MCID: TTH006
MIFTS: 46

Tooth Disease malady

Gastrointestinal diseases category

Summaries for Tooth Disease

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MedlinePlus:32 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards based summary: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease, type 1a and neuropathy, congenital hypomyelinating. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The drugs camphor and camphor oil and the compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Tooth Disease

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Tooth Disease, Aliases & Descriptions:

Name: Tooth Disease 9
Dental Disorder 9 43
Tooth Disorders 32
 
Dental Diseases 60
Tooth Diseases 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:1091
MeSH33 D014076
NCIt38 C35077
ICD1025 K02.9

Related Diseases for Tooth Disease

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Diseases related to Tooth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease, type 1a32.0PMP22, MPZ
2neuropathy, congenital hypomyelinating31.2MPZ, EGR2
3roussy-levy syndrome30.7MPZ, PMP22
4dejerine-sottas disease30.6EGR2, GJB1, MPZ, PMP22
5hereditary neuropathies30.6GJB1, MTMR2, MPZ, PMP22
6pelizaeus-merzbacher disease30.4MPZ
7polyneuropathy30.4PMP22, MPZ, GJB1, EGR2
8charcot-marie-tooth disease30.2GDAP1, MFN2, PMP22, HSPB1, MPZ, NEFL
9neuritis30.1PMP22, MPZ
10axonal neuropathy30.0KIF1B, HSPB1
11sensorineural hearing loss29.9PMP22, GJB1
12charcot-marie-tooth neuropathy type 129.8PMP22, MPZ, NEFL, EGR2
13charcot-marie-tooth disease, type 2e29.7GDAP1, MFN2, HSPB8, HSPB1, MPZ, NEFL
14neuropathy29.6GDAP1, MFN2, PMP22, HSPB8, MPZ, NEFL
15myopathy27.8EGR2, GJB1, MTMR2, GDAP1, MFN2, PMP22
16charcot-marie-tooth disease, type 1b10.7
17charcot-marie-tooth disease, type 1e10.6
18charcot-marie-tooth disease, type 2b10.6
19charcot-marie-tooth disease, type 2d10.5
20charcot-marie-tooth disease, type 2b210.5
21charcot-marie-tooth disease, type 2b110.5
22charcot-marie-tooth disease, type 2j10.5
23charcot-marie-tooth disease, type 1d10.5
24charcot-marie-tooth disease type 2g10.5
25charcot-marie-tooth disease, type 4c10.5
26charcot-marie-tooth disease, type 4a10.5
27charcot-marie-tooth disease, type 4b110.5
28charcot-marie-tooth disease, type 1c10.5
29charcot-marie-tooth disease type 2a10.5
30charcot-marie-tooth disease type 2f10.5
31charcot-marie-tooth disease x-linked 110.5
32charcot-marie-tooth disease, type 2i10.5
33charcot-marie-tooth disease type 2h10.5
34charcot-marie-tooth disease type 2c10.5
35charcot-marie-tooth disease type 2k10.5
36neuropathy, recurrent, with pressure palsies10.5PMP22
37charcot-marie-tooth disease, type 1f10.5
38charcot-marie-tooth disease, type 4b210.4
39charcot-marie-tooth neuropathy, x-linked recessive, 210.4
40charcot-marie-tooth neuropathy, x-linked recessive, 310.4
41hereditary neuropathy with liability to pressure palsy10.4
42x-linked charcot-marie-tooth disease type 510.4
43autosomal dominant intermediate charcot-marie-tooth disease type e10.4
44polyradiculoneuropathy10.4PMP22
45charcot-marie-tooth disease, type 4d10.4
46charcot-marie-tooth disease, type 4h10.4
47hereditary motor and sensory neuropathy v10.4
48charcot-marie-tooth disease, type 2a110.4
49charcot-marie-tooth disease, type 2a210.3
50charcot-marie-tooth disease dominant intermediate 110.3

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Symptoms for Tooth Disease

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Drugs & Therapeutics for Tooth Disease

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Drug clinical trials:

Search ClinicalTrials for Tooth Disease

Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS60/NDF-RT39:

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Genetic Tests for Tooth Disease

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Anatomical Context for Tooth Disease

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MalaCards organs/tissues related to Tooth Disease:

31
Testes, Bone, Brain, Spinal cord, Skeletal muscle

Animal Models for Tooth Disease or affiliated genes

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MGI Mouse Phenotypes related to Tooth Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2EGR2, MTMR2, NEFL, HSPB1, MFN2
2MP:00053867.5MFN2, PMP22, MPZ, MTMR2, KIF1B, GJB1
3MP:00036317.2EGR2, MFN2, PMP22, MPZ, NEFL, MTMR2
4MP:00107686.5MFN2, PMP22, HSPB8, MPZ, MTMR2, KIF1B

Publications for Tooth Disease

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Articles related to Tooth Disease:

(show top 50)    (show all 851)
idTitleAuthorsYear
1
Tremor in Charcot-Marie-Tooth disease: No evidence of cerebellar dysfunction. (25641441)
2015
2
Exome sequencing reveals mutations in MFN2 and GDAP1 in severe Charcot-Marie-Tooth disease. (25403865)
2014
3
Charcot-Marie-Tooth disease type 2A: from typical to rare phenotypic and genotypic features. (24957169)
2014
4
Pain and small fiber function in Charcot Marie Tooth disease type 1A. (24395492)
2014
5
Charcot-marie-tooth disease and other inherited neuropathies. (25299278)
2014
6
Animal models and therapeutic prospects for Charcot-Marie-Tooth disease. (23913540)
2013
7
New mutation in periaxin gene causing Charcot Marie Tooth disease in a Puerto Rican young male. (24263033)
2013
8
Rapid genetic screening of Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies patients. (25337104)
2012
9
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. (22371199)
2012
10
A novel MPZ mutation in Charcot-Marie-Tooth disease type 1B with focally folded myelin and multiple entrapment neuropathies. (21940171)
2012
11
Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation. (22271166)
2012
12
A pilot study of a crossover trial with randomized use of ankle-foot orthoses for people with Charcot-Marie-tooth disease. (22089961)
2012
13
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
14
Inheritance of Charcot-Marie-Tooth disease 1A with rare nonrecurrent genomic rearrangement. (21193943)
2011
15
Intractable epilepsy, audio-visual hallucinations and Charcot-Marie-Tooth disease 1A in an African-American boy. (21870475)
2011
16
Charcot-Marie-Tooth disease complicating type 2 diabetes. (21817005)
2011
17
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease. (21820100)
2011
18
Copy number variations are a rare cause of non-CMT1A Charcot-Marie-Tooth disease. (19949810)
2010
19
Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. (19950375)
2010
20
Novel FH mutation in a patient with cutaneous leiomyomatosis associated with cutis verticis gyrata, eruptive collagenoma and Charcot-Marie-Tooth disease. (20560959)
2010
21
Charcot-Marie-Tooth disease. (19277060)
2009
22
Molecular diagnosis of axonal forms of Charcot-Marie-Tooth disease]. (19942244)
2009
23
Poor compliance with ankle-foot-orthoses in Charcot-Marie-Tooth disease. (18385625)
2008
24
Charcot-Marie-Tooth disease and the cavovarus foot. (18457773)
2008
25
Phosphoinositides and Charcot-Marie-tooth disease: new keys to old questions. (17965826)
2007
26
Anesthetic management of a parturient with neurofibromatosis 1 and Charcot-Marie-Tooth disease. (17869996)
2007
27
Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance. (17294201)
2007
28
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. (16452125)
2006
29
Gene symbol: MPZ. Disease: Charcot-Marie-Tooth disease. Accession #Hm0551. (17297707)
2006
30
Prevalence of Charcot-Marie-Tooth disease in patients who have bilateral cavovarus feet. (16791058)
2006
31
A novel out-of-frame mutation in the neurofilament light chain gene (NEFL) does not result in Charcot-Marie-Tooth disease type 2E. (15654615)
2005
32
Autosomal-recessive Charcot-Marie-Tooth diseases. (15892292)
2005
33
An animal model for Charcot-Marie-Tooth disease type 4B1. (16249189)
2005
34
Charcot-Marie-Tooth disease type 1A with central nervous system involvement in two generations. (15083299)
2004
35
Charcot-Marie-Tooth disease type 1A: a clinical, electrophysiological, pathological, and genetic study. (15239197)
2004
36
Central neural blockade in Charcot-Marie-Tooth disease. (15574563)
2004
37
Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A? (15363066)
2004
38
Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. (14561495)
2003
39
Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. (12477167)
2002
40
A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3. (11112660)
2001
41
The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (10369162)
1999
42
Charcot-Marie-Tooth disease with intermediate motor nerve conduction velocities: characterization of 14 Cx32 mutations in 35 families. (9401007)
1997
43
Novel mutation of the myelin Po gene in a pedigree with Charcot- Marie-Tooth disease type 1B. (9217235)
1997
44
Normalized Southern Hybridization to Enhance Testing for Charcot-Marie-Tooth Disease, Type 1A. (10330199)
1996
45
Mosaicism for the Charcot-Marie-Tooth disease type 1A duplication suggests somatic reversion. (8682501)
1996
46
Arginine-164-tryptophan substitution in connexin32 associated with X linked dominant Charcot-Marie-Tooth disease. (8733054)
1996
47
Phenotypic heterogeneity in Japanese Charcot-Marie-Tooth disease type 1A patients with PMP-22 gene duplication]. (8821490)
1995
48
Mutations in the connexin 32 gene in X-linked dominant Charcot-Marie- Tooth disease (CMTX1). (8162049)
1994
49
Linkage and mutation analysis in an extended family with Charcot- Marie-Tooth disease type 1B. (7530774)
1994
50
Progressive muscular atrophy of the peroneal type (Charcot-Marie-Tooth disease) orthopaedic management and end-result study. (15401720)
1950

Variations for Tooth Disease

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Expression for genes affiliated with Tooth Disease

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Search GEO for disease gene expression data for Tooth Disease.

Pathways for genes affiliated with Tooth Disease

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Pathways related to Tooth Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3GJB1, MPZ, PMP22

Compounds for genes affiliated with Tooth Disease

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Compounds related to Tooth Disease according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1dihydroprogesterone4310.0MPZ, PMP22
2ganglioside439.5MPZ, PMP22
3dbc-amp439.5EGR2, HSPB1
4forskolin43 49 1210.9PMP22, HSPB1, GJB1
5progesterone43 28 59 24 1212.9GJB1, MPZ, HSPB1, PMP22
6arginine438.9PMP22, HSPB1, MPZ, GJB1
7cysteine438.7GJB1, MPZ, HSPB1, PMP22
8retinoic acid43 249.7PMP22, HSPB1, NEFL, GJB1
9tyrosine438.3EGR2, GJB1, MTMR2, MPZ, HSPB1

GO Terms for genes affiliated with Tooth Disease

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Biological processes related to Tooth Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin assemblyGO:00322889.7MTMR2, PMP22
2peripheral nervous system developmentGO:00074229.7PMP22, EGR2
3anterograde axon cargo transportGO:00080899.6KIF1B, NEFL
4synaptic transmissionGO:00072689.5NEFL, MPZ, PMP22
5protein targeting to mitochondrionGO:00066269.5MFN2, GDAP1
6cell deathGO:00082198.7HSPB1, HSPB8, MFN2

Molecular functions related to Tooth Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.6EGR2, KIF1B, MTMR2, NEFL, HSPB1, HSPB8

Products for genes affiliated with Tooth Disease

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Sources for Tooth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet