MCID: TTH006
MIFTS: 51

Tooth Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Tooth Disease

MalaCards integrated aliases for Tooth Disease:

Name: Tooth Disease 12 14
Dental Disorder 12 52
Tooth Diseases 42 69
Tooth Disorders 41
Dental Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1091
MeSH 42 D014076
ICD10 33 K02.9
UMLS 69 C0040435

Summaries for Tooth Disease

MedlinePlus : 41 your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards based summary : Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease, type 2j and charcot-marie-tooth disease, type 2i, and has symptoms including halitosis, snoring and toothache. An important gene associated with Tooth Disease is GJB1 (Gap Junction Protein Beta 1), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Acetylcholine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and kidney, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Tooth Disease

Diseases related to Tooth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
id Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease, type 2j 34.5 KIF1B MPZ
2 charcot-marie-tooth disease, type 2i 34.3 KIF1B MPZ
3 charcot-marie-tooth disease, type 2a1 34.3 KIF1B MFN2
4 charcot-marie-tooth disease, type 1b 34.1 EGR2 GJB1 KIF1B MPZ PMP22
5 charcot-marie-tooth disease type 2g 34.1 KIF1B MFN2
6 charcot-marie-tooth disease, recessive intermediate, a 34.1 GDAP1 KIF1B MFN2
7 charcot-marie-tooth disease type 2n 34.1 GDAP1 LRSAM1
8 charcot-marie-tooth disease, type 2b1 34.0 GDAP1 LMNA
9 charcot-marie-tooth disease, type 1e 33.5 EGR2 GDAP1 GJB1 KIF1B LITAF MFN2
10 charcot-marie-tooth disease, axonal, with vocal cord paresis 33.3 GDAP1 MTMR2
11 dejerine-sottas disease 32.4 EGR2 GDAP1 GJB1 KIF1B LITAF MPZ
12 charcot-marie-tooth disease, type 1f 32.3 EGR2 GARS GDAP1 GJB1 KIF1B LMNA
13 charcot-marie-tooth neuropathy type 4j 32.2 EGR2 GJB1 MPZ PMP22
14 charcot-marie-tooth neuropathy x type 1 32.1 KIF1B MFN2
15 charcot-marie-tooth neuropathy x 31.8 GARS GDAP1 GJB1 MPZ PMP22
16 neuropathy, congenital hypomyelinating 31.0 EGR2 FGD4 FIG4 GDAP1 GJB1 KIF1B
17 charcot-marie-tooth disease 12.3
18 charcot-marie-tooth disease, type 2e 12.3
19 charcot-marie-tooth disease, type 1a 12.3
20 charcot-marie-tooth disease, type 4h 12.2
21 charcot-marie-tooth disease, type 4b2 12.2
22 charcot-marie-tooth disease, type 4a 12.2
23 charcot-marie-tooth disease, type 4c 12.2
24 charcot-marie-tooth disease, type 4b1 12.2
25 charcot-marie-tooth disease, type 2b 12.2
26 charcot-marie-tooth disease, type 2d 12.2
27 charcot-marie-tooth disease, type 4j 12.2
28 charcot-marie-tooth disease, type 4d 12.2
29 charcot-marie-tooth disease, type 1c 12.2
30 charcot-marie-tooth disease, type 1d 12.2
31 charcot-marie-tooth disease, type 4f 12.2
32 charcot-marie-tooth disease, type 4b3 12.2
33 charcot-marie-tooth disease, axonal, type 2k 12.1
34 charcot-marie-tooth disease, type 2b2 12.1
35 charcot-marie-tooth disease, dominant intermediate b 12.1
36 charcot-marie-tooth disease, type 4k 12.1
37 charcot-marie-tooth disease, axonal, type 2s 12.1
38 charcot-marie-tooth disease, axonal, type 2p 12.1
39 charcot-marie-tooth disease, dominant intermediate e 12.1
40 charcot-marie-tooth disease, axonal, type 2u 12.1
41 charcot-marie-tooth disease, axonal, type 2q 12.1
42 charcot-marie-tooth disease, type 2r 12.1
43 charcot-marie-tooth disease, axonal, type 2l 12.1
44 charcot-marie-tooth disease, axonal, type 2n 12.1
45 charcot-marie-tooth disease, axonal, type 2v 12.1
46 charcot-marie-tooth disease, axonal, type 2z 12.1
47 charcot-marie-tooth disease, axonal, type 2f 12.1
48 charcot-marie-tooth disease, axonal, type 2x 12.1
49 charcot-marie-tooth disease, x-linked recessive, 5 12.1
50 charcot-marie-tooth disease, axonal, type 20 12.1

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to Tooth Disease

Symptoms & Phenotypes for Tooth Disease

UMLS symptoms related to Tooth Disease:


halitosis, snoring, toothache, poor dentition, orofacial pain

MGI Mouse Phenotypes related to Tooth Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 EGR2 FGD4 FIG4 GARS GDAP1 GJB1
2 mortality/aging MP:0010768 10.1 EGR2 FIG4 GARS GJB1 KIF1B LMNA
3 cellular MP:0005384 10.07 EGR2 GDAP1 GJB1 HSPB1 LITAF LMNA
4 limbs/digits/tail MP:0005371 9.87 EGR2 FIG4 GDAP1 LMNA MED25 MTMR2
5 nervous system MP:0003631 9.86 MPZ MTMR2 NEFL PMP22 SH3TC2 EGR2
6 muscle MP:0005369 9.7 FIG4 GARS KIF1B LMNA MFN2 PMP22
7 normal MP:0002873 9.17 HSPB1 EGR2 GARS NEFL LMNA MFN2

Drugs & Therapeutics for Tooth Disease

Drugs for Tooth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 456)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
2
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
3
Ephedrine Approved Phase 4 299-42-3 9294
4
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
5
Oxymetazoline Approved Phase 4 1491-59-4 4636
6
Phenylephrine Approved Phase 4 59-42-7 6041
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
9
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
10 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7681-49-4
11
Hydrogen peroxide Approved, Vet_approved Phase 4,Phase 3,Phase 1 7722-84-1 784
12
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 55-56-1 9552079 2713
13
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
14
Sorbitol Approved Phase 4,Phase 2,Phase 3 50-70-4 5780
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 22916-47-8 4189
16
Salicylic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 69-72-7 338
17
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
18
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
19
Methamphetamine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1 537-46-2 10836
20
Alginic acid Approved, Experimental Phase 4,Phase 1,Phase 2 9005-32-7
21
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
22
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
23
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
24
Codeine Approved, Illicit Phase 4,Phase 3,Phase 2 76-57-3 5284371
25
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
26
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2 93-14-1 3516
27
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
28 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29
Esomeprazole Approved, Investigational Phase 4,Phase 1,Phase 2 161796-78-7, 119141-88-7 4594 9579578
30
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22204-53-1 1302 156391
31
Piroxicam Approved, Investigational Phase 4,Phase 3 36322-90-4 5280452 54676228
32
Amoxicillin Approved, Vet_approved Phase 4,Early Phase 1 26787-78-0 33613 2171
33
Glycerol Approved, Investigational Phase 4 56-81-5 753
34
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
35
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
36
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
37
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
38
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
39
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 27203-92-5 33741
40
Cimetidine Approved Phase 4 51481-61-9 2756
41 Cetylpyridinium Approved Phase 4,Phase 3,Phase 2,Phase 1 7773-52-6
42
Triclosan Approved Phase 4,Phase 3,Phase 2 3380-34-5 5564
43
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Early Phase 1 103-90-2 1983
44
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
45
Hydrocodone Approved, Illicit Phase 4,Phase 2 125-29-1 5284569
46
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 76-42-6 5284603
47
Capsaicin Approved Phase 4 404-86-4 1548943
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
49
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
50
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032

Interventional clinical trials:

(show top 50) (show all 1343)

id Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
3 Dental Caries Management by Risk Assessment: Identification and Treatment of Risk Factors Among (IDF) Personnel Unknown status NCT01142440 Phase 4
4 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
5 Elmex Gel Efficacy in Preventing White Spot Lesions Unknown status NCT00268138 Phase 4 elmex gel
6 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
7 Evaluation of a Lateral Window Technique Augmentation for Maxillary Sinus Using Ultrasound Activated Pins Unknown status NCT02449707 Phase 4
8 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
9 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
10 Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel Unknown status NCT00846690 Phase 4 benzocaine;TAC alternate gel
11 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
12 Ketamine on Acute Pain in Females and Males Completed NCT00232492 Phase 4 Placebo males;Ketamine 0,1 mg/kg males;Ketamine 0,3 mg/kg males;Ketamine 0,5 mg/kg males;Placebo females;Ketamine 0,1 mg/kg females;Ketamine 0,3 mg/kg females;Ketamine 0,5 mg/kg females
13 The Effect of Whitening Toothpaste on Tooth Color Associated With Bleaching Process Completed NCT03163069 Phase 4
14 Efficacy of a Whitening Dentifrice on Tooth Discoloration Completed NCT02741427 Phase 4
15 Clinical Effectiveness of In-office Bleaching Activated With a LED/Laser Device Completed NCT01231243 Phase 4
16 Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners Completed NCT01962012 Phase 4
17 An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining Completed NCT01962493 Phase 4 Chlorhexidine digluconate
18 Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction. Completed NCT02547896 Phase 4 Codeine + Diclofenac;Diclofenac
19 Lower Third Molar Removal With 2% and 4% Articaine Completed NCT02457325 Phase 4 Surgery with 2% articaine;Surgery with 4% articaine
20 Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal Completed NCT02494856 Phase 4 Surgery with Naproxen;Surgery with Naproxen and Esomeprazole
21 Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery Completed NCT02450487 Phase 4 Piroxicam
22 Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients Completed NCT02017873 Phase 4 Peroxide Carbamide 10% - Dental bleaching treatment
23 AUGMENTIN™ in Dental Infections Completed NCT02141217 Phase 4 Amoxicillin/clavulanate;Clindamycin
24 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Completed NCT00638677 Phase 4
25 Clinical Study of the Whitening Dentifrices on Tooth Color and Sensitivity Completed NCT02483013 Phase 4
26 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 Articaine local anesthetic;Lidocaine local anesthetic
27 Impact of Fluoride Vanish Application in Dental Prevention for Elderly Completed NCT01038817 Phase 4 Duraphat
28 An Evaluation of the Efficacy of Oral-B New Product Sensi-Stop on Dentinal Hypersensitivity Completed NCT02476032 Phase 4
29 Use of Fissure Sealants on Primary Molars Completed NCT01438866 Phase 4
30 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
31 Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients Completed NCT01329731 Phase 4 elmex® gelée;negative control (placebo)
32 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
33 Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity Completed NCT02895321 Phase 4
34 Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity Completed NCT02773758 Phase 4
35 Comparison of the Effect of Fluoride Remineralizer Gel and Foam Completed NCT02490592 Phase 4
36 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study Completed NCT02424097 Phase 4 CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste;1,100pm F-toothpaste and 0.5%NaF rinse
37 Caries-preventive Effect of a Dentifrice Containing 5,000 Ppm Fluoride in Orthodontic Patients Completed NCT01768390 Phase 4
38 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
39 Preventive and Therapeutic Proximal Sealants Completed NCT02338180 Phase 4
40 Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study Completed NCT00723515 Phase 4 sodium fluoride;sodium fluoride calcium fluoride
41 Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Completed NCT02592278 Phase 4 Fluoride Varnish;Control Group
42 Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02731833 Phase 4
43 To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) Completed NCT02923895 Phase 4
44 Fuji Type VII Sealant Versus Resin Based Sealant. A Clinical Trial Completed NCT02795728 Phase 4
45 Effectiveness of Fluoride Varnish in the Prevention of Early Childhood Caries: A Randomized Controlled Trial Completed NCT02742038 Phase 4
46 Impact of Maternal Xylitol Consumption on Mutans Sterptococci Completed NCT02036151 Phase 4 xylitol;fluoride varnish application
47 Postoperative Pulpal Complications in Posterior Resin Composite Restorations Without Glass-ionomer Cement Lining Completed NCT01567514 Phase 4
48 Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride Completed NCT01563172 Phase 4 Sodium fluoride / silica and carbopol, 0.5g;Sodium fluoride / silica and carbopol, 1.5g;Sodium fluoride / silica and carbopol, 1.5g
49 Enamel Remineralization Potential of Dentifrices in Situ Completed NCT01128946 Phase 4 NaF;SnF;NaMFP
50 Efficacy of Moderate Sedation for Dental Treatment of Young Children Completed NCT00902395 Phase 4 Midazolam;Midazolam, ketamine

Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: tooth diseases

Genetic Tests for Tooth Disease

Anatomical Context for Tooth Disease

MalaCards organs/tissues related to Tooth Disease:

39
Bone, Testes, Kidney, Brain, Lung, Heart, Salivary Gland

Publications for Tooth Disease

Articles related to Tooth Disease:

(show top 50) (show all 999)
id Title Authors Year
1
Charcot-Marie-Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot-Marie-Tooth Examination Score. ( 28914656 )
2017
2
Mitochondrial trifunctional protein deficiency: an adult patient with similar progress to Charcot-Marie-Tooth disease. ( 28132977 )
2017
3
New mutation in a patient with Charcot-Marie-Tooth disease. ( 28318735 )
2017
4
Targeted exomes reveal simultaneous MFN2 and GDAP1 mutations in a severe Charcot-Marie-Tooth disease type 2 phenotype. ( 28211244 )
2017
5
Nine-hole Peg Test and Ten-meter Walk Test for Evaluating Functional Loss in Chinese Charcot-Marie-Tooth Disease. ( 28748848 )
2017
6
Clinical and mutational spectrum of Charcot-Marie-Tooth disease type 2Z caused by MORC2 variants in Japan. ( 28771897 )
2017
7
Identification and functional characterization of two missense mutations in NDRG1 associated with Charcot-Marie-Tooth disease type 4D. ( 28776325 )
2017
8
Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model. ( 28469666 )
2017
9
Natural history of Charcot-Marie-Tooth disease during childhood. ( 28796392 )
2017
10
Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study. ( 28660751 )
2017
11
Analysis of neural crest cells from Charcot-Marie-Tooth disease patients demonstrates disease-relevant molecular signature. ( 28704293 )
2017
12
Whole-Exome Sequencing Identifies a Novel Homozygous Frameshift Mutation in the MTMR2 Gene as a Causative Mutation in a Patient with Charcot-Marie-Tooth Disease Type 4B1. ( 28509084 )
2017
13
Confirmation of the GNB4 gene as causal for Charcot-Marie-Tooth disease by a novel de novo mutation in a Czech patient. ( 27908631 )
2017
14
Deterioration in gait and functional ambulation in children and adolescents with Charcot-Marie-Tooth disease over 12 months. ( 28495045 )
2017
15
Severe vincristine-induced polyneuropathy in a teenager with anaplastic medulloblastoma and undiagnosed Charcot-Marie-Tooth disease. ( 28438772 )
2017
16
Centrally involved X-linked Charcot-Marie-Tooth disease presenting as a stroke-mimic. ( 28097225 )
2017
17
Intermediate Charcot-Marie-Tooth disease: an electrophysiological reappraisal and systematic review. ( 28364294 )
2017
18
Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease. ( 28501821 )
2017
19
Effects of Self-Selected Exercise on Strength in Charcot-Marie-Tooth Disease Subtypes. ( 28669366 )
2017
20
Phenotypical features of a new dominant GDAP1 pathogenic variant (p.R226del) in axonal Charcot-Marie-Tooth disease. ( 28236508 )
2017
21
Generation of induced pluripotent stem cell (iPSC) line from a 36-year-old Charcot-Marie-Tooth disease patient with GJB1 mutation (CMTX). ( 28677541 )
2017
22
A Novel Missense Mutation in Peripheral Myelin Protein-22 Causes Charcot-Marie-Tooth Disease. ( 28748849 )
2017
23
Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease. ( 28297702 )
2017
24
Rapid Identification of Pathogenic Variants in Two Cases of Charcot-Marie-Tooth Disease by Gene-Panel Sequencing. ( 28379183 )
2017
25
Traduction franAsaise de l'Acchelle Charcot-Marie-Tooth Disease Pediatric Scale. ( 28814348 )
2017
26
Charcot-Marie-Tooth disease type 2 caused by homozygous MME gene mutation superimposed by chronic inflammatory demyelinating polyneuropathy. ( 28855494 )
2017
27
Rigid spine syndrome associated with sensory-motor axonal neuropathy resembling Charcot-Marie-Tooth disease is characteristic of Bcl-2-associated athanogene-3 gene mutations even without cardiac involvement. ( 28224639 )
2017
28
Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study. ( 28810241 )
2017
29
Mutations in BAG3 cause adult-onset Charcot-Marie-Tooth disease. ( 28754666 )
2017
30
Erratum: Plasma neurofilament heavy chain is not a useful biomarker in Charcot-Marie-Tooth disease. ( 27995668 )
2017
31
Similar clinical, pathological, and genetic features in Chinese patients with autosomal recessive and dominant Charcot-Marie-Tooth disease type 2K. ( 28495047 )
2017
32
Cross-sectional analysis of a large cohort with X-linked Charcot-Marie-Tooth disease (CMTX1). ( 28768847 )
2017
33
A longitudinal clinicopathological study of two unrelated patients with Charcot-Marie-Tooth disease type 1E. ( 28681776 )
2017
34
LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P. ( 28335037 )
2017
35
Clinical and mutational spectrum of Japanese patients with Charcot-Marie-Tooth disease caused by GDAP1 variants. ( 28244113 )
2017
36
Biomarkers predict outcome in Charcot- Marie-Tooth disease 1A. ( 28860329 )
2017
37
Preimplantation genetic diagnosis of X-linked Charcot-Marie-Tooth disease by indirect linkage analysis. ( 28797703 )
2017
38
Unilateral oculomotor palsy in Charcot-Marie-Tooth disease 1A (CMT 1A). ( 28214652 )
2017
39
Clinical characterization and genetic analysis of Korean patients with X-linked Charcot-Marie-Tooth disease type 1. ( 28448691 )
2017
40
Brain involvement in Charcot-Marie-Tooth disease due to ganglioside-induced differentiation associated-protein 1 mutation. ( 28673555 )
2017
41
Gait patterns of children and adolescents with Charcot-Marie-Tooth disease. ( 28527386 )
2017
42
Motor neuron disease of very long disease duration or Charcot-Marie-Tooth disease? A novel phenotype related to the SOD1 p.E22G variant. ( 28579206 )
2017
43
Charcot-Marie-Tooth disease: genetic subtypes in the Sardinian population. ( 28286897 )
2017
44
A novel mutation in FGD4 causes Charcot-Marie-Tooth disease type 4H with cranial nerve involvement. ( 28847448 )
2017
45
Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease. ( 27957719 )
2016
46
Sport activity in Charcot-Marie-Tooth disease: A case study of a Paralympic swimmer. ( 27460291 )
2016
47
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-I+6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C. ( 27068304 )
2016
48
Screening for SH3TC2 gene mutations in a series of demyelinating recessive Charcot-Marie-Tooth disease (CMT4). ( 27231023 )
2016
49
Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation. ( 27328317 )
2016
50
Rehabilitation issues in Charcot-Marie-Tooth disease. ( 26966798 )
2016

Variations for Tooth Disease

Expression for Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for Tooth Disease

Pathways related to Tooth Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.81 GJB1 MPZ PMP22

GO Terms for Tooth Disease

Cellular components related to Tooth Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 FGD4 GARS GDAP1 HSPB1 LITAF LMNA
2 early endosome membrane GO:0031901 9.16 FIG4 MTMR2
3 axon cytoplasm GO:1904115 8.8 HSPB1 KIF1B NEFL

Biological processes related to Tooth Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.43 EGR2 PMP22
2 phosphatidylinositol biosynthetic process GO:0006661 9.43 FIG4 MTMR2 SBF1
3 phosphatidylinositol metabolic process GO:0046488 9.4 FIG4 MTMR2
4 mitochondrial fusion GO:0008053 9.37 GDAP1 MFN2
5 negative regulation of endocytosis GO:0045806 9.32 LRSAM1 MTMR2
6 negative regulation of myelination GO:0031642 9.16 FIG4 MTMR2
7 myelin assembly GO:0032288 8.96 FIG4 MTMR2
8 myelination GO:0042552 8.8 EGR2 MPZ PMP22

Molecular functions related to Tooth Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3-phosphatase activity GO:0004438 8.62 FIG4 MTMR2

Sources for Tooth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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