MCID: TTH006
MIFTS: 54

Tooth Disease malady

Gastrointestinal category

Summaries for Tooth Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease type 4b1 and charcot-marie-tooth disease type 4e. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways are Neural Crest Differentiation and Synthesis of PIPs at the early endosome membrane. The drugs camphor and camphor oil and the compounds arginine and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are mortality/aging and nervous system.

Wikipedia:64 A tooth disease is a disorder of the tooth that can be congenital or acquired. more...

Aliases & Classifications for Tooth Disease

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

tooth disease 8
dental disorder 8 45
tooth disorders 34
dental diseases 61
tooth diseases 61


External Ids:

Disease Ontology8 DOID:1091
NCIt40 C35077
MeSH35 D014076
ICD1025 K02.9

Related Diseases for Tooth Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tooth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease type 4b130.6SBF2, MTMR2
2charcot-marie-tooth disease type 4e30.6EGR2, MPZ, PMP22
3hereditary neuropathies30.3LMNA, GJB1, MTMR2, MPZ, NDRG1, PMP22
4charcot-marie-tooth disease type 330.3PMP22, MPZ, EGR2, GJB1
5amyotrophic lateral sclerosis30.0HSPB1, NEFL
6charcot-marie-tooth neuropathy type 229.8KIF1B, LMNA, GDAP1, NEFL, MPZ, MFN2
7axonal neuropathy29.8KIF1B, HSPB1
8charcot-marie-tooth neuropathy type 129.8PMP22, EGR2, LITAF, NEFL, MPZ
9charcot-marie-tooth neuropathy type 1a29.8PMP22, MPZ
10pelizaeus-merzbacher disease29.8MPZ
11autosomal recessive disease10.6
12charcot-marie-tooth disease type 110.6
13charcot-marie-tooth hereditary neuropathy10.6
14autosomal dominant disease10.5
15charcot-marie-tooth disease type 2b210.5
16charcot-marie-tooth disease type 1a10.5
17charcot-marie-tooth disease type 1b10.5
18charcot-marie-tooth disease type 1e10.5
19charcot-marie-tooth disease type 2b10.5
20charcot-marie-tooth disease type 2b110.5
21charcot-marie-tooth disease type 2f10.5
22charcot-marie-tooth disease type 1d10.5
23charcot-marie-tooth disease type 2c10.5
24charcot-marie-tooth disease type 2g10.5
25charcot-marie-tooth neuropathy type 4a10.5
26charcot-marie-tooth disease type 2d10.5
27charcot-marie-tooth disease type 2h10.5
28charcot-marie-tooth disease type 2j10.5
29charcot-marie-tooth disease type 2k10.5
30autosomal dominant intermediate charcot-marie-tooth disease type e10.5
31charcot-marie-tooth disease type 1c10.5
32charcot-marie-tooth disease type 1f10.4
33charcot-marie-tooth disease type 2a10.4
34charcot-marie-tooth disease type 2e10.4
35charcot-marie-tooth disease type 2i10.4
36charcot-marie-tooth disease type 4b210.4
37charcot-marie-tooth disease x-linked 110.4
38charcot-marie-tooth disease type 410.4
39charcot-marie-tooth neuropathy type 4c10.4
40x-linked charcot-marie-tooth disease type 510.4
41char syndrome10.4
42charcot-marie-tooth disease x-linked recessive 210.4
43charcot-marie-tooth disease x-linked recessive 310.4
44charcot-marie-tooth disease type 210.3
45charcot-marie-tooth disease dominant intermediate 110.3
46charcot-marie-tooth disease dominant intermediate 210.3
47charcot-marie-tooth disease with pyramidal features, autosomal dominant10.3
48charcot-marie-tooth disease dominant intermediate 310.3
49charcot-marie-tooth disease, type 2a110.3
50charcot-marie-tooth disease, type 2a210.3

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Clinical Features for Tooth Disease

Drugs & Therapeutics for Tooth Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tooth Disease

Drug clinical trials:

Search ClinicalTrials for Tooth Disease

Search NIH Clinical Center for Tooth Disease

Search CenterWatch for Tooth Disease

Inferred drug relations via UMLS61/NDF-RT41:

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Genetic Tests for Tooth Disease

Anatomical Context for Tooth Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Tooth Disease:

33
Whole blood, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, T cells

Animal Models for Tooth Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tooth Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.5HSPB8, NDRG1, MFN2, EGR2, MPZ, MTMR2
2MP:000363110.5KIF1B, PMP22, NDRG1, MFN2, EGR2, MPZ
3MP:000538610.4PMP22, NDRG1, MFN2, EGR2, MPZ, MTMR2
4MP:000536910.2PMP22, HSPB8, NDRG1, MFN2, FIG4, LMNA

Publications for Tooth Disease

Sources:
51PubMed
See all sources

Articles related to Tooth Disease:

(show top 50)    (show all 864)
idTitleAuthorsYear
1
Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease. (23519028)
2013
2
A chronic leg ulcer presenting with Charcot-Marie-Tooth disease and type 2 diabetes: a case report. (23446367)
2013
3
Effects of muscular deficiency on postural and gait capacities in patients with Charcot-Marie-Tooth disease. (23412436)
2013
4
Genetics of the Charcot-Marie-Tooth disease in the Spanish Gypsy population: the hereditary motor and sensory neuropathy-Russe in depth. (22978647)
2013
5
A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene. (23297365)
2013
6
A compound heterozygous mutation in HADHB gene causes an axonal Charcot-Marie-tooth disease. (24314034)
2013
7
Measuring Ankle Instability in Pediatric Charcot-Marie-Tooth Disease. (23696628)
2013
8
Management of pathological tooth migration in patients with advanced periodontal disease. (24225140)
2013
9
X-linked Charcot-Marie-Tooth disease. (23279425)
2012
10
Dynamin 2 in Charcot-Marie-Tooth disease. (22729098)
2012
11
Charcot-Marie-Tooth disease in Northern England. (21984771)
2012
12
A novel mutation in the nerve-specific 5'UTR of the GJB1 gene causes X-linked Charcot-Marie-Tooth disease. (21504505)
2011
13
Molecular diagnosis and clinical onset of Charcot-Marie-Tooth disease in Japan. (21326314)
2011
14
Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. (21896645)
2011
15
Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: an aid for treatment planning. (20451772)
2010
16
A new mutation in the GJB1 gene of a Chinese family with Charcot-Marie-Tooth disease associated with vocal cord paresis]. (20931524)
2010
17
Novel human pathological mutations. Gene symbol: GDAP1. Disease: Charcot-Marie-Tooth disease 4A. (19320013)
2009
18
Mitochondrial and axonal abnormalities precede disruption of the neurofilament network in a model of charcot-marie-tooth disease type 2E and are prevented by heat shock proteins in a mutant-specific fashion. (19458545)
2009
19
Screening of the 17p11.2--p12 region in a large cohort of patients with Charcot-Marie-Tooth (CMT) disease or hereditary neuropathy with liability to pressure palsies (HNPP). (19638685)
2009
20
Poor compliance with ankle-foot-orthoses in Charcot-Marie-Tooth disease. (18385625)
2008
21
Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A. (18844790)
2008
22
A novel mutation in the GDAP1 gene is associated with autosomal recessive Charcot-Marie-Tooth disease in an Amish family. (18492089)
2008
23
Charcot-Marie-tooth disease. (19825739)
2008
24
Novel human pathological mutations. Gene symbol: GJB1. Disease: Charcot-Marie-Tooth disease 1. (18383613)
2007
25
Charcot-Marie-Tooth disease type 4C4 caused by a novel Pro153Leu substitution in the GDAP1 gene. (18421898)
2007
26
A novel Cx32 mutation causes X-linked Charcot-Marie-Tooth disease with brainstem involvement and brain magnetic resonance spectroscopy abnormalities. (16688595)
2006
27
Onset and duration of mivacurium-induced neuromuscular blockade in children with Charcot-Marie-Tooth disease. A case series with five children. (16430417)
2006
28
Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease with phenotypic variability. (16096811)
2006
29
A novel duplication/insertion mutation of NEFL in a patient with Charcot-Marie-Tooth disease. (16619203)
2006
30
The Bournemouth Questionnaire as an outcome measure in the rehabilitation of a person suffering with mechanical neck and arm pain and concurrent Charcot-Marie-Tooth disease: a case report. (17549156)
2006
31
A novel out-of-frame mutation in the neurofilament light chain gene (NEFL) does not result in Charcot-Marie-Tooth disease type 2E. (15654615)
2005
32
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. (15731758)
2005
33
Early onset Charcot-Marie-Tooth type 1B disease caused by a novel Leu190fs mutation in the myelin protein zero gene. (15261887)
2004
34
Charcot-Marie-Tooth disease: a novel Tyr145Ser mutation in the myelin protein zero (MPZ, P0) gene causes different phenotypes in homozygous and heterozygous carriers within one family. (12845552)
2003
35
Mutation analysis of neurofilament-light gene in Chinese Charcot-Marie-Tooth disease]. (12673592)
2003
36
Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A. (12802050)
2003
37
Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients. (12477701)
2003
38
Expression of peripheral myelin protein zero in sural nerve of patients with Charcot-Marie-Tooth disease 1B. (11182278)
2001
39
Disability and quality of life in Charcot-Marie-Tooth disease type 1. (11254787)
2001
40
Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases. (10982389)
2000
41
Connexin channels in Schwann cells and the development of the X-linked form of Charcot-Marie-Tooth disease. (10751670)
2000
42
Demyelinating X-linked Charcot-Marie-Tooth disease: unusual electrophysiological findings. (10487913)
1999
43
Mutations of connexin32 in Charcot-Marie-Tooth disease type X interfere with cell-to-cell communication but not cell proliferation and myelin-specific gene expression. (9469569)
1998
44
Pregnancy after preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A. (9809680)
1998
45
Novel mutation of the myelin Po gene in a pedigree with Charcot- Marie-Tooth disease type 1B. (9217235)
1997
46
Connexin32 and X-linked Charcot-Marie-Tooth disease. (9361298)
1997
47
A new mutation of the Po gene in patients with Charcot-Marie-Tooth disease type 1B: screening of the Po gene by heteroduplex analysis. (8938258)
1996
48
The gene for the peripheral myelin protein PMP-22 is a candidate for Charcot-Marie-Tooth disease type 1A. (1303228)
1992
49
X-linked Charcot-Marie-Tooth disease. A linkage study in a large family by using 12 probes of the pericentromeric region. (1674715)
1991
50
Quantitation of Meissner's corpuscles in hereditary neurologic disorders. Charcot-Marie-Tooth disease, Roussy-Levy syndrome, Dejerine-Sottas disease, hereditary sensory neuropathy, spinocerebellar degenerations, and hereditary spastic paraplegia. (5948001)
1966

Genetic Variations for Tooth Disease

Expression for genes affiliated with Tooth Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for genes affiliated with Tooth Disease

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Tooth Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5GJB1, MPZ
2
Hide members
10.5FIG4, MTMR2

Compounds for genes affiliated with Tooth Disease

Sources:
45Novoseek
See all sources

Compounds related to Tooth Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arginine4510.5LMNA, GJB1, MPZ, HSPB1, PMP22
2dihydroprogesterone4510.2MPZ, PMP22

GO Terms for genes affiliated with Tooth Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5NDRG1, MFN2, NEFL, MTMR2, PRPS1, FGD4
2vacuolar membraneGO:00577410.2SBF2, MTMR2

Biological processes related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anterograde axon cargo transportGO:00808910.5KIF1B, NEFL
2myelin assemblyGO:03228810.5FIG4, MTMR2, PMP22
3negative regulation of myelinationGO:03164210.4FIG4, MTMR2
4peripheral nervous system myelin maintenanceGO:03228710.2SH3TC2, NDRG1

Molecular functions related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5KIF1B, HSPB8, HSPB1, NDRG1, MFN2, MED25

Products for genes affiliated with Tooth Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tooth Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet