Toxic Shock Syndrome malady

Disease Ontology: A commensal bacterial infectious disease that results in infection, has material basis in streptococcus pyogenes or has material basis in staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. the infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.⁶

MalaCards: Toxic Shock Syndrome, also known as toxic shock syndrome (disorder), is related to staphylococcal toxic shock syndrome and rheumatoid arthritis, and has symptoms including fever, rash and hypotension. An important gene associated with Toxic Shock Syndrome is CIITA (class II, major histocompatibility complex, transactivator), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Graft-versus-host disease. The compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include monocytes, t cells and b cells, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Toxic shock syndrome (TSS) is a potentially fatal illness caused by a bacterial toxin. Different...⁴⁴ more...

Aliases & Descriptions:

toxic shock syndrome 6 8 32 toxic shock syndrome (disorder) 6 shock, toxic 43

toxic shock 6 tss 6

Diseases related to toxic shock syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 711)

id	Related Disease	Score	Top Affiliating Genes
1	staphylococcal toxic shock syndrome	34.5	CIITA, IL1B, IGHE, HMGB1, TNF
2	rheumatoid arthritis	29.6	CIITA, IL10, IL1B, IL1RN, IL2, TNF
3	sepsis	29.1	IL10, TNF, LTA
4	ehrlichiosis	28.6	CD40LG, IL10, IFNG, TNF
5	arthritis	28.4	IL1B, IL6, IL8, TNF
6	atopic dermatitis	27.0	LBR, CD69, FCER2, IL10, IL2, IL4
7	purpura	23.3	SERPINC1, LACTB, CD40LG, IL10, IL1B, IL1RN
8	peritonitis	23.3	PIK3C2A, SERPINC1, LBR, LACTB, CD69, CD40LG
9	dermatitis	22.1	PIK3C2A, SETBP1, CIITA, LBR, CD69, CD4
10	pneumonia	21.2	PIK3C2A, SERPINC1, LACTB, CD69, CD4, CD40LG
11	vulvar vestibulitis syndrome	13.8	IL1B, IL1RN, TNF
12	stachybotrys chartarum	13.8	IL1B, CCL4, CCL3
13	cardiac sarcoidosis	13.8	IL1B, IFNG, TNF, LTA
14	farmer's lung	13.8	IL2, IGHE, TNF
15	chronic progressive multiple sclerosis	13.8	IL2, IFNG, TNF
16	periodic fever	13.8	IL1B, IL1RN, IFNG, TNF
17	central nervous system leukemia	13.8	IL1B, TNF
18	autoimmune myocarditis	13.7	CIITA, IL2, IFNG, TNF
19	gastric cancer risk after h. pylori infection	13.7	IL1B, IL1RN
20	paratyphoid fever	13.7	IL1B, IFNG, TNF, SUMF2
21	oral tuberculosis	13.7	IL2, TNF
22	campylobacteriosis	13.7	IL1B, IFNG, SUMF2
23	tuberculous uveitis	13.7	IFNG, TNF
24	cytomegalovirus retinitis	13.7	IL2, IFNG, TNF
25	retinal vasculitis	13.7	SAG, CCL4, TNF
26	epiglottitis	13.6	RDH11, LACTB, C1S
27	crescentic glomerulonephritis	13.6	IL1RN, CCL4, CCL3, TNF
28	tropical spastic paraparesis	13.6	IL2, CCL3, IFNG
29	pulmonary sarcoidosis	13.6	LBR, IL2, CCL3, IFNG, TNF, LTA
30	chronic conjunctivitis	13.6	FCER2, IGHE
31	typhoid fever	13.6	LACTB, IL1B, IFNG, TNF, SUMF2, LTA
32	beryllium disease, chronic	13.6	IFNG, HLA-DPB1
33	schnitzler syndrome	13.6	CD40LG, IL1RN, TNF
34	ritter's disease	13.6	GML, SUMF2, EDNRA, EDNRB
35	orchitis	13.6	CD4, IFNG, TNF
36	coccidiosis	13.5	CD4, IL2, IFNG
37	opportunistic bacterial infectious disease	13.5	LBR, LACTB, CD4, IFNG, TNF
38	lymphocytic choriomeningitis	13.5	CD4, IL2, IFNG, TNF
39	necrotizing fasciitis	13.5	PIK3C2A, IGHE, SPEG
40	meningococcemia	13.5	SERPINC1, IL1B, IL1RN
41	septic arthritis	13.5	LACTB, IL1B, IFNG, TNF, PLAU
42	sympathetic ophthalmia	13.4	IL10, TNF, LTA
43	intermediate uveitis	13.4	CD69, IL10, IFNG, TNF
44	short bowel syndrome	13.4	IL1B, IGHE, ALB, TNF
45	blau syndrome	13.4	IL10, IL1B, TNF
46	strongyloidiasis	13.4	IGHE, IFNG, ALB
47	obstructive lung disease	13.4	LACTB, IGHE, ALB, TNF, LTA
48	adult t-cell leukemia	13.4	CIITA, CD4, IL2, KLRC1, KLRD1
49	extrapulmonary tuberculosis	13.4	IL10, IL1B, IL1RN, IFNG
50	punctate inner choroidopathy	13.4	IL10, TNF

Symptoms: fever, rash, hypotension, multiorgan failure, desquamation, vomiting, diarrhea, headache, nonfocal neurologic abnormalities.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to toxic shock syndrome:

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MGI Mouse Phenotypes related to toxic shock syndrome:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	SPEG
2	hematopoietic system phenotype	MP:0005397	10.3	IGHE, FCER2, CD69, SELK
3	no phenotypic analysis	MP:0003012	9.5	SELK, LBR, CD69, CD4, KLRD1, EDNRB
4	endocrine/exocrine gland phenotype	MP:0005379	9.5	EPHA4, EDNRA, LTA, IFNG, IL2, CD40LG
5	skeleton phenotype	MP:0005390	9.1	EDNRB, PLAU, IL6, CD69
6	digestive/alimentary phenotype	MP:0005381	8.6	EDNRB, EDNRA, PLAU, IFNG, CCL3, FCER2
7	immune system phenotype	MP:0005387	8.5	SELK, EDNRB, EDNRA, TNF, IFNG, CCL3
8	homeostasis/metabolism phenotype	MP:0005376	7.3	ALB, HMGB1, PLAU, LTA, EDNRA, EDNRB
9	vision/eye phenotype	MP:0005391	7.3	EDNRB, LTA, PLAU, TNF, HMGB1, IFNG
10	reproductive system phenotype	MP:0005389	7.1	EPHA4, TNF, HSPD1, IFNG, IL6, IL4
11	mortality/aging	MP:0010768	7.1	IFNG, HSPD1, SPEG, PLAU, LTA, EDNRB
12	cardiovascular system phenotype	MP:0005385	6.6	SPEG, PLAU, LTA, EDNRA, EDNRB, EPHX2
13	cellular phenotype	MP:0005384	5.8	IL6, CCL3, IFNG, HMGB1, TNF, PLAU

Articles related to toxic shock syndrome:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	Novel toxic shock syndrome toxin-1 amino acids required for biological activity. (19012411)	Brosnahan A.J.... Schlievert P.M.	2008	IL8
2	Staphylococcus aureus of phage type 187 isolated from people occurred to be a genes carrier of eneterotoxin C and toxic shock syndrome toxin-1 (TSST-1). (17997135)	Piechowicz L.... Galinski J.	2008	GPR162
3	Case of severe streptococcus pyogenes pneumonia with streptococcus toxic shock syndrome (18592996)	Izumiyama N.... Kikuchi Y.	2008	PIK3C2A
4	Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. (19009026)	Kalyan S.... Chow A.W.	2008	HMGB1
5	Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. (11865410)	Kum W.W.... Chow A.W.	2002	CD40LG
6	Neutralizing activity of human immunoglobulin prepar ation against toxic shock syndrome toxin-1 (11974889)	Nakae T.... Hashimoto M.	2002	IFNG
7	Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells. (11705931)	Kum W.W.... Chow A.W.	2001	LTA
8	Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. (10816471)	Pang L.T.... Chow A.W.	2000	TNF
9	Kallikrein-kinin system activation in streptococcal toxic shock syndrome. (10880316)	Sriskandan S.... Cohen J.	2000	KNG1
10	Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. (10721486)	Kum W.W.... Chow A.W.	2000	CIITA
11	The effect of C1-esterase inhibitor in definite and suspected streptococcal toxic shock syndrome. Report of seven patients. (11126274)	Fronhoffs S.... Walger P.	2000	C1S
12	Induction of tumor necrosis factor alpha and interleukin-8 gene expression in bronchial epithelial cells by toxic shock syndrome toxin 1. (10603377)	Aubert V.... Spertini F.	2000	TNF
13	Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome--a comparative observational study. The Canadian Streptoco ccal Study Group. (10825042)	Kaul R.... Low D.E.	1999	TNF, IL6
14	Fibrinolytic changes in a patient with toxic shock syndrome; release of active u-PA. (9565810)	Haj M.A.... Bennett B.	1998	PLAU
15	Separation of function between the domains of toxic shock syndrome toxin-1. (9551921)	Wahlsten J.L.... Ramakrishnan S.	1998	TNF
16	Synoviocyte proliferation in joints of SCID mice induced by toxic shock syndrome toxin-1 stimulated T cells from patient with rheumatoid arthritis. (9195519)	Suzuki T.... Suzuki T.	1997	HTLVR
17	Toxic shock syndrome without rash in a young child: link with syndrome of hemorrhagic shock and encephalopathy? (9255204)	van Lierde S.... Van Eldere J.	1997	TNF
18	Prokaryotic production of the human T cell receptor Vbeta2 chain and binding to toxic-shock syndrome toxin-1. (8654955)	Ericson M.L.... Charron D.J.	1996	HTLVR
19	A mutation at glycine residue 31 of toxic shock syndrome toxin-1 defines a functional site critical for major histocompatibility complex class II binding and superantigenic activity. (8940217)	Kum W.W.... Chow A.W.	1996	CIITA
20	Influence of serum on zinc, toxic shock syndrome toxin-1, and lipopolysaccharide-induced production of IFN-gamma and IL-1 beta by human mononuclear cells. (7790774)	Driessen C.... Rink L.	1995	IL1B, IFNG
21	Cytokines and nitric oxide in streptococcal toxic shock syndrome (7739283)	MartA-n M.C.... Salgado A.	1995	IL1B, IL8
22	Upregulation of IgE synthesis by staphylococcal toxic shock syndrome toxin-1 in peripheral blood mononuclear cells from patients with atopic dermatitis. (8821303)	Hofer M.F.... Leung D.Y.	1995	IGHE
23	Role of a carboxy-terminal site of toxic shock syndrome toxin 1 in eliciting immune responses of human peripheral blood mononuclear cells. (7532624)	Drynda A.... KAPnig W.	1995	CD40LG, FCER2
24	Inhibition of toxic shock syndrome toxin-1-induced cytokine production and T cell activation by interleukin-10, interleukin-4, and dexamethasone. (7561220)	Krakauer T.	1995	TNF, IL2, IL4
25	Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1. (7911750)	Akatsuka H.... Uchiyama T.	1994	TNF, LTA
26	A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen. (7851957)	Ramesh N.... Geha R.	1994	HSPD1
27	Toxic shock syndrome caused by Streptococcus pyogene s (8404489)	Hohn H.... Seifert H.	1993	SERPINC1
28	Staphylococcus aureus toxic shock syndrome toxin 1 and Streptococcus pyogenes erythrogenic toxin A modulate inflammatory mediator release from human neutrophils. (8381770)	Hensler T.... KAPnig W.	1993	EDNRA
29	Superantigens associated with staphylococcal and streptococcal toxic shock syndrome are potent inducers of tumor necrosis factor-beta synthesis. (8515117)	Hackett S.P.... Stevens D.L.	1993	TNF, LTA
30	Association of phenotypic and genotypic characteristics of invasive Streptococcus pyogenes isolates with clinical components of streptococcal toxic shock syndrome. (8335368)	Talkington D.F.... Facklam R.R.	1993	MYOM2
31	Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. (1612731)	See R.H.... Chow A.W.	1992	TNF
32	Identification of HLA-DR alpha chain residues critica l for binding of the toxic shock syndrome toxin superantigen. (1460432)	Panina-Bordignon P.... Karr R.W.	1992	CIITA
33	Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. (1545128)	Scholl P.R.... Geha R.S.	1992	TNF, IL1B
34	Role of the adhesion molecule lymphocyte function associated antigen 1 in toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human monocytes. (1399006)	See R.H.... Chow A.W.	1992	TNF, IL1B
35	Staphylococcal toxic shock syndrome toxin 1-induced tumor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. (1639516)	See R.H.... Chow A.W.	1992	TNF, IL1B
36	Streptococcal toxic shock syndrome: synthesis of tumor necrosis factor and interleukin-1 by monocytes stimulated with pyrogenic exotoxin A and streptolysin O. (1569337)	Hackett S.P.... Stevens D.L.	1992	TNF, IL1B
37	Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)	Buyalos R.P.... Halme J.	1991	TNF
38	Therapy of toxic shock syndrome. (2196166)	Todd J.K.	1990	ALB
39	Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. (2542966)	Scholl P.... Chatila T.	1989	HLA-DPB1

Genes related to toxic shock syndrome according to GeneCards:

(show top 50)    (show all 57)

id	Symbol	Description	Score	GeneCards Section Context
1	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
2	IL1B	interleukin 1, beta	11.0	Publications
3	TNF	tumor necrosis factor	11.0	Publications
4	KLRD1	killer cell lectin-like receptor subfamily D, member 1	11.0
5	KLRC1	killer cell lectin-like receptor subfamily C, member 1	11.0
6	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
7	EDNRA	endothelin receptor type A	11.0	Publications
8	HMGB1	high mobility group box 1	11.0	Publications
9	CD69	CD69 molecule	11.0
10	MYOM2	myomesin (M-protein) 2, 165kDa	11.0	Publications
11	LBR	lamin B receptor	11.0
12	LACTB	lactamase, beta	11.0
13	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
14	CCL3	chemokine (C-C motif) ligand 3	11.0
15	CCL4	chemokine (C-C motif) ligand 4	11.0
16	IFNG	interferon, gamma	11.0	Publications
17	IL2	interleukin 2	11.0	Publications
18	IL1RN	interleukin 1 receptor antagonist	11.0
19	TYRL	tyrosinase-like (pseudogene)	11.0
20	HTLVR	human T-cell leukemia virus (I and II) receptor	11.0	Publications
21	SELM	selenoprotein M	11.0
22	PDE12	phosphodiesterase 12	11.0
23	SELK	selenoprotein K	11.0
24	GPR162	G protein-coupled receptor 162	11.0	Publications
25	SUMF2	sulfatase modifying factor 2	11.0
26	GML	glycosylphosphatidylinositol anchored molecule like protein	11.0
27	TST	thiosulfate sulfurtransferase (rhodanese)	11.0
28	SELO	selenoprotein O	11.0	Disorders
29	C1S	complement component 1, s subcomponent	11.0	Publications
30	RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	11.0
31	SPEG	SPEG complex locus	11.0
32	CCL28	chemokine (C-C motif) ligand 28	11.0
33	BTNL2	butyrophilin-like 2 (MHC class II associated)	11.0
34	FUT2	fucosyltransferase 2 (secretor status included)	11.0
35	GDPD4	glycerophosphodiester phosphodiesterase domain containing 4	11.0
36	CCDC6	coiled-coil domain containing 6	11.0
37	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0	Publications
38	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
39	EXOC1	exocyst complex component 1	11.0
40	SAG	S-antigen; retina and pineal gland (arrestin)	11.0
41	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
42	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
43	EDNRB	endothelin receptor type B	11.0
44	EPHA4	EPH receptor A4	11.0
45	EPHX2	epoxide hydrolase 2, cytoplasmic	11.0
46	KNG1	kininogen 1	11.0	Publications
47	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
48	PLAU	plasminogen activator, urokinase	11.0	Publications
49	SETBP1	SET binding protein 1	11.0
50	CD40LG	CD40 ligand	11.0	Publications

Pathways related to toxic shock syndrome according to GeneDecks:

(show top 50)    (show all 76)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	IL2, CCL4, CCL3
2	Graft-versus-host disease20	10.5	KLRD1, KLRC1, HLA-DPB1, IL2
3	RAR-Gamma-RXR-Alpha Degradation36	10.4	LTA, CCL3, CCL28, CCL4, IL2
4	Immune System38	10.2	CIITA, IFNG, KLRC1, KLRD1
5	OX40 Pathway36	10.2	IL4, LTA
6	Type I diabetes mellitus20	10.1	LTA, TNF, HLA-DPB1, HSPD1, IFNG, IL2
7	Antigen processing and presentation20	10.1	KLRD1, KLRC1, HLA-DPB1, CD4, CIITA
8	Th1 Differentiation37	9.7	LTA, TNF, IFNG, IL2, IL10, CD4
9	NFAT Signaling and Lymphocyte Interactions36	9.4	CCL3, CCL28, CCL4, IL4, IL2, FCER2
10	THC Differentiation Pathway36	9.3	TNF, IFNG, IL4, IL2, IL10
11	Leishmaniasis20	9.3	TNF, HLA-DPB1, IFNG, IL4, IL1B, IL10
12	Allograft rejection20	9.1	TNF, HLA-DPB1, IFNG, IL4, IL2, IL10
13	Asthma20	9.1	TNF, HLA-DPB1, IL4, IL10, CD40LG
14	African trypanosomiasis20	9.1	TNF, IFNG, IL6, IL1B, IL10
15	Immune response_MIF-mediated glucocorticoid regulation41	9.1	TNF, IFNG, IL8, IL6, IL2
16	Immune response MIF-mediated glucocorticoid regulation10	9.0	TNF, IFNG, IL8, IL6, IL2
17	IL-6 Pathway36	9.0	CCL3, CCL28, CCL4, IL8, IL4, IL10
18	Molecular Mechanisms of Cancer36	9.0	EPHA4, LTA, CCL28, IL6, IL2, CD4
19	PGC1Alpha Pathway36	8.9	CCL3, CCL28, CCL4, IL8, IL4, IL2
20	Rheumatoid arthritis20	8.9	TNF, HLA-DPB1, IFNG, CCL3, IL8, IL6
21	Immune response_MIF in innate immunity response41	8.8	TNF, IFNG, IL8, IL6, IL1B
22	T cell receptor signaling pathway20	8.8	TNF, IFNG, IL4, IL2, IL10, CD40LG
23	Tuberculosis20	8.8	TNF, HLA-DPB1, HSPD1, IFNG, IL6, IL1B
24	Regulation of eIF4 and p70S6K36	8.7	CCL3, CCL28, CCL4, IL6, IL4, IL2
25	Immune response MIF in innate immunity response10	8.7	TNF, IFNG, IL8, IL6, IL1B
26	Chagas disease (American trypanosomiasis)20	8.6	TNF, IFNG, CCL3, IL8, IL6, IL2
27	Pertussis20	8.5	C1S, TNF, IL8, IL6, IL1B, IL10
28	Rho Family GTPases36	8.4	EPHA4, LTA, CCL3, CCL28, CCL4, IL8
29	Malaria20	8.4	TNF, IFNG, IL8, IL6, IL1B, IL10
30	Intestinal immune network for IgA production20	8.3	HLA-DPB1, CCL28, IL6, IL4, IL2, IL10
31	Hematopoietic cell lineage20	8.2	TNF, IL6, IL4, IL1B, FCER2, CD4
32	Cytokine Network36	8.1	IL10, LTA, TNF, IFNG, IL8, IL6
33	MIF Mediated Glucocorticoid Regulation36	7.9	LTA, TNF, CCL3, CCL28, CCL4, IL8
34	MIF Regulation of Innate Immune Cells36	7.9	CCL28, CCL3, TNF, LTA, CCL4, IL8
35	Akt Signaling36	7.9	EPHA4, LTA, TNF, CCL3, CCL28, CCL4
36	all-trans-Retinoic Acid Signaling in Brain36	7.9	LTA, TNF, CCL3, CCL28, CCL4, IL8
37	PEDF Induced Signaling36	7.9	CCL28, CCL3, TNF, LTA, CCL4, IL8
38	PAK Pathway36	7.8	CCL28, CCL3, TNF, LTA, CCL4, IL8
39	SOCS Pathway36	7.6	CCL3, CCL28, CCL4, IL8, IL6, IL4
40	Tec Kinases Signaling36	7.6	CCL3, CCL28, CCL4, IL8, IL6, IL4
41	Glucocorticoid Receptor Signaling36	7.6	CCL3, CCL28, CCL4, IL8, IL6, IL4
42	TGF-Beta Pathway36	7.6	CCL3, CCL28, CCL4, IL8, IL6, IL4
43	STAT3 Pathway36	7.5	LTA, TNF, CCL3, CCL28, CCL4, IL8
44	ERK Signaling36	7.5	CCL28, CCL3, TNF, LTA, EPHA4, CCL4
45	MAPK Family Pathway36	7.5	LTA, TNF, CCL3, CCL28, CCL4, IL8
46	Cytokine-cytokine receptor interaction20	7.5	CCL28, CCL3, IFNG, TNF, LTA, CCL4
47	Antioxidant Action of Vitamin-C36	7.4	CCL4, CCL28, CCL3, TNF, LTA, IL8
48	Endothelin-1 Signaling Pathway36	7.4	CCL3, TNF, LTA, EDNRA, EDNRB, EPHA4
49	JAK-STAT Pathway36	7.3	EPHA4, IFNG, CCL3, CCL28, CCL4, IL8
50	p38 Signaling36	7.2	CCL28, CCL3, TNF, LTA, EPHA4, CCL4

Compounds related to toxic shock syndrome according to GeneDecks:

(show top 50)    (show all 199)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.3	CCL4, LTA, SAG, PIK3C2A
2	endotoxin32	10.2	CIITA, CCL4, CCL3, HSPD1, HMGB1, LTA
3	ionomycin32	9.9	CCL4, FCER2, CD69, KCNMA1, CCL3
4	l-nmma32	9.8	EDNRA, KCNMA1, IL1RN, IGHE, KNG1
5	calcitriol32 42 9 18 9	13.6	PLAU, ALB, IL2, LTA, FCER2
6	sb 20358032 42	10.2	TNF, PLAU, IL6, CCL4, IFNG, FCER2
7	taurine chloramine32	8.9	TNF, IL2, IL6, IFNG, IL1B, IL8
8	allergens32	8.8	CCL4, IL4, IL1RN, IL10, FCER2, CD40LG
9	vegf32	8.8	IL1RN, SERPINC1, PIK3C2A, CD40LG, IL1B, EDNRB
10	toxin-132	8.8	CIITA, IL10, IL1B, IL1RN, IL2, IL8
11	heparin32 9 18 9	11.7	CD4, IL1RN, SAG, CD69, PIK3C2A, CCL4
12	triptolide32	8.6	IL1B, IL2, IL8, CCL4, CCL3, IFNG
13	infliximab32 9 9	10.5	IL10, LBR, IL1B, IL1RN, IL4, IL6
14	lipoteichoic acid32	8.5	IL10, IL1B, IL1RN, CCL3, TNF, IL8
15	peptidoglycan32	8.4	CCL3, TNF, IL6, IL1RN, IL1B, IL10
16	chloroquine32 34 9 9	11.4	IL10, PLAU, IL4, CD4, TNF, SERPINC1
17	etanercept32 9 9	10.4	IL8, TNF, IFNG, IL6, IL1RN, IL1B
18	tarc32	8.4	TNF, IFNG, CCL3, CCL4, CD4, IGHE
19	pge232	8.4	EDNRB, KNG1, EDNRA, PLAU, KCNMA1, CIITA
20	poly(i-c)32	8.4	IFNG, CD69, IL1B, IL4, IL6, CCL3
21	prednisolone32 9 9	10.3	PIK3C2A, IL10, IL1RN, IL2, IL6, CCL4
22	prostacyclin32	8.2	TNF, PLAU, C1S, EDNRA, EDNRB, IL1B
23	rantes32	8.1	CIITA, LBR, CD4, CD40LG, IL2, IL4
24	okt332	8.1	LBR, CD40LG, FCER2, IL10, IL2, IL4
25	gm-csf32	8.1	IL4, IL6, IL2, CCL3, IL1B, IL10
26	polyinosinic-polycytidylic acid32	8.0	IL10, IL1B, IL2, IL4, IL6, IL8
27	gabexate mesilate32	8.0	SERPINC1, PLAU, TNF, IL8, IL6, IL10
28	pdtc32	8.0	TNF, IFNG, PLAU, CCL3, IL8, IL6
29	pentoxifylline32 9 9	10.0	LBR, IL1B, IL1RN, IL2, IL4, IL6
30	polymyxin b32	7.9	IL1RN, TNF, IL10, IL1B, IL4, IL8
31	mip 1alpha32	7.9	IL10, IL1B, IL4, IL6, IL8, CCL4
32	il 1032	7.8	IL6, IL8, CCL4, CCL3, IFNG, LTA
33	il-1232	7.8	IL8, IFNG, TNF, IL6, IL4, CD40LG
34	mcp 132	7.8	PLAU, IL10, IL6, IL8, CCL4, CCL3
35	histamine32 18	8.8	CCL4, KNG1, PLAU, ALB, IGHE, CCL3
36	simvastatin32 34 42 9 18 9	12.7	CCL4, TNF, IL10, CIITA, IL1RN, PIK3C2A
37	dextran sulfate32	7.6	CD40LG, ALB, PLAU, CIITA, SERPINC1, KNG1
38	thymidine32 18	8.5	LBR, CD69, FCER2, CIITA, IFNG, IL6
39	hydrocortisone32 9 9	9.4	IL1RN, IL2, IL4, IL6, IL8, CCL3
40	herbimycin a32 42	8.3	TNF, PLAU, LTA, CD69, CD4, CD40LG
41	actinomycin d32	7.3	IL8, CD69, LTA, IL6, CD40LG, IL4
42	indomethacin32 9 9	9.0	TNF, PLAU, LTA, EDNRA, EDNRB, KNG1
43	lactate32	7.0	FCER2, CD40LG, PIK3C2A, CCL3, IGHE, HSPD1
44	neopterin32	6.9	LBR, CD4, CD40LG, LTA, FCER2, IL10
45	nitric oxide32 9 18 9	9.7	LTA, IL1RN, IL6, CCL3, IL10, KNG1
46	serine32	6.6	CCL3, CCL4, IL8, LBR, IL1RN, LACTB
47	cyclosporin a32 42	7.2	LBR, CIITA, PIK3C2A, IL8, HSPD1, SAG
48	cycloheximide32	6.2	IL4, IL6, IL8, CCL4, CCL3, IGHE
49	dexamethasone32 42 34 9 9	9.9	CCL4, CCL3, IGHE, IFNG, HSPD1, HMGB1
50	tyrosine32	5.4	PLAU, KLRC1, LTA, EPHA4, KNG1, EDNRA

Cellular components related to toxic shock syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.5	TNF, IFNG, IL4, FCER2, CD40LG, CD4
2	extracellular region	GO:005576	6.8	CCL3, IFNG, ALB, HMGB1, PLAU, C1S
3	extracellular space	GO:005615	5.3	SERPINC1, IFNG, ALB, HSPD1, HMGB1, TNF

Biological processes related to toxic shock syndrome according to GeneDecks:

(show all 31)

id	Name	GO ID	Score	Top Affiliating Genes
1	chronic inflammatory response to antigenic stimulus	GO:002439	10.7	IL1RN, IL1B
2	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.6	TNF, IFNG, IL1B
3	positive regulation of membrane protein ectodomain proteolysis	GO:051044	10.5	TNF, IFNG, IL1B
4	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO:002925	10.5	LTA, TNF, FCER2
5	positive regulation of vitamin D biosynthetic process	GO:060557	10.5	TNF, IFNG
6	endothelin receptor signaling pathway	GO:086100	10.4	EDNRB, EDNRA
7	positive regulation of chronic inflammatory response to antigenic stimulus	GO:002876	10.4	LTA, TNF
8	negative regulation of growth of symbiont in host	GO:044130	10.2	LTA, TNF, IFNG, IL10
9	positive regulation of chemokine biosynthetic process	GO:045080	10.1	TNF, IFNG, IL4, IL1B
10	positive regulation of isotype switching to IgG isotypes	GO:048304	10.1	IFNG, IL4, IL2
11	positive regulation of interferon-gamma production	GO:032729	10.0	LTA, TNF, HSPD1, IL2, IL1B, CD40LG
12	neutrophil chemotaxis	GO:030593	9.9	IL1B, IL8, CCL3, IFNG
13	positive regulation of calcium-mediated signaling	GO:050850	9.8	CD4, CCL4, CCL3
14	cell surface receptor signaling pathway	GO:007166	9.8	SAG, CD4, IFNG, KLRC1, KLRD1, EDNRB
15	B cell proliferation	GO:042100	9.8	HSPD1, IL10, CD40LG
16	humoral immune response	GO:006959	9.7	IL6, IFNG, TNF, LTA
17	positive regulation of interleukin-6 production	GO:032755	9.6	TNF, HSPD1, IL6, IL1B
18	cell-cell signaling	GO:007267	9.6	IL10, IL1B, IL2, CCL4, CCL3, LTA
19	regulation of isotype switching	GO:045191	9.6	IL4, IL10
20	positive regulation of interleukin-10 production	GO:032733	9.6	HSPD1, IL4, CD40LG
21	response to carbon monoxide	GO:034465	9.6	IL10, KCNMA1
22	chemotaxis	GO:006935	9.6	IL4, CCL4, CCL28, CCL3, PLAU
23	positive regulation of apoptotic process	GO:043065	9.5	KNG1, TNF, HMGB1, HSPD1, IL1B, KCNMA1
24	positive regulation of interleukin-12 production	GO:032735	9.5	HSPD1, IFNG, CD40LG
25	positive regulation of MHC class II biosynthetic process	GO:045348	9.4	CIITA, CD40LG, IL10, IL4, IFNG
26	response to glucocorticoid stimulus	GO:051384	9.3	TNF, HMGB1, IL6, IL1RN, IL1B, IL10
27	positive regulation of T cell proliferation	GO:042102	9.3	IFNG, IL6, IL4, IL1B
28	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.9	TNF, IL6, IL4, IL1B, IL10
29	immune response	GO:006955	8.7	IGHE, CCL28, CCL4, IL8, IL4, IL2
30	negative regulation of apoptotic process	GO:043066	8.5	EDNRA, TNF, HSPD1, ALB, IL6, IL4
31	inflammatory response	GO:006954	7.8	EPHX2, KNG1, TNF, CCL3, CCL4, IL8

Molecular functions related to toxic shock syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endothelin receptor activity	GO:004962	10.2	EDNRA, EDNRB
2	chemokine activity	GO:008009	9.2	CCL3, CCL28, CCL4, IL8
3	cytokine activity	GO:005125	7.7	CD40LG, LTA, TNF, HMGB1, IFNG, CCL4