MCID: TXC002
MIFTS: 49

Toxic Encephalopathy malady

Rare diseases, Neuronal diseases categories

Summaries for Toxic Encephalopathy

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.

MalaCards: Toxic Encephalopathy, also known as neurotoxicity, is related to alzheimer's disease and neuropathy. An important gene associated with Toxic Encephalopathy is GSTA3 (glutathione S-transferase alpha 3), and among its related pathways are Cytoplasmic microtubules and Nicotine addiction. The compounds ethacrynic acid and busulfan have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:66 Chronic solvent encephalopathy is a degenerative neurologic disorder caused by exposure to toxic... more...

Aliases & Classifications for Toxic Encephalopathy

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9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 41NCIt, 36MeSH, 59SNOMED-CT, 63UMLS, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

toxic encephalopathy 9 44 11
neurotoxicity 9 45
neurotoxicity syndromes 44
neurotoxicity syndrome 9


External Ids:

Disease Ontology9 DOID:3602
NCIt41 C27961
SNOMED-CT59 19466003
MeSH36 D020258
ICD1026 G92

Related Diseases for Toxic Encephalopathy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Toxic Encephalopathy:



Diseases related to toxic encephalopathy

Symptoms for Toxic Encephalopathy

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Drugs & Therapeutics for Toxic Encephalopathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Toxic Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Toxic Encephalopathy

Search NIH Clinical Center for Toxic Encephalopathy

Search CenterWatch for Toxic Encephalopathy

Genetic Tests for Toxic Encephalopathy

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Anatomical Context for Toxic Encephalopathy

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34MalaCards
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MalaCards organs/tissues related to Toxic Encephalopathy:

34
Brain, Testes, Eye, Cerebellum

Animal Models for Toxic Encephalopathy or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Toxic Encephalopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2GRIN2C, CHRNA4, NEFM, NEFH, GPX4
2MP:00053867.6GRIN2C, GPX4, NEFH, NEFM, CHRNA4, GSTA3

Publications for Toxic Encephalopathy

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Sources:
53PubMed
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Articles related to Toxic Encephalopathy:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Ethylene glycol toxic encephalopathy. (24347968)
2013
2
MRI brain in monohalomethane toxic encephalopathy: A case report. (24347845)
2013
3
Toxic encephalopathy. (22362126)
2012
4
Toxic encephalopathy in elderly patients during treatment with capecitabine: literature review and a case report. (20926454)
2011
5
Toxic encephalopathy caused by occupational exposure to 1, 2-Dichloroethane. (20163807)
2010
6
Toxic encephalopathy after taking dried seeds of Datura stramonium in two elderly subjects. (19702945)
2009
7
High imipenem blood concentrations associated with toxic encephalopathy in a patient with mild renal dysfunction. (19596561)
2009
8
Toxic encephalopathy and delayed MTX clearance after high-dose methotrexate therapy in a child homozygous for the MTHFR C677T polymorphism. (19031955)
2008
9
Neuroleptic malignant syndrome due to amisulpride in a patient with solvent-induced chronic toxic encephalopathy. (17762322)
2007
10
Visual search and eye movements in patients with chronic solvent-induced toxic encephalopathy. (16765447)
2006
11
Methadone intoxication in a child: toxic encephalopathy? (16970857)
2006
12
Solvent-related chronic toxic encephalopathy as a target in the worker's mental health research. (15558155)
2004
13
Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash. (12920327)
2003
14
Interaction between smoking and glutathione S-transferase polymorphisms in solvent-induced chronic toxic encephalopathy. (14992466)
2002
15
Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. (11339626)
2001
16
Organic solvent induced chronic toxic encephalopathy: extent of recovery, and associated factors, following cessation of exposure. (11130269)
2000
17
Stress management in men with solvent-induced chronic toxic encephalopathy. (10874661)
2000
18
Psychological test performance during experimental challenge to toluene and n-butyl acetate in cases of solvent-induced toxic encephalopathy. (10901114)
2000
19
Criteria for solvent-induced chronic toxic encephalopathy: a systematic review. (11007338)
2000
20
Chronic toxic encephalopathy in a painter exposed to mixed solvents. (10210698)
1999
21
Absence of polyneuropathy among workers previously diagnosed with solvent-induced toxic encephalopathy. (10390702)
1999
22
Possible toxic encephalopathy following high-dose intravenous haloperidol. (9184715)
1997
23
Neuropsychological deficits in patients diagnosed with chronic toxic encephalopathy: which tests are most discriminative? (16318505)
1996
24
Glutathione S-transferase M1 null genotype as a risk modifier for solvent-induced chronic toxic encephalopathy. (8923609)
1996
25
Toxic encephalopathy due to 1,1,1-trichloroethane exposure. (7605490)
1995
26
Toxic encephalopathy due to 1,1,1-trichloroethane. (8331433)
1993
27
Magnetic resonance imaging (MRI), neurobehavioral testing, and toxic encephalopathy: two cases. (8472665)
1993
28
Toxic encephalopathy. (1348902)
1992
29
Magnetic resonance imaging in toxic encephalopathy due to podophyllin poisoning. (1922761)
1991
30
Chronic toxic encephalopathy investigated using dynamic posturography. (1858979)
1991
31
Cerebrospinal fluid proteins and free amino acids in patients with solvent induced chronic toxic encephalopathy and healthy controls. (2337535)
1990
32
Margosa oil poisoning as a cause of toxic encephalopathy. (2259944)
1990
33
Chronic toxic encephalopathy among house painters with disability pension. (2528611)
1989
34
Computed tomography in patients with dementia probably due to toxic encephalopathy. (3408614)
1988
35
Prospective clinical and psychometric investigation of patients with chronic toxic encephalopathy induced by solvents. (3353695)
1988
36
Computed tomography and psychometric test performances in patients with solvent induced chronic toxic encephalopathy and healthy controls. (3828243)
1987
37
Toxic encephalopathy caused by topically applied diphenhydramine. (3712143)
1986
38
Toxic encephalopathy in a child after brief exposure to insect repellents. (3965068)
1985
39
Acute toxic encephalopathy with symmetrical low density areas in the thalami and the cerebellum. (3872716)
1985
40
Acute fulminant toxic encephalopathy associated with Mycoplasma pneumoniae infection. (4022808)
1985
41
Isoniazid-induced acute toxic encephalopathy. (6538670)
1984
42
Chronic toxic encephalopathy in house-painters. (6588707)
1984
43
Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy. (7315195)
1981
44
Toxic encephalopathy with hyperammonaemia during high-dose salicylate therapy. (7395459)
1980
45
Toxic encephalopathy from chlorobenzilate poisoning: report of a case. (737852)
1978
46
Toxic encephalopathy and acute brain-swelling in children. (1102371)
1975
47
Proceedings: Toxic encephalopathy with seizures secondary to ingestion of an explosive material: Composition C-4. A clinical and electroencephalographic study. (4680342)
1972
48
Toxic encephalopathy apparently related to the use of an insect repellent. (13709286)
1961
49
Toxic encephalopathy occurring during topical treatment for tinea capitis. (13109603)
1953
50
Toxic encephalopathy occurring during topical therapy with asterol; report of two cases. (12990336)
1952

Variations for Toxic Encephalopathy

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Expression for genes affiliated with Toxic Encephalopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Encephalopathy

Search GEO for disease gene expression data for Toxic Encephalopathy.

Pathways for genes affiliated with Toxic Encephalopathy

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Sources:
51PathCards, 13EMD Millipore, 61Thomson Reuters, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome
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Pathways related to Toxic Encephalopathy according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.6NEFH, NEFM
29.6GRIN2C, CHRNA4
39.6GRIN2C, CHRNA4
4
Show member pathways
AhR pathway39
9.5GSTA1, GSTA2
5
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.5GSTA2, GSTA1
6
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.3NEFM, NEFH, GRIN2C
79.2GSTA1, GSTA2, GSTA3
88.7GSTA2, GSTT1, GSTA1
9
Show member pathways
8.3GSTA2, GSTT1, GSTA3, GSTA1
10
Show member pathways
7.8GPX4, GSTA2, GSTT1, GSTA3, GSTA1
11
Show member pathways
7.8GSTA3, GSTA1, GSTT1, GPX4, GSTA2
12
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
7.8GSTA2, GPX4, GSTT1, GSTA3, GSTA1

Compounds for genes affiliated with Toxic Encephalopathy

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Toxic Encephalopathy according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1ethacrynic acid46 1210.7GSTA1, GSTA2
2busulfan46 52 1211.7GSTA2, GSTA1
3cumene hydroperoxide469.4GSTT1, GPX4
4phenobarbital46 30 52 1212.3GSTA1, CHRNA4
5manganese superoxide469.2GSTT1, GPX4
6superoxide46 2510.2NEFM, NEFH, GPX4
7aflatoxin b146 2510.2GSTA1, GSTT1
8malondialdehyde469.2GPX4, GSTT1
9azathioprine46 3 52 1212.2GSTA2, GSTA1
10vitamin-e469.0GSTT1, GPX4
11gsts468.9GSTA1, GSTT1, GSTA2
12Estrone-2,3-quinone258.7GSTA2, GSTT1, GSTA3, GSTA1
134-Hydroxyestrone-2-S-glutathione258.7GSTA2, GSTT1, GSTA3, GSTA1
14Estrone-3,4-quinone258.7GSTA1, GSTA3, GSTT1, GSTA2
15oligonucleotide468.7GSTT1, NEFM, GPX4
16S-(PGJ2)-glutathione258.7GSTA1, GSTA3, GSTT1, GSTA2
17noradrenochrome46 259.7GSTA1, GSTA3, GSTT1, GSTA2
182-Hydroxyestrone-1-S-glutathione258.7GSTA1, GSTA3, GSTT1, GSTA2
192-Hydroxyestrone-4-S-glutathione258.6GSTA1, GSTA3, GSTT1, GSTA2
20hydrochloric acid46 259.6GSTA2, GSTT1, GSTA3, GSTA1
21adrenochrome46 259.6GSTA2, GSTT1, GSTA3, GSTA1
22sulfate46 259.6GSTA2, GSTT1, GSTA3, GSTA1
23Glutathione25 129.2GSTA1, GSTA3, GSTT1, GSTA2, GPX4
24Water258.1GPX4, GSTA2, GSTT1, GSTA3, GSTA1

GO Terms for genes affiliated with Toxic Encephalopathy

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17Gene Ontology
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Cellular components related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofibrillary tangleGO:0974189.5NEFM, NEFH
2neurofilamentGO:0058839.3NEFM, NEFH
3cytosolGO:0058297.8GSTA1, GSTA3, GSTT1, GSTA2, GPX4

Biological processes related to Toxic Encephalopathy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1neurofilament bundle assemblyGO:0336939.6NEFM, NEFH
2epithelial cell differentiationGO:0308559.5GSTA1, GSTA2
3microtubule cytoskeleton organizationGO:0002269.3NEFM, NEFH
4glutathione derivative biosynthetic processGO:19016878.4GSTA3, GSTA1, GSTA2, GSTT1
5xenobiotic metabolic processGO:0068058.4GSTA2, GSTT1, GSTA3, GSTA1
6glutathione metabolic processGO:0067498.0GSTA2, GSTA1, GSTA3, GSTT1, GPX4
7small molecule metabolic processGO:0442817.7GSTA2, GSTT1, GSTA3, GSTA1, GPX4

Molecular functions related to Toxic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.6NEFM, NEFH
2glutathione peroxidase activityGO:0046028.8GSTT1, GPX4
3glutathione transferase activityGO:0043648.2GSTA1, GSTA3, GSTT1, GSTA2

Products for genes affiliated with Toxic Encephalopathy

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Sources for Toxic Encephalopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet