MCID: TXC001
MIFTS: 28

Toxic Megacolon

Categories: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

MalaCards integrated aliases for Toxic Megacolon:

Name: Toxic Megacolon 12 14
Megacolon, Toxic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1770
ICD10 33 K59.3
MeSH 42 D008532
SNOMED-CT 64 28536002
UMLS 69 C0025162

Summaries for Toxic Megacolon

MalaCards based summary : Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and colitis. An important gene associated with Toxic Megacolon is TMC1 (Transmembrane Channel Like 1). The drugs Vancomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, myeloid and smooth muscle.

Wikipedia : 72 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

Related Diseases for Toxic Megacolon

Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 megacolon 10.8
2 colitis 10.6
3 ulcerative colitis 10.5
4 crohn's disease 10.2
5 clostridium difficile colitis 10.1
6 inflammatory bowel disease 10.0
7 cytomegalovirus infection 10.0
8 crohn's colitis 10.0
9 polysyndactyly with cardiac malformation 9.9 ALB ATP4A
10 diarrhea 9.9
11 chronic gonococcal salpingitis 9.9 ALB ATP4A
12 hemopericardium 9.9 ALB EDNRB
13 cryptogenic organizing pneumonia 9.9 ALB ATP4A
14 angelucci's syndrome 9.8 ALB ATP4A
15 cervix uteri carcinoma in situ 9.8 ALB EDNRB
16 gastroenteritis 9.8
17 ischemic colitis 9.8
18 collagenous colitis 9.8
19 compartment syndrome 9.8
20 thrombosis 9.8
21 amyloidosis 9.8
22 disseminated intravascular coagulation 9.8
23 leukemia 9.8
24 pediatric infratentorial ependymoblastoma 9.7 ALB ATP4A
25 esophageal leukoplakia 9.7 ALB EDNRB
26 typhoid fever 9.7
27 lymphoma 9.7
28 intestinal perforation 9.7
29 ischemia 9.7
30 endophthalmitis 9.7
31 pneumonia 9.7
32 aspergillosis 9.7
33 salmonellosis 9.7
34 diverticulitis 9.7
35 duchenne muscular dystrophy 9.7
36 neuronitis 9.7
37 burns 9.7
38 lymphoblastic leukemia 9.7
39 chorioretinitis 9.7
40 sarcoma 9.7
41 hepatitis 9.7
42 amebiasis 9.7
43 muscular dystrophy 9.7
44 spinal cord injury 9.7
45 dysentery 9.7
46 al amyloidosis 9.7
47 shigellosis 9.7
48 retroperitoneal fibrosis 9.7
49 invasive aspergillosis 9.7
50 endometrial clear cell adenocarcinoma 9.5 ALB EDNRB

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to Toxic Megacolon

Symptoms & Phenotypes for Toxic Megacolon

Drugs & Therapeutics for Toxic Megacolon

Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 2,Phase 3 1404-90-6 441141 14969
2 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
3 Anti-Infective Agents Phase 4,Phase 2,Phase 3
4
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
5 Antibiotics, Antitubercular Phase 2, Phase 3
6 Antiparasitic Agents Phase 2, Phase 3
7 Antiprotozoal Agents Phase 2, Phase 3
8 Antitubercular Agents Phase 2, Phase 3
9 Cathartics Phase 2, Phase 3
10 Gastrointestinal Agents Phase 2, Phase 3
11 Laxatives Phase 2, Phase 3
12 Polyethylene glycol 3350 Phase 2, Phase 3
13 Antibodies
14 Immunoglobulins
15 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
2 Intestinal Lavage for the Treatment of Severe C. Difficile Infections Recruiting NCT02466698 Phase 2, Phase 3 Vancomycin;PEG;Metronidazole
3 Host Immune Response to Clostridium Difficile Infection (ICD) Completed NCT02440438
4 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Recruiting NCT01959048 fecal microbiota transplantation
5 Genetic Mosaicism in Hirschsprung's Disease Recruiting NCT01927809

Search NIH Clinical Center for Toxic Megacolon

Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

Anatomical Context for Toxic Megacolon

MalaCards organs/tissues related to Toxic Megacolon:

39
Colon, Myeloid, Smooth Muscle, Heart, Bone, Spinal Cord, Bone Marrow

Publications for Toxic Megacolon

Articles related to Toxic Megacolon:

(show top 50) (show all 242)
id Title Authors Year
1
Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report. ( 28403672 )
2017
2
Toxic Megacolon: A Review for Emergency Department Clinicians. ( 27185628 )
2016
3
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. ( 28090493 )
2016
4
Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon. ( 28097034 )
2016
5
Campylobacter colitis: Rare cause of toxic megacolon. ( 27614338 )
2016
6
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. ( 26943694 )
2016
7
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. ( 27281569 )
2016
8
Fatal Toxic Megacolon in a Child of Hirschsprung Disease. ( 28208866 )
2016
9
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. ( 26181500 )
2015
10
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. ( 25942309 )
2015
11
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. ( 25866348 )
2015
12
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. ( 25721003 )
2015
13
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. ( 26202312 )
2015
14
Toxic megacolon during pregnancy in ulcerative colitis: A case report. ( 25942749 )
2015
15
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. ( 24858336 )
2014
16
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. ( 24755987 )
2014
17
Toxic megacolon after abdominoplasty: a case report. ( 24667886 )
2014
18
Surgical Management of Toxic Megacolon. ( 26176049 )
2014
19
Toxic megacolon complicating a first course of Crohn's disease: about two cases. ( 24765512 )
2013
20
Unusual Complication of Toxic Megacolon in Typhoid Colitis. ( 23900751 )
2013
21
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. ( 24163654 )
2013
22
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. ( 24351341 )
2013
23
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. ( 22923362 )
2013
24
"Ulcerative crepitus" -- a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively. ( 22398071 )
2012
25
Fulminant Clostridium difficile toxic megacolon in a pediatric heart transplant recipient. ( 20887401 )
2012
26
Infliximab in Crohn's disease-associated toxic megacolon. ( 21857531 )
2012
27
Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naA^ve ulcerative colitis. ( 23037465 )
2012
28
Impending megacolon: small bowel distension as a predictor of toxic megacolon in ulcerative colitis. ( 22843318 )
2012
29
Toxic megacolon from sexually transmitted Shigella sonnei infection. ( 21538050 )
2012
30
Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazine. ( 22878997 )
2012
31
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. ( 22726419 )
2012
32
Toxic megacolon. ( 22009735 )
2012
33
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. ( 21859335 )
2011
34
Toxic megacolon due to fulminant Clostridium Difficile colitis. ( 21861326 )
2011
35
Toxic megacolon with abdominal compartment syndrome. ( 21825926 )
2011
36
Toxic megacolon in patients with severe acute colitis: computed tomographic features. ( 22040786 )
2011
37
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. ( 22242068 )
2010
38
Endoscopic findings of intestinal BehAset's disease complicated with toxic megacolon. ( 20556721 )
2010
39
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. ( 19745034 )
2010
40
Cytomegalovirus infection in patients who required colectomy for toxic megacolon or severe steroid-refractory ulcerative colitis. ( 20094780 )
2010
41
Toxic megacolon secondary to Clostridium difficile colitis. Case report. ( 20423791 )
2010
42
Management of acute colitis and toxic megacolon. ( 22131898 )
2010
43
Ulcerative colitis presenting as toxic megacolon. ( 21189707 )
2010
44
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. ( 19899041 )
2010
45
Toxic megacolon associated Clostridium difficile colitis. ( 21160629 )
2010
46
Splenic rupture secondary to venous thrombosis in a patient with ulcerative colitis and toxic megacolon. ( 21457644 )
2010
47
Rotavirus gastroenteritis complicated with toxic megacolon. ( 19650837 )
2009
48
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. ( 19821211 )
2009
49
A case of toxic megacolon in a patient with collagenous colitis. ( 19484403 )
2009
50
Non-toxic megacolon due to transverse and sigmoid colon volvulus in a patient with ulcerative colitis. ( 21172246 )
2009

Variations for Toxic Megacolon

Expression for Toxic Megacolon

Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for Toxic Megacolon

GO Terms for Toxic Megacolon

Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 8.92 ABCB6 ALB ATP4A TMC1

Sources for Toxic Megacolon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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