MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter malady

Endocrine diseases category

Aliases & Classifications for Toxic Diffuse Goiter

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 29ICD9CM
See all sources

Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 10 47 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:10719
ICD9CM29 242.00

Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to thyroiditis and nodular goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are hearing/vestibular/ear and growth/size/body.

Related Diseases for Toxic Diffuse Goiter

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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.8CALCA, TG
2nodular goiter30.2CALCA, TG, TPO, TSHR
3goiter10.9
4graves' disease10.6
5autoimmune thyroiditis10.3TG, TPO
6rhabdomyosarcoma, embryonal, 210.3TG, TPO
7thyroid ectopia10.3TG, TPO
8adult central nervous system germinoma10.2TG, TSHR
9iatrogenic or traumatic pituitary deficiency10.2TG, TSHR
10lumbosacral plexus lesion10.2TG, TPO
11methemoglobinemia10.2TG, TPO
12radial nerve lesion10.2SERPINA7, TG
13subcutaneous mycosis10.2TG, TSHR
14atrophy of prostate10.2TG, TRH
15hypothryoidism, congenital, nongoitrous 410.2TG, TPO
16dyshormonogenic goiter10.2TG, TRH
17adenoma10.2
18hypothyroidism10.2
19neurofibrosarcoma10.2TG, TPO
20glaucoma, primary open angle, juvenile-onset, 210.2TG, TPO
21appendiceal neoplasm10.2TRH, TSHR
22gonococcal iridocyclitis10.2TG, TSHR
23neonatal meningitis10.2TG, TPO, TSHR
24intraneural perineurioma10.1CALCA, TG
25familial abdominal aortic aneurysm10.1TG, TPO, TSHR
26hypophosphatemia10.1TG, TPO, TSHR
27selective iga deficiency disease10.1CALCA, TG
28thyroid hormone resistance10.1SERPINA7, TRH
29riedel's fibrosing thyroiditis10.1CALCA, TG
30hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1SERPINA7, TG, TSHR
31uterine corpus adenofibroma10.1CALCA, TG
32pendred syndrome10.1TG, TPO
33hypoaldosteronism10.1CALCA, TG
34hypersensitivity reaction type iii disease10.1TG, TPO, TSHR
35colon lymphoma10.1SERPINA7, TPO, TRH
36vulvar apocrine adenocarcinoma10.1CALCA, TG
37endocrine pancreas disease10.1TG, TRH
38posterior cerebral artery infarction10.1SERPINA7, TRH
39pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.0CALCA, TPO
40mononeuritis of upper limb10.0CALCA, TG, TPO
41subleukemic leukemia10.0SERPINA7, TG, TPO, TSHR
42hereditary night blindness10.0SERPINA7, TG, TPO, TSHR
43macular holes10.0CALCA, TSHR
44endocrine organ benign neoplasm10.0CALCA, TG, TSHR
45xeroderma pigmentosum, group c10.0ABCA1, TDG
46pseudopterygium10.0SERPINA7, TG, TPO, TSHR
47autoimmune disease of gastrointestinal tract9.9TG, TNFRSF25, TPO, TSHR
48lingual goiter9.9CALCA, TG, TPO, TSHR
49eumycotic mycetoma9.9CALCA, TG, TPO, TSHR
50food allergy9.9CALCA, TG, TPO, TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

33
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0CALCA, PTN, TPO, TSHR
2MP:00053787.6ABCA1, F3, TDG, TG, TPO, TRH
3MP:00053977.2ABCA1, F3, PTN, TG, TNFRSF25, TPO
4MP:00036316.6ABCA1, CALCA, F3, PTN, TDG, TG
5MP:00053766.1ABCA1, CALCA, F3, PTN, TDG, TG

Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TG, TPO, TSHR
29.1TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

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Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.6CALCA, F3, PTN, SERPINA7, TG, TPO
2extracellular regionGO:00055767.4CALCA, PTN, SERPINA7, TG, TNFRSF25, TRH

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated signaling pathwayGO:000975510.1TRH, TSHR
2response to corticosteroneGO:005141210.0SERPINA7, TRH
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.9CALCA, TSHR
4activation of adenylate cyclase activityGO:00071909.9CALCA, TSHR
5response to low-density lipoprotein particleGO:00550989.8ABCA1, F3
6positive regulation of cAMP biosynthetic processGO:00308199.7ABCA1, CALCA
7hormone biosynthetic processGO:00424469.6TG, TPO
8cell-cell signalingGO:00072679.3CALCA, TRH, TSHR
9response to lipopolysaccharideGO:00324968.9F3, TG, TNFRSF25
10agingGO:00075688.7CALCA, F3, SERPINA7

Sources for Toxic Diffuse Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet