MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 11 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:10719
ICD9CM32 242.00

Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to nodular goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Insulin secretion and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid and whole blood, and related mouse phenotype endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1nodular goiter29.0CALCA, SERPINA7, TG, TPO
2graves' disease12.0
3iatrogenic or traumatic pituitary deficiency10.6TG, TPO
4ovarian endometrioid cystadenoma10.6TG, TPO
5rhabdomyosarcoma, embryonal, 210.5TG, TPO
6demyelinating polyneuropathy10.5TG, TSHR
7malignant syringoma10.5TG, TSHR
8acquired central diabetes insipidus10.5TG, TSHR
9chronic frontal sinusitis10.5TG, TPO
10benign mesothelioma10.4TG, TSHR
11papilledema10.4TG, TRH
12goiter10.4
13tinea corporis10.4SERPINA7, TG
14hypothryoidism, congenital, nongoitrous 410.4TG, TPO
15lung occult adenocarcinoma10.3SERPINA7, TG
16peripheral scars of retina10.3C6orf15, TG, TPO
17crohn's disease of the esophagus10.3TG, TPO, TSHR
18glaucomatocyclitic crisis10.3TG, TSHR
19primary bacterial infectious disease10.3TG, TPO, TSHR
20atrial standstill10.3TG, TPO, TSHR
21intermittent proptosis10.2TG, TPO, TSHR
22dysautonomia, familial10.2TG, TPO
23hemoglobin c disease10.2SERPINA7, TRH
24hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.2SERPINA7, TG, TSHR
25presbyopia10.2SERPINA7, TG, TSHR
26thyroid hormone resistance10.2SERPINA7, TRH
27deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.1TG, TPO
28cardiovascular organ benign neoplasm10.1TG, TRH
29deep angioma10.1CALCA, TG
30acute thyroiditis10.1CALCA, TG
31pleomorphic adenoma10.1CALCA, TG
32mixed endometrial stromal and smooth muscle tumor10.0CALCA, TG
33norwegian scabies10.0CALCA, TG
34hypocomplementemic urticarial vasculitis syndrome10.0CALCA, TG
35bone lymphoma10.0CALCA, TG
36thyroiditis9.9
37malignant mediastinum hemangiopericytoma9.9CALCA, TG, TPO
38substernal goiter9.8CALCA, TG, TSHR
39meckel's diverticulum9.8CALCA, TPO
40richter's syndrome9.8CALCA, TG, TSHR
41craniopharyngioma9.8SERPINA7, TRH
42blood group incompatibility9.8TG, TNFRSF25, TPO, TSHR
43hypothyroidism9.7
44adenoma9.7
45hypertelorism, preauricular sinus, punctal pits, and deafness9.6SERPINA7, TG, TPO, TRH, TSHR
46atheroembolism of kidney9.6SERPINA7, TG, TPO, TRH, TSHR
47meningovascular neurosyphilis9.6CALCA, TG, TPO, TSHR
48hereditary conventional renal cell carcinoma9.6CALCA, TG, TPO, TSHR
49kidney benign neoplasm9.6CALCA, TG, TPO, TSHR
50hashimoto thyroiditis9.6CALCA, TG, TPO, TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

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MGI Mouse Phenotypes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1ABCA1, TG, TNFRSF25, TPO, TRH, TSHR

Drugs & Therapeutics for Toxic Diffuse Goiter

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Drugs for Toxic Diffuse Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
2HormonesPhase 413979
3Hormone AntagonistsPhase 412778
4Antithyroid AgentsPhase 414

Interventional clinical trials:

idNameStatusNCT IDPhase
1Antithyroid Drugs During Radioiodine TherapyCompletedNCT00150137Phase 4
2Block-replacement Therapy During Radioiodine TherapyCompletedNCT00150124Phase 4

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

36
Thyroid, Whole blood

Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6TG, TPO, TSHR
29.2TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

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Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.1ABCA1, PTN, TNFRSF10B, TPO, TSHR
2extracellular regionGO:00055767.5CALCA, PTN, SERPINA7, TG, TNFRSF25, TRH

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.5TG, TPO
2hormone-mediated signaling pathwayGO:000975510.3TRH, TSHR
3thyroid hormone generationGO:00065909.9TG, TPO
4activation of adenylate cyclase activityGO:00071909.9CALCA, TSHR
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.9CALCA, TSHR
6response to lipopolysaccharideGO:00324969.3TG, TNFRSF10B, TNFRSF25

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan bindingGO:000553910.0C6orf15, PTN
2tumor necrosis factor-activated receptor activityGO:00050319.3TNFRSF10B, TNFRSF25

Sources for Toxic Diffuse Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet