MCID: TXC001
MIFTS: 29

Toxic Megacolon malady

Summaries for Toxic Megacolon

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63Wikipedia, 32MalaCards
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Wikipedia:63 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards: Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and ulcerative colitis. An important gene associated with Toxic Megacolon is PFAS (phosphoribosylformylglycinamidine synthase). Affiliated tissues include colon, bone marrow and bone, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Toxic Megacolon

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

toxic megacolon 8 10
megacolon, toxic 60


External Ids:

Disease Ontology8 DOID:1770
SNOMED-CT56 28536002
MeSH34 D008532

Related Diseases for Toxic Megacolon

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17GeneCards, 18GeneDecks
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Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1megacolon11.2
2ulcerative colitis10.9
3crohn's disease10.5
4inflammatory bowel disease10.3
5diarrhea10.3
6amyloidosis10.2
7compartment syndrome10.2
8disseminated intravascular coagulation10.2
9gastroenteritis10.2
10burns10.0
11colon lymphoma10.0
12amebiasis10.0
13kaposi's sarcoma10.0
14diverticulitis of colon10.0
15typhoid fever10.0
16shigellosis10.0
17invasive aspergillosis10.0
18aspergillosis10.0
19chorioretinitis10.0
20colonic disease10.0
21diverticulitis10.0
22dysentery10.0
23endophthalmitis10.0
24hepatitis10.0
25intestinal disease10.0
26intestinal perforation10.0
27ischemia10.0
28leukemia10.0
29sarcoma10.0

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Clinical Features for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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32MalaCards
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MalaCards organs/tissues related to Toxic Megacolon:

32
Colon, Bone marrow, Bone, Spinal cord, Heart, Smooth muscle, Myeloid

Animal Models for Toxic Megacolon or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Toxic Megacolon:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0TMC1, PFAS
2MP:00053918.7TMC1, PFAS

Publications for Toxic Megacolon

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50PubMed
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Articles related to Toxic Megacolon:

(show top 50)    (show all 224)
idTitleAuthorsYear
1
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. (24351341)
2013
2
Toxic megacolon from sexually transmitted Shigella sonnei infection. (21538050)
2012
3
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. (21859335)
2011
4
Ulcerative colitis presenting as toxic megacolon. (21189707)
2010
5
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. (19899041)
2010
6
Collagenous colitis as a possible cause of toxic megacolon. (18584272)
2009
7
Non-toxic megacolon due to transverse and sigmoid colon volvulus in a patient with ulcerative colitis. (21172246)
2009
8
A case of toxic megacolon secondary to Clostridium difficile-associated diarrhea worsened after administration of an antimotility agent and molecular analysis of recovered isolates. (17671768)
2007
9
Toxic megacolon complicating Escherichia coli O157 infection. (16126276)
2006
10
Colostomy with vancomycin administration as an effective treatment for toxic megacolon associated with fulminant pseudomembranous colitis: a case report. (15564168)
2004
11
Toxic megacolon: remember cytomegalovirus. (11291471)
2001
12
Factors associated with intestinal perforation in children's non-typhi Salmonella toxic megacolon. (11144376)
2000
13
Toxic megacolon secondary to infective colitis in children. (10820951)
2000
14
Imipramine overdose complicated by toxic megacolon. (9520815)
1998
15
Clostridium difficile toxic megacolon following splenectomy. (9403828)
1997
16
Bilateral endogenous Candida endophthalmitis and chorioretinitis following toxic megacolon. (9091381)
1996
17
Toxic megacolon complicating pseudomembranous enterocolitis. (7555415)
1995
18
Etiology and management of toxic megacolon in patients with human immunodeficiency virus infection. (8076773)
1994
19
A case of toxic megacolon in ulcerative colitis associated with cytomegalovirus infection. (7951862)
1994
20
Antibiotic-associated pseudomembranous colitis with toxic megacolon after cesarean section. (8426456)
1993
21
Toxic megacolon associated with anticancer chemotherapy. (1651153)
1991
22
Toxic megacolon and perforation caused by Salmonella. (2302504)
1990
23
Toxic megacolon (TM) due to Salmonella. (2230011)
1990
24
Toxic megacolon and perforation caused by Shigella. (2688808)
1989
25
Toxic or non-toxic megacolon. (3730670)
1986
26
Toxic megacolon following spinal cord injury. (6542646)
1984
27
Toxic megacolon. (6842036)
1983
28
Toxic megacolon complicating pseudomembranous colitis. (6824883)
1983
29
The viewbox: toxic megacolon, amyloidosis, and analgesic-associated pseudo-obstruction. (6125492)
1982
30
Clostridium difficile in toxic megacolon. (6811052)
1982
31
Toxic megacolon secondary to pseudomembranous colitis. (7094787)
1982
32
Toxic megacolon developing in a patient with long-standing distal ulcerative colitis. (7270541)
1981
33
Antibiotic-associated pseudomembranous colitis with toxic megacolon: two case reports in children. (7236136)
1980
34
Fatal Shigella dysentery complicated by toxic megacolon and bone marrow aplasia in a patient with chronic granulocytic leukemia in remission. (7009362)
1980
35
Steroids and toxic megacolon. (422016)
1979
36
Toxic megacolon. (85062)
1979
37
Nursing care study: emergency colectomy for toxic megacolon. (85294)
1979
38
Diagnosis, surgical management and prognosis of toxic megacolon, a complication of ulcerative colitis. (866982)
1977
39
Treatment of toxic megacolon. (1251308)
1976
40
Toxic megacolon of ulcerative colitis in infancy. (934754)
1976
41
Editorial: Toxic megacolon may complicate Crohn's disease. (1174868)
1975
42
Radiology of acute toxic megacolon. (4834610)
1974
43
Toxic megacolon with perforation. Case report. (4746805)
1973
44
BehAset's syndrome, Crohn's disease and toxic megacolon. (4624700)
1972
45
Toxic megacolon. A surgical disease. (5546331)
1971
46
Toxic megacolon complicating Crohn's disease of the colon. (5456393)
1970
47
Toxic dilatation of colon (toxic megacolon): etiology, treatment and prognosis in 42 patients. (5769743)
1969
48
Current surgical aspects of toxic megacolon. (5765362)
1969
49
Toxic megacolon in pregnancy. (5361085)
1969
50
Toxic megacolon in amebic colitis. Report of a case. (6016044)
1967

Genetic Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Megacolon

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Pathways for genes affiliated with Toxic Megacolon

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Compounds for genes affiliated with Toxic Megacolon

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GO Terms for genes affiliated with Toxic Megacolon

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Products for genes affiliated with Toxic Megacolon

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Megacolon

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet