TEN
MCID: TXC012
MIFTS: 49

Toxic Epidermal Necrolysis (TEN) malady

Skin category

Summaries for Toxic Epidermal Necrolysis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Toxic epidermal necrolysis (TEN), also known as Lyell\'s syndrome, is a rare, life-threatening skin... more...

MalaCards: Toxic Epidermal Necrolysis, also known as staphylococcal scalded skin syndrome, is related to stevens-johnson syndrome and erythema multiforme. An important gene associated with Toxic Epidermal Necrolysis is HLA-B (major histocompatibility complex, class I, B), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and chromium have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and small intestine, and related mouse phenotype hematopoietic system.

Description from OMIM:47 608579

Aliases & Classifications for Toxic Epidermal Necrolysis

Sources:
43NIH Rare Diseases, 47OMIM, 45Novoseek, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

toxic epidermal necrolysis 43 47 45 61
staphylococcal scalded skin syndrome 43 61
mucocutaneous exfoliative disease 43
sick sinus syndrome 61
ssss 43
ten 43


External Ids:

ICD1025 L51.2

Related Diseases for Toxic Epidermal Necrolysis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Toxic Epidermal Necrolysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 671)
idRelated DiseaseScoreTop Affiliating Genes
1stevens-johnson syndrome32.1HSPG2, GZMB, GNLY, FAS, FASLG, PSORS1C1
2erythema multiforme31.5HSPG2
3systemic lupus erythematosus30.8FASLG, FAS, HSPG2, KLRC2, KLRD1
4graft versus host disease30.7GZMB, FAS, FASLG
5polymyositis30.4HSPG2, GZMB, HLA-B
6lichen planus30.3GZMB
7arthritis30.3GZMB, HLA-B
8pemphigus vulgaris30.3CCL17
9aplastic anemia30.3FASLG, FAS, GZMB
10adenoma30.2HLA-B, HSPG2
11hepatitis c30.1FAS, HSPG2
12cystic fibrosis29.8HSPG2, CCL22, CCL17
13celiac disease29.5GZMB
14vitiligo29.5HLA-B
15anaplastic large cell lymphoma29.5GZMB, CCL17
16amyloidosis29.5HLA-B
17measles29.5GNLY
18thyroiditis29.5FASLG
19b-cell lymphomas29.5HLA-B, FAS, GZMB, CCL17
20ulcerative colitis29.5CCL22, CCL17, GZMB, HLA-B
21n syndrome11.4
22lyell syndrome10.8
23acute generalized exanthematous pustulosis10.8
24syncope10.7
25bullous impetigo10.7
26cutaneous lupus erythematosus10.7
27atrioventricular block10.6
28ritter's disease10.6
29brugada syndrome10.5
30burns10.5
31pemphigus10.5
32sick sinus syndrome 110.5
33sick sinus syndrome 310.4
34sick sinus syndrome 210.4
35parotitis10.4
36ecthyma10.4
37tuberculosis10.4
38micro syndrome10.4
39char syndrome10.4
40cytomegalovirus infection10.4
41hypersensitivity syndrome, carbamazepine-induced10.4
42sepsis10.4
43leukopenia10.4
44subacute cutaneous lupus erythematosus10.4
45paraneoplastic pemphigus10.4
46thyrotoxicosis10.4
47single ventricular heart10.4
48sick sinus syndrome 2, autosomal dominant10.4
49sick sinus syndrome 1, autosomal recessive10.4
50congenital ichthyosiform erythroderma10.3

Graphical network of the top 20 diseases related to Toxic Epidermal Necrolysis:



Diseases related to toxic epidermal necrolysis

Clinical Features for Toxic Epidermal Necrolysis

Sources:
47OMIM
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Clinical features from OMIM:

608579

Drugs & Therapeutics for Toxic Epidermal Necrolysis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Toxic Epidermal Necrolysis

Drug clinical trials:

Search ClinicalTrials for Toxic Epidermal Necrolysis

Search NIH Clinical Center for Toxic Epidermal Necrolysis

Search CenterWatch for Toxic Epidermal Necrolysis

Genetic Tests for Toxic Epidermal Necrolysis

Anatomical Context for Toxic Epidermal Necrolysis

Sources:
33MalaCards
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MalaCards organs/tissues related to Toxic Epidermal Necrolysis:

33
Whole blood, Brain, Small intestine, Colon, Liver, Lung, Skin, Monocytes, T cells, B cells

Animal Models for Toxic Epidermal Necrolysis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Toxic Epidermal Necrolysis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.7F2RL2, CD68, POU5F1, HLA-B, FASLG, FAS

Publications for Toxic Epidermal Necrolysis

Sources:
51PubMed
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Articles related to Toxic Epidermal Necrolysis:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China. (24399721)
2013
2
Characteristics of toxic epidermal necrolysis and Stevens-Johnson syndrome: a 5-year retrospective study. (23691693)
2013
3
Fatal Case of Toxic Epidermal Necrolysis Caused by Cefozopran and Associated with Psoriasis. (24048229)
2013
4
Stevens-Johnson syndrome/toxic epidermal necrolysis: are drug dictionaries correctly informing physicians regarding the risk? (23743691)
2013
5
Levetiracetam: a possible new inducer of toxic epidermal necrolysis and Stevens-Johnson syndrome in 2 cases. (23324778)
2013
6
Stevens-Johnson syndrome / toxic epidermal necrolysis: an Asia-Pacific perspective. (24260726)
2013
7
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
8
Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with lupus erythematosus: a descriptive study of 17 cases from a national registry and review of the literature. (22014091)
2012
9
Toxic Epidermal Necrolysis induced by rarely implicated drugs. (22529493)
2012
10
Toxic epidermal necrolysis in an irradiated patient treated with a nanocrystalline silver dressing. (22548040)
2012
11
Roxithromycin-induced toxic epidermal necrolysis. (22777150)
2012
12
A systematic review of treatment of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children. (21467603)
2011
13
Acute generalized exanthematous pustulosis simulating toxic epidermal necrolysis: a case report and review of the literature. (21690532)
2011
14
Toxic epidermal necrolysis after percutaneous coronary intervention: which drug is the culprit? (21362353)
2011
15
Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients. (21424386)
2011
16
Use of the nasal bridle to secure fixation of an endotracheal tube in a child with facial blistering secondary to toxic epidermal necrolysis. (19501983)
2010
17
Toxic epidermal necrolysis-like cutaneous lupus erythematosus: A series of three patients. (20169302)
2010
18
Stevens-Johnson syndrome and toxic epidermal necrolysis: what do we know? (20844465)
2010
19
Toxic epidermal necrolysis (Lyell's disease). (19766401)
2010
20
Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations. (19874350)
2010
21
Beneficial therapeutic effect of plasmapheresis after unsuccessful treatment with corticosteroids in two patients with severe toxic epidermal necrolysis. (20609191)
2010
22
Systemic and local management at the onset of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. (20103059)
2010
23
Bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiology, risk factors, and predictive value of skin cultures. (20075702)
2010
24
Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis: immunohistochemical and serum cytokine analyses. (19874369)
2010
25
Stevens-Johnson Syndrome and toxic epidermal necrolysis overlap due to oral temozolomide and cranial radiotherapy. (19489660)
2009
26
Relevance and consequences of erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis in gynecology. (19277691)
2009
27
Combination therapy of intravenous immunoglobulin and corticosteroid in the treatment of toxic epidermal necrolysis and Stevens-Johnson syndrome: a retrospective comparative study in China. (19775409)
2009
28
Allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. (18638633)
2008
29
Energy requirements of pediatric patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. (18849560)
2008
30
Management of scalp toxic epidermal necrolysis and cranial osteomyelitis with serratus anterior myocutaneous pedicle flap: a case report. (17438486)
2007
31
Toxic epidermal necrolysis due to procaine penicillin. (17334486)
2007
32
Toxic epidermal necrolysis. (17224365)
2007
33
Glutathione-S-transferase pi expression in toxic epidermal necrolysis: a marker of putative oxidative stress in keratinocytes. (17139195)
2007
34
Toxic epidermal necrolysis and hemolytic uremic syndrome after allogeneic stem-cell transplantation. (17663696)
2007
35
Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus. (17728369)
2007
36
Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. (17251797)
2007
37
Toxic epidermal necrolysis and Steven-Johnson syndrome in oncologic patients. (17876963)
2007
38
Toxic epidermal necrolysis in oncologic patients. (17173477)
2006
39
Achieving asepsis of banana leaves for the management of toxic epidermal necrolysis. (16766833)
2006
40
The CD40/CD40 ligand system is expressed in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum. (16433803)
2006
41
Possible involvement of gelatinase A (MMP2) and gelatinase B (MMP9) in toxic epidermal necrolysis or Stevens-Johnson syndrome. (15449075)
2004
42
Acute generalized exanthematous pustulosis resembling toxic epidermal necrolysis caused by famotidine. (12636039)
2003
43
Immunoregulatory effector cells in drug-induced toxic epidermal necrolysis. (11048976)
2000
44
Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole. (10971734)
2000
45
Toxic epidermal necrolysis following morbilli-parotitis-rubella vaccination. (10565633)
1999
46
Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis. (9843104)
1998
47
Unusual bullous disorder with features of toxic epidermal necrolysis, bullous pemphigoid and cicatricial pemphigoid. (7671403)
1995
48
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. (4252396)
1969
49
Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. (4222069)
1966
50
Fatal reaction to sulfadimethoxine (Madribon). A case showing toxic epidermal necrolysis and leukopenia. (13957488)
1962

Genetic Variations for Toxic Epidermal Necrolysis

Expression for genes affiliated with Toxic Epidermal Necrolysis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Toxic Epidermal Necrolysis

Search GEO for disease gene expression data for Toxic Epidermal Necrolysis.

Pathways for genes affiliated with Toxic Epidermal Necrolysis

Sources:
54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Toxic Epidermal Necrolysis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1(glc)44510.5FAS, FASLG
2chromium4510.5FASLG, GNLY, GZMB
3concanamycin a45 6011.5GZMB, GNLY, FAS, FASLG
4dexamethasone45 50 29 1113.5CCL17, GZMB, FAS, FASLG
5ivig4510.4GZMB, FAS, FASLG
6phosphatidylserine45 29 1112.4FASLG, FAS, GZMB, HSPG2
7tacrolimus45 50 1112.4CCL22, CCL17, GZMB, FASLG, HLA-B
8atpo45 2911.4FASLG, FAS
9c2ceramide4510.4HSPG2, FAS, FASLG
10rantes4510.4GZMB, FAS, FASLG, HLA-B, F2RL2
11rottlerin4510.4HSPG2, FAS, FASLG
12paraffin4510.3GZMB, FAS, FASLG, HLA-B, CD68
13cyclosporin a45 29 6012.3CCL22, CCL17, GZMB, FAS, FASLG, HLA-B
14pge24510.3HSPG2, CCL22, FASLG, HLA-B, F2RL2
15oligonucleotide4510.2CCL22, GZMB, GNLY, FAS, FASLG, HLA-B
16lactate4510.2F2RL2, HLA-B, FASLG, FAS, GZMB
17vegf4510.2HSPG2, GZMB, FAS, FASLG, POU5F1, F2RL2
18ly2940024510.2FASLG, FAS, GZMB, HSPG2
19allopurinol45 50 1112.1TCF19, POU5F1, HLA-B, PPIAP9, PSORS1C3, PSORS1C1
20retinoic acid45 2411.0HSPG2, GZMB, FAS, FASLG, HLA-B, POU5F1
21fibrinogen4510.0CCL22, CCL17, HLA-B, F2RL2
22cytarabine45 50 1111.9FASLG, FAS, GZMB

GO Terms for genes affiliated with Toxic Epidermal Necrolysis

Sources:
16Gene Ontology
See all sources

Biological processes related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2immune responseGO:00695510.1HLA-B, FASLG, CCL17, CCL22
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS

Molecular functions related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.2FAS, KLRC2, KLRD1

Products for genes affiliated with Toxic Epidermal Necrolysis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Epidermal Necrolysis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet