MCID: TXC004
MIFTS: 27

Toxic Diffuse Goiter

Categories: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

MalaCards integrated aliases for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10719
ICD9CM 34 242.00

Summaries for Toxic Diffuse Goiter

MalaCards based summary : Toxic Diffuse Goiter is related to graves' disease and plummer's disease. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Amine-derived hormones. Affiliated tissues include thyroid and whole blood, and related phenotype is endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 graves' disease 32.7 DIO2 SERPINA7 TG TPO TSHR
2 plummer's disease 30.3 TG TPO
3 goiter 29.4 CALCA SERPINA7 TG TPO TRH TSHR
4 hypothyroidism 29.2 SERPINA7 TG TPO TRH TSHR
5 nodular goiter 29.2 CALCA TG TPO TSHR
6 graves disease 1 29.1 DIO2 SERPINA7 TG TPO TRH TSHR
7 thyroiditis 28.6 CALCA SERPINA7 TG TPO TRH TSHR
8 familial thyroid dyshormonogenesis 10.5 TG TPO
9 subacute lymphocytic thyroiditis 10.5 TG TPO
10 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TG TPO
11 benign struma ovarii 10.4 TG TSHR
12 athyreosis 10.4 TG TSHR
13 premature menopause 10.4 TG TPO
14 dyshormonogenic goiter 10.4 SERPINA7 TG
15 hypothyroidism, congenital, nongoitrous, 4 10.4 TG TPO
16 struma ovarii 10.4 TG TSHR
17 pernicious anemia 10.4 TG TPO
18 postsurgical hypothyroidism 10.4 TG TRH
19 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.3 TG TPO
20 euthyroid sick syndrome 10.3 DIO2 SERPINA7
21 neonatal hypothyroidism 10.3 TG TPO TSHR
22 myxedema 10.3 TG TPO TSHR
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TG TPO TSHR
24 congenital hypothyroidism 10.2 TG TPO TSHR
25 differentiated thyroid carcinoma 10.2 TG TPO TSHR
26 exophthalmos 10.2 TG TSHR
27 hypothyroidism, congenital, nongoitrous, 2 10.2 SERPINA7 TG TSHR
28 thyroid hormone resistance, generalized, autosomal dominant 10.1 SERPINA7 TG TRH
29 mucoepidermoid thyroid carcinoma 10.1 CALCA TG
30 suppurative thyroiditis 10.1 CALCA TG
31 thyroid sarcoma 10.1 CALCA TG
32 chromophobe adenoma 10.1 SERPINA7 TRH
33 atypical follicular adenoma 10.0 CALCA TG
34 acute thyroiditis 10.0 CALCA TG
35 endocrine organ benign neoplasm 10.0 TG TRH
36 subacute thyroiditis 10.0 SERPINA7 TG TPO TSHR
37 hypoadrenalism 10.0 CALCA TG
38 celiac disease 1 10.0 TG TNFRSF25 TPO
39 diffuse scleroderma 10.0 TNFRSF10B TNFRSF25
40 immune system disease 10.0 TG TNFRSF25 TSHR
41 amyloid tumor 9.9 CALCA TG
42 ovarian cystic teratoma 9.9 CALCA TG
43 hyperthyroxinemia 9.9 SERPINA7 TPO TRH TSHR
44 papillary thyroid microcarcinoma 9.8 CALCA TG TSHR
45 hypersensitivity reaction disease 9.8 TG TNFRSF25 TPO TSHR
46 adenoma 9.8
47 postpartum depression 9.8 CALCA TPO
48 hyperthyroidism 9.7 SERPINA7 TG TPO TRH TSHR
49 multinodular goiter 9.7 CALCA TG TPO TSHR
50 follicular adenoma 9.7 CALCA TG TPO TSHR

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to Toxic Diffuse Goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 ABCA1 DIO2 TG TNFRSF25 TPO TRH

Drugs & Therapeutics for Toxic Diffuse Goiter

Search Clinical Trials , NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

MalaCards organs/tissues related to Toxic Diffuse Goiter:

38
Thyroid, Whole Blood

Publications for Toxic Diffuse Goiter

Articles related to Toxic Diffuse Goiter:

(show all 24)
# Title Authors Year
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. ( 21660794 )
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. ( 12213665 )
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. ( 7951488 )
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. ( 3413443 )
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. ( 2445808 )
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. ( 6131902 )
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 6162933 )
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. ( 94089 )
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. ( 627898 )
1978
10
The choice of therapy in toxic diffuse goiter. ( 80165 )
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. ( 576614 )
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. ( 69022 )
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. ( 4665962 )
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. ( 5281463 )
1971
15
Toxic diffuse goiter in children. ( 5819609 )
1969
16
Treatment of toxic diffuse goiter. ( 4183010 )
1969
17
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. ( 5257435 )
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). ( 13457495 )
1957
19
Chronic treatment of toxic diffuse goiter. ( 13457490 )
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. ( 14929372 )
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. ( 14810187 )
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. ( 14771065 )
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. ( 18146931 )
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. ( 21002593 )
1946

Variations for Toxic Diffuse Goiter

Expression for Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for Toxic Diffuse Goiter

GO Terms for Toxic Diffuse Goiter

Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 C6orf15 CALCA PTN SERPINA7 TG TNFRSF25
2 cell surface GO:0009986 9.02 ABCA1 PTN TNFRSF10B TPO TSHR

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.71 CALCA PTN TG TRH
2 activation of adenylate cyclase activity GO:0007190 9.46 CALCA TSHR
3 hormone-mediated signaling pathway GO:0009755 9.43 TRH TSHR
4 thyroid hormone generation GO:0006590 9.37 DIO2 TPO
5 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.33 ABCA1 CALCA TSHR
6 positive regulation of adenylate cyclase activity GO:0045762 9.32 CALCA TSHR
7 thyroid hormone metabolic process GO:0042403 9.26 DIO2 TG
8 positive regulation of cAMP biosynthetic process GO:0030819 9.13 ABCA1 CALCA TSHR
9 hormone biosynthetic process GO:0042446 8.8 DIO2 TG TPO

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.33 TNFRSF10B TNFRSF25 TSHR
2 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF10B TNFRSF25
3 hormone activity GO:0005179 8.8 CALCA TG TRH

Sources for Toxic Diffuse Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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