TSS
MCID: TXC005
MIFTS: 63

Toxic Shock Syndrome (TSS) malady

Infectious diseases category

Summaries for Toxic Shock Syndrome

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that results in infection, has material basis in streptococcus pyogenes or has material basis in staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. the infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards: Toxic Shock Syndrome, also known as shock, toxic, is related to arthritis and peritonitis, and has symptoms including nonfocal neurologic abnormalities, desquamation and multiorgan failure. An important gene associated with Toxic Shock Syndrome is IL1B (interleukin 1, beta), and among its related pathways are Leishmaniasis and Senescence and Autophagy. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and breast, and related mouse phenotypes are skeleton and hematopoietic system.

Wikipedia:63 Toxic shock syndrome (TSS) is a potentially fatal illness caused by a bacterial toxin. Different... more...

Aliases & Classifications for Toxic Shock Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

toxic shock syndrome 8 10 44
shock, toxic 60
toxic shock 8
tss 8


External Ids:

Disease Ontology8 DOID:14115
ICD9CM27 040.82
MeSH34 D012772
SNOMED-CT56 18504008, 240450004
NCIt39 C35498
ICD1025 A48.3

Related Diseases for Toxic Shock Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8IL1B, IL8, TNF
2peritonitis30.6LACTB, IL1B, CD69, TNF
3rheumatoid arthritis30.6HMGB1, IL1B, IL8, IL1RN, CD69, LTA
4kawasaki disease30.5CIITA
5pneumonia30.5LACTB, HMGB1, IL1B, IL8, KNG1, EDNRA
6down syndrome30.4CCL4
7myositis30.4IL1RN, CIITA
8eosinophilia30.4IL8, CD69, IGHE, IFNG
9mastitis30.3IL1B, IL8
10dermatitis30.3IGHE, IFNG
11pancreatitis30.3IL1B, KNG1, C1S
12meningitis30.3LACTB, IL1B, IL8, CCL4
13influenza30.3LACTB, CD69, LTA, KNG1, CIITA, LBR
14atopic dermatitis30.3IL8, CD69, LTA, IGHE, LBR, TNF
15psoriasis30.3IL1B, IL8, CD69, LTA, CIITA, TNF
16lupus erythematosus30.1C1S
17multiple myeloma30.1CCL3
18wegener's granulomatosis30.1CIITA
19hepatitis30.1LTA, EDNRA
20hepatitis b30.1CIITA, IFNG
21aspergillosis30.1IFNG, CCL3
22measles30.1CIITA, LBR, CCL4
23acute pancreatitis30.1IL8, IL1RN, C1S
24gastritis30.1IL1B, IL8, IL1RN, CCL3
25colorectal cancer30.1HMGB1, EDNRA, LBR
26ischemia30.1CD69, KNG1, CIITA, EDNRA, C1S
27lymphopenia30.1IL1RN, CIITA, LBR, IFNG
28breast cancer30.1HMGB1, CD69, CIITA, CCL3, CCL4
29myeloma30.1IL1B, LTA, MYOM2, IGHE, CIITA, CCL3
30lung cancer30.1HMGB1, KNG1, CIITA, EDNRA, LBR, C1S
31systemic lupus erythematosus30.1IL1RN, CD69, LTA, CIITA, LBR, TNF
32malaria29.9HMGB1, KNG1, TNF, IFNG
33encephalitis29.9HMGB1, IL1B, CIITA, CCL3, CCL4
34adenoma29.9EDNRA
35burns10.7
36fasciitis10.7
37necrotizing fasciitis10.7
38adult syndrome10.6
39vaginitis10.5
40staphylococcal toxic shock syndrome10.5
41exfoliation syndrome10.5
42pyomyositis10.4
43scarlet fever10.4
44tracheitis10.4
45streptococcal toxic-shock syndrome10.4
46breast reconstruction10.3
47pharyngitis10.3
48coronary artery disease10.2
49sudden infant death syndrome10.2
50splenic infarction10.2

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to toxic shock syndrome

Clinical Features for Toxic Shock Syndrome

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • nonfocal neurologic abnormalities
  • desquamation
  • multiorgan failure
  • rash
  • vomiting
  • diarrhea
  • headache
  • fever
  • hypotension

Drugs & Therapeutics for Toxic Shock Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Toxic Shock Syndrome

Drug clinical trials:

Search ClinicalTrials for Toxic Shock Syndrome

Search NIH Clinical Center for Toxic Shock Syndrome

Search CenterWatch for Toxic Shock Syndrome

Genetic Tests for Toxic Shock Syndrome

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Anatomical Context for Toxic Shock Syndrome

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Sources:
32MalaCards
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MalaCards organs/tissues related to Toxic Shock Syndrome:

32
T cells, Monocytes, Breast, Skin, B cells, Colon, Lung, Bone, Testes

Animal Models for Toxic Shock Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Toxic Shock Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.3EDNRA, LTA, IL1B
2MP:00053979.6CIITA, EDNRA, LBR, TNF, CCL3, IFNG
3MP:00053879.6KLRD1, CCL3, IFNG, TNF, LBR, EDNRA
4MP:00053769.4LBR, KNG1, CIITA, EDNRA, IFNG, TNF

Publications for Toxic Shock Syndrome

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Sources:
50PubMed
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Articles related to Toxic Shock Syndrome:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. (23370754)
2013
2
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. (22431984)
2012
3
Staphylococcal enterotoxin B toxic shock syndrome induced by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). (23124156)
2012
4
Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. (21304813)
2011
5
T-cell response to superantigen restimulation during menstrual toxic shock syndrome. (21492259)
2011
6
Gram-positive bacterial superantigen outside-in signaling causes toxic shock syndrome. (21535475)
2011
7
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
8
Phlegmonous gastritis and group A streptococcal toxic shock syndrome in a patient following functional endoscopic sinus surgery. (20575666)
2010
9
Severe group A streptococcal toxic shock syndrome presenting as primary peritonitis: a case report and brief review of the literature. (19914115)
2010
10
Procalcitonin as a biomarker for toxic shock syndrome. (20574626)
2010
11
Puerperal streptococcal toxic shock syndrome treated with recombinant human activated protein C and intravenous immunoglobulin. (19195874)
2009
12
Toxic shock syndrome due to group A streptococcal pharyngitis and bacteremia in adults. (19812863)
2009
13
One in five mortality in non-menstrual toxic shock syndrome versus no mortality in menstrual cases in a balanced French series of 55 cases. (17932694)
2008
14
Puerperal widespread pyomyositis after group A streptococcal toxic shock syndrome. (18669156)
2008
15
Abortion and clostridial toxic shock syndrome. (18310387)
2008
16
Nonmenstrual toxic shock syndrome due to methicillin-resistant Staphylococcus aureus. (18827138)
2008
17
New football boots and toxic shock syndrome. (16763251)
2006
18
Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. (16584289)
2006
19
Fatal streptococcal toxic shock syndrome in a patient with rheumatoid arthritis treated with etanercept. (15870144)
2005
20
Staphylococcal toxic shock syndrome: still a problem. (15963025)
2005
21
Streptococcal toxic shock syndrome presenting with spontaneous hypoglycemia in a chronic hemodialysis patient: pathophysiological mechanisms. (12793713)
2003
22
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. (12884156)
2003
23
Toxic shock syndrome following cessation of prophylactic antibiotics in a child with a 2% scald. (11900944)
2002
24
Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. (10816471)
2000
25
Development of streptococcal pyrogenic exotoxin C vaccine toxoids that are protective in the rabbit model of toxic shock syndrome. (10925320)
2000
26
Human bite on penile shaft from oral sex as a portal of entry for streptococcal toxic shock syndrome. (11344784)
2000
27
The effect of site-specific monoclonal antibodies directed to toxic shock syndrome toxin-1 in experimental Staphylococcus aureus arthritis. (10540189)
1999
28
Analysis of mec regulator genes in clinical methicillin-resistant Staphylococcus aureus isolates according to the production of coagulase, types of enterotoxin, and toxic shock syndrome toxin-1. (10434474)
1999
29
Toxic Shock Syndrome in a neonate? (9686667)
1998
30
Insulin regulates IL-1alpha, Ifn-y and IL-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S. (17657628)
1998
31
Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity. (9585531)
1998
32
Separation of function between the domains of toxic shock syndrome toxin-1. (9551921)
1998
33
Toxic shock syndrome following minor surgery in pregnancy resulting in premature labour and subsequent neonatal death. (15512048)
1998
34
Another toxic shock syndrome. Streptococcal infection is even more dangerous than the staphylococcal form. (9861255)
1998
35
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections. (9361388)
1997
36
Carboxy-terminal residues of major histocompatibility complex class II-associated peptides control the presentation of the bacterial superantigen toxic shock syndrome toxin-1 to T cells. (9079821)
1997
37
Toxic shock syndrome in AIDS. (9248898)
1997
38
Novel superantigens from streptococcal toxic shock syndrome Streptococcus pyogenes isolates. (9331707)
1997
39
Group A streptococcal meningitis and toxic shock syndrome caused by a protein M type 3 strain producing exotoxin C. (9177970)
1997
40
Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1. (8976639)
1996
41
The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. (8921429)
1996
42
Acute pancreatitis associated with streptococcal toxic shock syndrome. (8729223)
1996
43
Further evidence of streptococcal toxic shock syndrome in pets. (8960165)
1996
44
Inhalational mercury poisoning masquerading as toxic shock syndrome. (8085634)
1994
45
Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1. (8253961)
1993
46
Pediatric streptococcal toxic shock syndrome. (1513730)
1992
47
Role of the adhesion molecule lymphocyte function associated antigen 1 in toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human monocytes. (1399006)
1992
48
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
49
Causes of staphylococcal toxic shock syndrome. (2380842)
1990
50
An acquired antithrombin III deficiency in the course of toxic shock syndrome after elective orthopaedic surgery. (6866173)
1983

Genetic Variations for Toxic Shock Syndrome

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Expression for genes affiliated with Toxic Shock Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxic Shock Syndrome

Search GEO for disease gene expression data for Toxic Shock Syndrome.

Pathways for genes affiliated with Toxic Shock Syndrome

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome, 52R&D Systems
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Pathways related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4CIITA
210.4IL8
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.4IFNG
410.4IL1B, TNF
5
Hide members
10.3LTA, CCL4
6
Hide members
10.3CCL3, EDNRA
710.3IL1B, TNF, IL8
8
Hide members
10.3IL1B, IL8, TNF
910.3IFNG, TNF, IL1B
1010.3IFNG, TNF, IL1B
1110.3TNF, IL1B, IFNG
12
Hide members
10.3LTA, IFNG, TNF
1310.3IL1B, CIITA, IFNG
1410.3CCL3, IL1B, TNF
1510.3IFNG, TNF, IL8
16
Hide members
10.3IFNG, IL8, TNF
1710.3TNF, KNG1, HMGB1
18
Hide members
10.3CCL4, CCL3, LTA
19
Hide members
10.2LTA, IL1B, IFNG, TNF
2010.2IL1B, IL8, TNF, C1S
2110.2CIITA, TNF, IFNG, IL1B
2210.2TNF, IL1RN, IL8, IL1B
2310.2CCL3, IL8, CCL4
24
Hide members
10.2IL1B, TNF, IFNG, IL8
2510.2TNF, IL8, IL1B, IFNG
26
Hide members
10.2IFNG, IL1RN, IL1B, CIITA
27
Hide members
10.2CCL3, CCL4, IL1B, IFNG
2810.2IL8, IFNG, KLRC1, KLRD1
29
Hide members
10.2CCL4, TNF, IFNG, CCL3
3010.2LTA, TNF, IL8, IL1B, IFNG
31
Hide members
10.2C1S, KLRC1, KLRD1, IGHE
32
Immune response Bacterial infections in normal airways
Hide members
10.2IL1RN, IL1B, IFNG, IL8, TNF
3310.2IL1B, IL8, LTA, TNF, CCL4
34
Hide members
10.1IL8, IL1B, IFNG, TNF, CIITA, LTA
3510.1CCL4, IFNG, IL1B, IL8, CCL3
36
Hide members
10.1IGHE, IFNG, TNF, KLRC1, KLRD1
37
Hide members
10.1TNF, CCL3, IL8, IL1B, LTA, CCL4
38
Hide members
10.1IL1B, IL8, TNF, IFNG, CCL3, CCL4
39
Hide members
10.0KLRC1, CIITA, TNF, IFNG, KLRD1, LTA
40
Hide members
9.9IL1B, IL1RN, C1S, IGHE, KLRC1, IFNG

Compounds for genes affiliated with Toxic Shock Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9LTA
2indomethacin44 59 28 1113.8EDNRA, KNG1
3endotoxin4410.7CIITA, EDNRA, HMGB1
4pentoxifylline44 1111.7IL1RN, LTA, LBR
5hydrocortisone44 2 59 1113.7IL8, IGHE
6gm-csf44 2811.6IFNG, TNF
7prednisolone44 28 1112.6CCL4, LTA, IGHE, EDNRA
8dexamethasone44 49 28 1113.6IGHE, LTA, LBR, EDNRA, CIITA
9fmlp4410.5CCL3, CD69, IL1RN
10gold sodium thiomalate4410.5IL8, IL1B, IFNG, TNF, IL1RN
11mip 1alpha4410.5TNF, CCL4, CCL3, IL8, IL1B
12lipoteichoic acid4410.5CCL3, IL1RN, TNF, LTA, IL8, IL1B
13etanercept44 49 1112.5LTA, C1S, IL8, IFNG, IL1RN, IL1B
14polyinosinic-polycytidylic acid4410.5CIITA, IFNG, TNF, IL8, IL1B, CCL3
15triptolide4410.5IFNG, CCL4, IL1B, CCL3, IL8, TNF
16polymyxin b4410.4IFNG, TNF, IL1RN, IL8, IL1B
17infliximab44 49 1112.4LBR, IL1RN, IFNG, TNF, IGHE, LTA
18poly(i-c)4410.4IFNG, CCL3, CD69, TNF, IL8, IL1B
19peptidoglycan44 2811.4CIITA, IL1B, IL8, IL1RN, CCL4, TNF
20ivig4410.4IL1B, LTA, TNF, IL1RN, CCL4, IGHE
21allergens4410.4CCL4, IFNG, CIITA, IGHE, CD69
22groalpha4410.4IL1B, IL8, CCL4, CCL3, TNF
23ccl344 2811.4IL1B, TNF, CCL4, IFNG, IL8, CCL3
24neopterin4410.4IFNG, IL8, IL1B, CCL3, LBR, LTA
25il 104410.4CCL3, IFNG, TNF, LTA, IL1RN, IL8
26rantes4410.4IFNG, CCL3, CCL4, TNF, LBR, LTA
27budesonide44 49 1112.4TNF, IGHE, IL8, IL1B, IFNG
28tarc4410.4IL8, IGHE, IFNG, CCL4, CCL3, TNF
29l-nmma4410.4CCL3, IFNG, IL1B, TNF, EDNRA, KNG1
30taurine chloramine4410.3IL1B, TNF, IFNG, IL8
31fluticasone propionate44 49 59 1113.3IL1B, IL8, IGHE, TNF, IFNG
32ionomycin4410.3IFNG, CD69, TNF, LBR, KNG1, CCL3
33simvastatin44 49 59 28 11 2415.3IFNG, CCL3, TNF, CIITA, IL1RN, IL8
34leukotriene b444 59 2412.3CCL3, TNF, KNG1, IL1RN, IL8, IL1B
35cyclosporin a44 28 5912.3CCL3, IFNG, LBR, EDNRA, CIITA, IGHE
36oxygen44 2411.2IL8, HMGB1, CIITA, CCL3, EDNRA, TNF
37sb 20358044 5911.2CCL4, IL1RN, HMGB1, IL1B, IL8, TNF
38actinomycin d4410.2IL8, CD69, IL1B, IGHE, KNG1, CIITA
39heparin44 28 11 2413.2C1S, CCL3, HMGB1, IL8, IL1RN, CD69
40toxin-14410.2IL8, IL1B, IL1RN, LTA, KLRC1, CCL4
41histamine44 28 2412.2IL8, IL1B, IL1RN, CCL4, CCL3, IFNG
42herbimycin a44 5911.1IL8, LTA, TNF, IFNG, IL1B, CD69
43prostaglandin4410.1TNF, IL1B, IL1RN, KNG1, CCL4, EDNRA
44vegf4410.1IL1RN, CCL4, CCL3, TNF, EDNRA, IGHE
45serine4410.1CCL3, TNF, CIITA, KNG1, CCL4, IL1RN
46thymidine44 2411.0IFNG, CD69, CIITA, EDNRA, LBR, TNF
47mannose4410.0C1S, CIITA, LTA, CD69, IL1RN, CCL4
48retinoic acid44 2410.9TNF, IL1B, IL1RN, HMGB1, LTA, CCL4
49nitric oxide44 11 2411.9EDNRA, LBR, TNF, IFNG, CCL3, CCL4
50pd 98,059449.7TNF, CCL3, CD69, IL8, IL1B, HMGB1

GO Terms for genes affiliated with Toxic Shock Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.2CD69, TNF, IFNG, KLRD1
2extracellular spaceGO:0056159.7IL8, IL1B, IL1RN, LTA, KNG1, TNF
3extracellular regionGO:0055769.5HMGB1, C1S, IL1B, IL8, IGHE, KNG1

Biological processes related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.7TNF, LTA
2positive regulation of vitamin D biosynthetic processGO:06055710.7IFNG, TNF
3chronic inflammatory response to antigenic stimulusGO:00243910.7IL1RN, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.7IL1B, IFNG, TNF
5positive regulation of chemokine biosynthetic processGO:04508010.7IFNG, TNF, IL1B
6sequestering of triglycerideGO:03073010.7TNF, IL1B
7positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IL1B, TNF, IFNG
8negative regulation of growth of symbiont in hostGO:04413010.7LTA, TNF, IFNG
9positive regulation of heterotypic cell-cell adhesionGO:03411610.7TNF, IL1B
10lipopolysaccharide-mediated signaling pathwayGO:03166310.7IL1B, CCL3, TNF
11positive regulation of fever generationGO:03162210.7IL1B, TNF
12positive regulation of interferon-gamma productionGO:03272910.6TNF, LTA, IL1B
13positive regulation of nitric oxide biosynthetic processGO:04542910.6TNF, IFNG, IL1B
14cellular response to organic cyclic compoundGO:07140710.6CCL3, IL1B, TNF
15protein kinase B signaling cascadeGO:04349110.6CCL3, TNF, IL1B
16positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.6TNF, LTA
17humoral immune responseGO:00695910.6TNF, IFNG, LTA
18neutrophil chemotaxisGO:03059310.6CCL3, IFNG, IL8, IL1B
19positive regulation of natural killer cell chemotaxisGO:200050310.6CCL4, CCL3
20calcium-mediated signalingGO:01972210.6CCL3, TNF, IL8
21cell activationGO:00177510.6TNF, CCL3
22positive regulation of interleukin-6 biosynthetic processGO:04541010.6IFNG, IL1B
23positive regulation of MHC class II biosynthetic processGO:04534810.5CIITA, IFNG
24MAPK cascadeGO:00016510.5IL1B, TNF, CCL3
25inflammatory responseGO:00695410.5CCL4, CCL3, TNF, KNG1, IL1B, IL8
26immune responseGO:00695510.4IL1RN, IGHE, CIITA, CCL4, IL8, IL1B
27regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.4TNF, IL1B
28regulation of insulin secretionGO:05079610.4IFNG, TNF, IL1B
29cell-cell signalingGO:00726710.3IL1B, LTA, CCL3, CCL4
30negative regulation by host of viral transcriptionGO:04392210.3CCL3, CCL4
31positive regulation of apoptotic processGO:04306510.2LTA, HMGB1, KNG1, TNF
32positive regulation of protein phosphorylationGO:00193410.2IL1B, EDNRA, TNF
33response to drugGO:0424939.9TNF, IFNG, LTA, IL1RN

Molecular functions related to Toxic Shock Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR1 chemokine receptor bindingGO:03172610.3CCL3, CCL4
2CCR5 chemokine receptor bindingGO:03173010.2CCL3, CCL4
3cytokine activityGO:00512510.1HMGB1, IL1B, LTA, TNF, IFNG, CCL4
4chemokine activityGO:0080099.9CCL3, CCL4, IL8

Products for genes affiliated with Toxic Shock Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxic Shock Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet