TSS
MCID: TXC005
MIFTS: 62

Toxic Shock Syndrome (TSS) malady

Infectious diseases category
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Summaries for Toxic Shock Syndrome

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Disease Ontology:8 A commensal bacterial infectious disease that results in infection, has material basis in streptococcus pyogenes or has material basis in staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. the infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary: Toxic Shock Syndrome, also known as shock, toxic, is related to arthritis and peritonitis, and has symptoms including An important gene associated with Toxic Shock Syndrome is IL1B (interleukin 1, beta), and among its related pathways are African trypanosomiasis and IL-10 Pathway. The compounds tenidap and n,n-dimethylsphingosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and monocytes, and related mouse phenotypes are respiratory system and skeleton.

Wikipedia:65 Toxic shock syndrome (TSS) is a potentially fatal illness caused by a bacterial toxin. Different... more...

Aliases & Classifications for Toxic Shock Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Toxic Shock Syndrome, Aliases & Descriptions:

Name: Toxic Shock Syndrome 8 10 44 62
Shock, Toxic 62
 
Toxic Shock 8
Tss 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:14115
ICD9CM27 040.82
NCIt39 C35498
SNOMED-CT57 18504008, 240450004
MeSH34 D012772
ICD1025 A48.3

Related Diseases for Toxic Shock Syndrome

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Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.3IL1B, TNF
2peritonitis31.0IL1B, TNF
3pneumonia30.6IL1B, TNF, EDNRA
4atopic dermatitis30.5LTA, TNF, LBR
5measles30.4LBR, CIITA
6influenza30.4LBR, CIITA, LTA
7lymphopenia30.4CIITA, LBR
8psoriasis30.2LTA, IL1B, CIITA, TNF
9myeloma30.2LTA, IL1B, CIITA
10sepsis30.2C1S, TNF, CIITA, IL1B, LTA
11encephalitis29.9CIITA, IL1B
12septic shock29.8C1S, TNF, CIITA, IL1B, LTA
13rheumatoid arthritis29.8C1S, LBR, TNF, CIITA, IL1B, LTA
14ischemia29.8EDNRA, C1S, CIITA
15lung cancer29.5EDNRA, C1S, LBR, CIITA
16systemic lupus erythematosus29.5C1S, LBR, TNF, CIITA, LTA
17streptococcal toxic-shock syndrome11.2
18staphylococcal toxic shock syndrome11.1
19burns10.8
20fasciitis10.7
21necrotizing fasciitis10.7
22vaginitis10.6
23pyomyositis10.5
24degenerative disc disease10.5IL1B
25periodontitis10.5IL1B
26scarlet fever10.5
27bacteremia10.5
28psoriatic arthritis10.4TNF
29skin disease10.4IL1B
30ocular cicatricial pemphigoid10.4CIITA
31neuritis10.4CIITA
32tracheitis10.4
33breast reconstruction10.3
34pharyngitis10.3
35endocarditis10.3
36eosinophilia10.3
37myositis10.3
38blau syndrome10.3IL1B, TNF
39aids dementia complex10.3IL1B, TNF
40familial mediterranean fever10.3IL1B, TNF
41chorioamnionitis10.3IL1B, TNF
42interstitial lung disease10.3IL1B, TNF
43shigellosis10.3LTA, IL1B
44cerebral malaria10.3IL1B, TNF
45respiratory failure10.3IL1B, TNF
46acute graft versus host disease10.3TNF, LTA
47acute cholangitis10.3
48kawasaki disease10.3
49sudden infant death syndrome10.3
50artery disease10.3

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to toxic shock syndrome

Symptoms for Toxic Shock Syndrome

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Drugs & Therapeutics for Toxic Shock Syndrome

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Drug clinical trials:

Search ClinicalTrials for Toxic Shock Syndrome

Search NIH Clinical Center for Toxic Shock Syndrome

Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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MalaCards organs/tissues related to Toxic Shock Syndrome:

32
T cells, Breast, Monocytes, Skin, B cells, Bone, Colon, Lung, Testes, Neutrophil

Animal Models for Toxic Shock Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Toxic Shock Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0EDNRA, LBR, TNF, LTA
2MP:00053907.9EDNRA, LBR, TNF, IL1B, LTA
3MP:00036317.9LTA, IL1B, TNF, LBR, EDNRA
4MP:00053797.8EDNRA, LBR, TNF, CIITA, LTA
5MP:00053977.5LTA, IL1B, CIITA, TNF, LBR, EDNRA
6MP:00053877.5EDNRA, LBR, TNF, CIITA, IL1B, LTA
7MP:00053767.3EDNRA, LBR, TNF, CIITA, IL1B, LTA

Publications for Toxic Shock Syndrome

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Articles related to Toxic Shock Syndrome:

(show top 50)    (show all 606)
idTitleAuthorsYear
1
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. (25260866)
2014
2
Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses. (24531180)
2014
3
The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia. (25024509)
2014
4
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
5
A case of Staphylococcus toxic shock syndrome presenting with multiple pneumatocoeles in the chest. (23798091)
2013
6
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
7
Cytotoxicity of lymphocytes activated by superantigen toxic-shock-syndrome toxin-1 against colorectal cancer LoVo cells. (23340976)
2013
8
Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. (21304813)
2011
9
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
10
Toxic shock syndrome - evolution of an emerging disease. (21120726)
2011
11
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
12
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. (20368967)
2010
13
Toxic shock syndrome after prosthetic breast reconstruction with AlloDerm. (19568065)
2009
14
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. (19465927)
2009
15
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
16
Clostridium sordellii toxic shock syndrome. (19926032)
2009
17
A fatal case of streptococcal toxic shock syndrome. (18453517)
2008
18
Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. (18532937)
2008
19
An Australian case of Streptococcus suis toxic shock syndrome associated with occupational exposure to animal carcasses. (18459929)
2008
20
Chitosan malate inhibits growth and exotoxin production of toxic shock syndrome-inducing Staphylococcus aureus strains and group A streptococci. (17576832)
2007
21
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
22
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
23
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
24
Streptococcal toxic shock syndrome manifesting as peritonitis in a child. (12353345)
2002
25
Group A streptococcal toxic shock syndrome developing in the third trimester of pregnancy. (12648315)
2002
26
Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. (11865410)
2002
27
Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1. (11372026)
2001
28
Postpartum Clostridium sordellii infection associated with fatal toxic shock syndrome. (11130102)
2000
29
Toxic shock syndrome after suction lipectomy. (10883636)
2000
30
Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals. (10816521)
2000
31
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
32
Toxic shock syndrome associated with newly diagnosed type I diabetes. (10849234)
2000
33
Toxic shock syndrome in adult burns. (10563695)
1999
34
Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells. (9551963)
1998
35
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
36
Induction of selective anergy by toxic shock syndrome toxin-1 in CD8+ T cells. (9415025)
1997
37
Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth. (9257741)
1997
38
Anaphylactoid reaction to ciprofloxacin versus toxic shock syndrome. (8997481)
1997
39
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections. (9361388)
1997
40
Carboxy-terminal residues of major histocompatibility complex class II-associated peptides control the presentation of the bacterial superantigen toxic shock syndrome toxin-1 to T cells. (9079821)
1997
41
Prokaryotic production of the human T cell receptor Vbeta2 chain and binding to toxic-shock syndrome toxin-1. (8654955)
1996
42
Toxic shock syndrome: role of the environment, the host and the microorganism. (9069106)
1996
43
T-cell activation and proliferation in a case of recurrent menstrual toxic shock syndrome. (8837379)
1996
44
Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1. (8976639)
1996
45
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
46
Effect of Merocel vaginal sponge on growth of Staphylococcus aureus and production of toxic shock syndrome-associated toxins. (8673303)
1996
47
Identification from a phage display library of peptides that bind to toxic shock syndrome toxin-1 and that inhibit its binding to major histocompatibility complex (MHC) class II molecules. (8756700)
1996
48
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
49
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
50
Toxic shock syndrome associated with pyomyositis caused by a strain of Staphylococcus aureus that does not produce toxic-shock-syndrome toxin-1. (3611834)
1987

Variations for Toxic Shock Syndrome

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Expression for genes affiliated with Toxic Shock Syndrome

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Expression patterns in normal tissues for genes affiliated with Toxic Shock Syndrome

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Pathways for genes affiliated with Toxic Shock Syndrome

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Pathways related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNF, IL1B
29.7TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity37
9.7IL1B, TNF
49.7IL1B, TNF
59.7IL1B, TNF
69.7IL1B, TNF
7
Show member pathways
thioredoxin pathway37
9.7IL1B, TNF
89.7IL1B, TNF
99.7IL1B, TNF
109.7IL1B, TNF
119.7IL1B, TNF
129.7IL1B, TNF
13
Show member pathways
9.6LTA, TNF
149.6CIITA, IL1B
15
Show member pathways
IL27-mediated signaling events37
9.2TNF, IL1B, LTA
169.2LTA, IL1B, TNF
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2TNF, IL1B, LTA
18
Show member pathways
9.2TNF, IL1B, LTA
199.2LTA, IL1B, TNF
209.2LTA, IL1B, TNF
21
Show member pathways
9.2LTA, IL1B, TNF
22
Show member pathways
9.2TNF, IL1B, LTA
23
Show member pathways
9.2LTA, IL1B, TNF
249.2TNF, CIITA, IL1B
25
Show member pathways
9.2IL1B, CIITA, TNF
269.1IL1B, TNF, C1S
27
Show member pathways
8.7LTA, IL1B, CIITA, TNF
28
Show member pathways
8.7LTA, IL1B, CIITA, TNF
29
Show member pathways
8.4EDNRA, TNF, IL1B, LTA

Compounds for genes affiliated with Toxic Shock Syndrome

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Compounds related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1tenidap44 2811.0IL1B, TNF
2n,n-dimethylsphingosine44 6111.0TNF, IL1B
3anakinra44 1111.0TNF, IL1B
4cicaprost44 2811.0IL1B, TNF
5vesnarinone449.9IL1B, TNF
6taurine chloramine449.9TNF, IL1B
7mip 1alpha449.8IL1B, TNF
8actinomycin449.7IL1B, TNF
9gold sodium thiomalate449.7IL1B, TNF
10lipoteichoic acid449.6LTA, IL1B, TNF
11il 10449.6LTA, TNF, IL1B
12ivig449.6TNF, IL1B, LTA
13polyinosinic-polycytidylic acid449.6IL1B, CIITA, TNF
14tgf beta1449.6TNF, IL1B, LTA
15peptidoglycan44 2810.5IL1B, CIITA, TNF
16herbimycin a44 6110.5IL1B, TNF, LTA
17rantes449.5IL1B, LBR, CIITA
18okt3449.5LBR, LTA, TNF
19fmlp449.4IL1B, TNF, LTA
20ionomycin449.3TNF, LBR, LTA
21l-nmma449.3EDNRA, TNF, IL1B
22infliximab44 50 1111.2IL1B, TNF, LBR, LTA
23pentoxifylline44 1110.1LTA, IL1B, TNF, LBR
24neopterin449.1IL1B, LTA, TNF, LBR
25mannose449.1LTA, CIITA, C1S
26prednisolone44 28 1111.1LTA, TNF, EDNRA
27actinomycin d449.1IL1B, LTA, CIITA, TNF
28etanercept44 50 1111.1TNF, LTA, C1S, IL1B
29prostaglandin449.0EDNRA, TNF, IL1B
30calcitriol44 61 24 1111.9IL1B, LTA, TNF
31indomethacin44 28 61 1111.8TNF, EDNRA, LTA, IL1B
32histamine44 28 2410.7LBR, EDNRA, TNF, IL1B
33prostacyclin448.7IL1B, EDNRA, TNF, C1S
34cycloheximide448.6TNF, LTA, IL1B, CIITA, LBR
35h2o2448.6LBR, LTA, EDNRA, TNF
36enterotoxin448.6CIITA, LTA, LBR, EDNRA
37cyclic amp44 249.5CIITA, EDNRA, LBR, LTA
38cholesterol44 28 24 1111.4LBR, LTA, CIITA, EDNRA
39steroid448.4LBR, CIITA, LTA, EDNRA
40toxin-1448.3EDNRA, IL1B, CIITA, LTA, TNF
41endotoxin448.3IL1B, CIITA, TNF, LTA, EDNRA
42arachidonic acid44 28 24 1111.3IL1B, TNF, LBR, EDNRA, LTA
43vegf448.3EDNRA, TNF, IL1B, LTA
44pge2448.3LTA, IL1B, TNF, EDNRA, CIITA
45thymidine44 249.2TNF, EDNRA, IL1B, CIITA, LBR
46cyclosporin a44 28 6110.2LTA, CIITA, TNF, LBR, EDNRA
47lipid448.1LTA, EDNRA, LBR, TNF, CIITA
48dexamethasone44 50 28 1110.8IL1B, TNF, LTA, EDNRA, LBR, CIITA
49serine447.5C1S, TNF, LBR, EDNRA, LTA, CIITA
50nitric oxide44 24 119.2C1S, LBR, TNF, LTA, EDNRA, IL1B

GO Terms for genes affiliated with Toxic Shock Syndrome

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Biological processes related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of fever generationGO:03162210.1IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.0IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
8negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:04234610.0IL1B, TNF
10positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.0LTA, TNF
11lipopolysaccharide-mediated signaling pathwayGO:03166310.0TNF, IL1B
12positive regulation of mitosisGO:04584010.0IL1B, TNF
13positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0LTA, TNF
14protein kinase B signalingGO:04349110.0IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:04542910.0IL1B, TNF
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1B, TNF
17negative regulation of growth of symbiont in hostGO:0441309.9LTA, TNF
18cellular response to organic cyclic compoundGO:0714079.9IL1B, TNF
19positive regulation of interleukin-6 productionGO:0327559.9TNF, IL1B
20positive regulation of JNK cascadeGO:0463309.8IL1B, TNF
21defense response to Gram-positive bacteriumGO:0508309.8LTA, TNF
22humoral immune responseGO:0069599.7LTA, TNF
23positive regulation of interferon-gamma productionGO:0327299.6LTA, IL1B, TNF
24MAPK cascadeGO:0001659.6IL1B, TNF
25inflammatory responseGO:0069549.4TNF, CIITA, IL1B
26regulation of insulin secretionGO:0507969.4IL1B, TNF
27cellular response to mechanical stimulusGO:0712609.3IL1B, EDNRA
28apoptotic processGO:0069159.2LTA, IL1B, TNF
29positive regulation of protein phosphorylationGO:0019349.2EDNRA, TNF, IL1B
30positive regulation of transcription, DNA-templatedGO:0458939.2TNF, CIITA, IL1B
31response to hypoxiaGO:0016669.1LTA, TNF, EDNRA

Molecular functions related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.6LTA, TNF
2cytokine activityGO:0051258.9LTA, IL1B, TNF

Products for genes affiliated with Toxic Shock Syndrome

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Sources for Toxic Shock Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet