Toxic Encephalopathy malady

NINDS: Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness; loss of memory, vision, and/or intellect; headache; cognitive and behavioral problems; and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxicants.³¹

MalaCards: Toxic Encephalopathy, also known as neurotoxicity, is related to wernicke encephalopathy and aicardi-goutieres syndrome. An important gene associated with Toxic Encephalopathy is SYCN (syncollin), and among its related pathways are Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 and Glutathione metabolism. The compounds pge2 and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: Toxic encephalopathy, also known as toxic-metabolic encephalopathy, is a degenerative neurologic...⁴⁴ more...

Aliases & Descriptions:

toxic encephalopathy 6 30 8 neurotoxicity 6 31 neurotoxicity (disorder) 6

neurotoxicity syndromes 30 neurotoxicity syndrome 6 encephalopathies 43

Diseases related to toxic encephalopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 777)

id	Related Disease	Score	Top Affiliating Genes
1	wernicke encephalopathy	32.2	MAPT, GFAP, PRNP, SLC1A3
2	aicardi-goutieres syndrome	30.6	BCHE, CHAT, APP, MAPT, COX5A, TH
3	scrapie	30.5	APP, MAPT, CAST, NOS1, GFAP, PRNP
4	liver cirrhosis	29.3	FOS, MAOA, HSPA4, GLS, GLUL, CYP3A4
5	prion disease	28.1	BAX, IL1B, IL6, APP, MAPT, MAPK3
6	alcoholism	27.4	GSR, GRIN1, GRIN2A, GRIN2B, MAPT, MAOA
7	tauopathy	27.4	CDK5, APP, MAPT, MAPK8, HTT
8	febrile seizures	27.3	BDNF, IL1B, IL6, CALB1, GLUL, HMOX1
9	aids dementia complex	27.0	BDNF, IL1B, GOLPH3, TNF, TAT, SLC6A3
10	cerebral amyloid angiopathy	26.7	BCHE, IL6, APP, MAPT, ABCB1, ABCG2
11	muscular atrophy	26.6	PARP1, BCL2, CHAT, HTT, CASP3, CREB1
12	gliosis	26.6	CHAT, FOS, GRM5, IL6, APP, MAPT
13	limbic encephalitis	26.5	GSR, GRIA1, GRIN2B, IL6
14	hepatic encephalopathy	26.3	IL6, MAOA, MAOB, GLS, GLUL, TNF
15	acute lymphoblastic leukemia	26.1	BCL2, JUN, FOS, GSTM1, GSTT1, MAPK8
16	tremor	25.9	TPH1, CYP2C19, ABCB1, GFAP, SLC6A3, SLC6A4
17	intractable epilepsy	25.7	BDNF, CDK5, GSR, GRIN1, GRM5, MAPK3
18	renal cell carcinoma	25.4	PIK3CA, BAX, JUN, FOS, GSTT1, CASP9
19	hyperhomocysteinemia	25.3	BCHE, GSR, IL1B, IL6, APP, MAOB
20	hydrocephalus	25.3	BDNF, APP, MAPT, CASP3, NTF3, NOS1
21	convulsions	25.3	BDNF, CHRNA4, CDK5R1, FOS, GRM5, IL1B
22	parkinson's disease	25.2	PARP1, BDNF, BCHE, CHAT, CHRNA4, BAX
23	central nervous system disease	25.2	BDNF, CHAT, GRM5, APP, MAPT, HMOX1
24	motor neuron disease	25.1	BDNF, CHAT, CDK5, GSTM1, GSTT1, MAPT
25	homocysteine	24.9	BCHE, JUN, FOS, GSR, GSTM1, GSTT1
26	acute liver failure	24.5	IL1B, IL6, MAPK8, GLUL, HMOX1, TNF
27	twinning	24.3	BDNF, GSK3B, IL6, MAOA, CAT, GLS
28	thrombosis	24.2	PIK3CG, GSK3B, IL1B, IL6, CAT, CAST
29	jaundice	24.2	GSR, GSTM1, GSTT1, IL1B, IL6, APP
30	peripheral neuropathy	24.1	BDNF, GSTM1, GSTT1, IL6, CAT, TNF
31	sinusitis	23.9	PIK3CA, BAX, IL1B, IL6, MAPK1, TNF
32	huntington's disease	23.8	PARP1, BDNF, CHAT, GRIN1, GRIN2A, GRIN2B
33	sepsis	23.7	IL1B, IL6, MAPK8, GLUL, HMOX1, TNF
34	brain ischemia	23.3	PARP1, BDNF, FOS, GRIN2A, APP, MAPT
35	differentiating neuroblastoma	23.1	BDNF, BCL2, FOS, IL6, APP, MAPT
36	choroiditis	23.0	PIK3CG, BCL2, IL1B, APP, MAPK1, GPX1
37	influenza	22.9	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BAX, JUN
38	meningitis	22.9	PIK3CG, PARP1, GSR, IL1B, IL6, APP
39	encephalitis	22.6	PIK3CG, BDNF, BCL2, JUN, CDK5, FOS
40	blindness	22.1	PIK3CG, GSR, IL1B, IL6, MAPT, MAOA
41	cataract	21.8	PARP1, FOS, GSR, GSTA4, GSTM1, GSTT1
42	spinal cord injury	21.7	PARP1, BDNF, BCL2, JUN, FOS, GSR
43	amyotrophic lateral sclerosis	21.2	BDNF, BCL2, CHAT, BAX, JUN, CDK5
44	lateral sclerosis	21.2	BDNF, BCL2, CHAT, CHRNA4, BAX, JUN
45	seizures	21.1	PARP1, BDNF, CHAT, CHRNA4, JUN, CDK5R1
46	hepatitis	21.1	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PARP1, BDNF
47	myopathy	20.9	BDNF, BCL2, CHAT, BAX, FOS, IL1B
48	anemia	20.4	PARP1, BCHE, BCL2, GSR, GSTM1, GSTT1
49	pheochromocytoma	20.3	BCL2, CHAT, JUN, FOS, IL1B, IL6
50	neuropathy	20.3	PARP1, BDNF, BCHE, CHAT, JUN, GSR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to toxic encephalopathy:

²²

MGI Mouse Phenotypes related to toxic encephalopathy:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	GRM5, HTT, SYCN
2	respiratory system phenotype	MP:0005388	10.2	TH, NOS1, NTF3, TPH1, GLS, CDK5
3	liver/biliary system phenotype	MP:0005370	9.6	DECR1, TH, ABCB1, PLA2G1B, AKT1, GPX4
4	hematopoietic system phenotype	MP:0005397	9.2	GDNF, CSF3, SOD2, TOX, CYCS, CASP9
5	taste/olfaction phenotype	MP:0005394	8.9	SLC18A2, SLC6A3, CASP9, CASP3, HTT, MAPK1
6	no phenotypic analysis	MP:0003012	8.9	GPX5, HTT, PTGS2, CYP3A43, ABCG2, PRNP
7	other phenotype	MP:0005395	8.9	SOD2, PRNP, ABCG2, ABCB1, NOS1, PTGS2
8	immune system phenotype	MP:0005387	8.8	GFAP, TOX, DNTT, SYCN, PRNP, SOD2
9	hearing/vestibular/ear phenotype	MP:0005377	8.4	CALB1, CASP3, ABCB1, SOD2, SLC1A3, HTT
10	digestive/alimentary phenotype	MP:0005381	8.3	PDYN, GFAP, TOX, SLC18A2, GDNF, NOS1
11	normal phenotype	MP:0002873	8.2	GLS, AKT1, NTF3, CREB1, NOS1, GFAP
12	skeleton phenotype	MP:0005390	7.8	CASP3, AKT1, PTGS2, CYCS, NOS1, PDYN
13	adipose tissue phenotype	MP:0005375	7.7	PTGS2, PLA2G1B, NOS1, PDYN, SOD2, TNF
14	integument phenotype	MP:0010771	7.3	MAPT, HTT, TPH1, PNPLA6, NGF, PDYN
15	reproductive system phenotype	MP:0005389	6.9	AKT1, CA4, CASP3, HTT, TNF, PTGS2
16	tumorigenesis	MP:0002006	6.6	CAT, AKT1, TNF, PTGS2, CYP1B1, MAPK8
17	nervous system phenotype	MP:0003631	6.2	GDNF, GAP43, SLC18A2, SLC1A2, SLC6A4, SLC1A3
18	vision/eye phenotype	MP:0005391	6.1	PTGS2, CYP1B1, NTF3, NOS1, NGF, KRIT1
19	muscle phenotype	MP:0005369	6.1	NOS1, CREB1, NTF3, PTGS2, TNF, GFAP
20	mortality/aging	MP:0010768	5.1	GDNF, GAP43, SLC18A2, SLC1A2, SLC6A4, SLC6A3
21	cardiovascular system phenotype	MP:0005385	4.4	PNPLA6, NTF3, CYCS, PTGS2, TNF, TPH1
22	behavior/neurological phenotype	MP:0005386	4.4	GLUL, GSTM1, GSK3B, FOS, CDK5R1, CDK5
23	growth/size phenotype	MP:0005378	4.3	MAPK1, PIK3CA, PIK3CB, PIK3CG, PARP1, BDNF
24	cellular phenotype	MP:0005384	3.4	GAP43, TUBA1A, HMOX1, AKT1, CASP9, CAST
25	homeostasis/metabolism phenotype	MP:0005376	2.1	NEFM, SLC18A2, SLC6A4, SLC1A3, SLC6A3, SOD2

Articles related to toxic encephalopathy:

id	Title	Authors	Year	Affiliating Genes
1	Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy. (17938643)	Erdelyi D.J.... Szalai C.	2007	ABCG2, ABCB1
2	Interaction between smoking and glutathione S-transferase polymorphisms in solvent-induced chronic toxic encephalopathy. (14992466)	Ahmadi A.... Soderkvist P.	2002	HMOX1, GSTT1, GSTM1

Genes related to toxic encephalopathy according to GeneCards:

(show top 50)    (show all 110)

id	Symbol	Description	Score	GeneCards Section Context
1	SYCN	syncollin	11.0
2	GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	11.0
3	NDUFB11	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa	11.0
4	CYP2D7P1	cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1	11.0
5	GSTA3	glutathione S-transferase alpha 3	11.0
6	NDOR1	NADPH dependent diflavin oxidoreductase 1	11.0
7	NEFH	neurofilament, heavy polypeptide	11.0
8	CYP4X1	cytochrome P450, family 4, subfamily X, polypeptide 1	11.0	Disorders
9	TUBA1A	tubulin, alpha 1a	11.0
10	NEFM	neurofilament, medium polypeptide	11.0
11	GOLPH3	golgi phosphoprotein 3 (coat-protein)	11.0
12	CA4	carbonic anhydrase IV	11.0
13	SYN1	synapsin I	11.0
14	GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	11.0
15	PLA2G1B	phospholipase A2, group IB (pancreas)	11.0
16	GSTA4	glutathione S-transferase alpha 4	11.0
17	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	11.0
18	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	11.0
19	GPX4	glutathione peroxidase 4	11.0
20	PNPLA6	patatin-like phospholipase domain containing 6	11.0
21	C2orf61	chromosome 2 open reading frame 61	11.0	Disorders
22	GSTA2	glutathione S-transferase alpha 2	11.0
23	CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	11.0
24	DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	11.0
25	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	11.0
26	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11.0
27	GPX1	glutathione peroxidase 1	11.0
28	KRIT1	KRIT1, ankyrin repeat containing	11.0
29	DNTT	deoxynucleotidyltransferase, terminal	11.0
30	GAP43	growth associated protein 43	11.0
31	GLS	glutaminase	11.0
32	GLUL	glutamate-ammonia ligase	11.0
33	GSTA1	glutathione S-transferase alpha 1	11.0
34	NLRP1	NLR family, pyrin domain containing 1	11.0
35	TPH1	tryptophan hydroxylase 1	11.0
36	TAT	tyrosine aminotransferase	11.0
37	CALM1	calmodulin 1 (phosphorylase kinase, delta)	11.0
38	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0
39	CALB1	calbindin 1, 28kDa	11.0
40	SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	11.0
41	CALM3	calmodulin 3 (phosphorylase kinase, delta)	11.0
42	CAST	calpastatin	11.0
43	PDYN	prodynorphin	11.0
44	NTF3	neurotrophin 3	11.0
45	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	11.0
46	CHAT	choline O-acetyltransferase	11.0
47	CDK5	cyclin-dependent kinase 5	11.0
48	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0
49	TOX	thymocyte selection-associated high mobility group box	11.0
50	TH	tyrosine hydroxylase	11.0

Pathways related to toxic encephalopathy according to GeneDecks:

(show top 50)    (show all 387)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.9	PIK3CD
2	Glutathione metabolism41	10.7	GSTA1, GSR, GSTA2, GSTA3, GPX5, GPX4
3	Glutathione metabolism10	10.4	GSTA3, GPX5, GSR, GSTA1, GSTA2, GPX1
4	Signal transduction_PTEN pathway41	10.4	CASP9, GSK3B
5	Glutathione metabolism20	10.2	GPX5, GSTM1, GSTA4, GSTT1, GPX1, GPX4
6	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.2	CREB1, CYCS, AKT1, MAPK3, PIK3CD, PIK3CB
7	Adipocytokines & Insulin Signaling37	10.1	PIK3CG, FOS, PIK3CD, PIK3CB, GSK3B
8	Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling41	10.1	CDK5, PDYN, CREB1, CALM1, CALM3, GRIN2B
9	Colorectal cancer20	10.0	PIK3CB, PIK3CD, PIK3CG, FOS, GSK3B, MAPK8
10	Metabolism of xenobiotics by cytochrome P45020	9.9	CYP1B1, GSTT1, CYP3A43, CYP2B6, CYP2C19, CYP3A5
11	Glutamic acid signaling10	9.9	SLC1A2, SLC1A3, GRIN1, GLUL, GRIK1, GRIA1
12	Apoptosis and survival Role of CDK5 in neuronal death and survival10	9.9	NGF, CYCS, CASP9, CDK5R1, CDK5, BCL2
13	Drug metabolism - cytochrome P45020	9.8	GSTA2, GSTA3, GSTA4, GSTM1, GSTT1, MAOA
14	Development GDNF family signaling10	9.7	GDNF, PIK3CB, PIK3CD, PIK3CA, MAPK3, CREB1
15	Taxane Pathway, Pharmacokinetics34	9.6	ABCB1, CYP3A5, CYP3A4, CYP1B1, MAP2, MAPT
16	Development_GDNF family signaling41	9.3	PIK3CA, PIK3CB, GDNF, CREB1, MAPK1, MAPK3
17	Glutamatergic synapse20	9.3	GRIN2C, GRIA1, PLA2G1B, GLUL, GLS, MAPK1
18	Pathogenesis of ALS36	8.9	SLC1A2, SLC1A3, BAX, GRIA1, GRIN1, GRIN2A
19	Development_Neurotrophin family signaling41	8.8	NGF, NTF3, AKT1, MAPK1, MAPK3, MAPK8
20	Development Neurotrophin family signaling10	8.8	PIK3CA, PIK3CD, PIK3CB, BDNF, MAPK3, MAPK1
21	Huntingtons disease20	8.8	GRIN1, BDNF, BAX, GRIN2B, GRM5, GPX1
22	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	8.8	PDYN, NOS1, FOS, GRIA1, GRIN1, GRIN2A
23	Development_HGF signaling pathway41	8.8	MAPK8, PIK3CD, PIK3CB, MAPK3, PIK3CA, GSK3B
24	Development Thrombopoietin-regulated cell processes10	8.7	GSK3B, FOS, JUN, PIK3CA, MAPK3, MAPK1
25	Development_Thrombopoietin-regulated cell processes41	8.7	MAPK1, MAPK3, GSK3B, PIK3CB, PIK3CD, PIK3CA
26	Development HGF signaling pathway10	8.4	PIK3CB, PIK3CD, PIK3CA, MAPK1, JUN, FOS
27	Signal transduction PTEN pathway10	8.4	PIK3CB, PIK3CD, CASP9, CASP3, MAPK1, MAPK3
28	Neuroscience3	8.4	NOS1, CDK5, CDK5R1, CREB1, NGF, GFAP
29	Cholinergic synapse20	8.4	MAPK1, MAPK3, CREB1, CHAT, BCL2, AKT1
30	TRKA Signaling36	8.4	TRIO, CREB1, CASP9, JUN, CYCS, CASP3
31	Amyotrophic lateral sclerosis (ALS)20	8.2	CASP3, GPX1, GRIN2C, GRIN2B, GRIN2A, GRIA1
32	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.2	SOD2, BAX, JUN, NOS1, CYCS, MAPK3
33	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	8.2	JUN, BAX, SOD2, NOS1, CYCS, MAPK1
34	Toxoplasmosis20	7.9	MAPK3, TNF, AKT1, CYCS, PLA2G1B, MAPK8
35	Neurotrophin signaling pathway20	7.8	MAPK3, MAPK8, GSK3B, JUN, BAX, BCL2
36	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	7.8	PIK3CD, PIK3CB, PIK3CA, BCL2, BAX, NGF
37	Endothelin-1 Signaling Pathway36	7.7	NOS1, CASP3, MAPK3, IL6, IL1B, CSF3
38	Apoptosis20	7.7	TNF, BAX, PIK3CB, PIK3CD, PIK3CA, BCL2
39	Osteoclast differentiation20	7.5	MAPK1, MAPK3, TNF, CREB1, AKT1, MAPK8
40	Toll-like receptor signaling pathway20	7.2	IL6, IL1B, PIK3CB, MAPK8, MAPK3, MAPK1
41	Chagas disease (American trypanosomiasis)20	7.2	TNF, AKT1, MAPK1, PIK3CB, PIK3CD, PIK3CA
42	Pathways in cancer20	7.1	AKT1, CASP3, MAPK1, MAPK8, MAPK3, PIK3CB
43	Influenza A20	7.0	IL1B, CASP9, PIK3CB, PIK3CD, AKT1, TNF
44	Pertussis20	6.9	MAPK1, TNF, CASP3, CALM3, JUN, FOS
45	Alzheimers disease20	6.8	CDK5R1, CASP9, TNF, CYCS, NOS1, COX5A
46	14-3-3 Induced Apoptosis36	6.7	CASP3, FOS, IL1B, MAPK8, MAPK3, MAPK1
47	DHA Signaling36	6.7	MAPT, CASP3, CASP9, AKT1, CYCS, NTF3
48	Tuberculosis20	6.6	MAPK8, CYCS, TNF, BCL2, BAX, CREB1
49	PEDF Induced Signaling36	6.3	GRIN2B, GRIN2C, IL1B, IL6, MAPK3, MAPK1
50	MIF Regulation of Innate Immune Cells36	6.1	MAPK3, IL1B, JUN, PLA2G1B, MAPK1, PTGS2

Compounds related to toxic encephalopathy according to GeneDecks:

(show top 50)    (show all 671)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.1	GSR, GPX4, HMOX1, CREB1, PLA2G1B, NOS1
2	n acetylcysteine32	10.1	BDNF, CDK5, FOS, MAPT, GPX4
3	egcg32	9.6	PIK3CG, APP, MAPK8, MAPK3, CAT, CASP9
4	valproic acid32 34 9 18 9	13.5	BDNF, GSK3B, GSR, CYP1B1, CYP3A4, CYP3A43
5	nifedipine32 9 9	11.3	PIK3CG, BDNF, CHAT, GRIN2B, CALM1, HMOX1
6	methamphetamine32 9 9	11.2	BDNF, CHAT, MAP2, MAOA, MAOB, CALB1
7	epinephrine32 9 18 9	12.1	BDNF, GSR, APP, MAPK3, MAOB, CREB1
8	imipramine32 34 9 18 9	13.1	BDNF, CHAT, MAOA, MAOB, CYP3A4, CYP2A6
9	h2o232	8.9	PIK3CB, PIK3CG, BDNF, BCHE, CDK5, MAPT
10	selegiline32 9 9	10.8	BDNF, BCHE, MAOA, MAOB, CAT, CYP3A4
11	clozapine32 34 9 9	11.7	FOS, GRIN2B, CYP1B1, CYP3A4, CYP2A6, NOS1
12	alanine32	8.6	BCHE, CHAT, GSTA1, IL6, MAPK3, HTT
13	ketamine32 9 9	10.6	BDNF, GRIN2B, HSPA4, HMOX1, CYP3A4, CYP2B6
14	cysteine32	8.3	PARP1, CDK5R1, GSTM1, GRIN1, MAPT, MAOB
15	flavopiridol32 9 9	10.3	PIK3CG, PARP1, BCL2, BAX, CDK5, MAPK8
16	creatinine32	8.3	BDNF, BCHE, GSTM1, GSTT1, APP, MAPT
17	glutamine32	8.3	PIK3CG, CDK5, GRIA1, GRIN1, APP, MAPT
18	cocaine32 9 9	10.2	BDNF, BCHE, CHAT, CDK5, FOS, GSR
19	atp32	8.2	PIK3CB, PIK3CA, PARP1, BDNF, CHAT, CDK5
20	acetylcholine32 9 18 9	11.0	BDNF, BCHE, CHAT, CHRNA4, APP, MAPT
21	cyclosporin a32 42	8.9	PIK3CA, PIK3CG, JUN, APP, MAPT, CASP9
22	adenylate32	7.9	PIK3CA, PIK3CG, BDNF, FOS, GSR, APP
23	arginine32	7.9	PIK3CA, BCHE, CDK5, GSR, GSTT1, GRIA1
24	vinblastine32 9 9	9.7	BDNF, BCL2, BAX, JUN, MAPT, MAPK8
25	doxorubicin32 34 9 9	10.6	PIK3CA, PIK3CG, PARP1, BDNF, GSR, GSTT1
26	sb 20358032 42	8.5	PARP1, BCL2, FOS, IL6, HSPA4, CASP3
27	calcium32 9 18 9	10.4	PIK3CD, BDNF, BCHE, CHAT, CDK5, FOS
28	etoposide32 42 9 9	10.3	PIK3CB, PIK3CA, PIK3CG, PARP1, BCL2, BAX
29	dopamine32 9 18 9	10.2	PIK3CA, BDNF, CHAT, CHRNA4, CDK5, FOS
30	lactate32	7.2	PIK3CA, BDNF, BCHE, CHAT, GSR, GSTM1
31	celecoxib32 42 34 9 18 9	12.2	PIK3CG, PARP1, BCL2, BAX, IL1B, MAPK8
32	diphenyleneiodonium32	7.0	JUN, IL1B, MAPK8, MAPK3, MAPK1, CASP3
33	thapsigargin32 42	8.0	PIK3CG, BDNF, BCL2, APP, MAPK8, MAPK3
34	glutamate32	6.9	PIK3CB, PIK3CA, BCHE, CHAT, CDK5, CDK5R1
35	resveratrol32 9 18 9	9.6	PIK3CA, PIK3CG, PARP1, BCL2, BAX, JUN
36	cisplatin32 34 9 9	9.5	PIK3CA, PARP1, BDNF, BCHE, BCL2, BAX
37	ly29400232	6.4	PIK3CB, PIK3CA, PIK3CG, JUN, FOS, IL1B
38	phosphatidylinositol32	6.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BDNF, BCL2
39	testosterone32 9 18 9	9.2	PIK3CA, BDNF, CHAT, GSK3B, GSTA3, GSTM1
40	nmda32 42	7.2	PIK3CA, BDNF, BCHE, CHAT, CDK5, FOS
41	15-deoxy-delta-12,14-prostaglandin j232	6.1	PIK3CG, JUN, FOS, IL1B, IL6, MAPK8
42	triptolide32	6.1	PARP1, BCL2, BAX, JUN, IL1B, IL6
43	oxygen32 18	6.8	PARP1, BDNF, BCHE, BCL2, BAX, JUN
44	paclitaxel32 34 9 9	8.7	PIK3CA, PIK3CG, PARP1, BDNF, BCL2, BAX
45	tyrosine32	5.5	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BDNF, CHAT
46	pdtc32	5.2	PIK3CA, PIK3CG, PARP1, BCL2, JUN, FOS
47	serine32	4.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BDNF, BCHE
48	actinomycin d32	3.7	PIK3CA, PIK3CG, PARP1, BDNF, BCL2, BAX
49	cycloheximide32	3.5	PIK3CG, PARP1, BDNF, BCL2, CHAT, BAX
50	dexamethasone32 42 34 9 9	7.3	PIK3CA, PARP1, BCL2, CHAT, JUN, FOS

Cellular components related to toxic encephalopathy according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	N-methyl-D-aspartate selective glutamate receptor complex	GO:017146	10.3	GRIN1, GRIN2A, GRIN2B, GRIN2C
2	outer membrane-bounded periplasmic space	GO:030288	10.3	GRIN2C, GRIN2B, GRIN2A, GRIN1
3	dendrite	GO:030425	10.2	HTT, GRIN1, GRIA1, CDK5R1, CDK5, CHRNA4
4	postsynaptic density	GO:014069	10.1	GRIN2C, GRIN2B, GRIN2A, GRIN1, GRIA1, CDK5R1
5	neuronal cell body	GO:043025	10.1	CALB1, SLC6A3, SLC1A3, SLC18A2, MAP2, GRIA1
6	dendritic spine	GO:043197	9.9	SLC1A3, NOS1, APP, GRIN1, GRIA1, GSK3B
7	postsynaptic membrane	GO:045211	9.9	GRIN2C, GRIN2B, GRIN2A, GRIN1, GRIK1, GRIA1
8	axon	GO:030424	9.8	SLC6A3, NEFH, NEFM, GAP43, CALB1, HTT
9	cell junction	GO:030054	9.7	GAP43, SYN1, GRIN2C, GRIN2B, GRIN2A, GRIN1
10	cell surface	GO:009986	9.0	SLC1A3, ABCB1, CYP3A4, TNF, CA4, APP
11	endoplasmic reticulum membrane	GO:005789	8.7	PNPLA6, CYP2J2, CYP3A5, CYP4X1, CYP2C19, CYP2B6
12	mitochondrion	GO:005739	7.8	GLS, GLUL, CREB1, TAT, DECR1, SOD2
13	plasma membrane	GO:005886	6.9	KRIT1, PDYN, NTF3, TNF, AKT1, CA4
14	cytosol	GO:005829	4.1	SLC6A4, GLUL, GLS, CASP9, CAT, CASP3

Biological processes related to toxic encephalopathy according to GeneDecks:

(show top 50)    (show all 72)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione metabolic process	GO:006749	10.6	GSTT1, GSTA2, GSTA4, GSTA3, GSR, GSTA1
2	regulation of excitatory postsynaptic membrane potential	GO:060079	10.4	GRIN1, GRIN2C, CDK5, GRIN2A, GRIN2B
3	neurotransmitter biosynthetic process	GO:042136	10.4	SLC6A3, MAOA, NOS1, TH
4	exogenous drug catabolic process	GO:042738	10.3	NOS1, CYP2C19, CYP3A4, CYP2A6, CYP2B6
5	glutamate receptor signaling pathway	GO:007215	10.3	GRIN2B, GRIK1, GRIN2A, GRIN2C
6	response to oxidative stress	GO:006979	10.2	CHRNA4, GPX4, GPX5, HMOX1, PTGS2, PRNP
7	locomotory behavior	GO:007626	10.2	CALB1, SLC18A2, SLC6A3, TH, CHRNA4, APP
8	sensory perception of pain	GO:019233	10.2	NGF, MAPK3, GRIN2A, CDK5, CHRNA4, GRIN1
9	axon cargo transport	GO:008088	10.1	MAPT, NEFM, HTT, APP
10	visual learning	GO:008542	10.0	APP, HTT, CDK5, GRIN1, GRIN2A
11	phosphatidylinositol-mediated signaling	GO:048015	10.0	CASP9, PIK3CB, GSK3B, PIK3CA, NGF, AKT1
12	response to wounding	GO:009611	10.0	SLC1A3, GFAP, CASP3, GAP43, GRIN2C, GRIN2A
13	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:008635	10.0	BAX, CASP3, CASP9, CYCS
14	peptidyl-threonine phosphorylation	GO:018107	9.9	MAP2, MAPK8, CDK5R1, BCL2, CDK5
15	response to nicotine	GO:035094	9.8	SLC6A3, NGF, CHRNA4, BCL2, HMOX1
16	hippocampus development	GO:021766	9.7	CDK5, GRIN2B, GRIN2A, GSK3B, CDK5R1
17	neuron projection development	GO:031175	9.7	GDNF, NGF, MAP2, APP, IL6, CDK5R1
18	xenobiotic metabolic process	GO:006805	9.7	MAOA, GSTM1, GSTA4, GSTA3, GSTA2, GSTA1
19	response to toxin	GO:009636	9.6	MAOB, BAX, GPX1, CYP1B1, BCL2, SLC6A4
20	activation of pro-apoptotic gene products	GO:008633	9.6	BCL2, AKT1, CDK5, MAPK8, BAX
21	response to ethanol	GO:045471	9.6	TH, MAOB, GRIN2A, GRIN2B, GRIN1, CHAT
22	fibroblast growth factor receptor signaling pathway	GO:008543	9.5	CREB1, CALM3, CASP9, MAPK1, MAPK3, GSK3B
23	epidermal growth factor receptor signaling pathway	GO:007173	9.5	PIK3CA, MAPK1, AKT1, CREB1, MAPK3, GSK3B
24	axon guidance	GO:007411	9.4	MAPK1, TRIO, NTF3, CREB1, PRNP, GDNF
25	positive regulation of neuron apoptotic process	GO:043525	9.4	CDK5, JUN, CASP3, CASP9, TNF, CDK5R1
26	peptidyl-serine phosphorylation	GO:018105	9.3	GSK3B, CDK5R1, CDK5, BCL2, AKT1, MAPK8
27	B cell homeostasis	GO:001782	9.3	CASP3, BCL2, PIK3CD, BAX
28	memory	GO:007613	9.2	NGF, SLC6A4, PTGS2, IL1B, GRIN2A, CHAT
29	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.2	MAPK3, MAPK8, FOS, MAPK1, JUN, HMOX1
30	induction of apoptosis by intracellular signals	GO:008629	9.1	BAX, CASP3, CASP9, CYCS, MAPK8, BCL2
31	neuron apoptotic process	GO:051402	9.1	BCL2, NLRP1, CASP3, HTT, CDK5, BAX
32	stress-activated MAPK cascade	GO:051403	9.1	CREB1, MAPK3, MAPK8, MAPK1, JUN, FOS
33	synaptic transmission	GO:007268	9.1	GLUL, CREB1, PDYN, SYN1, SLC6A3, SLC1A3
34	release of cytochrome c from mitochondria	GO:001836	9.0	JUN, SOD2, BAX, BCL2, GPX1, CASP3
35	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.0	AKT1, TNF, IL6, GSK3B, BCL2, PIK3CA
36	negative regulation of neuron apoptotic process	GO:043524	8.9	JUN, GDNF, BDNF, NGF, NTF3, SOD2
37	MyD88-independent toll-like receptor signaling pathway	GO:002756	8.9	MAPK1, JUN, CREB1, MAPK8, MAPK3, FOS
38	TRIF-dependent toll-like receptor signaling pathway	GO:035666	8.8	MAPK8, CREB1, MAPK3, MAPK1, FOS, JUN
39	toll-like receptor 2 signaling pathway	GO:034134	8.8	JUN, FOS, MAPK8, MAPK3, CREB1, MAPK1
40	platelet activation	GO:030168	8.7	CALM3, AKT1, IL6, PIK3CB, MAPK1, APP
41	cellular response to organic substance	GO:071310	8.7	CASP3, CALB1, MAP2, IL1B, BAX, BCL2
42	nerve growth factor receptor signaling pathway	GO:048011	8.6	MAPK3, GSK3B, PIK3CB, PIK3CA, TRIO, CALM3
43	response to glucocorticoid stimulus	GO:051384	8.6	TAT, PTGS2, TNF, IL6, IL1B, BCHE
44	response to hypoxia	GO:001666	8.5	SLC6A4, TH, IL1B, CHRNA4, CAT, BCL2
45	toll-like receptor 1 signaling pathway	GO:034130	8.5	JUN, FOS, MAPK8, MAPK3, MAPK1, CREB1
46	small molecule metabolic process	GO:044281	8.2	GSTA3, PTGS2, CYP1B1, CYP3A4, CYP3A43, CYP2A6
47	anti-apoptosis	GO:006916	8.0	HMOX1, AKT1, HTT, GPX1, IL1B, NGF
48	negative regulation of apoptotic process	GO:043066	7.8	MAPK8, PIK3CG, AKT1, TNF, CAT, GSK3B
49	innate immune response	GO:045087	7.8	NLRP1, PIK3CD, CREB1, MAPK1, MAPK3, MAPK8
50	response to drug	GO:042493	7.7	ABCG2, CREB1, PTGS2, TNF, CA4, MAOB

Molecular functions related to toxic encephalopathy according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	aromatase activity	GO:070330	10.5	CYP1B1, CYP3A43, CYP4X1, CYP3A5, CYP2J2
2	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:046934	10.4	PIK3CG, PIK3CA, PIK3CD, PIK3CB
3	phosphatidylinositol 3-kinase activity	GO:035004	10.4	PIK3CG, PIK3CA, PIK3CD, PIK3CB
4	glutathione peroxidase activity	GO:004602	10.4	GPX1, GPX5, GPX4, GSTT1
5	glutathione transferase activity	GO:004364	10.4	GSTT1, GSTM1, GSTA4, GSTA3, GSTA2, GSTA1
6	1-phosphatidylinositol-3-kinase activity	GO:016303	10.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG
7	N-methyl-D-aspartate selective glutamate receptor activity	GO:004972	10.3	GRIN2C, GRIN2B, GRIN2A, GRIN1
8	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavopr	GO:016712	10.2	CYP2B6, CYP2A6, CYP3A4, CYP1B1
9	extracellular-glutamate-gated ion channel activity	GO:005234	10.2	GRIN2C, GRIN2B, GRIN2A, GRIN1, GRIK1, GRIA1
10	monooxygenase activity	GO:004497	10.2	CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
11	monoamine transmembrane transporter activity	GO:008504	10.2	SLC6A3, SLC6A4, SLC18A2
12	kinase activity	GO:016301	10.0	AKT1, GSK3B, CDK5R1, CDK5, PIK3CA
13	electron carrier activity	GO:009055	10.0	COX5A, CYP2J2, CYP3A5, CYP4X1, CYP2C19, CYP2B6
14	neurotransmitter binding	GO:042165	10.0	GRIN2B, GRIN2A, GRIN1
15	glutamate binding	GO:016595	9.9	SLC1A3, GRIN2A, GRIN1
16	iron ion binding	GO:005506	9.8	CYP4X1, CYP3A5, CYP2J2, NOS1, NDOR1, TH
17	heme binding	GO:020037	9.3	CAT, NOS1, CYP2J2, CYP3A5, CYP4X1, CYCS
18	enzyme binding	GO:019899	8.9	CYP2A6, CYP2C19, NLRP1, CSF3, SLC18A2, CYP3A4
19	protein homodimerization activity	GO:042803	8.2	SLC6A4, ABCG2, PTGS2, HMOX1, CAT, MAOB
20	protein binding	GO:005515	4.3	CREB1, CYCS, TNF, TRIO, AKT1, CA4