Toxic Diffuse Goiter disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Toxic Diffuse Goiter

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MalaCards: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The compounds chromium and carbimazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Classifications for Toxic Diffuse Goiter

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⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ²⁷ICD9CM
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Aliases & Descriptions:

toxic diffuse goiter ⁸ ¹⁰ ⁴⁴ ⁶⁰

External Ids:

Disease Ontology⁸ DOID:10719

ICD9CM²⁷ 242.00

UMLS⁶⁰ C0154138

Related Diseases for Toxic Diffuse Goiter

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¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)

id	Related Disease	Score	Top Affiliating Genes
1	goiter	31.2	TSHR, TG, TPO
2	graves' disease	30.7	TPO, TG, TSHR
3	thyrotoxicosis	30.4	TG, TPO, TSHR
4	thyroiditis	30.4	TSHR, TPO, TG
5	nodular goiter	30.2	TSHR, TPO, TG
6	hypothyroidism	30.2	TG, TPO, TSHR
7	adenoma	30.2	TG, TSHR, TPO
8	subacute thyroiditis	10.0	TG
9	hyperthyroxinemia	10.0	TSHR, TPO
10	viral hepatitis	10.0	TSHR
11	pernicious anemia	10.0	TG, TPO
12	plummer's disease	10.0	TG, TPO
13	thyrotropin deficiency, isolated	10.0	TPO, TG
14	autoimmune thyroiditis	10.0	TG, TPO
15	pendred syndrome	10.0	TPO, TG
16	down syndrome	10.0	TSHR, TPO
17	thyroid agenesis	10.0	TSHR, TG
18	struma ovarii	10.0	TG, TSHR
19	celiac disease	10.0	TPO, TG
20	turner syndrome	10.0	TPO, TG
21	follicular thyroid carcinoma	10.0	TSHR, TG
22	pregnancy loss	10.0	TG, TPO
23	addison's disease	10.0	TG, TPO
24	nontoxic goiter	10.0	TPO, TG, TSHR
25	endemic goiter	10.0	TSHR, TPO, TG
26	myxedema	10.0	TPO, TSHR, TG
27	multinodular goiter	10.0	TPO, TG, TSHR
28	thyroid cancer, anaplastic	10.0	TG, TPO, TSHR
29	follicular adenoma	10.0	TPO, TSHR, TG
30	congenital hypothyroidism	10.0	TPO, TG, TSHR
31	thyroid adenoma	10.0	TPO, TSHR, TG
32	papillary carcinoma	10.0	TG, TPO, TSHR
33	papillary thyroid carcinoma	10.0	TG, TPO, TSHR
34	type 1 diabetes	10.0	TPO, TG, TSHR
35	hyperthyroidism	10.0	TPO, TG, TSHR
36	hypersensitivity reaction type ii disease	10.0	TG, TPO, TSHR
37	thyroid cancer	10.0	TPO, TG, TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:

Clinical Features for Toxic Diffuse Goiter

Drugs & Therapeutics for Toxic Diffuse Goiter

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⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
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Approved drugs:

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Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

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³²MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

³²

Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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³⁶MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.0	TG, TPO, TDG, TSHR
2	growth/size phenotype	MP:0005378	7.7	TG, TPO, TDG, TSHR

Publications for Toxic Diffuse Goiter

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⁵⁰PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 31)

id	Title	Authors	Year
1	Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)	Savchenko O.V.... Toupeleev P.A.	2012
2	The predictive role of 24h RAIU with respect to the outcome of low fixed dose radioiodine therapy in patients with diffuse toxic goiter. (23422768)	Damle N.... Virkar D.	2012
3	Correlation between serum leptin levels and insulin sensitivity in diffuse toxic goiter. (15098916)	Tene PAcrez C.E.... Islas-Andrade S.	2004
4	Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)	Cardoso L.C.... Carvalho D.P.	2002
5	Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)	Hosaka Y.... Hosoya T.	1993
6	Osteocalcin in diffuse toxic goiter]. (1377070)	Balabolkin M.I.... Mkrtumian A.M.	1992
7	Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter]. (1658772)	Mkrtumova N.A.... Kandror V.I.	1991
8	The presence of antithyroid antibodies in the blood serum of patients with diffuse toxic goiter before and during treatment]. (2080137)	Khalling T.A.... Iarvekiul'g L.V.	1990
9	Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)	Kamel N.... Polat H.	1988
10	Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)	Ericsson U.B.... Thorell J.I.	1987
11	HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)	Schleusener H.... Wenzel K.W.	1983
12	Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)	Heggi F.N.	1981
13	Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)	Steinbach J.J.... Goldman J.K.	1979
14	The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)	Von Hofe S.E.... Young R.L.	1978
15	The choice of therapy in toxic diffuse goiter. (80165)	Young R.L.... Dorfman S.G.	1978
16	Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)	Nagataki S.... Masuyama Y.	1977
17	Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)	Barnes H.V.... Blizzard R.M.	1977
18	Functional state of the stomach in patients with diffuse toxic goiter and hypothyroidism]. (1173954)	Mukhamadieva G.A.	1975
19	I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)	Yang H.F.	1972
20	I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)	Yang H.F.	1971
21	Treatment of toxic diffuse goiter. (4183010)	Stanbury J.B.	1969
22	I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)	Yang H.F.... Chen C.C.	1969
23	Toxic diffuse goiter in children. (5819609)	Mosier H.D.	1969
24	Induction of myxedema by iodide in patients euthyroid after radioiodin or surgical treatment of diffuse toxic goiter. (4980221)	Braverman L.E.... Ingbar S.H.	1969
25	The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)	BLOOMFIELD A.L.	1957
26	Chronic treatment of toxic diffuse goiter. (13457490)	REVENO W.S.... Rosenbaum H.	1957
27	Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)	SELIGMAN B.	1952
28	Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)	Topper A.	1951
29	Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)	GREENBERG S.U.... BRUGER M.	1950
30	Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)	PRINZMETAL M.... AGRESS C.M.	1949
31	The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)	McKNIGHT R.B.	1946

Genes related to Toxic Diffuse Goiter

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Toxic Diffuse Goiter:

id	Symbol	Description	Score	Implication
1	TPO	thyroid peroxidase	22.69	GeneCards inferred : Publications, Disorders (show sections)
2	TSHR	thyroid stimulating hormone receptor	17.69	GeneCards inferred : Disorders (show sections)
3	TG	thyroglobulin	12.69	GeneCards inferred : Disorders (show sections)
4	TDG	thymine-DNA glycosylase	7.56	GeneCards inferred : Disorders (show sections)

Products for genes related to Toxic Diffuse Goiter disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	4	4	4
2	LSBio	-	-	4

Genetic Variations for Toxic Diffuse Goiter

Expression for genes affiliated with Toxic Diffuse Goiter

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¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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²⁹KEGG
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Pathways related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Insulin secretion²⁹ Hide members Thyroid hormone synthesis²⁹	9.1	TG, TPO
2	Allograft rejection²⁹ Hide members Autoimmune thyroid disease²⁹	8.5	TG, TPO, TSHR

Compounds for genes affiliated with Toxic Diffuse Goiter

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⁴⁴Novoseek, ¹¹DrugBank, ²⁴HMDB, ⁴⁹PharmGKB, ²⁸IUPHAR, ²BitterDB, ⁵⁹Tocris Bioscience
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Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	chromium⁴⁴	10.3	TPO
2	carbimazole⁴⁴ ¹¹	10.7	TPO, TSHR
3	amino acid⁴⁴	9.7	TSHR, TPO
4	maltose⁴⁴ ¹¹	10.7	TSHR, TPO
5	asparagine⁴⁴	9.6	TPO, TSHR
6	cytosine⁴⁴ ²⁴	10.6	TDG, TSHR
7	iodotyrosine⁴⁴ ²⁴	10.5	TG, TPO
8	diiodotyrosine⁴⁴	9.5	TPO, TG
9	perchlorate⁴⁴	9.5	TG, TPO
10	gliadin⁴⁴	9.5	TG, TPO
11	amiodarone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.5	TG, TPO
12	cardiolipin⁴⁴ ¹¹	10.5	TPO, TG
13	selenium⁴⁴ ²⁴	10.4	TG, TPO
14	adenine⁴⁴ ¹¹ ²⁴	11.4	TDG, TSHR
15	sodium dodecylsulfate⁴⁴	9.4	TG, TPO
16	hydrocortisone⁴⁴ ² ⁵⁹ ¹¹	12.4	TG, TPO
17	gold⁴⁴	9.3	TG, TPO
18	prednisolone⁴⁴ ²⁸ ¹¹	11.3	TSHR, TG
19	sialic acid⁴⁴	9.2	TSHR, TG
20	agarose⁴⁴	9.0	TSHR, TPO
21	mannose⁴⁴	9.0	TG, TSHR
22	sodium iodide⁴⁴	8.9	TG, TPO, TSHR
23	propylthiouracil⁴⁴ ² ¹¹	10.9	TG, TPO, TSHR
24	iodine⁴⁴ ²⁴	9.9	TSHR, TPO, TG
25	carbohydrates⁴⁴	8.9	TSHR, TG
26	125i⁴⁴	8.9	TG, TPO, TSHR
27	iodide⁴⁴ ²⁴	9.9	TSHR, TPO, TG
28	methimazole⁴⁴ ² ¹¹	10.9	TG, TPO, TSHR
29	triiodothyronine⁴⁴	8.9	TG, TPO, TSHR
30	thyroxine⁴⁴ ²⁴	9.9	TSHR, TPO, TG
31	guanine⁴⁴ ¹¹ ²⁴	10.9	TSHR, TDG, TG
32	ribonucleic acid⁴⁴	8.9	TG, TPO, TSHR
33	polysaccharide⁴⁴	8.9	TG, TPO, TSHR
34	sodium⁴⁴ ²⁴	9.8	TG, TPO, TSHR
35	aspartate⁴⁴	8.8	TSHR, TPO, TG
36	adenylate⁴⁴	8.8	TG, TPO, TSHR
37	arginine⁴⁴	8.8	TSHR, TPO, TG
38	glutamate⁴⁴	8.8	TSHR, TPO, TG
39	estrogen⁴⁴	8.7	TG, TDG, TSHR
40	retinoic acid⁴⁴ ²⁴	9.6	TSHR, TPO, TG
41	cysteine⁴⁴	8.5	TG, TPO, TSHR