MCID: TXC004
MIFTS: 28

Toxic Diffuse Goiter malady

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 35 242.00
UMLS 69 C0154138

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Insulin secretion and Amine-derived hormones. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related phenotype is endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 graves' disease 11.9
2 goiter 10.4
3 fibrous meningioma 10.3 TG TPO
4 premature closure of the arterial duct 10.3 TG TPO
5 acute hemorrhagic encephalitis 10.3 TG TSHR
6 tick paralysis 10.3 TG TPO
7 mesocardia 10.3 TG TSHR
8 atheroembolism of kidney 10.3 TG TRH
9 parachordoma 10.2 TG TSHR
10 echinostomiasis 10.2 SERPINA7 TG
11 frontal sinusitis 10.2 TG TPO
12 caudal regression syndrome 10.2 TG TPO
13 color blindness 10.2 TG TPO
14 neuhauser daly magnelli syndrome 10.2 TG TPO TSHR
15 conjunctival deposit 10.2 TG TPO TSHR
16 denys-drash syndrome 10.2 TG TPO TSHR
17 commensal bacterial infectious disease 10.2 TG TPO TSHR
18 choreoathetosis, hypothyroidism, and neonatal respiratory distress 10.2 TG TPO TSHR
19 non-distal monosomy 10q 10.2 TG TPO TSHR
20 extrahepatic bile duct adenocarcinoma 10.2 SERPINA7 TG TPO
21 endophthalmitis 10.2 CALCA TG
22 neuronopathy, distal hereditary motor, type viia 10.2 SERPINA7 TG TSHR
23 articulation disorder 10.2 TG TPO TSHR
24 corneal ectasia 10.1 CALCA TG
25 superior vena cava angiosarcoma 10.1 CALCA TG
26 congenital nonspherocytic hemolytic anemia 10.1 SERPINA7 TPO TRH
27 acute laryngitis 10.1 TG TSHR
28 perineural angioma 10.1 CALCA TG
29 parietal lobe neoplasm 10.1 CALCA TG
30 glucosephosphate dehydrogenase deficiency 10.1 DIO2 SERPINA7
31 hypogonadism cardiomyopathy 10.1 CALCA TG
32 thyroid hormone resistance, autosomal recessive 10.1 SERPINA7 TRH
33 rheumatic fever 10.1 TNFRSF10B TNFRSF25
34 background diabetic retinopathy 10.1 SERPINA7 TG TPO TSHR
35 mixed eosinophil-basophil adenoma 10.1 SERPINA7 TG TPO TSHR
36 gastrinoma 10.1 CALCA TG TSHR
37 dysautonomia, familial 10.0 TG TPO
38 childhood vagina botryoid rhabdomyosarcoma 10.0 CALCA TG
39 cowden syndrome 3 10.0 CALCA TG
40 nodular prostate 10.0 CALCA TG TPO TSHR
41 exanthema subitum 10.0 CALCA TG TPO TSHR
42 peritoneal serous papillary adenocarcinoma 10.0 CALCA TG TPO TSHR
43 tenosynovitis of foot and ankle 10.0 CALCA TG TPO TSHR
44 diabetes mellitus, insulin-dependent, 12 9.9 CALCA TG TPO TSHR
45 peritoneal mesothelioma 9.9 CALCA TG TPO TSHR
46 hypothyroidism, congenital, nongoitrous, 1 9.9 SERPINA7 TG TPO TRH TSHR
47 glomangiomyoma 9.9 SERPINA7 TG TPO TRH TSHR
48 cholesterol embolism 9.9 SERPINA7 TG TPO TRH TSHR
49 janus kinase-3 deficiency 9.9 SERPINA7 TG TNFRSF25 TPO TSHR
50 thyroiditis 9.9

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 ABCA1 DIO2 TG TNFRSF25 TPO TRH

Drugs & Therapeutics for Toxic Diffuse Goiter

Drugs for Toxic Diffuse Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 4
2 Hormones Phase 4
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
4 Antithyroid Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

39
Thyroid, Whole Blood

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show all 24)
id Title Authors Year
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. ( 21660794 )
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. ( 12213665 )
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. ( 7951488 )
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. ( 3413443 )
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. ( 2445808 )
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. ( 6131902 )
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 6162933 )
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 94089 )
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. ( 627898 )
1978
10
The choice of therapy in toxic diffuse goiter. ( 80165 )
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. ( 576614 )
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. ( 69022 )
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. ( 4665962 )
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. ( 5281463 )
1971
15
Toxic diffuse goiter in children. ( 5819609 )
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. ( 5257435 )
1969
17
Treatment of toxic diffuse goiter. ( 4183010 )
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). ( 13457495 )
1957
19
Chronic treatment of toxic diffuse goiter. ( 13457490 )
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. ( 14929372 )
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. ( 14810187 )
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. ( 14771065 )
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. ( 18146931 )
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. ( 21002593 )
1946

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.65 SERPINA7 TG TPO TSHR
2
Show member pathways
10.76 DIO2 TPO
3 9.7 TG TPO TRH TSHR

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 C6orf15 CALCA PTN SERPINA7 TG TNFRSF25
2 cell surface GO:0009986 9.02 ABCA1 PTN TNFRSF10B TPO TSHR

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.43 CALCA TSHR
2 activation of adenylate cyclase activity GO:0007190 9.4 CALCA TSHR
3 hormone-mediated signaling pathway GO:0009755 9.37 TRH TSHR
4 thyroid hormone generation GO:0006590 9.32 DIO2 TPO
5 positive regulation of adenylate cyclase activity GO:0045762 9.26 CALCA TSHR
6 thyroid hormone metabolic process GO:0042403 9.16 DIO2 TG
7 positive regulation of cAMP biosynthetic process GO:0030819 9.13 ABCA1 CALCA TSHR
8 hormone biosynthetic process GO:0042446 8.8 DIO2 TG TPO

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.43 TNFRSF10B TNFRSF25 TSHR
2 glycosaminoglycan binding GO:0005539 9.16 C6orf15 PTN
3 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF10B TNFRSF25
4 hormone activity GO:0005179 8.8 CALCA TG TRH

Sources for Toxic Diffuse Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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