MCID: TXC004
MIFTS: 29

Toxic Diffuse Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

About this section

Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 10 47 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:10719
ICD9CM29 242.00
UMLS65 C0154138, C0342122

Summaries for Toxic Diffuse Goiter

About this section
MalaCards based summary: Toxic Diffuse Goiter is related to goiter and hypothyroidism. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, pituitary and liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Related Diseases for Toxic Diffuse Goiter

About this section

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.6SERPINA7, TG
2hypothyroidism30.5TG, TRH
3thyroiditis30.4TG, TPO, TSHR
4graves' disease11.9
5autoimmune thyroiditis10.6TG, TPO
6thyroid ectopia10.6TG, TPO
7neonatal meningitis10.6TG, TPO
8rhabdomyosarcoma, embryonal, 210.6TG, TPO
9solar retinopathy10.5TG, TPO
10chronic inflammatory demyelinating polyradiculoneuropathy10.5TG, TSHR
11iatrogenic or traumatic pituitary deficiency10.5TG, TSHR
12setariasis10.5TG, TPO
13riedel's fibrosing thyroiditis10.5TG, TRH
14perivascular epithelioid cell tumor10.5TG, TSHR
15hypothryoidism, congenital, nongoitrous 410.5TG, TPO
16megaloblastic anemia10.5TG, TPO
17laryngeal mucoepidermoid carcinoma10.3CALCA, TG
18fuchs' heterochromic uveitis10.3TG, TSHR
19glaucoma, primary open angle, juvenile-onset, 210.3TG, TPO
20skin angiosarcoma10.3CALCA, TG
21hypophosphatemia10.3TG, TPO, TSHR
22familial abdominal aortic aneurysm10.3TG, TPO, TSHR
23hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.3SERPINA7, TG, TSHR
24deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.3TG, TPO
25scabies10.3CALCA, TG
26corneal ectasia10.2CALCA, TG
27rh isoimmunization10.2TG, TPO, TSHR
28chest wall lymphoma10.2CALCA, TG
29thyroid hormone resistance10.2SERPINA7, TRH
30euthyroid sick syndrome10.2SERPINA7, TPO, TRH
31hypoaldosteronism10.2CALCA, TG
32ovarian cyst10.1CALCA, TG
33bone cancer10.1CALCA, TG, TPO
34ovarian endometrioid cystadenoma10.1CALCA, TG, TPO
35pituitary adenoma10.0SERPINA7, TRH
36accommodative spasm10.0SERPINA7, TG, TPO, TSHR
37thyrotoxic exophthalmos10.0SERPINA7, TG, TPO, TSHR
38ulcerative blepharitis9.9CALCA, TPO
39nodular goiter9.8
40adenoma9.8
41lingual goiter9.7CALCA, TG, TPO, TSHR
42endemic goiter9.7CALCA, TG, TPO, TSHR
43parenchymatous neurosyphilis9.7CALCA, TG, TPO, TSHR
44mediastinal osteogenic sarcoma9.7CALCA, TG, TPO, TSHR
45hashimoto thyroiditis9.7CALCA, TG, TPO, TSHR
46frontotemporal dementia and/or amyotrophic lateral sclerosis 49.7CALCA, TG, TPO, TSHR
47chorea, hereditary benign9.7CALCA, TG, TPO, TSHR
48adrenal rest tumor9.7CALCA, TG, TPO, TSHR
49hypertelorism, preauricular sinus, punctal pits, and deafness9.6SERPINA7, TG, TPO, TRH, TSHR
50tinea corporis9.6SERPINA7, TG, TPO, TRH, TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

About this section

Drugs & Therapeutics for Toxic Diffuse Goiter

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

About this section

Anatomical Context for Toxic Diffuse Goiter

About this section

MalaCards organs/tissues related to Toxic Diffuse Goiter:

33
Thyroid, Pituitary, Liver, Bone, Lung, Skin, Breast

Animal Models for Toxic Diffuse Goiter or affiliated genes

About this section

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ABCA1, TG, TNFRSF25, TPO, TRH, TSHR
2MP:00053977.2ABCA1, F3, PTN, TG, TNFRSF25, TPO

Publications for Toxic Diffuse Goiter

About this section

Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

About this section

Expression for genes affiliated with Toxic Diffuse Goiter

About this section
Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

About this section

Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5TG, TPO, TSHR
29.1TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

About this section

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.0TG, TPO
2thyroid hormone generationGO:00065909.8TG, TPO
3response to low-density lipoprotein particleGO:00550989.6ABCA1, F3
4positive regulation of cAMP biosynthetic processGO:00308199.4ABCA1, CALCA
5activation of adenylate cyclase activityGO:00071909.2CALCA, TSHR

Sources for Toxic Diffuse Goiter

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet