Toxic Diffuse Goiter malady

MalaCards: Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways is Autoimmune thyroid disease. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotype growth/size.

Aliases & Descriptions:

toxic diffuse goiter 6 8 32 43

Diseases related to toxic diffuse goiter by text searches and GeneDecks gene sharing:

(show top 50)    (show all 66)

id	Related Disease	Score	Top Affiliating Genes
1	graves' disease	30.2	TG, TPO, TSHR
2	goiter	29.6	TG, TPO, TSHR, TDG
3	thyroiditis	27.8	TPO, TSHR, TDG, TG
4	thyrotoxic periodic paralysis	12.8	TSHR, TPO
5	hyperthyroxinemia	12.7	TPO, TSHR
6	iodine hypothyroidism	12.6	TG, TPO
7	hashimoto's encephalitis	12.6	TG, TPO
8	total iodide organification defect	12.6	TG, TPO
9	megaloblastic anemia	12.6	TPO, TG
10	hellp syndrome	12.6	TSHR, TPO
11	premature menopause	12.6	TPO, TG
12	plummer's disease	12.6	TG, TPO
13	thyrotropin deficiency, isolated	12.6	TG, TPO
14	endogenous depression	12.6	TPO, TG
15	pendred syndrome	12.5	TG, TPO
16	limbic encephalitis	12.5	TPO, TG
17	subacute thyroiditis	12.5	TPO, TG
18	autoimmune polyendocrine syndrome	12.5	TG, TPO
19	thyroid hormone metabolism	12.5	TG, TPO
20	neuroectodermal endocrine syndrome	12.5	TPO, TG
21	struma ovarii	12.5	TSHR, TG
22	thyroid agenesis	12.5	TSHR, TG
23	sycp3-related pregnancy loss, susceptibility to	12.5	TG, TPO
24	follicular adenoma	12.5	TPO, TG
25	diabetic ketoacidosis	12.4	TG, TPO
26	thyroid cancer, follicular	12.4	TG, TSHR
27	mumps	12.4	TG, TPO
28	addison's disease	12.3	TPO, TG
29	turner syndrome	12.3	TPO, TG
30	dwarfism	12.2	TG, TPO
31	glucose intolerance	12.2	TSHR, TPO
32	rubella	12.2	TG, TPO
33	stickler syndrome	12.0	TSHR, TG
34	mucinoses	12.0	TG, TPO, TSHR
35	neonatal hypothyroidism	12.0	TG, TSHR, TPO
36	nontoxic goiter	12.0	TPO, TG, TSHR
37	myxedema	12.0	TPO, TG, TSHR
38	nodular goiter	12.0	TPO, TSHR, TG
39	anaplastic carcinoma	12.0	TPO, TSHR, TG
40	multinodular goiter	12.0	TPO, TG, TSHR
41	thyrotoxicosis	12.0	TPO, TSHR, TG
42	thyroid cancer, anaplastic	12.0	TG, TPO, TSHR
43	endemic goiter	12.0	TSHR, TG, TPO
44	thyroid medullary carcinoma	12.0	TSHR, TG, TPO
45	congenital hypothyroidism	12.0	TSHR, TG, TPO
46	thyroid adenoma	12.0	TSHR, TPO, TG
47	diabetes insipidus	12.0	TSHR, TPO, TG
48	candidiasis	12.0	TPO, TSHR, TG
49	mayer-rokitansky-kuster-hauser syndrome	11.9	TPO, TG, TSHR
50	type 1 diabetes mellitus	11.9	TG, TPO, TSHR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to toxic diffuse goiter:

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MGI Mouse Phenotypes related to toxic diffuse goiter:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	8.0	TPO, TSHR, TG, TDG

Articles related to toxic diffuse goiter:

id	Title	Authors	Year	Affiliating Genes
1	Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)	Cardoso L.C.... Carvalho D.P.	2002	TPO
2	Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)	Hosaka Y.... Hosoya T.	1993	TPO

Genes related to toxic diffuse goiter according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	TPO	thyroid peroxidase	11.0	Publications
2	TSHR	thyroid stimulating hormone receptor	11.0
3	TG	thyroglobulin	11.0
4	TDG	thymine-DNA glycosylase	11.0

Pathways related to toxic diffuse goiter according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Autoimmune thyroid disease20	8.5	TPO, TSHR, TG

Compounds related to toxic diffuse goiter according to GeneDecks:

(show all 36)

id	Compound	Score	Top Affiliating Genes
1	carbimazole32 9 9	11.7	TPO, TSHR
2	amino acid32	9.7	TPO, TSHR
3	maltose32 9 9	11.7	TSHR, TPO
4	asparagine32	9.6	TPO, TSHR
5	cytosine32 18	10.6	TDG, TSHR
6	iodotyrosine32 18	10.5	TPO, TG
7	diiodotyrosine32	9.5	TPO, TG
8	perchlorate32	9.5	TPO, TG
9	gliadin32	9.5	TPO, TG
10	chromium32	9.5	TG, TPO
11	amiodarone32 9 9	11.4	TG, TPO
12	cardiolipin32 9 9	11.4	TPO, TG
13	selenium32 18	10.4	TPO, TG
14	agarose32	9.3	TPO, TSHR
15	sodium dodecylsulfate32	9.3	TG, TPO
16	hydrocortisone32 9 9	11.2	TPO, TG
17	prednisolone32 9 9	11.1	TG, TSHR
18	gold32	9.1	TPO, TG
19	adenine32 9 18 9	12.0	TSHR, TDG
20	sialic acid32	8.9	TG, TSHR
21	sodium iodide32	8.9	TPO, TSHR, TG
22	propylthiouracil32 9 9	10.9	TG, TSHR, TPO
23	iodine32 18	9.9	TPO, TSHR, TG
24	125i32	8.9	TG, TSHR, TPO
25	iodide32 18	9.9	TPO, TSHR, TG
26	methimazole32 9 9	10.9	TG, TSHR, TPO
27	triiodothyronine32	8.9	TG, TSHR, TPO
28	thyroxine32 18	9.9	TPO, TSHR, TG
29	guanine32 9 18 9	11.9	TDG, TG, TSHR
30	ribonucleic acid32	8.9	TG, TSHR, TPO
31	polysaccharide32	8.8	TPO, TSHR, TG
32	sodium32 18	9.8	TG, TSHR, TPO
33	aspartate32	8.8	TPO, TSHR, TG
34	adenylate32	8.8	TG, TSHR, TPO
35	arginine32	8.7	TPO, TSHR, TG
36	glutamate32	8.7	TPO, TSHR, TG

Biological processes related to toxic diffuse goiter according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	9.1	TPO, TG