MCID: TXC004
MIFTS: 33

Toxic Diffuse Goiter malady

Endocrine diseases category
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Summaries for Toxic Diffuse Goiter

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33MalaCards
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MalaCards: Toxic Diffuse Goiter is related to goiter and graves' disease. An important gene associated with Toxic Diffuse Goiter is TPO (thyroid peroxidase), and among its related pathways are Allograft rejection and Insulin secretion. The compounds carbimazole and amino acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid and whole blood, and related mouse phenotypes are endocrine/exocrine gland and growth/size/body.

Aliases & Classifications for Toxic Diffuse Goiter

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

toxic diffuse goiter 8 10 45 62


External Ids:

Disease Ontology8 DOID:10719
ICD9CM27 242.00

Related Diseases for Toxic Diffuse Goiter

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Toxic Diffuse Goiter:



Diseases related to toxic diffuse goiter

Symptoms for Toxic Diffuse Goiter

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Drugs & Therapeutics for Toxic Diffuse Goiter

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Toxic Diffuse Goiter

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Anatomical Context for Toxic Diffuse Goiter

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33MalaCards
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MalaCards organs/tissues related to Toxic Diffuse Goiter:

33
Thyroid, Whole blood

Animal Models for Toxic Diffuse Goiter or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Toxic Diffuse Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.5TSHR, TG, TPO
2MP:00053787.9TDG, TSHR, TG, TPO
3MP:00053767.7TPO, TG, TSHR, TDG

Publications for Toxic Diffuse Goiter

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52PubMed
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Articles related to Toxic Diffuse Goiter:

(show all 24)
idTitleAuthorsYear
1
Lead, cadmium, manganese, cobalt, zinc and copper levels in whole blood of urban teenagers with non-toxic diffuse goiter. (21660794)
2012
2
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. (12213665)
2002
3
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
4
Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis. (3413443)
1988
5
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
6
HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. (6131902)
1983
7
Re: simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (6162933)
1981
8
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
9
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
10
The choice of therapy in toxic diffuse goiter. (80165)
1978
11
Iodinating activity of thyroid tissue in toxic diffuse goiter. (576614)
1977
12
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
13
I-131 treatment for toxic diffuse goiter. Analysis of 1056 cured cases. (4665962)
1972
14
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
15
Treatment of toxic diffuse goiter. (4183010)
1969
16
I131 treatment for toxic diffuse goiter: analysis of 1056 cured cases. (5257435)
1969
17
Toxic diffuse goiter in children. (5819609)
1969
18
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
19
Chronic treatment of toxic diffuse goiter. (13457490)
1957
20
Short-term goitrogen therapy of toxic diffuse goiter complicating pregnancy. (14929372)
1952
21
Treatment of toxic diffuse goiter (Graves's disease) in childhood; report of a case successfully treated with propylthiouracil. (14810187)
1951
22
Observations on the prolonged medical management of toxic diffuse goiter with thiouracil and propylthiouracil. (14771065)
1950
23
Problem cases of toxic diffuse goiter treated with radioactive iodine. (18146931)
1949
24
The use of intravenous iodine in preparing the patient with toxic diffuse goiter for operation. (21002593)
1946

Variations for Toxic Diffuse Goiter

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Expression for genes affiliated with Toxic Diffuse Goiter

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Diffuse Goiter

Search GEO for disease gene expression data for Toxic Diffuse Goiter.

Pathways for genes affiliated with Toxic Diffuse Goiter

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Toxic Diffuse Goiter

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1carbimazole45 1110.7TSHR, TPO
2amino acid459.7TPO, TSHR
3maltose45 1110.7TPO, TSHR
4asparagine459.7TPO, TSHR
5cytosine45 2410.7TDG, TSHR
6iodotyrosine45 2410.6TG, TPO
7diiodotyrosine459.6TG, TPO
8perchlorate459.5TG, TPO
9adenine45 24 1111.5TSHR, TDG
10gliadin459.5TG, TPO
11chromium459.5TPO, TG
12amiodarone45 51 29 1112.5TG, TPO
13cardiolipin45 1110.5TG, TPO
14selenium45 2410.5TPO, TG
15agarose459.5TSHR, TPO
16sodium dodecylsulfate459.4TG, TPO
17acth459.4TSHR, TPO
18hydrocortisone45 3 61 1112.4TG, TPO
19gold459.4TG, TPO
20prednisolone45 29 1111.3TSHR, TG
21sialic acid459.3TSHR, TG
22histidine459.2TPO, TSHR
23carbohydrates459.2TSHR, TG
24mannose459.1TG, TSHR
25ascorbic acid45 2410.1TG, TPO
2612-o-tetradecanoylphorbol 13-acetate459.0TPO, TSHR
27sodium iodide459.0TSHR, TG, TPO
28propylthiouracil45 3 1111.0TSHR, TG, TPO
29iodine45 249.9TPO, TG, TSHR
30125i458.9TSHR, TG, TPO
31iodide45 249.9TPO, TG, TSHR
32methimazole45 3 1110.9TSHR, TG, TPO
33triiodothyronine458.9TPO, TG, TSHR
34thyroxine45 249.9TPO, TG, TSHR
35guanine45 24 1110.9TG, TSHR, TDG
36ribonucleic acid458.9TSHR, TG, TPO
37polysaccharide458.9TSHR, TG, TPO
38sodium45 249.9TSHR, TG, TPO
39aspartate458.9TPO, TG, TSHR
40adenylate458.9TSHR, TG, TPO
41arginine458.9TSHR, TG, TPO
42glutamate458.8TSHR, TG, TPO
43estrogen458.8TG, TSHR, TDG
44retinoic acid45 249.8TSHR, TG, TPO
45cysteine458.8TPO, TG, TSHR
46tyrosine458.5TSHR, TG, TPO

GO Terms for genes affiliated with Toxic Diffuse Goiter

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16Gene Ontology
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Biological processes related to Toxic Diffuse Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.1TG, TPO
2hormone biosynthetic processGO:0424468.8TG, TPO

Products for genes affiliated with Toxic Diffuse Goiter

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  • Antibodies
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Sources for Toxic Diffuse Goiter

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet