MCID: TXC001
MIFTS: 28

Toxic Megacolon malady

Category: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

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Aliases & Descriptions for Toxic Megacolon:

Name: Toxic Megacolon 11 13
 
Megacolon, Toxic 39 68

Classifications:



External Ids:

Disease Ontology11 DOID:1770
ICD1030 K59.3
SNOMED-CT62 28536002
MeSH39 D008532

Summaries for Toxic Megacolon

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Wikipedia:71 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards based summary: Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and colitis. An important gene associated with Toxic Megacolon is TMC1 (Transmembrane Channel Like 1). Affiliated tissues include colon, myeloid and smooth muscle.

Related Diseases for Toxic Megacolon

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Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Symptoms & Phenotypes for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinapprovedPhase 4, Phase 2, Phase 33321404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
 
LS-161387
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2Anti-Bacterial AgentsPhase 4, Phase 2, Phase 311226
3Anti-Infective AgentsPhase 4, Phase 2, Phase 322062
4
MetronidazoleapprovedPhase 2, Phase 3486443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
 
Metric
Metric 21
Metro Cream
Metro Gel
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrodzhil
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
5Gastrointestinal AgentsPhase 2, Phase 38402
6Polyethylene glycol 3350Phase 2, Phase 396
7LaxativesPhase 2, Phase 3537
8CatharticsPhase 2, Phase 3537
9Antitubercular AgentsPhase 2, Phase 31343
10Antiparasitic AgentsPhase 2, Phase 32199
11Antibiotics, AntitubercularPhase 2, Phase 37180
12Antiprotozoal AgentsPhase 2, Phase 32051
13Immunoglobulins6394
14Antibodies6394
15ColaNutraceutical1946

Interventional clinical trials:

idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsRecruitingNCT02466698Phase 2, Phase 3
3Host Immune Response to Clostridium Difficile Infection (ICD)CompletedNCT02440438
4Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
5Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809

Search NIH Clinical Center for Toxic Megacolon


Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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MalaCards organs/tissues related to Toxic Megacolon:

36
Colon, Myeloid, Smooth muscle, Heart, Bone, Spinal cord, Bone marrow

Publications for Toxic Megacolon

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Articles related to Toxic Megacolon:

(show top 50)    (show all 239)
idTitleAuthorsYear
1
Toxic Megacolon: A Review for Emergency Department Clinicians. (27185628)
2016
2
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. (27281569)
2016
3
Toxic megacolon and interstitial pneumonia caused by cytomegalovirus infection in a pediatric patient with acute lymphoblastic leukemia receiving chemotherapy. (28090493)
2016
4
Induction of potentially lethal hypermagnesemia, ischemic colitis, and toxic megacolon by a preoperative mechanical bowel preparation: report of a case. (26943694)
2016
5
Campylobacter colitis: Rare cause of toxic megacolon. (27614338)
2016
6
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. (25942309)
2015
7
Toxic colonoscopy--how investigating active inflammatory bowel disease can lead to the serious complication of toxic megacolon. (26202312)
2015
8
A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation. (25721003)
2015
9
Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. (25866348)
2015
10
Toxic megacolon during pregnancy in ulcerative colitis: A case report. (25942749)
2015
11
The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease. (26181500)
2015
12
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. (24858336)
2014
13
Surgical Management of Toxic Megacolon. (26176049)
2014
14
Toxic megacolon in ulcerative rectocolitis. Current trends in clinical evaluation, diagnosis and treatment. (24755987)
2014
15
Toxic megacolon after abdominoplasty: a case report. (24667886)
2014
16
From impending toxic megacolon to multiple organ failure in severe ulcerative colitis. (22923362)
2013
17
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
18
Nonresectional surgical approach to toxic megacolon with abdominal compartment syndrome. (24351341)
2013
19
Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis. (24163654)
2013
20
Toxic megacolon complicating a first course of Crohn's disease: about two cases. (24765512)
2013
21
Toxic megacolon. (22009735)
2012
22
Conservative surgical treatment for toxic megacolon due to Clostridium difficile infection in a transplanted pediatric patient. (22726419)
2012
23
Infliximab in Crohn's disease-associated toxic megacolon. (21857531)
2012
24
Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazine. (22878997)
2012
25
Ulcerative crepitus" -- a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively. (22398071)
2012
26
Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naA^ve ulcerative colitis. (23037465)
2012
27
Fulminant Clostridium difficile toxic megacolon in a pediatric heart transplant recipient. (20887401)
2012
28
Impending megacolon: small bowel distension as a predictor of toxic megacolon in ulcerative colitis. (22843318)
2012
29
Toxic megacolon from sexually transmitted Shigella sonnei infection. (21538050)
2012
30
Toxic megacolon in patients with severe acute colitis: computed tomographic features. (22040786)
2011
31
Toxic megacolon with abdominal compartment syndrome. (21825926)
2011
32
Surgical outcome of community-acquired Clostridium difficile colitis presenting as toxic megacolon: case report. (21859335)
2011
33
Toxic megacolon due to fulminant Clostridium Difficile colitis. (21861326)
2011
34
Management of acute colitis and toxic megacolon. (22131898)
2010
35
Cytomegalovirus infection in patients who required colectomy for toxic megacolon or severe steroid-refractory ulcerative colitis. (20094780)
2010
36
Toxic megacolon secondary to Clostridium difficile colitis. Case report. (20423791)
2010
37
Toxic megacolon associated Clostridium difficile colitis. (21160629)
2010
38
Endoscopic findings of intestinal BehAset's disease complicated with toxic megacolon. (20556721)
2010
39
Toxic megacolon complicating a Clostridium difficile infection in a pregnant woman. (19745034)
2010
40
Colonic stricture and fistula following haemolytic uraemic syndrome with toxic megacolon. (19899041)
2010
41
Ulcerative colitis presenting as toxic megacolon. (21189707)
2010
42
Toxic megacolon from hypervirulent Clostridium difficile infection (ribotype 027) following elective total knee replacement: an emerging challenge in modern health care. (22242068)
2010
43
Splenic rupture secondary to venous thrombosis in a patient with ulcerative colitis and toxic megacolon. (21457644)
2010
44
Non-toxic megacolon due to transverse and sigmoid colon volvulus in a patient with ulcerative colitis. (21172246)
2009
45
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
46
Rotavirus gastroenteritis complicated with toxic megacolon. (19650837)
2009
47
Collagenous colitis as a possible cause of toxic megacolon. (18584272)
2009
48
A case of toxic megacolon in a patient with collagenous colitis. (19484403)
2009
49
The identification and treatment of toxic megacolon secondary to pseudomembranous colitis. (18953191)
2008
50
Defining surgical therapy for pseudomembranous colitis with toxic megacolon. (18277885)
2008

Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for genes affiliated with Toxic Megacolon

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GO Terms for genes affiliated with Toxic Megacolon

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Sources for Toxic Megacolon

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet