MCID: TXC001
MIFTS: 26

Toxic Megacolon malady

Category: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

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Aliases & Descriptions for Toxic Megacolon:

Name: Toxic Megacolon 11 13
 
Megacolon, Toxic 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:1770
ICD1028 K59.3
SNOMED-CT60 28536002
MeSH37 D008532

Summaries for Toxic Megacolon

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Wikipedia:69 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards based summary: Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and colitis. An important gene associated with Toxic Megacolon is TMC1 (Transmembrane Channel Like 1). Affiliated tissues include colon, myeloid and smooth muscle.

Related Diseases for Toxic Megacolon

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Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Symptoms for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinPhase 4, Phase 2, Phase 33161404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
 
LS-161387
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2
MetronidazolePhase 2, Phase 3438443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
 
Metric
Metric 21
Metro Cream
Metro Gel
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrodzhil
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
3COLANutraceutical1824

Interventional clinical trials:

idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsRecruitingNCT02466698Phase 2, Phase 3
3Host Immune Response to Clostridium Difficile Infection (ICD)CompletedNCT02440438
4Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
5Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809

Search NIH Clinical Center for Toxic Megacolon


Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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MalaCards organs/tissues related to Toxic Megacolon:

34
Colon, Myeloid, Smooth muscle, Heart, Bone, Spinal cord, Bone marrow

Animal Models for Toxic Megacolon or affiliated genes

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Publications for Toxic Megacolon

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Articles related to Toxic Megacolon:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
2
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. (24755987)
2014
3
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
4
Toxic megacolon complicating a first course of Crohn's disease: about two cases. (24765512)
2013
5
Toxic megacolon due to fulminant Clostridium Difficile colitis. (21861326)
2011
6
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. (19745034)
2010
7
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
8
Toxic megacolon in children with inflammatory bowel disease: clinical and radiographic characteristics. (18510624)
2008
9
Invasive aspergillosis localised to the colon presenting as toxic megacolon. (17328784)
2007
10
A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates. (17671768)
2007
11
Toxic megacolon complicating Escherichia coli O157 infection. (16126276)
2006
12
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
13
Surgical management of acute colitis and toxic megacolon. (20011287)
2004
14
Toxic megacolon associated with cytomegalovirus infection in ulcerative colitis. (14673733)
2003
15
A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management. (14638335)
2003
16
Hyperbaric oxygen for toxic megacolon. (10023977)
1999
17
Bilateral endogenous Candida endophthalmitis and chorioretinitis following toxic megacolon. (9091381)
1996
18
Crohn's disease presenting as toxic megacolon in an elderly man. (8588782)
1995
19
Etiology and management of toxic megacolon in patients with human immunodeficiency virus infection. (8076773)
1994
20
Pseudomembranous colitis leading to toxic megacolon associated with antineoplastic chemotherapy. Report of a case and review of the literature. (1582360)
1992
21
Salmonellosis: a cause of toxic megacolon. (2398260)
1990
22
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
23
Toxic megacolon and perforation caused by Salmonella. (2765830)
1989
24
Toxic megacolon due to Campylobacter colitis. (3598331)
1987
25
Toxic megacolon due to Campylobacter colitis. (3598315)
1986
26
Toxic megacolon in typhoid fever. (4062466)
1985
27
Toxic megacolon: survival without colectomy (a case report). (6481659)
1984
28
Gallium-67 citrate scintigraphy in toxic megacolon. (6589103)
1984
29
Computerized tomographic demonstration of toxic megacolon: report of a case. (6641190)
1983
30
Toxic megacolon after proctosigmoidoscopy in ulcerative colitis. (6879284)
1983
31
Clostridium difficile in toxic megacolon. (6814650)
1982
32
Clostridium difficile in toxic megacolon complicating acute inflammatory bowel disease. (6809132)
1982
33
Clostridium difficile in toxic megacolon. (6811052)
1982
34
Toxic megacolon. Part I: Pathogenesis, diagnosis and treatment. (6265121)
1981
35
Toxic megacolon in ulcerative colitis: a continuing challenge. (7291100)
1981
36
Fatal Shigella dysentery complicated by toxic megacolon and bone marrow aplasia in a patient with chronic granulocytic leukemia in remission. (7009362)
1980
37
Toxic megacolon. (85062)
1979
38
Toxic megacolon associated with loperamide therapy. (759668)
1979
39
Toxic megacolon in inflammatory bowel disease: a new perspective. (279946)
1978
40
Treatment of toxic megacolon. A comparative review of 29 patients. (190879)
1977
41
Current surgical approach to toxic megacolon. (936046)
1976
42
Radiology of acute toxic megacolon. (4834610)
1974
43
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
44
Toxic megacolon. A surgical disease. (5546331)
1971
45
Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. (5570601)
1971
46
Choice of operation for the toxic megacolon phase of nonspecific ulcerative colitis. (4918890)
1970
47
Toxic megacolon. (5774994)
1969
48
Chronic ulcerative colitis complicated by toxic megacolon. (5922036)
1966
49
TOXIC MEGACOLON COMPLICATING CHRONIC ULCERATIVE COLITIS. (14315434)
1965
50
Toxic megacolon syndrome of ulcerative colitis. (14007124)
1962

Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for genes affiliated with Toxic Megacolon

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GO Terms for genes affiliated with Toxic Megacolon

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Sources for Toxic Megacolon

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet