Toxic Diffuse Goiter disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Toxic Diffuse Goiter

MalaCards based summary: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Allograft rejection and Insulin secretion. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are endocrine/exocrine gland and growth/size/body.

Aliases & Classifications for Toxic Diffuse Goiter

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ²⁸ICD9CM
See all sources

Toxic Diffuse Goiter, Aliases & Descriptions:

Name: Toxic Diffuse Goiter ⁹ ¹¹ ⁴⁴ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases

External Ids:

Disease Ontology⁹ DOID:10719

ICD9CM²⁸ 242.00

UMLS⁶¹ C0154138

Related Diseases for Toxic Diffuse Goiter

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)

id	Related Disease	Score	Top Affiliating Genes
1	goiter	31.0	TPO, TG, TSHR
2	graves' disease	30.5	TPO, TG, TSHR
3	thyrotoxicosis	30.2	TSHR, TG, TPO
4	thyroiditis	30.2	TPO, TG, TSHR
5	nodular goiter	30.0	TSHR, TG, TPO
6	hypothyroidism	30.0	TPO, TG, TSHR
7	adenoma	29.7	TSHR, TG, TPO
8	hyperthyroxinemia	10.1	TSHR, TPO
9	pernicious anemia	10.0	TPO, TG
10	plummer's disease	10.0	TG, TPO
11	thyrotropin deficiency, isolated	10.0	TPO, TG
12	autoimmune thyroiditis	10.0	TG, TPO
13	pendred syndrome	10.0	TG, TPO
14	systemic lupus erythematosus	10.0	TSHR, TPO
15	thyroid agenesis	10.0	TG, TSHR
16	struma ovarii	10.0	TSHR, TG
17	turner syndrome	10.0	TPO, TG
18	pregnancy loss	9.9	TG, TPO
19	follicular thyroid carcinoma	9.9	TG, TSHR
20	addison's disease	9.9	TPO, TG
21	celiac disease	9.8	TG, TPO
22	down syndrome	9.8	TSHR, TPO
23	subacute thyroiditis	9.8	TPO, TG, TSHR
24	endemic goiter	9.8	TSHR, TG, TPO
25	nontoxic goiter	9.8	TPO, TG, TSHR
26	multinodular goiter	9.8	TPO, TG, TSHR
27	myxedema	9.8	TPO, TG, TSHR
28	congenital hypothyroidism	9.8	TSHR, TG, TPO
29	thyroid adenoma	9.8	TPO, TG, TSHR
30	thyroid cancer, anaplastic	9.8	TPO, TG, TSHR
31	follicular adenoma	9.8	TSHR, TG, TPO
32	hyperthyroidism	9.8	TSHR, TG, TPO
33	papillary carcinoma	9.8	TPO, TG, TSHR
34	papillary thyroid carcinoma	9.8	TSHR, TG, TPO
35	thyroid hurthle cell carcinoma	9.8	TSHR, TG, TPO
36	type 1 diabetes mellitus	9.7	TPO, TG, TSHR
37	hypersensitivity reaction type ii disease	9.7	TSHR, TG, TPO

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:

Symptoms for Toxic Diffuse Goiter

Drugs & Therapeutics for Toxic Diffuse Goiter

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Toxic Diffuse Goiter

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

Sources:
³²MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

³²

Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.5	TSHR, TG, TPO
2	growth/size/body phenotype	MP:0005378	7.9	TDG, TSHR, TG, TPO
3	homeostasis/metabolism phenotype	MP:0005376	7.7	TPO, TG, TSHR, TDG

Publications for Toxic Diffuse Goiter

Sources:
⁵¹PubMed
See all sources

Articles related to Toxic Diffuse Goiter:

(show all 24)

id	Title	Authors	Year
1	Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)	Savchenko O.V.... Toupeleev P.A.	2012
2	Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)	Cardoso L.C.... Carvalho D.P.	2002
3	Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)	Hosaka Y.... Hosoya T.	1993
4	Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)	Kamel N.... Polat H.	1988
5	Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)	Ericsson U.B.... Thorell J.I.	1987
6	HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)	Schleusener H.... Wenzel K.W.	1983
7	Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)	Heggi F.N.	1981
8	Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)	Steinbach J.J.... Goldman J.K.	1979
9	The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)	Von Hofe S.E.... Young R.L.	1978
10	The choice of therapy in toxic diffuse goiter. (80165)	Young R.L.... Dorfman S.G.	1978
11	Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)	Nagataki S.... Masuyama Y.	1977
12	Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)	Barnes H.V.... Blizzard R.M.	1977
13	I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)	Yang H.F.	1972
14	I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)	Yang H.F.	1971
15	Treatment of toxic diffuse goiter. (4183010)	Stanbury J.B.	1969
16	I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)	Yang H.F.... Chen C.C.	1969
17	Toxic diffuse goiter in children. (5819609)	Mosier H.D.	1969
18	The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)	BLOOMFIELD A.L.	1957
19	Chronic treatment of toxic diffuse goiter. (13457490)	REVENO W.S.... Rosenbaum H.	1957
20	Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)	SELIGMAN B.	1952
21	Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)	Topper A.	1951
22	Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)	GREENBERG S.U.... BRUGER M.	1950
23	Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)	PRINZMETAL M.... AGRESS C.M.	1949
24	The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)	McKNIGHT R.B.	1946

Genes related to Toxic Diffuse Goiter

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Toxic Diffuse Goiter:

- Elite gene

id	Symbol	Description	Score	Implication
1	TPO	thyroid peroxidase	22.70	GeneCards inferred via : Publications, Disorders (show sections)
2	TSHR	thyroid stimulating hormone receptor	17.70	GeneCards inferred via : Disorders (show sections)
3	TG	thyroglobulin	12.70	GeneCards inferred via : Disorders (show sections)
4	TDG	thymine-DNA glycosylase	7.58	GeneCards inferred via : Disorders (show sections)

Products for genes related to Toxic Diffuse Goiter disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	4	-	4	4
2	Novus Biologicals	4	3	4	-

Variations for Toxic Diffuse Goiter

Expression for genes affiliated with Toxic Diffuse Goiter

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

Sources:
⁴⁹PathCards, ³⁰KEGG, ³⁷NCBI BioSystems Database, ⁵²QIAGEN, ⁵⁴Reactome
See all sources

Pathways related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	8.5	TSHR, TG, TPO
2	Insulin secretion³⁰ Show member pathways Ca2+ activated K+ channels⁵⁴ Thyroid hormone synthesis³⁰	8.5	TSHR, TG, TPO
3	Thyroxine (Thyroid Hormone) Production³⁷	8.5	TSHR, TG, TPO

Compounds for genes affiliated with Toxic Diffuse Goiter

Sources:
⁴⁴Novoseek, ¹²DrugBank, ²⁵HMDB, ⁵⁰PharmGKB, ²⁹IUPHAR, ³BitterDB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 46)

id	Compound	Score	Top Affiliating Genes
1	carbimazole⁴⁴ ¹²	10.7	TSHR, TPO
2	amino acid⁴⁴	9.7	TPO, TSHR
3	maltose⁴⁴ ¹²	10.7	TPO, TSHR
4	asparagine⁴⁴	9.7	TPO, TSHR
5	cytosine⁴⁴ ²⁵	10.7	TDG, TSHR
6	iodotyrosine⁴⁴ ²⁵	10.6	TG, TPO
7	diiodotyrosine⁴⁴	9.6	TG, TPO
8	perchlorate⁴⁴	9.5	TG, TPO
9	adenine⁴⁴ ²⁵ ¹²	11.5	TSHR, TDG
10	gliadin⁴⁴	9.5	TG, TPO
11	chromium⁴⁴	9.5	TPO, TG
12	amiodarone⁴⁴ ⁵⁰ ²⁹ ¹²	12.5	TG, TPO
13	cardiolipin⁴⁴ ¹²	10.5	TG, TPO
14	selenium⁴⁴ ²⁵	10.5	TPO, TG
15	agarose⁴⁴	9.5	TSHR, TPO
16	sodium dodecylsulfate⁴⁴	9.4	TG, TPO
17	acth⁴⁴	9.4	TSHR, TPO
18	hydrocortisone⁴⁴ ³ ⁶⁰ ¹²	12.4	TG, TPO
19	gold⁴⁴	9.4	TG, TPO
20	prednisolone⁴⁴ ²⁹ ¹²	11.3	TSHR, TG
21	sialic acid⁴⁴	9.3	TSHR, TG
22	histidine⁴⁴	9.2	TPO, TSHR
23	carbohydrates⁴⁴	9.2	TSHR, TG
24	mannose⁴⁴	9.1	TG, TSHR
25	ascorbic acid⁴⁴ ²⁵	10.1	TG, TPO
26	12-o-tetradecanoylphorbol 13-acetate⁴⁴	9.0	TPO, TSHR
27	sodium iodide⁴⁴	9.0	TSHR, TG, TPO
28	propylthiouracil⁴⁴ ³ ¹²	11.0	TSHR, TG, TPO
29	iodine⁴⁴ ²⁵	9.9	TPO, TG, TSHR
30	125i⁴⁴	8.9	TSHR, TG, TPO
31	iodide⁴⁴ ²⁵	9.9	TPO, TG, TSHR
32	methimazole⁴⁴ ³ ¹²	10.9	TSHR, TG, TPO
33	triiodothyronine⁴⁴	8.9	TPO, TG, TSHR
34	thyroxine⁴⁴ ²⁵	9.9	TPO, TG, TSHR
35	guanine⁴⁴ ²⁵ ¹²	10.9	TG, TSHR, TDG
36	ribonucleic acid⁴⁴	8.9	TSHR, TG, TPO
37	polysaccharide⁴⁴	8.9	TSHR, TG, TPO
38	sodium⁴⁴ ²⁵	9.9	TSHR, TG, TPO
39	aspartate⁴⁴	8.9	TPO, TG, TSHR
40	adenylate⁴⁴	8.9	TSHR, TG, TPO
41	arginine⁴⁴	8.9	TSHR, TG, TPO
42	glutamate⁴⁴	8.8	TSHR, TG, TPO
43	estrogen⁴⁴	8.8	TG, TSHR, TDG
44	retinoic acid⁴⁴ ²⁵	9.8	TSHR, TG, TPO
45	cysteine⁴⁴	8.8	TPO, TG, TSHR
46	tyrosine⁴⁴	8.5	TSHR, TG, TPO

GO Terms for genes affiliated with Toxic Diffuse Goiter

Sources:
¹⁷Gene Ontology
See all sources

Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	thyroid hormone generation	GO:006590	9.1	TG, TPO
2	hormone biosynthetic process	GO:042446	8.8	TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Toxic Diffuse Goiter

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: TXC004 MIFTS: 33	Toxic Diffuse Goiter malady Endocrine diseases category
4 genes, 2 tissues, 37 related diseases, clinical trials Download this MalaCard Expand all tables

Toxic Diffuse Goiter malady