MCID: TTH006
MIFTS: 55

Tooth Disease malady

Gastrointestinal diseases category

Summaries for Tooth Disease

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease and neuropathy. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways are Neural Crest Differentiation and Synthesis of PIPs at the early endosome membrane. The drugs camphor and camphor oil and the compounds arginine and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are mortality/aging and nervous system.

Wikipedia:63 Tooth pathology (or tooth diseases, tooth disorders or dental pathology), is any condition of the teeth... more...

Aliases & Classifications for Tooth Disease

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

tooth disease 8
dental disorder 8 44
tooth disorders 33
dental diseases 60
tooth diseases 60


External Ids:

Disease Ontology8 DOID:1091
NCIt39 C35077
MeSH34 D014076
ICD1025 K02.9

Related Diseases for Tooth Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tooth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease31.9MPZ, PMP22
2neuropathy31.1LMNA, GJB1, SBF2, GDAP1, FIG4, LITAF
3charcot-marie-tooth disease type 4b130.6MTMR2, SBF2
4hereditary neuropathy with liability to pressure palsies30.6PMP22
5charcot-marie-tooth disease type 4e30.5MPZ, EGR2, PMP22
6peripheral neuropathy30.5NDRG1
7charcot-marie-tooth neuropathy type 130.3LITAF, NEFL, MPZ, EGR2, PMP22
8polyneuropathy30.3PMP22, NDRG1, EGR2, MPZ, GJB1
9charcot-marie-tooth disease type 330.1GJB1, MPZ, EGR2, PMP22
10charcot-marie-tooth neuropathy type 230.0MFN2, HSPB1, HSPB8, MPZ, NEFL, GDAP1
11myopathy30.0FIG4, SH3TC2, MTMR2, NEFL, MPZ, EGR2
12amyotrophic lateral sclerosis30.0NEFL, HSPB1
13hereditary neuropathies29.8LMNA, GJB1, MTMR2, MPZ, NDRG1, PMP22
14axonal neuropathy29.8KIF1B, HSPB1
15charcot-marie-tooth neuropathy type 1a29.8PMP22, MPZ
16pelizaeus-merzbacher disease29.8MPZ
17x-linked disease10.8
18charcot-marie-tooth disease type 210.7
19charcot-marie-tooth disease type 110.7
20autosomal recessive disease10.6
21charcot-marie-tooth hereditary neuropathy10.6
22chromosomal disease10.5
23autosomal dominant disease10.5
24charcot-marie-tooth disease type 2b210.5
25charcot-marie-tooth disease type 1a10.5
26charcot-marie-tooth disease type 1b10.5
27charcot-marie-tooth disease type 1e10.5
28charcot-marie-tooth disease type 2b10.5
29charcot-marie-tooth disease type 2b110.5
30charcot-marie-tooth disease type 2f10.5
31charcot-marie-tooth disease type 1d10.4
32charcot-marie-tooth disease type 2c10.4
33charcot-marie-tooth disease type 2g10.4
34charcot-marie-tooth neuropathy type 4a10.4
35charcot-marie-tooth disease type 2d10.4
36charcot-marie-tooth disease type 2h10.4
37charcot-marie-tooth disease type 2j10.4
38charcot-marie-tooth disease type 2k10.4
39autosomal dominant intermediate charcot-marie-tooth disease type e10.4
40charcot-marie-tooth disease type 1c10.4
41charcot-marie-tooth disease type 1f10.4
42charcot-marie-tooth disease type 2a10.4
43charcot-marie-tooth disease type 2e10.4
44charcot-marie-tooth disease type 2i10.4
45charcot-marie-tooth disease type 410.4
46charcot-marie-tooth neuropathy type 4c10.4
47charcot-marie-tooth disease type 4b210.4
48charcot-marie-tooth disease x-linked 110.4
49hereditary sensory neuropathy10.4
50x-linked charcot-marie-tooth disease type 510.4

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Clinical Features for Tooth Disease

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Drugs & Therapeutics for Tooth Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tooth Disease

Search CenterWatch for Tooth Disease

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Tooth Disease

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Anatomical Context for Tooth Disease

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32MalaCards
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MalaCards organs/tissues related to Tooth Disease:

32
Testes, Bone, Brain, Cortex, Spinal cord, Heart, Skeletal muscle

Animal Models for Tooth Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tooth Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.5HSPB8, NDRG1, MFN2, EGR2, MPZ, MTMR2
2MP:000363110.5KIF1B, PMP22, NDRG1, MFN2, EGR2, MPZ
3MP:000538610.4PMP22, NDRG1, MFN2, EGR2, MPZ, MTMR2
4MP:000536910.2PMP22, HSPB8, NDRG1, MFN2, FIG4, LMNA

Publications for Tooth Disease

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Sources:
50PubMed
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Articles related to Tooth Disease:

(show top 50)    (show all 861)
idTitleAuthorsYear
1
The Central Nervous System Phenotype of X-Linked Charcot-Marie-Tooth Disease: A Transient Disorder of Children and Young Adults. (23400245)
2013
2
The shifting landscape of genetic testing for Charcot-Marie-Tooth disease. (24006101)
2013
3
INF2 mutations in Charcot-Marie-Tooth disease complicated with focal segmental glomerulosclerosis. (23521651)
2013
4
Compound Charcot-Marie-Tooth disease: a kindred with severe hereditary neuropathy, pupil abnormalities and a novel MPZ mutation. (23197742)
2013
5
Measuring Ankle Instability in Pediatric Charcot-Marie-Tooth Disease. (23696628)
2013
6
Management of pathological tooth migration in patients with advanced periodontal disease. (24225140)
2013
7
A pilot study of a crossover trial with randomized use of ankle-foot orthoses for people with Charcot-Marie-tooth disease. (22089961)
2012
8
Nerve conduction studies in Charcot-Marie-Tooth disease in a cohort from Turkey. (22806384)
2012
9
A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. (23141294)
2012
10
Diffusion tensor imaging and magnetic resonance spectroscopy of transient cerebral white matter lesions in X-linked Charcot-Marie-Tooth disease. (22341131)
2012
11
Gait pattern classification in children with Charcot-Marie-Tooth disease type 1A. (21944474)
2012
12
LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease. (22729949)
2012
13
A novel EGR2 mutation within a family with a mild demyelinating form of Charcot-Marie-Tooth disease. (22734907)
2012
14
X-linked dominant Charcot-Marie-Tooth disease with connexin 32 (Cx32) mutations in Koreans. (21291455)
2012
15
Mutation screening of mitofusin 2 in Charcot-Marie-Tooth disease type 2. (21258814)
2011
16
Charcot-Marie-Tooth disease. (21504497)
2011
17
A novel GJB1 frameshift mutation produces a transient CNS symptom of X-linked Charcot-Marie-Tooth disease. (20857133)
2011
18
Charcot-Marie-tooth disease and multiple malignant melanomas: a case report. (20214181)
2010
19
The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway. (20645406)
2010
20
GJB1/Connexin 32 whole gene deletions in patients with X-linked Charcot-Marie-Tooth disease. (20532933)
2010
21
Mitochondrial disease mimicking Charcot-Marie Tooth disease. (21731582)
2009
22
Phenotype and clinical evolution of Charcot-Marie-Tooth disease type 1A duplication. (20225026)
2009
23
The p.R1109X mutation in SH3TC2 gene is predominant in Spanish Gypsies with Charcot-Marie-Tooth disease type 4. (17470135)
2007
24
Axonal Charcot-Marie-Tooth disease: the fog is only slowly lifting. (17502544)
2007
25
Novel human pathological mutations. Gene symbol: GJB1. Disease: Charcot-Marie-Tooth disease 1. (18386324)
2007
26
Persistence of range of motion in dorsiflexion, when the triceps surae muscles weaken, worsens stance and gait in Charcot-Marie-Tooth disease. A case report. (17039218)
2006
27
Clinical and molecular analysis of X-linked Charcot-Marie-Tooth disease type 1 in Spanish population. (17100997)
2006
28
Charcot-marie-tooth disease: seventeen causative genes. (20396492)
2006
29
Intermittent positive airway pressure by nasal mask as a treatment for respiratory insufficiency in a patient with Charcot-Marie-Tooth disease. (17091914)
2006
30
Charcot-Marie-Tooth disease type 1A: clinicopathological correlations in 24 patients. (15703022)
2005
31
Current Therapy for Charcot-Marie-Tooth Disease. (15610704)
2005
32
Different phenotypes of Charcot-Marie-Tooth disease caused by mutations in the same gene. Are classical criteria for classification still valid?]. (15150710)
2004
33
Mutation analysis of ganglioside-induced differentiation associated protein-1 gene in Chinese Charcot-Marie-Tooth disease]. (15192818)
2004
34
Phenotypic analysis of neurofilament light gene mutations linked to Charcot-Marie-Tooth disease in cell culture models. (15282209)
2004
35
Resistance training effectiveness in patients with Charcot-Marie-Tooth disease: recommendations for exercise prescription. (15295743)
2004
36
Charcot-Marie-Tooth disease with giant axons: a clinicopathological and genetic entity. (14557576)
2003
37
Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. (12477167)
2002
38
Two amino-acid substitutions in the myelin protein zero gene of a case of Charcot-Marie-Tooth disease associated with light-near dissociation. (11801400)
2002
39
Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease. (12325071)
2002
40
Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A. (11331611)
2001
41
X-linked Charcot-Marie-Tooth disease and connexin32. (10873293)
1998
42
Four novel mutations of the connexin 32 gene in four Japanese families with Charcot-Marie-Tooth disease type 1. (9856562)
1998
43
A novel point mutation in the peripheral myelin protein 22 (PMP22) gene associated with Charcot-Marie-Tooth disease type 1A. (9040744)
1997
44
Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family. (9219740)
1997
45
Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA. (8733121)
1996
46
A new mutation of the Po gene in patients with Charcot-Marie-Tooth disease type 1B: screening of the Po gene by heteroduplex analysis. (8938258)
1996
47
A familial Charcot-Marie-Tooth disease type 1B (CMTD1B) manifesting a new mutation of myelin P0 gene]. (7537189)
1994
48
Connexin mutations in X-linked Charcot-Marie-Tooth disease. (8266101)
1993
49
Charcot-Marie-Tooth disease type 1A: mutational mechanisms and candidate gene. (8353419)
1993
50
Allelic heterogeneity in hereditary motor and sensory neuropathy type Ia (Charcot-Marie-Tooth disease type 1a). (8492918)
1993

Genetic Variations for Tooth Disease

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Expression for genes affiliated with Tooth Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for genes affiliated with Tooth Disease

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Tooth Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5GJB1, MPZ
2
Hide members
10.5FIG4, MTMR2

Compounds for genes affiliated with Tooth Disease

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44Novoseek
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Compounds related to Tooth Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arginine4410.5LMNA, GJB1, MPZ, HSPB1, PMP22
2dihydroprogesterone4410.2MPZ, PMP22

GO Terms for genes affiliated with Tooth Disease

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16Gene Ontology
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Cellular components related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5NDRG1, MFN2, NEFL, MTMR2, PRPS1, FGD4
2vacuolar membraneGO:00577410.2SBF2, MTMR2

Biological processes related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anterograde axon cargo transportGO:00808910.5KIF1B, NEFL
2myelin assemblyGO:03228810.5FIG4, MTMR2, PMP22
3negative regulation of myelinationGO:03164210.4FIG4, MTMR2
4peripheral nervous system myelin maintenanceGO:03228710.2SH3TC2, NDRG1

Molecular functions related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5KIF1B, HSPB8, HSPB1, NDRG1, MFN2, MED25

Products for genes affiliated with Tooth Disease

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  • Antibodies
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  • Antibodies

Sources for Tooth Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet