Tooth Agenesis malady

MalaCards: Tooth Agenesis, also known as tooth agenesis, selective, is related to oligodontia and ectodermal dysplasia. An important gene associated with Tooth Agenesis is STHAG5 (tooth agenesis, selective, 5), and among its related pathways are 14-3-3 Induced Intracellular Signaling and p53 Mediated Apoptosis. The compounds batimastat and hydroxyapatite have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and skeleton.

Aliases & Descriptions:

tooth agenesis 6 8 tooth agenesis, selective 32 selective tooth agenesis 6

familial tooth agenesis 6 hypodontia/oligodontia 6

Diseases related to tooth agenesis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 81)

id	Related Disease	Score	Top Affiliating Genes
1	oligodontia	27.9	PAX9, EDARADD, EDA, LTBP3, DLX2, MSX1
2	ectodermal dysplasia	27.6	IRF6, MSX1, CDH3, TNF, DLX2, EDAR
3	orofacial cleft	27.5	CHDH, MSX1, CDH1, IRF6, TGFA, AXIN2
4	hypodontia	27.5	PAX9, MSX1, IRF6, HYD2, PITX2, LTBP3
5	hypohidrotic ectodermal dysplasia	13.3	EDARADD, EDAR, EDA
6	hypohidrosis	13.3	EDAR, EDA, EDARADD
7	anodontia	13.3	PITX2, AXIN2, EDARADD
8	ectrodactyly	13.2	CDH3, DLX5, FGF8
9	kallmann syndrome 1	13.2	KAL1, FGFR1
10	taurodontism	13.1	EDA, DSPP
11	hereditary diffuse gastric cancer	13.1	CDH1, CDH3
12	gonadotropin deficiency	13.0	PROK2, PROKR2, FGFR1, KAL1
13	craniofacial anomalies	13.0	MSX2, FGF8, ENAM, RUNX2
14	polydactyly	13.0	MNX1, MSX2, MSX1, BMP4, FGF8
15	syndactyly	13.0	DLX2, FGF8, FGFR1, MSX2
16	synostosis	13.0	BMP4, MSX1, FGFR1, MSX2
17	acrocephalosyndactylia	12.9	RUNX2, FGFR1, MSX2
18	birth defects	12.9	IRF6, TGFA, MSX1, BMP4
19	infectious mononucleosis	12.9	RUNX2, FGFR1, FGF8
20	amelia cleft lip palate hydrocephalus iris coloboma	12.9	IRF6, TGFA, FGFR1
21	saethre-chotzen syndrome	12.8	RUNX2, FGFR1, MSX2
22	dentinogenesis imperfecta	12.8	MSX1, ENAM, MMP20, DSPP
23	delayed puberty	12.8	FGFR1, CHD7, KAL1
24	cleidocranial dysplasia	12.8	MSX2, TGFA, RUNX2
25	ankylosis	12.7	DLX2, FGFR1, DSPP
26	amelogenesis imperfecta	12.6	DSPP, ENAM, MMP20, MSX2, MSX1
27	pediatric cns embryonal cell carcinoma	12.6	FGFR1, FGF8, MSX2, BMP4
28	dentin dysplasia	12.5	MMP20, DSPP, ENAM, MSX2, PAX9, MSX1
29	craniosynostosis	12.5	MSX2, FGF8, DLX5, RUNX2, FGFR1
30	anosmia	12.5	KAL1, FGF8, FGFR1, PROK2, PROKR2, CHD7
31	renal agenesis	12.5	PROKR2, KAL1, PROK2, FGFR1, FGF8, CHD7
32	kallmann syndrome	12.5	FGFR1, FGF8, CHD7, KAL1, PROKR2, PROK2
33	hypogonadotropism	12.5	CHD7, PROK2, PROKR2, FGFR1, FGF8, KAL1
34	hypotrichosis	12.5	EDARADD, DSPP, CDH3, EDA, EDAR
35	polycystic kidney disease	12.3	MSX2, ENAM, TNF, ANKS6, TGFA
36	mayer-rokitansky-kuster-hauser syndrome	12.2	KAL1, BMP4, FGFR1, EDA, EDARADD, RUNX2
37	twinning	12.1	CHD7, PAX9, IRF6, EDAR, EDA, TNF
38	klinefelter's syndrome	12.0	FGFR1, TNF, PROK2, PROKR2, CHD7, KAL1
39	hypogonadism	12.0	PROKR2, PROK2, TNF, FGFR1, CHD7, KAL1
40	fasciitis	11.9	PITX2, TNF, MMP1
41	pulpitis	11.9	DSPP, TNF, MMP1
42	oral submucous fibrosis	11.9	TGFA, TNF, MMP1
43	chordoma	11.8	CDH3, CDH1, MMP1, TGFA
44	pituitary adenoma	11.7	BMP4, CDH1, FGFR1, PITX2, TGFA, CDH3
45	cerebellar hypoplasia	11.7	CHD7, BMP4, KAL1, RUNX2, DSPP, PITX2
46	prostate cancer, progression of	11.6	CDH1, FGFR1, FGF8, CDH3, MMP1
47	oral lichen planus	11.5	MMP1, TNF, BMP4, CDH1
48	cutaneous malignant melanoma	11.3	MMP1, TNF, CDH1, TGFA, CDH3
49	boomerang dysplasia	11.3	CDH3, CDH1, DSPP, TGFA, RUNX2, CHD7
50	glaucoma	11.2	MMP1, CDH1, TNF, LTBP3, BMP4, PITX2

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to tooth agenesis:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	8.3	EDARADD, DLX5, DLX2, FGFR1, FGF8, IRF6
2	skeleton phenotype	MP:0005390	8.0	RUNX2, TGFA, EDA, LTBP3, PITX2, FGFR1
3	respiratory system phenotype	MP:0005388	7.8	DLX5, PITX2, EDA, EDARADD, RUNX2, DLX2
4	muscle phenotype	MP:0005369	7.3	RUNX2, TGFA, PITX2, DLX5, DLX2, TNF
5	behavior/neurological phenotype	MP:0005386	7.1	TNF, DLX2, DLX5, LTBP3, EDARADD, PROKR2
6	embryogenesis phenotype	MP:0005380	7.1	PITX2, DLX5, TNF, FGFR1, FGF8, CDH1
7	vision/eye phenotype	MP:0005391	6.9	PITX2, LTBP3, EDA, EDARADD, TGFA, RUNX2
8	limbs/digits/tail phenotype	MP:0005371	6.8	TNF, DLX5, PITX2, EDA, EDAR, EDARADD
9	cellular phenotype	MP:0005384	6.7	RUNX2, PROKR2, EDAR, PITX2, DLX5, FGFR1
10	immune system phenotype	MP:0005387	6.7	TNF, PITX2, LTBP3, EDA, TGFA, FGFR1
11	integument phenotype	MP:0010771	6.6	EDA, EDAR, EDARADD, TGFA, PROKR2, RUNX2
12	nervous system phenotype	MP:0003631	6.5	DLX5, PITX2, EDA, EDARADD, PROK2, PROKR2
13	reproductive system phenotype	MP:0005389	6.3	TNF, PITX2, EDA, EDARADD, TGFA, PROKR2
14	cardiovascular system phenotype	MP:0005385	6.3	TNF, DLX2, DLX5, PITX2, EDA, TGFA
15	digestive/alimentary phenotype	MP:0005381	6.0	TNF, DLX2, DLX5, PITX2, EDA, EDAR
16	endocrine/exocrine gland phenotype	MP:0005379	5.7	TNF, PITX2, EDA, EDAR, EDARADD, TGFA
17	growth/size phenotype	MP:0005378	5.6	DLX2, DLX5, PITX2, LTBP3, EDA, EDARADD
18	mortality/aging	MP:0010768	5.5	TNF, DLX2, DLX5, PITX2, EDA, EDAR
19	craniofacial phenotype	MP:0005382	5.4	BMP4, DLX5, PITX2, LTBP3, EDA, EDAR

Articles related to tooth agenesis:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	MMP1 and MMP20 contribute to tooth agenesis in humans . (21144496)	KA1chler E.C.... Vieira A.R.	2011	MMP1, MMP20
2	Functional analysis of Ectodysplasin-A mutations caus ing selective tooth agenesis. (19623212)	Mues G.... D'Souza R.N.	2010	EDA
3	Msh homebox-1 polymorphisms and susceptibility to 19 8 sporadic tooth agenesis: a case-control study (20450679)	Wang H.... Zhang W.B.	2010	MSX1
4	Transforming growth factor-alfa gene (TGFA), human tooth agenesis, and evidence of segmental uniparental isodisomy. (19196314)	Callahan N.... Vieira A.R.	2009	TNF, TGFA
5	From ectodermal dysplasia to selective tooth agenesis . (19504606)	Mues G.I.... D'Souza R.	2009	EDA, EDAR, EDARADD
6	Pathogenic mechanisms of tooth agenesis linked to pai red domain mutations in human PAX9. (19429910)	Wang Y.... Kapadia H.	2009	PAX9, MSX1
7	Genetic basis of tooth agenesis. (19219933)	Nieminen P.	2009	PAX9, MSX1
8	Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. (18790474)	Callahan N.... Vieira A.R.	2009	AXIN2, PAX9
9	Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis. (18657636)	Han D.... Song S.	2008	PAX9, MSX1, EDA
10	Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish population. (18452891)	Vieira A.R.... Menezes R.	2008	IRF6
11	Investigating the etiology of multiple tooth agenesis in three sisters with severe oligodontia. (18199077)	Swinnen S.... Carels C.	2008	PAX9, MSX1, DLX2
12	Non-syndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of EDA (ectodysplasin A). (18545687)	Li S.... Hua Z.C.	2008	EDA
13	AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts. (18683894)	Letra A.... Vieira A.R.	2008	CDH1, AXIN2
14	PAX9 polymorphisms and susceptibility to sporadic tooth agenesis: a case-control study in southeast China. (18353002)	Pan Y.... Huang Y.	2008	PAX9
15	Research advances in tooth agenesis (17304318)	Feng H.L.... Wu H.	2007	RUNX2, PITX2
16	The role of MSX1 in tooth agenesis in Iranians. (17559452)	Seifi M.... Golkar P.	2007	MSX1
17	Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis. (17318851)	Vieira A.R.... Murray J.C.	2007	FGFR1, IRF6
18	Molecular characterization of a novel PAX9 missense mutation causing posterior tooth agenesis. (16479262)	Kapadia H.... D'Souza R.N.	2006	PAX9, MSX1
19	Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis. (16432638)	Mostowska A.... Jagodzinski P.P.	2006	AXIN2, PAX9, MSX1
20	Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans. (14607846)	Mensah J.K.... D'Souza R.N.	2004	PAX9
21	MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. (15329380)	Vieira A.R.... Murray J.C.	2004	TGFA, PAX9
22	Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. (15042511)	Lammi L.... Nieminen P.	2004	AXIN2
23	Molecular basis of non-syndromic tooth agenesis: mutations of MSX1 and PAX9 reflect their role in patterning human dentition. (12974677)	Mostowska A.... Trzeciak W.H.	2003	PAX9, MSX1
24	The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). (14630903)	Gao Y.... Ganss B.	2003	ZNF22
25	The role of MSX1 in human tooth agenesis. (12097313)	Lidral A.C.... Reising B.C.	2002	MSX1
26	Concomitant occurrence of canine malposition and tooth agenesis: evidence of orofacial genetic fields. (12490878)	Peck S.... Kataja M.	2002	PAX9, MSX1
27	The novel polymorphic variants within the paired box of the PAX9 gene are associated with selective tooth agenesis. (11374781)	Kobielak A.... Trzeciak W.H.	2001	PAX9
28	MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. (10742093)	van den Boogaard M.J.... van Amstel H.K.	2000	MSX1
29	Haploinsufficiency of MSX1: a mechanism for selective tooth agenesis. (9742121)	Hu G.... Abate-Shen C.	1998	MSX1
30	A human MSX1 homeodomain missense mutation causes selective tooth agenesis. (8696335)	Vastardis H.... Seidman C.E.	1996	MSX1

Genes related to tooth agenesis according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	STHAG5	tooth agenesis, selective, 5	11.1	Aliases & Descriptions
2	MSX1	msh homeobox 1	11.0	Publications
3	PAX9	paired box 9	11.0	Publications
4	HYD2	hypodontia, autosomal recessive (2)	11.0
5	LTBP3	latent transforming growth factor beta binding protein 3	11.0
6	EDA	ectodysplasin A	11.0	Publications
7	WNT8A	wingless-type MMTV integration site family, member 8A	11.0
8	AXIN2	axin 2	11.0	Publications
9	ZNF22	zinc finger protein 22	11.0	Publications
10	DLX2	distal-less homeobox 2	11.0	Publications
11	PROK2	prokineticin 2	11.0
12	MNX1	motor neuron and pancreas homeobox 1	11.0
13	IRF6	interferon regulatory factor 6	11.0	Publications
14	PROKR2	prokineticin receptor 2	11.0
15	ENAM	enamelin	11.0
16	MMP20	matrix metallopeptidase 20	11.0	Publications, Disorders
17	ANKS6	ankyrin repeat and sterile alpha motif domain containing 6	11.0
18	FGF8	fibroblast growth factor 8 (androgen-induced)	11.0
19	CHDH	choline dehydrogenase	11.0
20	DLX5	distal-less homeobox 5	11.0
21	MSX2	msh homeobox 2	11.0
22	KAL1	Kallmann syndrome 1 sequence	11.0
23	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0
24	PITX2	paired-like homeodomain 2	11.0	Publications
25	EDAR	ectodysplasin A receptor	11.0	Publications
26	EDARADD	EDAR-associated death domain	11.0	Publications
27	MSRB3	methionine sulfoxide reductase B3	11.0	Disorders
28	CHD7	chromodomain helicase DNA binding protein 7	11.0
29	BMP4	bone morphogenetic protein 4	11.0
30	TGFA	transforming growth factor, alpha	11.0	Publications
31	RUNX2	runt-related transcription factor 2	11.0	Publications
32	DPF3	D4, zinc and double PHD fingers, family 3	11.0
33	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
34	DSPP	dentin sialophosphoprotein	11.0
35	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
36	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
37	TNF	tumor necrosis factor	11.0	Publications

Pathways related to tooth agenesis according to GeneDecks:

(show all 36)

id	Pathway	Score	Top Affiliating Genes
1	14-3-3 Induced Intracellular Signaling36	9.7	LTBP3, TNF, FGF8, BMP4
2	p53 Mediated Apoptosis36	9.4	TGFA, LTBP3, FGFR1, FGF8, BMP4
3	Telomerase Components in Cell Signaling36	9.4	TGFA, LTBP3, FGFR1, FGF8, BMP4
4	Mitochondrial Apoptosis36	9.4	TGFA, LTBP3, FGFR1, FGF8, BMP4
5	DHA Signaling36	9.4	TGFA, LTBP3, FGFR1, FGF8, BMP4
6	ERK5 Signaling36	9.3	TGFA, LTBP3, FGFR1, FGF8, BMP4
7	eIF2 Pathway36	9.3	TGFA, LTBP3, FGFR1, FGF8, BMP4
8	Nuclear Receptor Activation by Vitamin-A36	9.3	TGFA, LTBP3, FGFR1, FGF8, BMP4
9	Nanog in Mammalian ESC Pluripotency36	9.3	WNT8A, TGFA, LTBP3, FGFR1, FGF8, BMP4
10	Rac1 Pathway36	9.3	BMP4, FGF8, FGFR1, LTBP3, TGFA
11	Actin-Based Motility by Rho Family GTPases36	9.3	TGFA, LTBP3, FGFR1, FGF8, BMP4
12	p70S6K Signaling36	9.2	BMP4, FGF8, FGFR1, LTBP3, TGFA
13	IP3 Pathway36	9.2	TGFA, LTBP3, FGFR1, FGF8, BMP4
14	Activation of PKC through GPCR36	9.2	TGFA, LTBP3, FGFR1, FGF8, BMP4
15	Paxillin Interactions36	9.2	BMP4, FGF8, FGFR1, LTBP3, TGFA
16	Renin-Angiotensin Pathway36	9.1	TGFA, LTBP3, FGFR1, FGF8, BMP4
17	Rap1 Pathway36	9.0	BMP4, FGF8, FGFR1, LTBP3, TGFA
18	Ras Pathway36	8.9	TGFA, LTBP3, FGFR1, FGF8, BMP4
19	Apoptotic Pathways in Synovial Fibroblasts36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
20	NF-KappaB (p50-p65) Pathway36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
21	NF-KappaB Family Pathway36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
22	Cellular Apoptosis Pathway36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
23	PPAR Pathway36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
24	PAK Pathway36	8.9	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
25	MAPK Family Pathway36	8.8	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
26	Tec Kinases Signaling36	8.8	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
27	TGF-Beta Pathway36	8.8	TGFA, LTBP3, FGFR1, FGF8, CDH1, BMP4
28	Epithelial Adherens Junctions36	8.8	TGFA, LTBP3, FGFR1, FGF8, CDH1, BMP4
29	Colorectal Cancer Metastasis36	8.6	WNT8A, TNF, MMP1, CDH1, AXIN2
30	p38 Signaling36	8.5	BMP4, FGF8, FGFR1, TNF, LTBP3, TGFA
31	GSK3 Signaling36	8.5	BMP4, WNT8A, TGFA, LTBP3, FGFR1, FGF8
32	Pancreatic Adenocarcinoma36	8.5	TGFA, LTBP3, FGFR1, FGF8, MMP20, MMP1
33	Antioxidant Action of Vitamin-C36	8.2	TGFA, LTBP3, TNF, FGFR1, FGF8, BMP4
34	ILK Signaling36	8.1	TGFA, LTBP3, TNF, FGFR1, FGF8, CDH1
35	Rho Family GTPases36	8.1	TGFA, LTBP3, TNF, FGFR1, FGF8, CDH1
36	Pathways in cancer20	7.9	WNT8A, TGFA, FGFR1, FGF8, MMP1, CDH1

Compounds related to tooth agenesis according to GeneDecks:

(show all 16)

id	Compound	Score	Top Affiliating Genes
1	batimastat32 42 9 9	12.1	MMP1, MMP20, TGFA
2	hydroxyapatite32	9.0	RUNX2, DSPP, ENAM, CDH1
3	alendronate32 9 9	10.9	MMP1, DSPP, RUNX2
4	retinoid32	8.3	RUNX2, FGF8, MMP1, CDH1, BMP4
5	ribonucleic acid32	8.2	RUNX2, TGFA, FGFR1, MMP1, BMP4
6	ly29400232	8.1	RUNX2, TGFA, TNF, FGFR1, CDH1, BMP4
7	calcitriol32 42 9 18 9	11.9	TGFA, DSPP, TNF, MMP1, CDH1
8	ascorbic acid32 18	8.8	RUNX2, TGFA, DSPP, MMP1, BMP4
9	tgf beta132	7.8	BMP4, CDH1, MMP1, TNF, TGFA, RUNX2
10	sb 20358032 42	8.6	RUNX2, TNF, FGFR1, MMP1, CDH1, BMP4
11	pge232	7.5	RUNX2, TGFA, TNF, MMP1, CDH1, BMP4
12	pd 98,05932	7.3	RUNX2, TGFA, TNF, FGFR1, MMP1, CDH1
13	lactate32	7.1	TGFA, DSPP, TNF, FGFR1, MMP1, CDH1
14	vegf32	7.1	RUNX2, PROK2, TGFA, TNF, FGFR1, MMP1
15	retinoic acid32 42 18	8.8	RUNX2, TGFA, TNF, FGFR1, FGF8, MMP1
16	serine32	6.1	RUNX2, TGFA, DSPP, PITX2, TNF, FGFR1

Cellular components related to tooth agenesis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	8.1	BMP4, KAL1, MMP1, MMP20, ENAM, DSPP

Biological processes related to tooth agenesis according to GeneDecks:

(show all 28)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of odontogenesis	GO:042481	10.5	MSX1, PAX9
2	BMP signaling pathway involved in heart development	GO:061312	10.5	MSX2, MSX1
3	embryonic nail plate morphogenesis	GO:035880	10.4	MSX2, MSX1
4	trachea gland development	GO:061153	10.4	EDARADD, EDA
5	amelogenesis	GO:097186	10.4	ENAM, MMP20
6	epithelial to mesenchymal transition involved in endocardial cushion formation	GO:003198	10.3	FGF8, MSX2, MSX1
7	face morphogenesis	GO:060325	10.3	DLX5, MSX1, PAX9
8	signal transduction involved in regulation of gene expression	GO:023019	10.3	MSX1, MSX2, FGF8
9	deltoid tuberosity development	GO:035993	10.1	PITX2, BMP4
10	positive regulation of BMP signaling pathway	GO:030513	10.1	BMP4, MSX1, MSX2
11	palate development	GO:060021	10.1	CHD7, MSX1, DLX5, WNT8A
12	regulation of odontogenesis of dentin-containing tooth	GO:042487	10.1	FGF8, BMP4
13	positive regulation of NF-kappaB import into nucleus	GO:042346	9.9	EDAR, EDA, TNF
14	salivary gland cavitation	GO:060662	9.8	CDH1, EDA, EDAR
15	embryonic hindlimb morphogenesis	GO:035116	9.8	PITX2, FGF8, MSX2, MSX1, BMP4
16	cellular response to growth factor stimulus	GO:071363	9.7	BMP4, PAX9, MSX2
17	osteoblast differentiation	GO:001649	9.7	RUNX2, DLX5, MSX2, BMP4
18	cranial suture morphogenesis	GO:060363	9.6	MSX2, BMP4
19	odontogenesis of dentin-containing tooth	GO:042475	9.6	EDARADD, EDAR, EDA, DLX2, MSX1, BMP4
20	regulation of branching involved in salivary gland morphogenesis	GO:060693	9.6	TNF, CDH1
21	positive regulation of mitosis	GO:045840	9.6	TGFA, TNF, FGF8
22	odontogenesis	GO:042476	9.6	ZNF22, PITX2, ENAM, FGF8, AXIN2, PAX9
23	inner ear morphogenesis	GO:042472	9.5	CHD7, FGFR1, DLX5
24	MAPK cascade	GO:000165	9.3	TGFA, TNF, FGFR1, FGF8
25	negative regulation of cell proliferation	GO:008285	9.2	TNF, IRF6, MSX2, MSX1, AXIN2, BMP4
26	skeletal system development	GO:001501	9.0	DSPP, DLX5, FGFR1, CHD7
27	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.9	PITX2, DLX5, DLX2, TNF, MSX1, PAX9
28	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.8	PITX2, DLX2, TNF, FGFR1, MSX2, MSX1