MCID: TTH002
MIFTS: 55

Tooth Agenesis malady

Categories: Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Tooth Agenesis

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Sources:
11Disease Ontology, 13DISEASES, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Tooth Agenesis:

Name: Tooth Agenesis 11 13
Selective Tooth Agenesis 11 54 27
Oligodontia 11 54 27
Hypodontia 11 27 50
 
Tooth Agenesis, Selective 50
Familial Tooth Agenesis 11
Anodontia 39

Characteristics:

Orphanet epidemiological data:

54
selective tooth agenesis:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:0050591
ICD1030 K00.0
ICD9CM32 520.0
MeSH39 D000848
Orphanet54 ORPHA99798
ICD10 via Orphanet31 K00.0

Summaries for Tooth Agenesis

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Wikipedia:71 In dentistry, hypodontia is the condition at which the patient has missing teeth as a result of the... more...

MalaCards based summary: Tooth Agenesis, also known as selective tooth agenesis, is related to tooth agenesis, selective, 1, with or without orofacial cleft and tooth agenesis, selective, 4, and has symptoms including taurodontia, abnormality of dental enamel and delayed eruption of teeth. An important gene associated with Tooth Agenesis is PAX9 (Paired Box 9), and among its related pathways are Angiogenesis (CST) and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone and heart, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and hearing/vestibular/ear.

Disease Ontology:11 A tooth disease characterized by failure to develop on or more missing teeth.

Related Diseases for Tooth Agenesis

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Diseases related to Tooth Agenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1tooth agenesis, selective, 1, with or without orofacial cleft12.3
2tooth agenesis, selective, 412.2
3tooth agenesis, selective, 312.2
4tooth agenesis, selective, x-linked 112.2
5tooth agenesis, selective, 712.2
6tooth agenesis, selective, 812.2
7leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism12.2
8leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism12.1
9dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis12.1
10tooth agenesis, selective, 211.9
11tooth agenesis, selective, 511.8
12hypodontia, x-linked11.8
13microdontia hypodontia short stature11.8
14epidermolysis bullosa simplex with anodontia/hypodontia11.8
15leukomelanoderma, infantilism, mental retardation, hypodontia, hypotrichosis11.7
16congenital heart disease ptosis hypodontia craniostosis11.7
17hypodontia of incisors and premolars11.7
18oligodontia-colorectal cancer syndrome11.4
19dental anomalies and short stature11.1
20ectodermal dysplasia, ectrodactyly, and macular dystrophy10.8
21deafness, congenital, and onychodystrophy, autosomal dominant10.8
22ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.7EDAR, EDARADD
23walker dyson syndrome10.7EDAR, EDARADD, WNT10A
24idh3b-related retinitis pigmentosa10.7EDAR, EDARADD
25pertussis10.7EDA, EDAR, EDARADD
26scleroperikeratitis10.7EDA, EDAR, EDARADD
27dementia, familial british10.6EDA, EDAR, EDARADD, WNT10A
28ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive10.6EDAR, EDARADD
29auriculocondylar syndrome 310.6BMP4, DSP, IRF6, MSX1
30neuroschistosomiasis10.6AXIN2, EDA, EDARADD, MSX1, PAX9
31syphilitic myelopathy10.6BMP4, FGFR1, TGFB3
32ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.6EDAR, EDARADD
33emery-dreifuss muscular dystrophy, x-linked10.6EDA, EDAR, EDARADD
34fallopian tube disease10.5IRF6, WNT10A
35frontotemporal dementia, right temporal atrophy variant10.5DSP, TGFB3
36ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.5EDA, EDAR, EDARADD, MSX1, PAX9, WNT10A
37ectrodactyly cardiopathy dysmorphism10.4FGFR1, SUMO1, WNT10B
38fixed pigmented erythema10.4DSP, TGFB3
39myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency10.4BMP4, FGFR1, IRF6, MSX1, TGFA, TGFB3
40ketamine-induced biliary dilatation10.3DSP, TGFB3
41myocardium cancer10.2BMP4, FGFR1, IRF6, MSX1, SUMO1, TGFA
42cleft lip10.0
43orofacial cleft10.0
44down syndrome10.0
45ectodermal dysplasia9.9
46colorectal cancer9.8
47taurodontism9.8
48velocardiofacial syndrome9.7
49myelomeningocele9.7
50heart disease9.7

Graphical network of the top 20 diseases related to Tooth Agenesis:



Diseases related to tooth agenesis

Symptoms & Phenotypes for Tooth Agenesis

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Human phenotypes related to Tooth Agenesis:

 64 54 (show all 11)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 taurodontia64 hallmark (90%) HP:0000679
2 abnormality of dental enamel64 hallmark (90%) HP:0000682
3 delayed eruption of teeth64 hallmark (90%) HP:0000684
4 dental malocclusion64 hallmark (90%) HP:0000689
5 reduced number of teeth64 hallmark (90%) HP:0009804
6 micrognathia64 54 hallmark (90%) Very frequent (99-80%) HP:0000347
7 microdontia64 54 hallmark (90%) Very frequent (99-80%) HP:0000691
8 abnormality of the face54 Very frequent (99-80%)
9 hypoplasia of the maxilla54 Very frequent (99-80%)
10 oligodontia54 Very frequent (99-80%)
11 abnormality of dental morphology54 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Tooth Agenesis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-5810.2AXIN2, LRP6, WNT10B

MGI Mouse Phenotypes related to Tooth Agenesis according to GeneCards Suite gene sharing:

41 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.2BMP4, EDARADD, FGF3, FGFR1, IRF6, LRP6
2MP:000538810.1BMP4, EDARADD, LRP6, MSX1, PAX9, PITX2
3MP:000301210.0AXIN2, BMP4, FGF3, FGFR1, LRP6, MSX1
4MP:00053799.9AXIN2, BMP4, EDAR, EDARADD, FGFR1, MSX1
5MP:00053699.9BMP4, COL1A2, DSP, FGFR1, MSX1, PAX9
6MP:00053899.9AXIN2, BMP4, EDARADD, FGF3, FGFR1, LRP6
7MP:00053809.8AXIN2, BMP4, DSP, FGF3, FGFR1, IRF6
8MP:00053919.7AXIN2, BMP4, EDAR, EDARADD, FGFR1, LRP6
9MP:00107719.6BMP4, COL1A2, DSP, EDAR, EDARADD, FGFR1
10MP:00028739.6AXIN2, BMP4, COL1A2, FGF3, FGFR1, LRP6
11MP:00053849.5AXIN2, BMP4, COL1A2, DSP, EDAR, FGFR1
12MP:00053869.5BMP4, COL1A2, EDARADD, FGF3, FGFR1, LRP6
13MP:00053859.5AXIN2, BMP4, COL1A2, DSP, FGFR1, MSX1
14MP:00053909.4AXIN2, BMP4, COL1A2, FGF3, FGFR1, IRF6
15MP:00036319.4AXIN2, BMP4, DSP, EDARADD, FGF3, FGFR1
16MP:00053719.4AXIN2, BMP4, COL1A2, EDAR, EDARADD, FGF3
17MP:00053829.1AXIN2, BMP4, DSP, EDAR, EDARADD, FGFR1
18MP:00053819.1BMP4, DSP, EDAR, FGFR1, IRF6, LRP6
19MP:00107689.0AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD
20MP:00053788.6AXIN2, BMP4, COL1A2, DSP, EDAR, EDARADD

Drugs & Therapeutics for Tooth Agenesis

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Drugs for Tooth Agenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 311237439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
Deferasiroxapproved, investigationalPhase 389201530-41-85493381
Synonyms:
Deferasiroxum
Deferasiroxum [inn-latin]
 
Exjade
ICL 670
ICL 670a
deferasirox
3Trace ElementsPhase 35802
4MicronutrientsPhase 35802
5Iron Chelating AgentsPhase 3222
6Chelating AgentsPhase 31365
7OrangeNutraceuticalPhase 3249

Interventional clinical trials:

idNameStatusNCT IDPhase
1Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadCompletedNCT00235391Phase 3
2Linkage and Identification of (a) Candidate Gene(s) for Tooth DisordersUnknown statusNCT00026026
3Hypodontia and Ovarian CancerUnknown statusNCT01470235
4Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue GrowthCompletedNCT02740907
5Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral TinnitusRecruitingNCT02630589
6Study of Selected X-Linked Disorders: Aicardi SyndromeRecruitingNCT00697411
7Clinical and Genetic Studies on HoloprosencephalyRecruitingNCT00088426
8Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168

Search NIH Clinical Center for Tooth Agenesis


Cochrane evidence based reviews: anodontia

Genetic Tests for Tooth Agenesis

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Genetic tests related to Tooth Agenesis:

id Genetic test Affiliating Genes
1 Hypodontia27
2 Selective Tooth Agenesis27
3 Oligodontia27

Anatomical Context for Tooth Agenesis

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MalaCards organs/tissues related to Tooth Agenesis:

36
Bone, Heart

Publications for Tooth Agenesis

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Articles related to Tooth Agenesis:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Prevalence of delayed tooth development and its relation to tooth agenesis in Korean children. (27810381)
2017
2
Tooth agenesis and orofacial clefting: genetic brothers in arms? (27699475)
2016
3
Functional analysis of a novel missense mutation in AXIN2 associated with non-syndromic tooth agenesis. (27090353)
2016
4
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. (26759063)
2016
5
Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis. (27311636)
2016
6
A novel heterozygous mutation in desmoplakin gene in a Lebanese patient with Carvajal syndrome and tooth agenesis. (26833927)
2016
7
Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. (27144394)
2016
8
Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis. (27665865)
2016
9
Permanent tooth agenesis in non-syndromic Robin sequence and cleft palate: prevalence and patterns. (27933446)
2016
10
Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis. (27362534)
2016
11
Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis. (26963285)
2016
12
Clinical and Radiographic Evaluation of a Small-Diameter Dental Implant Used for the Restoration of Patients with Permanent Tooth Agenesis (Hypodontia) in the Maxillary Lateral Incisor and Mandibular Incisor Regions: A 36-Month Follow-Up. (26929953)
2016
13
Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. (27365112)
2016
14
Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis. (27464525)
2016
15
Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis. (27895972)
2016
16
Tooth agenesis in osteogenesis imperfecta related to mutations in the collagen type I genes. (27510842)
2016
17
Prevalence of Tooth Agenesis in Adolescent Chinese Populations with or without Orthodontics. (25815384)
2015
18
Retrospective Study of Association between Displacement of Maxillary Canine and Tooth Agenesis. (26551375)
2015
19
An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family. (26030286)
2015
20
Permanent Tooth Agenesis and Maxillary Hypoplasia in Patients with Unilateral Cleft Lip and Palate. (26505722)
2015
21
Prevalence and distribution of dental anomalies: A comparison between maxillary and mandibular tooth agenesis. (26522039)
2015
22
Association of BMP4 polymorphisms with isolated tooth agenesis in a Chinese Han population: a case-control study. (26166641)
2015
23
Prevalence and patterns of tooth agenesis in Angle Class II Division 2 malocclusion in Japan. (26124035)
2015
24
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population. (26707046)
2015
25
WNT10A variants are associated with non-syndromic tooth agenesis in the general population. (24043634)
2014
26
Colorectal cancer and self-reported tooth agenesis. (24607150)
2014
27
Is there a link between ovarian cancer and tooth agenesis? (24631698)
2014
28
Prevalence and patterns of tooth agenesis among Malay children. (24968691)
2014
29
Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population. (24737523)
2014
30
Whole genome sequencing reveals novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis. (25203534)
2014
31
Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study. (25041097)
2014
32
A study of prevalence and distribution of tooth agenesis. (25713620)
2014
33
Characterization of novel MSX1 mutations identified in Japanese patients with nonsyndromic tooth agenesis. (25101640)
2014
34
The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. (24700731)
2014
35
Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis. (24436340)
2014
36
Prevalence and patterns of permanent tooth agenesis in patients with nonsyndromic Pierre Robin sequence. (24703283)
2014
37
Mutations in the MSX1 gene in Turkish children with non-syndromic tooth agenesis and other dental anomalies. (25565750)
2014
38
The impact of tooth agenesis on oral health-related quality of life in children. (23794692)
2013
39
rs929387 of GLI3 is involved in tooth agenesis in Chinese Han population. (24278334)
2013
40
Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees. (23598609)
2013
41
PAX9 Polymorphisms and susceptibility with sporadic tooth agenesis in Turkish populations: a case-control study. (24160254)
2013
42
Complex analysis of multiple single nucleotide polymorphisms as putative risk factors of tooth agenesis in the Hungarian population. (23964635)
2013
43
Genetics of tooth agenesis: how to move the field forward. (23857660)
2013
44
A comparison of skeletal maturation in patients with tooth agenesis and unaffected controls assessed by the cervical vertebral maturation (CVM) index. (24297960)
2013
45
Novel missense mutation in PAX9 gene associated with familial tooth agenesis. (22747565)
2013
46
Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population. (24312213)
2013
47
A 3-year prospective study of implant-supported, single-tooth restorations of all-ceramic and metal-ceramic materials in patients with tooth agenesis. (22708959)
2013
48
Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients. (23718693)
2013
49
Genetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population. (24351915)
2013
50
Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation. (23841782)
2013

Variations for Tooth Agenesis

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Clinvar genetic disease variations for Tooth Agenesis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1WNT10ANM_025216.2(WNT10A): c.637G> A (p.Gly213Ser)SNVPathogenicrs147680216GRCh37Chr 2, 219754966: 219754966
2WNT10ANM_025216.2(WNT10A): c.682T> A (p.Phe228Ile)SNVPathogenicrs121908120GRCh37Chr 2, 219755011: 219755011

Expression for genes affiliated with Tooth Agenesis

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Search GEO for disease gene expression data for Tooth Agenesis.

Pathways for genes affiliated with Tooth Agenesis

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GO Terms for genes affiliated with Tooth Agenesis

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Cellular components related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:000561510.3BMP4, COL1A2, MMP20, TGFA, TGFB3, WNT10A
2extracellular regionGO:000557610.1BMP4, COL1A2, EDA, FGF3, FGFR1, LRP6
3proteinaceous extracellular matrixGO:000557810.0BMP4, MMP20, WNT10A, WNT10B

Biological processes related to Tooth Agenesis according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1neural crest cell differentiationGO:001403311.1LRP6, WNT10A
2BMP signaling pathway involved in heart developmentGO:006131211.0BMP4, MSX1
3epithelial to mesenchymal transition involved in endocardial cushion formationGO:000319811.0BMP4, MSX1
4organ inductionGO:000175911.0BMP4, FGFR1
5deltoid tuberosity developmentGO:003599311.0BMP4, PITX2
6positive regulation of ossificationGO:004577811.0BMP4, WNT10B
7positive regulation of SMAD protein import into nucleusGO:006039111.0BMP4, TGFB3
8cell fate commitmentGO:004516511.0BMP4, WNT10A, WNT10B
9regulation of odontogenesisGO:004248110.9MSX1, PAX9
10embryonic limb morphogenesisGO:003032610.9BMP4, FGFR1, MSX1
11chondrocyte differentiationGO:000206210.9BMP4, FGFR1, WNT10B
12embryonic hindlimb morphogenesisGO:003511610.9BMP4, MSX1, PITX2
13salivary gland cavitationGO:006066210.9EDA, EDAR
14regulation of odontogenesis of dentin-containing toothGO:004248710.9BMP4, WNT10A
15positive regulation of bone mineralizationGO:003050110.9BMP4, TGFB3, WNT10B
16pituitary gland developmentGO:002198310.9BMP4, MSX1, PITX2
17secondary heart field specificationGO:000313910.9AXIN2, BMP4
18salivary gland morphogenesisGO:000743510.9FGFR1, TGFB3
19lung developmentGO:003032410.9BMP4, FGFR1, PITX2
20positive regulation of cell divisionGO:005178110.9FGF3, TGFA, TGFB3
21face morphogenesisGO:006032510.9LRP6, MSX1, PAX9, TGFB3
22positive regulation of canonical Wnt signaling pathwayGO:009026310.9AXIN2, EDA, LRP6, WNT10B
23palate developmentGO:006002110.8LRP6, MSX1, SUMO1, TGFB3
24in utero embryonic developmentGO:000170110.8FGFR1, MSX1, PITX2, TGFB3
25Wnt signaling pathway involved in somitogenesisGO:009024410.8AXIN2, LRP6
26positive regulation of gene expressionGO:001062810.8BMP4, EDA, EDAR, WNT10A
27negative regulation of cell proliferationGO:000828510.7AXIN2, BMP4, IRF6, MSX1, TGFB3
28skin developmentGO:004358810.7DSP, EDA, IRF6, WNT10A
29positive regulation of cell proliferationGO:000828410.7BMP4, FGF3, FGFR1, TGFA, WNT10B
30odontogenesis of dentin-containing toothGO:004247510.6BMP4, EDA, EDAR, LRP6, MSX1, PITX2
31positive regulation of transcription, DNA-templatedGO:004589310.5BMP4, IRF6, LRP6, PITX2, TGFB3
32Wnt signaling pathwayGO:001605510.5AXIN2, LRP6, PITX2, WNT10A, WNT10B
33positive regulation of transcription from RNA polymerase II promoterGO:004594410.4BMP4, LRP6, MSX1, PAX9, PITX2, TGFB3
34odontogenesisGO:004247610.4AXIN2, BMP4, COL1A2, MSX1, PAX9, PITX2
35wound healingGO:004206010.0BMP4, DSP, TGFA, TGFB3

Molecular functions related to Tooth Agenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:000510911.0LRP6, WNT10A, WNT10B
2growth factor activityGO:000808310.8BMP4, FGF3, TGFA, TGFB3
3protein bindingGO:00055158.5AXIN2, BMP4, COL1A2, DSP, EDA, EDAR

Sources for Tooth Agenesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet