MCID: TTH002
MIFTS: 54

Tooth Agenesis malady

Categories: Oral diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Tooth Agenesis

Aliases & Descriptions for Tooth Agenesis:

Name: Tooth Agenesis 12 14
Selective Tooth Agenesis 12 56 29
Oligodontia 12 56 29
Hypodontia 12 29 52
Tooth Agenesis, Selective 52
Familial Tooth Agenesis 12
Anodontia 42

Characteristics:

Orphanet epidemiological data:

56
oligodontia
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare odontological diseases


External Ids:

Disease Ontology 12 DOID:0050591
ICD10 33 K00.0
ICD9CM 35 520.0
MeSH 42 D000848
Orphanet 56 ORPHA99798
ICD10 via Orphanet 34 K00.0
UMLS 69 C0399352

Summaries for Tooth Agenesis

Disease Ontology : 12 A tooth disease characterized by failure to develop on or more missing teeth.

MalaCards based summary : Tooth Agenesis, also known as selective tooth agenesis, is related to tooth agenesis, selective, 1, with or without orofacial cleft and tooth agenesis, selective, 4, and has symptoms including micrognathia, microdontia and hypoplasia of the maxilla. An important gene associated with Tooth Agenesis is PAX9 (Paired Box 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Glioma. The drugs Deferasirox and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and growth/size/body region

Wikipedia : 71 In dentistry, hypodontia is the condition at which the patient has missing teeth as a result of the... more...

Related Diseases for Tooth Agenesis

Diseases related to Tooth Agenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 tooth agenesis, selective, 1, with or without orofacial cleft 12.3
2 tooth agenesis, selective, 4 12.2
3 tooth agenesis, selective, 3 12.2
4 tooth agenesis, selective, x-linked 1 12.2
5 tooth agenesis, selective, 7 12.2
6 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 12.2
7 tooth agenesis, selective, 8 12.2
8 leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 12.2
9 tooth agenesis, selective, 9 12.1
10 dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis 12.1
11 tooth agenesis, selective, 2 11.9
12 tooth agenesis, selective, 5 11.8
13 hypodontia, x-linked 11.8
14 microdontia hypodontia short stature 11.8
15 epidermolysis bullosa simplex with anodontia/hypodontia 11.8
16 congenital heart disease ptosis hypodontia craniostosis 11.7
17 leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis 11.7
18 hypodontia of incisors and premolars 11.7
19 oligodontia-colorectal cancer syndrome 11.4
20 dental anomalies and short stature 11.1
21 deafness, congenital, and onychodystrophy, autosomal dominant 10.8
22 ectodermal dysplasia, ectrodactyly, and macular dystrophy 10.8
23 prostate cancer 10.4 EDAR EDARADD
24 insr-related hyperinsulinism 10.4 EDAR EDARADD WNT10A
25 hypoplastic thumbs hydranencephaly 10.3 EDAR EDARADD WNT10A
26 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.3 EDAR EDARADD
27 neonatal respiratory failure 10.3 EDA EDAR EDARADD
28 lower lip fistula 10.3 IRF6 MSX1
29 t cell immunodeficiency primary 10.3 BMP4 FGFR1 TGFB3
30 dementia, familial british 10.3 EDA EDAR EDARADD WNT10A
31 beriberi 10.3 AXIN2 EDA EDARADD MSX1 PAX9
32 cleft palate with ankyloglossia 10.3 EDA EDARADD
33 end stage renal failure 10.3 EDA EDAR EDARADD
34 epidermolysis bullosa, lethal acantholytic 10.3 DSP TGFB3
35 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.3 EDAR EDARADD
36 nanophthalmos 3 10.3 EDA EDAR EDARADD MSX1 PAX9 WNT10A
37 familial abdominal aortic aneurysm 10.3 BMP4 FGFR1 IRF6 MSX1 TGFA
38 spondylocostal dysostosis 3 10.2 FGFR1 SUMO1 WNT10B
39 pallister-killian syndrome 10.2 DSP TGFB3
40 myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency 10.2 BMP4 FGFR1 IRF6 MSX1 TGFA TGFB3
41 hereditary lymphedema 10.2 BMP4 IRF6 MSX1 SUMO1 TGFB3
42 fibrous dysplasia 10.1 IRF6 MSX1 TGFB3
43 chronic ethmoiditis 10.1 BMP4 FGFR1 IRF6 MSX1 PAX9 SUMO1
44 cleft lip 10.0
45 orofacial cleft 10.0
46 down syndrome 10.0
47 ectodermal dysplasia 9.9
48 taurodontism 9.8
49 colorectal cancer 9.8
50 velocardiofacial syndrome 9.7

Graphical network of the top 20 diseases related to Tooth Agenesis:



Diseases related to Tooth Agenesis

Symptoms & Phenotypes for Tooth Agenesis

Human phenotypes related to Tooth Agenesis:

56 32 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 micrognathia 56 32 Very frequent (99-80%) HP:0000347
2 microdontia 56 32 Very frequent (99-80%) HP:0000691
3 hypoplasia of the maxilla 56 32 Very frequent (99-80%) HP:0000327
4 oligodontia 56 32 Very frequent (99-80%) HP:0000677
5 abnormality of the face 56 Very frequent (99-80%)
6 abnormality of dental morphology 56 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Tooth Agenesis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.86 WNT10B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.86 WNT10B AXIN2 LRP6
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.86 WNT10B LRP6
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-155 9.86 WNT10B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.86 WNT10B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.86 LRP6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.86 LRP6
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.86 WNT10B LRP6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.86 AXIN2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.86 WNT10B
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.86 WNT10B
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.86 AXIN2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 FGFR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 EDA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.78 IRF6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 IRF6
17 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.78 CHDH
18 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 FGFR1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 FGFR1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 TGFA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 FGFR1 IRF6 TGFA CHDH EDA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 IRF6
23 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.78 FGFR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.78 CHDH
25 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.78 TGFA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 EDA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 FGFR1 IRF6
28 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.78 CHDH
29 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.78 FGFR1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 FGFR1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IRF6
32 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 FGFR1 EDA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.78 EDA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 FGFR1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 TGFA

MGI Mouse Phenotypes related to Tooth Agenesis:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.42 MMP20 MSX1 PAX9 SUMO1 TGFA TGFB3
2 craniofacial MP:0005382 10.41 MMP20 MSX1 PAX9 SUMO1 TGFA TGFB3
3 cellular MP:0005384 10.29 COL1A2 DSP EDAR FGFR1 IRF6 LRP6
4 digestive/alimentary MP:0005381 10.26 SUMO1 TGFA TGFB3 BMP4 DSP EDAR
5 mortality/aging MP:0010768 10.25 FGF3 FGFR1 IRF6 LRP6 MSX1 PAX9
6 cardiovascular system MP:0005385 10.21 AXIN2 BMP4 COL1A2 DSP EDAR FGFR1
7 embryo MP:0005380 10.21 LRP6 MSX1 PAX9 TGFB3 AXIN2 BMP4
8 limbs/digits/tail MP:0005371 10.21 AXIN2 BMP4 COL1A2 EDAR EDARADD FGF3
9 integument MP:0010771 10.2 BMP4 COL1A2 DSP EDAR EDARADD FGFR1
10 hearing/vestibular/ear MP:0005377 10.08 BMP4 EDARADD FGF3 FGFR1 IRF6 LRP6
11 muscle MP:0005369 9.97 BMP4 COL1A2 DSP FGFR1 MSX1 PAX9
12 normal MP:0002873 9.91 AXIN2 BMP4 COL1A2 FGF3 FGFR1 LRP6
13 no phenotypic analysis MP:0003012 9.87 AXIN2 BMP4 FGF3 FGFR1 LRP6 MSX1
14 reproductive system MP:0005389 9.85 AXIN2 BMP4 CHDH EDAR EDARADD FGF3
15 skeleton MP:0005390 9.77 WNT10A AXIN2 BMP4 COL1A2 EDARADD FGF3
16 vision/eye MP:0005391 9.28 AXIN2 BMP4 EDAR EDARADD FGFR1 LRP6

Drugs & Therapeutics for Tooth Agenesis

Drugs for Tooth Agenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Deferasirox Approved, Investigational Phase 3 201530-41-8 5493381
2
Iron Approved Phase 3 7439-89-6 23925
3 Chelating Agents Phase 3
4 Iron Chelating Agents Phase 3
5 Micronutrients Phase 3
6 Trace Elements Phase 3
7 Orange Nutraceutical Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload Completed NCT00235391 Phase 3
2 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
3 Hypodontia and Ovarian Cancer Unknown status NCT01470235
4 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
5 Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus Recruiting NCT02630589
6 Study of Selected X-Linked Disorders: Aicardi Syndrome Recruiting NCT00697411
7 Clinical and Genetic Studies on Holoprosencephaly Recruiting NCT00088426
8 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Tooth Agenesis

Cochrane evidence based reviews: anodontia

Genetic Tests for Tooth Agenesis

Genetic tests related to Tooth Agenesis:

id Genetic test Affiliating Genes
1 Hypodontia 29
2 Selective Tooth Agenesis 29
3 Oligodontia 29

Anatomical Context for Tooth Agenesis

MalaCards organs/tissues related to Tooth Agenesis:

39
Bone, Heart

Publications for Tooth Agenesis

Articles related to Tooth Agenesis:

(show top 50) (show all 147)
id Title Authors Year
1
Dental anomaly patterns associated with tooth agenesis. ( 28121195 )
2017
2
Nonsyndromic oligodontia : Does the Tooth Agenesis Code (TAC) enable prediction of the causative mutation? ( 28204848 )
2017
3
Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population. ( 28288390 )
2017
4
Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing. ( 28265457 )
2017
5
Prevalence of delayed tooth development and its relation to tooth agenesis in Korean children. ( 27810381 )
2017
6
PAX9 gene mutations and tooth agenesis: A review. ( 28155232 )
2017
7
Tooth agenesis and orofacial clefting: genetic brothers in arms? ( 27699475 )
2016
8
Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. ( 27365112 )
2016
9
Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis. ( 27665865 )
2016
10
Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis. ( 27311636 )
2016
11
A novel heterozygous mutation in desmoplakin gene in a Lebanese patient with Carvajal syndrome and tooth agenesis. ( 26833927 )
2016
12
Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. ( 27090353 )
2016
13
Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis. ( 27895972 )
2016
14
Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. ( 27464525 )
2016
15
Tooth agenesis in osteogenesis imperfecta related to mutations in the collagen type I genes. ( 27510842 )
2016
16
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
17
Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. ( 27144394 )
2016
18
Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns. ( 27933446 )
2016
19
Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis. ( 26963285 )
2016
20
Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis. ( 27362534 )
2016
21
Clinical and Radiographic Evaluation of a Small-Diameter Dental Implant Used for the Restoration of Patients with Permanent Tooth Agenesis (Hypodontia) in the Maxillary Lateral Incisor and Mandibular Incisor Regions: A 36-Month Follow-Up. ( 26929953 )
2016
22
Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: a case-control study. ( 26166641 )
2015
23
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population. ( 26707046 )
2015
24
An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. ( 26030286 )
2015
25
Permanent Tooth Agenesis and Maxillary Hypoplasia in Patients with Unilateral Cleft Lip and Palate. ( 26505722 )
2015
26
Prevalence of Tooth Agenesis in Adolescent Chinese Populations with or without Orthodontics. ( 25815384 )
2015
27
Prevalence and distribution of dental anomalies: A comparison between maxillary and mandibular tooth agenesis. ( 26522039 )
2015
28
Prevalence and patterns of tooth agenesis in Angle Class II Division 2 malocclusion in Japan. ( 26124035 )
2015
29
Retrospective Study of Association between Displacement of Maxillary Canine and Tooth Agenesis. ( 26551375 )
2015
30
Prevalence and patterns of permanent tooth agenesis in patients with nonsyndromic Pierre Robin sequence. ( 24703283 )
2014
31
WNT10A variants are associated with non-syndromic tooth agenesis in the general population. ( 24043634 )
2014
32
Whole genome sequencing reveals novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis. ( 25203534 )
2014
33
Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis. ( 24436340 )
2014
34
Mutations in the MSX1 gene in Turkish children with non-syndromic tooth agenesis and other dental anomalies. ( 25565750 )
2014
35
Colorectal cancer and self-reported tooth agenesis. ( 24607150 )
2014
36
Prevalence and patterns of tooth agenesis among Malay children. ( 24968691 )
2014
37
The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. ( 24700731 )
2014
38
Is there a link between ovarian cancer and tooth agenesis? ( 24631698 )
2014
39
Characterization of novel MSX1 mutations identified in Japanese patients with nonsyndromic tooth agenesis. ( 25101640 )
2014
40
A study of prevalence and distribution of tooth agenesis. ( 25713620 )
2014
41
Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population. ( 24737523 )
2014
42
Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study. ( 25041097 )
2014
43
Exclusion of pax9 and msx1 mutation in six families affected by tooth agenesis. A genetic study and literature review. ( 24316698 )
2013
44
Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations. ( 23991204 )
2013
45
Genetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population. ( 24351915 )
2013
46
Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees. ( 23598609 )
2013
47
Tooth agenesis association with self-reported family history of cancer. ( 23169889 )
2013
48
rs929387 of GLI3 is involved in tooth agenesis in Chinese Han population. ( 24278334 )
2013
49
Tooth agenesis patterns in unilateral cleft lip and palate in humans. ( 23295124 )
2013
50
Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. ( 24312213 )
2013

Variations for Tooth Agenesis

ClinVar genetic disease variations for Tooth Agenesis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 LRP6 NM_002336.2(LRP6): c.4593delC (p.Cys1532Alafs) deletion Pathogenic rs869320635 GRCh37 Chromosome 12, 12274309: 12274309
2 LRP6 NM_002336.2(LRP6): c.3398-2A> C single nucleotide variant Pathogenic rs869320636 GRCh37 Chromosome 12, 12291470: 12291470

Expression for Tooth Agenesis

Search GEO for disease gene expression data for Tooth Agenesis.

Pathways for Tooth Agenesis

Pathways related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 COL1A2 EDA EDAR EDARADD FGF3 FGFR1
2
Show member pathways
12.77 AXIN2 FGF3 FGFR1 LRP6 TGFA WNT10A
3
Show member pathways
12.37 AXIN2 BMP4 FGFR1 PAX9
4
Show member pathways
12.32 BMP4 TGFB3 WNT10A WNT10B
5
Show member pathways
12.3 AXIN2 FGFR1 LRP6 WNT10A WNT10B
6 12.27 MSX1 TGFB3 WNT10A WNT10B
7
Show member pathways
12.18 AXIN2 BMP4 WNT10A WNT10B
8
Show member pathways
12.03 AXIN2 LRP6 WNT10A WNT10B
9 11.94 AXIN2 LRP6 TGFB3 WNT10A WNT10B
10 11.88 BMP4 FGF3 IRF6 MSX1
11 11.84 AXIN2 BMP4 TGFB3 WNT10A WNT10B
12 11.82 AXIN2 BMP4 FGF3 FGFR1 TGFA TGFB3
13 11.73 BMP4 TGFB3 WNT10B
14 11.71 AXIN2 BMP4 FGFR1 MSX1
15 11.7 AXIN2 BMP4 FGFR1 WNT10A WNT10B
16 11.69 AXIN2 BMP4 LRP6 MSX1 PAX9 TGFB3
17 11.66 FGFR1 TGFA TGFB3
18
Show member pathways
11.64 EDA EDAR EDARADD
19 10.41 IRF6 TGFB3

GO Terms for Tooth Agenesis

Cellular components related to Tooth Agenesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.36 BMP4 COL1A2 EDA FGF3 FGFR1 LRP6
2 proteinaceous extracellular matrix GO:0005578 9.35 BMP4 COL1A2 MMP20 WNT10A WNT10B

Biological processes related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 AXIN2 BMP4 IRF6 MSX1 TGFB3
2 Wnt signaling pathway GO:0016055 9.89 AXIN2 LRP6 WNT10A WNT10B
3 wound healing GO:0042060 9.81 DSP TGFA TGFB3
4 BMP signaling pathway GO:0030509 9.8 BMP4 MSX1 TGFB3
5 cell fate commitment GO:0045165 9.74 BMP4 WNT10A WNT10B
6 embryonic limb morphogenesis GO:0030326 9.73 BMP4 FGFR1 MSX1
7 positive regulation of canonical Wnt signaling pathway GO:0090263 9.71 AXIN2 EDA LRP6 WNT10B
8 multicellular organism development GO:0007275 9.7 AXIN2 BMP4 EDA EDAR EDARADD FGF3
9 positive regulation of cell division GO:0051781 9.69 FGF3 TGFA TGFB3
10 palate development GO:0060021 9.67 LRP6 MSX1 SUMO1 TGFB3
11 chondrocyte differentiation GO:0002062 9.65 BMP4 FGFR1 WNT10B
12 positive regulation of ossification GO:0045778 9.64 BMP4 WNT10B
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.63 BMP4 MSX1
14 skin development GO:0043588 9.62 DSP EDA IRF6 WNT10A
15 positive regulation of SMAD protein import into nucleus GO:0060391 9.61 BMP4 TGFB3
16 organ induction GO:0001759 9.61 BMP4 FGFR1
17 positive regulation of bone mineralization GO:0030501 9.61 BMP4 TGFB3 WNT10B
18 salivary gland morphogenesis GO:0007435 9.6 FGFR1 TGFB3
19 secondary heart field specification GO:0003139 9.58 AXIN2 BMP4
20 face morphogenesis GO:0060325 9.56 LRP6 MSX1 PAX9 TGFB3
21 BMP signaling pathway involved in heart development GO:0061312 9.55 BMP4 MSX1
22 odontogenesis of dentin-containing tooth GO:0042475 9.55 BMP4 EDA EDAR LRP6 MSX1
23 neural crest cell differentiation GO:0014033 9.54 LRP6 WNT10A
24 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.52 BMP4 WNT10A
25 salivary gland cavitation GO:0060662 9.49 EDA EDAR
26 regulation of odontogenesis GO:0042481 9.46 MSX1 PAX9
27 odontogenesis GO:0042476 9.17 AXIN2 BMP4 COL1A2 MSX1 PAX9 TGFB3
28 cell differentiation GO:0030154 10.11 BMP4 EDA EDAR EDARADD FGF3 IRF6
29 positive regulation of cell proliferation GO:0008284 10.02 BMP4 FGF3 FGFR1 TGFA WNT10B

Molecular functions related to Tooth Agenesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.43 COL1A2 DSP SUMO1
2 growth factor activity GO:0008083 9.26 BMP4 FGF3 TGFA TGFB3
3 frizzled binding GO:0005109 8.8 LRP6 WNT10A WNT10B
4 protein binding GO:0005515 10.09 AXIN2 BMP4 CHDH COL1A2 DSP EDA

Sources for Tooth Agenesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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