MCID: TXC001
MIFTS: 29

Toxic Megacolon malady

Summaries for Toxic Megacolon

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63Wikipedia, 32MalaCards
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Wikipedia:63 Toxic megacolon (megacolon toxicum) is an acute form of colonic distension. It is characterized by a... more...

MalaCards: Toxic Megacolon, also known as megacolon, toxic, is related to megacolon and ulcerative colitis. An important gene associated with Toxic Megacolon is PFAS (phosphoribosylformylglycinamidine synthase). Affiliated tissues include colon, bone marrow and bone, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Toxic Megacolon

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

toxic megacolon 8 10
megacolon, toxic 60


External Ids:

Disease Ontology8 DOID:1770
SNOMED-CT56 28536002
MeSH34 D008532

Related Diseases for Toxic Megacolon

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17GeneCards, 18GeneDecks
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Diseases related to Toxic Megacolon via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1megacolon11.2
2ulcerative colitis10.9
3crohn's disease10.5
4inflammatory bowel disease10.3
5diarrhea10.3
6amyloidosis10.2
7compartment syndrome10.2
8disseminated intravascular coagulation10.2
9gastroenteritis10.2
10burns10.0
11colon lymphoma10.0
12amebiasis10.0
13kaposi's sarcoma10.0
14diverticulitis of colon10.0
15typhoid fever10.0
16shigellosis10.0
17invasive aspergillosis10.0
18aspergillosis10.0
19chorioretinitis10.0
20colonic disease10.0
21diverticulitis10.0
22dysentery10.0
23endophthalmitis10.0
24hepatitis10.0
25intestinal disease10.0
26intestinal perforation10.0
27ischemia10.0
28leukemia10.0
29sarcoma10.0

Graphical network of the top 20 diseases related to Toxic Megacolon:



Diseases related to toxic megacolon

Clinical Features for Toxic Megacolon

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Drugs & Therapeutics for Toxic Megacolon

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Toxic Megacolon

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Anatomical Context for Toxic Megacolon

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32MalaCards
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MalaCards organs/tissues related to Toxic Megacolon:

32
Colon, Bone marrow, Bone, Spinal cord, Heart, Smooth muscle, Myeloid

Animal Models for Toxic Megacolon or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Toxic Megacolon:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0TMC1, PFAS
2MP:00053918.7TMC1, PFAS

Publications for Toxic Megacolon

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50PubMed
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Articles related to Toxic Megacolon:

(show top 50)    (show all 224)
idTitleAuthorsYear
1
Unusual Complication of Toxic Megacolon in Typhoid Colitis. (23900751)
2013
2
Toxic megacolon secondary to Clostridium difficile colitis. Case report. (20423791)
2010
3
Management of acute colitis and toxic megacolon. (22131898)
2010
4
CMV infection in a pregnant woman complicated by toxic megacolon and mesenteric vein thrombosis. (19821211)
2009
5
A case of toxic megacolon in a patient with collagenous colitis. (19484403)
2009
6
Rotavirus gastroenteritis complicated with toxic megacolon. (19650837)
2009
7
Images in HIV/AIDS. HIV-associated toxic megacolon. (18828230)
2008
8
Advances in the diagnosis and management of toxic megacolon. (15776138)
2005
9
Early surgery for the treatment of toxic megacolon. (16172551)
2005
10
A patient who survived total colonic ulcerative colitis surinfected by cytomegalovirus complicated by toxic megacolon and disseminated intravascular coagulation. (16013652)
2005
11
BehAset's disease complicated by toxic megacolon. (14714626)
2003
12
Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome. (12734650)
2003
13
Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated. (12415367)
2002
14
Inflammatory pseudopolyposis in a patient with toxic megacolon due to pseudomembranous colitis. (11757676)
2001
15
Hyperbaric oxygen for toxic megacolon. (10023977)
1999
16
Toxic megacolon associated with Campylobacter jejuni colitis. (9934778)
1999
17
Toxic megacolon: diagnosis and treatment challenges. (10865533)
1999
18
A new treatment for toxic megacolon. (9737284)
1998
19
Gastrointestinal case of the day. Toxic megacolon with underlying ulcerative colitis. (8659382)
1996
20
Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon. (7557131)
1995
21
Toxic megacolon with late perforation in Campylobacter colitis--a cautionary tale. (8321804)
1993
22
Toxic megacolon. (8371619)
1993
23
Antibiotic-associated fulminant pseudomembranous colitis without toxic megacolon. (1449149)
1992
24
Fulminant colitis and toxic megacolon. (2493427)
1989
25
Toxic megacolon without diarrhea. (3189275)
1988
26
Toxic megacolon due to Campylobacter colitis. (3598331)
1987
27
Endoscopic colonic decompression of toxic megacolon, placement of colonic tube, and steroid colonclysis. (3605033)
1987
28
Toxic megacolon. An analysis of 70 cases. (3792159)
1986
29
Toxic megacolon in ulcerative colitis. Early diagnosis and management. (3091613)
1986
30
Surgery for acute ulcerative colitis and toxic megacolon during pregnancy. (4016538)
1985
31
Gallium-67 citrate scintigraphy in toxic megacolon. (6589103)
1984
32
Toxic megacolon: ultimate fate of patients after successful medical management. (6691535)
1984
33
Toxic megacolon after proctosigmoidoscopy in ulcerative colitis. (6879284)
1983
34
Filiform polyposis in Crohn's colitis mimicking toxic megacolon. (7297374)
1981
35
Toxic megacolon. (6996173)
1980
36
Toxic megacolon due to ischemic enterocolitis associated with retroperitoneal fibrosis. (7351296)
1980
37
Fatal amebiasis; with toxic megacolon and hepatic abscess. (6938815)
1980
38
Toxic megacolon in ulcerative colitis complicated by pneumomediastinum: report of two cases. (7429117)
1980
39
Toxic megacolon in ulcerative colitis and Crohn's colitis. (7389174)
1980
40
The place of steroids in the therapy of toxic megacolon. (213344)
1978
41
Toxic megacolon. (1246881)
1976
42
Editorial: Toxic megacolon. (1246883)
1976
43
Letter: Clindamycin-associated colitis with toxic megacolon. (1173848)
1975
44
Toxic megacolon. (4751075)
1973
45
Radiographic evaluation of toxic megacolon in acute ulcerative colitis. (4484006)
1972
46
Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. (5570601)
1971
47
Toxic megacolon. (4395949)
1971
48
Toxic megacolon--experience with 5 cases in the S. Transvaal. (5502162)
1970
49
Toxic megacolon. (4184121)
1969
50
TOXIC MEGACOLON COMPLICATING CHRONIC ULCERATIVE COLITIS. (14315434)
1965

Genetic Variations for Toxic Megacolon

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Expression for genes affiliated with Toxic Megacolon

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Megacolon

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Pathways for genes affiliated with Toxic Megacolon

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Compounds for genes affiliated with Toxic Megacolon

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GO Terms for genes affiliated with Toxic Megacolon

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Products for genes affiliated with Toxic Megacolon

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Megacolon

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet