MCID: TXP001
MIFTS: 65

Toxoplasmosis

Categories: Infectious diseases, Rare diseases, Fetal diseases, Neuronal diseases

Aliases & Classifications for Toxoplasmosis

MalaCards integrated aliases for Toxoplasmosis:

Name: Toxoplasmosis 12 72 51 40 3 41 14 69
Multisystemic Disseminated Toxoplasmosis 69
Disseminated Toxoplasmosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9965
ICD10 32 B58 B58.9 B58.8
ICD9CM 34 130 130.9
MeSH 41 D014123
NCIt 46 C3418

Summaries for Toxoplasmosis

MedlinePlus : 40 Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii. More than 60 million people in the U.S. have the parasite. Most of them don't get sick. But the parasite causes serious problems for some people. These include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. Problems can include damage to the brain, eyes, and other organs. You can get toxoplasmosis from Waste from an infected cat Eating contaminated meat that is raw or not well cooked Using utensils or cutting boards after they've had contact with contaminated raw meat Drinking infected water Receiving an infected organ transplant or blood transfusion Most people with toxoplasmosis don't need treatment. There are drugs to treat it for pregnant women and people with weak immune systems. Centers for Disease Control and Prevention

MalaCards based summary : Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and ocular toxoplasmosis, and has symptoms including pruritus and fever. An important gene associated with Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfadiazine and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A coccidiosis that has material basis in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC : 3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 30 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia : 72 Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with toxoplasmosis usually... more...

Related Diseases for Toxoplasmosis

Diseases in the Toxoplasmosis family:

Congenital Toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 544)
# Related Disease Score Top Affiliating Genes
1 congenital toxoplasmosis 34.4 CD40LG CD79A HLA-DQA1 HLA-DQB1
2 ocular toxoplasmosis 33.7 CD40LG CD79A TLR9
3 rubella 30.2 CD40LG IL10 IL4 TNF
4 uveitis 30.1 IFNG IL10 IL4 TNF
5 alpha chain disease 30.1 CD40LG CD79A
6 listeriosis 30.0 IL10 IL6 TNF
7 cryptosporidiosis 30.0 CD40LG CD79A DHFR
8 pneumocystosis 29.9 CD40LG CD79A DHFR TNF
9 granulomatous hepatitis 29.8 CD40LG CD79A IL4
10 cytomegalovirus infection 29.7 IFNG IL10 IL6 TNF
11 campylobacteriosis 29.7 IFNG IL1B TLR4
12 candidiasis 29.7 CD79A IFNG IL10
13 neuritis 29.6 IFNG IL1B IL4 TNF
14 myasthenia gravis 29.5 IFNG IL10 IL4 TNF
15 combined immunodeficiency, x-linked 29.5 CD40 CD40LG CD79A IL4
16 hematopoietic stem cell transplantation 29.5 IFNG IL10 IL6 TNF
17 post-transplant lymphoproliferative disease 29.4 IL10 IL6 TNF
18 adult respiratory distress syndrome 29.4 IL10 IL6 TNF
19 schistosomiasis 29.4 CD40LG CD79A IFNG IL10 IL4 TNF
20 cysticercosis 29.3 IL1B IL6 TLR4
21 leptospirosis 29.3 CD40LG IL10 IL1B IL6 TNF
22 lyme disease 29.3 CD40LG IL1B IL6 TNF
23 lymphadenitis 29.3 IFNG IL10 IL1B TLR4 TNF
24 cryptococcosis 29.2 IFNG IL4 TLR9
25 allergic hypersensitivity disease 29.2 IFNG IL10 IL4 TLR9
26 aplastic anemia 29.1 IFNG IL4 IL6 TNF
27 diabetes mellitus 29.1 HLA-DQA1 HLA-DQB1 IL1B IL6 TNF
28 kawasaki disease 29.1 IL10 IL6 MYD88 TNF
29 arthritis 29.0 HLA-DQB1 IFNG IL10 IL1B IL6 TNF
30 acquired immunodeficiency syndrome 28.8 CCR5 CD40LG CD79A IFNG IL10 IL1B
31 echinococcosis 28.7 CD40LG CD79A IFNG IL10 IL6 TNF
32 meningoencephalitis 28.7 CD40LG CD79A IL6 TLR9
33 pulmonary tuberculosis 28.6 IFNG IL10 IL4 TLR9 TNF
34 brucellosis 28.6 CD40LG IFNG IL10 IL4 IL6 TLR4
35 q fever 28.5 CD40LG CD79A IFNG IL10 IL1B TLR4
36 mycobacterium tuberculosis 1 28.3 IFNG IL10 IL4 MYD88 TLR4 TLR9
37 meningitis 28.3 CD40LG IFNG IL10 IL1B IL6 TLR9
38 parasitic helminthiasis infectious disease 28.3 CD40LG CD79A IL10 IL4 TLR9 TNF
39 central nervous system vasculitis 28.1 CD40LG IFNG IL1B IL6 TLR9 TNF
40 chlamydia 28.1 CD40LG CD79A IFNG IL10 IL1B IL6
41 trypanosomiasis 28.1 IFNG IL10 IL1B IL4 IL6 TLR9
42 nervous system disease 27.8 CD40LG IFNG IL10 IL1B IL6 TLR9
43 tonsillitis 27.8 CD79A IFNG IL1B IL4 IL6 TLR9
44 pneumonia 27.8 CD40LG IL10 IL1B IL6 TLR4 TLR9
45 leishmaniasis 27.6 HLA-DQA1 IFNG IL10 IL1B IL4 TLR4
46 coccidiosis 27.4 CD40LG CD79A IFNG IL10 IL4 RHD
47 rheumatoid arthritis 27.3 CD40LG CD79A HLA-DQA1 HLA-DQB1 IFNG IL10
48 intestinal disease 27.2 CD79A IFNG IL10 IL1B IL6 TLR4
49 common variable immunodeficiency 27.1 CD40 CD40LG CD79A IFNG IL10 IL4
50 multiple sclerosis 26.6 CCR5 CD40 HLA-DQB1 IFNG IL10 IL1B

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to Toxoplasmosis

Symptoms & Phenotypes for Toxoplasmosis

UMLS symptoms related to Toxoplasmosis:


pruritus, fever

GenomeRNAi Phenotypes related to Toxoplasmosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.78 IL1B MYD88 TNF CD40LG DHFR HLA-DQB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.78 IL1B MYD88 TNF CD40LG DHFR HLA-DQB1

MGI Mouse Phenotypes related to Toxoplasmosis:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.5 IL10 IL1B IL4 IL6 MYD88 RHD
2 homeostasis/metabolism MP:0005376 10.47 CD40 CD40LG CD79A DHFR HLA-DQB1 IFNG
3 immune system MP:0005387 10.45 ALOX12 CCR5 CD40 CD40LG CD79A DHFR
4 cellular MP:0005384 10.39 CCR5 CD40LG CD79A DHFR HLA-DQB1 IFNG
5 cardiovascular system MP:0005385 10.32 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
6 mortality/aging MP:0010768 10.29 CCR5 CD40LG DHFR HLA-DQB1 IFNG IL10
7 digestive/alimentary MP:0005381 10.27 HLA-DQB1 IFNG IL10 IL4 IL6 MYD88
8 endocrine/exocrine gland MP:0005379 10.26 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
9 nervous system MP:0003631 10.22 TLR4 TNF CCR5 CD40 CD40LG CD79A
10 integument MP:0010771 10.21 TNF ALOX12 CD40LG DHFR IFNG IL10
11 liver/biliary system MP:0005370 10.19 IFNG IL10 IL4 IL6 TLR4 TNF
12 neoplasm MP:0002006 10.09 CCR5 CD79A IFNG IL10 IL1B IL6
13 muscle MP:0005369 10.06 IFNG IL10 IL6 TLR4 TNF CCR5
14 renal/urinary system MP:0005367 10.02 CD40 CD40LG CD79A HLA-DQB1 IFNG IL4
15 reproductive system MP:0005389 9.96 CCR5 CD40LG HLA-DQB1 IFNG IL10 IL4
16 no phenotypic analysis MP:0003012 9.91 CCR5 CD79A IFNG IL10 IL4 MYD88
17 respiratory system MP:0005388 9.76 HLA-DQB1 IFNG IL10 IL4 IL6 MYD88
18 skeleton MP:0005390 9.65 MYD88 TLR4 TNF CD40 CD40LG IFNG
19 vision/eye MP:0005391 9.23 CCR5 IFNG IL10 IL4 IL6 MYD88

Drugs & Therapeutics for Toxoplasmosis

Drugs for Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 68-35-9 5215
2
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 58-14-0 4993
3
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
4
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
5
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
6
Bevacizumab Approved, Investigational Phase 4 216974-75-3
7
Spiramycin Approved Phase 4,Phase 3 24916-50-5
8
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
9
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
11 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
12 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1
16 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Central Nervous System Depressants Phase 4
20 Micronutrients Phase 4,Phase 3,Phase 1
21 GABA Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 Trace Elements Phase 4,Phase 3,Phase 1
24 Tranquilizing Agents Phase 4
25 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
26 Angiogenesis Inhibitors Phase 4
27 Angiogenesis Modulating Agents Phase 4
28 Vitamins Phase 4,Phase 3,Phase 1
29 Anticonvulsants Phase 4
30 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
31 Antimanic Agents Phase 4
32 Psychotropic Drugs Phase 4
33 Bone Density Conservation Agents Phase 4,Phase 1
34 Calcium, Dietary Phase 4,Phase 2,Phase 1
35 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
36 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
37
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
38
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
39
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
40
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
41
Zidovudine Approved Phase 3,Phase 1 30516-87-1 35370
42
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
43
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
44
Azithromycin Approved Phase 3,Phase 1 83905-01-5 53477736 447043 55185
45
Dapsone Approved, Investigational Phase 3 80-08-0 2955
46
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
47
Rifabutin Approved, Investigational Phase 3 72559-06-9 6323490
48
Pentamidine Approved, Investigational Phase 3 100-33-4 4735
49 Prednisolone acetate Phase 3
50 Dexamethasone acetate Phase 3 1177-87-3

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii Infection in Early Course Schizophrenia Completed NCT02011750 Phase 4 Sodium Valproate treatment;Placebo
2 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
3 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
4 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
5 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
6 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
7 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3 Trimethoprim-Sulfamethoxazole
8 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3 Pyrimethamine/Sulfadiazine;Spiramycine
9 Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression Completed NCT00300404 Phase 3 daraprim;pyrimethamine;folinic acid
10 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
11 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
12 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3 Azithromycin;Rifabutin;Fluconazole
13 Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Completed NCT00000643 Phase 2 Pyrimethamine;Leucovorin calcium
14 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed NCT00000794 Phase 2 Sulfadiazine;Clarithromycin;Atovaquone;Pyrimethamine;Leucovorin calcium
15 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
16 Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects Completed NCT03258762 Phase 1 Pyrimethamine;Calcium folinate
17 A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Completed NCT00000973 Phase 1 Pyrimethamine;Leucovorin calcium;Zidovudine
18 Antiretroviral Drug Interaction Study in Volunteers With HIV Completed NCT01479361 Phase 1 Atovaquone 750 mg twice daily;Atovaquone 1500 mg twice daily
19 A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Completed NCT00000966 Phase 1 Azithromycin;Pyrimethamine;Leucovorin calcium
20 A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC Completed NCT00000680 Phase 1 Zidovudine;Aldesleukin
21 A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis Withdrawn NCT00679744 Phase 1 Pyrimethamine
22 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
23 Cerebral Toxoplasmosis and AIDS Completed NCT00803621
24 A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection Completed NCT00000666 Pyrimethamine
25 A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Completed NCT00001994 Atovaquone
26 A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Completed NCT00000674 Pyrimethamine;Leucovorin calcium;Clindamycin
27 Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse Completed NCT00002064 Pyrimethamine;Clindamycin
28 Drug Exposure Registry for GSK2248761, an Investigational NNRTI Completed NCT01458132 GSK2248761
29 Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma Completed NCT00226304
30 Uveitis Gene-Expression Profiling Completed NCT00874471
31 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Recruiting NCT02863588
32 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
33 Apheresis of Patients With Immunodeficiency Recruiting NCT01212055
34 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Recruiting NCT02787486
35 New Diagnostic Approach for Congenital Toxoplasmosis Not yet recruiting NCT03385499
36 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: toxoplasmosis

Genetic Tests for Toxoplasmosis

Anatomical Context for Toxoplasmosis

MalaCards organs/tissues related to Toxoplasmosis:

38
Eye, Brain, Testes, Lymph Node, T Cells, Bone, Kidney

Publications for Toxoplasmosis

Articles related to Toxoplasmosis:

(show top 50) (show all 1606)
# Title Authors Year
1
Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran. ( 29335806 )
2018
2
Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients. ( 29343531 )
2018
3
High heterogeneity, mixed infections and new genotypes in human congenital toxoplasmosis cases in the mega-metropolis of Central Mexico. ( 29170005 )
2018
4
Large macular scar secondary to congenital toxoplasmosis. ( 29290459 )
2018
5
Polymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American setting. ( 29409823 )
2018
6
A novel chemiluminescent immunoassay based on original acridinium ester labels as better solution for diagnosis of human toxoplasmosis than conventional ELISA test. ( 29398460 )
2018
7
Nanoemulsion of atovaquone as a promising approach for treatment of acute and chronic toxoplasmosis. ( 29452213 )
2018
8
Evaluation of Immune Responses Induced by<i>GRA7</i>and<i>ROP2</i>Genes by DNA Vaccine Cocktails Against Acute Toxoplasmosis in BALB/c Mice. ( 29296260 )
2018
9
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis. ( 29221851 )
2018
10
GENETIC POLYMORPHISMS IN CYTOKINE GENES IN COLOMBIAN PATIENTS WITH OCULAR TOXOPLASMOSIS. ( 29426041 )
2018
11
Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections. ( 29037967 )
2018
12
Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice. ( 29309783 )
2018
13
Cerebral Toxoplasmosis Diagnosed by Nested-Polymerase Chain Reaction in a Patient with Rheumatoid Arthritis. ( 29321415 )
2018
14
Disseminated cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia. ( 29428267 )
2018
15
Author Response: Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections: Emphasis on the Role of Neuroimaging in Screening, Prognostication, and Follow-Up. ( 29037966 )
2018
16
High rates of cerebral toxoplasmosis in HIV patients presenting with meningitis in Accra, Ghana. ( 29373741 )
2017
17
Congenital Toxoplasmosis. ( 28254246 )
2017
18
Diagnosis, Treatment, and Prevention of Congenital Toxoplasmosis in the United States. ( 28138010 )
2017
19
Fetomaternal and Pediatric Toxoplasmosis. ( 29230092 )
2017
20
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
21
High Frequency of Bone Marrow Depression During Congenital Toxoplasmosis Therapy in a Cohort of Children Identified By Neonatal Screening in Minas Gerais, Brazil. ( 28151845 )
2017
22
Diagnosis of congenital toxoplasmosis in a renal transplant recipient mother. ( 28851620 )
2017
23
Evaluation of gene expression levels for cytokines in ocular toxoplasmosis. ( 28836673 )
2017
24
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. ( 28486633 )
2017
25
The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis. ( 28838776 )
2017
26
Pitfalls of PACNS: A Rare Case of Central Nervous System Vasculitis Associated with Toxoplasmosis. ( 28765346 )
2017
27
Toxoplasmosis and Lymphoma: The Mimickers. ( 28900346 )
2017
28
Rare case of acute toxoplasmosis in a domestic rabbit (Oryctolagus cuniculus) in Brazil associated with the type BrIII Brazilian clonal lineage of Toxoplasma gondii. ( 28849263 )
2017
29
Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis. ( 28883687 )
2017
30
Establishing tools for early diagnosis of congenital toxoplasmosis: Flow cytometric IgG avidity assay as a confirmatory test for neonatal screening. ( 28827190 )
2017
31
Seroprevalence and determinants of toxoplasmosis in pregnant women attending antenatal clinic at the university teaching hospital, Lusaka, Zambia. ( 28056829 )
2017
32
A rare case of pulmonary toxoplasmosis in a patient with undifferentiated inflammatory arthritis on chronic methotrexate and corticosteroid therapy. ( 28835429 )
2017
33
Birds and poultries toxoplasmosis in Iran: A systematic review and meta-analysis. ( 28870339 )
2017
34
The use of ELISA, nPCR and qPCR for diagnosis of ocular toxoplasmosis in experimentally infected pigs. ( 28787692 )
2017
35
Ocular Lesions in Congenital Toxoplasmosis in Santa Isabel do IvaA-, ParanA!, Brazil. ( 28640004 )
2017
36
T cell immunoregulation in active ocular toxoplasmosis. ( 28214536 )
2017
37
Causes of visual impairment in patients with ocular toxoplasmosis. ( 28248682 )
2017
38
Toxoplasmosis - Awareness and knowledge among medical doctors in Nigeria. ( 29261738 )
2017
39
Extensive brain masses and cavitary lung lesions associated with toxoplasmosis and acquired immunodeficiency syndrome. ( 28632476 )
2017
40
Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study. ( 29020481 )
2017
41
Neuroimaging Findings of Congenital Toxoplasmosis, Cytomegalovirus, and Zika Virus Infections: A Comparison of Three Cases. ( 28780216 )
2017
42
Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets. ( 28086758 )
2017
43
Impact of alternative treatment approach for cerebral toxoplasmosis among HIV/AIDS patients from a resource-poor setting in Burkina Faso ( 29274210 )
2017
44
A critical assessment of the association between postnatal toxoplasmosis and epilepsy in immune-competent patients. ( 28083719 )
2017
45
Congenital toxoplasmosis in Austria: Prenatal screening for prevention is cost-saving. ( 28692640 )
2017
46
Seroprevalence and Manifestations of Ocular Toxoplasmosis in Patients with Schizophrenia. ( 29283732 )
2017
47
Early serum biomarker networks in infants with distinct retinochoroidal lesion status of congenital toxoplasmosis. ( 28254558 )
2017
48
In Reply: Sulfadoxine-Pyrimethamine Combination in Congenital Toxoplasmosis. ( 28187119 )
2017
49
Sulfadoxine-Pyrimethamine Combination in Congenital Toxoplasmosis. ( 28187118 )
2017
50
Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea. ( 28877569 )
2017

Variations for Toxoplasmosis

Expression for Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for Toxoplasmosis

Pathways related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 CCR5 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1
2
Show member pathways
13.75 CCR5 CD40 CD40LG IFNG IL10 IL1B
3
Show member pathways
13.55 CCR5 CD40 CD40LG IL10 IL1B IL4
4
Show member pathways
13.46 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
5
Show member pathways
13.39 CCR5 CD40 CD40LG IL10 IL1B IL4
6
Show member pathways
13.34 CD40 CD79A HLA-DQA1 HLA-DQB1 IFNG IL1B
7
Show member pathways
13.05 IL1B IL6 MYD88 TLR4 TLR9 TNF
8
Show member pathways
12.95 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG IL10
9
Show member pathways
12.87 CD40 CD40LG IL1B IL6 MYD88 TLR4
10
Show member pathways
12.87 HLA-DQA1 HLA-DQB1 IFNG IL1B IL4 IL6
11
Show member pathways
12.79 IFNG IL1B IL6 MYD88 TNF
12
Show member pathways
12.78 CCR5 CD40 CD40LG IFNG IL1B TNF
13
Show member pathways
12.77 CD40 CD40LG IL1B MYD88 TLR4 TLR9
14
Show member pathways
12.77 CD40 CD40LG CD79A HLA-DQA1 HLA-DQB1 IFNG
15
Show member pathways
12.73 HLA-DQA1 HLA-DQB1 IFNG IL10 IL1B IL4
16
Show member pathways
12.67 IFNG IL10 IL1B IL6 TNF
17
Show member pathways
12.66 CCR5 IL6 MYD88 TLR4 TNF
18 12.66 CD40LG CD79A IFNG IL10 IL1B IL4
19
Show member pathways
12.6 CD40 IFNG IL10 IL1B IL6 MYD88
20
Show member pathways
12.58 CCR5 CD40LG IFNG IL10 IL1B IL4
21 12.53 CD40 HLA-DQA1 HLA-DQB1 IL6 TNF
22
Show member pathways
12.5 DHFR IFNG IL1B IL4 IL6 TNF
23
Show member pathways
12.45 IFNG IL1B IL4 IL6 TNF
24
Show member pathways
12.44 CD40 CD40LG HLA-DQA1 HLA-DQB1
25
Show member pathways
12.44 IFNG IL1B IL6 MYD88 TLR4 TNF
26
Show member pathways
12.43 IFNG IL10 IL4 IL6
27 12.42 CD40 HLA-DQA1 HLA-DQB1 IFNG IL10
28
Show member pathways
12.39 IL6 MYD88 TLR4 TLR9 TNF
29
Show member pathways
12.34 IFNG IL10 IL1B IL4 IL6 TNF
30 12.32 IFNG IL6 TLR4 TLR9 TNF
31
Show member pathways
12.29 IFNG IL1B TLR4 TNF
32 12.26 IL10 IL1B IL6 TNF
33
Show member pathways
12.22 IFNG IL1B IL4 IL6 MYD88 TLR4
34
Show member pathways
12.21 CCR5 CD40 CD40LG HLA-DQA1 HLA-DQB1 IFNG
35 12.2 CD40 CD40LG HLA-DQA1 HLA-DQB1
36 12.2 IFNG IL1B IL4 IL6 TLR4 TNF
37 12.18 CD79A IFNG IL10 IL4 IL6 TNF
38 12.15 IL10 IL1B IL4 IL6 TNF
39 12.1 HLA-DQA1 HLA-DQB1 IL1B IL4 IL6 TNF
40 12.09 IFNG IL10 IL1B IL6 TLR4 TNF
41
Show member pathways
12.09 IFNG IL10 IL1B IL6 TLR4 TLR9
42
Show member pathways
12.08 CCR5 IFNG IL1B IL4
43 12.08 CD40 CD40LG IL1B MYD88 TLR4 TNF
44
Show member pathways
12.05 IFNG IL1B IL4 IL6 TLR4 TLR9
45 12.01 IFNG IL1B IL6 MYD88 TLR4
46 11.98 IFNG IL10 IL1B IL4 TNF
47 11.95 CCR5 IFNG IL10 IL6
48 11.95 IL10 IL1B IL6 MYD88 TLR4 TNF
49 11.93 IFNG IL10 IL1B IL6 TLR9 TNF
50 11.93 HLA-DQA1 HLA-DQB1 IFNG IL1B IL6 TLR4

GO Terms for Toxoplasmosis

Cellular components related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CD40 CD40LG IFNG IL10 IL1B IL4
2 integral component of plasma membrane GO:0005887 9.86 CCR5 CD40 CD40LG CD79A HLA-DQA1 RHD
3 extracellular space GO:0005615 9.81 CD40 CD40LG IFNG IL10 IL1B IL4
4 endosome membrane GO:0010008 9.35 HLA-DQA1 HLA-DQB1 MYD88 TLR4 TLR9
5 external side of plasma membrane GO:0009897 9.1 CCR5 CD40 CD40LG CD79A TLR4 TNF

Biological processes related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 CD40 IFNG IL1B TNF
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.96 IL10 IL1B IL6 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 CD40 IL1B MYD88 TLR4 TLR9 TNF
4 cellular response to mechanical stimulus GO:0071260 9.94 CD40 IL1B MYD88 TLR4
5 B cell differentiation GO:0030183 9.93 CD40LG CD79A IL10 IL4
6 defense response to Gram-negative bacterium GO:0050829 9.92 IL6 TLR4 TLR9
7 T cell costimulation GO:0031295 9.92 CD40LG HLA-DQA1 HLA-DQB1
8 apoptotic signaling pathway GO:0097190 9.92 CD40 TLR4 TNF
9 positive regulation of T cell proliferation GO:0042102 9.92 CD40LG IL1B IL4 IL6
10 regulation of inflammatory response GO:0050727 9.91 MYD88 TLR4 TNF
11 interferon-gamma-mediated signaling pathway GO:0060333 9.91 HLA-DQA1 HLA-DQB1 IFNG
12 regulation of insulin secretion GO:0050796 9.91 IFNG IL1B TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 IFNG IL1B TLR4 TNF
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 CD40 IFNG IL6
15 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 IL6 MYD88 TNF
17 humoral immune response GO:0006959 9.89 IFNG IL6 TNF
18 positive regulation of B cell proliferation GO:0030890 9.89 CD40 IL4 TLR4 TLR9
19 positive regulation of tumor necrosis factor production GO:0032760 9.87 MYD88 TLR4 TLR9
20 protein kinase B signaling GO:0043491 9.87 CD40 IL1B TNF
21 B cell proliferation GO:0042100 9.87 CD40 CD40LG CD79A IL10
22 toll-like receptor signaling pathway GO:0002224 9.86 MYD88 TLR4 TLR9
23 positive regulation of interferon-gamma production GO:0032729 9.86 IL1B TLR4 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 IL1B MYD88 TLR4 TNF
25 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 MYD88 TLR4 TLR9
26 positive regulation of JNK cascade GO:0046330 9.85 IL1B MYD88 TLR4 TLR9 TNF
27 cellular response to lipopolysaccharide GO:0071222 9.85 CCR5 CD40 IL10 IL6 TLR4 TNF
28 B cell activation GO:0042113 9.84 CD40 CD79A IL4
29 positive regulation of interleukin-10 production GO:0032733 9.83 CD40LG TLR4 TLR9
30 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR4 TLR9 TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 IFNG IL1B TNF
32 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TLR9 TNF
33 negative regulation of growth of symbiont in host GO:0044130 9.8 IL10 MYD88 TNF
34 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 IL1B TLR4 TLR9 TNF
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 IL10 IL1B TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.77 IL1B MYD88 TNF
37 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 CD40 CD40LG IL1B IL6 MYD88 TLR4
38 response to molecule of bacterial origin GO:0002237 9.75 IL10 TLR9
39 I-kappaB phosphorylation GO:0007252 9.75 TLR4 TLR9
40 regulation of cytokine secretion GO:0050707 9.75 TLR4 TLR9
41 negative regulation of interleukin-17 production GO:0032700 9.75 IFNG TLR4
42 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 IL10 IL4 TLR4
43 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
44 negative regulation of lipid storage GO:0010888 9.74 IL6 TNF
45 positive regulation of isotype switching to IgG isotypes GO:0048304 9.74 CD40 IL4
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
47 positive regulation of lymphocyte proliferation GO:0050671 9.73 MYD88 TLR4
48 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 MYD88 TLR4 TLR9 TNF
49 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
50 response to peptidoglycan GO:0032494 9.72 IL6 MYD88

Molecular functions related to Toxoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CD40LG IFNG IL10 IL1B IL4 IL6
2 MHC class II receptor activity GO:0032395 9.16 HLA-DQA1 HLA-DQB1
3 interleukin-1 receptor binding GO:0005149 9.13 IL1B MYD88 TLR9

Sources for Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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