MCID: TTH006
MIFTS: 55

Tooth Disease malady

Gastrointestinal diseases category

Summaries for Tooth Disease

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Your teeth are made of a hard, bonelike material. inside the tooth are nerves and blood vessels. you need your teeth for many activities you may take for granted. these include eating, speaking and even smiling. but tooth disorders are nothing to smile about. they include problems such as cavities (also known as tooth decay), infections, and injuries. the most familiar symptom of a tooth problem is a toothache. others include worn-down or loose teeth. it's important that you see a dentist if you have any problems with your teeth. fortunately, you can prevent many tooth disorders by taking care of your teeth and keeping them clean.

MalaCards: Tooth Disease, also known as dental disorder, is related to charcot-marie-tooth disease and neuropathy. An important gene associated with Tooth Disease is MPZ (myelin protein zero), and among its related pathways are Neural Crest Differentiation and Synthesis of PIPs at the early endosome membrane. The drugs camphor and camphor oil and the compounds arginine and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and spinal cord, and related mouse phenotypes are mortality/aging and nervous system.

Wikipedia:63 Tooth pathology (or tooth diseases, tooth disorders or dental pathology), is any condition of the teeth... more...

Aliases & Classifications for Tooth Disease

About this section
Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

tooth disease 8
dental disorder 8 44
tooth disorders 33
dental diseases 60
tooth diseases 60


External Ids:

Disease Ontology8 DOID:1091
NCIt39 C35077
MeSH34 D014076
ICD1025 K02.9

Related Diseases for Tooth Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Tooth Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease31.9MPZ, PMP22
2neuropathy31.1LMNA, GJB1, SBF2, GDAP1, FIG4, LITAF
3charcot-marie-tooth disease type 4b130.6MTMR2, SBF2
4hereditary neuropathy with liability to pressure palsies30.6PMP22
5charcot-marie-tooth disease type 4e30.5MPZ, EGR2, PMP22
6peripheral neuropathy30.5NDRG1
7charcot-marie-tooth neuropathy type 130.3LITAF, NEFL, MPZ, EGR2, PMP22
8polyneuropathy30.3PMP22, NDRG1, EGR2, MPZ, GJB1
9charcot-marie-tooth disease type 330.1GJB1, MPZ, EGR2, PMP22
10charcot-marie-tooth neuropathy type 230.0MFN2, HSPB1, HSPB8, MPZ, NEFL, GDAP1
11myopathy30.0FIG4, SH3TC2, MTMR2, NEFL, MPZ, EGR2
12amyotrophic lateral sclerosis30.0NEFL, HSPB1
13hereditary neuropathies29.8LMNA, GJB1, MTMR2, MPZ, NDRG1, PMP22
14axonal neuropathy29.8KIF1B, HSPB1
15charcot-marie-tooth neuropathy type 1a29.8PMP22, MPZ
16pelizaeus-merzbacher disease29.8MPZ
17x-linked disease10.8
18charcot-marie-tooth disease type 210.7
19charcot-marie-tooth disease type 110.7
20autosomal recessive disease10.6
21charcot-marie-tooth hereditary neuropathy10.6
22chromosomal disease10.5
23autosomal dominant disease10.5
24charcot-marie-tooth disease type 2b210.5
25charcot-marie-tooth disease type 1a10.5
26charcot-marie-tooth disease type 1b10.5
27charcot-marie-tooth disease type 1e10.5
28charcot-marie-tooth disease type 2b10.5
29charcot-marie-tooth disease type 2b110.5
30charcot-marie-tooth disease type 2f10.5
31charcot-marie-tooth disease type 1d10.4
32charcot-marie-tooth disease type 2c10.4
33charcot-marie-tooth disease type 2g10.4
34charcot-marie-tooth neuropathy type 4a10.4
35charcot-marie-tooth disease type 2d10.4
36charcot-marie-tooth disease type 2h10.4
37charcot-marie-tooth disease type 2j10.4
38charcot-marie-tooth disease type 2k10.4
39autosomal dominant intermediate charcot-marie-tooth disease type e10.4
40charcot-marie-tooth disease type 1c10.4
41charcot-marie-tooth disease type 1f10.4
42charcot-marie-tooth disease type 2a10.4
43charcot-marie-tooth disease type 2e10.4
44charcot-marie-tooth disease type 2i10.4
45charcot-marie-tooth disease type 410.4
46charcot-marie-tooth neuropathy type 4c10.4
47charcot-marie-tooth disease type 4b210.4
48charcot-marie-tooth disease x-linked 110.4
49hereditary sensory neuropathy10.4
50x-linked charcot-marie-tooth disease type 510.4

Graphical network of the top 20 diseases related to Tooth Disease:



Diseases related to tooth disease

Clinical Features for Tooth Disease

About this section

Drugs & Therapeutics for Tooth Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Tooth Disease

Drug clinical trials:

Search ClinicalTrials for Tooth Disease

Search NIH Clinical Center for Tooth Disease

Search CenterWatch for Tooth Disease

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Genetic Tests for Tooth Disease

About this section

Anatomical Context for Tooth Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Tooth Disease:

32
Testes, Bone, Spinal cord, Brain, Heart, Skeletal muscle, Cortex

Animal Models for Tooth Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Tooth Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.5LMNA, GJB1, FIG4, MTMR2, MPZ, EGR2
2MP:000363110.5NEFL, MPZ, KIF1B, LMNA, GJB1, EGR2
3MP:000538610.4MTMR2, NDRG1, MFN2, EGR2, MPZ, SH3TC2
4MP:000536910.2HSPB8, NDRG1, MFN2, FIG4, KIF1B, PMP22

Publications for Tooth Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Tooth Disease:

(show top 50)    (show all 861)
idTitleAuthorsYear
1
Charcot-Marie-Tooth Disease: An Overview of Genotypes, Phenotypes, and Clinical Management Strategies. (24434692)
2014
2
Patient identification of the symptomatic impact of charcot-marie-tooth disease type 1A. (23965405)
2013
3
Late-onset Charcot-Marie-Tooth disease type 1B due to a novel mutation in the extracellular disulfide bridge of MPZ gene. (22633464)
2013
4
A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation. (23950871)
2013
5
Vestibular impairment in patients with Charcot-Marie-tooth disease. (23658384)
2013
6
Charcot-Marie-Tooth disease: frequency of genetic subtypes in a German neuromuscular center population. (23743332)
2013
7
A family with IVIg-responsive Charcot-Marie-Tooth disease. (23232577)
2013
8
Anaesthetic management of a patient with Charcot-Marie-Tooth disease for staged diaphragmatic plication. (23687324)
2013
9
McGill researcher identifies protein involved in rare bone and tooth disease. (23522125)
2013
10
Charcot-Marie-Tooth disease presenting as a nonhealing ulcer in a 26-year-old man. (22371199)
2012
11
Exploring the experience of fatigue in people with Charcot-Marie-Tooth disease. (23182641)
2012
12
A multidisciplinary approach for the management of pathologic tooth migration in a patient with moderately advanced periodontal disease. (22292151)
2012
13
Neural and molecular features on Charcot-Marie-Tooth disease plasticity and therapy. (22745917)
2012
14
Hypertelorism in Charcot-Marie-Tooth disease 1A from the common PMP22 duplication: A Case Report. (22496945)
2012
15
A novel MPZ gene mutation in exon 2 causing late-onset demyelinating Charcot-Marie-Tooth disease. (22622165)
2012
16
Symmetry of foot alignment and ankle flexibility in paediatric Charcot-Marie-Tooth disease. (22424781)
2012
17
MPZ mutation in an early-onset Charcot-Marie-Tooth disease type 1B family by genome-wide linkage analysis. (21503568)
2011
18
Charcot-Marie-Tooth disease subtypes and genetic testing strategies. (21280073)
2011
19
Novel mutations in the PRX and the MTMR2 genes are responsible for unusual Charcot-Marie-Tooth disease phenotypes. (21741241)
2011
20
Central nervous system involvement in axonal Charcot-Marie-Tooth disease. (19813192)
2010
21
Six new gap junction beta 1 gene mutations and their phenotypic expression in Czech patients with Charcot-Marie-Tooth disease. (20039784)
2010
22
Anesthetic management of an obstetric patient with Charcot-Marie-Tooth disease: a case study. (19911641)
2009
23
Two novel mutations of GJB1 gene associated with typical X-linked Charcot-Marie-Tooth disease]. (20193560)
2009
24
Acromial stress fracture in a young wheelchair user with Charcot-Marie-Tooth disease: a case report. (19040744)
2008
25
Myoclonic seizures in a patient with Charcot-Marie-tooth disease. (17275665)
2007
26
Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease. (16881064)
2006
27
Peroneal nerve branching suggests compression palsy in the deformities of Charcot-Marie Tooth disease. (16906063)
2006
28
Is a novel I214M substitution in the NEFL gene a cause of Charcot-Marie-Tooth disease? Functional analysis using cell culture models. (16930284)
2006
29
Animal models of Charcot-Marie-Tooth disease type 1A. (16775377)
2006
30
GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria. (15772096)
2005
31
Phrenic nerve involvement in Charcot-Marie-Tooth disease. (16294569)
2005
32
Disease course of Charcot-Marie-Tooth disease type 2 and comorbidity. (15364699)
2004
33
A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (15146389)
2004
34
Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. (14561495)
2003
35
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. (12690580)
2003
36
Gap junction protein beta 1 (GJB1) mutations and central nervous system symptoms in X-linked Charcot-Marie-Tooth disease. (12542510)
2003
37
Analysis of mutations in the chromosome 17p11.2 region in patients with Charcot-Marie-Tooth type 1 disease and in patients with tomaculous neuropathy]. (12154515)
2002
38
A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. (10841809)
2000
39
Axonal phenotype of Charcot-Marie-Tooth disease associated with a mutation in the myelin protein zero gene. (10329755)
1999
40
Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease. (10384882)
1999
41
Charcot-Marie-Tooth disease and Noonan syndrome with giant proximal nerve hypertrophy. (9566396)
1998
42
Significance of facial and trigeminal nerve involvement in Charcot-Marie-Tooth disease type 1A: a case report. (9655140)
1998
43
Mosaicism for the Charcot-Marie-Tooth disease type 1A duplication suggests somatic reversion. (8682501)
1996
44
Two novel mutations (C53S, S26L) in the connexin32 of Charcot-Marie- Tooth disease type X families. (8889588)
1996
45
Charcot-Marie-Tooth disease type 1A: morphological phenotype of the 17p duplication versus PMP22 point mutations. (8615087)
1995
46
Frequency of duplication at 17p11.2 in families of northeast Italy with Charcot-Marie-Tooth disease type 1. (7891814)
1995
47
Charcot-Marie-Tooth disease type 1A, 9 November 1992, San Francisco, CA, U.S.A. (8329893)
1993
48
Pregnancy and delivery in Charcot-Marie-Tooth disease type 1. (8413959)
1993
49
Charcot-Marie-Tooth disease type 1. (1552540)
1992
50
A yeast artificial chromosome contig spanning the Charcot-Marie-Tooth disease type 1A duplication region. (1301169)
1992

Genetic Variations for Tooth Disease

About this section

Expression for genes affiliated with Tooth Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tooth Disease

Search GEO for disease gene expression data for Tooth Disease.

Pathways for genes affiliated with Tooth Disease

About this section
Sources:
37NCBI BioSystems Database, 53Reactome
See all sources

Pathways related to Tooth Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5GJB1, MPZ
2
Hide members
10.5FIG4, MTMR2

Compounds for genes affiliated with Tooth Disease

About this section
Sources:
44Novoseek
See all sources

Compounds related to Tooth Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arginine4410.5LMNA, GJB1, MPZ, HSPB1, PMP22
2dihydroprogesterone4410.2MPZ, PMP22

GO Terms for genes affiliated with Tooth Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5NDRG1, MFN2, NEFL, MTMR2, PRPS1, FGD4
2vacuolar membraneGO:00577410.2SBF2, MTMR2

Biological processes related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anterograde axon cargo transportGO:00808910.5KIF1B, NEFL
2myelin assemblyGO:03228810.5FIG4, MTMR2, PMP22
3negative regulation of myelinationGO:03164210.4FIG4, MTMR2
4peripheral nervous system myelin maintenanceGO:03228710.2SH3TC2, NDRG1

Molecular functions related to Tooth Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5KIF1B, HSPB8, HSPB1, NDRG1, MFN2, MED25

Products for genes affiliated with Tooth Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tooth Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet