MCID: TXC002
MIFTS: 48

Toxic Encephalopathy malady

Neuronal diseases category

Summaries for Toxic Encephalopathy

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.

MalaCards: Toxic Encephalopathy, also known as neurotoxicity, is related to alzheimer's disease and parkinson's disease. An important gene associated with Toxic Encephalopathy is CYP2D7P1 (cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1), and among its related pathways are Pathogenesis of ALS and Neuroscience. The compounds Glutathione and nadph have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotype behavior/neurological.

Wikipedia:63 Chronic solvent encephalopathy is a degenerative neurologic disorder caused by exposure to toxic... more...

Aliases & Classifications for Toxic Encephalopathy

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 43NINDS, 34MeSH, 56SNOMED-CT, 39NCIt, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

toxic encephalopathy 8 42 10
neurotoxicity 8 43
neurotoxicity syndromes 42
neurotoxicity syndrome 8


External Ids:

Disease Ontology8 DOID:3602
MeSH34 D020258
SNOMED-CT56 19466003
NCIt39 C27961
ICD1025 G92

Related Diseases for Toxic Encephalopathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Toxic Encephalopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.8CA4, CALB1, PDYN, NEFM, NEFH, DECR1
2parkinson's disease30.6CALB1, PDYN, CDK5R1, GSTA4
3neuropathy30.5NEFH, NEFM
4amyotrophic lateral sclerosis30.3NEFH, NEFM
5ischemia30.3PDYN, CDK5R1, PLA2G1B
6prion disease30.2CALB1, GPX5, GPX4
7motor neuron disease29.7NEFH
8neuronitis10.8
9neuroblastoma10.5
10lateral sclerosis10.2
11cerebritis10.1
12shigellosis10.1
13huntington's disease10.1
14differentiating neuroblastoma10.1
15brain disease10.1
16hepatitis10.1
17hereditary sensory neuropathy10.1
18meningitis10.1
19retinitis10.1
20pheochromocytoma10.1
21schizophrenia10.0CA4, CALB1, PDYN, GRIN2C, CYP2D7P1, PLA2G1B
22cork-handlers' disease10.0DECR1, GPX5, GPX4, PLA2G1B
23lung cancer10.0GSTA3, GSTA4, GSTA2, CYP2D7P1
24vascular disease10.0CA4, GPX5, GPX4, GSTA2, GSTA4, GSTA3
25congenital heart defect10.0PLA2G1B, GPX4, GPX5, DECR1
26memory impairment10.0CDK5R1, PDYN, CALB1
27bladder carcinoma in situ10.0GSTA2, GSTA4, GSTA3
28galactosemia10.0CYP2D7P1, GPX5, GPX4, GSTA2, GSTA4, GSTA3
29keshan disease10.0GPX4, GPX5
30schistosomiasis10.0GSTA3, GSTA4, GSTA2
31multiple chemical sensitivity10.0
32choroiditis10.0
33neuroleptic malignant syndrome10.0
34acute leukemia10.0
35cervicitis10.0
36dementia10.0
37lactic acidosis10.0
38leukemia10.0
39lymphoblastic leukemia10.0
40multiple sclerosis10.0
41pneumonia10.0
42polyneuropathy10.0
43tinea capitis10.0
44status epilepticus10.0
45subacute leukemia10.0
46aseptic meningitis10.0
47phenylketonuria10.0
48end stage renal failure10.0
49cocaine abuse10.0
50fetal alcohol syndrome10.0

Graphical network of the top 20 diseases related to Toxic Encephalopathy:



Diseases related to toxic encephalopathy

Clinical Features for Toxic Encephalopathy

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Drugs & Therapeutics for Toxic Encephalopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Toxic Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Toxic Encephalopathy

Search NIH Clinical Center for Toxic Encephalopathy

Search CenterWatch for Toxic Encephalopathy

Genetic Tests for Toxic Encephalopathy

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Anatomical Context for Toxic Encephalopathy

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Sources:
32MalaCards
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MalaCards organs/tissues related to Toxic Encephalopathy:

32
Brain, Testes, Eye, Cerebellum

Animal Models for Toxic Encephalopathy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Toxic Encephalopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5GSTA3, PDYN, NEFM, NEFH, DECR1, SYN1

Publications for Toxic Encephalopathy

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Sources:
50PubMed
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Articles related to Toxic Encephalopathy:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia. (23961306)
2013
2
Toxic encephalopathy. (23251840)
2012
3
Toxic encephalopathy caused by occupational exposure to 1, 2-Dichloroethane. (20163807)
2010
4
Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy. (19136963)
2009
5
An unusual case of 4-aminopyridine toxicity in a multiple sclerosis patient: epileptic disorder or toxic encephalopathy? (19402572)
2009
6
Psychosocial and cognitive rehabilitation of patients with solvent-induced chronic toxic encephalopathy: a randomised controlled study. (18560254)
2008
7
Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. (17046301)
2007
8
Visual search and eye movements in patients with chronic solvent-induced toxic encephalopathy. (16765447)
2006
9
Toxic encephalopathy and noise-induced hearing loss. (17851218)
2006
10
Education for men with solvent-induced chronic toxic encephalopathy and their spouses. (15950841)
2005
11
Psychological distress and coping in women married to men with a diagnosis of solvent-induced chronic toxic encephalopathy. (16101264)
2005
12
Suboptimal performance on neuropsychological tests in patients with suspected chronic toxic encephalopathy. (12900068)
2003
13
Interaction between smoking and glutathione S-transferase polymorphisms in solvent-induced chronic toxic encephalopathy. (14992466)
2002
14
Solvent-induced toxic encephalopathy. (12024683)
2002
15
Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. (11339626)
2001
16
Organic solvent induced chronic toxic encephalopathy: extent of recovery, and associated factors, following cessation of exposure. (11130269)
2000
17
Psychological test performance during experimental challenge to toluene and n-butyl acetate in cases of solvent-induced toxic encephalopathy. (10901114)
2000
18
Criteria for solvent-induced chronic toxic encephalopathy: a systematic review. (11007338)
2000
19
A comparison of neuropsychological tests for the assessment of chronic toxic encephalopathy. (11071689)
2000
20
Influence of personality traits on neuropsychological test performance in toxic encephalopathy cases and healthy referent subjects. (11130270)
2000
21
Chronic toxic encephalopathy in a painter exposed to mixed solvents. (10210698)
1999
22
Encephalopathy, lactic acidosis, hyperammonaemia and 5-fluorouracil toxicity. (9635854)
1998
23
Long-term follow-up of psychological distress, social functioning, and coping style in treated and untreated patients with solvent-induced chronic toxic encephalopathy. (9777564)
1998
24
Possible toxic encephalopathy following high-dose intravenous haloperidol. (9184715)
1997
25
Solvent-induced toxic encephalopathy: electrophysiological data in relation to neuropsychological findings. (9408804)
1997
26
Toxic encephalopathy due to 1,1,1-trichloroethane exposure. (7605490)
1995
27
Toxic encephalopathy due to 1,1,1-trichloroethane exposure. (8160661)
1994
28
Three-dimensional brain metabolic imaging in patients with toxic encephalopathy. (8472660)
1993
29
Toxic encephalopathy. (1348902)
1992
30
Power spectrum analysis of EEG at diagnosis and follow up of patients with solvent induced chronic toxic encephalopathy. (3395583)
1988
31
Computed tomography and psychometric test performances in patients with solvent induced chronic toxic encephalopathy and healthy controls. (3828243)
1987
32
Acute toxic encephalopathy secondary to bromide sedative ingestion. (3587599)
1987
33
Neuropsychological assessment of toxic encephalopathy. (3578292)
1987
34
Toxic encephalopathy in a child after brief exposure to insect repellents. (3965068)
1985
35
Acute toxic encephalopathy with symmetrical low density areas in the thalami and the cerebellum. (3872716)
1985
36
Isoniazid-induced acute toxic encephalopathy. (6538670)
1984
37
Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy. (7315195)
1981
38
Epileptic phenomena in bismuth toxic encephalopathy. (7205307)
1981
39
Nonaphasic misnaming and other neurobehavioral features of an unusual toxic encephalopathy: case study. (7471772)
1980
40
Chronic painters' syndrome. Chronic toxic encephalopathy in house painters. (517113)
1979
41
Toxic encephalopathy from chlorobenzilate poisoning: report of a case. (737852)
1978
42
Toxic encephalopathy with hippocampal lesions. (99916)
1978
43
Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication. (623061)
1978
44
Toxic encephalopathy due to ingestion of bismuth salts: clinical and EEG studies of 45 patients. (336849)
1977
45
Toxic encephalopathy and acute brain-swelling in children. (1102371)
1975
46
Toxic encephalopathy with seizures secondary to ingestion of composition C-4. A clinical and electroencephalographic study. (4673417)
1972
47
Acute brain swelling (toxic encephalopathy). (4875463)
1967
48
Toxic encephalopathy caused by stalinon; anatomoclinical & EEG aspects]. (13649271)
1959
49
Toxic encephalopathy occurring during topical therapy with asterol; report of two cases. (12990336)
1952
50
Acute toxic encephalopathy of unknown aetiology in two brothers. (18100587)
1948

Genetic Variations for Toxic Encephalopathy

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Expression for genes affiliated with Toxic Encephalopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Encephalopathy

Search GEO for disease gene expression data for Toxic Encephalopathy.

Pathways for genes affiliated with Toxic Encephalopathy

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Sources:
51QIAGEN, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Toxic Encephalopathy

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Sources:
11DrugBank, 24HMDB, 44Novoseek, 28IUPHAR
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Compounds related to Toxic Encephalopathy according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1Glutathione11 2411.7GSTA3, GSTA4, GSTA2, GPX4, GPX5
2nadph44 2411.7CALB1, NDOR1, DECR1, CYP3A43, GPX5, GPX4
3noradrenochrome44 2411.7GSTA2, GSTA4, GSTA3
4hydrochloric acid44 2411.7GSTA3, GSTA4, GSTA2
5adrenochrome44 2411.7GSTA2, GSTA4, GSTA3
65-hpete44 2411.6GPX4, GPX5
7phospholipid4410.6CA4, PDYN, GPX4, PLA2G1B
8kainate44 2811.5GRIN2C, PDYN, CALB1
9oligonucleotide4410.5CALB1, PDYN, NEFM, CDK5R1, GPX4
10lipid4410.5SYCN, GPX5, GPX4, PLA2G1B, GSTA4, PDYN
11sulfate44 2411.4GSTA2, GSTA4, GSTA3
12potassium44 11 2412.2PLA2G1B, PDYN, NDOR1, CALB1

GO Terms for genes affiliated with Toxic Encephalopathy

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16Gene Ontology
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Cellular components related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5NDOR1, SYN1, CDK5R1, GPX4, GSTA2, GSTA4
2axonGO:03042410.5CDK5R1, NEFH, NEFM, CALB1
3neurofilamentGO:00588310.4NEFM, NEFH
4secretory granule membraneGO:03066710.2SYCN, CA4

Biological processes related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428110.6GSTA3, CA4, NDOR1, NDUFB11, DECR1, CYP3A43
2glutathione derivative biosynthetic processGO:190168710.5GSTA2, GSTA4, GSTA3
3neurofilament cytoskeleton organizationGO:06005210.5NEFH, NEFM
4glutathione metabolic processGO:00674910.5GSTA3, GSTA4, GSTA2
5xenobiotic metabolic processGO:00680510.4CYP3A43, GSTA2, GSTA4, GSTA3
6intermediate filament bundle assemblyGO:04511010.2NEFH, NEFM

Molecular functions related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione peroxidase activityGO:00460210.5GPX4, GPX5
2glutathione transferase activityGO:00436410.2GSTA3, GSTA4, GSTA2

Products for genes affiliated with Toxic Encephalopathy

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  • Antibodies
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Sources for Toxic Encephalopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet