MCID: TXP001
MIFTS: 65

Toxoplasmosis malady

Infectious diseases, Rare diseases, Fetal diseases, Neuronal diseases categories
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Summaries for Toxoplasmosis

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and rubella. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Malaria. The drugs sulfadiazine and trimethoprim sulfate and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are renal/urinary system and cellular.

Disease Ontology:8 A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC:4 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia:65 Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects... more...

Aliases & Classifications for Toxoplasmosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

toxoplasmosis 8 10 45 34 62
multisystemic disseminated toxoplasmosis 62
disseminated toxoplasmosis 8


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Disease Ontology8 DOID:9965
ICD9CM27 130.9, 130
NCIt40 C3418
MeSH35 D014123
ICD1025 B58, B58.8, B58.9

Related Diseases for Toxoplasmosis

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Toxoplasmosis family:

toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1congenital toxoplasmosis32.0CD79A, CD40LG
2rubella30.6CD40LG, CD79A
3syphilis30.5CD79A
4cryptosporidiosis30.3CD79A, DHFR
5encephalitis30.2IDO1, IL17A
6tuberculosis30.2TLR9, TLR1, DHFR, IL17A, NOD2, CD79A
7schistosomiasis30.1CD79A, CD40LG
8lupus erythematosus30.1CD40LG, CD79A, TLR9
9vasculitis30.1CD40LG, CD79A, IL17A
10herpes simplex30.0TLR9, IDO1, DHFR, CD79A
11q fever29.9CD79A
12malaria29.9DHFR, TLR9
13lyme disease29.9CD40LG, TLR1
14arthritis29.8IL17A, COL2A1
15leukemia29.7CD40LG, CD79A, IL17A, DHFR, IDO1
16pneumonia29.7TLR5, IDO1, DHFR, IL17A, CD79A
17melanoma29.7TLR9, IDO1, DHFR, COL2A1
18systemic lupus erythematosus29.6TLR9, TLR5, IL17A, NOD2, CD79A, CD40LG
19rheumatoid arthritis29.5TLR9, IDO1, DHFR, IL17A, COL2A1, NOD2
20ocular toxoplasmosis11.1
21cerebritis10.7
22chorioretinitis10.5
23retinitis10.5
24acquired immunodeficiency syndrome10.4
25choroiditis10.4
26pneumocystosis10.3
27hepatitis10.2
28louping ill10.2
29hydrocephalus10.2
30diabetes insipidus10.1
31toxocariasis10.1
32listeriosis10.1
33neuroretinitis10.1
34cataract10.1
35iridocyclitis10.1
36schizophrenia10.1
37pityriasis lichenoides10.1
38scrub typhus10.1CD40LG
39hemorrhagic fever10.1CD40LG
40macroglobulinemia10.1CD79A
41polyarteritis nodosa10.1CECR1
42immunoglobulin g deficiency10.1CD79A, CD40LG
43selective iga deficiency disease10.1CD79A, CD40LG
44immunodeficiency, centromere instability and facial anomalies syndrome10.1CD40LG, CD79A
45immunoglobulin alpha deficiency10.1CD79A, CD40LG
46immunodeficiency with hyper igm type 110.1CD40LG, CD79A
47cryoglobulinemia10.1CD40LG, CD79A
48spondylitis10.1NOD2
49autoimmune hemolytic anemia10.1CD79A, CD40LG
50infectious mononucleosis10.1CD79A, CD40LG

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to toxoplasmosis

Symptoms for Toxoplasmosis

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Drugs & Therapeutics for Toxoplasmosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Toxoplasmosis

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Toxoplasmosis

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Anatomical Context for Toxoplasmosis

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33MalaCards
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MalaCards organs/tissues related to Toxoplasmosis:

33
Brain, Eye, Testes, T cells, Placenta, Pituitary, Kidney, Spinal cord, B cells, Heart, Endothelial, Retina, Tonsil, Fetal brain, Nk cells, Monocytes, Myeloid, Skin, Breast, Colon, Whole blood, Lymph node, Spleen, Medulla oblongata

Animal Models for Toxoplasmosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Toxoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5TLR9, IL17A, COL2A1, CD79A, CD40LG
2MP:00053848.2CD40LG, CD79A, NOD2, IDO1, TLR5, TLR9
3MP:00053817.8TLR9, TLR5, IL17A, COL2A1, NOD2
4MP:00053976.9TLR9, TLR1, TLR5, IDO1, IL17A, NLRP1
5MP:00053876.5CD40LG, TLR9, TLR1, TLR5, IDO1, IL17A
6MP:00053766.3ABCA4, TLR9, TLR5, IDO1, IL17A, NLRP1

Publications for Toxoplasmosis

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52PubMed
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Articles related to Toxoplasmosis:

(show top 50)    (show all 1307)
idTitleAuthorsYear
1
Chorioretinitis as the first sign of acquired toxoplasmosis transmitted from donor following kidney transplantation: case report and review of the literature. (23323579)
2013
2
The global burden of congenital toxoplasmosis: a systematic review. (23825877)
2013
3
Case report of a neonate with ocular toxoplasmosis due to congenital infection: estimation of the percentage of ocular toxoplasmosis in Greece caused by congenital or acquired infection. (24293989)
2013
4
IgG4 specific to Toxoplasma gondii excretory/secretory antigens in serum and/or cerebrospinal fluid support the cerebral toxoplasmosis diagnosis in HIV-infected patients. (23811152)
2013
5
A Rapid Diagnostic Test for Toxoplasmosis using Recombinant Antigenic N-terminal Half of SAG1 Linked with Intrinsically Unstructured Domain of GRA2 Protein. (24327774)
2013
6
Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives. (24276426)
2013
7
Fatal disseminated toxoplasmosis in an immunocompetent cat. (23718784)
2013
8
Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis. (22541791)
2012
9
Imaging in ocular toxoplasmosis. (22954935)
2012
10
Cerebral toxoplasmosis: unusual MRI findings. (22920346)
2012
11
Seroprevalence for toxoplasmosis in individuals living in north west Tuscany: access to Toxo-test in central Italy. (21964589)
2012
12
A dedicated surveillance network for congenital toxoplasmosis in Greece, 2006-2009: assessment of the results. (23173875)
2012
13
Transplantation of skin grafts and organs infected with Toxoplasma gondii as a source of toxoplasmosis in immunocompromised mice. (21519126)
2011
14
Diagnostic approach to ocular toxoplasmosis. (21770803)
2011
15
Sudden sensorineural hearing loss: subclinical viral and toxoplasmosis infections as aetiology and how they alter the clinical course. (21389742)
2011
16
Congenital toxoplasmosis--a report on the Danish neonatal screening programme 1999-2007. (20585987)
2010
17
Outbreak of acquired ocular toxoplasmosis involving 248 patients. (20065213)
2010
18
Toxoplasmosis in Serbia: time for an action plan. (21073140)
2010
19
Congenital toxoplasmosis from a chronically infected woman with reactivation of retinochoroiditis during pregnancy. (19918624)
2010
20
In utero and at birth diagnosis of congenital toxoplasmosis: use of likelihood ratios for clinical management. (19952858)
2010
21
Clinical relevance of placenta examination for the diagnosis of congenital toxoplasmosis. (19858771)
2010
22
Update on the treatment of ocular toxoplasmosis. (19319237)
2009
23
Risk factors predisposing to toxoplasmosis in chronic renal failure patients and renal transplant recipients. (20120759)
2009
24
Disease burden of congenital toxoplasmosis. (17479945)
2007
25
Fluorescein and indocyanine green angiography in ocular toxoplasmosis. (16673136)
2006
26
Prenatal diagnosis of congenital toxoplasmosis: is there a chance for the pregnancies in settings without surveillance programs? (16260894)
2005
27
Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth. (15663394)
2005
28
Active ocular toxoplasmosis in Turkish patients: a report on 109 cases. (17318320)
2005
29
Some molecular aspects in schistosomiasis mansoni and toxoplasmosis. (16333889)
2005
30
Prenatal diagnosis of congenital toxoplasmosis. (12454967)
2002
31
Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 children. (11585075)
2001
32
Evidence for a compartmentalized B cell response as characterized by IgG epitope specificity in human ocular toxoplasmosis. (11714789)
2001
33
Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. (11376068)
2001
34
Ecological comparison of the risks of mother-to-child transmission and clinical manifestations of congenital toxoplasmosis according to prenatal treatment protocol. (11561963)
2001
35
Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice. (9916110)
1999
36
Congenital toxoplasmosis: efficacy of maternal treatment with spiramycin alone. (9602252)
1998
37
Comparative value of polymerase chain reaction and conventional biological tests for the prenatal diagnosis of congenital toxoplasmosis. (1485688)
1992
38
Orally administered 566C80 for treatment of ocular toxoplasmosis in a patient with the acquired immunodeficiency syndrome. (1543229)
1992
39
Ocular toxoplasmosis in patients with the acquired immunodeficiency syndrome. (3195645)
1988
40
Pityriasis lichenoides et varioliformis acuta and acquired toxoplasmosis. (3609416)
1987
41
Helminthiasis and toxoplasmosis among exotic mammals at the Santiago National Zoo. (3505930)
1986
42
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
43
Congenital ocular toxoplasmosis. (6827609)
1983
44
Ocular toxoplasmosis in Malaysia. (6672558)
1983
45
Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy. (7175624)
1982
46
In vitro lymphocyte stimulation with specific antigen in congenital toxoplasmosis. (7031854)
1981
47
Immunosuppression in toxoplasmosis: studies in sheep with vaccines for chlamydial abortion and louping-ill virus. (6278695)
1981
48
Hydrops fetales and congenital toxoplasmosis. Value of direct immunofluorescence test. (337198)
1978
49
Ocular toxoplasmosis in an adult receiving long-term corticosteroid therapy. (1252177)
1976
50
Disseminated cytomegalic inclusion disease and disseminated toxoplasmosis in an adult with myeloid metaplasia; report of a case. (13292382)
1956

Variations for Toxoplasmosis

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Expression for genes affiliated with Toxoplasmosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for genes affiliated with Toxoplasmosis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 61Tocris Bioscience, 5Cell Signaling Technology, 57SinoBiological, 54R&D Systems
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Pathways related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CD40LG, CD79A
29.8CD40LG, TLR9
39.8IDO1, TLR9
4
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.4CD40LG, CD79A, IL17A
5
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4TLR5, TLR1, TLR9
6
Show member pathways
9.4TLR5, TLR1, TLR9
7
Show member pathways
9.4TLR5, TLR1, TLR9
89.4TLR5, TLR1, TLR9
9
Show member pathways
9.4TLR5, TLR1, TLR9
109.4TLR9, TLR1, TLR5
11
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.4TLR9, TLR1, TLR5
129.3TLR9, TLR1, NLRP1
139.2TLR9, TLR1, NOD2
14
Show member pathways
9.1TLR9, TLR1, TLR5, CD40LG
15
Show member pathways
9.1TLR9, TLR1, TLR5, CD79A
16
Show member pathways
IL27-mediated signaling events38
8.8IL17A, TLR5, TLR1, TLR9
17
Show member pathways
8.8IL17A, TLR5, TLR1, TLR9
18
Show member pathways
8.7CD40LG, NOD2, IL17A, TLR5
19
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.2TLR9, TLR1, TLR5, NLRP1, NOD2

Compounds for genes affiliated with Toxoplasmosis

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Toxoplasmosis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.4CD40LG, CD79A
2sandoglobulin4510.4CD79A, CD40LG
3gamma globulin4510.3CD79A, CD40LG
4vancomycin45 1111.3CD79A, CD40LG
5blys4510.3CD40LG, CD79A
6tuberculin4510.3CD40LG, CD79A
7praziquantel45 1111.3CD40LG, CD79A
8hemocyanin4510.3CD79A, CD40LG
9gliadin4510.3CD40LG, CD79A
10pmma4510.2CD40LG, CD79A
11pteridine4510.2IDO1, DHFR
12silicone4510.2CD79A, CD40LG
13sulfamethoxazole51 45 1112.2CD40LG, DHFR
14hydroxychloroquine45 1111.2CD40LG, TLR9
15resiquimod45 6111.2TLR1, TLR9
16pneumococcal4510.1DHFR, CD79A, CD40LG
17loxoribine45 2911.1TLR5, TLR9
18dapsone45 3 51 1113.1CD79A, DHFR
19anti-fungal4510.1CD40LG, CD79A, DHFR
20okt34510.1CD40LG, CD79A
21neopterin4510.0IDO1, CD79A, CD40LG
22glutaraldehyde4510.0CD40LG, CD79A
23indoleamine4510.0TLR9, IDO1
24folate4510.0CD40LG, CD79A, DHFR
25lactulose4510.0NOD2, CD79A
26cardiolipin45 1111.0CD40LG, CD79A
27chloroquine45 3 51 29 1114.0TLR9, DHFR, CD79A
28mannan459.9CD40LG, CD79A, IL17A
29adenine45 24 1111.8TLR9, IDO1, DHFR
30flagellin45 2910.8TLR5, TLR1, TLR9
31lipoteichoic acid459.8TLR5, TLR1, TLR9
32poly(i-c)459.8IDO1, TLR5, TLR9
33muramyl dipeptide45 2910.7NLRP1, NOD2
34inosine monophosphate459.7IDO1, TLR9
35sulfasalazine29 45 51 1112.7CD40LG, CD79A
36ascorbic acid45 2410.6CD40LG, CD79A, COL2A1, DHFR
37methotrexate51 45 1111.6DHFR, IL17A, CD79A
38chloramphenicol45 3 51 1112.6COL2A1, DHFR, IDO1
39pge2459.5CD40LG, CD79A, IL17A, IDO1
40indomethacin45 29 61 1112.4IL17A, CD79A, CD40LG
41infliximab45 51 1111.4IDO1, IL17A, NOD2
42mannose459.4CD79A, NOD2, IL17A
43tacrolimus45 51 1111.4IL17A, NOD2, CD79A
44arginine459.3IDO1, DHFR, COL2A1, CD79A, CD40LG
45peptidoglycan45 2910.2NOD2, TLR5, TLR1, TLR9
46endotoxin459.1TLR9, IL17A, NOD2, CD40LG
47dexamethasone45 51 29 1112.0IDO1, IL17A, COL2A1, CD79A, CD40LG
48rantes459.0TLR9, TLR5, IDO1, IL17A, CD40LG
49oligonucleotide458.9TLR9, IDO1, IL17A, COL2A1
50nitric oxide45 24 1110.6NOD2, COL2A1, IL17A, IDO1, TLR9

GO Terms for genes affiliated with Toxoplasmosis

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16Gene Ontology
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Cellular components related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CD40LG, CD79A, IL17A

Biological processes related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.0CD40LG, CD79A
2positive regulation of toll-like receptor signaling pathwayGO:03412310.0TLR9, TLR5
3positive regulation of interleukin-8 productionGO:0327579.8TLR9, TLR5
4positive regulation of type 2 immune responseGO:0028309.8IDO1, NOD2
5positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR9, NOD2
6maintenance of gastrointestinal epitheliumGO:0302779.7TLR9, NOD2
7positive regulation of interleukin-10 productionGO:0327339.6NOD2, TLR9
8response to muramyl dipeptideGO:0324959.6NOD2, NLRP1
9positive regulation of interleukin-1 beta secretionGO:0507189.5NOD2, NLRP1
10positive regulation of tumor necrosis factor productionGO:0327609.5NOD2, TLR9
11positive regulation of interleukin-6 productionGO:0327559.4TLR9, NOD2
12MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3NOD2, TLR5, TLR9
13regulation of inflammatory responseGO:0507279.3NOD2, NLRP1
14defense response to bacteriumGO:0427429.2TLR9, NLRP1, NOD2
15positive regulation of interleukin-12 productionGO:0327359.2CD40LG, NOD2, IDO1, TLR9
16toll-like receptor signaling pathwayGO:0022249.1NOD2, TLR5, TLR1, TLR9
17nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.0NOD2, NLRP1
18inflammatory responseGO:0069548.9TLR9, TLR1, TLR5, IL17A, CD40LG
19innate immune responseGO:0450878.5TLR9, TLR1, TLR5, NLRP1, NOD2

Molecular functions related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.7TLR5, TLR9
2transmembrane signaling receptor activityGO:0048889.2CD79A, TLR1, TLR9

Products for genes affiliated with Toxoplasmosis

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Sources for Toxoplasmosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet