TSS
MCID: TXC005
MIFTS: 61

Toxic Shock Syndrome (TSS) malady

Infectious diseases category
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Summaries for Toxic Shock Syndrome

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that results in infection, has material basis in streptococcus pyogenes or has material basis in staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. the infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards: Toxic Shock Syndrome, also known as shock, toxic, is related to arthritis and peritonitis, and has symptoms including nonfocal neurologic abnormalities, headache and diarrhea. An important gene associated with Toxic Shock Syndrome is IL1B (interleukin 1, beta), and among its related pathways are African trypanosomiasis and IL-10 Pathway. The compounds tenidap and n,n-dimethylsphingosine have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and breast, and related mouse phenotypes are respiratory system and skeleton.

Wikipedia:65 Toxic shock syndrome (TSS) is a potentially fatal illness caused by a bacterial toxin. Different... more...

Aliases & Classifications for Toxic Shock Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

toxic shock syndrome 8 10 45
shock, toxic 62
toxic shock 8
tss 8


External Ids:

Disease Ontology8 DOID:14115
MeSH35 D012772
NCIt40 C35498
SNOMED-CT58 240450004, 18504008
ICD9CM27 040.82
ICD1025 A48.3

Related Diseases for Toxic Shock Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to toxic shock syndrome

Symptoms for Toxic Shock Syndrome

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8Disease Ontology
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Symptoms:

8 (show all 9)
  • nonfocal neurologic abnormalities
  • headache
  • diarrhea
  • vomiting
  • desquamation
  • multiorgan failure
  • hypotension
  • rash
  • fever

Drugs & Therapeutics for Toxic Shock Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Toxic Shock Syndrome

Search NIH Clinical Center for Toxic Shock Syndrome

Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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33MalaCards
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MalaCards organs/tissues related to Toxic Shock Syndrome:

33
T cells, Monocytes, Breast, Skin, B cells, Testes, Lung, Colon, Bone

Animal Models for Toxic Shock Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Toxic Shock Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0EDNRA, LBR, TNF, LTA
2MP:00053907.9EDNRA, LBR, TNF, IL1B, LTA
3MP:00036317.9LTA, IL1B, TNF, LBR, EDNRA
4MP:00053797.8EDNRA, LBR, TNF, CIITA, LTA
5MP:00053977.5LTA, IL1B, CIITA, TNF, LBR, EDNRA
6MP:00053877.5EDNRA, LBR, TNF, CIITA, IL1B, LTA
7MP:00053767.3EDNRA, LBR, TNF, CIITA, IL1B, LTA

Publications for Toxic Shock Syndrome

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Sources:
52PubMed
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Articles related to Toxic Shock Syndrome:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
2
A case of Staphylococcus toxic shock syndrome presenting with multiple pneumatocoeles in the chest. (23798091)
2013
3
Streptococcal toxic shock syndrome following total thyroidectomy. (24112488)
2013
4
Cytotoxicity of lymphocytes activated by superantigen toxic-shock-syndrome toxin-1 against colorectal cancer LoVo cells. (23340976)
2013
5
Toxic shock syndrome related to Streptococcus equi subsp zooepidemicus. (24014562)
2013
6
Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. (21304813)
2011
7
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. (21860665)
2011
8
Toxic shock syndrome - evolution of an emerging disease. (21120726)
2011
9
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
10
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates. (20368967)
2010
11
Toxic shock syndrome after prosthetic breast reconstruction with AlloDerm. (19568065)
2009
12
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. (19465927)
2009
13
Necrotizing fascitis and streptococcal toxic shock syndrome complicating herpes zoster: a vaccine talking point? (21246167)
2009
14
Clostridium sordellii toxic shock syndrome. (19926032)
2009
15
Intravenous immunoglobulin in children with streptococcal toxic shock syndrome. (19788359)
2009
16
A fatal case of streptococcal toxic shock syndrome. (18453517)
2008
17
Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. (18532937)
2008
18
An Australian case of Streptococcus suis toxic shock syndrome associated with occupational exposure to animal carcasses. (18459929)
2008
19
Chitosan malate inhibits growth and exotoxin production of toxic shock syndrome-inducing Staphylococcus aureus strains and group A streptococci. (17576832)
2007
20
Staphylococcal toxic shock syndrome: still a problem. (16116687)
2005
21
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
22
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
23
Managing toxic shock syndrome. (12640786)
2003
24
Streptococcal toxic shock syndrome manifesting as peritonitis in a child. (12353345)
2002
25
Group A streptococcal toxic shock syndrome developing in the third trimester of pregnancy. (12648315)
2002
26
Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. (11865410)
2002
27
Inhibition of staphylococcal enterotoxin A-induced superantigenic and lethal activities by a monoclonal antibody to toxic shock syndrome toxin-1. (11372026)
2001
28
Role of T cells and gamma interferon during induction of hypersensitivity to lipopolysaccharide by toxic shock syndrome toxin 1 in mice. (11179286)
2001
29
Postpartum Clostridium sordellii infection associated with fatal toxic shock syndrome. (11130102)
2000
30
Toxic shock syndrome after suction lipectomy. (10883636)
2000
31
Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals. (10816521)
2000
32
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
33
Toxic shock syndrome associated with newly diagnosed type I diabetes. (10849234)
2000
34
Toxic shock syndrome in adult burns. (10563695)
1999
35
Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells. (9551963)
1998
36
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome. (9868656)
1998
37
Induction of selective anergy by toxic shock syndrome toxin-1 in CD8+ T cells. (9415025)
1997
38
Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth. (9257741)
1997
39
Anaphylactoid reaction to ciprofloxacin versus toxic shock syndrome. (8997481)
1997
40
Carboxy-terminal residues of major histocompatibility complex class II-associated peptides control the presentation of the bacterial superantigen toxic shock syndrome toxin-1 to T cells. (9079821)
1997
41
Regulation of toxic shock syndrome toxin-1 gene in Staphylococcus aureus. (9085261)
1997
42
Prokaryotic production of the human T cell receptor Vbeta2 chain and binding to toxic-shock syndrome toxin-1. (8654955)
1996
43
Toxic shock syndrome: role of the environment, the host and the microorganism. (9069106)
1996
44
T-cell activation and proliferation in a case of recurrent menstrual toxic shock syndrome. (8837379)
1996
45
Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1. (8976639)
1996
46
Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. (8643591)
1996
47
Identification from a phage display library of peptides that bind to toxic shock syndrome toxin-1 and that inhibit its binding to major histocompatibility complex (MHC) class II molecules. (8756700)
1996
48
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. (8903167)
1995
49
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
50
Toxic shock syndrome associated with pyomyositis caused by a strain of Staphylococcus aureus that does not produce toxic-shock-syndrome toxin-1. (3611834)
1987

Variations for Toxic Shock Syndrome

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Expression for genes affiliated with Toxic Shock Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Shock Syndrome

Search GEO for disease gene expression data for Toxic Shock Syndrome.

Pathways for genes affiliated with Toxic Shock Syndrome

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 55Reactome
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Pathways related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TNF, IL1B
29.7TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity38
9.7IL1B, TNF
49.7IL1B, TNF
59.7IL1B, TNF
69.7IL1B, TNF
7
Show member pathways
thioredoxin pathway38
9.7IL1B, TNF
89.7IL1B, TNF
99.7IL1B, TNF
109.7IL1B, TNF
119.7IL1B, TNF
129.7IL1B, TNF
13
Show member pathways
9.6LTA, TNF
149.6CIITA, IL1B
15
Show member pathways
IL27-mediated signaling events38
9.2TNF, IL1B, LTA
169.2LTA, IL1B, TNF
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2TNF, IL1B, LTA
18
Show member pathways
9.2TNF, IL1B, LTA
199.2LTA, IL1B, TNF
209.2LTA, IL1B, TNF
21
Show member pathways
9.2LTA, IL1B, TNF
22
Show member pathways
9.2TNF, IL1B, LTA
23
Show member pathways
9.2LTA, IL1B, TNF
249.2TNF, CIITA, IL1B
25
Show member pathways
9.2IL1B, CIITA, TNF
269.1IL1B, TNF, C1S
27
Show member pathways
8.7LTA, IL1B, CIITA, TNF
28
Show member pathways
8.7LTA, IL1B, CIITA, TNF
29
Show member pathways
8.4EDNRA, TNF, IL1B, LTA

Compounds for genes affiliated with Toxic Shock Syndrome

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1tenidap45 2911.0IL1B, TNF
2n,n-dimethylsphingosine45 6111.0TNF, IL1B
3anakinra45 1111.0TNF, IL1B
4cicaprost45 2911.0IL1B, TNF
5vesnarinone459.9IL1B, TNF
6taurine chloramine459.9TNF, IL1B
7mip 1alpha459.8IL1B, TNF
8actinomycin459.7IL1B, TNF
9gold sodium thiomalate459.7IL1B, TNF
10lipoteichoic acid459.6LTA, IL1B, TNF
11il 10459.6LTA, TNF, IL1B
12ivig459.6TNF, IL1B, LTA
13polyinosinic-polycytidylic acid459.6IL1B, CIITA, TNF
14tgf beta1459.6TNF, IL1B, LTA
15peptidoglycan45 2910.5IL1B, CIITA, TNF
16herbimycin a45 6110.5IL1B, TNF, LTA
17rantes459.5IL1B, LBR, CIITA
18okt3459.5LBR, LTA, TNF
19fmlp459.4IL1B, TNF, LTA
20ionomycin459.3TNF, LBR, LTA
21l-nmma459.3EDNRA, TNF, IL1B
22infliximab45 51 1111.2IL1B, TNF, LBR, LTA
23pentoxifylline45 1110.1LTA, IL1B, TNF, LBR
24neopterin459.1IL1B, LTA, TNF, LBR
25mannose459.1LTA, CIITA, C1S
26prednisolone45 29 1111.1LTA, TNF, EDNRA
27actinomycin d459.1IL1B, LTA, CIITA, TNF
28etanercept45 51 1111.1TNF, LTA, C1S, IL1B
29prostaglandin459.0EDNRA, TNF, IL1B
30calcitriol45 61 24 1111.9IL1B, LTA, TNF
31indomethacin45 29 61 1111.8TNF, EDNRA, LTA, IL1B
32histamine45 29 2410.7LBR, EDNRA, TNF, IL1B
33prostacyclin458.7IL1B, EDNRA, TNF, C1S
34cycloheximide458.6TNF, LTA, IL1B, CIITA, LBR
35h2o2458.6LBR, LTA, EDNRA, TNF
36enterotoxin458.6CIITA, LTA, LBR, EDNRA
37cyclic amp45 249.5CIITA, EDNRA, LBR, LTA
38cholesterol45 29 24 1111.4LBR, LTA, CIITA, EDNRA
39steroid458.4LBR, CIITA, LTA, EDNRA
40toxin-1458.3EDNRA, IL1B, CIITA, LTA, TNF
41endotoxin458.3IL1B, CIITA, TNF, LTA, EDNRA
42arachidonic acid45 29 24 1111.3IL1B, TNF, LBR, EDNRA, LTA
43vegf458.3EDNRA, TNF, IL1B, LTA
44pge2458.3LTA, IL1B, TNF, EDNRA, CIITA
45thymidine45 249.2TNF, EDNRA, IL1B, CIITA, LBR
46cyclosporin a45 29 6110.2LTA, CIITA, TNF, LBR, EDNRA
47lipid458.1LTA, EDNRA, LBR, TNF, CIITA
48dexamethasone45 51 29 1110.8IL1B, TNF, LTA, EDNRA, LBR, CIITA
49serine457.5C1S, TNF, LBR, EDNRA, LTA, CIITA
50nitric oxide45 24 119.2C1S, LBR, TNF, LTA, EDNRA, IL1B

GO Terms for genes affiliated with Toxic Shock Syndrome

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16Gene Ontology
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Biological processes related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.1TNF, IL1B
2sequestering of triglycerideGO:03073010.1TNF, IL1B
3positive regulation of fever generationGO:03162210.1IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.0IL1B, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:05104410.0TNF, IL1B
8negative regulation of lipid catabolic processGO:05099510.0IL1B, TNF
9positive regulation of NF-kappaB import into nucleusGO:04234610.0IL1B, TNF
10positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.0LTA, TNF
11lipopolysaccharide-mediated signaling pathwayGO:03166310.0TNF, IL1B
12positive regulation of mitosisGO:04584010.0IL1B, TNF
13positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0LTA, TNF
14protein kinase B signalingGO:04349110.0IL1B, TNF
15positive regulation of nitric oxide biosynthetic processGO:04542910.0IL1B, TNF
16negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1B, TNF
17negative regulation of growth of symbiont in hostGO:0441309.9LTA, TNF
18cellular response to organic cyclic compoundGO:0714079.9IL1B, TNF
19positive regulation of interleukin-6 productionGO:0327559.9TNF, IL1B
20positive regulation of JNK cascadeGO:0463309.8IL1B, TNF
21defense response to Gram-positive bacteriumGO:0508309.8LTA, TNF
22humoral immune responseGO:0069599.7LTA, TNF
23positive regulation of interferon-gamma productionGO:0327299.6LTA, IL1B, TNF
24MAPK cascadeGO:0001659.6IL1B, TNF
25inflammatory responseGO:0069549.4TNF, CIITA, IL1B
26regulation of insulin secretionGO:0507969.4IL1B, TNF
27cellular response to mechanical stimulusGO:0712609.3IL1B, EDNRA
28apoptotic processGO:0069159.2LTA, IL1B, TNF
29positive regulation of protein phosphorylationGO:0019349.2EDNRA, TNF, IL1B
30positive regulation of transcription, DNA-templatedGO:0458939.2TNF, CIITA, IL1B
31response to hypoxiaGO:0016669.1LTA, TNF, EDNRA

Molecular functions related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.6LTA, TNF
2cytokine activityGO:0051258.9LTA, IL1B, TNF

Products for genes affiliated with Toxic Shock Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Shock Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet