MCID: TXC001
MIFTS: 29

Toxic Megacolon malady

Gastrointestinal diseases category

Summaries for Toxic Megacolon

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66Wikipedia, 34MalaCards
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Wikipedia:66 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards: Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and ulcerative colitis. An important gene associated with Toxic Megacolon is TMC1 (transmembrane channel-like 1). Affiliated tissues include colon, spinal cord and bone, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Toxic Megacolon

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9Disease Ontology, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

toxic megacolon 9 11
megacolon, toxic 63


External Ids:

Disease Ontology9 DOID:1770
SNOMED-CT59 28536002
MeSH36 D008532

Related Diseases for Toxic Megacolon

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1megacolon11.3
2ulcerative colitis10.9
3crohn's disease10.6
4inflammatory bowel disease10.4
5cytomegalovirus infection10.4
6diarrhea10.3
7amyloidosis10.2
8compartment syndrome10.2
9disseminated intravascular coagulation10.2
10gastroenteritis10.2
11collagenous colitis10.2
12burns10.1
13amebiasis10.1
14kaposi's sarcoma10.1
15invasive aspergillosis10.1
16shigellosis10.1
17typhoid fever10.1
18aspergillosis10.1
19chorioretinitis10.1
20diverticulitis10.1
21dysentery10.1
22endophthalmitis10.1
23hepatitis10.1
24intestinal perforation10.1
25ischemia10.1
26leukemia10.1
27sarcoma10.1
28al amyloidosis10.1
29retroperitoneal fibrosis10.1
30spinal cord injury10.1
31sepsis10.1
32venous thrombosis10.1
33hiv/aids10.1

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Symptoms for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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34MalaCards
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MalaCards organs/tissues related to Toxic Megacolon:

34
Colon, Spinal cord, Bone, Bone marrow, Heart, Smooth muscle, Myeloid

Animal Models for Toxic Megacolon or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Toxic Megacolon:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.1FLOT2, TMC1

Publications for Toxic Megacolon

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53PubMed
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Articles related to Toxic Megacolon:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
2
Toxic megacolon. (22009735)
2012
3
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. (22726419)
2012
4
Toxic megacolon due to fulminant Clostridium Difficile colitis. (21861326)
2011
5
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. (22242068)
2010
6
Ulcerative colitis presenting as toxic megacolon. (21189707)
2010
7
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. (19899041)
2010
8
Management of acute colitis and toxic megacolon. (22131898)
2010
9
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
10
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
11
Invasive aspergillosis localised to the colon presenting as toxic megacolon. (17328784)
2007
12
A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates. (17671768)
2007
13
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
14
Early surgery for the treatment of toxic megacolon. (16172551)
2005
15
Inflammatory pseudopolyposis in a patient with toxic megacolon due to pseudomembranous colitis. (11757676)
2001
16
Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon. (11144376)
2000
17
Sub-total colectomy for perforated toxic megacolon in pregnancy. (15512196)
1998
18
Antibiotic-associated fulminant pseudomembranous colitis without toxic megacolon. (1449149)
1992
19
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
20
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
21
Toxic megacolon and perforation caused by Salmonella. (2765830)
1989
22
Toxic megacolon presenting in the leukocyte scan as distended transverse bowel. (3130613)
1988
23
Toxic megacolon complicating Campylobacter enterocolitis. (3734370)
1986
24
Toxic megacolon due to Campylobacter colitis. (3598315)
1986
25
Toxic megacolon in typhoid fever. (4062466)
1985
26
Toxic megacolon: survival without colectomy (a case report). (6481659)
1984
27
Computerized tomographic demonstration of toxic megacolon: report of a case. (6641190)
1983
28
Toxic megacolon. (6842036)
1983
29
Clostridium difficile in toxic megacolon. (6814650)
1982
30
Clostridium difficile in toxic megacolon complicating acute inflammatory bowel disease. (6809132)
1982
31
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
32
Filiform polyposis in Crohn's colitis mimicking toxic megacolon. (7297374)
1981
33
Surgical treatment of toxic megacolon and proposal for a program of therapy. (7425218)
1980
34
Antibiotic-associated pseudomembranous colitis with toxic megacolon: two case reports in children. (7236136)
1980
35
Toxic megacolon in inflammatory bowel disease: a new perspective. (279946)
1978
36
Toxic megacolon--unusual complication of pseudomembranous colitis. (589788)
1977
37
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
38
Surgical management of toxic megacolon. (920716)
1977
39
Clindamycin associated pseudomembranous enterocolitis and toxic megacolon. (1245777)
1976
40
Treatment of toxic megacolon. (1251308)
1976
41
Toxic megacolon with perforation. Case report. (4746805)
1973
42
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
43
Toxic megacolon. A surgical disease. (5546331)
1971
44
Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. (5570601)
1971
45
Toxic megacolon. (5774994)
1969
46
Chronic ulcerative colitis complicated by toxic megacolon. (5922036)
1966
47
TOXIC MEGACOLON COMPLICATING CHRONIC ULCERATIVE COLITIS. (14315434)
1965
48
TOXIC MEGACOLON IN FULMINATING DISEASE. (14250072)
1965
49
Toxic megacolon syndrome of ulcerative colitis. (14007124)
1962
50
Toxic megacolon in ulcerative colitis. (14439404)
1959

Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Megacolon

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Pathways for genes affiliated with Toxic Megacolon

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Compounds for genes affiliated with Toxic Megacolon

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GO Terms for genes affiliated with Toxic Megacolon

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Products for genes affiliated with Toxic Megacolon

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Megacolon

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet