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MCID: TXC004
MIFTS: 28

Toxic Diffuse Goiter malady
4 genes, 2 tissues, 37 related diseases, clinical trials.

Summaries for Toxic Diffuse Goiter

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33MalaCards
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MalaCards: Toxic Diffuse Goiter is related to graves' disease and thyrotoxicosis. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The compounds chromium and carbimazole have been mentioned in the context of this disorder. Affiliated tissues include whole blood and thyroid, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Classifications for Toxic Diffuse Goiter

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8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM
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Aliases & Descriptions:

toxic diffuse goiter 8 10 45 61


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Disease Ontology8 DOID:10719
ICD9CM27 242.00

Related Diseases for Toxic Diffuse Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease30.8TPO, TG, TSHR
2thyrotoxicosis30.5TG, TPO, TSHR
3nodular goiter30.2TSHR, TPO, TG
4adenoma30.2TG, TSHR, TPO
5subacute thyroiditis10.0TG
6hyperthyroxinemia10.0TSHR, TPO
7viral hepatitis10.0TSHR
8pernicious anemia10.0TG, TPO
9plummer's disease10.0TG, TPO
10thyrotropin deficiency, isolated10.0TPO, TG
11autoimmune thyroiditis10.0TG, TPO
12pendred syndrome10.0TPO, TG
13down syndrome10.0TSHR, TPO
14thyroid agenesis10.0TSHR, TG
15struma ovarii10.0TG, TSHR
16celiac disease10.0TPO, TG
17turner syndrome10.0TPO, TG
18follicular thyroid carcinoma10.0TSHR, TG
19pregnancy loss10.0TG, TPO
20addison's disease10.0TG, TPO
21nontoxic goiter10.0TPO, TG, TSHR
22endemic goiter10.0TSHR, TPO, TG
23myxedema10.0TPO, TSHR, TG
24goiter10.0TSHR, TG, TPO
25multinodular goiter10.0TPO, TG, TSHR
26thyroid cancer, anaplastic10.0TG, TPO, TSHR
27follicular adenoma10.0TPO, TSHR, TG
28congenital hypothyroidism10.0TPO, TG, TSHR
29thyroid adenoma10.0TPO, TSHR, TG
30papillary carcinoma10.0TG, TPO, TSHR
31papillary thyroid carcinoma10.0TG, TPO, TSHR
32type 1 diabetes10.0TPO, TG, TSHR
33hyperthyroidism10.0TPO, TG, TSHR
34hypothyroidism10.0TG, TPO, TSHR
35hypersensitivity reaction type ii disease10.0TG, TPO, TSHR
36thyroid cancer10.0TPO, TG, TSHR
37thyroiditis10.0TSHR, TPO, TG

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Clinical Features for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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33MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

33
Whole blood, Thyroid

Animal Models for Toxic Diffuse Goiter or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
homeostasis/metabolism phenotype
MP:00053768.0TG, TPO, TDG, TSHR
2
growth/size phenotype
MP:00053787.7TG, TPO, TDG, TSHR

Publications for Toxic Diffuse Goiter

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51PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 31)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
The predictive role of 24h RAIU with respect to the outcome of low fixed dose radioiodine therapy in patients with diffuse toxic goiter. (23422768)
2012
3
Correlation between serum leptin levels and insulin sensitivity in diffuse toxic goiter. (15098916)
2004
4
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
5
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
6
Osteocalcin in diffuse toxic goiter]. (1377070)
1992
7
Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter]. (1658772)
1991
8
The presence of antithyroid antibodies in the blood serum of patients with diffuse toxic goiter before and during treatment]. (2080137)
1990
9
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
10
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
11
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
12
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
13
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
14
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
15
The choice of therapy in toxic diffuse goiter. (80165)
1978
16
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
17
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
18
Functional state of the stomach in patients with diffuse toxic goiter and hypothyroidism]. (1173954)
1975
19
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
20
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
21
Treatment of toxic diffuse goiter. (4183010)
1969
22
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
23
Toxic diffuse goiter in children. (5819609)
1969
24
Induction of myxedema by iodide in patients euthyroid after radioiodin or surgical treatment of diffuse toxic goiter. (4980221)
1969
25
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
26
Chronic treatment of toxic diffuse goiter. (13457490)
1957
27
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
28
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
29
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
30
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
31
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Genetic Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

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Pathways for genes affiliated with Toxic Diffuse Goiter

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30KEGG
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Pathways related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Insulin secretion30
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9.1TG, TPO
2
Allograft rejection30
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8.5TG, TPO, TSHR

Compounds for genes affiliated with Toxic Diffuse Goiter

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45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1chromium4510.3TPO
2carbimazole45 1110.7TPO, TSHR
3amino acid459.7TSHR, TPO
4maltose45 1110.7TSHR, TPO
5asparagine459.6TPO, TSHR
6cytosine45 2410.6TDG, TSHR
7iodotyrosine45 2410.5TG, TPO
8diiodotyrosine459.5TPO, TG
9perchlorate459.5TG, TPO
10gliadin459.5TG, TPO
11amiodarone45 50 29 1112.5TG, TPO
12cardiolipin45 1110.5TPO, TG
13selenium45 2410.4TG, TPO
14adenine45 11 2411.4TDG, TSHR
15sodium dodecylsulfate459.4TG, TPO
16hydrocortisone45 2 60 1112.4TG, TPO
17gold459.3TG, TPO
18prednisolone45 29 1111.3TSHR, TG
19sialic acid459.2TSHR, TG
20agarose459.0TSHR, TPO
21mannose459.0TG, TSHR
22sodium iodide458.9TG, TPO, TSHR
23propylthiouracil45 2 1110.9TG, TPO, TSHR
24iodine45 249.9TSHR, TPO, TG
25carbohydrates458.9TSHR, TG
26125i458.9TG, TPO, TSHR
27iodide45 249.9TSHR, TPO, TG
28methimazole45 2 1110.9TG, TPO, TSHR
29triiodothyronine458.9TG, TPO, TSHR
30thyroxine45 249.9TSHR, TPO, TG
31guanine45 11 2410.9TSHR, TDG, TG
32ribonucleic acid458.9TG, TPO, TSHR
33polysaccharide458.9TG, TPO, TSHR
34sodium45 249.8TG, TPO, TSHR
35aspartate458.8TSHR, TPO, TG
36adenylate458.8TG, TPO, TSHR
37arginine458.8TSHR, TPO, TG
38glutamate458.8TSHR, TPO, TG
39estrogen458.7TG, TDG, TSHR
40retinoic acid45 249.6TSHR, TPO, TG
41cysteine458.5TG, TPO, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

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16Gene Ontology
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Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TG, TPO
2hormone biosynthetic processGO:0424468.8TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Diffuse Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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