Aliases & Classifications for Toxic Shock Syndrome

MalaCards integrated aliases for Toxic Shock Syndrome:

Name: Toxic Shock Syndrome 12 72 51 14 69
Staphylococcal Toxic Shock Syndrome 69
Shock, Septic 41
Toxic Shock 12
Tss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14115
ICD10 32 A48.3 R57.2
ICD9CM 34 040.82
MeSH 41 D012772
NCIt 46 C35498
SNOMED-CT 64 18504008

Summaries for Toxic Shock Syndrome

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection, has material basis in Streptococcus pyogenes or has material basis in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has symptom fever, has symptom rash, has symptom hypotension, has symptom multiorgan failure, has symptom desquamation, has symptom vomiting, has symptom diarrhea, has symptom headache, and has symptom nonfocal neurologic abnormalities.

MalaCards based summary : Toxic Shock Syndrome, also known as staphylococcal toxic shock syndrome, is related to staphylococcal toxic shock syndrome and streptococcal toxic-shock syndrome, and has symptoms including fever, rash and hypotension. An important gene associated with Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

CDC : 3 Sepsis is the body’s extreme response to an infection. It is life-threatening and without timely treatment can rapidly cause tissue damage, organ failure, and death.

Wikipedia : 72 Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. Symptoms may include fever, rash,... more...

Related Diseases for Toxic Shock Syndrome

Diseases related to Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 staphylococcal toxic shock syndrome 33.9 CIITA HMGB1 IFNG IL1B TNF
2 streptococcal toxic-shock syndrome 32.9 C1S CXCL8 IL2 IL6 LTA MYOM2
3 fasciitis 31.1 CXCL8 IL6 TNF
4 burns 31.1 IL1B SERPINC1 TNF
5 vaginitis 30.9 CXCL8 IL1B IL6
6 necrotizing fasciitis 30.5 CXCL8 IL2 IL6 LTA MYOM2
7 pharyngitis 30.3 CXCL8 IL1B MYOM2
8 kawasaki disease 30.3 IL10 IL6 TNF
9 pericarditis 30.1 IL1B IL6 TNF
10 rheumatic fever 30.0 IL2 MYOM2 TNF
11 acute cholangitis 30.0 IL6 TREM1
12 arteries, anomalies of 29.9 IL1B IL6 SERPINC1 TNF
13 allergic hypersensitivity disease 29.9 IFNG IL10 IL4
14 sudden infant death syndrome 29.9 IL10 IL1B IL6 TNF
15 scabies 29.8 CXCL8 IL10
16 herpes zoster 29.8 IFNG IL10 IL2
17 peritonitis 29.8 CXCL8 IFNG IL10 IL1B IL6 TNF
18 bullous impetigo 29.7 EDNRA IL6
19 acute pancreatitis 29.7 CXCL8 IL10 IL6
20 reactive arthritis 29.7 IFNG IL10 IL6 TNF
21 immune suppression 29.7 IFNG IL10 IL2 IL6
22 endocarditis 29.6 CXCL8 IL10 IL6 SERPINC1 TNF
23 arthritis 29.6 CXCL8 IFNG IL10 IL1B IL6 LTA
24 hemophagocytic lymphohistiocytosis 29.6 CXCL8 IFNG IL10 TNF
25 measles 29.5 IFNG IL2 IL4
26 meningitis 29.4 CXCL8 IFNG IL10 IL1B IL6 TNF
27 dermatitis, atopic 29.2 CXCL8 IFNG IL10 IL2 IL4 TNF
28 myeloma, multiple 29.0 CXCL8 IL6 MYOM2
29 chorioamnionitis 29.0 CXCL8 IL1B IL6 TLR4 TNF
30 aspergillosis 28.9 IFNG IL10 IL4 TLR4
31 tonsillitis 28.7 CXCL8 IFNG IL1B IL2 IL4 IL6
32 pneumonia 28.5 CXCL8 IL10 IL1B IL6 TLR4 TNF
33 psoriasis 28.5 CXCL8 IFNG IL10 IL1B IL2 IL4
34 rheumatoid arthritis 27.3 CIITA CXCL8 HMGB1 IFNG IL10 IL1B
35 systemic lupus erythematosus 26.6 C1S HMGB1 IFNG IL10 IL1B IL2
36 clostridium sordellii infection 11.4
37 staphylococcal scarlet fever 11.4
38 oral tuberculosis 10.6 IL2 TNF
39 polyposis, gastric 10.6 IL1B TNF
40 juvenile spondyloarthropathy 10.6 IL2 LTA
41 scorpion envenomation 10.6 IL6 TNF
42 systemic onset juvenile idiopathic arthritis 10.6 IL1B TNF
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
44 critical limb ischemia 10.5 IL6 TNF
45 punctate inner choroidopathy 10.5 IL10 TNF
46 laryngitis 10.5 IL1B IL6 TNF
47 null-cell leukemia 10.5 IL6 LTA TNF
48 acute vascular insufficiency of intestine 10.5 IL1B IL6 TNF
49 toxicodendron dermatitis 10.5 CXCL8 IL2
50 mycoplasmal pneumonia 10.5 IFNG IL4

Graphical network of the top 20 diseases related to Toxic Shock Syndrome:



Diseases related to Toxic Shock Syndrome

Symptoms & Phenotypes for Toxic Shock Syndrome

Symptoms:

12
  • fever
  • rash
  • hypotension
  • multiorgan failure
  • desquamation
  • vomiting
  • diarrhea
  • headache
  • nonfocal neurologic abnormalities

UMLS symptoms related to Toxic Shock Syndrome:


shock without mention of trauma

MGI Mouse Phenotypes related to Toxic Shock Syndrome:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CIITA EDNRA IFNG IL10 IL1B IL2
2 homeostasis/metabolism MP:0005376 10.29 CIITA EDNRA IFNG IL10 IL1B IL2
3 immune system MP:0005387 10.27 CIITA EDNRA IFNG IL10 IL1B IL2
4 cardiovascular system MP:0005385 10.24 EDNRA IFNG IL10 IL1B IL2 IL6
5 endocrine/exocrine gland MP:0005379 10.16 CIITA EDNRA IFNG IL10 IL2 IL4
6 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL2 IL4 IL6 TLR4
7 liver/biliary system MP:0005370 10.06 TLR4 TNF IFNG IL10 IL2 IL4
8 integument MP:0010771 10.03 EDNRA IFNG IL10 IL1B IL4 IL6
9 nervous system MP:0003631 10.02 EDNRA IFNG IL10 IL1B IL4 IL6
10 neoplasm MP:0002006 9.97 IFNG IL10 IL1B IL2 IL6 TLR4
11 reproductive system MP:0005389 9.86 IL10 IL2 IL4 IL6 SERPINC1 TLR4
12 respiratory system MP:0005388 9.81 IL2 IL4 IL6 LTA TLR4 TNF
13 skeleton MP:0005390 9.7 CIITA EDNRA IFNG IL10 IL1B IL4
14 vision/eye MP:0005391 9.32 EDNRA IFNG IL10 IL2 IL4 IL6

Drugs & Therapeutics for Toxic Shock Syndrome

Drugs for Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3
Rifampin Approved Phase 4 13292-46-1 5381226 5458213
4
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
5 Antibodies Phase 4,Phase 2
6 gamma-Globulins Phase 4,Phase 2
7 Immunoglobulins Phase 4,Phase 2
8 Immunoglobulins, Intravenous Phase 4,Phase 2
9 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
10 Rho(D) Immune Globulin Phase 4,Phase 2
11 Anti-Bacterial Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Amoxicillin-Potassium Clavulanate Combination Phase 4
14 Antibiotics, Antitubercular Phase 4
15 beta-Lactamase Inhibitors Phase 4
16 Clavulanic Acid Phase 4
17 Clindamycin palmitate Phase 4
18 Clindamycin phosphate Phase 4
19 proline Nutraceutical Phase 4
20 Vaccines Phase 2,Phase 1
21
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
22
Iron Approved Phase 1 7439-89-6 23925
23
Imidazole Experimental, Investigational Phase 1 288-32-4 795
24 Adjuvants, Immunologic Phase 1
25 Antacids Phase 1
26 Anti-Ulcer Agents Phase 1
27 Gastrointestinal Agents Phase 1
28 Monophosphoryl lipid A Phase 1
29 Adrenergic Agents
30 Adrenergic Antagonists
31 Adrenergic beta-Antagonists
32 Neurotransmitter Agents
33 methicillin

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin
2 Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study Unknown status NCT02219165 Phase 2 Intravenous human immunoglobulin;Albumin
3 Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults Recruiting NCT02814708 Phase 2
4 Phase I STEBVax in Healthy Adults Completed NCT00974935 Phase 1 Aluminum hydroxide
5 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial Completed NCT02971670 Phase 1
6 rTSST-1 Variant Vaccine Phase 1 First-in-man Trail Completed NCT02340338 Phase 1
7 Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Completed NCT01717950 Phase 1
8 Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS) Completed NCT01606631
9 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
10 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
11 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
12 Pediatric Immune Response to Infectious Shock Recruiting NCT02848144
13 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128

Search NIH Clinical Center for Toxic Shock Syndrome

Cochrane evidence based reviews: shock, septic

Genetic Tests for Toxic Shock Syndrome

Anatomical Context for Toxic Shock Syndrome

MalaCards organs/tissues related to Toxic Shock Syndrome:

38
T Cells, Skin, Monocytes, Colon, B Cells, Endothelial, Neutrophil

Publications for Toxic Shock Syndrome

Articles related to Toxic Shock Syndrome:

(show top 50) (show all 709)
# Title Authors Year
1
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( 29429115 )
2018
2
The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature. ( 29366615 )
2018
3
Innate immune responses following Kawasaki disease and toxic shock syndrome. ( 29447181 )
2018
4
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
5
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. ( 29350159 )
2018
6
Toxic Shock Syndrome ( 29083727 )
2017
7
Toxic shock syndrome in paediatric thermal injuries: A case series and systematic literature review. ( 28867411 )
2017
8
Vaccine against toxic shock syndrome in a first-in-man clinical trial. ( 27918218 )
2017
9
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28580155 )
2017
10
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
11
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
12
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
13
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
14
Toxic Shock Syndrome within 24 H of an Office Hysteroscopy. ( 28706411 )
2017
15
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
16
Group A Streptococcal Peritonitis and Toxic Shock Syndrome in a Postmenopausal Woman. ( 28824068 )
2017
17
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
18
Inverse relationship between toxic shock syndrome toxin-1 antibodies and interferon-I^ and interleukin-6 in peripheral blood mononuclear cells from patients with pediatric tonsillitis caused by Staphylococcus aureus. ( 28483238 )
2017
19
Toxic shock syndrome caused by suture abscess with methicillin-resistant Staphylococcus aureus (MRSA) with late onset after Caesarean section. ( 28791216 )
2017
20
Toxic Shock Syndrome: Still a Timely Diagnosis. ( 29040243 )
2017
21
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
22
Toxic shock syndrome, tampons and laboratory standard-setting. ( 28536130 )
2017
23
Toxic shock syndrome due to community-acquired methicillin-resistant Staphylococcus aureus infection: Two case reports and a literature review in Japan. ( 28491813 )
2017
24
Septic miscarriage with toxic shock syndrome and disseminated intravascular coagulation (DIC): The role of surgery, recombinant activated factor VII and intravenous immunoglobulin (IVIG). ( 29308782 )
2017
25
Toxic shock syndrome - the seven Rs of management and treatment. ( 28646955 )
2017
26
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
27
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
28
Two Catastrophes in One Patient: Drug Reaction with Eosinophilia and Systemic Symptoms and Toxic Shock Syndrome. ( 28721327 )
2017
29
Macro- and Microvascular Parameters Following Toxic Shock Syndrome. ( 29112091 )
2017
30
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. ( 28721224 )
2017
31
The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function. ( 29229737 )
2017
32
Prevalence, comorbidities and mortality of toxic shock syndrome in United States children and adults. ( 28892185 )
2017
33
Toxic shock syndrome: A dermatological emergency. ( 28960233 )
2017
34
Case of toxic shock syndrome triggered by negative-pressure wound therapy. ( 28862320 )
2017
35
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. ( 27863161 )
2017
36
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
37
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
38
Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome. ( 28791185 )
2017
39
Poster 80 Bilateral Lower Extremity Amputation after Toxic Shock Syndrome Presents with Locked Knee: AA Case Report. ( 27672849 )
2016
40
High prevalence of toxic shock syndrome toxin-producing epidemic methicillin-resistant Staphylococcus aureus 15 (EMRSA-15) strains in Kuwait hospitals. ( 27222714 )
2016
41
Mild forms of toxic shock syndrome toxin-1-mediated exanthematous disease related to Staphylococcus aureus infection. ( 26923257 )
2016
42
Recurrent Streptococcus agalactiae Toxic Shock Syndrome Triggered by a Tumor Necrosis Factor-I+ Inhibitor. ( 27803422 )
2016
43
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
44
Preliminary investigation of human serum albumin-VI^ inhibition on toxic shock syndrome induced by staphylococcus enterotoxin B inA vitro and inA vivo. ( 26792715 )
2016
45
Veno-arterial extracorporeal membrane oxygenation for Streptococcus pyogenes toxic shock syndrome in pregnancy. ( 26758056 )
2016
46
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
47
Lipopolysaccharide-Induced Toxic Shock Syndrome in Rabbits. ( 26676037 )
2016
48
A Term Infant of Neonatal Toxic Shock Syndrome-Like Exanthematous Disease Complicated with Hemophagocytic Syndrome. ( 27760897 )
2016
49
Invariant NKT cells are pathogenic in the HLA-DR4-transgenic humanized mouse model of toxic shock syndrome and can be targeted to reduce morbidity. ( 28035011 )
2016
50
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016

Variations for Toxic Shock Syndrome

Expression for Toxic Shock Syndrome

Search GEO for disease gene expression data for Toxic Shock Syndrome.

Pathways for Toxic Shock Syndrome

Pathways related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 C1S CIITA CXCL8 HMGB1 IFNG IL10
2
Show member pathways
13.77 CXCL8 EDNRA IFNG IL10 IL1B IL2
3
Show member pathways
13.63 CXCL8 IFNG IL10 IL1B IL2 IL4
4
Show member pathways
13.52 CXCL8 IL10 IL1B IL2 IL4 IL6
5
Show member pathways
13.48 CIITA CXCL8 IFNG IL10 IL1B IL2
6
Show member pathways
13.39 CXCL8 IL10 IL1B IL2 IL4 IL6
7
Show member pathways
13.32 HMGB1 IFNG IL1B IL2 IL4 TLR4
8 12.94 CXCL8 EDNRA IFNG IL2 IL4 IL6
9
Show member pathways
12.93 CIITA CXCL8 IFNG IL10 IL1B IL2
10
Show member pathways
12.84 CXCL8 HMGB1 IFNG IL1B IL6 TNF
11
Show member pathways
12.83 IL2 IL4 IL6 LTA TNF
12
Show member pathways
12.82 CIITA CXCL8 IFNG IL1B IL2 IL4
13
Show member pathways
12.81 IL1B IL2 IL6 LTA TLR4 TNF
14
Show member pathways
12.76 IFNG IL10 IL1B IL2 IL4 IL6
15
Show member pathways
12.72 IFNG IL10 IL1B IL2 IL6 TNF
16
Show member pathways
12.71 IFNG IL10 IL2 IL4 TNF
17 12.71 CIITA IFNG IL10 IL1B IL2 IL4
18
Show member pathways
12.67 CXCL8 IFNG IL10 IL1B IL2 IL6
19
Show member pathways
12.59 IFNG IL10 IL1B IL2 IL4 IL6
20
Show member pathways
12.55 IFNG IL2 IL4 TNF
21
Show member pathways
12.5 IFNG IL10 IL2 IL4 IL6
22
Show member pathways
12.5 IFNG IL1B IL2 IL4 IL6 TNF
23
Show member pathways
12.49 CXCL8 IFNG IL1B IL4 IL6 TNF
24 12.47 IL2 IL6 LTA TNF
25
Show member pathways
12.42 CXCL8 IFNG IL1B IL6 TLR4 TNF
26
Show member pathways
12.41 CIITA IFNG IL10 IL1B IL4 TLR4
27 12.38 CIITA IFNG IL10 IL1B IL6 TLR4
28
Show member pathways
12.35 HMGB1 IFNG IL1B TLR4 TNF
29
Show member pathways
12.33 CXCL8 IL6 TLR4 TNF
30
Show member pathways
12.33 CXCL8 IFNG IL1B IL4 IL6 TLR4
31 12.32 CXCL8 IL10 IL1B IL6 TNF
32 12.26 IFNG IL6 TLR4 TNF
33 12.17 IFNG IL10 IL2 IL4 IL6 TNF
34 12.16 CXCL8 IL10 IL1B IL4 IL6 TNF
35
Show member pathways
12.09 IFNG IL1B IL2 IL4
36 12.07 IL1B IL6 LTA TNF
37 12.06 CXCL8 IFNG IL1B IL6
38 12.06 CXCL8 IL1B LTA TLR4 TNF
39
Show member pathways
12.04 IFNG IL1B IL4 IL6 TLR4
40 12.04 CXCL8 IFNG IL1B IL6 TLR4 TNF
41 12.03 CXCL8 IL1B IL6 TNF
42 12.02 IL1B IL4 IL6 TNF
43 12 CXCL8 IFNG IL1B IL6 TLR4
44 12 CXCL8 IFNG IL10 IL1B IL6 TLR4
45 12 CXCL8 IFNG IL1B IL2 IL4 IL6
46 11.98 CXCL8 IFNG IL2 IL4 IL6
47 11.95 IFNG IL10 IL2 IL6
48 11.94 IFNG IL6 TLR4
49
Show member pathways
11.94 CXCL8 IFNG IL2 IL4 TNF
50 11.91 CXCL8 IL2 TLR4

GO Terms for Toxic Shock Syndrome

Cellular components related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CXCL8 HMGB1 IFNG IL10 IL1B IL2
2 extracellular region GO:0005576 9.44 C1S CXCL8 HMGB1 IFNG IL10 IL1B

Biological processes related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.98 IL10 IL1B LTA TLR4
2 positive regulation of protein phosphorylation GO:0001934 9.96 IFNG IL1B IL2 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 IL1B IL6 TLR4 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.92 IL10 IL1B IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.89 IL6 LTA TNF
6 regulation of insulin secretion GO:0050796 9.87 IFNG IL1B TNF
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 IFNG IL2 IL6
8 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
9 inflammatory response GO:0006954 9.86 CIITA CXCL8 HMGB1 IL10 IL1B IL6
10 positive regulation of JNK cascade GO:0046330 9.85 HMGB1 IL1B TLR4 TNF
11 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IL10 IL6 TLR4 TNF
12 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL4 IL6
13 positive regulation of B cell proliferation GO:0030890 9.82 IL2 IL4 TLR4
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR4 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR4 TNF
16 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR4 TNF
17 negative regulation of interferon-gamma production GO:0032689 9.79 HMGB1 IL10 TLR4
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 IFNG IL1B TLR4 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR4 TNF
20 humoral immune response GO:0006959 9.77 IFNG IL6 LTA TNF TREM1
21 positive regulation of interleukin-12 production GO:0032735 9.76 HMGB1 IFNG TLR4
22 positive regulation of NF-kappaB import into nucleus GO:0042346 9.75 IL1B TLR4 TNF
23 positive regulation of chemokine production GO:0032722 9.74 IL6 TLR4 TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
26 regulation of regulatory T cell differentiation GO:0045589 9.72 IFNG IL2
27 positive regulation of interferon-gamma production GO:0032729 9.72 IL1B IL2 LTA TLR4 TNF
28 negative regulation of collagen biosynthetic process GO:0032966 9.71 CIITA IL6
29 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
30 positive regulation of immunoglobulin secretion GO:0051024 9.71 IL2 IL6
31 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
32 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 LTA TNF
33 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
34 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
37 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL10 IL1B TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
41 type 2 immune response GO:0042092 9.67 IL10 IL4
42 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
43 sequestering of triglyceride GO:0030730 9.66 IL1B TNF
44 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.65 LTA TNF
45 regulation of isotype switching GO:0045191 9.65 IL10 IL4
46 regulation of receptor activity GO:0010469 9.65 CXCL8 HMGB1 IFNG IL10 IL1B IL2
47 receptor biosynthetic process GO:0032800 9.63 IL10 TNF
48 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.61 LTA TNF
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.6 IFNG TNF
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG IL1B TNF

Molecular functions related to Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CXCL8 HMGB1 IFNG IL10 IL1B IL2
2 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6
3 protein binding GO:0005515 10.03 C1S CIITA CXCL8 EDNRA HMGB1 IFNG

Sources for Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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