MCID: TXP001
MIFTS: 62

Toxoplasmosis malady

Infectious diseases category

Summaries for Toxoplasmosis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards: Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to congenital toxoplasmosis and hepatitis. An important gene associated with Toxoplasmosis is CD40LG (CD40 ligand), and among its related pathways are PTEN Pathway and Metabolism. The drugs sulfadiazine and trimethoprim sulfate and the compounds alpha-linolenic acid and u 73343 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A coccidiosis that has material basis in protozoan toxoplasma gondii. the parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission by mother to fetus. the symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC:3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia:63 Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects... more...

Aliases & Classifications for Toxoplasmosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

toxoplasmosis 8 10 44 33 60
multisystemic disseminated toxoplasmosis 60
disseminated toxoplasmosis 8


External Ids:

Disease Ontology8 DOID:9965
MeSH34 D014123
ICD9CM27 130, 130.9
NCIt39 C3418
ICD1025 B58, B58.8, B58.9

Related Diseases for Toxoplasmosis

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17GeneCards, 18GeneDecks
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Diseases in the Congenital Toxoplasmosis family:

toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1congenital toxoplasmosis31.8CD79A, CD40LG
2hepatitis30.3CD40LG
3tuberculosis30.2IL17A, CD79A, IRGM, DHFR, ADK
4cryptosporidiosis30.1DHFR, CD79A
5uveitis30.1IL17A
6encephalitis30.0IL17A, IDO1
7lupus erythematosus29.9CD79A, CD40LG
8vasculitis29.9CD79A, IL17A, CD40LG
9rheumatoid arthritis29.7COL2A1, IDO1, DHFR, IL17A, PLA2G10, CD40LG
10arthritis29.7COL2A1, IDO1, IL17A
11hepatitis b29.7CD79A, DHFR
12lyme disease29.7CD40LG
13candidiasis29.7CD79A
14cerebritis10.7
15chorioretinitis10.5
16retinitis10.5
17ocular toxoplasmosis10.3
18choroiditis10.3
19acquired immunodeficiency syndrome10.3
20rubella10.3
21pneumocystosis10.2
22syphilis10.2
23louping ill10.2
24hydrocephalus10.2
25neuroretinitis10.1
26diabetes insipidus10.1
27toxocariasis10.1
28listeriosis10.1
29cataract10.1
30iridocyclitis10.1
31meningitis10.1
32schizophrenia10.1
33leptospirosis10.0
34sarcocystosis10.0
35brucellosis10.0
36nephrotic syndrome10.0
37hypersensitivity reaction type ii disease10.0CD79A, IDO1, CD40LG, IL17A, LAT
38atherosclerosis10.0IL17A, CD40LG, PLA2G10, IDO1
39immunodeficiency, common variable, 710.0DHFR, CD79A, CD40LG
40immunoglobulin g deficiency10.0CD40LG, CD79A
41connective tissue disease10.0CD79A, CD40LG
42autoimmune hemolytic anemia10.0CD79A, CD40LG
43selective iga deficiency disease10.0CD40LG, CD79A
44crohn's disease10.0IRGM
45immunodeficiency, centromere instability and facial anomalies syndrome10.0CD79A, CD40LG
46immunoglobulin alpha deficiency10.0CD79A, CD40LG
47thrombocytopenia10.0CD40LG, CD79A
48guillain-barre syndrome10.0CD40LG
49immunodeficiency with hyper igm type 110.0CD79A, CD40LG
50asthma10.0IL17A, IDO1, CD79A

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to toxoplasmosis

Clinical Features for Toxoplasmosis

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Drugs & Therapeutics for Toxoplasmosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Toxoplasmosis

Drug clinical trials:

Search ClinicalTrials for Toxoplasmosis

Search NIH Clinical Center for Toxoplasmosis

Search CenterWatch for Toxoplasmosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Toxoplasmosis

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Anatomical Context for Toxoplasmosis

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32MalaCards
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MalaCards organs/tissues related to Toxoplasmosis:

32
Brain, Eye, Testes, T cells, Placenta, Pituitary, Spinal cord, Heart, Kidney, B cells, Nk cells, Whole blood, Endothelial, Fetal brain, Medulla oblongata, Monocytes, Myeloid, Tonsil, Lymph node, Spleen, Skin, Breast, Colon, Retina

Animal Models for Toxoplasmosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Toxoplasmosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.0ADK, IRGM, CD40LG, CD79A, IL17A, ABCA4

Publications for Toxoplasmosis

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50PubMed
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Articles related to Toxoplasmosis:

(show top 50)    (show all 1313)
idTitleAuthorsYear
1
Toxoplasmosis in pregnancy in an area with low seroprevalence: is prenatal screening still worthwhile? (24064557)
2014
2
It is not only the cat that did it: How to prevent and treat congenital toxoplasmosis. (24119928)
2014
3
Congenital toxoplasmosis. (23987732)
2013
4
Prevalence of congenital toxoplasmosis among a series of Turkish women. (23900368)
2013
5
Congenital toxoplasmosis: continued parasite proliferation in the fetal brain despite maternal immunological control in other tissues. (23074307)
2013
6
Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. (23270807)
2013
7
Toxoplasmosis: Experimental Vaginal Infection in NMRI Mice and Its Effect on Uterin, Placenta and Fetus Tissues. (24396580)
2013
8
Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders. (23533776)
2013
9
IgG western blot for confirmatory diagnosis of equivocal cases of toxoplasmosis by EIA-IgG and fluorescent antibody test. (24039295)
2013
10
Clinical features and treatment of ocular toxoplasmosis. (24039281)
2013
11
Neonatal hepatitis with toxoplasmosis. (24027699)
2012
12
Serological IgG avidity test for ocular toxoplasmosis. (22291456)
2012
13
Toxoplasmosis hospitalizations in the United States, 2008, and trends, 1993-2008. (22267718)
2012
14
Anti-Toxoplasma antibody prevalence, primary infection rate, and risk factors in a study of toxoplasmosis in 4,466 pregnant women in Japan. (22205659)
2012
15
Immunological responses induced by a DNA vaccine expressing RON4 and by immunogenic recombinant protein RON4 failed to protect mice against chronic toxoplasmosis. (21983362)
2011
16
An ophthalmologist survey-based study of the atypical presentations and current treatment practices of ocular toxoplasmosis in India. (23024497)
2011
17
Congenital toxoplasmosis: evaluation of molecular and serological methods for achieving economic and early diagnosis among Egyptian preterm infants. (20961951)
2011
18
Cerebellar toxoplasmosis in HIV/AIDS: a case report. (20544640)
2010
19
Migraine associated with patent foramen ovale may be caused by reactivation of cerebral toxoplasmosis triggered by arterial blood oxygen desaturation. (20199198)
2010
20
Direct genotypic characterization of Toxoplasma gondii strains associated with congenital toxoplasmosis in Tunisia (North Africa). (20519598)
2010
21
Molecular diagnosis of cerebral toxoplasmosis: comparing markers that determine Toxoplasma gondii by PCR in peripheral blood from HIV-infected patients. (20963318)
2010
22
Hearing loss in congenital toxoplasmosis detected by newborn screening. (18392497)
2008
23
Intravitreal bevacizumab (Avastin) as primary and rescue treatment for choroidal neovascularization secondary to ocular toxoplasmosis. (18401552)
2008
24
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review. (19108794)
2008
25
Disease burden of congenital toxoplasmosis. (17479945)
2007
26
Cord blood screening for congenital toxoplasmosis in northwestern Switzerland, 1982-1999. (16462288)
2006
27
Congenital toxoplasmosis from an HIV-infected woman as a result of reactivation. (16043225)
2006
28
Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice. (16991094)
2006
29
Association between congenital toxoplasmosis and parent-reported developmental outcomes, concerns, and impairments, in 3 year old children. (16014166)
2005
30
Fuchs' heterochromic iridocyclitis following bilateral ocular toxoplasmosis. (15209468)
2004
31
Bax-induced apoptosis not demonstrated in the congenital toxoplasmosis in mice. (11226731)
2001
32
Ophthalmological findings in children with congenital toxoplasmosis. Report from a Swedish prospective screening study of congenital toxoplasmosis with two years of follow-up. (11037917)
2000
33
Protective immunity in the rat model of congenital toxoplasmosis and the potential of excreted-secreted antigens as vaccine components. (10320624)
1999
34
Seroepidemiology of ocular toxoplasmosis-profile of an urban population. (9866896)
1998
35
Prenatal diagnosis of congenital toxoplasmosis: comparative value of fetal blood and amniotic fluid using serological techniques and cultures. (9316127)
1997
36
Evaluation of the activities of rifabutin combined with atovaquone or low-dose of cotrimoxazole for prevention of pneumocystosis and toxoplasmosis in a dual infection rat model. (8822822)
1996
37
Congenital toxoplasmosis in the Balb/c mouse: prevention of vertical disease transmission and fetal death by vaccination. (7887016)
1994
38
Coccidian infections in AIDS. Toxoplasmosis, cryptosporidiosis, and isosporiasis. (1727538)
1992
39
Absence of sensorineural hearing loss in treated infants and children with congenital toxoplasmosis. (1734373)
1992
40
Congenital toxoplasmosis and TORCH. (1975389)
1990
41
Detection of congenital toxoplasmosis by chorionic villus sampling and early amniocentesis. (2240098)
1990
42
Hypothalamo-pituitary dysfunction in congenital toxoplasmosis. (2792124)
1989
43
Serology in ocular toxoplasmosis. (3741830)
1986
44
Retinal vasculitis in ocular toxoplasmosis in nonhuman primates. (6387835)
1984
45
Congenital toxoplasmosis. (6722060)
1984
46
Congenital toxoplasmosis in Tasmania. (651703)
1978
47
Congenital toxoplasmosis. (704130)
1978
48
Disseminated cytomegalic inclusion disease and disseminated toxoplasmosis in an adult with myeloid metaplasia; report of a case. (13292382)
1956
49
Congenital ocular toxoplasmosis. (14929406)
1952
50
RAPID AND STERILIZING EFFECT OF PENICILLIN SODIUM IN EXPERIMENTAL RELAPSING FEVER INFECTIONS AND ITS INEFFECTIVENESS IN THE TREATMENT OF TRYPANOSOMIASIS (TRYPANOSOMA LEWISI) AND TOXOPLASMOSIS. (17844553)
1944

Genetic Variations for Toxoplasmosis

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Expression for genes affiliated with Toxoplasmosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for genes affiliated with Toxoplasmosis

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8COL2A1, CD79A, PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
2
Hide members
10.8DHFR, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
3
Hide members
10.8CD79A, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
4
Hide members
10.8HLA-DOB, PLA2G10, PLA2G3, PLA2G12B, PLA2G2E, LAT
5
Hide members
10.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E, LAT
6
Hide members
10.7PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
7
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
8
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
910.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
10
Hide members
10.7PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
11
Hide members
10.7CD40LG, CD79A, IL17A, LAT
12
Hide members
10.7IL17A, CD40LG, HLA-DOB, IRGM
13
Hide members
10.7PLA2G2E, PLA2G12B, PLA2G3, PLA2G10
1410.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
1510.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
1610.7PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
17
Immune response NFAT in immune response
Hide members
10.6HLA-DOB, CD79A, LAT
18
Anandamide biosynthesis and metabolism
Hide members
10.6PLA2G2E, PLA2G3, PLA2G10

Compounds for genes affiliated with Toxoplasmosis

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1alpha-linolenic acid44 11 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
2u 733435911.1PLA2G12B, PLA2G4B, PLA2G3, PLA2G10, PLA2G2E
3m-3m3fbs5911.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
4fipi5911.1PLA2G10, PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3
5d6095911.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
6edelfosine44 5912.1PLA2G10, PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E
7linoleic acid44 28 2413.1PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
8arginine4411.0COL2A1, IDO1, CD40LG, CD79A, DHFR, ADK
9stearic acid44 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
10pge24411.0IDO1, CD40LG, CD79A, IL17A, PLA2G10
11palmitic acid28 11 2413.0PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
12arachidonic acid44 28 11 2414.0PLA2G2E, PLA2G12B, PLA2G4B, PLA2G3, PLA2G10
13myristic acid44 11 2413.0PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
14pteridine4411.0IDO1, DHFR, ADK
15pneumococcal4411.0DHFR, CD79A, CD40LG
16glycerol44 11 2413.0CD79A, DHFR, PLA2G10, PLA2G2E
17mannan4410.9IL17A, CD79A, CD40LG
18sulfolipid i4410.9CD79A, CD40LG
19sandoglobulin4410.9CD40LG, CD79A
20anti-fungal4410.9CD40LG, CD79A, DHFR
21ascorbic acid44 2411.9DHFR, CD79A, CD40LG, COL2A1
22neopterin4410.9CD79A, CD40LG, IDO1
23theophylline44 28 11 2413.8CD40LG, CD79A, ADK
24calcium44 49 11 2413.7COL2A1, IDO1, PLA2G10, PLA2G3, PLA2G4B, PLA2G12B
25dexamethasone44 49 28 1113.7IL17A, CD79A, CD40LG, IDO1, COL2A1
26vancomycin44 1111.7CD79A, CD40LG
27blys4410.7CD40LG, CD79A
28tuberculin4410.6CD79A, CD40LG
29praziquantel44 1111.6CD79A, CD40LG
30hemocyanin4410.3CD40LG, CD79A

GO Terms for genes affiliated with Toxoplasmosis

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16Gene Ontology
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Biological processes related to Toxoplasmosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylglycerol acyl-chain remodelingGO:03614810.9PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
2phosphatidylethanolamine acyl-chain remodelingGO:03615210.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
3phosphatidylcholine acyl-chain remodelingGO:03615110.9PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
4lipid catabolic processGO:01604210.8PLA2G10, PLA2G3, PLA2G12B, PLA2G2E
5inflammatory responseGO:00695410.8PLA2G2E, PLA2G4B, IL17A, CD40LG, IRGM
6glycerophospholipid biosynthetic processGO:04647410.8PLA2G10, PLA2G3, PLA2G4B, PLA2G2E
7phosphatidylserine acyl-chain remodelingGO:03615010.8PLA2G2E, PLA2G4B, PLA2G10
8phosphatidic acid biosynthetic processGO:00665410.6PLA2G10, PLA2G4B, PLA2G2E
9phosphatidylinositol acyl-chain remodelingGO:03614910.6PLA2G2E, PLA2G10
10phospholipid metabolic processGO:00664410.6PLA2G2E, PLA2G4B, PLA2G3, PLA2G10
11B cell proliferationGO:04210010.3CD79A, CD40LG

Molecular functions related to Toxoplasmosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium ion bindingGO:00550910.7PLA2G3, PLA2G4B, PLA2G12B, PLA2G2E, PLA2G10
2phospholipase A2 activityGO:00462310.5PLA2G2E, PLA2G12B, PLA2G10
3calcium-dependent phospholipase A2 activityGO:04749810.3PLA2G4B, PLA2G3

Products for genes affiliated with Toxoplasmosis

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  • Antibodies
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Sources for Toxoplasmosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet