MCID: TTH006
MIFTS: 55

Tooth Disease malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Tooth Disease

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease and neuropathy. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The drugs camphor and camphor oil and the compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related mouse phenotypes are normal and behavior/neurological.

Wikipedia:65 Tooth pathology (or tooth diseases, tooth disorders or dental pathology), is any condition of the teeth... more...

Aliases & Classifications for Tooth Disease

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8Disease Ontology, 45Novoseek, 34MedlinePlus, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

tooth disease 8
dental disorder 8 45
tooth disorders 34
dental diseases 62
tooth diseases 62


External Ids:

Disease Ontology8 DOID:1091
NCIt40 C35077
MeSH35 D014076
ICD1025 K02.9

Related Diseases for Tooth Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tooth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease32.0MPZ, PMP22
2neuropathy30.7GDAP1, MFN2, PMP22, HSPB8, MPZ, NEFL
3hereditary neuropathy with liability to pressure palsies30.7PMP22
4charcot-marie-tooth disease type 4e30.6EGR2, MPZ, PMP22
5hereditary neuropathies30.6GJB1, MTMR2, MPZ, PMP22
6polyneuropathy30.3PMP22, MPZ, GJB1, EGR2
7charcot-marie-tooth disease type 330.1EGR2, GJB1, MPZ, PMP22
8multiple sclerosis30.1HSPB1, MPZ, NEFL
9pelizaeus-merzbacher disease29.9MPZ
10axonal neuropathy29.9KIF1B, HSPB1
11charcot-marie-tooth neuropathy type 1a29.9PMP22, MPZ
12neuritis29.8PMP22, MPZ
13charcot-marie-tooth neuropathy type 129.8PMP22, MPZ, NEFL, EGR2
14inherited peripheral neuropathy29.7PMP22, MPZ, GJB1, EGR2
15myopathy29.5EGR2, GJB1, MTMR2, GDAP1, MFN2, PMP22
16charcot-marie-tooth neuropathy type 229.5GDAP1, MFN2, HSPB8, HSPB1, MPZ, NEFL
17charcot-marie-tooth disease type 1a10.9
18x-linked charcot-marie-tooth disease10.7
19charcot-marie-tooth disease type 1b10.6
20charcot-marie-tooth disease type 110.6
21charcot-marie-tooth disease type 210.6
22charcot-marie-tooth disease type 2b10.5
23charcot-marie-tooth disease type 2e10.5
24charcot-marie-tooth disease type 1e10.4
25charcot-marie-tooth disease type 2b210.4
26charcot-marie-tooth disease type 2c10.4
27charcot-marie-tooth disease type 2d10.4
28charcot-marie-tooth disease type 1d10.4
29charcot-marie-tooth disease type 2a10.4
30charcot-marie-tooth disease type 2b110.4
31charcot-marie-tooth disease type 2f10.4
32charcot-marie-tooth disease type 4b110.4
33charcot-marie-tooth disease type 1c10.4
34charcot-marie-tooth disease type 2g10.4
35charcot-marie-tooth neuropathy type 4a10.4
36charcot-marie-tooth disease type 2h10.4
37charcot-marie-tooth disease type 2j10.4
38charcot-marie-tooth disease type 2k10.4
39autosomal dominant intermediate charcot-marie-tooth disease type e10.4
40charcot-marie-tooth disease x-linked 110.4
41charcot-marie-tooth disease type 1f10.4
42charcot-marie-tooth disease type 2i10.4
43charcot-marie-tooth disease type 4b210.4
44hereditary neuropathy with liability to pressure palsy10.4
45charcot-marie-tooth disease type 410.4
46x-linked charcot-marie-tooth disease type 510.4
47charcot-marie-tooth neuropathy type 4c10.3
48charcot-marie-tooth disease x-linked recessive 210.3
49charcot-marie-tooth disease x-linked recessive 310.3
50peripheral neuropathy10.3

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Symptoms for Tooth Disease

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Drugs & Therapeutics for Tooth Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Tooth Disease

Search NIH Clinical Center for Tooth Disease

Inferred drug relations via UMLS62/NDF-RT41:

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Genetic Tests for Tooth Disease

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Anatomical Context for Tooth Disease

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33MalaCards
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MalaCards organs/tissues related to Tooth Disease:

33
Testes, Bone, Brain, Spinal cord, Skeletal muscle

Animal Models for Tooth Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tooth Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2EGR2, MTMR2, NEFL, HSPB1, MFN2
2MP:00053867.5MFN2, PMP22, MPZ, MTMR2, KIF1B, GJB1
3MP:00036317.2EGR2, MFN2, PMP22, MPZ, NEFL, MTMR2
4MP:00107686.5MFN2, PMP22, HSPB8, MPZ, MTMR2, KIF1B

Publications for Tooth Disease

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Sources:
52PubMed
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Articles related to Tooth Disease:

(show top 50)    (show all 784)
idTitleAuthorsYear
1
Pain and small fiber function in Charcot Marie Tooth disease type 1A. (24395492)
2014
2
Animal models and therapeutic prospects for Charcot-Marie-Tooth disease. (23913540)
2013
3
New mutation in periaxin gene causing Charcot Marie Tooth disease in a Puerto Rican young male. (24263033)
2013
4
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. (22371199)
2012
5
A novel MPZ mutation in Charcot-Marie-Tooth disease type 1B with focally folded myelin and multiple entrapment neuropathies. (21940171)
2012
6
Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation. (22271166)
2012
7
A pilot study of a crossover trial with randomized use of ankle-foot orthoses for people with Charcot-Marie-tooth disease. (22089961)
2012
8
Goya and a possible first visual representation of Charcot-Marie-Tooth disease. (22499111)
2012
9
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
10
Inheritance of Charcot-Marie-Tooth disease 1A with rare nonrecurrent genomic rearrangement. (21193943)
2011
11
Intractable epilepsy, audio-visual hallucinations and Charcot-Marie-Tooth disease 1A in an African-American boy. (21870475)
2011
12
Charcot-Marie-Tooth disease complicating type 2 diabetes. (21817005)
2011
13
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease. (21820100)
2011
14
Copy number variations are a rare cause of non-CMT1A Charcot-Marie-Tooth disease. (19949810)
2010
15
Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. (19950375)
2010
16
Novel FH mutation in a patient with cutaneous leiomyomatosis associated with cutis verticis gyrata, eruptive collagenoma and Charcot-Marie-Tooth disease. (20560959)
2010
17
Charcot-Marie-Tooth disease. (19277060)
2009
18
Molecular diagnosis of axonal forms of Charcot-Marie-Tooth disease]. (19942244)
2009
19
Mitochondrial disease mimicking Charcot-Marie Tooth disease. (21731582)
2009
20
Poor compliance with ankle-foot-orthoses in Charcot-Marie-Tooth disease. (18385625)
2008
21
Charcot-Marie-Tooth disease and the cavovarus foot. (18457773)
2008
22
Neurophysiologic abnormalities in children with Charcot-Marie-Tooth disease type 1A. (18844790)
2008
23
Phosphoinositides and Charcot-Marie-tooth disease: new keys to old questions. (17965826)
2007
24
Anesthetic management of a parturient with neurofibromatosis 1 and Charcot-Marie-Tooth disease. (17869996)
2007
25
Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance. (17294201)
2007
26
Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1. (17881652)
2007
27
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. (16452125)
2006
28
Gene symbol: MPZ. Disease: Charcot-Marie-Tooth disease. Accession #Hm0551. (17297707)
2006
29
Prevalence of Charcot-Marie-Tooth disease in patients who have bilateral cavovarus feet. (16791058)
2006
30
A novel out-of-frame mutation in the neurofilament light chain gene (NEFL) does not result in Charcot-Marie-Tooth disease type 2E. (15654615)
2005
31
Autosomal-recessive Charcot-Marie-Tooth diseases. (15892292)
2005
32
An animal model for Charcot-Marie-Tooth disease type 4B1. (16249189)
2005
33
Charcot-Marie-Tooth disease type 1A with central nervous system involvement in two generations. (15083299)
2004
34
Charcot-Marie-Tooth disease type 1A: a clinical, electrophysiological, pathological, and genetic study. (15239197)
2004
35
Central neural blockade in Charcot-Marie-Tooth disease. (15574563)
2004
36
Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A? (15363066)
2004
37
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. (15122254)
2004
38
Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. (14561495)
2003
39
Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. (12477167)
2002
40
A second locus for an axonal form of autosomal recessive Charcot-Marie-Tooth disease maps to chromosome 19q13.3. (11112660)
2001
41
The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (10369162)
1999
42
Charcot-Marie-Tooth disease with intermediate motor nerve conduction velocities: characterization of 14 Cx32 mutations in 35 families. (9401007)
1997
43
Novel mutation of the myelin Po gene in a pedigree with Charcot- Marie-Tooth disease type 1B. (9217235)
1997
44
Normalized Southern Hybridization to Enhance Testing for Charcot-Marie-Tooth Disease, Type 1A. (10330199)
1996
45
Mosaicism for the Charcot-Marie-Tooth disease type 1A duplication suggests somatic reversion. (8682501)
1996
46
Arginine-164-tryptophan substitution in connexin32 associated with X linked dominant Charcot-Marie-Tooth disease. (8733054)
1996
47
Phenotypic heterogeneity in Japanese Charcot-Marie-Tooth disease type 1A patients with PMP-22 gene duplication]. (8821490)
1995
48
Mutations in the connexin 32 gene in X-linked dominant Charcot-Marie- Tooth disease (CMTX1). (8162049)
1994
49
Linkage and mutation analysis in an extended family with Charcot- Marie-Tooth disease type 1B. (7530774)
1994
50
Progressive muscular atrophy of the peroneal type (Charcot-Marie-Tooth disease) orthopaedic management and end-result study. (15401720)
1950

Variations for Tooth Disease

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Expression for genes affiliated with Tooth Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for genes affiliated with Tooth Disease

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Tooth Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3GJB1, MPZ, PMP22

Compounds for genes affiliated with Tooth Disease

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Tooth Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dihydroprogesterone4510.0MPZ, PMP22
2ganglioside459.5MPZ, PMP22
3dbc-amp459.5EGR2, HSPB1
4forskolin45 51 1110.9PMP22, HSPB1, GJB1
5progesterone45 29 61 24 1112.9GJB1, MPZ, HSPB1, PMP22
6arginine458.9PMP22, HSPB1, MPZ, GJB1
7cysteine458.7GJB1, MPZ, HSPB1, PMP22
8retinoic acid45 249.7PMP22, HSPB1, NEFL, GJB1
9tyrosine458.3EGR2, GJB1, MTMR2, MPZ, HSPB1

GO Terms for genes affiliated with Tooth Disease

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16Gene Ontology
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Biological processes related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin assemblyGO:0322889.7MTMR2, PMP22
2peripheral nervous system developmentGO:0074229.7PMP22, EGR2
3anterograde axon cargo transportGO:0080899.6KIF1B, NEFL
4synaptic transmissionGO:0072689.5NEFL, MPZ, PMP22
5protein targeting to mitochondrionGO:0066269.5MFN2, GDAP1
6cell deathGO:0082198.7HSPB1, HSPB8, MFN2

Molecular functions related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6EGR2, KIF1B, MTMR2, NEFL, HSPB1, HSPB8

Products for genes affiliated with Tooth Disease

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  • Antibodies
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  • Antibodies

Sources for Tooth Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet