MCID: TXC004
MIFTS: 28

Toxic Diffuse Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Toxic Diffuse Goiter

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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter 11 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:10719
ICD9CM32 242.00

Summaries for Toxic Diffuse Goiter

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MalaCards based summary: Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Amine-derived hormones and Insulin secretion. Affiliated tissues include thyroid and whole blood, and related mouse phenotype endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1graves' disease11.9
2goiter10.4
3fibrous meningioma10.3TG, TPO
4premature closure of the arterial duct10.3TG, TPO
5acute hemorrhagic encephalitis10.3TG, TSHR
6tick paralysis10.3TG, TPO
7mesocardia10.3TG, TSHR
8atheroembolism of kidney10.3TG, TRH
9parachordoma10.2TG, TSHR
10echinostomiasis10.2SERPINA7, TG
11frontal sinusitis10.2TG, TPO
12caudal regression syndrome10.2TG, TPO
13color blindness10.2TG, TPO
14neuhauser daly magnelli syndrome10.2TG, TPO, TSHR
15conjunctival deposit10.2TG, TPO, TSHR
16denys-drash syndrome10.2TG, TPO, TSHR
17commensal bacterial infectious disease10.2TG, TPO, TSHR
18choreoathetosis, hypothyroidism, and neonatal respiratory distress10.2TG, TPO, TSHR
19non-distal monosomy 10q10.2TG, TPO, TSHR
20extrahepatic bile duct adenocarcinoma10.2SERPINA7, TG, TPO
21endophthalmitis10.2CALCA, TG
22neuronopathy, distal hereditary motor, type viia10.2SERPINA7, TG, TSHR
23articulation disorder10.2TG, TPO, TSHR
24corneal ectasia10.1CALCA, TG
25superior vena cava angiosarcoma10.1CALCA, TG
26congenital nonspherocytic hemolytic anemia10.1SERPINA7, TPO, TRH
27acute laryngitis10.1TG, TSHR
28perineural angioma10.1CALCA, TG
29parietal lobe neoplasm10.1CALCA, TG
30glucosephosphate dehydrogenase deficiency10.1DIO2, SERPINA7
31hypogonadism cardiomyopathy10.1CALCA, TG
32thyroid hormone resistance, autosomal recessive10.1SERPINA7, TRH
33rheumatic fever10.1TNFRSF10B, TNFRSF25
34background diabetic retinopathy10.1SERPINA7, TG, TPO, TSHR
35mixed eosinophil-basophil adenoma10.1SERPINA7, TG, TPO, TSHR
36gastrinoma10.1CALCA, TG, TSHR
37dysautonomia, familial10.0TG, TPO
38childhood vagina botryoid rhabdomyosarcoma10.0CALCA, TG
39cowden syndrome 310.0CALCA, TG
40nodular prostate10.0CALCA, TG, TPO, TSHR
41exanthema subitum10.0CALCA, TG, TPO, TSHR
42peritoneal serous papillary adenocarcinoma10.0CALCA, TG, TPO, TSHR
43tenosynovitis of foot and ankle10.0CALCA, TG, TPO, TSHR
44diabetes mellitus, insulin-dependent, 129.9CALCA, TG, TPO, TSHR
45peritoneal mesothelioma9.9CALCA, TG, TPO, TSHR
46hypothyroidism, congenital, nongoitrous, 19.9SERPINA7, TG, TPO, TRH, TSHR
47glomangiomyoma9.9SERPINA7, TG, TPO, TRH, TSHR
48cholesterol embolism9.9SERPINA7, TG, TPO, TRH, TSHR
49janus kinase-3 deficiency9.9SERPINA7, TG, TNFRSF25, TPO, TSHR
50thyroiditis9.9

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms & Phenotypes for Toxic Diffuse Goiter

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MGI Mouse Phenotypes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5ABCA1, DIO2, TG, TNFRSF25, TPO, TRH

Drugs & Therapeutics for Toxic Diffuse Goiter

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Drugs for Toxic Diffuse Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
2HormonesPhase 414415
3Hormone AntagonistsPhase 413180
4Antithyroid AgentsPhase 415

Interventional clinical trials:

idNameStatusNCT IDPhase
1Antithyroid Drugs During Radioiodine TherapyCompletedNCT00150137Phase 4
2Block-replacement Therapy During Radioiodine TherapyCompletedNCT00150124Phase 4

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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MalaCards organs/tissues related to Toxic Diffuse Goiter:

36
Thyroid, Whole blood

Publications for Toxic Diffuse Goiter

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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Toxic diffuse goiter in children. (5819609)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Treatment of toxic diffuse goiter. (4183010)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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GO Terms for genes affiliated with Toxic Diffuse Goiter

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Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.2ABCA1, PTN, TNFRSF10B, TPO, TSHR
2extracellular regionGO:00055767.5C6orf15, CALCA, PTN, SERPINA7, TG, TNFRSF25

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated signaling pathwayGO:000975510.3TRH, TSHR
2activation of adenylate cyclase activityGO:000719010.1CALCA, TSHR
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:000718910.1CALCA, TSHR
4positive regulation of adenylate cyclase activityGO:004576210.0CALCA, TSHR
5hormone biosynthetic processGO:00424469.7DIO2, TG, TPO
6thyroid hormone generationGO:00065909.6DIO2, TPO
7positive regulation of cAMP biosynthetic processGO:00308199.5ABCA1, CALCA, TSHR
8thyroid hormone metabolic processGO:00424039.4DIO2, TG

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosaminoglycan bindingGO:000553910.3C6orf15, PTN
2hormone activityGO:00051799.8CALCA, TG, TRH
3receptor activityGO:00048729.5TNFRSF10B, TNFRSF25, TSHR
4tumor necrosis factor-activated receptor activityGO:00050319.5TNFRSF10B, TNFRSF25

Sources for Toxic Diffuse Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet