MCID: TXP001
MIFTS: 66

Toxoplasmosis malady

Infectious diseases, Rare diseases, Fetal diseases, Neuronal diseases categories
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Summaries for Toxoplasmosis

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MedlinePlus:33 Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards based summary: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and syphilis. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Malaria. The drugs sulfadiazine and trimethoprim sulfate and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are renal/urinary system and cellular.

Disease Ontology:8 A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC:3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia:65 Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects... more...

Aliases & Classifications for Toxoplasmosis

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Toxoplasmosis, Aliases & Descriptions:

Name: Toxoplasmosis 8 10 44 33 62
Multisystemic Disseminated Toxoplasmosis 62
 
Disseminated Toxoplasmosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases, Fetal diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:9965
MeSH34 D014123
ICD9CM27 130.9, 130
NCIt39 C3418
ICD1025 B58, B58.8, B58.9

Related Diseases for Toxoplasmosis

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Diseases in the Congenital Toxoplasmosis family:

toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1congenital toxoplasmosis32.5CD79A, CD40LG
2syphilis31.1CD79A
3rubella31.1CD40LG, CD79A
4cryptosporidiosis30.8CD79A, DHFR
5encephalitis30.6IDO1, IL17A
6schistosomiasis30.6CD79A, CD40LG
7q fever30.6CD79A
8polyarteritis nodosa30.5CECR1
9lupus erythematosus30.4CD40LG, CD79A, TLR9
10malaria30.3DHFR, TLR9
11vasculitis30.3CD40LG, CD79A, IL17A
12lyme disease30.3CD40LG, TLR1
13common variable immunodeficiency30.2CD40LG, CD79A, TLR9
14herpes simplex30.2TLR9, IDO1, DHFR, CD79A
15arthritis30.0IL17A, COL2A1
16tuberculosis29.8TLR9, TLR1, DHFR, IL17A, NOD2, CD79A
17leukemia29.6CD40LG, CD79A, IL17A, DHFR, IDO1
18pneumonia29.6TLR5, IDO1, DHFR, IL17A, CD79A
19melanoma29.5TLR9, IDO1, DHFR, COL2A1
20systemic lupus erythematosus29.2TLR9, TLR5, IL17A, NOD2, CD79A, CD40LG
21rheumatoid arthritis28.8TLR9, IDO1, DHFR, IL17A, COL2A1, NOD2
22ocular toxoplasmosis11.1
23cerebritis10.7
24scrub typhus10.6CD40LG
25chorioretinitis10.6
26retinitis10.5
27hemorrhagic fever10.5CD40LG
28macroglobulinemia10.5CD79A
29immunoglobulin g deficiency10.4CD79A, CD40LG
30selective iga deficiency disease10.4CD79A, CD40LG
31immunodeficiency, centromere instability and facial anomalies syndrome10.4CD40LG, CD79A
32immunoglobulin alpha deficiency10.4CD79A, CD40LG
33immunodeficiency with hyper igm type 110.4CD40LG, CD79A
34bruton-type agammaglobulinemia10.4CD40LG, CD79A
35cryoglobulinemia10.4CD40LG, CD79A
36spondylitis10.4NOD2
37acquired immunodeficiency syndrome10.4
38choroiditis10.4
39autoimmune hemolytic anemia10.4CD79A, CD40LG
40infectious mononucleosis10.4CD79A, CD40LG
41agammaglobulinemia10.4CD40LG, CD79A
42inflammatory bowel disease10.4CD79A, TLR5
43antiphospholipid syndrome10.3CD79A, CD40LG
44measles10.3CD40LG, CD79A
45polyneuropathy10.3CD40LG, CD79A
46pneumocystosis10.3
47lupus nephritis10.3CD40LG, CD79A, TLR9
48connective tissue disease10.3CD40LG, CD79A, TLR9
49primary biliary cirrhosis10.3TLR9, CD79A, CD40LG
50hepatitis10.2

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to toxoplasmosis

Symptoms for Toxoplasmosis

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Drugs & Therapeutics for Toxoplasmosis

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Drug clinical trials:

Search ClinicalTrials for Toxoplasmosis

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Toxoplasmosis

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Anatomical Context for Toxoplasmosis

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MalaCards organs/tissues related to Toxoplasmosis:

32
Brain, Eye, Testes, T cells, Placenta, Kidney, Spinal cord, Heart, B cells, Pituitary, Whole blood, Lymph node, Spleen, Retina, Colon, Thyroid, Breast, Skin, Tonsil, Myeloid, Monocytes, Nk cells, Endothelial, Fetal brain, Medulla oblongata

Animal Models for Toxoplasmosis or affiliated genes

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MGI Mouse Phenotypes related to Toxoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5TLR9, IL17A, COL2A1, CD79A, CD40LG
2MP:00053848.2CD40LG, CD79A, NOD2, IDO1, TLR5, TLR9
3MP:00053817.8TLR9, TLR5, IL17A, COL2A1, NOD2
4MP:00053976.9TLR9, TLR1, TLR5, IDO1, IL17A, NLRP1
5MP:00053876.5CD40LG, TLR9, TLR1, TLR5, IDO1, IL17A
6MP:00053766.3ABCA4, TLR9, TLR5, IDO1, IL17A, NLRP1

Publications for Toxoplasmosis

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Articles related to Toxoplasmosis:

(show top 50)    (show all 1351)
idTitleAuthorsYear
1
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
2
What information do Dutch midwives give clients about toxoplasmosis, listeriosis and cytomegalovirus prevention? An exploratory study of videotaped consultations. (24820638)
2014
3
Cuban Ocular Toxoplasmosis Epidemiology Study (COTES): incidence and prevalence of ocular toxoplasmosis in Central Cuba. (25253767)
2014
4
Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis. (24787053)
2014
5
Chorioretinitis as the first sign of acquired toxoplasmosis transmitted from donor following kidney transplantation: case report and review of the literature. (23323579)
2013
6
The global burden of congenital toxoplasmosis: a systematic review. (23825877)
2013
7
Case report of a neonate with ocular toxoplasmosis due to congenital infection: estimation of the percentage of ocular toxoplasmosis in Greece caused by congenital or acquired infection. (24293989)
2013
8
IgG4 specific to Toxoplasma gondii excretory/secretory antigens in serum and/or cerebrospinal fluid support the cerebral toxoplasmosis diagnosis in HIV-infected patients. (23811152)
2013
9
A Rapid Diagnostic Test for Toxoplasmosis using Recombinant Antigenic N-terminal Half of SAG1 Linked with Intrinsically Unstructured Domain of GRA2 Protein. (24327774)
2013
10
Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives. (24276426)
2013
11
Fatal disseminated toxoplasmosis in an immunocompetent cat. (23718784)
2013
12
Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis. (22541791)
2012
13
Imaging in ocular toxoplasmosis. (22954935)
2012
14
Cerebral toxoplasmosis: unusual MRI findings. (22920346)
2012
15
Seroprevalence for toxoplasmosis in individuals living in north west Tuscany: access to Toxo-test in central Italy. (21964589)
2012
16
Transplantation of skin grafts and organs infected with Toxoplasma gondii as a source of toxoplasmosis in immunocompromised mice. (21519126)
2011
17
Diagnostic approach to ocular toxoplasmosis. (21770803)
2011
18
Sudden sensorineural hearing loss: subclinical viral and toxoplasmosis infections as aetiology and how they alter the clinical course. (21389742)
2011
19
Congenital toxoplasmosis--a report on the Danish neonatal screening programme 1999-2007. (20585987)
2010
20
Outbreak of acquired ocular toxoplasmosis involving 248 patients. (20065213)
2010
21
Toxoplasmosis in Serbia: time for an action plan. (21073140)
2010
22
Congenital toxoplasmosis from a chronically infected woman with reactivation of retinochoroiditis during pregnancy. (19918624)
2010
23
In utero and at birth diagnosis of congenital toxoplasmosis: use of likelihood ratios for clinical management. (19952858)
2010
24
Clinical relevance of placenta examination for the diagnosis of congenital toxoplasmosis. (19858771)
2010
25
Update on the treatment of ocular toxoplasmosis. (19319237)
2009
26
Disease burden of congenital toxoplasmosis. (17479945)
2007
27
Fluorescein and indocyanine green angiography in ocular toxoplasmosis. (16673136)
2006
28
Prenatal diagnosis of congenital toxoplasmosis: is there a chance for the pregnancies in settings without surveillance programs? (16260894)
2005
29
Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth. (15663394)
2005
30
Active ocular toxoplasmosis in Turkish patients: a report on 109 cases. (17318320)
2005
31
Some molecular aspects in schistosomiasis mansoni and toxoplasmosis. (16333889)
2005
32
Prenatal diagnosis of congenital toxoplasmosis. (12454967)
2002
33
Serological rebound in congenital toxoplasmosis: long-term follow-up of 133 children. (11585075)
2001
34
Evidence for a compartmentalized B cell response as characterized by IgG epitope specificity in human ocular toxoplasmosis. (11714789)
2001
35
Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. (11376068)
2001
36
Ecological comparison of the risks of mother-to-child transmission and clinical manifestations of congenital toxoplasmosis according to prenatal treatment protocol. (11561963)
2001
37
Fas-FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice. (9916110)
1999
38
Congenital toxoplasmosis: efficacy of maternal treatment with spiramycin alone. (9602252)
1998
39
Comparative value of polymerase chain reaction and conventional biological tests for the prenatal diagnosis of congenital toxoplasmosis. (1485688)
1992
40
Pityriasis lichenoides et varioliformis acuta and acquired toxoplasmosis. (3609416)
1987
41
Helminthiasis and toxoplasmosis among exotic mammals at the Santiago National Zoo. (3505930)
1986
42
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
43
Congenital ocular toxoplasmosis. (6827609)
1983
44
Ocular toxoplasmosis in Malaysia. (6672558)
1983
45
Congenital toxoplasmosis associated with acquired oculomotor nerve (CN III) palsy. (7175624)
1982
46
In vitro lymphocyte stimulation with specific antigen in congenital toxoplasmosis. (7031854)
1981
47
Immunosuppression in toxoplasmosis: studies in sheep with vaccines for chlamydial abortion and louping-ill virus. (6278695)
1981
48
Hydrops fetales and congenital toxoplasmosis. Value of direct immunofluorescence test. (337198)
1978
49
Ocular toxoplasmosis in an adult receiving long-term corticosteroid therapy. (1252177)
1976
50
Disseminated cytomegalic inclusion disease and disseminated toxoplasmosis in an adult with myeloid metaplasia; report of a case. (13292382)
1956

Variations for Toxoplasmosis

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Expression for genes affiliated with Toxoplasmosis

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Expression patterns in normal tissues for genes affiliated with Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for genes affiliated with Toxoplasmosis

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Pathways related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CD40LG, CD79A
29.8CD40LG, TLR9
39.8IDO1, TLR9
4
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4CD40LG, CD79A, IL17A
5
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4TLR5, TLR1, TLR9
6
Show member pathways
9.4TLR5, TLR1, TLR9
7
Show member pathways
9.4TLR5, TLR1, TLR9
89.4TLR5, TLR1, TLR9
9
Show member pathways
9.4TLR5, TLR1, TLR9
109.4TLR9, TLR1, TLR5
11
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4TLR9, TLR1, TLR5
129.3TLR9, TLR1, NLRP1
139.2TLR9, TLR1, NOD2
14
Show member pathways
9.1TLR9, TLR1, TLR5, CD40LG
15
Show member pathways
9.1TLR9, TLR1, TLR5, CD79A
16
Show member pathways
IL27-mediated signaling events37
8.8IL17A, TLR5, TLR1, TLR9
17
Show member pathways
8.8IL17A, TLR5, TLR1, TLR9
18
Show member pathways
8.7CD40LG, NOD2, IL17A, TLR5
19
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.2TLR9, TLR1, TLR5, NLRP1, NOD2

Compounds for genes affiliated with Toxoplasmosis

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Compounds related to Toxoplasmosis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.4CD40LG, CD79A
2sandoglobulin4410.4CD79A, CD40LG
3gamma globulin4410.3CD79A, CD40LG
4vancomycin44 1111.3CD79A, CD40LG
5blys4410.3CD40LG, CD79A
6tuberculin4410.3CD40LG, CD79A
7praziquantel44 1111.3CD40LG, CD79A
8hemocyanin4410.3CD79A, CD40LG
9gliadin4410.3CD40LG, CD79A
10pmma4410.2CD40LG, CD79A
11pteridine4410.2IDO1, DHFR
12silicone4410.2CD79A, CD40LG
13sulfamethoxazole50 44 1112.2CD40LG, DHFR
14hydroxychloroquine44 1111.2CD40LG, TLR9
15resiquimod44 6111.2TLR1, TLR9
16pneumococcal4410.1DHFR, CD79A, CD40LG
17loxoribine44 2811.1TLR5, TLR9
18dapsone44 2 50 1113.1CD79A, DHFR
19anti-fungal4410.1CD40LG, CD79A, DHFR
20okt34410.1CD40LG, CD79A
21neopterin4410.0IDO1, CD79A, CD40LG
22glutaraldehyde4410.0CD40LG, CD79A
23indoleamine4410.0TLR9, IDO1
24folate4410.0CD40LG, CD79A, DHFR
25lactulose4410.0NOD2, CD79A
26cardiolipin44 1111.0CD40LG, CD79A
27chloroquine44 2 50 28 1114.0TLR9, DHFR, CD79A
28mannan449.9CD40LG, CD79A, IL17A
29adenine44 24 1111.8TLR9, IDO1, DHFR
30flagellin44 2810.8TLR5, TLR1, TLR9
31lipoteichoic acid449.8TLR5, TLR1, TLR9
32poly(i-c)449.8IDO1, TLR5, TLR9
33muramyl dipeptide44 2810.7NLRP1, NOD2
34inosine monophosphate449.7IDO1, TLR9
35sulfasalazine28 44 50 1112.7CD40LG, CD79A
36ascorbic acid44 2410.6CD40LG, CD79A, COL2A1, DHFR
37methotrexate50 44 1111.6DHFR, IL17A, CD79A
38chloramphenicol44 2 50 1112.6COL2A1, DHFR, IDO1
39pge2449.5CD40LG, CD79A, IL17A, IDO1
40indomethacin44 28 61 1112.4IL17A, CD79A, CD40LG
41infliximab44 50 1111.4IDO1, IL17A, NOD2
42mannose449.4CD79A, NOD2, IL17A
43tacrolimus44 50 1111.4IL17A, NOD2, CD79A
44arginine449.3IDO1, DHFR, COL2A1, CD79A, CD40LG
45peptidoglycan44 2810.2NOD2, TLR5, TLR1, TLR9
46endotoxin449.1TLR9, IL17A, NOD2, CD40LG
47dexamethasone44 50 28 1112.0IDO1, IL17A, COL2A1, CD79A, CD40LG
48rantes449.0TLR9, TLR5, IDO1, IL17A, CD40LG
49oligonucleotide448.9TLR9, IDO1, IL17A, COL2A1
50nitric oxide44 24 1110.6NOD2, COL2A1, IL17A, IDO1, TLR9

GO Terms for genes affiliated with Toxoplasmosis

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Cellular components related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CD40LG, CD79A, IL17A

Biological processes related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.0CD40LG, CD79A
2positive regulation of toll-like receptor signaling pathwayGO:03412310.0TLR9, TLR5
3positive regulation of interleukin-8 productionGO:0327579.8TLR9, TLR5
4positive regulation of type 2 immune responseGO:0028309.8IDO1, NOD2
5positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.7TLR9, NOD2
6maintenance of gastrointestinal epitheliumGO:0302779.7TLR9, NOD2
7positive regulation of interleukin-10 productionGO:0327339.6NOD2, TLR9
8response to muramyl dipeptideGO:0324959.6NOD2, NLRP1
9positive regulation of interleukin-1 beta secretionGO:0507189.5NOD2, NLRP1
10positive regulation of tumor necrosis factor productionGO:0327609.5NOD2, TLR9
11positive regulation of interleukin-6 productionGO:0327559.4TLR9, NOD2
12MyD88-dependent toll-like receptor signaling pathwayGO:0027559.3NOD2, TLR5, TLR9
13regulation of inflammatory responseGO:0507279.3NOD2, NLRP1
14defense response to bacteriumGO:0427429.2TLR9, NLRP1, NOD2
15positive regulation of interleukin-12 productionGO:0327359.2CD40LG, NOD2, IDO1, TLR9
16toll-like receptor signaling pathwayGO:0022249.1NOD2, TLR5, TLR1, TLR9
17nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.0NOD2, NLRP1
18inflammatory responseGO:0069548.9TLR9, TLR1, TLR5, IL17A, CD40LG
19innate immune responseGO:0450878.5TLR9, TLR1, TLR5, NLRP1, NOD2

Molecular functions related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.7TLR5, TLR9
2transmembrane signaling receptor activityGO:0048889.2CD79A, TLR1, TLR9

Products for genes affiliated with Toxoplasmosis

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Sources for Toxoplasmosis

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3CDC
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25ICD10
26ICD10 via Orphanet
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