Toxoplasmosis malady

MedlinePlus: Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention²³

MalaCards: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and headache. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 and Development_Alpha-2 adrenergic receptor activation of ERK. The drugs sulfamethoxazole and trimethoprim and the compounds rhc 80267 and obaa have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.⁶

CDC: Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness. Toxoplasmosis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.²

Wikipedia: Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects...⁴⁴ more...

Aliases & Descriptions:

toxoplasmosis 6 8 32 23 43 multisystemic disseminated toxoplasmosis 43

disseminated toxoplasmosis 6

Diseases related to toxoplasmosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 654)

id	Related Disease	Score	Top Affiliating Genes
1	congenital toxoplasmosis	35.6	CECR1, CD79A, CD40LG, COL2A1, ABCA4
2	headache	26.3	CD40LG, IL1B, IL4, IFNG, IDO1, GNAI1
3	immunodeficiency	25.2	PIK3CD, MYD88, CIITA, SAG, CD79A, CD4
4	schistosomiasis	23.9	BCL2, CD79A, CD4, CD40LG, IL10, IL4
5	malaria	21.0	MYD88, UBE2D1, CD4, CD40LG, CD40, FDXR
6	cerebritis	18.4	PIK3R1, PIK3CG, RELA, CNST, MYD88, BCL2
7	pneumocystosis	14.0	CD4, CASP9, DHFR, DHPS
8	immunodeficiency with hyper igm type 1	14.0	CD79A, CD40LG, CD40, IL4
9	agammaglobulinemia	13.9	CD79A, CD40LG, CD40, IL4
10	immune defect due to absence of thymus	13.9	CD79A, CD40LG, CD40, IL10, IL4, IFNGR1
11	cicatricial pemphigoid	13.9	LAMA3, LAMC2, CD79A, ITGA6
12	junctional epidermolysis bullosa	13.9	LAMA3, LAMB3, LAMC1, LAMC2, ITGA6
13	invasive aspergillosis	13.9	LAMB4, CD79A, IL17A, IFNG, TLR4
14	selective iga deficiency disease	13.9	CD79A, CD40LG, IL10, IL4
15	multifocal motor neuropathy	13.8	CD40LG, IL10, IL4, IFNG
16	iritis	13.8	CD79A, CD40LG, HLA-B, PLA2G2D
17	hypohidrotic ectodermal dysplasia	13.8	CHUK, IRAK4, IKBKG, NFKBIA
18	chronic mucocutaneous candidiasis	13.8	CD79A, IL10, IL17A, IL4, IFNG, STAT1
19	bullous pemphigoid	13.8	CIITA, LAMA3, LAMB3, LAMC2, CD79A, ITGA6
20	berylliosis	13.7	IFNG, HLA-DPA1, HLA-DPB1, HLA-DRB1
21	junctional epidermolysis bullosa, herlitz type	13.7	LAMA3, LAMB3, LAMC2
22	autoimmune thyroiditis	13.7	CIITA, CD40, IL12B, IL4, IFNG, HLA-B
23	atypical mycobacteriosis, familial	13.7	IFNGR1, IFNGR2, STAT1
24	natural killer cell leukemia	13.7	BCL2, BCL2L1, CD79A, IFNG
25	coccidioidomycosis	13.7	CD4, IL10, IL12A, IFNG, IFNGR1, TLR4
26	bcg infection	13.7	IL4, IKBKG, IFNG, IFNGR1, TNF, ADA
27	lymphopenia	13.7	CIITA, CD4, IL10, IL4, ANXA5, IFNG
28	african tick-bite fever	13.6	CD40LG, IL10, CCL3, IFNG
29	lepromatous leprosy	13.6	IL10, IL4, IFNG, TLR2
30	pleural tuberculosis	13.6	IL4, IFNG, TNF, ADA
31	primary immunodeficiency disease	13.6	CIITA, CD4, CD40LG, CD40, IL4, IGHV4-39
32	chronic granulomatous disease	13.6	CD79A, CD40LG, IFNG, IDO1, TNF, CYCS
33	acute chest syndrome	13.5	HLA-DQB1, HLA-DRB1, PLA2G10, PLA2G1B, PLA2G2A, G6PD
34	posterior uveitis	13.5	SAG, CD79A, CD40LG, IFNG, TNF
35	syphilis	13.5	CD79A, CD4, CD40LG, ANXA5, CCR5, IGHV4-39
36	hypergammaglobulinemia	13.5	CD79A, CD4, CD40LG, CD40, IL10, HLA-DRB1
37	opportunistic bacterial infectious disease	13.5	CD4, CD9, CCR5, IFNG, IDO1, TNF
38	hyper-ige syndrome	13.5	CD79A, IRAK4, IFNG, TYK2, STAT3
39	vogt-koyanagi-harada disease	13.5	IL17A, IFNG, HLA-B, HLA-DOA, HLA-DQB1, HLA-DRB1
40	autoimmune hemolytic anemia	13.5	CD79A, CD40LG, IL10, IL17A, IL4, IFNG
41	poliomyelitis	13.4	CD40LG, IL10, IL4, IGHV4-39, IFNG, TNF
42	cutaneous leishmaniasis	13.4	IL10, IL4, IFNG, G6PD
43	cylindromatosis	13.4	CD79A, MAPK8, MAP3K7, IKBKG, TRAF6, TLR2
44	pityriasis rosea	13.4	HLA-B, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
45	primary systemic mycosis	13.4	CD79A, IL10, IL4, IGHV4-39, TNF
46	malt lymphoma	13.4	BIRC2, BIRC3, BCL2, CD79A, CD40, IRAK1
47	interleukin receptor	13.4	IRAK1, IRAK4, IL10, IL1B, IL4
48	ullrich congenital muscular dystrophy	13.4	LAMA1, LAMA2, LAMA3, LAMA5, LAMB1, LAMB2
49	t cell deficiency	13.4	BCL2, LAT, CD79A, CD4, IL4, ANXA5
50	omenn syndrome	13.4	IL10, IL4, IFNG, IFNGR1, TNF, ADA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 clindamycin, clindamycin hydrochloride, clindamycin palmitate hydrochloride, clindamycin phosphate, clindamycin phosphate pwdr [va product], sulfadiazine, sulfamethoxazole, trimethoprim, trimethoprim sulfate

MalaCards organs/tissues related to toxoplasmosis:

²²

MGI Mouse Phenotypes related to toxoplasmosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	ADA, ADK, TAB1, COL2A1, PLA2G4A, IL12B
2	endocrine/exocrine gland phenotype	MP:0005379	10.1	LDLR, LAMA2, LAMC1, TLR2, CASP8, HSPA2
3	liver/biliary system phenotype	MP:0005370	10.1	ADA, ADK, TAB2, TLR4, MAP3K7, IL10RB
4	craniofacial phenotype	MP:0005382	9.9	MAP3K7, MAPK9, CASP9, TRAF6, COL2A1, MAPK8
5	renal/urinary system phenotype	MP:0005367	9.6	IFNGR1, CASP3, TRAF6, PLA2G4A, COL2A1, TGFB2
6	embryogenesis phenotype	MP:0005380	9.2	CASP9, TNFRSF1A, CYCS, PLA2G3, COL2A1, G6PD
7	limbs/digits/tail phenotype	MP:0005371	9.1	TRAF6, TNFRSF1A, COL2A1, TLR4, TGFB2, TGFB3
8	hematopoietic system phenotype	MP:0005397	9.1	TRAF6, MAPK9, MAP2K6, MAP3K7, IL17A, IL12B
9	other phenotype	MP:0005395	8.9	ITGB1, TNFRSF1A, PLA2G4A, NOS2, TLR2, STAT3
10	integument phenotype	MP:0010771	8.7	GNAO1, LAMB3, LAMA3, LDLR, CHUK, BCL2L1
11	skeleton phenotype	MP:0005390	7.9	ADA, STAT1, STAT3, TAB1, TGFB3, TGFB2
12	immune system phenotype	MP:0005387	7.6	NFKBIB, CASP9, CASP8, HSPA1B, GNAI3, GNAI2
13	digestive/alimentary phenotype	MP:0005381	7.5	LAMB3, LAMA5, LAMA3, BCL2, SOCS1, STAT1
14	normal phenotype	MP:0002873	7.3	AKT3, AKT2, AKT1, F2, IFNG, IKBKG
15	adipose tissue phenotype	MP:0005375	6.4	TNF, TNFRSF1A, PLA2G1B, NOS2, TLR2, TLR4
16	vision/eye phenotype	MP:0005391	6.1	COL2A1, NOS2, TNFRSF1A, TNF, TRAF6, CASP3
17	mortality/aging	MP:0010768	6.0	TAB2, TAB1, TGFB3, TGFB2, TLR4, TLR2
18	reproductive system phenotype	MP:0005389	6.0	AKT2, ITGB1, LAMC1, LAMA2, LAMA1, BAD
19	nervous system phenotype	MP:0003631	5.7	COL2A1, PLA2G6, PLA2G4A, PPIF, CYCS, TNFRSF1A
20	growth/size phenotype	MP:0005378	5.3	COL2A1, PLA2G6, PLA2G4A, PLA2G1B, CYCS, TRAF6
21	tumorigenesis	MP:0002006	4.6	SOCS1, AKT1, GNAI2, IFNGR1, IFNG, IKBKG
22	muscle phenotype	MP:0005369	4.6	MAPK12, BIRC2, RELA, PIK3CG, PIK3R1, PIK3R2
23	behavior/neurological phenotype	MP:0005386	4.0	TNF, HLA-DQB1, AKT3, AKT1, CASP3, GNAO1
24	homeostasis/metabolism phenotype	MP:0005376	3.4	TYK2, G6PD, ABCA4, RHD, NFKBIB, NFKBIA
25	cellular phenotype	MP:0005384	2.7	PIK3CD, PIK3CB, IKBKB, IL4, IL12B, IL10RB
26	cardiovascular system phenotype	MP:0005385	2.5	MAPK3, LAMA4, LAMA1, LDLR, CHUK, BCL2

Articles related to toxoplasmosis:

(show all 38)

id	Title	Authors	Year	Affiliating Genes
1	Evidence for associations between the purinergic rece ptor P2X(7) (P2RX7) and toxoplasmosis. (20535134)	Jamieson S.E.... Blackwell J.M.	2010	P2RX7
2	High diagnostic efficiency of IgM-ELISA with the use of multiple antigen peptides (MAP1) from T. gondii ESA (SAG-1, GRA-1 and GRA-7) , in acute toxoplasmosis. (20464125)	AraA_jo P.R.... Ferreira A.W.	2010	CD40LG
3	The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors. (20608477)	Flegr J.... GasovA! Z.	2010	RHD
4	Patient with toxoplasmosis and glucose-6-phosphate de hydrogenase deficiency: a case report. (19918404)	Nunes A.A.	2009	G6PD
5	Host genetic and epigenetic factors in toxoplasmosis. (19430638)	Jamieson S.E.... Blackwell J.M.	2009	COL2A1, ABCA4
6	Toxoplasmosis in pregnancy: determination of IgM, IgG and avidity in filter paper-embedded blood. (19554010)	CaA+edo-Solares I.... Correa D.	2009	CD40LG
7	The IFN-gamma +874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility. (19547871)	Albuquerque M.C.... Amendoeira M.R.	2009	IFNG
8	Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. (18523590)	Jamieson S.E.... Blackwell J.M.	2008	COL2A1, ABCA4
9	Antibodies to anionic phospholipids and cofactors in kala-azar. Comparative study with malaria, toxoplasmosis and 'autoimmune diseases'. (19032825)	Skouri H.... Ben Said M.	2008	F2, ANXA5
10	Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. (18752708)	Novotna M.... Flegr J.	2008	RHD
11	Seroprevalence of toxoplasmosis in pregnant women in Rabat, Morocco (17982862)	El Mansouri B.... Lyagoubi M.	2007	CD40LG
12	Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches. (17303977)	Prandota J.	2007	IL4, IFNG, IDO1
13	Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth. (17362565)	Gilbert R.E.... Petersen E.	2007	CD40LG
14	Some molecular aspects in schistosomiasis mansoni and toxoplasmosis. (16333889)	El-Shazly A.M.... Morsy T.A.	2005	IL4
15	Fast dipstick dye immunoassay for detection of immunoglobulin G (IgG) and IgM antibodies of human toxoplasmosis. (15643007)	Jin S.... Hong G.X.	2005	CD40LG
16	Use of recombinant antigens for early postnatal diagn osis of congenital toxoplasmosis. (16333076)	Buffolano W.... Gargano N.	2005	CD40LG
17	Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1 beta on the secretion of GnRH. (14990538)	Oktenli C.... Inal A.	2004	IL1B, CCL3
18	Prospective study of pregnants and babies with risk of congenital toxoplasmosis in municipal district of Rio Grande do Sul (12937726)	Spalding S.M.... Camillo-Coura L.	2003	CD40LG
19	The significance of complement fixation test in clinical diagnosis of toxoplasmosis. (14594352)	Ondriska F.... Vozarova G.	2003	CD40LG, CD79A
20	Toxoplasmosis in pregnant Sudanese women. (12939674)	Elnahas A.... Adam I.	2003	CD40LG
21	Immunoglobulin M (IgM)-glycoinositolphospholipid enzyme-linked immunosorbent assay: an immunoenzymatic assay for discrimination between patients with acute toxoplasmosis and those with persistent parasite-specific IgM antibodies. (11923364)	Giraldo M.... Gazzinelli R.T.	2002	CD40LG
22	The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. (12023770)	Aspinall T.V.... Sims P.F.	2002	DHPS
23	Toxoplasmosis in a group of glucose-6-phosphate dehydrogenase deficient patients. (11331490)	Tabbara K.F.... al-Momen A.K.	2001	G6PD
24	Fractionation of membrane components from tachyzoite forms of Toxoplasma gondii: differential recognition by immunoglobulin M (IgM) and IgG present in sera from patients with acute or chronic toxoplasmosis. (10747125)	Giraldo M.... Gazzinelli R.T.	2000	CD40LG
25	Comparative immunoglobulin G antibody profiles between mother and child (CGMC test) for early diagnosis of congenital toxoplasmosis. (11015373)	Gross U.... Enders G.	2000	CD40LG, CD79A
26	Three children with congenital toxoplasmosis: early report from a Swedish prospective screening study. (10419255)	Malm G.... EvengAYrd B.	1999	CD40LG
27	IgM and IgA antibody responses in 12 cases of human acquired toxoplasmosis. (9674283)	Takahashi E.E.... Rossi C.L.	1997	CD40LG, CD79A
28	Diagnosis of toxoplasmosis by joint detection of immunoglobulin A and immunoglobulin M. (9163460)	Arcavi M.... Griemberg G.	1997	CD40LG, CD79A
29	Early neonatal diagnosis of congenital toxoplasmosis: value of comparative enzyme-linked immunofiltration assay immunological profiles and anti-Toxoplasma gondii immunoglobulin M (IgM) or IgA immunocapture and implications for postnatal therapeutic strategies. (8904418)	Pinon J.M.... Bonhomme A.	1996	CD40LG, CD79A
30	Diagnosis of acquired toxoplasmosis using simultaneous determination of specific immunoglobulins M, A and E (7489131)	Valkoun A.... Kodym P.	1995	CD40LG
31	Comparative study of the serologic response of IgA a nd IgM type in the diagnosis of acute toxoplasmosis (7865558)	Lafarga B.... Elcuaz R.	1994	CD79A
32	Comparison of the diagnostic usefulness of immunoglobulins A and M in acute toxoplasmosis (8159880)	GutiAcrrez J.... Maroto M.C.	1993	CD40LG, CD79A
33	Immunoglobulin-A detection and the investigation of clinical toxoplasmosis. (8474118)	Patel B.... Holliman R.E.	1993	CD79A
34	Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS. (8501335)	Masur H.... Lundgren B.	1993	DHFR
35	No interference of rheumatoid factor(s) with toxoplasmosis IgM determination in infancy. (1728544)	DjurkoviA8-DjakoviA8 O.... SibaliA8 D.	1992	CD40LG
36	Adenosine deaminase in cerebrospinal fluid of cerebral toxoplasmosis in AIDS. (2013501)	Pedro-Botet J.... RubiAcs-Prat J.	1991	ADA
37	Platelia-Toxo IgA, a new kit for early diagnosis of congenital toxoplasmosis by detection of anti-P30 immunoglobulin A antibodies. (1939586)	Decoster A.... Duhamel M.	1991	CD79A
38	Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors (2353761)	Boudes P.... Sobel A.	1990	DHFR

Genes related to toxoplasmosis according to GeneCards:

(show top 50)    (show all 170)

id	Symbol	Description	Score	GeneCards Section Context
1	CD40LG	CD40 ligand	11.0	Pathways & Interactions, Publications
2	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
3	DHFR	dihydrofolate reductase	11.0	Publications
4	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
5	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
6	TOX4	TOX high mobility group box family member 4	11.0
7	COL2A1	collagen, type II, alpha 1	11.0	Publications
8	CNST	consortin, connexin sorting protein	11.0
9	ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	11.0	Publications
10	ADA	adenosine deaminase	11.0	Publications
11	IL17A	interleukin 17A	11.0
12	IL4	interleukin 4	11.0	Publications
13	CD4	CD4 molecule	11.0
14	ADK	adenosine kinase	11.0
15	IFNG	interferon, gamma	11.0	Pathways & Interactions, Publications
16	CENPV	centromere protein V	10.9
17	JMJD7-PLA2G4B	JMJD7-PLA2G4B readthrough	10.9	Pathways & Interactions
18	PLA2G2F	phospholipase A2, group IIF	10.9	Pathways & Interactions
19	PLA2G12B	phospholipase A2, group XIIB	10.9	Pathways & Interactions
20	PLA2G2C	phospholipase A2, group IIC	10.9	Pathways & Interactions
21	PLA2G2E	phospholipase A2, group IIE	10.9	Pathways & Interactions
22	PLA2G3	phospholipase A2, group III	10.9	Pathways & Interactions
23	PLA2G4B	phospholipase A2, group IVB (cytosolic)	10.9	Pathways & Interactions
24	IRGM	immunity-related GTPase family, M	10.9	Pathways & Interactions
25	HLA-DOB	major histocompatibility complex, class II, DO beta	10.9	Pathways & Interactions
26	PLA2G12A	phospholipase A2, group XIIA	10.9	Pathways & Interactions
27	HLA-DOA	major histocompatibility complex, class II, DO alpha	10.9	Pathways & Interactions
28	PPIF	peptidylprolyl isomerase F	10.9	Pathways & Interactions
29	HSPA2	heat shock 70kDa protein 2	10.9	Pathways & Interactions
30	NDUFB9	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa	10.9
31	BAG5	BCL2-associated athanogene 5	10.9
32	HSPA1L	heat shock 70kDa protein 1-like	10.9	Pathways & Interactions
33	OR2G2	olfactory receptor, family 2, subfamily G, member 2	10.9	Disorders
34	PLA2G5	phospholipase A2, group V	10.9	Pathways & Interactions
35	HLA-DMA	major histocompatibility complex, class II, DM alpha	10.9	Pathways & Interactions
36	HLA-DMB	major histocompatibility complex, class II, DM beta	10.9	Pathways & Interactions
37	LAMB2	laminin, beta 2 (laminin S)	10.9	Pathways & Interactions
38	PROK1	prokineticin 1	10.9
39	HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	10.9	Pathways & Interactions
40	MYL4	myosin, light chain 4, alkali; atrial, embryonic	10.9
41	PLA2G10	phospholipase A2, group X	10.9	Pathways & Interactions
42	PLA2G2D	phospholipase A2, group IID	10.9	Pathways & Interactions
43	PLA2G1B	phospholipase A2, group IB (pancreas)	10.9	Pathways & Interactions
44	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	10.9	Pathways & Interactions
45	PLA2G4E	phospholipase A2, group IVE	10.9	Pathways & Interactions
46	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	10.9	Pathways & Interactions
47	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	10.9	Pathways & Interactions
48	PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	10.9	Pathways & Interactions
49	PDK1	pyruvate dehydrogenase kinase, isozyme 1	10.9	Pathways & Interactions
50	LY96	lymphocyte antigen 96	10.9	Pathways & Interactions

Pathways related to toxoplasmosis according to GeneDecks:

(show top 50)    (show all 586)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.9	PIK3CD, PIK3R2, MAPK9
2	Development_Alpha-2 adrenergic receptor activation of ERK41	10.7	PIK3R3, GNAI1, GNAI2, GNAI3, GNAO1, PLA2G4A
3	Translation Regulation activity of EIF4F10	10.7	PIK3CB, PIK3CD, PIK3R3, PIK3R2, MAP2K3, MAPK12
4	Signal transduction_PTEN pathway41	10.7	ITGB1, CASP9
5	Immune response_NFAT in immune response41	10.6	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, LAT
6	ECM-receptor interaction20	10.1	LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1
7	Fc epsilon RI signaling pathway20	10.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway41	10.1	RELA, BIRC2, BIRC3, CHUK, XIAP, IKBKB
9	Development Dopamine D2 receptor transactivation of EGFR10	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, MAPK1
10	Immune response IL-9 signaling pathway10	9.9	PIK3CB, PIK3CD, PIK3R3, PIK3R2, RELA, JAK1
11	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	9.8	PIK3CB, PIK3CD, PIK3R2, PIK3R1, BAD, MAPK3
12	Development Leptin signaling via PI3K-dependent pathway10	9.7	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, CHUK
13	Fc-EpsilonRI Pathway36	9.5	PIK3R3, PIK3R2, PIK3R1, LAT, MAPK8, MAPK12
14	Development_Dopamine D2 receptor transactivation of EGFR41	9.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
15	Development Thrombopoietin-regulated cell processes10	9.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
16	Development_FGF-family signaling41	9.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
17	Cell adhesion_PLAU signaling41	9.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
18	G-protein signaling_G-Protein alpha-12 signaling pathway41	9.2	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, MAPK8
19	IL-7 Signaling Pathways37	9.2	PIK3CB, PIK3CD, PIK3R1, PIK3CG, BAD, JAK1
20	Signal transduction_AKT signaling41	9.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
21	CNTF Signaling36	9.2	PIK3R3, PIK3R2, PIK3R1, JAK1, JAK2, MAP2K6
22	Development_A2B receptor- action via G-protein alpha s41	9.2	PIK3CB, PIK3CD, PIK3CA, RELA, MAP2K3, MAPK12
23	CMV and MAPK Pathways36	9.1	PIK3R3, PIK3R2, PIK3R1, CHUK, MAP2K6, MAP2K3
24	Immune response IL-23 signaling pathway10	9.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25	Development_A3 receptor signaling41	9.1	PIK3R5, PIK3CG, RELA, CHUK, MAPK3, IKBKB
26	LPS Stimulated MAPK Signaling36	9.0	PIK3R3, PIK3R2, PIK3R1, CHUK, MAPK8, MAP3K7
27	UVB-Induced MAPK Signaling36	8.9	PIK3R3, PIK3R2, PIK3R1, BAD, MAPK8, MAPK12
28	Development PDGF signaling via STATs and NF-kB10	8.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
29	B cell receptor signaling pathway20	8.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
30	TNFR2 Pathway36	8.8	BIRC2, BIRC3, CHUK, MAPK8, MAP3K7, MAPK10
31	Immune response CD28 signaling10	8.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
32	NF-kappaB Signaling3	8.6	RELA, MYD88, CHUK, IRAK1, IRAK4, IL1B
33	LT-BetaR Pathway36	8.5	PIK3R3, PIK3R2, PIK3R1, RELA, BIRC2, CHUK
34	Systemic lupus erythematosus20	8.5	CD40LG, CD40, IL10, IFNG, HLA-DMA, HLA-DMB
35	Allograft rejection20	8.4	CD40LG, CD40, IL10, IL12A, IL12B, IL4
36	Neurotrophin signaling pathway20	7.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
37	T cell receptor signaling pathway20	7.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
38	Measles20	7.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
39	TNF-Induced Apoptosis Implicating Sphingolipids36	7.7	BAD, MAPK8, MAP2K6, MAP2K3, MAPK12, MAPK13
40	Immune response_MIF in innate immunity response41	7.7	RELA, MYD88, CHUK, IRAK1, IRAK4, IL1B
41	Immune response_IL-1 signaling pathway41	7.5	RELA, MYD88, CHUK, IRAK1, IRAK4, IL1B
42	TGF-beta Signaling Pathways37	7.4	PIK3CB, PIK3CD, PIK3R2, PIK3R1, PIK3CG, RELA
43	HMGB1 Pathway36	7.3	PIK3R3, PIK3R2, PIK3R1, IL1B, MAPK8, MAP2K6
44	STAT3 Pathway36	6.9	BCL2, JAK2, CD4, IL10, IL10RA, IL10RB
45	14-3-3 Induced Apoptosis36	6.1	PIK3R3, PIK3R2, PIK3R1, MYD88, BCL2, CHUK
46	Rho Family GTPases36	6.0	PIK3R3, PIK3R2, PIK3R1, BCL2, LAMA1, LAMA2
47	MAPK Signaling36	5.9	PIK3R3, PIK3R2, PIK3R1, BCL2, CHUK, LAMA1
48	Pathways in cancer20	5.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
49	Influenza A20	5.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
50	Tuberculosis20	3.1	RELA, MYD88, BCL2, CIITA, BAD, JAK1

Compounds related to toxoplasmosis according to GeneDecks:

(show top 50)    (show all 347)

id	Compound	Score	Top Affiliating Genes
1	rhc 8026742 32	11.7	PLA2G10, PLA2G12B, PLA2G1B, PLA2G2C, PLA2G2E, PLA2G3
2	obaa42	10.6	PLA2G10, PLA2G12B, PLA2G1B, PLA2G2C, PLA2G2E, PLA2G3
3	pacocf342	10.4	PLA2G10, PLA2G12B, PLA2G1B, PLA2G2C, PLA2G2E, PLA2G3
4	phosphatidylserine32 9 9	11.7	BCL2, BAD, P2RX7, CD79A, F2, CASP8
5	heparin32 9 18 9	12.5	PIK3CA, PIK3CG, LAMA1, LAMA2, LAMA5, LAMB2
6	sp 60012532 42	10.5	PIK3CG, BIRC2, BIRC3, CD40, IL17A, IKBKB
7	pge232	9.3	CIITA, LDLR, SAG, P2RX7, CD4, IL17A
8	rapamycin32 42	10.0	PIK3CG, LDLR, JAK2, MAPK8, MAPK10, CCR5
9	staurosporin32	8.9	PIK3CA, PIK3CG, BCL2, BCL2L1, MAPK14, MAPK10
10	neopterin32	8.9	CD79A, CD4, CD40LG, CD40, CD9, IL10
11	poly(i-c)32	8.7	CHUK, IL12B, IL1B, IL4, CCL3, IFNG
12	calcium32 9 18 9	11.7	PIK3CD, RELA, BIRC3, CIITA, BAD, LAT
13	5fluorouracil32	8.7	PIK3CA, PIK3CG, BIRC2, BIRC3, BCL2, BCL2L1
14	h2o232	8.6	PIK3CB, PIK3R1, PIK3CG, LDLR, BAD, JAK1
15	egcg32	8.6	PIK3CG, BCL2L1, CHUK, LDLR, XIAP, MAPK8
16	polyinosinic-polycytidylic acid32	8.4	CIITA, CD40, IL10, IL12B, IL4, MAPK14
17	piceatannol32 42 9 9	11.4	PIK3CG, CHUK, JAK1, JAK2, MAPK8, MAPK3
18	cysteine32	8.3	BCL2L1, CHUK, LDLR, XIAP, CD79A, CD4
19	thalidomide32 42 9 9	11.2	BIRC2, BIRC3, BCL2L1, CHUK, XIAP, CD40LG
20	glutamate32	8.2	PIK3CB, PIK3CA, PIK3R1, CHUK, LDLR, XIAP
21	bortezomib32 9 9	10.2	BCL2, BCL2L1, CHUK, XIAP, CD40LG, ANXA5
22	okadaic acid32 42	9.2	PIK3CA, PIK3R1, RELA, BCL2, BCL2L1, CHUK
23	doxorubicin32 34 9 9	11.0	PIK3CA, PIK3CG, BIRC2, BIRC3, BCL2L1, CHUK
24	phosphoinositide32	7.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25	rantes32	7.6	MYD88, CIITA, CHUK, CD4, CD40LG, CD40
26	atp32	7.6	PIK3CB, PIK3CA, PIK3R1, MYD88, BCL2L1, CHUK
27	parthenolide32	7.3	PIK3CG, BIRC3, BCL2L1, CHUK, JAK2, MAPK8
28	ns 39832 42	8.3	PIK3CG, IL17A, IL1B, MAPK8, MAPK14, MAPK1
29	nitric oxide32 9 18 9	10.2	PIK3CB, MYD88, CIITA, BAD, JAK1, JAK2
30	imatinib32 34 9 9	10.1	PIK3CA, PIK3R1, PIK3CG, BCL2, BCL2L1, XIAP
31	lipid32	7.1	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, MYD88
32	simvastatin32 34 42 9 18 9	12.1	CIITA, CHUK, LDLR, CD40, IL10, IL4
33	thapsigargin32 42	8.1	PIK3CG, BCL2, BCL2L1, IL4, ANXA5, MAPK8
34	triptolide32	7.0	BIRC3, BCL2, CD40, IL1B, ANXA5, MAPK8
35	resveratrol32 9 18 9	10.0	PIK3CA, PIK3CG, BCL2, BCL2L1, CHUK, XIAP
36	adp32 18	8.0	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BCL2L1, CHUK
37	oxygen32 18	7.8	BIRC3, BCL2, BCL2L1, CIITA, CHUK, BAD
38	etoposide32 42 9 9	9.7	PIK3CB, PIK3CA, PIK3R1, PIK3CG, BIRC2, BIRC3
39	paclitaxel32 34 9 9	9.7	PIK3CA, PIK3CG, BIRC2, BIRC3, BCL2, BCL2L1
40	alanine32	6.6	BIRC3, CIITA, CHUK, LDLR, BAD, SAG
41	cyclosporin a32 42	7.4	PIK3CA, PIK3CG, CIITA, LDLR, BAD, SAG
42	cisplatin32 34 9 9	8.9	PIK3CA, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
43	butyrate32	5.8	BCL2, BCL2L1, XIAP, JAK1, JAK2, CD40
44	15-deoxy-delta-12,14-prostaglandin j232	5.6	PIK3CG, BIRC2, BCL2L1, JAK1, JAK2, IL10
45	phosphatidylinositol32	5.5	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
46	pdtc32	5.1	PIK3CA, PIK3CG, BIRC3, BCL2, BCL2L1, CHUK
47	ly29400232	4.8	PIK3CB, PIK3CA, PIK3R1, PIK3CG, BIRC2, BIRC3
48	curcumin32	4.1	PIK3CG, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
49	retinoic acid32 42 18	5.4	PIK3CA, PIK3CG, BCL2, BCL2L1, CHUK, LDLR
50	dexamethasone32 42 34 9 9	7.3	PIK3CA, PIK3R1, BIRC2, BIRC3, BCL2, BCL2L1

Cellular components related to toxoplasmosis according to GeneDecks:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	laminin-11 complex	GO:043260	10.5	LAMC1, LAMB2, LAMA5
2	CD40 receptor complex	GO:035631	10.4	TRAF6, IKBKB, CD40, CHUK, BIRC2
3	IkappaB kinase complex	GO:008385	10.4	IKBKG, IKBKB, MAP3K7, CHUK
4	laminin-1 complex	GO:005606	10.4	LAMC1, LAMB1, LAMA5, LAMA4, LAMA3, LAMA2
5	laminin-10 complex	GO:043259	10.3	LAMC1, LAMB1, LAMA5
6	basement membrane	GO:005604	10.3	LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1
7	endosome membrane	GO:010008	10.3	HLA-DQA2, HLA-DQB1, TRAF6, TLR4, TAB1, TAB2
8	extracellular matrix	GO:031012	10.2	TGFB3, TGFB2, LAMC1, LAMB2, LAMB1, LAMA5
9	late endosome membrane	GO:031902	10.1	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DMB
10	MHC class II protein complex	GO:042613	10.1	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA, HLA-DQB1
11	laminin-5 complex	GO:005610	10.1	LAMC2, LAMB3, LAMA3
12	lysosomal membrane	GO:005765	10.1	HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, PLA2G4E
13	trans-Golgi network membrane	GO:032588	10.0	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA, HLA-DQB1
14	transport vesicle membrane	GO:030658	9.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
15	endocytic vesicle membrane	GO:030666	9.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
16	clathrin-coated endocytic vesicle membrane	GO:030669	9.8	LDLR, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1
17	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.7	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
18	ER to Golgi transport vesicle membrane	GO:012507	9.6	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
19	membrane raft	GO:045121	9.5	GNAI3, CASP8, TNF, TNFRSF1A, TLR4, GNAI2
20	external side of plasma membrane	GO:009897	9.0	IFNG, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, TNF
21	extracellular region	GO:005576	8.6	PLA2G12A, PLA2G4B, PLA2G3, PLA2G2E, PLA2G2C, PLA2G1B
22	cell surface	GO:009986	8.6	ADA, TGFB3, TGFB2, TGFB1, TLR2, PLA2G5
23	integral to plasma membrane	GO:005887	8.2	HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, TNF, TNFRSF1A
24	extracellular space	GO:005615	7.8	PLA2G3, PLA2G1B, TNFRSF1A, TNF, F2, PLA2G2A
25	plasma membrane	GO:005886	6.1	HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DQA2
26	cytosol	GO:005829	4.8	PSMC2, SOCS1, ADK, ADA, MYL4, PIK3CB

Biological processes related to toxoplasmosis according to GeneDecks:

(show top 50)    (show all 121)

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylglycerol acyl-chain remodeling	GO:036148	11.1	PLA2G3, PLA2G2E, PLA2G1B, PLA2G10, PLA2G5, PLA2G2F
2	phosphatidylserine acyl-chain remodeling	GO:036150	11.0	PLA2G5, PLA2G4E, PLA2G2F, PLA2G2D, PLA2G2A, PLA2G12A
3	phosphatidylethanolamine acyl-chain remodeling	GO:036152	11.0	PLA2G6, PLA2G4B, PLA2G4A, PLA2G3, PLA2G2E, PLA2G1B
4	phosphatidylcholine acyl-chain remodeling	GO:036151	11.0	PLA2G6, PLA2G4B, PLA2G4A, PLA2G3, PLA2G2E, PLA2G1B
5	phosphatidylinositol acyl-chain remodeling	GO:036149	11.0	PLA2G4A, PLA2G2E, PLA2G1B, PLA2G10, PLA2G12A, PLA2G2A
6	glycerophospholipid biosynthetic process	GO:046474	10.9	PLA2G5, AGPAT9, PLA2G10, PLA2G1B, PLA2G2E, PLA2G3
7	phosphatidic acid biosynthetic process	GO:006654	10.9	PLA2G2A, PLA2G12A, PLA2G4B, PLA2G4A, PLA2G2E, PLA2G1B
8	lipid catabolic process	GO:016042	10.8	PLA2G2E, PLA2G6, PLA2G3, PLA2G2A, PLA2G2F, PLA2G2C
9	phospholipid metabolic process	GO:006644	10.5	PLA2G2C, PLA2G1B, PLA2G10, PIK3CG, PIK3R5, PIK3R1
10	nucleotide-binding oligomerization domain containing signaling pathway	GO:070423	10.3	IRAK1, CHUK, MAP3K7, MAP2K6, IKBKB, IKBKG
11	I-kappaB kinase/NF-kappaB cascade	GO:007249	10.3	LY96, TRAF6, IKBKG, TLR4, IKBKB, MAP3K7
12	regulation of interferon-gamma-mediated signaling pathway	GO:060334	10.2	IFNG, IFNGR2, JAK1, JAK2, STAT1, SOCS1
13	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	10.1	HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRB5, TRAF6, HLA-DRA
14	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.0	P2RX7, CHUK, BCL2L1, BCL2, IRAK1, MAP3K7
15	positive regulation of MHC class II biosynthetic process	GO:045348	10.0	IL10, CIITA, TLR4, IFNG, IL4, CD40LG
16	T-helper 1 type immune response	GO:042088	10.0	IL12B, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, TRAF6
17	cell surface receptor signaling pathway	GO:007166	9.9	BIRC2, CD4, P2RX7, SAG, LAMA1, CCR5
18	positive regulation of type I interferon production	GO:032481	9.9	RELA, NFKBIB, CHUK, IKBKG, NFKB1, NFKBIA
19	positive regulation of tumor necrosis factor production	GO:032760	9.8	MYD88, TLR4, TLR2, TNFRSF1A, IFNG, CCL3
20	JNK cascade	GO:007254	9.6	TAB1, IRAK1, MAP3K7, TAB2, TNF, MYD88
21	stress-activated MAPK cascade	GO:051403	9.5	TAB2, TAB1, TRAF6, IKBKG, MAPK9, MAPK1
22	immune response	GO:006955	9.5	HLA-DRB3, CCR5, IL4, IL17A, IL12A, IL10RB
23	T cell costimulation	GO:031295	9.4	HLA-DRA, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-DPB1, HLA-DPA1
24	interferon-gamma-mediated signaling pathway	GO:060333	9.4	SOCS1, IFNGR2, IFNGR1, IFNG, JAK2, JAK1
25	T cell receptor signaling pathway	GO:050852	9.1	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-DPB1
26	MyD88-independent toll-like receptor signaling pathway	GO:002756	8.9	TAB2, MAPK3, MAP2K3, MAP2K6, MAP3K7, MAPK8
27	toll-like receptor 3 signaling pathway	GO:034138	8.9	LY96, TAB2, TAB1, TLR4, NFKBIB, NFKBIA
28	TRIF-dependent toll-like receptor signaling pathway	GO:035666	8.9	LY96, TAB2, TAB1, TLR4, NFKBIB, NFKBIA
29	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	8.8	CASP8, TRAF6, TNF, TNFRSF1A, TLR4, TAB2
30	toll-like receptor 4 signaling pathway	GO:034142	8.8	IKBKG, IRAK1, CHUK, MYD88, RELA, IRAK4
31	toll-like receptor 2 signaling pathway	GO:034134	8.8	LY96, TAB2, TAB1, TLR4, TLR2, NFKBIB
32	toll-like receptor 1 signaling pathway	GO:034130	8.7	LY96, TAB2, TAB1, TLR4, TLR2, NFKBIB
33	cellular response to mechanical stimulus	GO:071260	8.7	NFKB1, BAD, TLR4, MYD88, TNFRSF1A, CASP8
34	induction of apoptosis by intracellular signals	GO:008629	8.7	BCL2, BCL2L1, BAD, XIAP, MAPK8, CASP3
35	toll-like receptor signaling pathway	GO:002224	8.7	LY96, MAPK10, MAPK14, MAPK3, MAP2K3, MAP2K6
36	MyD88-dependent toll-like receptor signaling pathway	GO:002755	8.7	RELA, LY96, TAB2, TAB1, MAPK14, MAPK3
37	Toll signaling pathway	GO:008063	8.7	RELA, MAP2K3, MAPK3, MAPK14, MAPK10, MAPK11
38	activation of MAPK activity	GO:000187	8.4	MAPK10, MAPK14, MAPK3, MAP2K3, MAP2K6, MAP3K7
39	cytokine-mediated signaling pathway	GO:019221	8.1	SOCS1, HLA-DRA, HLA-DQB1, STAT1, HLA-DRB1, STAT3
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.0	IL1B, IRAK1, CD40, CHUK, MYD88, RELA
41	innate immune response	GO:045087	8.0	NFKBIA, NFKB1, TRAF6, CASP8, IKBKG, IKBKB
42	lipopolysaccharide-mediated signaling pathway	GO:031663	7.9	TLR2, NFKBIA, TNF, CCL3, MAPK14, MAPK3
43	nerve growth factor receptor signaling pathway	GO:048011	7.9	CASP3, IKBKB, MAPK1, MAPK11, MAPK14, MAPK3
44	platelet activation	GO:030168	7.9	CD9, CD40, CD40LG, LAT, PIK3CG, PIK3R5
45	anti-apoptosis	GO:006916	7.7	IRAK1, CD40LG, XIAP, BAG1, BCL2L1, BCL2
46	blood coagulation	GO:007596	7.1	GNAI2, TGFB3, TGFB2, TGFB1, PIK3CG, PIK3CB
47	virus-host interaction	GO:019048	7.1	IKBKG, CCR5, HLA-B, TNFRSF1A, NFKBIA, TGFB1
48	inflammatory response	GO:006954	7.1	RELA, PIK3CG, PIK3CD, MYD88, LY96, TGFB1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	TRAF6, AKT1, RELA, MYD88, CIITA, TNFRSF1A
50	apoptotic process	GO:006915	6.2	MAPK8, BIRC3, BCL2, BCL2L1, BAD, BAG1

Molecular functions related to toxoplasmosis according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium-dependent phospholipase A2 activity	GO:047498	10.8	PLA2G5, PLA2G2A, PLA2G12A, PLA2G4B, PLA2G4A, PLA2G3
2	phospholipase A2 activity	GO:004623	10.8	PLA2G2A, PLA2G2D, PLA2G2F, PLA2G4E, PLA2G6, PLA2G4A
3	1-phosphatidylinositol-3-kinase activity	GO:016303	10.4	PIK3CG, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB
4	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:046934	10.3	PIK3CG, PIK3CA, PIK3CD, PIK3CB
5	phosphatidylinositol 3-kinase activity	GO:035004	10.3	PIK3CG, PIK3CA, PIK3CD, PIK3CB
6	MHC class II receptor activity	GO:032395	10.1	HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQA2, HLA-DQB1
7	MAP kinase activity	GO:004707	10.1	MAPK1, MAPK11, MAPK14, MAPK3, MAPK13, MAPK12
8	MAP kinase kinase activity	GO:004708	10.0	MAPK10, MAPK14, MAP2K3, MAP2K6, MAP3K7
9	calcium ion binding	GO:005509	10.0	PLA2G12A, PLA2G2A, PLA2G2D, PLA2G2F, PLA2G5, STAT3
10	JUN kinase activity	GO:004705	9.9	MAPK8, MAPK10, MAPK9
11	protein kinase binding	GO:019901	9.8	MAP2K3, IKBKB, TRAF6, STAT3, SOCS1, MAP2K6
12	protein kinase activity	GO:004672	9.2	PDK1, AKT3, AKT1, IKBKB, CCL3, MAP3K7
13	protein serine/threonine kinase activity	GO:004674	9.0	MAPK14, MAPK11, MAPK1, IKBKB, AKT1, AKT2
14	cytokine activity	GO:005125	8.9	TGFB2, TNF, IFNG, IL4, IL1B, IL17A
15	protein heterodimerization activity	GO:046982	8.8	IKBKB, TLR2, TGFB1, TGFB2, TGFB3, IL12B
16	receptor binding	GO:005102	8.7	HSPA8, HLA-B, PLA2G1B, NOS2, TGFB2, F2
17	growth factor activity	GO:008083	8.4	PROK1, TGFB3, TGFB2, TGFB1, F2, IL4
18	ATP binding	GO:005524	8.1	HSPA1L, HSPA1B, HSPA2, IKBKB, MAPK9, MAPK1
19	protein binding	GO:005515	2.7	IKBKB, AKT3, HLA-DRB3, HLA-DRB4, TRAF6, TNF