MCID: TXC004
MIFTS: 33

Toxic Diffuse Goiter malady

Endocrine diseases category

Summaries for Toxic Diffuse Goiter

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34MalaCards
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MalaCards: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Allograft rejection and Insulin secretion. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are endocrine/exocrine gland and growth/size/body.

Aliases & Classifications for Toxic Diffuse Goiter

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

toxic diffuse goiter 9 11 46 63


External Ids:

Disease Ontology9 DOID:10719
ICD9CM28 242.00

Related Diseases for Toxic Diffuse Goiter

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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34MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

34
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5TSHR, TG, TPO
2MP:00053787.9TDG, TSHR, TG, TPO
3MP:00053767.7TPO, TG, TSHR, TDG

Publications for Toxic Diffuse Goiter

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53PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

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Pathways for genes affiliated with Toxic Diffuse Goiter

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome
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Compounds for genes affiliated with Toxic Diffuse Goiter

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR, 3BitterDB, 62Tocris Bioscience
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Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1carbimazole46 1210.7TSHR, TPO
2amino acid469.7TPO, TSHR
3maltose46 1210.7TPO, TSHR
4asparagine469.7TPO, TSHR
5cytosine46 2510.7TDG, TSHR
6iodotyrosine46 2510.6TG, TPO
7diiodotyrosine469.6TG, TPO
8perchlorate469.5TG, TPO
9adenine46 25 1211.5TSHR, TDG
10gliadin469.5TG, TPO
11chromium469.5TPO, TG
12amiodarone46 52 30 1212.5TG, TPO
13cardiolipin46 1210.5TG, TPO
14selenium46 2510.5TPO, TG
15agarose469.5TSHR, TPO
16sodium dodecylsulfate469.4TG, TPO
17acth469.4TSHR, TPO
18hydrocortisone46 3 62 1212.4TG, TPO
19gold469.4TG, TPO
20prednisolone46 30 1211.3TSHR, TG
21sialic acid469.3TSHR, TG
22histidine469.2TPO, TSHR
23carbohydrates469.2TSHR, TG
24mannose469.1TG, TSHR
25ascorbic acid46 2510.1TG, TPO
2612-o-tetradecanoylphorbol 13-acetate469.0TPO, TSHR
27sodium iodide469.0TSHR, TG, TPO
28propylthiouracil46 3 1211.0TSHR, TG, TPO
29iodine46 259.9TPO, TG, TSHR
30125i468.9TSHR, TG, TPO
31iodide46 259.9TPO, TG, TSHR
32methimazole46 3 1210.9TSHR, TG, TPO
33triiodothyronine468.9TPO, TG, TSHR
34thyroxine46 259.9TPO, TG, TSHR
35guanine46 25 1210.9TG, TSHR, TDG
36ribonucleic acid468.9TSHR, TG, TPO
37polysaccharide468.9TSHR, TG, TPO
38sodium46 259.9TSHR, TG, TPO
39aspartate468.9TPO, TG, TSHR
40adenylate468.9TSHR, TG, TPO
41arginine468.9TSHR, TG, TPO
42glutamate468.8TSHR, TG, TPO
43estrogen468.8TG, TSHR, TDG
44retinoic acid46 259.8TSHR, TG, TPO
45cysteine468.8TPO, TG, TSHR
46tyrosine468.5TSHR, TG, TPO

GO Terms for genes affiliated with Toxic Diffuse Goiter

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17Gene Ontology
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Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TG, TPO
2hormone biosynthetic processGO:0424468.8TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Toxic Diffuse Goiter

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet