MCID: TXC005
MIFTS: 51

Toxic Shock Syndrome malady

Infectious diseases category

Aliases & Classifications for Toxic Shock Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 38NCIt, 33MeSH, 25ICD10
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Toxic Shock Syndrome, Aliases & Descriptions:

Name: Toxic Shock Syndrome 9 11 43 60
Toxic Shock 9
 
Tss 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:14115
ICD9CM27 040.82
NCIt38 C35498
SNOMED-CT55 240450004, 18504008
MeSH33 D012772
ICD1025 A48.3

Summaries for Toxic Shock Syndrome

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Disease Ontology:9 A commensal bacterial infectious disease that results in infection, has material basis in streptococcus pyogenes or has material basis in staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. the infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary: Toxic Shock Syndrome, also known as toxic shock, is related to arthritis and peritonitis, and has symptoms including fever, rash and hypotension. An important gene associated with Toxic Shock Syndrome is IL1B (interleukin 1, beta), and among its related pathways are African trypanosomiasis and IL-10 Pathway. The compounds tenidap and n,n-dimethylsphingosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and monocytes, and related mouse phenotypes are respiratory system and skeleton.

Wikipedia:63 Toxic shock syndrome (TSS) is a potentially fatal illness caused by a bacterial toxin. Different... more...

Related Diseases for Toxic Shock Syndrome

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Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.3IL1B, TNF
2peritonitis31.0TNF, IL1B
3pneumonia30.6EDNRA, TNF, IL1B
4atopic dermatitis30.5LBR, TNF, LTA
5malaria30.5TNF, IL1B
6measles30.4CIITA, LBR
7influenza30.4LTA, LBR, CIITA
8lymphopenia30.4CIITA, LBR
9psoriasis30.2TNF, IL1B, LTA, CIITA
10myeloma30.2CIITA, IL1B, LTA
11encephalitis29.9IL1B, CIITA
12ischemia29.8EDNRA, CIITA, C1S
13rheumatoid arthritis29.7LBR, LTA, IL1B, CIITA, TNF, C1S
14lung cancer29.5C1S, EDNRA, CIITA, LBR
15systemic lupus erythematosus29.5CIITA, TNF, C1S, LBR, LTA
16streptococcal toxic-shock syndrome11.2
17staphylococcal toxic shock syndrome11.1
18burns10.8
19fasciitis10.8
20necrotizing fasciitis10.7
21vaginitis10.6
22pyomyositis10.5
23intervertebral disc disease10.5IL1B
24periodontitis10.5IL1B
25bacteremia10.5
26scarlet fever10.5
27skin disease10.4IL1B
28psoriatic arthritis10.4TNF
29ocular cicatricial pemphigoid10.4CIITA
30neuritis10.4CIITA
31tracheitis10.4
32breast reconstruction10.3
33pharyngitis10.3
34endocarditis10.3
35eosinophilia10.3
36myositis10.3
37blau syndrome10.3IL1B, TNF
38aids dementia complex10.3TNF, IL1B
39familial mediterranean fever, ar10.3IL1B, TNF
40chorioamnionitis10.3TNF, IL1B
41interstitial lung disease10.3TNF, IL1B
42shigellosis10.3LTA, IL1B
43respiratory failure10.3TNF, IL1B
44sudden infant death syndrome10.3
45kawasaki disease10.3
46coronary artery disease10.3
47splenic infarction10.3
48acute cholangitis10.3
49artery disease10.3
50cervicitis10.3

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to toxic shock syndrome

Symptoms for Toxic Shock Syndrome

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Symptoms:

 9 (show all 9)
  • fever
  • rash
  • hypotension
  • multiorgan failure
  • desquamation
  • vomiting
  • diarrhea
  • headache
  • nonfocal neurologic abnormalities

Drugs & Therapeutics for Toxic Shock Syndrome

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Drug clinical trials:

Search ClinicalTrials for Toxic Shock Syndrome

Search NIH Clinical Center for Toxic Shock Syndrome

Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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MalaCards organs/tissues related to Toxic Shock Syndrome:

31
T cells, Breast, Monocytes, Skin, B cells, Bone, Colon, Lung, Testes, Neutrophil

Animal Models for Toxic Shock Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Toxic Shock Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0EDNRA, LBR, TNF, LTA
2MP:00053907.9EDNRA, LBR, TNF, IL1B, LTA
3MP:00036317.9LTA, IL1B, TNF, LBR, EDNRA
4MP:00053797.8EDNRA, LBR, TNF, CIITA, LTA
5MP:00053977.5LTA, IL1B, CIITA, TNF, LBR, EDNRA
6MP:00053877.5EDNRA, LBR, TNF, CIITA, IL1B, LTA
7MP:00053767.3EDNRA, LBR, TNF, CIITA, IL1B, LTA

Publications for Toxic Shock Syndrome

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Articles related to Toxic Shock Syndrome:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. (25260866)
2014
2
Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses. (24531180)
2014
3
The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia. (25024509)
2014
4
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
5
A case of Staphylococcus toxic shock syndrome presenting with multiple pneumatocoeles in the chest. (23798091)
2013
6
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
7
Cytotoxicity of lymphocytes activated by superantigen toxic-shock-syndrome toxin-1 against colorectal cancer LoVo cells. (23340976)
2013
8
Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. (21304813)
2011
9
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
10
Toxic shock syndrome - evolution of an emerging disease. (21120726)
2011
11
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
12
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. (20368967)
2010
13
Toxic shock syndrome after prosthetic breast reconstruction with AlloDerm. (19568065)
2009
14
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. (19465927)
2009
15
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
16
Clostridium sordellii toxic shock syndrome. (19926032)
2009
17
A fatal case of streptococcal toxic shock syndrome. (18453517)
2008
18
Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. (18532937)
2008
19
An Australian case of Streptococcus suis toxic shock syndrome associated with occupational exposure to animal carcasses. (18459929)
2008
20
Chitosan malate inhibits growth and exotoxin production of toxic shock syndrome-inducing Staphylococcus aureus strains and group A streptococci. (17576832)
2007
21
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
22
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
23
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
24
Streptococcal toxic shock syndrome manifesting as peritonitis in a child. (12353345)
2002
25
Group A streptococcal toxic shock syndrome developing in the third trimester of pregnancy. (12648315)
2002
26
Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. (11865410)
2002
27
Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1. (11372026)
2001
28
Postpartum Clostridium sordellii infection associated with fatal toxic shock syndrome. (11130102)
2000
29
Toxic shock syndrome after suction lipectomy. (10883636)
2000
30
Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals. (10816521)
2000
31
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
32
Toxic shock syndrome associated with newly diagnosed type I diabetes. (10849234)
2000
33
Toxic shock syndrome in adult burns. (10563695)
1999
34
Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells. (9551963)
1998
35
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
36
Induction of selective anergy by toxic shock syndrome toxin-1 in CD8+ T cells. (9415025)
1997
37
Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth. (9257741)
1997
38
Anaphylactoid reaction to ciprofloxacin versus toxic shock syndrome. (8997481)
1997
39
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections. (9361388)
1997
40
Carboxy-terminal residues of major histocompatibility complex class II-associated peptides control the presentation of the bacterial superantigen toxic shock syndrome toxin-1 to T cells. (9079821)
1997
41
Prokaryotic production of the human T cell receptor Vbeta2 chain and binding to toxic-shock syndrome toxin-1. (8654955)
1996
42
Toxic shock syndrome: role of the environment, the host and the microorganism. (9069106)
1996
43
T-cell activation and proliferation in a case of recurrent menstrual toxic shock syndrome. (8837379)
1996
44
Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1. (8976639)
1996
45
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
46
Effect of Merocel vaginal sponge on growth of Staphylococcus aureus and production of toxic shock syndrome-associated toxins. (8673303)
1996
47
Identification from a phage display library of peptides that bind to toxic shock syndrome toxin-1 and that inhibit its binding to major histocompatibility complex (MHC) class II molecules. (8756700)
1996
48
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
49
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
50
Toxic shock syndrome associated with pyomyositis caused by a strain of Staphylococcus aureus that does not produce toxic-shock-syndrome toxin-1. (3611834)
1987

Variations for Toxic Shock Syndrome

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Expression for genes affiliated with Toxic Shock Syndrome

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Search GEO for disease gene expression data for Toxic Shock Syndrome.

Pathways for genes affiliated with Toxic Shock Syndrome

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Pathways related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNF, IL1B
29.7TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity36
9.7IL1B, TNF
49.7IL1B, TNF
59.7IL1B, TNF
69.7IL1B, TNF
7
Show member pathways
thioredoxin pathway36
9.7IL1B, TNF
89.7IL1B, TNF
99.7IL1B, TNF
109.7IL1B, TNF
119.7IL1B, TNF
129.7IL1B, TNF
13
Show member pathways
9.6LTA, TNF
149.6CIITA, IL1B
15
Show member pathways
IL27-mediated signaling events36
9.2TNF, IL1B, LTA
169.2LTA, IL1B, TNF
17
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.2TNF, IL1B, LTA
18
Show member pathways
9.2TNF, IL1B, LTA
199.2LTA, IL1B, TNF
209.2LTA, IL1B, TNF
21
Show member pathways
9.2LTA, IL1B, TNF
22
Show member pathways
9.2TNF, IL1B, LTA
23
Show member pathways
9.2LTA, IL1B, TNF
249.2TNF, CIITA, IL1B
25
Show member pathways
9.2IL1B, CIITA, TNF
269.1IL1B, TNF, C1S
27
Show member pathways
8.7LTA, IL1B, CIITA, TNF
28
Show member pathways
8.7LTA, IL1B, CIITA, TNF
29
Show member pathways
8.4EDNRA, TNF, IL1B, LTA

Compounds for genes affiliated with Toxic Shock Syndrome

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Compounds related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1tenidap43 2811.0IL1B, TNF
2n,n-dimethylsphingosine43 5911.0TNF, IL1B
3anakinra43 1211.0TNF, IL1B
4cicaprost43 2811.0IL1B, TNF
5vesnarinone439.9IL1B, TNF
6taurine chloramine439.9TNF, IL1B
7mip 1alpha439.8IL1B, TNF
8actinomycin439.7IL1B, TNF
9gold sodium thiomalate439.7IL1B, TNF
10lipoteichoic acid439.6LTA, IL1B, TNF
11il 10439.6LTA, TNF, IL1B
12ivig439.6TNF, IL1B, LTA
13polyinosinic-polycytidylic acid439.6IL1B, CIITA, TNF
14tgf beta1439.6TNF, IL1B, LTA
15peptidoglycan43 2810.5IL1B, CIITA, TNF
16herbimycin a43 5910.5IL1B, TNF, LTA
17rantes439.5IL1B, LBR, CIITA
18okt3439.5LBR, LTA, TNF
19fmlp439.4IL1B, TNF, LTA
20ionomycin439.3TNF, LBR, LTA
21l-nmma439.3EDNRA, TNF, IL1B
22infliximab43 49 1211.2IL1B, TNF, LBR, LTA
23pentoxifylline43 1210.1LTA, IL1B, TNF, LBR
24neopterin439.1IL1B, LTA, TNF, LBR
25mannose439.1LTA, CIITA, C1S
26prednisolone43 28 1211.1LTA, TNF, EDNRA
27actinomycin d439.1IL1B, LTA, CIITA, TNF
28etanercept43 49 1211.1TNF, LTA, C1S, IL1B
29prostaglandin439.0EDNRA, TNF, IL1B
30calcitriol43 59 24 1211.9IL1B, LTA, TNF
31indomethacin43 28 59 1211.8TNF, EDNRA, LTA, IL1B
32histamine43 28 2410.7LBR, EDNRA, TNF, IL1B
33prostacyclin438.7IL1B, EDNRA, TNF, C1S
34cycloheximide438.6TNF, LTA, IL1B, CIITA, LBR
35h2o2438.6LBR, LTA, EDNRA, TNF
36enterotoxin438.6CIITA, LTA, LBR, EDNRA
37cyclic amp43 249.5CIITA, EDNRA, LBR, LTA
38cholesterol43 28 24 1211.4LBR, LTA, CIITA, EDNRA
39steroid438.4LBR, CIITA, LTA, EDNRA
40toxin-1438.3EDNRA, IL1B, CIITA, LTA, TNF
41endotoxin438.3IL1B, CIITA, TNF, LTA, EDNRA
42arachidonic acid43 28 24 1211.3IL1B, TNF, LBR, EDNRA, LTA
43vegf438.3EDNRA, TNF, IL1B, LTA
44pge2438.3LTA, IL1B, TNF, EDNRA, CIITA
45thymidine43 249.2TNF, EDNRA, IL1B, CIITA, LBR
46cyclosporin a43 28 5910.2LTA, CIITA, TNF, LBR, EDNRA
47lipid438.1LTA, EDNRA, LBR, TNF, CIITA
48dexamethasone43 49 28 1210.8IL1B, TNF, LTA, EDNRA, LBR, CIITA
49serine437.5C1S, TNF, LBR, EDNRA, LTA, CIITA
50nitric oxide43 24 129.2C1S, LBR, TNF, LTA, EDNRA, IL1B

GO Terms for genes affiliated with Toxic Shock Syndrome

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Biological processes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.1TNF, IL1B
2sequestering of triglycerideGO:003073010.1TNF, IL1B
3positive regulation of fever generationGO:003162210.1IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:004508010.0IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:005104410.0TNF, IL1B
8negative regulation of lipid catabolic processGO:005099510.0IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:004234610.0IL1B, TNF
10positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.0LTA, TNF
11lipopolysaccharide-mediated signaling pathwayGO:003166310.0TNF, IL1B
12positive regulation of mitosisGO:004584010.0IL1B, TNF
13positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.0LTA, TNF
14protein kinase B signalingGO:004349110.0IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:004542910.0IL1B, TNF
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.9IL1B, TNF
17negative regulation of growth of symbiont in hostGO:00441309.9LTA, TNF
18cellular response to organic cyclic compoundGO:00714079.9IL1B, TNF
19positive regulation of interleukin-6 productionGO:00327559.9TNF, IL1B
20positive regulation of JNK cascadeGO:00463309.8IL1B, TNF
21defense response to Gram-positive bacteriumGO:00508309.8LTA, TNF
22humoral immune responseGO:00069599.7LTA, TNF
23positive regulation of interferon-gamma productionGO:00327299.6LTA, IL1B, TNF
24MAPK cascadeGO:00001659.6IL1B, TNF
25inflammatory responseGO:00069549.4TNF, CIITA, IL1B
26regulation of insulin secretionGO:00507969.4IL1B, TNF
27cellular response to mechanical stimulusGO:00712609.3IL1B, EDNRA
28apoptotic processGO:00069159.2LTA, IL1B, TNF
29positive regulation of protein phosphorylationGO:00019349.2EDNRA, TNF, IL1B
30positive regulation of transcription, DNA-templatedGO:00458939.2TNF, CIITA, IL1B
31response to hypoxiaGO:00016669.1LTA, TNF, EDNRA

Molecular functions related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.6LTA, TNF
2cytokine activityGO:00051258.9LTA, IL1B, TNF

Products for genes affiliated with Toxic Shock Syndrome

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Sources for Toxic Shock Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet