MCID: TTH002
MIFTS: 54

Tooth Agenesis malady

Categories: Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Tooth Agenesis

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Sources:
11Disease Ontology, 13DISEASES, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Tooth Agenesis:

Name: Tooth Agenesis 11 13
Selective Tooth Agenesis 11 54 27
Oligodontia 11 54 27
Hypodontia 11 27 50
 
Tooth Agenesis, Selective 50
Familial Tooth Agenesis 11
Anodontia 39

Characteristics:

Orphanet epidemiological data:

54
selective tooth agenesis:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:0050591
ICD1030 K00.0
ICD9CM32 520.0
MeSH39 D000848
Orphanet54 ORPHA99798
ICD10 via Orphanet31 K00.0

Summaries for Tooth Agenesis

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Wikipedia:71 In dentistry, hypodontia is the condition at which the patient has missing teeth as a result of the... more...

MalaCards based summary: Tooth Agenesis, also known as selective tooth agenesis, is related to tooth agenesis, selective, 1, with or without orofacial cleft and tooth agenesis, selective, 4, and has symptoms including Array, Array and Array. An important gene associated with Tooth Agenesis is PAX9 (Paired Box 9), and among its related pathways are Hypothetical Craniofacial Development Pathway and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. Affiliated tissues include bone and heart, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and Decreased shRNA abundance (Z-score < -2).

Disease Ontology:11 A tooth disease characterized by failure to develop on or more missing teeth.

Related Diseases for Tooth Agenesis

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Diseases related to Tooth Agenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1tooth agenesis, selective, 1, with or without orofacial cleft12.3
2tooth agenesis, selective, 412.2
3tooth agenesis, selective, 312.2
4tooth agenesis, selective, x-linked 112.2
5tooth agenesis, selective, 712.2
6leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism12.2
7tooth agenesis, selective, 812.2
8leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism12.2
9tooth agenesis, selective, 912.1
10dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis12.1
11tooth agenesis, selective, 211.9
12tooth agenesis, selective, 511.8
13hypodontia, x-linked11.8
14microdontia hypodontia short stature11.8
15epidermolysis bullosa simplex with anodontia/hypodontia11.8
16leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis11.7
17congenital heart disease ptosis hypodontia craniostosis11.7
18hypodontia of incisors and premolars11.7
19oligodontia-colorectal cancer syndrome11.4
20dental anomalies and short stature11.1
21ectodermal dysplasia, ectrodactyly, and macular dystrophy10.8
22deafness, congenital, and onychodystrophy, autosomal dominant10.8
23prostate cancer10.4EDAR, EDARADD
24insr-related hyperinsulinism10.4EDAR, EDARADD, WNT10A
25hypoplastic thumbs hydranencephaly10.3EDAR, EDARADD, WNT10A
26ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.3EDAR, EDARADD
27neonatal respiratory failure10.3EDA, EDAR, EDARADD
28lower lip fistula10.3IRF6, MSX1
29t cell immunodeficiency primary10.3BMP4, FGFR1, TGFB3
30dementia, familial british10.3EDA, EDAR, EDARADD, WNT10A
31beriberi10.3AXIN2, EDA, EDARADD, MSX1, PAX9
32cleft palate with ankyloglossia10.3EDA, EDARADD
33end stage renal failure10.3EDA, EDAR, EDARADD
34epidermolysis bullosa, lethal acantholytic10.3DSP, TGFB3
35ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.3EDAR, EDARADD
36nanophthalmos 310.3EDA, EDAR, EDARADD, MSX1, PAX9, WNT10A
37familial abdominal aortic aneurysm10.3BMP4, FGFR1, IRF6, MSX1, TGFA
38spondylocostal dysostosis 310.2FGFR1, SUMO1, WNT10B
39pallister-killian syndrome10.2DSP, TGFB3
40myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency10.2BMP4, FGFR1, IRF6, MSX1, TGFA, TGFB3
41hereditary lymphedema10.2BMP4, IRF6, MSX1, SUMO1, TGFB3
42fibrous dysplasia10.1IRF6, MSX1, TGFB3
43chronic ethmoiditis10.1BMP4, FGFR1, IRF6, MSX1, PAX9, SUMO1
44cleft lip10.0
45orofacial cleft10.0
46down syndrome10.0
47ectodermal dysplasia9.9
48colorectal cancer9.8
49taurodontism9.8
50velocardiofacial syndrome9.7

Graphical network of the top 20 diseases related to Tooth Agenesis:



Diseases related to tooth agenesis

Symptoms & Phenotypes for Tooth Agenesis

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Human phenotypes related to Tooth Agenesis:

 54 64 (show all 6)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the face54 Very frequent (99-80%)
2 hypoplasia of the maxilla64 54 Very frequent (99-80%) HP:0000327
3 micrognathia64 54 Very frequent (99-80%) HP:0000347
4 oligodontia64 54 Very frequent (99-80%) HP:0000677
5 microdontia64 54 Very frequent (99-80%) HP:0000691
6 abnormality of dental morphology54 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Tooth Agenesis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.9CHDH, EDA, FGFR1, IRF6, TGFA
2GR00366-A-849.9AXIN2, LRP6, WNT10B

MGI Mouse Phenotypes related to Tooth Agenesis according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.1BMP4, EDARADD, FGF3, FGFR1, IRF6, LRP6
2MP:000301210.0AXIN2, BMP4, FGF3, FGFR1, LRP6, MSX1
3MP:000539110.0AXIN2, BMP4, EDAR, EDARADD, FGFR1, LRP6
4MP:00053699.9BMP4, COL1A2, DSP, FGFR1, MSX1, PAX9
5MP:00053809.9AXIN2, BMP4, DSP, FGF3, FGFR1, IRF6
6MP:00053899.9AXIN2, BMP4, CHDH, EDAR, EDARADD, FGF3
7MP:00028739.8AXIN2, BMP4, COL1A2, FGF3, FGFR1, LRP6
8MP:00053859.8AXIN2, BMP4, COL1A2, DSP, EDAR, FGFR1
9MP:00053719.6AXIN2, BMP4, COL1A2, EDAR, EDARADD, FGF3
10MP:00053819.6BMP4, DSP, EDAR, FGFR1, IRF6, LRP6
11MP:00107719.6BMP4, COL1A2, DSP, EDAR, EDARADD, FGFR1
12MP:00053849.5AXIN2, BMP4, CHDH, COL1A2, DSP, EDAR
13MP:00053909.5AXIN2, BMP4, COL1A2, EDARADD, FGF3, FGFR1
14MP:00053829.5AXIN2, BMP4, DSP, EDAR, EDARADD, FGFR1
15MP:00107689.3AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD
16MP:00053788.9AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD

Drugs & Therapeutics for Tooth Agenesis

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Drugs for Tooth Agenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 311657439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
Deferasiroxapproved, investigationalPhase 389201530-41-85493381
Synonyms:
Deferasiroxum
Deferasiroxum [inn-latin]
 
Exjade
ICL 670
ICL 670a
deferasirox
3Trace ElementsPhase 36001
4MicronutrientsPhase 36001
5Iron Chelating AgentsPhase 3226
6Chelating AgentsPhase 31423
7OrangeNutraceuticalPhase 3265

Interventional clinical trials:

idNameStatusNCT IDPhase
1Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadCompletedNCT00235391Phase 3
2Linkage and Identification of (a) Candidate Gene(s) for Tooth DisordersUnknown statusNCT00026026
3Hypodontia and Ovarian CancerUnknown statusNCT01470235
4Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue GrowthCompletedNCT02740907
5Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral TinnitusRecruitingNCT02630589
6Study of Selected X-Linked Disorders: Aicardi SyndromeRecruitingNCT00697411
7Clinical and Genetic Studies on HoloprosencephalyRecruitingNCT00088426
8Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168

Search NIH Clinical Center for Tooth Agenesis


Cochrane evidence based reviews: anodontia

Genetic Tests for Tooth Agenesis

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Genetic tests related to Tooth Agenesis:

id Genetic test Affiliating Genes
1 Hypodontia27
2 Selective Tooth Agenesis27
3 Oligodontia27

Anatomical Context for Tooth Agenesis

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MalaCards organs/tissues related to Tooth Agenesis:

36
Bone, Heart

Publications for Tooth Agenesis

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Articles related to Tooth Agenesis:

(show top 50)    (show all 147)
idTitleAuthorsYear
1
Dental anomaly patterns associated with tooth agenesis. (28121195)
2017
2
Nonsyndromic oligodontia : Does the Tooth Agenesis Code (TAC) enable prediction of the causative mutation? (28204848)
2017
3
Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population. (28288390)
2017
4
Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing. (28265457)
2017
5
Prevalence of delayed tooth development and its relation to tooth agenesis in Korean children. (27810381)
2017
6
PAX9 gene mutations and tooth agenesis: A review. (28155232)
2017
7
Tooth agenesis and orofacial clefting: genetic brothers in arms? (27699475)
2016
8
Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. (27365112)
2016
9
Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis. (27665865)
2016
10
Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis. (27311636)
2016
11
A novel heterozygous mutation in desmoplakin gene in a Lebanese patient with Carvajal syndrome and tooth agenesis. (26833927)
2016
12
Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. (27090353)
2016
13
Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis. (27895972)
2016
14
Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. (27464525)
2016
15
Tooth agenesis in osteogenesis imperfecta related to mutations in the collagen type I genes. (27510842)
2016
16
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. (26759063)
2016
17
Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. (27144394)
2016
18
Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns. (27933446)
2016
19
Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis. (26963285)
2016
20
Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis. (27362534)
2016
21
Clinical and Radiographic Evaluation of a Small-Diameter Dental Implant Used for the Restoration of Patients with Permanent Tooth Agenesis (Hypodontia) in the Maxillary Lateral Incisor and Mandibular Incisor Regions: A 36-Month Follow-Up. (26929953)
2016
22
Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: a case-control study. (26166641)
2015
23
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population. (26707046)
2015
24
An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. (26030286)
2015
25
Permanent Tooth Agenesis and Maxillary Hypoplasia in Patients with Unilateral Cleft Lip and Palate. (26505722)
2015
26
Prevalence of Tooth Agenesis in Adolescent Chinese Populations with or without Orthodontics. (25815384)
2015
27
Prevalence and distribution of dental anomalies: A comparison between maxillary and mandibular tooth agenesis. (26522039)
2015
28
Prevalence and patterns of tooth agenesis in Angle Class II Division 2 malocclusion in Japan. (26124035)
2015
29
Retrospective Study of Association between Displacement of Maxillary Canine and Tooth Agenesis. (26551375)
2015
30
Prevalence and patterns of permanent tooth agenesis in patients with nonsyndromic Pierre Robin sequence. (24703283)
2014
31
WNT10A variants are associated with non-syndromic tooth agenesis in the general population. (24043634)
2014
32
Whole genome sequencing reveals novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis. (25203534)
2014
33
Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis. (24436340)
2014
34
Mutations in the MSX1 gene in Turkish children with non-syndromic tooth agenesis and other dental anomalies. (25565750)
2014
35
Colorectal cancer and self-reported tooth agenesis. (24607150)
2014
36
Prevalence and patterns of tooth agenesis among Malay children. (24968691)
2014
37
The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. (24700731)
2014
38
Is there a link between ovarian cancer and tooth agenesis? (24631698)
2014
39
Characterization of novel MSX1 mutations identified in Japanese patients with nonsyndromic tooth agenesis. (25101640)
2014
40
A study of prevalence and distribution of tooth agenesis. (25713620)
2014
41
Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population. (24737523)
2014
42
Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study. (25041097)
2014
43
Exclusion of pax9 and msx1 mutation in six families affected by tooth agenesis. A genetic study and literature review. (24316698)
2013
44
Candidate gene analysis of tooth agenesis identifies novel mutations in six genes and suggests significant role for WNT and EDA signaling and allele combinations. (23991204)
2013
45
Genetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population. (24351915)
2013
46
Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees. (23598609)
2013
47
Tooth agenesis association with self-reported family history of cancer. (23169889)
2013
48
rs929387 of GLI3 is involved in tooth agenesis in Chinese Han population. (24278334)
2013
49
Tooth agenesis patterns in unilateral cleft lip and palate in humans. (23295124)
2013
50
Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. (24312213)
2013

Variations for Tooth Agenesis

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Expression for genes affiliated with Tooth Agenesis

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Search GEO for disease gene expression data for Tooth Agenesis.

Pathways for genes affiliated with Tooth Agenesis

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Pathways related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
110.3IRF6, TGFB3
2
Show member pathways
10.2EDA, EDAR, EDARADD
3
Show member pathways
10.2FGFR1, TGFA, TGFB3
410.1BMP4, TGFB3, WNT10B
510.1MSX1, TGFB3, WNT10A, WNT10B
6
Show member pathways
10.1AXIN2, LRP6, WNT10A, WNT10B
7
Show member pathways
10.1AXIN2, BMP4, WNT10A, WNT10B
8
Show member pathways
10.1AXIN2, BMP4, FGFR1, PAX9
910.1AXIN2, BMP4, FGFR1, MSX1
10
Show member pathways
10.1BMP4, TGFB3, WNT10A, WNT10B
1110.1BMP4, FGF3, IRF6, MSX1
12
Show member pathways
10.0AXIN2, FGFR1, LRP6, WNT10A, WNT10B
1310.0AXIN2, LRP6, TGFB3, WNT10A, WNT10B
1410.0AXIN2, BMP4, FGFR1, WNT10A, WNT10B
1510.0AXIN2, BMP4, TGFB3, WNT10A, WNT10B
169.9AXIN2, BMP4, LRP6, MSX1, PAX9, TGFB3
17
Show member pathways
9.7AXIN2, FGF3, FGFR1, LRP6, TGFA, WNT10A
189.6AXIN2, BMP4, FGF3, FGFR1, TGFA, TGFB3
19
Show member pathways
9.6COL1A2, EDA, EDAR, EDARADD, FGF3, FGFR1

GO Terms for genes affiliated with Tooth Agenesis

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Cellular components related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.9BMP4, COL1A2, MMP20, WNT10A, WNT10B
2extracellular regionGO:00055769.9BMP4, COL1A2, EDA, FGF3, FGFR1, LRP6

Biological processes related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1BMP signaling pathway involved in heart developmentGO:006131211.1BMP4, MSX1
2epithelial to mesenchymal transition involved in endocardial cushion formationGO:000319811.0BMP4, MSX1
3neural crest cell differentiationGO:001403311.0LRP6, WNT10A
4organ inductionGO:000175911.0BMP4, FGFR1
5regulation of odontogenesisGO:004248110.9MSX1, PAX9
6BMP signaling pathwayGO:003050910.9BMP4, MSX1, TGFB3
7cell fate commitmentGO:004516510.9BMP4, WNT10A, WNT10B
8embryonic limb morphogenesisGO:003032610.9BMP4, FGFR1, MSX1
9chondrocyte differentiationGO:000206210.9BMP4, FGFR1, WNT10B
10salivary gland cavitationGO:006066210.9EDA, EDAR
11regulation of odontogenesis of dentin-containing toothGO:004248710.9BMP4, WNT10A
12positive regulation of ossificationGO:004577810.9BMP4, WNT10B
13secondary heart field specificationGO:000313910.9AXIN2, BMP4
14salivary gland morphogenesisGO:000743510.9FGFR1, TGFB3
15positive regulation of SMAD protein import into nucleusGO:006039110.9BMP4, TGFB3
16face morphogenesisGO:006032510.9LRP6, MSX1, PAX9, TGFB3
17positive regulation of bone mineralizationGO:003050110.8BMP4, TGFB3, WNT10B
18positive regulation of cell divisionGO:005178110.8FGF3, TGFA, TGFB3
19positive regulation of canonical Wnt signaling pathwayGO:009026310.8AXIN2, EDA, LRP6, WNT10B
20palate developmentGO:006002110.8LRP6, MSX1, SUMO1, TGFB3
21skin developmentGO:004358810.7DSP, EDA, IRF6, WNT10A
22negative regulation of cell proliferationGO:000828510.7AXIN2, BMP4, IRF6, MSX1, TGFB3
23odontogenesis of dentin-containing toothGO:004247510.7BMP4, EDA, EDAR, LRP6, MSX1
24Wnt signaling pathwayGO:001605510.6AXIN2, LRP6, WNT10A, WNT10B
25cell differentiationGO:003015410.6BMP4, EDA, EDAR, EDARADD, FGF3, IRF6
26positive regulation of cell proliferationGO:000828410.6BMP4, FGF3, FGFR1, TGFA, WNT10B
27odontogenesisGO:004247610.5AXIN2, BMP4, COL1A2, MSX1, PAX9, TGFB3
28wound healingGO:004206010.1DSP, TGFA, TGFB3
29multicellular organism developmentGO:000727510.1AXIN2, BMP4, EDA, EDAR, EDARADD, FGF3

Molecular functions related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:000510911.0LRP6, WNT10A, WNT10B
2growth factor activityGO:000808310.8BMP4, FGF3, TGFA, TGFB3
3protein binding, bridgingGO:003067410.1COL1A2, DSP, SUMO1
4protein bindingGO:00055159.1AXIN2, BMP4, CHDH, COL1A2, DSP, EDA

Sources for Tooth Agenesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet