Toxic Diffuse Goiter disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Toxic Diffuse Goiter

Sources:
¹⁰Disease Ontology, ⁴⁷Novoseek, ¹²DISEASES, ⁶⁵UMLS, ²⁹ICD9CM
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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter ¹⁰ ⁴⁷ ¹² ⁶⁵

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹⁰ DOID:10719

ICD9CM²⁹ 242.00

UMLS⁶⁵ C0154138, C0342122

Summaries for Toxic Diffuse Goiter

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³³MalaCards
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MalaCards based summary: Toxic Diffuse Goiter is related to goiter and hypothyroidism. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, pituitary and liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Related Diseases for Toxic Diffuse Goiter

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)

id	Related Disease	Score	Top Affiliating Genes
1	goiter	31.6	SERPINA7, TG
2	hypothyroidism	30.5	TG, TRH
3	thyroiditis	30.4	TG, TPO, TSHR
4	graves' disease	11.9
5	autoimmune thyroiditis	10.6	TG, TPO
6	thyroid ectopia	10.6	TG, TPO
7	neonatal meningitis	10.6	TG, TPO
8	rhabdomyosarcoma, embryonal, 2	10.6	TG, TPO
9	solar retinopathy	10.5	TG, TPO
10	chronic inflammatory demyelinating polyradiculoneuropathy	10.5	TG, TSHR
11	iatrogenic or traumatic pituitary deficiency	10.5	TG, TSHR
12	setariasis	10.5	TG, TPO
13	riedel's fibrosing thyroiditis	10.5	TG, TRH
14	perivascular epithelioid cell tumor	10.5	TG, TSHR
15	hypothryoidism, congenital, nongoitrous 4	10.5	TG, TPO
16	megaloblastic anemia	10.5	TG, TPO
17	laryngeal mucoepidermoid carcinoma	10.3	CALCA, TG
18	fuchs' heterochromic uveitis	10.3	TG, TSHR
19	glaucoma, primary open angle, juvenile-onset, 2	10.3	TG, TPO
20	skin angiosarcoma	10.3	CALCA, TG
21	hypophosphatemia	10.3	TG, TPO, TSHR
22	familial abdominal aortic aneurysm	10.3	TG, TPO, TSHR
23	hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia	10.3	SERPINA7, TG, TSHR
24	deafness, autosomal recessive 4, with enlarged vestibular aqueduct	10.3	TG, TPO
25	scabies	10.3	CALCA, TG
26	corneal ectasia	10.2	CALCA, TG
27	rh isoimmunization	10.2	TG, TPO, TSHR
28	chest wall lymphoma	10.2	CALCA, TG
29	thyroid hormone resistance	10.2	SERPINA7, TRH
30	euthyroid sick syndrome	10.2	SERPINA7, TPO, TRH
31	hypoaldosteronism	10.2	CALCA, TG
32	ovarian cyst	10.1	CALCA, TG
33	bone cancer	10.1	CALCA, TG, TPO
34	ovarian endometrioid cystadenoma	10.1	CALCA, TG, TPO
35	pituitary adenoma	10.0	SERPINA7, TRH
36	accommodative spasm	10.0	SERPINA7, TG, TPO, TSHR
37	thyrotoxic exophthalmos	10.0	SERPINA7, TG, TPO, TSHR
38	ulcerative blepharitis	9.9	CALCA, TPO
39	nodular goiter	9.8
40	adenoma	9.8
41	lingual goiter	9.7	CALCA, TG, TPO, TSHR
42	endemic goiter	9.7	CALCA, TG, TPO, TSHR
43	parenchymatous neurosyphilis	9.7	CALCA, TG, TPO, TSHR
44	mediastinal osteogenic sarcoma	9.7	CALCA, TG, TPO, TSHR
45	hashimoto thyroiditis	9.7	CALCA, TG, TPO, TSHR
46	frontotemporal dementia and/or amyotrophic lateral sclerosis 4	9.7	CALCA, TG, TPO, TSHR
47	chorea, hereditary benign	9.7	CALCA, TG, TPO, TSHR
48	adrenal rest tumor	9.7	CALCA, TG, TPO, TSHR
49	hypertelorism, preauricular sinus, punctal pits, and deafness	9.6	SERPINA7, TG, TPO, TRH, TSHR
50	tinea corporis	9.6	SERPINA7, TG, TPO, TRH, TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:

Symptoms for Toxic Diffuse Goiter

Drugs & Therapeutics for Toxic Diffuse Goiter

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶⁵UMLS, ⁴³NDF-RT
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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

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³³MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

³³

Thyroid, Pituitary, Liver, Bone, Lung, Skin, Breast

Animal Models for Toxic Diffuse Goiter or affiliated genes

Sources:
³⁸MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	8.2	ABCA1, TG, TNFRSF25, TPO, TRH, TSHR
2	hematopoietic system	MP:0005397	7.2	ABCA1, F3, PTN, TG, TNFRSF25, TPO

Publications for Toxic Diffuse Goiter

Sources:
⁵⁴PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 24)

id	Title	Authors	Year
1	Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)	Savchenko O.V.... Toupeleev P.A.	2012
2	Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)	Cardoso L.C.... Carvalho D.P.	2002
3	Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)	Hosaka Y.... Hosoya T.	1993
4	Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)	Kamel N.... Polat H.	1988
5	Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)	Ericsson U.B.... Thorell J.I.	1987
6	HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)	Schleusener H.... Wenzel K.W.	1983
7	Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)	Heggi F.N.	1981
8	Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)	Steinbach J.J.... Goldman J.K.	1979
9	The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)	Von Hofe S.E.... Young R.L.	1978
10	The choice of therapy in toxic diffuse goiter. (80165)	Young R.L.... Dorfman S.G.	1978
11	Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)	Nagataki S.... Masuyama Y.	1977
12	Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)	Barnes H.V.... Blizzard R.M.	1977
13	I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)	Yang H.F.	1972
14	I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)	Yang H.F.	1971
15	Treatment of toxic diffuse goiter. (4183010)	Stanbury J.B.	1969
16	I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)	Yang H.F.... Chen C.C.	1969
17	Toxic diffuse goiter in children. (5819609)	Mosier H.D.	1969
18	The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)	BLOOMFIELD A.L.	1957
19	Chronic treatment of toxic diffuse goiter. (13457490)	REVENO W.S.... Rosenbaum H.	1957
20	Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)	SELIGMAN B.	1952
21	Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)	Topper A.	1951
22	Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)	GREENBERG S.U.... BRUGER M.	1950
23	Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)	PRINZMETAL M.... AGRESS C.M.	1949
24	The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)	McKNIGHT R.B.	1946

Genes related to Toxic Diffuse Goiter

Sources:
²⁰GeneCards, ¹²DISEASES, ⁴⁷Novoseek
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Genes related to Toxic Diffuse Goiter:

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	TG	Thyroglobulin	25.11	DISEASES inferred ¹² Novoseek inferred ⁴⁷	1422230, 11873391
2	TPO	Thyroid Peroxidase	18.61	Novoseek inferred ⁴⁷	7951488, 1422230, 11549671 more 11600551, 12213665
3	TDG	Thymine DNA Glycosylase	17.59	DISEASES inferred ¹²
4	SERPINA7	Serpin Family A Member 7	15.10	DISEASES inferred ¹²
5	TSHR	Thyroid Stimulating Hormone Receptor	14.83	Novoseek inferred ⁴⁷	1658772
6	TRH	Thyrotropin Releasing Hormone	14.41	DISEASES inferred ¹²
7	ABCA1	ATP Binding Cassette Subfamily A Member 1	14.37	DISEASES inferred ¹²
8	TNFRSF25	Tumor Necrosis Factor Receptor Superfamily Member 25	14.19	DISEASES inferred ¹²
9	CALCA	Calcitonin Related Polypeptide Alpha	13.52	DISEASES inferred ¹²
10	F3	Coagulation Factor III, Tissue Factor	13.47	DISEASES inferred ¹²
11	PTN	Pleiotrophin	5.22	DISEASES inferred ¹²

Variations for Toxic Diffuse Goiter

Expression for genes affiliated with Toxic Diffuse Goiter

Sources:
¹⁷Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

Sources:
⁵²PathCards, ³¹KEGG, ⁵⁷Reactome, ³⁹NCBI BioSystems Database
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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Insulin secretion³¹ Show member pathways Thyroid hormone synthesis³¹ Aldosterone synthesis and secretion³¹ Ca2+ activated K+ channels⁵⁷	9.5	TG, TPO, TSHR
2	Thyroxine (Thyroid Hormone) Production³⁹	9.1	TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

Sources:
¹⁸Gene Ontology
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Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:0042446	10.0	TG, TPO
2	thyroid hormone generation	GO:0006590	9.8	TG, TPO
3	response to low-density lipoprotein particle	GO:0055098	9.6	ABCA1, F3
4	positive regulation of cAMP biosynthetic process	GO:0030819	9.4	ABCA1, CALCA
5	activation of adenylate cyclase activity	GO:0007190	9.2	CALCA, TSHR

Sources for Toxic Diffuse Goiter

¹BitterDB

²CDC

³Cell Signaling Technology

⁴ClinicalTrials

⁵Clinvar

⁶Cochrane Library

⁷Cosmic

⁸dbSNP

⁹DGIdb

¹⁰Disease Ontology

¹¹diseasecard

¹²DISEASES

¹³DrugBank

¹⁴ExPASy

¹⁵FDA

¹⁶FMA

¹⁷Gene Expression Omnibus DataSets

¹⁸Gene Ontology

¹⁹GeneAnalytics

²⁰GeneCards

²¹GeneReviews

²²GeneTests

²³Genetics Home Reference

²⁴GTR

²⁵HGMD

²⁶HMDB

²⁷ICD10

²⁸ICD10 via Orphanet

²⁹ICD9CM

³⁰IUPHAR

³¹KEGG

³²LifeMap Discovery®

³³MalaCards

³⁴MedGen

³⁵MedlinePlus

³⁶MeSH

³⁷MESH via Orphanet

³⁸MGI

³⁹NCBI BioSystems Database

⁴⁰NCBI Bookshelf

⁴¹NCI

⁴²NCIt

⁴³NDF-RT

⁴⁴NIH Clinical Center

⁴⁵NIH Rare Diseases

⁴⁶NINDS

⁴⁷Novoseek

⁴⁸Novus Biologicals

⁴⁹OMIM

⁵⁰OMIM via Orphanet

⁵¹Orphanet

⁵²PathCards

⁵³PharmGKB

⁵⁴PubMed

⁵⁵QIAGEN

⁵⁶R&D Systems

⁵⁷Reactome

⁵⁸SinoBiological

⁵⁹SNOMED-CT

⁶⁰SNOMED-CT via Orphanet

⁶¹The Human Phenotype Ontology

⁶²Thomson Reuters

⁶³Tocris Bioscience

⁶⁴Tumor Gene Family of Databases

⁶⁵UMLS

⁶⁶UMLS via Orphanet

⁶⁷UniProtKB/Swiss-Prot

⁶⁸Wikipedia

MCID: TXC004 MIFTS: 29	Toxic Diffuse Goiter malady Category: Endocrine diseases
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Toxic Diffuse Goiter malady