TEN
MCID: TXC012
MIFTS: 38

Toxic Epidermal Necrolysis (TEN) malady

Skin diseases category

Summaries for Toxic Epidermal Necrolysis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Toxic epidermal necrolysis (TEN), also known as Lyell\'s syndrome, is a rare, life-threatening skin... more...

MalaCards: Toxic Epidermal Necrolysis, also known as staphylococcal scalded skin syndrome, is related to stevens-johnson syndrome and erythema multiforme. An important gene associated with Toxic Epidermal Necrolysis is HLA-B (major histocompatibility complex, class I, B), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and chromium have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype hematopoietic system.

Description from OMIM:46 608579

Aliases & Classifications for Toxic Epidermal Necrolysis

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42NIH Rare Diseases, 60UMLS, 46OMIM, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

toxic epidermal necrolysis 42 46 44 60
staphylococcal scalded skin syndrome 42 60
mucocutaneous exfoliative disease 42
sick sinus syndrome 60
ssss 42
ten 42


External Ids:

ICD1025 L51.2

Related Diseases for Toxic Epidermal Necrolysis

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17GeneCards, 18GeneDecks
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Diseases related to Toxic Epidermal Necrolysis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 677)
idRelated DiseaseScoreTop Affiliating Genes
1stevens-johnson syndrome32.0HLA-B, PSORS1C1, FASLG, FAS, HSPG2, GZMB
2erythema multiforme31.4HSPG2
3amyloidosis30.8HLA-B
4dermatitis30.7CCL22, CCL17, GZMB
5systemic lupus erythematosus30.7HSPG2, FAS, KLRC2, KLRD1, FASLG
6graft versus host disease30.7GZMB, FASLG, FAS
7contact dermatitis30.7CCL17
8lung cancer30.6HSPG2, GZMB, FAS, HLA-B, CCL22
9myeloma30.5FAS, FASLG, HLA-B
10lichen planus30.3GZMB
11arthritis30.3HLA-B, GZMB
12aplastic anemia30.3FASLG, FAS, GZMB
13hepatitis30.3FAS, GZMB, FASLG
14hepatocellular carcinoma30.3GZMB, FAS, F2RL2, FASLG
15rheumatoid arthritis30.3CD68, FASLG, FAS, GZMB, HSPG2, KLRD1
16melanoma30.3HSPG2, KLRD1, CD68, GZMB, HLA-B, FAS
17psoriasis30.3POU5F1, HLA-B, GZMB, CCL17, CCHCR1, CCL22
18thyroiditis30.0FASLG
19leukemia30.0HLA-B, GZMB, FAS, FASLG
20hepatitis c30.0HSPG2, FAS
21purpura29.9HSPG2
22hepatitis b29.9HLA-B, GZMB
23multiple sclerosis29.9HLA-B, FASLG, HSPG2
24influenza29.9GZMB, HLA-B
25hodgkin's lymphoma29.9CD68, HLA-B, CCL22, GZMB, CCL17
26adenoma29.9HLA-B, HSPG2
27myasthenia gravis29.7HLA-B
28cutaneous t cell lymphoma29.7GZMB, CCL17, FAS
29cystic fibrosis29.7CCL17, CCL22, HSPG2
30celiac disease29.5GZMB
31vitiligo29.5HLA-B
32anaplastic large cell lymphoma29.5CCL17, GZMB
33measles29.5GNLY
34ovarian cancer29.5F2RL2, FASLG, FAS
35ulcerative colitis29.5CCL22, CCL17, GZMB, HLA-B
36sick sinus syndrome11.5
37burns10.8
38lupus erythematosus10.8
39cutaneous lupus erythematosus10.7
40atrioventricular block10.6
41ritter's disease10.6
42exfoliation syndrome10.5
43brugada syndrome10.5
44skin disease10.5
45pemphigus10.5
46sick sinus syndrome 110.5
47sick sinus syndrome 310.4
48sick sinus syndrome 210.4
49parotitis10.4
50ecthyma10.4

Graphical network of the top 20 diseases related to Toxic Epidermal Necrolysis:



Diseases related to toxic epidermal necrolysis

Clinical Features for Toxic Epidermal Necrolysis

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46OMIM
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Clinical features from OMIM:

608579

Drugs & Therapeutics for Toxic Epidermal Necrolysis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Toxic Epidermal Necrolysis

Genetic Tests for Toxic Epidermal Necrolysis

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Anatomical Context for Toxic Epidermal Necrolysis

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32MalaCards
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MalaCards organs/tissues related to Toxic Epidermal Necrolysis:

32
Skin

Animal Models for Toxic Epidermal Necrolysis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Toxic Epidermal Necrolysis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.7F2RL2, CD68, POU5F1, HLA-B, FASLG, FAS

Publications for Toxic Epidermal Necrolysis

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Genetic Variations for Toxic Epidermal Necrolysis

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Expression for genes affiliated with Toxic Epidermal Necrolysis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Epidermal Necrolysis

Search GEO for disease gene expression data for Toxic Epidermal Necrolysis.

Pathways for genes affiliated with Toxic Epidermal Necrolysis

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Sources:
53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Toxic Epidermal Necrolysis

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44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1(glc)44410.5FAS, FASLG
2chromium4410.5FASLG, GNLY, GZMB
3concanamycin a44 5911.5GZMB, GNLY, FAS, FASLG
4dexamethasone44 49 28 1113.5CCL17, GZMB, FAS, FASLG
5ivig4410.4GZMB, FAS, FASLG
6phosphatidylserine44 28 1112.4FASLG, FAS, GZMB, HSPG2
7tacrolimus44 49 1112.4CCL22, CCL17, GZMB, FASLG, HLA-B
8atpo44 2811.4FASLG, FAS
9c2ceramide4410.4HSPG2, FAS, FASLG
10rantes4410.4GZMB, FAS, FASLG, HLA-B, F2RL2
11rottlerin4410.4HSPG2, FAS, FASLG
12paraffin4410.3GZMB, FAS, FASLG, HLA-B, CD68
13cyclosporin a44 28 5912.3CCL22, CCL17, GZMB, FAS, FASLG, HLA-B
14pge24410.3HSPG2, CCL22, FASLG, HLA-B, F2RL2
15oligonucleotide4410.2CCL22, GZMB, GNLY, FAS, FASLG, HLA-B
16lactate4410.2F2RL2, HLA-B, FASLG, FAS, GZMB
17vegf4410.2HSPG2, GZMB, FAS, FASLG, POU5F1, F2RL2
18ly2940024410.2FASLG, FAS, GZMB, HSPG2
19allopurinol44 49 1112.1TCF19, POU5F1, HLA-B, PPIAP9, PSORS1C3, PSORS1C1
20retinoic acid44 2411.0HSPG2, GZMB, FAS, FASLG, HLA-B, POU5F1
21fibrinogen4410.0CCL22, CCL17, HLA-B, F2RL2
22cytarabine44 49 1111.9FASLG, FAS, GZMB

GO Terms for genes affiliated with Toxic Epidermal Necrolysis

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16Gene Ontology
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Biological processes related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2immune responseGO:00695510.1HLA-B, FASLG, CCL17, CCL22
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.0FASLG, FAS

Molecular functions related to Toxic Epidermal Necrolysis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.2FAS, KLRC2, KLRD1

Products for genes affiliated with Toxic Epidermal Necrolysis

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  • Antibodies
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Sources for Toxic Epidermal Necrolysis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet