MCID: TXC004
MIFTS: 21

Toxic Diffuse Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 11 13 48 66

Classifications:



External Ids:

Disease Ontology11 DOID:10719
ICD9CM30 242.00

Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to nodular goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TDG (Thymine DNA Glycosylase), and among its related pathways is Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid and whole blood.

Related Diseases for Toxic Diffuse Goiter

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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1nodular goiter29.3CALCA, SERPINA7, TG
2graves' disease11.9
3goiter10.5
4peripheral scars of retina10.5C6orf15, TG
5tinea corporis10.4SERPINA7, TG
6hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.4SERPINA7, TG
7presbyopia10.4SERPINA7, TG
8papilledema10.4TG, TRH
9lung occult adenocarcinoma10.4SERPINA7, TG
10hemoglobin c disease10.3SERPINA7, TRH
11cardiovascular organ benign neoplasm10.3TG, TRH
12thyroid hormone resistance10.3SERPINA7, TRH
13craniopharyngioma10.2SERPINA7, TRH
14deep angioma10.1CALCA, TG
15acute thyroiditis10.1CALCA, TG
16pleomorphic adenoma10.1CALCA, TG
17mixed endometrial stromal and smooth muscle tumor10.0CALCA, TG
18hypertelorism, preauricular sinus, punctal pits, and deafness10.0SERPINA7, TG, TRH
19norwegian scabies10.0CALCA, TG
20hypocomplementemic urticarial vasculitis syndrome10.0CALCA, TG
21atheroembolism of kidney10.0SERPINA7, TG, TRH
22bone lymphoma10.0CALCA, TG
23thyroiditis10.0
24substernal goiter10.0CALCA, TG
25epididymal neoplasm10.0CALCA, TG
26meningovascular neurosyphilis9.9CALCA, TG
27malignant mediastinum hemangiopericytoma9.9CALCA, TG
28cd3zeta deficiency9.9SERPINA7, TG, TNFRSF25
29hereditary conventional renal cell carcinoma9.9CALCA, TG
30kidney benign neoplasm9.8CALCA, TG
31hypothyroidism9.8
32adenoma9.8
33dysgraphia9.8CALCA, TG
34richter's syndrome9.8CALCA, TG
35lipoma of the rectum9.7CALCA, TG
36medullary thyroid carcinoma, familial9.7CALCA, TG
37nodular prostate9.7CALCA, SERPINA7, TG
38hashimoto thyroiditis9.6CALCA, TG
39blood group incompatibility9.6TG, TNFRSF25
40central nervous system hemangioma9.3CALCA, SERPINA7, TG, TRH
41lung occult large cell carcinoma9.3CALCA, SERPINA7, TG, TRH
42echinostomiasis9.3CALCA, SERPINA7, TG, TRH
43alveoli adenoma9.2CALCA, SERPINA7, TG, TRH
44cerebral lipidosis7.0ABCA1, C6orf15, CALCA, PTN, SERPINA7, TDG

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Antithyroid Drugs During Radioiodine TherapyCompletedNCT00150137Phase 4
2Block-replacement Therapy During Radioiodine TherapyCompletedNCT00150124Phase 4

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

34
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7TG, TRH

GO Terms for genes affiliated with Toxic Diffuse Goiter

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Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.3CALCA, PTN, SERPINA7, TG, TNFRSF25, TRH

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan bindingGO:00055399.6C6orf15, PTN

Sources for Toxic Diffuse Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet