formationGO:000319810.9BMP4, MSX1
7BMP signaling pathway involved in heart developmentGO:006131210.9BMP4, MSX1
8secondary heart field specificationGO:000313910.9AXIN2, BMP4
9positive regulation of ossificationGO:004577810.9BMP4, WNT10B
10salivary gland morphogenesisGO:000743510.9FGF10, FGFR1
11epidermis morphogenesisGO:004873010.9FGF10, WNT10A
12bud elongation involved in lung branchingGO:006044910.9BMP4, FGF10
13keratinocyte proliferationGO:004361610.8FGF10, IRF6
14mesonephros developmentGO:000182310.8BMP4, FGF10
15cell fate commitmentGO:004516510.8BMP4, WNT10A, WNT10B
16branching involved in salivary gland morphogenesisGO:006044510.8FGF10, FGFR1
17phosphatidylinositol-3-phosphate biosynthetic processGO:003609210.8FGF10, FGF3, FGFR1
18organ inductionGO:000175910.7BMP4, FGF10, FGFR1
19Wnt signaling pathway involved in somitogenesisGO:009024410.7AXIN2, LRP6
20smooth muscle cell differentiationGO:005114510.7BMP4, FGF10
21phosphatidylinositol phosphorylationGO:004685410.7FGF10, FGF3, FGFR1
22regulation of phosphatidylinositol 3-kinase signalingGO:001406610.7FGF10, FGF3, FGFR1
23pituitary gland developmentGO:002198310.7BMP4, FGF10, MSX1
24phosphatidylinositol-mediated signalingGO:004801510.7FGF10, FGF3, FGFR1
25chondrocyte differentiationGO:000206210.6BMP4, FGFR1, WNT10B
26fibroblast growth factor receptor signaling pathwayGO:000854310.6FGF10, FGF3, FGFR1
27epithelial tube branching involved in lung morphogenesisGO:006044110.6BMP4, FGF10
28epidermis developmentGO:000854410.6DSP, EDAR, FGF10
29skin developmentGO:004358810.6DSP, EDA, IRF6, WNT10A
30face morphogenesisGO:006032510.5LRP6, MSX1, PAX9
31lung developmentGO:003032410.5BMP4, FGF10, FGFR1
32embryonic limb morphogenesisGO:003032610.5BMP4, FGFR1, MSX1
33angiogenesisGO:000152510.4BMP4, FGF10, FGFR1, TGFA
34regulation of odontogenesis of dentin-containing toothGO:004248710.4BMP4, WNT10A
35positive regulation of epithelial cell proliferationGO:005067910.4BMP4, FGF10, TGFA
36positive regulation of gene expressionGO:001062810.3BMP4, EDA, EDAR, WNT10A
37positive regulation of canonical Wnt signaling pathwayGO:009026310.2AXIN2, EDA, FGF10, LRP6, WNT10B
38odontogenesisGO:004247610.2AXIN2, BMP4, COL1A2, MSX1, PAX9, WNT10A
39cell differentiationGO:003015410.2EDA, EDAR, EDARADD, FGF10, FGF3
40odontogenesis of dentin-containing toothGO:004247510.1BMP4, EDA, EDAR, FGF10, LRP6, MSX1
41Wnt signaling pathwayGO:001605510.1AXIN2, LRP6, WNT10A, WNT10B
42negative regulation of cell proliferationGO:000828510.0AXIN2, BMP4, FGF10, IRF6, MSX1
43wound healingGO:004206010.0BMP4, DSP, FGF10, TGFA
44positive regulation of cell proliferationGO:00082849.6BMP4, FGF10, FGF3, FGFR1, TGFA, WNT10B
45positive regulation of transcription from RNA polymerase II promoterGO:00459449.5BMP4, FGF10, LRP6, MSX1, PAX9, WNT10B

Molecular functions related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:001630310.8FGF10, FGF3, FGFR1
2phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.8FGF10, FGF3, FGFR1
3frizzled bindingGO:000510910.8LRP6, WNT10A, WNT10B
4Ras guanyl-nucleotide exchange factor activityGO:000508810.6FGF10, FGF3, FGFR1
5growth factor activityGO:000808310.5BMP4, FGF10, FGF3, TGFA
6protein bindingGO:00055158.4AXIN2, BMP4, CHDH, COL1A2, DSP, EDA

Sources for Tooth Agenesis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet