MCID: TTH006
MIFTS: 56

Tooth Disease malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Tooth Disease

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MedlinePlus:33 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards based summary: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease and hereditary neuropathy with liability to pressure palsies. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The drugs camphor and camphor oil and the compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are normal and behavior/neurological.

Wikipedia:65 Tooth pathology (or tooth diseases, tooth disorders or dental pathology), is any condition of the teeth... more...

Aliases & Classifications for Tooth Disease

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Tooth Disease, Aliases & Descriptions:

Name: Tooth Disease 8
Dental Disorder 8 44
Tooth Disorders 33 62
 
Dental Diseases 62
Tooth Diseases 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:1091
NCIt39 C35077
MeSH34 D014076
ICD1025 K02.9

Related Diseases for Tooth Disease

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Diseases related to Tooth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease32.5MPZ, PMP22
2hereditary neuropathy with liability to pressure palsies31.3PMP22
3charcot-marie-tooth disease type 431.1EGR2, MPZ, PMP22
4chronic inflammatory demyelinating polyneuropathy30.8MPZ, PMP22
5hereditary neuropathies30.6GJB1, MTMR2, MPZ, PMP22
6pelizaeus-merzbacher disease30.4MPZ
7polyneuropathy30.4PMP22, MPZ, GJB1, EGR2
8neuritis30.1PMP22, MPZ
9charcot-marie-tooth disease type 330.1EGR2, GJB1, MPZ, PMP22
10axonal neuropathy30.0KIF1B, HSPB1
11multiple sclerosis30.0HSPB1, MPZ, NEFL
12charcot-marie-tooth neuropathy type 129.8PMP22, MPZ, NEFL, EGR2
13inherited peripheral neuropathy29.8PMP22, MPZ, GJB1, EGR2
14neuropathy29.6GDAP1, MFN2, PMP22, HSPB8, MPZ, NEFL
15charcot-marie-tooth neuropathy type 228.6GDAP1, MFN2, HSPB8, HSPB1, MPZ, NEFL
16myopathy27.8EGR2, GJB1, MTMR2, GDAP1, MFN2, PMP22
17charcot-marie-tooth disease type 1a11.0
18charcot-marie-tooth disease type 110.7
19charcot-marie-tooth disease type 210.7
20charcot-marie-tooth disease type 1b10.6
21charcot-marie-tooth disease type 2b10.5
22charcot-marie-tooth disease type 2a10.5
23charcot-marie-tooth disease type 2b210.5
24charcot-marie-tooth disease type 2c10.5
25charcot-marie-tooth disease type 2d10.5
26charcot-marie-tooth disease type 1d10.5
27charcot-marie-tooth disease type 2b110.5
28charcot-marie-tooth disease type 2f10.5
29charcot-marie-tooth disease type 4b110.5
30charcot-marie-tooth disease type 1c10.4
31charcot-marie-tooth disease type 2g10.4
32charcot-marie-tooth neuropathy type 4a10.4
33charcot-marie-tooth disease type 2h10.4
34charcot-marie-tooth disease type 2j10.4
35charcot-marie-tooth disease type 2k10.4
36hereditary neuropathy with liability to pressure palsy10.4
37autosomal dominant intermediate charcot-marie-tooth disease type e10.4
38charcot-marie-tooth disease x-linked 110.4
39charcot-marie-tooth disease type 1f10.4
40charcot-marie-tooth disease type 2i10.4
41charcot-marie-tooth disease type 4b210.4
42polyradiculoneuropathy10.4PMP22
43charcot-marie-tooth neuropathy type 4c10.3
44x-linked charcot-marie-tooth disease type 510.3
45charcot-marie-tooth neuropathy type 1a10.3PMP22, MPZ
46charcot-marie-tooth disease type x10.3
47charcot-marie-tooth disease x-linked recessive 210.3
48charcot-marie-tooth disease x-linked recessive 310.3
49brachial plexus neuropathy10.3PMP22, MPZ
50peripheral neuropathy10.3

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Symptoms for Tooth Disease

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Drugs & Therapeutics for Tooth Disease

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Drug clinical trials:

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Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS62/NDF-RT40:

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Genetic Tests for Tooth Disease

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Anatomical Context for Tooth Disease

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MalaCards organs/tissues related to Tooth Disease:

32
Testes, Bone, Brain, Spinal cord, Skeletal muscle

Animal Models for Tooth Disease or affiliated genes

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MGI Mouse Phenotypes related to Tooth Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2EGR2, MTMR2, NEFL, HSPB1, MFN2
2MP:00053867.5MFN2, PMP22, MPZ, MTMR2, KIF1B, GJB1
3MP:00036317.2EGR2, MFN2, PMP22, MPZ, NEFL, MTMR2
4MP:00107686.5MFN2, PMP22, HSPB8, MPZ, MTMR2, KIF1B

Publications for Tooth Disease

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Articles related to Tooth Disease:

(show top 50)    (show all 822)
idTitleAuthorsYear
1
Exome sequencing reveals mutations in MFN2 and GDAP1 in severe Charcot-Marie-Tooth disease. (25403865)
2014
2
Charcot-Marie-Tooth disease type 2A: from typical to rare phenotypic and genotypic features. (24957169)
2014
3
Pain and small fiber function in Charcot Marie Tooth disease type 1A. (24395492)
2014
4
Charcot-marie-tooth disease and other inherited neuropathies. (25299278)
2014
5
Animal models and therapeutic prospects for Charcot-Marie-Tooth disease. (23913540)
2013
6
New mutation in periaxin gene causing Charcot Marie Tooth disease in a Puerto Rican young male. (24263033)
2013
7
Rapid genetic screening of Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies patients. (25337104)
2012
8
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. (22371199)
2012
9
A novel MPZ mutation in Charcot-Marie-Tooth disease type 1B with focally folded myelin and multiple entrapment neuropathies. (21940171)
2012
10
Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation. (22271166)
2012
11
A pilot study of a crossover trial with randomized use of ankle-foot orthoses for people with Charcot-Marie-tooth disease. (22089961)
2012
12
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
13
Inheritance of Charcot-Marie-Tooth disease 1A with rare nonrecurrent genomic rearrangement. (21193943)
2011
14
Intractable epilepsy, audio-visual hallucinations and Charcot-Marie-Tooth disease 1A in an African-American boy. (21870475)
2011
15
Charcot-Marie-Tooth disease complicating type 2 diabetes. (21817005)
2011
16
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease. (21820100)
2011
17
Copy number variations are a rare cause of non-CMT1A Charcot-Marie-Tooth disease. (19949810)
2010
18
Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. (19950375)
2010
19
Novel FH mutation in a patient with cutaneous leiomyomatosis associated with cutis verticis gyrata, eruptive collagenoma and Charcot-Marie-Tooth disease. (20560959)
2010
20
Charcot-Marie-Tooth disease. (19277060)
2009
21
Molecular diagnosis of axonal forms of Charcot-Marie-Tooth disease]. (19942244)
2009
22
Poor compliance with ankle-foot-orthoses in Charcot-Marie-Tooth disease. (18385625)
2008
23
Charcot-Marie-Tooth disease and the cavovarus foot. (18457773)
2008
24
Phosphoinositides and Charcot-Marie-tooth disease: new keys to old questions. (17965826)
2007
25
Anesthetic management of a parturient with neurofibromatosis 1 and Charcot-Marie-Tooth disease. (17869996)
2007
26
Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance. (17294201)
2007
27
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. (16452125)
2006
28
Gene symbol: MPZ. Disease: Charcot-Marie-Tooth disease. Accession #Hm0551. (17297707)
2006
29
Prevalence of Charcot-Marie-Tooth disease in patients who have bilateral cavovarus feet. (16791058)
2006
30
A novel out-of-frame mutation in the neurofilament light chain gene (NEFL) does not result in Charcot-Marie-Tooth disease type 2E. (15654615)
2005
31
Autosomal-recessive Charcot-Marie-Tooth diseases. (15892292)
2005
32
An animal model for Charcot-Marie-Tooth disease type 4B1. (16249189)
2005
33
Charcot-Marie-Tooth disease type 1A with central nervous system involvement in two generations. (15083299)
2004
34
Charcot-Marie-Tooth disease type 1A: a clinical, electrophysiological, pathological, and genetic study. (15239197)
2004
35
Central neural blockade in Charcot-Marie-Tooth disease. (15574563)
2004
36
Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A? (15363066)
2004
37
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. (15122254)
2004
38
Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. (14561495)
2003
39
Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. (12477167)
2002
40
A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3. (11112660)
2001
41
The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (10369162)
1999
42
Charcot-Marie-Tooth disease with intermediate motor nerve conduction velocities: characterization of 14 Cx32 mutations in 35 families. (9401007)
1997
43
Novel mutation of the myelin Po gene in a pedigree with Charcot- Marie-Tooth disease type 1B. (9217235)
1997
44
Normalized Southern Hybridization to Enhance Testing for Charcot-Marie-Tooth Disease, Type 1A. (10330199)
1996
45
Mosaicism for the Charcot-Marie-Tooth disease type 1A duplication suggests somatic reversion. (8682501)
1996
46
Arginine-164-tryptophan substitution in connexin32 associated with X linked dominant Charcot-Marie-Tooth disease. (8733054)
1996
47
Phenotypic heterogeneity in Japanese Charcot-Marie-Tooth disease type 1A patients with PMP-22 gene duplication]. (8821490)
1995
48
Mutations in the connexin 32 gene in X-linked dominant Charcot-Marie- Tooth disease (CMTX1). (8162049)
1994
49
Linkage and mutation analysis in an extended family with Charcot- Marie-Tooth disease type 1B. (7530774)
1994
50
Progressive muscular atrophy of the peroneal type (Charcot-Marie-Tooth disease) orthopaedic management and end-result study. (15401720)
1950

Variations for Tooth Disease

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Expression for genes affiliated with Tooth Disease

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Expression patterns in normal tissues for genes affiliated with Tooth Disease

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Pathways for genes affiliated with Tooth Disease

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Pathways related to Tooth Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3GJB1, MPZ, PMP22

Compounds for genes affiliated with Tooth Disease

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Compounds related to Tooth Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dihydroprogesterone4410.0MPZ, PMP22
2ganglioside449.5MPZ, PMP22
3dbc-amp449.5EGR2, HSPB1
4forskolin44 50 1110.9PMP22, HSPB1, GJB1
5progesterone44 28 61 24 1112.9GJB1, MPZ, HSPB1, PMP22
6arginine448.9PMP22, HSPB1, MPZ, GJB1
7cysteine448.7GJB1, MPZ, HSPB1, PMP22
8retinoic acid44 249.7PMP22, HSPB1, NEFL, GJB1
9tyrosine448.3EGR2, GJB1, MTMR2, MPZ, HSPB1

GO Terms for genes affiliated with Tooth Disease

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Biological processes related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin assemblyGO:0322889.7MTMR2, PMP22
2peripheral nervous system developmentGO:0074229.7PMP22, EGR2
3anterograde axon cargo transportGO:0080899.6KIF1B, NEFL
4synaptic transmissionGO:0072689.5NEFL, MPZ, PMP22
5protein targeting to mitochondrionGO:0066269.5MFN2, GDAP1
6cell deathGO:0082198.7HSPB1, HSPB8, MFN2

Molecular functions related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6EGR2, KIF1B, MTMR2, NEFL, HSPB1, HSPB8

Products for genes affiliated with Tooth Disease

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Sources for Tooth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet