MCID: TXC004
MIFTS: 22

Toxic Diffuse Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 10 47 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:10719
ICD9CM29 242.00
UMLS65 C0154138, C0342122

Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to graves' disease and autoimmune thyroiditis. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Related Diseases for Toxic Diffuse Goiter

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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease12.1
2autoimmune thyroiditis10.4TG, TPO
3thyroid ectopia10.4TG, TPO
4neonatal meningitis10.4TG, TPO
5rhabdomyosarcoma, embryonal, 210.4TG, TPO
6solar retinopathy10.4TG, TPO
7goiter10.3SERPINA7, TG
8chronic inflammatory demyelinating polyradiculoneuropathy10.3TG, TSHR
9iatrogenic or traumatic pituitary deficiency10.3TG, TSHR
10setariasis10.3TG, TPO
11riedel's fibrosing thyroiditis10.3TG, TRH
12hypothyroidism10.3TG, TRH
13perivascular epithelioid cell tumor10.3TG, TSHR
14hypothryoidism, congenital, nongoitrous 410.3TG, TPO
15megaloblastic anemia10.3TG, TPO
16laryngeal mucoepidermoid carcinoma10.2CALCA, TG
17fuchs' heterochromic uveitis10.2TG, TSHR
18glaucoma, primary open angle, juvenile-onset, 210.2TG, TPO
19skin angiosarcoma10.2CALCA, TG
20thyroiditis10.2TG, TPO, TSHR
21hypophosphatemia10.2TG, TPO, TSHR
22familial abdominal aortic aneurysm10.2TG, TPO, TSHR
23hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.2SERPINA7, TG, TSHR
24deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.2TG, TPO
25scabies10.2CALCA, TG
26corneal ectasia10.2CALCA, TG
27rh isoimmunization10.2TG, TPO, TSHR
28chest wall lymphoma10.1CALCA, TG
29thyroid hormone resistance10.1SERPINA7, TRH
30euthyroid sick syndrome10.1SERPINA7, TPO, TRH
31hypoaldosteronism10.1CALCA, TG
32ovarian cyst10.1CALCA, TG
33bone cancer10.0CALCA, TG, TPO
34rheumatoid arthritis10.0
35atopy10.0
36breast cancer10.0
37esophageal cancer10.0
38alzheimer disease10.0
39lipoma10.0
40arthritis10.0
41cataract10.0
42charcot-marie-tooth disease10.0
43restless legs syndrome10.0
44hyperphosphatemia10.0
45anosognosia10.0
46tooth disease10.0
47neonatal respiratory failure10.0
48respiratory failure10.0
49subdural empyema10.0
50diphtheria10.0

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

33
Liver

Animal Models for Toxic Diffuse Goiter or affiliated genes

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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2ABCA1, TG, TNFRSF25, TPO, TRH, TSHR
2MP:00053977.2ABCA1, F3, PTN, TG, TNFRSF25, TPO

Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Intranetwork and internetwork functional connectivity abnormalities in pediatric multiple sclerosis. (24510680)
2014
2
Transcranial color-coded Doppler assessment of cerebral arteriovenous malformation hemodynamics in patients treated surgically or with staged embolization. (24309152)
2014
3
Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond. (25301689)
2014
4
The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease. (23889991)
2013
5
Climate change and West Nile virus in a highly endemic region of North America. (23880729)
2013
6
Hereditary hyperferritinemia cataract syndrome in four patients with mutations in the IRE of the FTL gene. (22881709)
2013
7
Sodium arsenite A+ hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. (22331493)
2012
8
Interleukin-1I^ causes synaptic hyperexcitability in multiple sclerosis. (22275254)
2012
9
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. (22267120)
2012
10
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. (20081843)
2010
11
GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus. (20167840)
2010
12
Minimally invasive therapy of cervical intraepithelial neoplasia for fertility preservation. (19148775)
2009
13
What is "high risk?" a systematic review of atopy risk and implications for primary prevention. (19706083)
2009
14
An autopsy case of chronic active Epstein-Barr virus infection (CAEBV): distribution of central nervous system (CNS) lesions. (18793782)
2008
15
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. (17562860)
2007
16
Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients. (16620355)
2006
17
Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. (16100117)
2005
18
Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population. (14741193)
2004
19
Nutrition and infectious diseases in developing countries and problems of acquired immunodeficiency syndrome. (15169964)
2004
20
Amino acid substitution within the S2 and S4 transmembrane segments in Shaker potassium channel modulates channel gating. (10973789)
2000
21
Participation of a cathepsin L-type protease in the activation of caspase-3. (10698261)
1999
22
Effects of interleukin-1 beta on matrix metalloproteinase-3 levels in human periodontal ligament cells. (9203094)
1997
23
Nitric oxide synthase expression in human neuroblastoma cell line induced by cytokines. (8724659)
1996
24
Expression of aminopeptidase N/CD13 in tumour-infiltrating lymphocytes from human renal cell carcinoma. (7829125)
1994

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5TG, TPO, TSHR
29.1TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

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Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.0TG, TPO
2thyroid hormone generationGO:00065909.8TG, TPO
3response to low-density lipoprotein particleGO:00550989.6ABCA1, F3
4positive regulation of cAMP biosynthetic processGO:00308199.4ABCA1, CALCA
5activation of adenylate cyclase activityGO:00071909.2CALCA, TSHR

Sources for Toxic Diffuse Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet