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MCID: TXC004

Toxic Diffuse Goiter malady
4 genes, 1 tissue, 37 related diseases, clinical trials.

Summaries for Toxic Diffuse Goiter

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29MalaCards
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MalaCards: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways is Allograft rejection. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and thyroid, and related mouse phenotype growth/size.

Aliases & Classifications for Toxic Diffuse Goiter

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8Disease Ontology, 10DISEASES, 41Novoseek, 56UMLS, 25ICD9CM
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Aliases & Descriptions:

toxic diffuse goiter 8 10 41 56



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Disease Ontology8 DOID:10719
ICD9CM25 242.00

Related Diseases for Toxic Diffuse Goiter

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16GeneCards, 17GeneDecks
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Diseases related to toxic diffuse goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1goiter30.3TSHR, TPO, TG
2graves' disease30.0TG, TPO, TSHR
3thyroiditis28.1TPO, TSHR, TG
4subacute thyroiditis12.9TG
5hyperthyroxinemia12.6TSHR, TPO
6megaloblastic anemia12.5TPO, TG
7plummer's disease12.5TG, TPO
8thyrotropin deficiency, isolated12.5TPO, TG
9autoimmune thyroiditis12.4TG, TPO
10thyrotoxicosis12.4TG, TSHR
11pendred syndrome12.4TPO, TG
12struma ovarii12.4TSHR, TG
13thyroid agenesis12.4TG, TSHR
14down syndrome12.3TPO, TSHR
15turner syndrome12.3TPO, TG
16follicular thyroid carcinoma12.3TSHR, TG
17celiac disease12.3TPO, TG
18sycp3-related pregnancy loss, susceptibility to12.3TPO, TG
19addison's disease12.1TPO, TG
20nontoxic goiter12.0TG, TSHR, TPO
21endemic goiter11.9TG, TPO, TSHR
22myxedema11.9TSHR, TPO, TG
23nodular goiter11.9TG, TSHR, TPO
24thyroid cancer11.9TSHR, TG, TPO
25multinodular goiter11.9TG, TSHR, TPO
26thyroid cancer, anaplastic11.9TPO, TSHR, TG
27thyroid medullary carcinoma11.9TPO, TG, TSHR
28follicular adenoma11.9TPO, TG, TSHR
29congenital hypothyroidism11.9TPO, TSHR, TG
30thyroid adenoma11.9TSHR, TPO, TG
31nonencapsulated sclerosing carcinoma11.9TPO, TG, TSHR
32papillary thyroid carcinoma11.9TPO, TSHR, TG
33type 1 diabetes mellitus11.8TPO, TSHR, TG
34hyperthyroidism11.8TG, TSHR, TPO
35hypothyroidism11.8TPO, TSHR, TG
36hypersensitivity reaction type ii disease11.6TSHR, TG, TPO
37malignant thyroid stimulating hormone producing neoplasm of pituitary gland11.2TG, TPO, TSHR

Graphical network of the top 20 diseases related to toxic diffuse goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for toxic diffuse goiter

Drug clinical trials:

Search ClinicalTrials for toxic diffuse goiter

Search NIH Clinical Center for toxic diffuse goiter

Search CenterWatch for toxic diffuse goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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29MalaCards
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MalaCards organs/tissues related to toxic diffuse goiter:

29
Thyroid

Animal Models for Toxic Diffuse Goiter or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to toxic diffuse goiter:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
growth/size phenotype
MP:00053788.0TPO, TSHR, TG, TDG

Publications for Toxic Diffuse Goiter

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47PubMed
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Articles related to toxic diffuse goiter:

idTitleAuthorsYearAffiliating Genes
1Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)Cardoso L.C.... Carvalho D.P.2002TPO
2Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)Hosaka Y.... Hosoya T.1993TPO

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

Pathways for genes affiliated with Toxic Diffuse Goiter

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27KEGG
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Pathways related to toxic diffuse goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Allograft rejection27
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8.5TPO, TSHR, TG

Compounds for genes affiliated with Toxic Diffuse Goiter

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Sources:
41Novoseek, 11DrugBank, 22HMDB, 46PharmGKB, 2BitterDB
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Compounds related to toxic diffuse goiter according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1carbimazole41 1110.7TPO, TSHR
2amino acid419.7TSHR, TPO
3maltose41 1110.7TPO, TSHR
4asparagine419.6TPO, TSHR
5cytosine41 2210.6TSHR, TDG
6iodotyrosine41 2210.5TPO, TG
7diiodotyrosine419.5TPO, TG
8perchlorate419.5TPO, TG
9gliadin419.5TG, TPO
10chromium419.5TPO, TG
11amiodarone41 46 1111.5TPO, TG
12cardiolipin41 1110.5TPO, TG
13selenium41 2210.4TG, TPO
14sodium dodecylsulfate419.4TPO, TG
15adenine41 11 2211.3TSHR, TDG
16hydrocortisone41 2 1111.3TPO, TG
17gold419.2TG, TPO
18agarose419.2TSHR, TPO
19prednisolone41 1110.2TSHR, TG
20sialic acid419.1TSHR, TG
21sodium iodide418.9TPO, TSHR, TG
22propylthiouracil41 2 1110.9TG, TSHR, TPO
23iodine41 229.9TPO, TSHR, TG
24125i418.9TG, TSHR, TPO
25iodide41 229.9TPO, TSHR, TG
26methimazole41 2 1110.9TG, TSHR, TPO
27triiodothyronine418.9TG, TSHR, TPO
28thyroxine41 229.9TG, TSHR, TPO
29guanine41 11 2210.9TSHR, TG, TDG
30ribonucleic acid418.9TPO, TSHR, TG
31polysaccharide418.8TG, TSHR, TPO
32sodium41 229.8TPO, TSHR, TG
33aspartate418.8TG, TSHR, TPO
34adenylate418.8TPO, TSHR, TG
35arginine418.8TG, TSHR, TPO
36carbohydrates418.7TG, TSHR
37glutamate418.7TG, TSHR, TPO
38estrogen418.5TSHR, TG, TDG

GO Terms for genes affiliated with Toxic Diffuse Goiter

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15Gene Ontology
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Biological processes related to toxic diffuse goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TPO, TG
2hormone biosynthetic processGO:0424468.8TPO, TG

Products for genes affiliated with Toxic Diffuse Goiter

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  • Antibodies
  • Proteins
  • Lysates

Sources for Toxic Diffuse Goiter

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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