MCID: TXC004
MIFTS: 31

Toxic Diffuse Goiter malady

Summaries for Toxic Diffuse Goiter

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Insulin secretion and Allograft rejection. The compounds chromium and carbimazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Aliases & Classifications for Toxic Diffuse Goiter

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM
See all sources

Aliases & Descriptions:

toxic diffuse goiter 8 10 44 60


External Ids:

Disease Ontology8 DOID:10719
ICD9CM27 242.00

Related Diseases for Toxic Diffuse Goiter

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Clinical Features for Toxic Diffuse Goiter

About this section

Drugs & Therapeutics for Toxic Diffuse Goiter

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Toxic Diffuse Goiter

Drug clinical trials:

Search ClinicalTrials for Toxic Diffuse Goiter

Search NIH Clinical Center for Toxic Diffuse Goiter

Search CenterWatch for Toxic Diffuse Goiter

Genetic Tests for Toxic Diffuse Goiter

About this section

Anatomical Context for Toxic Diffuse Goiter

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Toxic Diffuse Goiter:

32
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0TG, TPO, TDG, TSHR
2MP:00053787.7TG, TPO, TDG, TSHR

Publications for Toxic Diffuse Goiter

About this section
Sources:
50PubMed
See all sources

Articles related to Toxic Diffuse Goiter:

(show all 31)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
The predictive role of 24h RAIU with respect to the outcome of low fixed dose radioiodine therapy in patients with diffuse toxic goiter. (23422768)
2012
3
Correlation between serum leptin levels and insulin sensitivity in diffuse toxic goiter. (15098916)
2004
4
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
5
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
6
Osteocalcin in diffuse toxic goiter]. (1377070)
1992
7
Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter]. (1658772)
1991
8
The presence of antithyroid antibodies in the blood serum of patients with diffuse toxic goiter before and during treatment]. (2080137)
1990
9
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
10
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
11
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
12
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
13
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
14
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
15
The choice of therapy in toxic diffuse goiter. (80165)
1978
16
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
17
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
18
Functional state of the stomach in patients with diffuse toxic goiter and hypothyroidism]. (1173954)
1975
19
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
20
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
21
Treatment of toxic diffuse goiter. (4183010)
1969
22
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
23
Toxic diffuse goiter in children. (5819609)
1969
24
Induction of myxedema by iodide in patients euthyroid after radioiodin or surgical treatment of diffuse toxic goiter. (4980221)
1969
25
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
26
Chronic treatment of toxic diffuse goiter. (13457490)
1957
27
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
28
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
29
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
30
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
31
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Genetic Variations for Toxic Diffuse Goiter

About this section

Expression for genes affiliated with Toxic Diffuse Goiter

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

About this section
Sources:
29KEGG
See all sources

Pathways related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1TG, TPO
2
Hide members
8.5TG, TPO, TSHR

Compounds for genes affiliated with Toxic Diffuse Goiter

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1chromium4410.3TPO
2carbimazole44 1110.7TPO, TSHR
3amino acid449.7TSHR, TPO
4maltose44 1110.7TSHR, TPO
5asparagine449.6TPO, TSHR
6cytosine44 2410.6TDG, TSHR
7iodotyrosine44 2410.5TG, TPO
8diiodotyrosine449.5TPO, TG
9perchlorate449.5TG, TPO
10gliadin449.5TG, TPO
11amiodarone44 49 28 1112.5TG, TPO
12cardiolipin44 1110.5TPO, TG
13selenium44 2410.4TG, TPO
14adenine44 11 2411.4TDG, TSHR
15sodium dodecylsulfate449.4TG, TPO
16hydrocortisone44 2 59 1112.4TG, TPO
17gold449.3TG, TPO
18prednisolone44 28 1111.3TSHR, TG
19sialic acid449.2TSHR, TG
20agarose449.0TSHR, TPO
21mannose449.0TG, TSHR
22sodium iodide448.9TG, TPO, TSHR
23propylthiouracil44 2 1110.9TG, TPO, TSHR
24iodine44 249.9TSHR, TPO, TG
25carbohydrates448.9TSHR, TG
26125i448.9TG, TPO, TSHR
27iodide44 249.9TSHR, TPO, TG
28methimazole44 2 1110.9TG, TPO, TSHR
29triiodothyronine448.9TG, TPO, TSHR
30thyroxine44 249.9TSHR, TPO, TG
31guanine44 11 2410.9TSHR, TDG, TG
32ribonucleic acid448.9TG, TPO, TSHR
33polysaccharide448.9TG, TPO, TSHR
34sodium44 249.8TG, TPO, TSHR
35aspartate448.8TSHR, TPO, TG
36adenylate448.8TG, TPO, TSHR
37arginine448.8TSHR, TPO, TG
38glutamate448.8TSHR, TPO, TG
39estrogen448.7TG, TDG, TSHR
40retinoic acid44 249.6TSHR, TPO, TG
41cysteine448.5TG, TPO, TSHR

GO Terms for genes affiliated with Toxic Diffuse Goiter

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TG, TPO
2hormone biosynthetic processGO:0424468.8TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Diffuse Goiter

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet