MCID: TXC002
MIFTS: 45

Toxic Encephalopathy malady

Neuronal category

Summaries for Toxic Encephalopathy

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.

MalaCards: Toxic Encephalopathy, also known as neurotoxicity, is related to alzheimer's disease and parkinson's disease. An important gene associated with Toxic Encephalopathy is CYP2D7P1 (cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1), and among its related pathways are Pathogenesis of ALS and Neuroscience. The compounds Glutathione and nadph have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum, and related mouse phenotype behavior/neurological.

Wikipedia:64 Chronic solvent encephalopathy is a degenerative neurologic disorder caused by exposure to toxic... more...

Aliases & Classifications for Toxic Encephalopathy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 44NINDS, 35MeSH, 57SNOMED-CT, 40NCIt, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

toxic encephalopathy 8 43 10
neurotoxicity 8 44
neurotoxicity syndromes 43
neurotoxicity syndrome 8


External Ids:

Disease Ontology8 DOID:3602
MeSH35 D020258
SNOMED-CT57 19466003
NCIt40 C27961
ICD1025 G92

Related Diseases for Toxic Encephalopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Toxic Encephalopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.6CA4, CALB1, PDYN, NEFM, NEFH, DECR1
2parkinson's disease30.4CALB1, PDYN, CDK5R1, GSTA4
3amyotrophic lateral sclerosis30.4NEFH, NEFM
4memory impairment30.3CDK5R1, PDYN, CALB1
5chronic pain10.4
6lateral sclerosis10.3
7brain disease10.2
8lathyrism10.2
9shigellosis10.1
10pheochromocytoma10.1
11status epilepticus10.0
12subacute leukemia10.0
13aseptic meningitis10.0
14phenylketonuria10.0
15cocaine abuse10.0
16fetal alcohol syndrome10.0
17dihydropyrimidine dehydrogenase deficiency10.0
18astrocytoma10.0
19tauopathy10.0
20tooth disease10.0
21dementia, familial danish10.0
22brain injury10.0
23neuroblastoma 110.0
24drug addiction10.0
25venous thrombosis10.0
26brain ischemia10.0
27multiple chemical sensitivity10.0
28neuroleptic malignant syndrome10.0
29n syndrome10.0
30acute leukemia10.0
31tinea capitis10.0
32whiplash10.0
33prion disease10.0CALB1, GPX5, GPX4
34schizophrenia10.0CA4, CALB1, PDYN, GRIN2C, CYP2D7P1, PLA2G1B
35cork-handlers' disease10.0DECR1, GPX5, GPX4, PLA2G1B
36lung cancer10.0GSTA3, GSTA4, GSTA2, CYP2D7P1
37vascular disease10.0CA4, GPX5, GPX4, GSTA2, GSTA4, GSTA3
38congenital heart defect10.0PLA2G1B, GPX4, GPX5, DECR1
39bladder carcinoma in situ10.0GSTA2, GSTA4, GSTA3
40galactosemia10.0CYP2D7P1, GPX5, GPX4, GSTA2, GSTA4, GSTA3
41ischemia10.0PDYN, CDK5R1, PLA2G1B
42keshan disease10.0GPX4, GPX5
43schistosomiasis10.0GSTA3, GSTA4, GSTA2
44motor neuron disease10.0NEFH
45neuropathy10.0NEFH, NEFM
46primary pulmonary hypertension9.9
47axonal neuropathy9.9
48vascular dementia9.9
49wernicke-korsakoff syndrome9.9
50alcohol abuse9.9

Graphical network of the top 20 diseases related to Toxic Encephalopathy:



Diseases related to toxic encephalopathy

Clinical Features for Toxic Encephalopathy

Drugs & Therapeutics for Toxic Encephalopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Toxic Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Toxic Encephalopathy

Search NIH Clinical Center for Toxic Encephalopathy

Search CenterWatch for Toxic Encephalopathy

Genetic Tests for Toxic Encephalopathy

Anatomical Context for Toxic Encephalopathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Toxic Encephalopathy:

33
Brain, Cerebellum

Animal Models for Toxic Encephalopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Toxic Encephalopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5GSTA3, PDYN, NEFM, NEFH, DECR1, SYN1

Publications for Toxic Encephalopathy

Sources:
51PubMed
See all sources

Articles related to Toxic Encephalopathy:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
MRI brain in monohalomethane toxic encephalopathy: A case report. (24347845)
2013
2
L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia. (23961306)
2013
3
Establishment of a poisoned animal model of toxic encephalopathy induced by 1,2-dichloroethane. (21329570)
2011
4
Toxic encephalopathy. (21590623)
2011
5
Toxic encephalopathy after taking dried seeds of Datura stramonium in two elderly subjects. (19702945)
2009
6
High imipenem blood concentrations associated with toxic encephalopathy in a patient with mild renal dysfunction. (19596561)
2009
7
Margosa (Kohomba) oil induced toxic encephalopathy following home remedy for intestinal worms. (20052860)
2009
8
Acute toxic encephalopathy due to the ingestion of Rhus extract. (19570681)
2009
9
An unusual case of 4-aminopyridine toxicity in a multiple sclerosis patient: epileptic disorder or toxic encephalopathy? (19402572)
2009
10
Toxic encephalopathy and delayed MTX clearance after high-dose methotrexate therapy in a child homozygous for the MTHFR C677T polymorphism. (19031955)
2008
11
Visual search and eye movements in patients with chronic solvent-induced toxic encephalopathy. (16765447)
2006
12
Toxic encephalopathy and noise-induced hearing loss. (17851218)
2006
13
Psychological distress and coping in women married to men with a diagnosis of solvent-induced chronic toxic encephalopathy. (16101264)
2005
14
Solvent-related chronic toxic encephalopathy as a target in the worker's mental health research. (15558155)
2004
15
Toxic encephalopathy induced by capecitabine. (15218302)
2004
16
Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. (11339626)
2001
17
Evaluation of blink reflex results obtained from workers previously diagnosed with solvent-induced toxic encephalopathy. (11515255)
2001
18
Organic solvent induced chronic toxic encephalopathy: extent of recovery, and associated factors, following cessation of exposure. (11130269)
2000
19
Stress management in men with solvent-induced chronic toxic encephalopathy. (10874661)
2000
20
Influence of personality traits on neuropsychological test performance in toxic encephalopathy cases and healthy referent subjects. (11130270)
2000
21
Absence of polyneuropathy among workers previously diagnosed with solvent-induced toxic encephalopathy. (10390702)
1999
22
Trail making test in chronic toxic encephalopathy: performance and discriminative potential. (10726603)
1999
23
Long-term follow-up of psychological distress, social functioning, and coping style in treated and untreated patients with solvent-induced chronic toxic encephalopathy. (9777564)
1998
24
Solvent-induced toxic encephalopathy: electrophysiological data in relation to neuropsychological findings. (9408804)
1997
25
Toxic shock syndrome without rash in a young child: link with syndrome of hemorrhagic shock and encephalopathy? (9255204)
1997
26
Neuropsychological deficits in patients diagnosed with chronic toxic encephalopathy: which tests are most discriminative? (16318505)
1996
27
Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. (8923609)
1996
28
Toxic encephalopathy due to 1,1,1-trichloroethane exposure. (7605490)
1995
29
Contrast sensitivity in organic-solvent-induced chronic toxic encephalopathy. (8749741)
1995
30
Toxic encephalopathy due to 1,1,1-trichloroethane. (8331433)
1993
31
Three-dimensional brain metabolic imaging in patients with toxic encephalopathy. (8472660)
1993
32
Toxic encephalopathy. (1348902)
1992
33
Power spectrum analysis of EEG at diagnosis and follow up of patients with solvent induced chronic toxic encephalopathy. (3395583)
1988
34
Computed tomography and psychometric test performances in patients with solvent induced chronic toxic encephalopathy and healthy controls. (3828243)
1987
35
Chronic toxic encephalopathy in solvent-exposed painters in Denmark 1976-1980: clinical cases and social consequences after a 5-year follow-up. (3578293)
1987
36
Acute toxic encephalopathy secondary to bromide sedative ingestion. (3587599)
1987
37
Brain-stem response audiometry and electronystagmographic findings in chronic toxic encephalopathy (chronic painter's syndrome). (3950476)
1986
38
Acute toxic encephalopathy with symmetrical low density areas in the thalami and the cerebellum. (3872716)
1985
39
Isoniazid-induced acute toxic encephalopathy. (6538670)
1984
40
Chronic toxic encephalopathy in house-painters. (6588707)
1984
41
Cerebral blood flow in chronic toxic encephalopathy in house painters exposed to organic solvents. (7113678)
1982
42
Periventricular localization of a toxic encephalopathy induced by a mechanism involving choroid plexus. (6981447)
1982
43
Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy. (7315195)
1981
44
Chronic painters' syndrome. Chronic toxic encephalopathy in house painters. (517113)
1979
45
Toxic encephalopathy from chlorobenzilate poisoning: report of a case. (737852)
1978
46
Toxic encephalopathy with hippocampal lesions. (99916)
1978
47
Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication. (623061)
1978
48
Acute brain swelling (toxic encephalopathy). (4875463)
1967
49
Toxic encephalopathy occurring during topical therapy with asterol; report of two cases. (12990336)
1952
50
Acute toxic encephalopathy of unknown aetiology in two brothers. (18100587)
1948

Genetic Variations for Toxic Encephalopathy

Expression for genes affiliated with Toxic Encephalopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Toxic Encephalopathy

Search GEO for disease gene expression data for Toxic Encephalopathy.

Pathways for genes affiliated with Toxic Encephalopathy

Sources:
52QIAGEN, 30KEGG, 4Cell Signaling Technology, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Toxic Encephalopathy

Sources:
11DrugBank, 24HMDB, 45Novoseek, 29IUPHAR
See all sources

Compounds related to Toxic Encephalopathy according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1Glutathione11 2411.7GSTA3, GSTA4, GSTA2, GPX4, GPX5
2nadph45 2411.7CALB1, NDOR1, DECR1, CYP3A43, GPX5, GPX4
3noradrenochrome45 2411.7GSTA2, GSTA4, GSTA3
4hydrochloric acid45 2411.7GSTA3, GSTA4, GSTA2
5adrenochrome45 2411.7GSTA2, GSTA4, GSTA3
65-hpete45 2411.6GPX4, GPX5
7phospholipid4510.6CA4, PDYN, GPX4, PLA2G1B
8kainate45 2911.5GRIN2C, PDYN, CALB1
9oligonucleotide4510.5CALB1, PDYN, NEFM, CDK5R1, GPX4
10lipid4510.5SYCN, GPX5, GPX4, PLA2G1B, GSTA4, PDYN
11sulfate45 2411.4GSTA2, GSTA4, GSTA3
12potassium45 11 2412.2PLA2G1B, PDYN, NDOR1, CALB1

GO Terms for genes affiliated with Toxic Encephalopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5NDOR1, SYN1, CDK5R1, GPX4, GSTA2, GSTA4
2axonGO:03042410.5CDK5R1, NEFH, NEFM, CALB1
3neurofilamentGO:00588310.4NEFM, NEFH
4secretory granule membraneGO:03066710.2SYCN, CA4

Biological processes related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428110.6GSTA3, CA4, NDOR1, NDUFB11, DECR1, CYP3A43
2glutathione derivative biosynthetic processGO:190168710.5GSTA2, GSTA4, GSTA3
3neurofilament cytoskeleton organizationGO:06005210.5NEFH, NEFM
4glutathione metabolic processGO:00674910.5GSTA3, GSTA4, GSTA2
5xenobiotic metabolic processGO:00680510.4CYP3A43, GSTA2, GSTA4, GSTA3
6intermediate filament bundle assemblyGO:04511010.2NEFH, NEFM

Molecular functions related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione peroxidase activityGO:00460210.5GPX4, GPX5
2glutathione transferase activityGO:00436410.2GSTA3, GSTA4, GSTA2

Products for genes affiliated with Toxic Encephalopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Encephalopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet