MCID: TXP001
MIFTS: 62

Toxoplasmosis malady

Infectious diseases category

Summaries for Toxoplasmosis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and hepatitis. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are PTEN Pathway and Metabolism. The drugs sulfadiazine and trimethoprim sulfate and the compounds alpha-linolenic acid and u 73343 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC:3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia:63 Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects... more...

Aliases & Classifications for Toxoplasmosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

toxoplasmosis 8 10 44 33 60
multisystemic disseminated toxoplasmosis 60
disseminated toxoplasmosis 8


External Ids:

Disease Ontology8 DOID:9965
MeSH34 D014123
ICD9CM27 130, 130.9
NCIt39 C3418
ICD1025 B58, B58.8, B58.9

Related Diseases for Toxoplasmosis

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Toxoplasmosis family:

toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1congenital toxoplasmosis31.8CD79A, CD40LG
2hepatitis30.3CD40LG
3tuberculosis30.2IL17A, CD79A, IRGM, DHFR, ADK
4cryptosporidiosis30.1DHFR, CD79A
5uveitis30.1IL17A
6encephalitis30.0IL17A, IDO1
7lupus erythematosus29.9CD79A, CD40LG
8vasculitis29.9CD79A, IL17A, CD40LG
9rheumatoid arthritis29.7COL2A1, IDO1, DHFR, IL17A, PLA2G10, CD40LG
10arthritis29.7COL2A1, IDO1, IL17A
11hepatitis b29.7CD79A, DHFR
12lyme disease29.7CD40LG
13candidiasis29.7CD79A
14cerebritis10.7
15chorioretinitis10.5
16retinitis10.5
17ocular toxoplasmosis10.3
18choroiditis10.3
19acquired immunodeficiency syndrome10.3
20rubella10.3
21pneumocystosis10.2
22syphilis10.2
23louping ill10.2
24hydrocephalus10.2
25neuroretinitis10.1
26diabetes insipidus10.1
27toxocariasis10.1
28listeriosis10.1
29cataract10.1
30iridocyclitis10.1
31meningitis10.1
32schizophrenia10.1
33leptospirosis10.0
34sarcocystosis10.0
35brucellosis10.0
36nephrotic syndrome10.0
37hypersensitivity reaction type ii disease10.0CD79A, IDO1, CD40LG, IL17A, LAT
38atherosclerosis10.0IL17A, CD40LG, PLA2G10, IDO1
39immunodeficiency, common variable, 710.0DHFR, CD79A, CD40LG
40immunoglobulin g deficiency10.0CD40LG, CD79A
41connective tissue disease10.0CD79A, CD40LG
42autoimmune hemolytic anemia10.0CD79A, CD40LG
43selective iga deficiency disease10.0CD40LG, CD79A
44crohn's disease10.0IRGM
45immunodeficiency, centromere instability and facial anomalies syndrome10.0CD79A, CD40LG
46immunoglobulin alpha deficiency10.0CD79A, CD40LG
47thrombocytopenia10.0CD40LG, CD79A
48guillain-barre syndrome10.0CD40LG
49immunodeficiency with hyper igm type 110.0CD79A, CD40LG
50asthma10.0IL17A, IDO1, CD79A

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to toxoplasmosis

Clinical Features for Toxoplasmosis

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Drugs & Therapeutics for Toxoplasmosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Toxoplasmosis

Search NIH Clinical Center for Toxoplasmosis

Search CenterWatch for Toxoplasmosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Toxoplasmosis

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Anatomical Context for Toxoplasmosis

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32MalaCards
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MalaCards organs/tissues related to Toxoplasmosis:

32
Brain, Eye, Testes, T cells, Placenta, Pituitary, Heart, B cells, Kidney, Spinal cord, Nk cells, Colon, Retina, Fetal brain, Tonsil, Endothelial, Monocytes, Myeloid, Breast, Whole blood, Spleen, Lymph node, Skin, Medulla oblongata

Animal Models for Toxoplasmosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Toxoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.0ADK, IRGM, CD40LG, CD79A, IL17A, ABCA4

Publications for Toxoplasmosis

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50PubMed
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Articles related to Toxoplasmosis:

(show top 50)    (show all 1313)
idTitleAuthorsYear
1
Risk factors for ocular toxoplasmosis in Brazil. (23507508)
2014
2
Toxoplasmosis among pregnant women: high seroprevalence and risk factors in Kinshasa, Democratic Republic of Congo. (24144134)
2014
3
Features to validate cerebral toxoplasmosis. (23856881)
2013
4
Significance of maternal screening for toxoplasmosis, rubella, cytomegalovirus and herpes simplex virus infection in cases of fetal growth restriction. (23107457)
2013
5
Disseminated toxoplasmosis in non-allografted patients with hematologic malignancies: report of two cases and literature review. (23595587)
2013
6
Toxoplasmosis involving the rostral medulla oblongata bilaterally in a non-HIV patient. (23415420)
2013
7
Prevalence and risk factors associated to ovine toxoplasmosis in northeastern Brazil. (23856735)
2013
8
The close relationship between toxoplasmosis and kidney function. (23152315)
2012
9
Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult. (23487348)
2012
10
Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study. (21599563)
2012
11
Atovaquone ameliorate gastrointestinal toxoplasmosis complications in a pregnancy model. (22936182)
2012
12
Toxoplasmosis in the fetus and newborn: an update on prevalence, diagnosis and treatment. (22943404)
2012
13
Is it all cerebral toxoplasmosis? (22265631)
2012
14
The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis. (22194951)
2011
15
Evaluation of Pichia pastoris-expressed recombinant rhoptry protein 2 of Toxoplasma gondii for its application in diagnosis of toxoplasmosis. (21896809)
2011
16
Toxoplasmosis and horse meat, France. (21762609)
2011
17
Immunodiagnosis in cerebrospinal fluid of cerebral toxoplasmosis and HIV-infected patients using Toxoplasma gondii excreted/secreted antigens. (21907524)
2011
18
Contribution of laboratory methods in diagnosing clinically suspected ocular toxoplasmosis in Brazilian patients. (21683267)
2011
19
Importance of high IgG anti-Toxoplasma gondii titers and PCR detection of T. gondii DNA in peripheral blood samples for the diagnosis of AIDS-related cerebral toxoplasmosis: a case-control study. (21861006)
2011
20
Unusual manifestation of cutaneous toxoplasmosis in a HIV-positive patient. (21399585)
2010
21
Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. (20582922)
2010
22
Use of CD25 as an immunohistochemical marker for acquired ocular toxoplasmosis. (21225130)
2010
23
Prevalence of toxoplasmosis, HIV, syphilis and rubella in a population of puerperal women using Whatman 903 filter paper. (20428650)
2010
24
An outbreak of lethal toxoplasmosis in pigs in the Gansu province of China. (20453223)
2010
25
Trimethoprim/Sulfamethoxazole and azithromycin combination therapy for ocular toxoplasmosis. (19657985)
2009
26
Imaging of congenital toxoplasmosis macular scars with optical coherence tomography. (19262439)
2009
27
Congenital toxoplasmosis: the importance of the western blot method to avoid unnecessary therapy in potentially infected newborns. (18616630)
2008
28
Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth. (17362565)
2007
29
Visual function in human ocular toxoplasmosis. (16987904)
2007
30
Prospective study of pregnants and babies with risk of congenital toxoplasmosis in municipal district of Rio Grande do Sul]. (12937726)
2003
31
Acquired ocular toxoplasmosis in an elderly patient. (11827006)
2001
32
Human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL SCID) models of toxoplasmosis. (11114971)
2000
33
Discordant prenatal diagnosis of congenital toxoplasmosis in a dizygotic pregnancy. (9643415)
1998
34
Congenital toxoplasmosis due to maternal reinfection during pregnancy. (9114425)
1997
35
Toxoplasmic chorioretinitis in the setting of acute acquired toxoplasmosis. (8842263)
1996
36
Congenital toxoplasmosis among premature infants with different clinical pictures in Saudi Arabia. (7844430)
1994
37
Adult respiratory distress syndrome associated with disseminated toxoplasmosis. (7948525)
1994
38
Immunoglobulin-A detection and the investigation of clinical toxoplasmosis. (8474118)
1993
39
Diagnostic and therapeutic dilemmas in ocular toxoplasmosis. (22827193)
1993
40
Comparison of the diagnostic usefulness of immunoglobulins A and M in acute toxoplasmosis]. (8159880)
1993
41
Rat model of congenital toxoplasmosis. (1879945)
1991
42
Prevention of congenital toxoplasmosis; experience in The Netherlands. (2628371)
1989
43
Herpes zoster ophthalmicus, contralateral hemiplegia, and recurrent ocular toxoplasmosis in a patient with acquired immune deficiency syndrome-related complex. (2531159)
1989
44
Myositis in mice with congenital toxoplasmosis. (3256280)
1988
45
Pityriasis lichenoides et varioliformis acuta and acquired toxoplasmosis. (3609416)
1987
46
Congenital ocular toxoplasmosis. (6827609)
1983
47
Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy. (7175624)
1982
48
Congenital toxoplasmosis: a serologic screening of 963 mothers and their children at birth. (7037652)
1981
49
OCULAR TOXOPLASMOSIS: A CASE REPORT. (14114985)
1964
50
Experimentally induced ocular toxoplasmosis in rabbits. (13342349)
1956

Genetic Variations for Toxoplasmosis

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Expression for genes affiliated with Toxoplasmosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for genes affiliated with Toxoplasmosis

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.8PLA2G10, LAT, PLA2G12B, PLA2G2E, PLA2G3, CD79A
2
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10.8PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10, ADK
3
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10.8PLA2G10, CD79A, PLA2G12B, PLA2G2E, LAT, PLA2G4B
4
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10.8PLA2G2E, PLA2G3, LAT, PLA2G12B, PLA2G10, HLA-DOB
5
Hide members
10.7PLA2G2E, PLA2G10, LAT, PLA2G12B, PLA2G3
610.7PLA2G10, PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3
7
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10.7PLA2G2E, PLA2G12B, PLA2G10, PLA2G3, PLA2G4B
8
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10.7PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
9
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10.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E, PLA2G4B
10
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10.7PLA2G12B, PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
11
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10.7IL17A, LAT, CD40LG, CD79A
12
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10.7CD40LG, HLA-DOB, IRGM, IL17A
1310.7PLA2G3, PLA2G10, PLA2G2E, PLA2G12B
1410.7PLA2G10, PLA2G2E, PLA2G3, PLA2G12B
15
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10.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
1610.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
17
Immune response NFAT in immune response
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10.6LAT, HLA-DOB, CD79A
18
Anandamide biosynthesis and metabolism
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10.6PLA2G10, PLA2G2E, PLA2G3

Compounds for genes affiliated with Toxoplasmosis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1alpha-linolenic acid44 11 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
2u 733435911.1PLA2G12B, PLA2G4B, PLA2G3, PLA2G10, PLA2G2E
3m-3m3fbs5911.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
4fipi5911.1PLA2G10, PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3
5d6095911.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
6edelfosine44 5912.1PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
7linoleic acid44 28 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
8arginine4411.0COL2A1, IDO1, CD40LG, CD79A, DHFR, ADK
9stearic acid44 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
10pge24411.0IDO1, CD40LG, CD79A, IL17A, PLA2G10
11palmitic acid28 11 2413.0PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
12arachidonic acid44 28 11 2414.0PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
13myristic acid44 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
14pteridine4411.0IDO1, DHFR, ADK
15pneumococcal4411.0DHFR, CD79A, CD40LG
16glycerol44 11 2413.0CD79A, DHFR, PLA2G10, PLA2G2E
17mannan4410.9IL17A, CD79A, CD40LG
18sulfolipid i4410.9CD79A, CD40LG
19sandoglobulin4410.9CD40LG, CD79A
20anti-fungal4410.9CD40LG, CD79A, DHFR
21ascorbic acid44 2411.9DHFR, CD79A, CD40LG, COL2A1
22neopterin4410.9CD79A, CD40LG, IDO1
23theophylline44 28 11 2413.8CD40LG, CD79A, ADK
24calcium44 49 11 2413.7COL2A1, IDO1, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B
25dexamethasone44 49 28 1113.7IL17A, CD79A, CD40LG, IDO1, COL2A1
26vancomycin44 1111.7CD79A, CD40LG
27blys4410.7CD40LG, CD79A
28tuberculin4410.6CD79A, CD40LG
29praziquantel44 1111.6CD79A, CD40LG
30hemocyanin4410.3CD40LG, CD79A

GO Terms for genes affiliated with Toxoplasmosis

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16Gene Ontology
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Biological processes related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylglycerol acyl-chain remodelingGO:03614810.9PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
2phosphatidylethanolamine acyl-chain remodelingGO:03615210.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
3phosphatidylcholine acyl-chain remodelingGO:03615110.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
4lipid catabolic processGO:01604210.8PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
5inflammatory responseGO:00695410.8PLA2G2E, PLA2G4B, IL17A, CD40LG, IRGM
6glycerophospholipid biosynthetic processGO:04647410.8PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
7phosphatidylserine acyl-chain remodelingGO:03615010.8PLA2G2E, PLA2G4B, PLA2G10
8phosphatidic acid biosynthetic processGO:00665410.6PLA2G10, PLA2G4B, PLA2G2E
9phosphatidylinositol acyl-chain remodelingGO:03614910.6PLA2G2E, PLA2G10
10phospholipid metabolic processGO:00664410.6PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
11B cell proliferationGO:04210010.3CD79A, CD40LG

Molecular functions related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00550910.7PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E, PLA2G10
2phospholipase A2 activityGO:00462310.5PLA2G2E, PLA2G12B, PLA2G10
3calcium-dependent phospholipase A2 activityGO:04749810.3PLA2G4B, PLA2G3

Products for genes affiliated with Toxoplasmosis

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  • Antibodies
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Sources for Toxoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet