MCID: TXC001
MIFTS: 39

Toxic Megacolon malady

Category: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

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Aliases & Descriptions for Toxic Megacolon:

Name: Toxic Megacolon 10 12
 
Megacolon, Toxic 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:1770
ICD1027 K59.3
SNOMED-CT59 28536002
MeSH36 D008532
UMLS65 C0025162

Summaries for Toxic Megacolon

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Wikipedia:68 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards based summary: Toxic Megacolon, also known as megacolon, toxic, is related to crohn's colitis and megacolon. An important gene associated with Toxic Megacolon is TMC1 (Transmembrane Channel Like 1), and among its related pathways is SIDS Susceptibility Pathways. Affiliated tissues include colon, prostate and endothelial, and related mouse phenotypes are integument and digestive/alimentary.

Related Diseases for Toxic Megacolon

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Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1crohn's colitis30.7ATP12A, ATP4A
2megacolon30.5ATP12A, ATP4A, HTR7, NTS, TAC1
3diabetes mellitus, noninsulin-dependent, 510.8EDNRB, RET
4pericholangitis10.8ALB, CRP
5colitis10.8
6calpainopathy10.7ALB, CRP
7askin's tumor10.7ALB, CRP
8thrombophlebitis migrans10.7ALB, CRP
9bacterial gastritis10.7ALB, ATP4A
10cervical wilms' tumor10.7CRP, IL1RN
11anuria10.7EDNRB, HTR7
12fallopian tube carcinoma10.6CRP, HSPD1
13hemopericardium10.6ALB, IL1RN
14black piedra10.6ALB, ATP4A
15intracranial embolism10.6CRP, IL1RN
16pulmonary aspergilloma10.6ALB, ATP4A, CRP
17peripheral nervous system disease10.6CRP, HSPD1
18ulcerative colitis10.6
19anotia10.6CRP, IL18
20commensal bacterial infectious disease10.5ALB, CRP, HSPD1
21pneumoconiosis10.5ALB, CRP, HSPD1
22rhinoscleroma10.5CRP, LYZ
23peripheral artery disease10.5ALB, CRP, IL1RN
24diamond-blackfan anemia 110.5ALB, CRP, HSPD1
25bacterial esophagitis10.5IL1RN, RET
26abducens nerve neoplasm10.5CRP, LYZ
27hepatic vein thrombosis10.5ATP12A, ATP4A
28ossifying fibroma10.5ALB, CRP, LYZ
29phlebotomus fever10.5ATP12A, ATP4A
30venezuelan equine encephalitis10.5ATP12A, ATP4A
31subareolar duct papillomatosis10.4ATP12A, ATP4A
32mononeuritis of lower limb10.4ALB, CRP, LYZ
33acute cystitis10.4ATP12A, ATP4A
34acute allergic mucoid otitis media10.4CRP, CTSL, LYZ
35epiglottitis10.4ATP12A, ATP4A
36cataract10.4CRP, IL1RN
37duodenal disease10.4ATP4A, NTS
38toxicodendron dermatitis10.4ATP12A, ATP4A
39pericardial effusion10.4ATP12A, ATP4A
40acute chest syndrome10.4ATP12A, ATP4A
41duodenal obstruction10.4ATP12A, ATP4A
42krukenberg carcinoma10.4ATP12A, ATP4A
43in situ carcinoma10.4ALB, CRP
44accessory nerve disease10.4CRP, HSPD1, IL1RN
45ureteral disease10.3CRP, IL18, IL1RN
46prostate carcinoma in situ10.3ATP12A, ATP4A
47diffuse scleroderma10.3ALB, CRP, TAC1
48heart disease10.3ALB, CRP, IL1RN, RET
49uterine corpus epithelioid leiomyosarcoma10.3ALB, CRP, TAC1
50goodpasture syndrome10.3ALB, CRP

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Symptoms for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinapprovedPhase 4, Phase 2, Phase 33051404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
LS-161387
 
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin Hydrochloride
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2Anti-Bacterial AgentsPhase 4, Phase 2, Phase 39140
3Anti-Infective AgentsPhase 4, Phase 2, Phase 317220
4
MetronidazoleapprovedPhase 2, Phase 3418443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
Metric
Metric 21
Metro Cream
Metro Gel
 
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrocream
Metrodzhil
Metrogel
Metrogel-vaginal
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolotion
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole Topical Gel
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole hydrochloride
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosadan
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
5LaxativesPhase 2, Phase 3344
6Polyethylene glycol 3350Phase 2, Phase 390
7Gastrointestinal AgentsPhase 2, Phase 36401
8CatharticsPhase 2, Phase 3344
9Antiprotozoal AgentsPhase 2, Phase 31730
10Antibiotics, AntitubercularPhase 2, Phase 35971
11Antiparasitic AgentsPhase 2, Phase 31854
12Antibodies4477
13Immunoglobulins4477
14ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsNot yet recruitingNCT02466698Phase 2, Phase 3
3Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
4Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809
5Host Immune Response to Clostridium Difficile InfectionRecruitingNCT02440438

Search NIH Clinical Center for Toxic Megacolon


Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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MalaCards organs/tissues related to Toxic Megacolon:

33
Colon, Prostate, Endothelial, Bone, Heart, B cells, Breast

Animal Models for Toxic Megacolon or affiliated genes

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MGI Mouse Phenotypes related to Toxic Megacolon:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0EDNRB, HTR7, IL18, IL1RN, LYZ, PFAS
2MP:00053817.9ALB, ATP12A, ATP4A, EDNRB, IL18, LYZ
3MP:00053766.5ALB, ATP12A, ATP4A, CRP, EDNRB, FLOT2
4MP:00053866.3EDNRB, FLOT2, HSPD1, HTR7, IL18, LYZ

Publications for Toxic Megacolon

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Articles related to Toxic Megacolon:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Toxic Megacolon: A Review for Emergency Department Clinicians. (27185628)
2016
2
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
3
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
4
Toxic megacolon. (22009735)
2012
5
Toxic megacolon due to fulminant Clostridium Difficile colitis. (21861326)
2011
6
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. (22242068)
2010
7
Ulcerative colitis presenting as toxic megacolon. (21189707)
2010
8
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. (19899041)
2010
9
Toxic megacolon secondary to Clostridium difficile colitis. Case report. (20423791)
2010
10
Management of acute colitis and toxic megacolon. (22131898)
2010
11
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
12
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
13
Invasive aspergillosis localised to the colon presenting as toxic megacolon. (17328784)
2007
14
A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates. (17671768)
2007
15
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
16
Early surgery for the treatment of toxic megacolon. (16172551)
2005
17
Inflammatory pseudopolyposis in a patient with toxic megacolon due to pseudomembranous colitis. (11757676)
2001
18
Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon. (11144376)
2000
19
Sub-total colectomy for perforated toxic megacolon in pregnancy. (15512196)
1998
20
Antibiotic-associated fulminant pseudomembranous colitis without toxic megacolon. (1449149)
1992
21
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
22
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
23
Toxic megacolon and perforation caused by Salmonella. (2765830)
1989
24
Toxic megacolon presenting in the leukocyte scan as distended transverse bowel. (3130613)
1988
25
Toxic megacolon complicating Campylobacter enterocolitis. (3734370)
1986
26
Toxic megacolon due to Campylobacter colitis. (3598315)
1986
27
Toxic megacolon in typhoid fever. (4062466)
1985
28
Toxic megacolon: survival without colectomy (a case report). (6481659)
1984
29
Computerized tomographic demonstration of toxic megacolon: report of a case. (6641190)
1983
30
Toxic megacolon. (6842036)
1983
31
Clostridium difficile in toxic megacolon. (6814650)
1982
32
Clostridium difficile in toxic megacolon complicating acute inflammatory bowel disease. (6809132)
1982
33
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
34
Filiform polyposis in Crohn's colitis mimicking toxic megacolon. (7297374)
1981
35
Surgical treatment of toxic megacolon and proposal for a program of therapy. (7425218)
1980
36
Antibiotic-associated pseudomembranous colitis with toxic megacolon: two case reports in children. (7236136)
1980
37
Toxic megacolon in inflammatory bowel disease: a new perspective. (279946)
1978
38
Toxic megacolon--unusual complication of pseudomembranous colitis. (589788)
1977
39
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
40
Surgical management of toxic megacolon. (920716)
1977
41
Clindamycin associated pseudomembranous enterocolitis and toxic megacolon. (1245777)
1976
42
Treatment of toxic megacolon. (1251308)
1976
43
Toxic megacolon with perforation. Case report. (4746805)
1973
44
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
45
Toxic megacolon. A surgical disease. (5546331)
1971
46
Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. (5570601)
1971
47
Toxic megacolon. (5774994)
1969
48
TOXIC MEGACOLON COMPLICATING CHRONIC ULCERATIVE COLITIS. (14315434)
1965
49
TOXIC MEGACOLON IN FULMINATING DISEASE. (14250072)
1965
50
Toxic megacolon syndrome of ulcerative colitis. (14007124)
1962

Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for genes affiliated with Toxic Megacolon

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Pathways related to Toxic Megacolon according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1HSPD1, IL1RN, RET, TAC1

GO Terms for genes affiliated with Toxic Megacolon

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Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1posterior midgut developmentGO:000749710.5EDNRB, RET
2cellular response to nerve growth factor stimulusGO:19900909.7NTS, TAC1
3regulation of pHGO:00068859.6ATP12A, EDNRB
4positive regulation of renal sodium excretionGO:00358159.6EDNRB, TAC1
5potassium ion importGO:00101079.3ATP12A, ATP4A

Sources for Toxic Megacolon

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet