MCID: TXC004
MIFTS: 33

Toxic Diffuse Goiter malady

Endocrine diseases category
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Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Allograft rejection and Insulin secretion. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are endocrine/exocrine gland and growth/size/body.

Aliases & Classifications for Toxic Diffuse Goiter

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM
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Toxic Diffuse Goiter, Aliases & Descriptions:

Name: Toxic Diffuse Goiter 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:10719
ICD9CM27 242.00

Related Diseases for Toxic Diffuse Goiter

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Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Drug clinical trials:

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Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

32
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5TSHR, TG, TPO
2MP:00053787.9TDG, TSHR, TG, TPO
3MP:00053767.7TPO, TG, TSHR, TDG

Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

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Pathways for genes affiliated with Toxic Diffuse Goiter

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Compounds for genes affiliated with Toxic Diffuse Goiter

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Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1carbimazole44 1110.7TSHR, TPO
2amino acid449.7TPO, TSHR
3maltose44 1110.7TPO, TSHR
4asparagine449.7TPO, TSHR
5cytosine44 2410.7TDG, TSHR
6iodotyrosine44 2410.6TG, TPO
7diiodotyrosine449.6TG, TPO
8perchlorate449.5TG, TPO
9adenine44 24 1111.5TSHR, TDG
10gliadin449.5TG, TPO
11chromium449.5TPO, TG
12amiodarone44 50 28 1112.5TG, TPO
13cardiolipin44 1110.5TG, TPO
14selenium44 2410.5TPO, TG
15agarose449.5TSHR, TPO
16sodium dodecylsulfate449.4TG, TPO
17acth449.4TSHR, TPO
18hydrocortisone44 2 61 1112.4TG, TPO
19gold449.4TG, TPO
20prednisolone44 28 1111.3TSHR, TG
21sialic acid449.3TSHR, TG
22histidine449.2TPO, TSHR
23carbohydrates449.2TSHR, TG
24mannose449.1TG, TSHR
25ascorbic acid44 2410.1TG, TPO
2612-o-tetradecanoylphorbol 13-acetate449.0TPO, TSHR
27sodium iodide449.0TSHR, TG, TPO
28propylthiouracil44 2 1111.0TSHR, TG, TPO
29iodine44 249.9TPO, TG, TSHR
30125i448.9TSHR, TG, TPO
31iodide44 249.9TPO, TG, TSHR
32methimazole44 2 1110.9TSHR, TG, TPO
33triiodothyronine448.9TPO, TG, TSHR
34thyroxine44 249.9TPO, TG, TSHR
35guanine44 24 1110.9TG, TSHR, TDG
36ribonucleic acid448.9TSHR, TG, TPO
37polysaccharide448.9TSHR, TG, TPO
38sodium44 249.9TSHR, TG, TPO
39aspartate448.9TPO, TG, TSHR
40adenylate448.9TSHR, TG, TPO
41arginine448.9TSHR, TG, TPO
42glutamate448.8TSHR, TG, TPO
43estrogen448.8TG, TSHR, TDG
44retinoic acid44 249.8TSHR, TG, TPO
45cysteine448.8TPO, TG, TSHR
46tyrosine448.5TSHR, TG, TPO

GO Terms for genes affiliated with Toxic Diffuse Goiter

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Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TG, TPO
2hormone biosynthetic processGO:0424468.8TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

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Sources for Toxic Diffuse Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet