Toxic Diffuse Goiter disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Toxic Diffuse Goiter

Sources:
¹¹Disease Ontology, ¹³DISEASES, ³²ICD9CM, ⁵⁰Novoseek, ⁶⁸UMLS
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Aliases & Descriptions for Toxic Diffuse Goiter:

Name: Toxic Diffuse Goiter ¹¹ ⁵⁰ ¹³ ⁶⁸

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹¹ DOID:10719

ICD9CM³² 242.00

UMLS⁶⁸ C0154138

Summaries for Toxic Diffuse Goiter

Sources:
³⁶MalaCards
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MalaCards based summary: Toxic Diffuse Goiter is related to graves' disease and goiter. An important gene associated with Toxic Diffuse Goiter is TG (Thyroglobulin), and among its related pathways are Amine-derived hormones and Insulin secretion. Affiliated tissues include thyroid and whole blood, and related mouse phenotype endocrine/exocrine gland.

Related Diseases for Toxic Diffuse Goiter

Sources:
²⁰GeneAnalytics, ²¹GeneCards
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Diseases related to Toxic Diffuse Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)

id	Related Disease	Score	Top Affiliating Genes
1	graves' disease	11.9
2	goiter	10.4
3	fibrous meningioma	10.3	TG, TPO
4	premature closure of the arterial duct	10.3	TG, TPO
5	acute hemorrhagic encephalitis	10.3	TG, TSHR
6	tick paralysis	10.3	TG, TPO
7	mesocardia	10.3	TG, TSHR
8	atheroembolism of kidney	10.3	TG, TRH
9	parachordoma	10.2	TG, TSHR
10	echinostomiasis	10.2	SERPINA7, TG
11	frontal sinusitis	10.2	TG, TPO
12	caudal regression syndrome	10.2	TG, TPO
13	color blindness	10.2	TG, TPO
14	neuhauser daly magnelli syndrome	10.2	TG, TPO, TSHR
15	conjunctival deposit	10.2	TG, TPO, TSHR
16	denys-drash syndrome	10.2	TG, TPO, TSHR
17	commensal bacterial infectious disease	10.2	TG, TPO, TSHR
18	choreoathetosis, hypothyroidism, and neonatal respiratory distress	10.2	TG, TPO, TSHR
19	non-distal monosomy 10q	10.2	TG, TPO, TSHR
20	extrahepatic bile duct adenocarcinoma	10.2	SERPINA7, TG, TPO
21	endophthalmitis	10.2	CALCA, TG
22	neuronopathy, distal hereditary motor, type viia	10.2	SERPINA7, TG, TSHR
23	articulation disorder	10.2	TG, TPO, TSHR
24	corneal ectasia	10.1	CALCA, TG
25	superior vena cava angiosarcoma	10.1	CALCA, TG
26	congenital nonspherocytic hemolytic anemia	10.1	SERPINA7, TPO, TRH
27	acute laryngitis	10.1	TG, TSHR
28	perineural angioma	10.1	CALCA, TG
29	parietal lobe neoplasm	10.1	CALCA, TG
30	glucosephosphate dehydrogenase deficiency	10.1	DIO2, SERPINA7
31	hypogonadism cardiomyopathy	10.1	CALCA, TG
32	thyroid hormone resistance, autosomal recessive	10.1	SERPINA7, TRH
33	rheumatic fever	10.1	TNFRSF10B, TNFRSF25
34	background diabetic retinopathy	10.1	SERPINA7, TG, TPO, TSHR
35	mixed eosinophil-basophil adenoma	10.1	SERPINA7, TG, TPO, TSHR
36	gastrinoma	10.1	CALCA, TG, TSHR
37	dysautonomia, familial	10.0	TG, TPO
38	childhood vagina botryoid rhabdomyosarcoma	10.0	CALCA, TG
39	cowden syndrome 3	10.0	CALCA, TG
40	nodular prostate	10.0	CALCA, TG, TPO, TSHR
41	exanthema subitum	10.0	CALCA, TG, TPO, TSHR
42	peritoneal serous papillary adenocarcinoma	10.0	CALCA, TG, TPO, TSHR
43	tenosynovitis of foot and ankle	10.0	CALCA, TG, TPO, TSHR
44	diabetes mellitus, insulin-dependent, 12	9.9	CALCA, TG, TPO, TSHR
45	peritoneal mesothelioma	9.9	CALCA, TG, TPO, TSHR
46	hypothyroidism, congenital, nongoitrous, 1	9.9	SERPINA7, TG, TPO, TRH, TSHR
47	glomangiomyoma	9.9	SERPINA7, TG, TPO, TRH, TSHR
48	cholesterol embolism	9.9	SERPINA7, TG, TPO, TRH, TSHR
49	janus kinase-3 deficiency	9.9	SERPINA7, TG, TNFRSF25, TPO, TSHR
50	thyroiditis	9.9

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:

Symptoms & Phenotypes for Toxic Diffuse Goiter

Sources:
⁴¹MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	7.5	ABCA1, DIO2, TG, TNFRSF25, TPO, TRH

Drugs & Therapeutics for Toxic Diffuse Goiter

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Toxic Diffuse Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Hormones, Hormone Substitutes, and Hormone Antagonists		Phase 4	13168
2	Hormones		Phase 4	14415
3	Hormone Antagonists		Phase 4	13180
4	Antithyroid Agents		Phase 4	15

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Antithyroid Drugs During Radioiodine Therapy	Completed	NCT00150137	Phase 4
2	Block-replacement Therapy During Radioiodine Therapy	Completed	NCT00150124	Phase 4

Search NIH Clinical Center for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

Anatomical Context for Toxic Diffuse Goiter

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

³⁶

Thyroid, Whole blood

Publications for Toxic Diffuse Goiter

Sources:
⁵⁷PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 24)

id	Title	Authors	Year
1	Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)	Savchenko O.V.... Toupeleev P.A.	2012
2	Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)	Cardoso L.C.... Carvalho D.P.	2002
3	Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)	Hosaka Y.... Hosoya T.	1993
4	Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)	Kamel N.... Polat H.	1988
5	Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)	Ericsson U.B.... Thorell J.I.	1987
6	HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)	Schleusener H.... Wenzel K.W.	1983
7	Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)	Heggi F.N.	1981
8	Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)	Steinbach J.J.... Goldman J.K.	1979
9	The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)	Von Hofe S.E.... Young R.L.	1978
10	The choice of therapy in toxic diffuse goiter. (80165)	Young R.L.... Dorfman S.G.	1978
11	Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)	Nagataki S.... Masuyama Y.	1977
12	Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)	Barnes H.V.... Blizzard R.M.	1977
13	I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)	Yang H.F.	1972
14	I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)	Yang H.F.	1971
15	Toxic diffuse goiter in children. (5819609)	Mosier H.D.	1969
16	I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)	Yang H.F.... Chen C.C.	1969
17	Treatment of toxic diffuse goiter. (4183010)	Stanbury J.B.	1969
18	The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)	Bloomfield A.L.	1957
19	Chronic treatment of toxic diffuse goiter. (13457490)	REVENO W.S.... Rosenbaum H.	1957
20	Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)	SELIGMAN B.	1952
21	Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)	Topper A.	1951
22	Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)	GREENBERG S.U.... BRUGER M.	1950
23	Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)	PRINZMETAL M.... AGRESS C.M.	1949
24	The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)	McKNIGHT R.B.	1946

Genes related to Toxic Diffuse Goiter

Sources:
¹³DISEASES, ²¹GeneCards, ⁵⁰Novoseek
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Genes related to Toxic Diffuse Goiter:

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	TG	Thyroglobulin	33.48	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	1422230, 11873391
2	TPO	Thyroid Peroxidase	27.69	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	7951488, 1422230, 11549671 more 11600551, 12213665
3	TDG	Thymine DNA Glycosylase	25.80	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
4	C6orf15	Chromosome 6 Open Reading Frame 15	23.74	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
5	TSHR	Thyroid Stimulating Hormone Receptor	23.54	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	1658772
6	SERPINA7	Serpin Family A Member 7	23.37	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
7	TRH	Thyrotropin Releasing Hormone	22.73	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
8	ABCA1	ATP Binding Cassette Subfamily A Member 1	22.63	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
9	TNFRSF10B	TNF Receptor Superfamily Member 10b	22.58	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
10	TNFRSF25	TNF Receptor Superfamily Member 25	22.38	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
11	CALCA	Calcitonin Related Polypeptide Alpha	18.71	GeneCards inferred via : Disorders (show sections)
12	DIO2	Iodothyronine Deiodinase 2	15.14	DISEASES inferred ¹³
13	PTN	Pleiotrophin	13.43	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)

Variations for Toxic Diffuse Goiter

Expression for genes affiliated with Toxic Diffuse Goiter

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

Sources:
³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁶⁰Reactome
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Pathways related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Amine-derived hormones⁶⁰ Show member pathways serotonin and melatonin biosynthesis⁴² Serotonin and melatonin biosynthesis⁶⁰ Thyroxine biosynthesis⁶⁰ Regulation of thyroid hormone activity⁶⁰	9.4	DIO2, TPO
2	Insulin secretion³⁴ Show member pathways Thyroid hormone synthesis³⁴ Aldosterone synthesis and secretion³⁴ Ca2+ activated K+ channels⁶⁰	9.3	SERPINA7, TG, TPO, TSHR
3	Thyroxine (Thyroid Hormone) Production⁴²	9.3	TG, TPO, TRH, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

Sources:
¹⁹Gene Ontology
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Cellular components related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.2	ABCA1, PTN, TNFRSF10B, TPO, TSHR
2	extracellular region	GO:0005576	7.5	C6orf15, CALCA, PTN, SERPINA7, TG, TNFRSF25

Biological processes related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone-mediated signaling pathway	GO:0009755	10.3	TRH, TSHR
2	activation of adenylate cyclase activity	GO:0007190	10.1	CALCA, TSHR
3	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:0007189	10.1	CALCA, TSHR
4	positive regulation of adenylate cyclase activity	GO:0045762	10.0	CALCA, TSHR
5	hormone biosynthetic process	GO:0042446	9.7	DIO2, TG, TPO
6	thyroid hormone generation	GO:0006590	9.6	DIO2, TPO
7	positive regulation of cAMP biosynthetic process	GO:0030819	9.5	ABCA1, CALCA, TSHR
8	thyroid hormone metabolic process	GO:0042403	9.4	DIO2, TG

Molecular functions related to Toxic Diffuse Goiter according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	glycosaminoglycan binding	GO:0005539	10.3	C6orf15, PTN
2	hormone activity	GO:0005179	9.8	CALCA, TG, TRH
3	receptor activity	GO:0004872	9.5	TNFRSF10B, TNFRSF25, TSHR
4	tumor necrosis factor-activated receptor activity	GO:0005031	9.5	TNFRSF10B, TNFRSF25