MCID: TXC001
MIFTS: 34

Toxic Megacolon malady

Category: Gastrointestinal diseases

Aliases & Classifications for Toxic Megacolon

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Aliases & Descriptions for Toxic Megacolon:

Name: Toxic Megacolon 10 12
 
Megacolon, Toxic 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:1770
ICD1027 K59.3
SNOMED-CT59 28536002
MeSH36 D008532
UMLS65 C0025162

Summaries for Toxic Megacolon

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Wikipedia:68 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards based summary: Toxic Megacolon, also known as megacolon, toxic, is related to pneumoconiosis and heart disease. An important gene associated with Toxic Megacolon is TMC1 (Transmembrane Channel Like 1), and among its related pathways is SIDS Susceptibility Pathways. Affiliated tissues include colon, bone and endothelial, and related mouse phenotypes are integument and digestive/alimentary.

Related Diseases for Toxic Megacolon

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Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis30.5ALB, CRP, HSPD1
2heart disease30.5ALB, CRP, IL1RN, RET
3venezuelan equine encephalitis30.4ATP12A, ATP4A
4cataract30.4CRP, IL1RN
5esophagitis30.2ATP12A, ATP4A, CRP
6diabetes mellitus, noninsulin-dependent, 510.5EDNRB, RET
7pericholangitis10.5ALB, CRP
8calpainopathy10.5ALB, CRP
9askin's tumor10.5ALB, CRP
10thrombophlebitis migrans10.5ALB, CRP
11bacterial gastritis10.5ALB, ATP4A
12cervical wilms' tumor10.4CRP, IL1RN
13anuria10.4EDNRB, HTR7
14fallopian tube carcinoma10.4CRP, HSPD1
15hemopericardium10.4ALB, IL1RN
16black piedra10.4ALB, ATP4A
17intracranial embolism10.4CRP, IL1RN
18pulmonary aspergilloma10.4ALB, ATP4A, CRP
19peripheral nervous system disease10.4CRP, HSPD1
20anotia10.4CRP, IL18
21commensal bacterial infectious disease10.4ALB, CRP, HSPD1
22rhinoscleroma10.3CRP, LYZ
23peripheral artery disease10.3ALB, CRP, IL1RN
24diamond-blackfan anemia 110.3ALB, CRP, HSPD1
25bacterial esophagitis10.3IL1RN, RET
26endotheliitis10.3
27abducens nerve neoplasm10.3CRP, LYZ
28hepatic vein thrombosis10.3ATP12A, ATP4A
29ossifying fibroma10.3ALB, CRP, LYZ
30phlebotomus fever10.3ATP12A, ATP4A
31subareolar duct papillomatosis10.3ATP12A, ATP4A
32mononeuritis of lower limb10.3ALB, CRP, LYZ
33acute cystitis10.3ATP12A, ATP4A
34acute allergic mucoid otitis media10.3CRP, CTSL, LYZ
35epiglottitis10.3ATP12A, ATP4A
36duodenal disease10.3ATP4A, NTS
37crohn's colitis10.3ATP12A, ATP4A
38toxicodendron dermatitis10.3ATP12A, ATP4A
39pericardial effusion10.3ATP12A, ATP4A
40acute chest syndrome10.3ATP12A, ATP4A
41breast cancer10.3
42lymphoma10.3
43thyroiditis10.3
44neuropathy10.3
45duodenal obstruction10.3ATP12A, ATP4A
46krukenberg carcinoma10.3ATP12A, ATP4A
47in situ carcinoma10.2ALB, CRP
48accessory nerve disease10.2CRP, HSPD1, IL1RN
49ureteral disease10.2CRP, IL18, IL1RN
50prostate carcinoma in situ10.2ATP12A, ATP4A

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Symptoms for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Drugs for Toxic Megacolon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VancomycinapprovedPhase 4, Phase 2, Phase 33051404-90-6441141, 14969
Synonyms:
(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-Oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
(2.2Sp,3.5sa,2.6sp)-O(4.2),C(3.4):c(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]
1404-90-6
1404-93-9 (hydrochloride)
64685-75-2 (sulfate)
AC1L24VU
AC1L9AMI
AC1Q29OH
BIDD:GT0353
C06689
C66H75Cl2N9O24
CHEBI:28001
CHEMBL262777
CID14969
CID441141
CID5311496
CID6426898
CID6917992
D00212
DB00512
EINECS 215-772-6
HSDB 3262
LMPK14000004
LS-161387
 
Lopac0_001267
MolPort-001-794-649
NCGC00162383-02
Prestwick0_000497
Prestwick1_000497
Prestwick2_000497
SPBio_002314
UNII-6Q205EH1VU
VAN
VANCOMYCIN
Vancocin
Vancocin (TN)
Vancocin HCL
Vancomicina
Vancomicina [INN-Spanish]
Vancomycin
Vancomycin (USP)
Vancomycin HCL
Vancomycin Hydrochloride
Vancomycin [USAN:INN:BAN]
Vancomycine
Vancomycine [INN-French]
Vancomycinum
Vancomycinum [INN-Latin]
nchembio.350-comp1
2Anti-Bacterial AgentsPhase 4, Phase 2, Phase 39140
3Anti-Infective AgentsPhase 4, Phase 2, Phase 317220
4
MetronidazoleapprovedPhase 2, Phase 3418443-48-14173
Synonyms:
1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole
1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole
1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole
1-(β-ethylol)-2-methyl-5-nitro-3-azapyrrole
1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole
1-(β-oxyethyl)-2-methyl-5-nitroimidazole
1-Hydroxyethyl-2-methyl-5-nitroimidazole
2-(2-methyl-5-nitroimidazol-1-yl)ethanol
2-Methyl-5-nitro-1-imidazoleethanol
2-Methyl-5-nitroimidazole-1-ethanol
2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole
2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole
2-methyl-5-nitroimidazole-1-ethanol
443-48-1
46461_FLUKA
46461_RIEDEL
69198-10-3 (mono-hydrochloride)
99616-64-5
AB00052046
AC-10556
AC1L1HKS
AC1Q2P2Z
AKOS000269646
APMN
ARONIS24285
Acromona
Anagiardil
Apo-Metronidazole
Arilin
Atrivyl
BAS 02983617
BAY-5360
BCBcMAP01_000184
BIDD:GT0107
BPBio1_000004
BRD-K52020312-001-05-2
BRN 0611683
BSPBio_000002
BSPBio_002031
Bayer 5360
Bexon
Bio-0694
CAS-443-48-1
CB-01-14 MMX
CCRIS 410
CHEBI:39845
CHEBI:6909
CHEMBL137
CID4173
CONT
CPD000058175
Caswell No. 579AA
Clont
D00409
DB00916
Danizol
Deflamon
Deflamon-wirkstoff
DivK1c_000007
EINECS 207-136-1
EPA Pesticide Chemical Code 120401
Efloran
Elyzol
Entizol
Eumin
FLAGYL I.V. RTU IN PLASTIC CONTAINER
Flagemona
Flagesol
Flagil
Flagyl
Flagyl (TN)
Flagyl 375
Flagyl Er
Flagyl I.V.
Flagyl I.V. RTU
Flegyl
Florazole
Fossyol
Giatricol
Ginefla vir
Gineflavir
HMS1568A04
HMS1920N19
HMS2051G07
HMS2090B19
HMS2091F14
HMS500A09
HMS547C19
HSDB 3129
I14-0667
IDI1_000007
IDR-90105
KBio1_000007
KBio2_001515
KBio2_004083
KBio2_006651
KBio3_001531
KBioGR_000559
KBioSS_001515
Klion
Klont
LS-1264
M0924
M1547_SIGMA
M3761_FLUKA
M3761_SIGMA
M9036_SIGMA
METRO I.V
METRONIDAZOLE USP
MLS000028590
MLS000758286
Maybridge1_001999
Meronidal
Methronidazole
Methyl-5-nitroimidazole-1-ethanol
Metric
Metric 21
Metro Cream
Metro Gel
 
Metro I.V.
Metro I.V. In Plastic Container
MetroCream
MetroGel
MetroGel-Vaginal
MetroLotion
Metrocream
Metrodzhil
Metrogel
Metrogel-vaginal
Metrogel-vaginal (TN)
Metrogyl
Metrolag
Metrolotion
Metrolyl
Metromidol
Metronidaz
Metronidazol
Metronidazol [INN-Spanish]
Metronidazole
Metronidazole (JP15/USP/INN)
Metronidazole Benzoate
Metronidazole Monohydrochloride
Metronidazole Phosphoester
Metronidazole Topical Gel
Metronidazole [USAN:INN:BAN:JAN]
Metronidazole hydrochloride
Metronidazole in Plastic Container
Metronidazolo
Metronidazolo [DCIT]
Metronidazolum
Metronidazolum [INN-Latin]
Metrotop
Metrozine
Metryl
Mexibol
Mexibol 'silanes'
MolPort-000-141-892
MolPort-002-502-101
Monagyl
Monasin
NCGC00016446-01
NCGC00016446-02
NCGC00022059-03
NCGC00022059-04
NCGC00022059-05
NCIOpen2_000337
NIDA
NINDS_000007
NSC 50364
NSC 69587
NSC-50364
NSC50364
NSC69587
Nalox
Nidagel
Noritate
Noritate (TN)
Novonidazol
Orvagil
Prestwick0_000081
Prestwick1_000081
Prestwick2_000081
Prestwick3_000081
Prestwick_334
Protostat
RP 8823
RP-8823
Rathimed
Rosadan
Rosased
S1907_Selleck
SAM001247010
SBB041018
SC 10295
SMP1_000189
SMR000058175
SPBio_000666
SPBio_001941
SPECTRUM1500412
STK177359
Sanatrichom
Satric
Spectrum2_000883
Spectrum3_000506
Spectrum4_000060
Spectrum5_001289
Spectrum_001035
Takimetol
Trichazol
Trichex
Tricho cordes
Tricho-gynaedron
Trichocide
Trichomol
Trichomonacid 'pharmachim'
Trichopal
Trichopol
Tricocet
Tricom
Tricowas B
Trikacide
Trikamon
Trikojol
Trikozol
Trimeks
Trivazol
UNII-140QMO216E
Vagilen
Vagimid
Vandazole
Vertisal
WLN: T5N CNJ A2Q B1 ENW
WLN: T5N CNJA2Q B1 ENW
WLN: T6NTJ DQ ANU1- ET5N CNJ A1 BNW
Wagitran
ZERO/004064
ZINC00113442
Zadstat
Zidoval
giniflavir
metronidazole
neo-Tric
5LaxativesPhase 2, Phase 3344
6Polyethylene glycol 3350Phase 2, Phase 390
7Gastrointestinal AgentsPhase 2, Phase 36401
8CatharticsPhase 2, Phase 3344
9Antiprotozoal AgentsPhase 2, Phase 31730
10Antibiotics, AntitubercularPhase 2, Phase 35971
11Antiparasitic AgentsPhase 2, Phase 31854
12Antibodies4477
13Immunoglobulins4477
14ColaNutraceutical1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Optimal Treatment for Recurrent Clostridium DifficileRecruitingNCT02667418Phase 4
2Intestinal Lavage for the Treatment of Severe C. Difficile InfectionsNot yet recruitingNCT02466698Phase 2, Phase 3
3Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated ColitisRecruitingNCT01959048
4Genetic Mosaicism in Hirschsprung's DiseaseRecruitingNCT01927809
5Host Immune Response to Clostridium Difficile InfectionRecruitingNCT02440438

Search NIH Clinical Center for Toxic Megacolon


Cochrane evidence based reviews: megacolon, toxic

Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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MalaCards organs/tissues related to Toxic Megacolon:

33
Colon, Bone, Endothelial, Lung, Testes, Bone marrow, Monocytes

Animal Models for Toxic Megacolon or affiliated genes

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MGI Mouse Phenotypes related to Toxic Megacolon:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0EDNRB, HTR7, IL18, IL1RN, LYZ, PFAS
2MP:00053817.9ALB, ATP12A, ATP4A, EDNRB, IL18, LYZ
3MP:00053766.5ALB, ATP12A, ATP4A, CRP, EDNRB, FLOT2
4MP:00053866.3EDNRB, FLOT2, HSPD1, HTR7, IL18, LYZ

Publications for Toxic Megacolon

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Articles related to Toxic Megacolon:

(show top 50)    (show all 234)
idTitleAuthorsYear
1
The Effects of Cigarette Smoke Condensate and Nicotine on Periodontal Tissue in a Periodontitis Model Mouse. (27203240)
2016
2
Transient Ischemic Attack After Foam Sclerotherapy in a Woman With a Patent Foramen Ovale. (27111786)
2016
3
Urticarial exanthem associated with Capnocytophaga canimorsus bacteremia after a dog bite. (27051842)
2016
4
Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-I^1, IFN-I^, and TNF-I+ genes in chronic phase chronic myeloid leukemia. (24819026)
2014
5
hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7. (24533984)
2014
6
Phaeochromocytoma masquerading as anxiety and depression. (23826457)
2013
7
Vestibular test findings in individuals with auditory neuropathy: review. (23521835)
2013
8
Cross validation with the mood disorder questionnaire (MDQ) of an instrument for the detection of hypomania in Brazil: The 32 item hypomania symptom check-list, first Revision (HCI-32-R1). (22284020)
2012
9
Alcohol and cannabis abuse/dependence symptoms and life satisfaction in young adulthood. (21733007)
2012
10
Intestinal paragonimiasis with colonic ulcer and hematochezia in an elderly Taiwanese woman. (23230334)
2012
11
Genetic risk markers for nasopharyngeal carcinoma in Portugal: tumor necrosis factor alphaa88 -308Ga88>A polymorphism. (20874489)
2011
12
The ligands of estrogen receptor I+ regulate cytochrome P4502C9 (CYP2C9) expression. (21493749)
2011
13
Hepatitis B virus X protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and PTEN]. (20813662)
2010
14
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (20622874)
2010
15
Cerebellar dysfunction in a calf with chronic coenurosis. (19377093)
2009
16
Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults. (19484842)
2009
17
The colposcopic feature ridge sign is associated with the presence of cervical intraepithelial neoplasia 2/3 and human papillomavirus 16 in young women. (19098601)
2009
18
Diagnosis of ectopic middle mediastinal parathyroid adenoma using endoscopic ultrasonography-guided fine-needle aspiration with real-time rapid parathyroid hormone assay. (19717031)
2009
19
Effect of ginseng-sanqi extract on the Ras associated signal proteins]. (19960977)
2009
20
The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. (18413347)
2008
21
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. (18949059)
2008
22
The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. (18408565)
2008
23
Public-private partnership works to stamp out sleeping sickness in Uganda. (17392023)
2007
24
Protein glutathionylation and oxidative stress. (17222592)
2007
25
Anencephaly in Singapore: vanquished or vanishing? (17245507)
2007
26
One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. (16868938)
2006
27
Rheumatoid factor is a marker of disease severity in Korean rheumatoid arthritis. (16127769)
2005
28
Biology of interleukin-10 and its regulatory roles in sepsis syndromes. (16340424)
2005
29
Coexpression of hepatocyte growth factor and its receptor c-Met correlates with high MIB-1 proliferative index in malignant fibrous histiocytoma. (15239348)
2004
30
Comparison of flow cytometry and enzyme cytochemistry for the detection of myeloperoxydase in acute myeloid leukaemia: interests of a new positivity threshold. (12846888)
2003
31
Relationship between the GH/IGF-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal boys. (11889181)
2002
32
Association of susceptibility locus for inflammatory bowel disease on chromosome 16 with both ulcerative colitis and Crohn's disease. (11318544)
2001
33
Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. (10806167)
2000
34
Disruption of microtubules in living cells by tyrphostin AG-1714. (10706777)
2000
35
p21(WAF-1/CIP-1), a downstream regulator of functional p53 loss, in transitional cell carcinoma of urothelium. (10895017)
2000
36
Erythrocyte-aggregating relapsing fever spirochete Borrelia crocidurae induces formation of microemboli. (10558950)
1999
37
The pathophysiology of polymyalgia rheumatica. (10606394)
1999
38
No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population. (10500259)
1999
39
A lymphokine-activated killer (LAK)-resistant cell line, and low expression of adhesion molecules LFA-3 and VCAM-1 on its cell surface. (9802061)
1998
40
Genetic susceptibility to the development of autoimmune disease. (9497784)
1997
41
Early increase of TNF alpha and IL-6 in tracheobronchial aspirate fluid indicator of subsequent chronic lung disease in preterm infants. (9462189)
1997
42
Niflumic acid differentially modulates two types of skeletal ryanodine-sensitive Ca(2+)-release channels. (9374644)
1997
43
A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. (8034649)
1994
44
Mosaic expression of hypohidrotic ectodermal dysplasia in an isolated affected female child. (7979445)
1994
45
Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. (8246443)
1993
46
Inhibition of thrombin generation by heparin and low molecular weight (LMW) heparins in the absence and presence of platelet factor 4 (PF4). (1329921)
1992
47
Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis. (1940977)
1991
48
Obstructed tilting disc mitral valve prosthesis associated with placenta praevia. (867335)
1977
49
Anatomic variations in underdeveloped right ventricle related to tricuspid atresia and stenosis. (957756)
1976
50
Thromboangiitis obliterans affecting the upper lip. Case report. (5276745)
1970

Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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Search GEO for disease gene expression data for Toxic Megacolon.

Pathways for genes affiliated with Toxic Megacolon

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Pathways related to Toxic Megacolon according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1HSPD1, IL1RN, RET, TAC1

GO Terms for genes affiliated with Toxic Megacolon

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Biological processes related to Toxic Megacolon according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1posterior midgut developmentGO:000749710.5EDNRB, RET
2cellular response to nerve growth factor stimulusGO:19900909.7NTS, TAC1
3regulation of pHGO:00068859.6ATP12A, EDNRB
4positive regulation of renal sodium excretionGO:00358159.6EDNRB, TAC1
5potassium ion importGO:00101079.3ATP12A, ATP4A

Sources for Toxic Megacolon

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet