MCID: TRC034
MIFTS: 22

Torch Syndrome malady

Summaries for Torch Syndrome

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33MalaCards
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MalaCards: Torch Syndrome is related to pseudo-torch syndrome and aicardi-goutieres syndrome. An important gene associated with Torch Syndrome is OCLN (occludin), and among its related pathways are Cell adhesion molecules (CAMs) and Tight junction. The compounds uridine and pseudouridine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Torch Syndrome

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

torch syndrome 43 61


Related Diseases for Torch Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases in the pseudo-torch syndrome family:

torch syndrome

Diseases related to Torch Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1pseudo-torch syndrome30.8DKC1, OCLN, JAM3, COL4A1
2aicardi-goutieres syndrome10.2
3char syndrome10.1
4aicardi-goutieres syndrome 1, dominant and recessive10.1
5aplastic anemia10.0TERC
6dyskeratosis congenita autosomal dominant10.0TERC, DKC1
7leukoplakia10.0TERC, DKC1
8dyskeratosis congenita10.0TERC, DKC1

Graphical network of diseases related to Torch Syndrome:



Diseases related to torch syndrome

Clinical Features for Torch Syndrome

Drugs & Therapeutics for Torch Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Torch Syndrome

Drug clinical trials:

Search ClinicalTrials for Torch Syndrome

Search NIH Clinical Center for Torch Syndrome

Search CenterWatch for Torch Syndrome

Genetic Tests for Torch Syndrome

Anatomical Context for Torch Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Torch Syndrome:

33
Brain

Animal Models for Torch Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Torch Syndrome

Sources:
51PubMed
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Articles related to Torch Syndrome:

idTitleAuthorsYear
1
The relationship between TORCH complex false positivity and obstetric outcome in patients with antiphospholipid syndrome. (22635229)
2012
2
Microcephaly, malformation of brain development and intracranial calcification in sibs: pseudo-TORCH or a new syndrome. (18925673)
2008
3
Chorioretinal dysplasia, hydranencephaly, and intracranial calcifications: pseudo-TORCH or a new syndrome? (18084237)
2008
4
Two brothers with findings resembling congenital intrauterine infection-like syndrome (pseudo-TORCH syndrome). (12833411)
2003
5
Pseudo-TORCH syndrome or Baraitser-Reardon syndrome: diagnostic criteria. (11226724)
2001
6
TORCH syndrome. (7640200)
1995
7
TORCH syndrome and TORCH screening. (1972489)
1990
8
Charts: the TORCH syndrome revisited. (2922243)
1989
9
The TORCH syndrome: a clinical review. (2985660)
1985
10
The "torch syndrome. (177938)
1976

Genetic Variations for Torch Syndrome

Expression for genes affiliated with Torch Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Torch Syndrome

Search GEO for disease gene expression data for Torch Syndrome.

Pathways for genes affiliated with Torch Syndrome

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore
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Pathways related to Torch Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2OCLN, JAM3
29.2OCLN, JAM3
39.2JAM3, OCLN
4
Hide members
8.7OCLN, JAM3, COL4A1
5
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
8.7OCLN, JAM3, COL4A1

Compounds for genes affiliated with Torch Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Torch Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1uridine45 11 2411.3TERC, DKC1
2pseudouridine45 2410.2TERC, DKC1
3rrna459.0TERC, DKC1

GO Terms for genes affiliated with Torch Syndrome

Sources:
16Gene Ontology
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Cellular components related to Torch Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tight junctionGO:0059239.2OCLN, JAM3

Biological processes related to Torch Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiogenesisGO:0015259.1JAM3, COL4A1

Products for genes affiliated with Torch Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Torch Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet