MCID: TXP001
MIFTS: 59

Toxoplasmosis malady

Infectious category

Summaries for Toxoplasmosis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and tuberculosis. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are PTEN Pathway and Metabolism. The drugs sulfadiazine and trimethoprim sulfate and the compounds alpha-linolenic acid and u 73343 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and spleen, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC:3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia:64 Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects... more...

Aliases & Classifications for Toxoplasmosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

toxoplasmosis 8 10 45 34 61
multisystemic disseminated toxoplasmosis 61
disseminated toxoplasmosis 8


External Ids:

Disease Ontology8 DOID:9965
MeSH35 D014123
ICD9CM27 130, 130.9
NCIt40 C3418
ICD1025 B58, B58.8, B58.9

Related Diseases for Toxoplasmosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the congenital toxoplasmosis family:

toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1congenital toxoplasmosis31.8CD79A, CD40LG
2tuberculosis30.3IRGM, CD79A, DHFR, IL17A, ADK
3cryptosporidiosis30.1CD79A, DHFR
4uveitis30.1IL17A
5vasculitis30.0IL17A, CD79A, CD40LG
6arthritis29.7IL17A, IDO1, COL2A1
7hepatitis b29.7DHFR, CD79A
8lyme disease29.7CD40LG
9blindness29.7ABCA4, COL2A1
10ocular toxoplasmosis11.1
11acquired immunodeficiency syndrome10.4
12rubella10.3
13pneumocystosis10.3
14congenital human immunodeficiency virus10.3
15syphilis10.2
16congenital cytomegalovirus10.2
17cytomegalovirus infection10.2
18neuroretinitis10.1
19diabetes insipidus10.1
20toxocariasis10.1
21listeriosis10.1
22n syndrome10.1
23pityriasis lichenoides10.1
24congenital central diabetes insipidus10.1
25hepatitis c10.1
26leptospirosis10.1
27sarcocystosis10.1
28cytomegalic inclusion disease10.1
29cataract, congenital10.1
30myelitis10.0
31subacute sclerosing panencephalitis10.0
32sensorineural hearing loss10.0
33lymphocytic choriomeningitis10.0
34pancytopenia10.0
35encephalitozoonosis10.0
36herpes zoster10.0
37cerebral lymphoma10.0
38adult syndrome10.0
39obstructive hydrocephalus10.0
40retinal vasculitis10.0
41hepatitis a10.0
42hydranencephaly10.0
43trypanosomiasis10.0
44congenital rubella10.0
45rheumatoid arthritis10.0COL2A1, IDO1, CD40LG, CD79A, DHFR, IL17A
46hypersensitivity reaction type ii disease10.0IDO1, CD40LG, CD79A, IL17A, LAT
47atherosclerosis10.0PLA2G10, IL17A, CD40LG, IDO1
48immunodeficiency, common variable, 710.0DHFR, CD79A, CD40LG
49lupus erythematosus10.0CD79A, CD40LG
50immunoglobulin g deficiency10.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to toxoplasmosis

Clinical Features for Toxoplasmosis

Drugs & Therapeutics for Toxoplasmosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Toxoplasmosis

Search NIH Clinical Center for Toxoplasmosis

Search CenterWatch for Toxoplasmosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Toxoplasmosis

Anatomical Context for Toxoplasmosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Toxoplasmosis:

33
Whole blood, Lymph node, Spleen, Brain, Retina, Spinal cord, Heart, Small intestine, Colon, Kidney, Breast, Skin, Placenta, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Medulla oblongata, Pituitary

Animal Models for Toxoplasmosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Toxoplasmosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.0ADK, IRGM, CD40LG, CD79A, IL17A, ABCA4

Publications for Toxoplasmosis

Sources:
51PubMed
See all sources

Articles related to Toxoplasmosis:

(show top 50)    (show all 1313)
idTitleAuthorsYear
1
New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. (24200675)
2014
2
Chorioretinitis as the first sign of acquired toxoplasmosis transmitted from donor following kidney transplantation: case report and review of the literature. (23323579)
2013
3
Toxoplasmosis preventive behavior and related knowledge among Saudi pregnant women: an exploratory study. (23985115)
2013
4
Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. (24275372)
2013
5
Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology. (22776427)
2012
6
Toxoplasmosis: BVA says risk from cats should not be overplayed. (22983520)
2012
7
Toxoplasmosis: new challenges for an old disease. (22222265)
2012
8
Ocular manifestations of systemic disease: toxoplasmosis. (23047172)
2012
9
Serologic survey of toxoplasmosis in Seoul and Jeju-do, and a brief review of its seroprevalence in Korea. (23230325)
2012
10
Diagnosis of congenital toxoplasmosis by polymerase chain reaction. (22664453)
2012
11
Cytokine profile in murine toxoplasmosis. (21771408)
2011
12
Real-time quantitative PCR in cerebral toxoplasmosis diagnosis of Brazilian human immunodeficiency virus-infected patients. (20150319)
2010
13
A case of recurrence of congenital ocular toxoplasmosis with frosted branch angiitis (ocular toxoplasmosis with frosted branch angiitis). (21319040)
2010
14
Frequency and factors associated with recurrences of ocular toxoplasmosis in a referral centre in Colombia. (19429576)
2009
15
Pars plana vitrectomy for vitreoretinal complications of ocular toxoplasmosis. (19882570)
2009
16
A case of congenital toxoplasmosis whose mother demonstrated serum low IgG avidity and positive tests for multiplex-nested PCR in the amniotic fluid. (19708184)
2009
17
Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis. (18445459)
2008
18
Congenital toxoplasmosis: priorities for further health promotion action. (17964621)
2008
19
The antitoxoplasma gondii antibodies incidence to the different ocular diseases patients cases of human ocular toxoplasmosis infections in Romania. (19354169)
2008
20
Seroprevalence of toxoplasmosis in pregnant women in Rabat, Morocco]. (17982862)
2007
21
Effects of sulfamethoxazole on murine ocular toxoplasmosis in interferon-gamma knockout mice. (16384972)
2006
22
Isolated central diabetes insipidus in a newborn with congenital toxoplasmosis. (16562592)
2006
23
Prenatal diagnosis of congenital toxoplasmosis. (12454967)
2002
24
Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 children. (11585075)
2001
25
Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with ocular toxoplasmosis. (11726627)
2001
26
Unusual retinal vasculitis in a patient with protein S deficiency and systemic toxoplasmosis: a case report. (11344718)
2001
27
Retinal detachment in ocular toxoplasmosis. (10647716)
2000
28
Vasoproliferative retinal tumors associated with peripheral chorioretinal scars in presumed congenital toxoplasmosis. (10654174)
1999
29
Common questions about the diagnosis and management of congenital toxoplasmosis. (20212976)
1999
30
Reconsidering the pathogenesis of ocular toxoplasmosis. (10577593)
1999
31
Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA? (10445343)
1999
32
Immunoglobulin G avidity in diagnosis of toxoplasmic lymphadenopathy and ocular toxoplasmosis. (10391853)
1999
33
Prenatal diagnosis of congenital toxoplasmosis by PCR: extended experience. (9602492)
1998
34
Angiographic findings in eyes with active ocular toxoplasmosis. (8926648)
1995
35
Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection. (8418062)
1993
36
Other infections of the choroid and retina. Toxoplasmosis, histoplasmosis, Lyme disease, syphilis, tuberculosis, and ocular toxocariasis. (1460269)
1992
37
Congenital toxoplasmosis: a large survey in western Australia. (2046568)
1991
38
Coincidence of congenital toxoplasmosis and biliary atresia in an infant. (1791508)
1991
39
Fuchs's heterochromic cyclitis in congenital ocular toxoplasmosis. (2043584)
1991
40
Antigen-specific lymphocyte transformation in congenital toxoplasmosis. (2411653)
1985
41
Congenital toxoplasmosis: a prospective survey in Brussels. (6722061)
1984
42
Minocycline in experimental ocular toxoplasmosis in the rabbit. (7072799)
1982
43
Fuchs' heterochromic cyclitis and ocular toxoplasmosis. (7201246)
1982
44
Longitudinal study of serum antibody responses to retinal antigens in acute ocular toxoplasmosis. (7039327)
1982
45
Congenital toxoplasmosis: long-term follow-up. (7099676)
1982
46
Congenital toxoplasmosis in Indonesia. (941244)
1976
47
Serological diagnosis of congenital toxoplasmosis. (1097468)
1975
48
Ocular toxoplasmosis, trigeminal herpes zoster and pulmonary tuberculosis in a patient with Hodgkin's disease. (1079591)
1975
49
Diagnosis and treatment of pneumocystosis and toxoplasmosis in the immunosuppressed host. (4580723)
1973
50
Experimental ocular toxoplasmosis in mice: immunofluorescent demonstration of toxoplasma antigens in the early stage of infection. (4929160)
1970

Genetic Variations for Toxoplasmosis

Expression for genes affiliated with Toxoplasmosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for genes affiliated with Toxoplasmosis

Sources:
52QIAGEN, 54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8COL2A1, CD79A, PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
2
Hide members
10.8DHFR, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
3
Hide members
10.8CD79A, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
4
Hide members
10.8HLA-DOB, PLA2G10, PLA2G3, PLA2G12B, PLA2G2E, LAT
5
Hide members
10.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E, LAT
6
Hide members
10.7PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
7
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
8
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
910.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
10
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
11
Hide members
10.7CD40LG, CD79A, IL17A, LAT
12
Hide members
10.7IL17A, CD40LG, HLA-DOB, IRGM
13
Hide members
10.7PLA2G2E, PLA2G12B, PLA2G3, PLA2G10
1410.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
1510.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
1610.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
17
Immune response NFAT in immune response
Hide members
10.6HLA-DOB, CD79A, LAT
18
Anandamide biosynthesis and metabolism
Hide members
10.6PLA2G2E, PLA2G3, PLA2G10

Compounds for genes affiliated with Toxoplasmosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1alpha-linolenic acid45 11 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
2u 733436011.1PLA2G12B, PLA2G4B, PLA2G3, PLA2G10, PLA2G2E
3m-3m3fbs6011.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
4fipi6011.1PLA2G10, PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3
5d6096011.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
6edelfosine45 6012.1PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
7linoleic acid45 29 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
8arginine4511.0COL2A1, IDO1, CD40LG, CD79A, DHFR, ADK
9stearic acid45 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
10pge24511.0IDO1, CD40LG, CD79A, IL17A, PLA2G10
11palmitic acid29 11 2413.0PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
12arachidonic acid45 29 11 2414.0PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
13myristic acid45 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
14pteridine4511.0IDO1, DHFR, ADK
15pneumococcal4511.0DHFR, CD79A, CD40LG
16glycerol45 11 2413.0CD79A, DHFR, PLA2G10, PLA2G2E
17mannan4510.9IL17A, CD79A, CD40LG
18sulfolipid i4510.9CD79A, CD40LG
19sandoglobulin4510.9CD40LG, CD79A
20anti-fungal4510.9CD40LG, CD79A, DHFR
21ascorbic acid45 2411.9DHFR, CD79A, CD40LG, COL2A1
22neopterin4510.9CD79A, CD40LG, IDO1
23theophylline45 29 11 2413.8CD40LG, CD79A, ADK
24calcium45 50 11 2413.7COL2A1, IDO1, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B
25dexamethasone45 50 29 1113.7IL17A, CD79A, CD40LG, IDO1, COL2A1
26vancomycin45 1111.7CD79A, CD40LG
27blys4510.7CD40LG, CD79A
28tuberculin4510.6CD79A, CD40LG
29praziquantel45 1111.6CD79A, CD40LG
30hemocyanin4510.3CD40LG, CD79A

GO Terms for genes affiliated with Toxoplasmosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylglycerol acyl-chain remodelingGO:03614810.9PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
2phosphatidylethanolamine acyl-chain remodelingGO:03615210.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
3phosphatidylcholine acyl-chain remodelingGO:03615110.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
4lipid catabolic processGO:01604210.8PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
5inflammatory responseGO:00695410.8PLA2G2E, PLA2G4B, IL17A, CD40LG, IRGM
6glycerophospholipid biosynthetic processGO:04647410.8PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
7phosphatidylserine acyl-chain remodelingGO:03615010.8PLA2G2E, PLA2G4B, PLA2G10
8phosphatidic acid biosynthetic processGO:00665410.6PLA2G10, PLA2G4B, PLA2G2E
9phosphatidylinositol acyl-chain remodelingGO:03614910.6PLA2G2E, PLA2G10
10phospholipid metabolic processGO:00664410.6PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
11B cell proliferationGO:04210010.3CD79A, CD40LG

Molecular functions related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00550910.7PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E, PLA2G10
2phospholipase A2 activityGO:00462310.5PLA2G2E, PLA2G12B, PLA2G10
3calcium-dependent phospholipase A2 activityGO:04749810.3PLA2G4B, PLA2G3

Products for genes affiliated with Toxoplasmosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Toxoplasmosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet