MCID: TXP001
MIFTS: 61

Toxoplasmosis malady

Categories: Infectious diseases, Rare diseases, Fetal diseases, Neuronal diseases

Aliases & Classifications for Toxoplasmosis

Aliases & Descriptions for Toxoplasmosis:

Name: Toxoplasmosis 12 52 41 3 42 14 69
Multisystemic Disseminated Toxoplasmosis 69
Disseminated Toxoplasmosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9965
ICD10 33 B58 B58.9 B58.8
ICD9CM 35 130 130.9
MeSH 42 D014123
NCIt 47 C3418
UMLS 69 C0040558

Summaries for Toxoplasmosis

MedlinePlus : 41 toxoplasmosis is a disease caused by the parasite toxoplasma gondii. more than 60 million people in the u.s. have the parasite. most of them don't get sick. but the parasite causes serious problems for some people. these include people with weak immune systems and babies whose mothers become infected for the first time during pregnancy. problems can include damage to the brain, eyes, and other organs. you can get toxoplasmosis from waste from an infected cat eating contaminated meat that is raw or not well cooked using utensils or cutting boards after they've had contact with contaminated raw meat drinking infected water receiving an infected organ transplant or blood transfusion most people with toxoplasmosis don't need treatment. there are drugs to treat it for pregnant women and people with weak immune systems. centers for disease control and prevention

MalaCards based summary : Toxoplasmosis, also known as multisystemic disseminated toxoplasmosis, is related to microcephaly and chorioretinitis, and has symptoms including fever and pruritus. An important gene associated with Toxoplasmosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Sulfadiazine and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A coccidiosis that has material basis in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

CDC : 3 Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 30 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

Wikipedia : 71 Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Infections with toxoplasmosis usually... more...

Related Diseases for Toxoplasmosis

Diseases in the Toxoplasmosis family:

Congenital Toxoplasmosis

Diseases related to Toxoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 501)
id Related Disease Score Top Affiliating Genes
1 microcephaly 31.8 IFNG IL10 TLR2 TNF
2 chorioretinitis 30.4 CD40LG IFNG IL10 TNF
3 uveitis 30.1 CD40LG CD79A TNF
4 choroiditis 29.8 IL10 IL1B IL6 TLR4 TNF
5 hepatitis 29.8 IFNG IL10 IL6 TNF
6 rabies 29.6 CD40LG CD79A
7 cryptococcosis 29.5 CD40LG IL10 TNF
8 tuberculosis 29.3 CD40LG IL10 IL1B IL4 IL6 TLR9
9 central nervous system lymphoma 29.2 IL10 IL1B IL6 TNF
10 neonatal jaundice 29.1 IFNG IL10 IL4 IL6 TNF
11 polyarteritis nodosa 29.0 IFNG MYD88 TLR2 TLR4 TLR9
12 tularemia 29.0 CD40LG CD79A IFNG IL10 IL4 TLR9
13 pulmonary tuberculosis 28.7 CD40LG IFNG IL10 IL4 IL6 TLR4
14 rheumatoid arthritis 28.2 CD40LG CD79A IFNG IL10 IL1B IL4
15 congenital toxoplasmosis 12.4
16 ocular toxoplasmosis 12.3
17 cytomegalic inclusion disease 11.1
18 hydrocephalus, nonsyndromic, autosomal recessive 10.8
19 alcoholic neuropathy 10.4 CD40LG CD79A
20 camptodactyly vertebral fusion 10.4 CD40LG CD79A
21 myoglobinuria recurrent 10.4 IFNG IL4
22 spinal polio 10.4 CD40LG CD79A
23 unilateral retinoblastoma 10.3 CD40LG CD79A
24 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
25 intussusception 10.3 IL1B TNF
26 delta chain disease 10.3 CD40LG CD79A
27 maturity-onset diabetes of the young 10.3 CD40LG IL10
28 discitis 10.3 CD40LG CD79A
29 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
30 trichostrongyloidiasis 10.3 CD40LG CD79A
31 alkhurma hemorrhagic fever 10.3 CD40LG CD79A IL4
32 colloid adenoma 10.3 CD40LG CD79A
33 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
34 polyneuropathy due to drug 10.3 CD40LG CD79A IL4
35 cutaneous ganglioneuroma 10.3 CD40LG CD79A IL4
36 odontogenic myxoma 10.3 CD40LG CD79A TLR9
37 intravascular angioleiomyoma 10.3 CD40LG CD79A IL4
38 hemangioma of orbit 10.3 CD40LG CD79A TNF
39 asymptomatic neurosyphilis 10.3 IFNG IL10 IL4
40 abdominal tuberculosis 10.3 CD40LG CD79A IL10
41 ciliary discoordination, due to random ciliary orientation 10.3 CD79A IFNG IL10
42 tungiasis 10.3 IFNG IL10 IL4
43 autoimmune disease of skin and connective tissue 10.3 CD40LG CD79A IFNG
44 mu chain disease 10.3 CD40LG CD79A MYD88
45 barbiturate abuse 10.3 CD40LG CD79A IL4
46 autosomal dominant deafness-onychodystrophy syndrome 10.3 IFNG IL4 TNF
47 hyperparathyroidism, primary, caused by water clear cell hyperplasia 10.3 CD40 CD40LG
48 autonomic peripheral neuropathy 10.3 CD40LG CD79A TLR9
49 colonic benign neoplasm 10.3 CD40LG CD79A MYD88
50 dermatomycosis 10.3 CD40LG CD79A TNF

Graphical network of the top 20 diseases related to Toxoplasmosis:



Diseases related to Toxoplasmosis

Symptoms & Phenotypes for Toxoplasmosis

UMLS symptoms related to Toxoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Toxoplasmosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.78 CD40LG DHFR IL10 IL1B MYD88 NLRP1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.78 DHFR IL10 IL1B MYD88 NLRP1 TNF

MGI Mouse Phenotypes related to Toxoplasmosis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.47 CD40LG CD79A IFNG IL10 IL1B IL4
2 homeostasis/metabolism MP:0005376 10.45 CCR5 CD40 CD40LG CD79A IFNG IL10
3 immune system MP:0005387 10.41 TNF TRAF6 CCR5 CD40 CD40LG CD79A
4 cellular MP:0005384 10.38 TLR9 TNF TRAF6 CCR5 CD40LG CD79A
5 cardiovascular system MP:0005385 10.32 IFNG IL10 IL1B IL6 MYD88 TLR2
6 mortality/aging MP:0010768 10.3 CCR5 CD40LG DHFR IFNG IL10 IL1B
7 digestive/alimentary MP:0005381 10.26 MYD88 TLR2 TLR4 TLR9 TNF CCR5
8 endocrine/exocrine gland MP:0005379 10.25 TNF TRAF6 CD40 CD40LG IFNG IL10
9 nervous system MP:0003631 10.22 CCR5 CD40 CD40LG CD79A IFNG IL10
10 integument MP:0010771 10.19 CD40LG IFNG IL10 IL1B IL4 IL6
11 liver/biliary system MP:0005370 10.18 CCR5 CD79A IFNG IL10 IL4 IL6
12 neoplasm MP:0002006 10.13 TLR4 TNF CCR5 CD79A IFNG IL10
13 renal/urinary system MP:0005367 10.06 CD40 CD40LG CD79A IFNG IL4 IL6
14 reproductive system MP:0005389 9.96 IL4 IL6 MYD88 TLR4 TNF TRAF6
15 no phenotypic analysis MP:0003012 9.91 CCR5 CD79A IFNG IL10 IL4 MYD88
16 respiratory system MP:0005388 9.76 IFNG IL10 IL4 IL6 MYD88 TLR2
17 skeleton MP:0005390 9.73 CD40 CD40LG IFNG IL10 IL1B IL4
18 vision/eye MP:0005391 9.28 CCR5 IFNG IL10 IL4 IL6 MYD88

Drugs & Therapeutics for Toxoplasmosis

Drugs for Toxoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfadiazine Approved, Vet_approved Phase 4,Phase 3,Phase 2 68-35-9 5215
2
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 58-14-0 4993
3
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
5
Bevacizumab Approved, Investigational Phase 4 216974-75-3
6
Spiramycin Approved Phase 4,Phase 3 24916-50-5
7
Levoleucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1 68538-85-2
8
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
9
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
11 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
12 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Trace Elements Phase 4,Phase 3
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
21 Angiogenesis Inhibitors Phase 4
22 Angiogenesis Modulating Agents Phase 4
23 Vitamins Phase 4,Phase 3
24 Antidotes Phase 4,Phase 3,Phase 2,Phase 1
25 Micronutrients Phase 4,Phase 3
26 Calcium, Dietary Phase 4,Phase 2,Phase 1
27 Bone Density Conservation Agents Phase 4
28 GABA Agents Phase 4
29 Neurotransmitter Agents Phase 4
30 Tranquilizing Agents Phase 4
31 Anticonvulsants Phase 4
32 Psychotropic Drugs Phase 4
33 Antimanic Agents Phase 4
34 Central Nervous System Depressants Phase 4
35 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
36 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
37
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
38
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
39
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
40
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
41
Zidovudine Approved Phase 3,Phase 1 30516-87-1 35370
42
Fluconazole Approved Phase 3 86386-73-4 3365
43
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
44
Azithromycin Approved Phase 3,Phase 1 83905-01-5 55185 53477736 447043
45
Dapsone Approved, Investigational Phase 3 80-08-0 2955
46
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
47
Rifabutin Approved Phase 3 72559-06-9 6323490
48
Pentamidine Approved Phase 3 100-33-4 4735
49 Prednisolone acetate Phase 3
50 Dexamethasone acetate Phase 3 1177-87-3

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4
2 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697 Phase 4
3 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4
4 Pilot Trial of Valproate as Adjunctive Treatment for Toxoplasma Gondii Infection in Early Course Schizophrenia Active, not recruiting NCT02011750 Phase 4
5 Assessment of Two Therapeutic Strategies in the Treatment of Children With Congenital Toxoplasmosis Unknown status NCT01202500 Phase 3
6 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3
7 Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis Completed NCT01449877 Phase 3
8 Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy Completed NCT01189448 Phase 3
9 Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression Completed NCT00300404 Phase 3
10 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3
11 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3
12 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3
13 Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients Completed NCT00000643 Phase 2
14 Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis Completed NCT00000794 Phase 2
15 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
16 A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients Completed NCT00000973 Phase 1
17 Antiretroviral Drug Interaction Study in Volunteers With HIV Completed NCT01479361 Phase 1
18 A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS Completed NCT00000966 Phase 1
19 A Phase I Study of Autologous, Activated CD8(+) Lymphocytes Expanded In Vitro and Infused With or Without Recombinant Interleukin-2 to Patients With AIDS or Severe ARC Completed NCT00000680 Phase 1
20 A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis Withdrawn NCT00679744 Phase 1
21 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
22 Cerebral Toxoplasmosis and AIDS Completed NCT00803621
23 A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection Completed NCT00000666
24 A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine Completed NCT00001994
25 A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS Completed NCT00000674
26 Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse Completed NCT00002064
27 Evaluation of Brain Lesions in HIV-infected Patients for Diagnosis of Primary Central Nervous System Lymphoma Completed NCT00226304
28 Drug Exposure Registry for GSK2248761, an Investigational NNRTI Completed NCT01458132
29 Uveitis Gene-Expression Profiling Completed NCT00874471
30 Lyon Cohort of Maternal and Congenital Toxoplasma Infections Recruiting NCT02936921
31 Apheresis of Patients With Immunodeficiency Recruiting NCT01212055
32 Expanded Noninvasive Genomic Medical Assessment: The Enigma Study Recruiting NCT02787486
33 Determination of Genetic Susceptibility in Severe Recurrences of Ocular Toxoplasmosis Not yet recruiting NCT02863588
34 Clinical Studies of Kikuchi's Disease Withdrawn NCT00172445

Search NIH Clinical Center for Toxoplasmosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: toxoplasmosis

Genetic Tests for Toxoplasmosis

Anatomical Context for Toxoplasmosis

MalaCards organs/tissues related to Toxoplasmosis:

39
Eye, Brain, Testes, Lymph Node, T Cells, Kidney, Placenta

Publications for Toxoplasmosis

Articles related to Toxoplasmosis:

(show top 50) (show all 1534)
id Title Authors Year
1
A critical assessment of the association between postnatal toxoplasmosis and epilepsy in immune-competent patients. ( 28083719 )
2017
2
Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets. ( 28086758 )
2017
3
Toxoplasmosis with chorioretinitis in an HIV-infected child with no visual complaints-importance of fundus examination. ( 28058107 )
2017
4
Toxoplasmosis versus lymphoma: Cerebral lesion characterization using DSC-MRI revisited. ( 27940418 )
2017
5
Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. ( 27723657 )
2017
6
Seroprevalence and determinants of toxoplasmosis in pregnant women attending antenatal clinic at the university teaching hospital, Lusaka, Zambia. ( 28056829 )
2017
7
Congenital toxoplasmosis: Clinical features, outcomes, treatment, and prevention. ( 27722099 )
2016
8
Toxoplasmosis and cancer: Current knowledge and research perspectives. ( 27586960 )
2016
9
Toxoplasmosis in camels (Camelus dromedarius) of Borana zone, Oromia region, Ethiopia: seroprevalence and risk factors. ( 27554500 )
2016
10
Outbreak of ovine congenital toxoplasmosis in Iran, confirmed by different diagnostic methods. ( 27065616 )
2016
11
Performance of Polymerase Chain Reaction Analysis of the Amniotic Fluid of Pregnant Women for Diagnosis of Congenital Toxoplasmosis: A Systematic Review and Meta-Analysis. ( 27055272 )
2016
12
Prenatal and Early Postnatal Diagnosis of Congenital Toxoplasmosis in a Setting With No Systematic Screening in Pregnancy. ( 26945416 )
2016
13
ANTI-TOXOPLASMA ACTIVITY OF ESTRAGOLE AND THYMOL IN MURINE MODELS OF CONGENITAL AND NON-CONGENITAL TOXOPLASMOSIS. ( 26836848 )
2016
14
Effect of honey on mRNA expression of TNF-I+, IL-1I^ and IL-6 following acute toxoplasmosis in mice. ( 27591508 )
2016
15
Prognosis of Fetal Parenchymal Cerebral Lesions without Ventriculomegaly in Congenital Toxoplasmosis Infection. ( 27093552 )
2016
16
WC-9 a Lead Drug with Great Prospects for American Trypanosomiasis and Toxoplasmosis. ( 27290911 )
2016
17
Laboratory diagnosis of congenital toxoplasmosis. ( 27147724 )
2016
18
Re: Freitas-Neto etA al.: Increased submacular choroidal thickness in active, isolated, extramacular toxoplasmosis (Ophthalmology 2016;123:222-4). ( 27107363 )
2016
19
Interpretation of the Elecsys Toxo IgG avidity results for very low and very high index: study on 741 sera with a determined date of toxoplasmosis. ( 27995345 )
2016
20
Listeriosis and Toxoplasmosis in Pregnancy: Essentials for Healthcare Providers. ( 27104604 )
2016
21
Clinical characteristics and computed tomography findings of pulmonary toxoplasmosis after hematopoietic stem cell transplantation. ( 27531150 )
2016
22
Vertical transmission and fetal damage in animal models of congenital toxoplasmosis: A systematic review. ( 27198800 )
2016
23
Incidence of Symptomatic Congenital Toxoplasmosis During 10 Years in a Brazilian Hospital. ( 27455439 )
2016
24
Prenatal toxoplasmosis antibody and childhood autism. ( 27874276 )
2016
25
Molecular diagnosis of toxoplasmosis in immunocompromised patients. ( 27191201 )
2016
26
In Vitro and in Vivo Effects of Nitrofurantoin on Experimental Toxoplasmosis. ( 27180573 )
2016
27
P35 and P22 Toxoplasma gondii antigens abbreviate regions to diagnose acquired toxoplasmosis during pregnancy: toward single-sample assays. ( 27658149 )
2016
28
Effect of Antenatal Treatment on the Severity of Congenital Toxoplasmosis. ( 26689954 )
2016
29
Ocular Toxoplasmosis Reactivation in a Patient With Inflammatory Bowel Disease Under Treatment With Azathioprine. ( 27031813 )
2016
30
Risk and other factors associated with toxoplasmosis and toxocariasis in pregnant women from southern Brazil. ( 27411883 )
2016
31
Cerebral toxoplasmosis in a patient with myasthenia gravis and thymoma with immunodeficiency/Good's syndrome: a case report. ( 27576953 )
2016
32
Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? ( 27741079 )
2016
33
Toxoplasmosis in Iran: A guide for general physicians working in the Iranian health network setting: A systematic review. ( 27999640 )
2016
34
Ocular manifestation of congenital toxoplasmosis, clinical implication - case report. ( 27306134 )
2016
35
Evaluation of Propranolol Effect on Experimental Acute and Chronic Toxoplasmosis using Q-PCR. ( 27645234 )
2016
36
Toxoplasmosis and Toxocariasis: An Assessment of Human Immunodeficiency Virus Comorbidity and Health-Care Costs in Canada. ( 27139453 )
2016
37
Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden. ( 27124472 )
2016
38
IgA and IgG1 reactivities assessed by flow cytometry mirror clinical aspects of infants with ocular congenital toxoplasmosis. ( 26592658 )
2016
39
Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer? ( 27106237 )
2016
40
Toxoplasmosis Neuroretinitis: A Case Report. ( 27340559 )
2016
41
Cytokine Signatures Associated With Early Onset, Active Lesions and Late Cicatricial Events of Retinochoroidal Commitment in Infants With Congenital Toxoplasmosis. ( 26946460 )
2016
42
Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis. ( 28069296 )
2016
43
Congenital Toxoplasmosis in Chronically Infected and Subsequently Challenged Ewes. ( 27788185 )
2016
44
In vivo effect of anti-TNF agent (etanercept) in reactivation of latent toxoplasmosis. ( 27876967 )
2016
45
Treatment of Congenital Toxoplasmosis: Safety of the Sulfadoxine-Pyrimethamine Combination in Children Based on a Method of Causality Assessment. ( 26906163 )
2016
46
Unusual magnetic resonance imaging presentation of post-BMT cerebral toxoplasmosis masquerading as meningoencephalitis and ventriculitis. ( 27348541 )
2016
47
Toxoplasmosis in Nigeria: the story so far (1950-2016): a review. ( 27579591 )
2016
48
Evaluation of recombinant antigens in combination and single formula for diagnosis of feline toxoplasmosis. ( 27876472 )
2016
49
HLA-DQA1/B1 alleles as putative susceptibility markers in congenital toxoplasmosis. ( 26856406 )
2016
50
Cerebral toxoplasmosis in patients with acquired immune deficiency syndrome in the neurological emergency department of a tertiary hospital. ( 27573702 )
2016

Variations for Toxoplasmosis

Expression for Toxoplasmosis

Search GEO for disease gene expression data for Toxoplasmosis.

Pathways for Toxoplasmosis

Pathways related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 CCR5 CD40 CD40LG CD79A IFNG IL10
2
Show member pathways
13.76 CCR5 CD40 CD40LG IFNG IL10 IL1B
3
Show member pathways
13.53 CCR5 CD40 CD40LG IL10 IL1B IL4
4
Show member pathways
13.52 CCR5 CD40 CD40LG IFNG IL10 IL1B
5
Show member pathways
13.4 CCR5 CD40 CD40LG IL10 IL1B IL4
6
Show member pathways
13.34 CD40 CD79A IFNG IL1B IL4 MYD88
7
Show member pathways
13.17 IL1B IL6 MYD88 NLRP1 TLR2 TLR4
8
Show member pathways
13.02 CD40 CD40LG IFNG IL10 IL1B IL4
9
Show member pathways
12.99 CD40 IFNG IL10 IL1B IL6 MYD88
10
Show member pathways
12.95 IFNG IL1B IL4 IL6 MYD88 TLR2
11
Show member pathways
12.85 IFNG IL1B IL6 MYD88 TNF TRAF6
12
Show member pathways
12.84 CCR5 CD40 CD40LG IFNG IL1B TNF
13
Show member pathways
12.84 CD40 CD40LG IL1B IL6 MYD88 TLR2
14
Show member pathways
12.81 CD40 CD40LG CD79A IFNG IL10 IL4
15
Show member pathways
12.79 IFNG IL10 IL1B IL4 IL6 TLR2
16
Show member pathways
12.79 CD40 CD40LG IL1B MYD88 TLR2 TLR4
17
Show member pathways
12.68 IFNG IL10 IL1B IL6 TNF
18 12.64 CD40LG CD79A IFNG IL10 IL1B IL4
19
Show member pathways
12.56 CCR5 CD40LG IFNG IL10 IL1B IL4
20
Show member pathways
12.53 IFNG IL1B IL4 IL6 TLR2 TNF
21
Show member pathways
12.51 DHFR IFNG IL1B IL4 IL6 TNF
22
Show member pathways
12.47 IL6 MYD88 TLR2 TLR4 TLR9 TNF
23
Show member pathways
12.46 IFNG IL1B IL6 MYD88 TLR4 TNF
24 12.38 IFNG IL6 TLR2 TLR4 TLR9 TNF
25
Show member pathways
12.37 CCR5 CD40 CD40LG IFNG IL10 IL1B
26 12.36 CD40 IFNG IL10 TRAF6
27
Show member pathways
12.36 IFNG IL10 IL1B IL4 IL6 TNF
28
Show member pathways
12.29 IFNG IL10 IL4 IL6
29 12.26 IL10 IL1B IL6 TNF
30 12.22 IFNG IL1B IL4 IL6 TLR4 TNF
31 12.2 CD79A IFNG IL10 IL4 IL6 TNF
32 12.17 IL10 IL1B IL4 IL6 TNF
33
Show member pathways
12.16 CCR5 IFNG IL1B IL4 TRAF6
34 12.15 IFNG IL1B TNF TRAF6
35
Show member pathways
12.13 IL1B TLR2 TLR4 TLR9
36
Show member pathways
12.13 IFNG IL1B IL4 IL6 TLR2 TLR4
37 12.07 IFNG IL1B IL6 TLR2 TLR4 TNF
38 12.07 IFNG IL10 IL1B IL6 TLR2 TLR4
39
Show member pathways
12.07 IFNG IL1B IL4 IL6 MYD88 TLR2
40 12.06 CD40 CD40LG IL1B MYD88 TLR4 TNF
41
Show member pathways
12.06 IFNG IL10 IL1B IL6 TLR2 TLR4
42 12.03 IFNG IL1B IL6 MYD88 TLR4
43 12.02 IL1B IL4 IL6 TNF
44
Show member pathways
12 IL6 MYD88 TLR4 TRAF6
45 11.99 IFNG IL10 IL1B IL4 TNF
46 11.98 IFNG IL10 IL1B IL6 TLR9 TNF
47 11.94 IL10 IL1B IL6 MYD88 TLR4 TNF
48
Show member pathways
11.91 CD40LG IFNG IL4 TNF
49 11.91 IFNG IL10 IL1B IL6 MYD88 TLR2
50
Show member pathways
11.89 CD40 CD40LG TNF TRAF6

GO Terms for Toxoplasmosis

Cellular components related to Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 CCR5 CD40 CD40LG CD79A RHD TLR2
2 endosome membrane GO:0010008 9.67 MYD88 TLR4 TLR9 TRAF6
3 cell surface GO:0009986 9.63 CCR5 CD40 CD40LG TLR2 TLR4 TNF
4 extracellular space GO:0005615 9.61 CD40 CD40LG IFNG IL10 IL1B IL4
5 CD40 receptor complex GO:0035631 9.43 CD40 TRAF6
6 external side of plasma membrane GO:0009897 9.28 CCR5 CD40 CD40LG CD79A IFNG IL4
7 cytoplasm GO:0005737 10.17 CCR5 CD40 CD79A DHFR IFNG IL10
8 extracellular region GO:0005576 10.06 CD40 CD40LG IFNG IL10 IL1B IL4

Biological processes related to Toxoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.99 CD40LG CD79A IL10 IL4
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.99 IL6 MYD88 TNF TRAF6
3 positive regulation of T cell proliferation GO:0042102 9.99 CD40LG IFNG IL1B IL4 IL6 TRAF6
4 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.98 MYD88 TLR2 TLR4 TLR9 TRAF6
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.97 CD40 IFNG IL4 IL6
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.97 IL1B MYD88 TLR2 TLR4 TNF
7 B cell proliferation GO:0042100 9.96 CD40 CD40LG CD79A IL10
8 apoptotic signaling pathway GO:0097190 9.95 CD40 TLR4 TNF
9 response to glucocorticoid GO:0051384 9.95 IL10 IL6 TNF
10 response to insulin GO:0032868 9.95 IL10 IL6 TLR2
11 negative regulation of interleukin-6 production GO:0032715 9.95 IL10 TLR4 TLR9 TNF
12 regulation of insulin secretion GO:0050796 9.94 IFNG IL1B TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TLR4 TNF TRAF6
14 positive regulation of inflammatory response GO:0050729 9.93 TLR2 TLR4 TLR9
15 humoral immune response GO:0006959 9.93 IFNG IL6 TNF
16 defense response to Gram-negative bacterium GO:0050829 9.93 IL6 TLR4 TLR9
17 positive regulation of interleukin-8 production GO:0032757 9.93 IL1B TLR2 TLR4 TLR9 TNF
18 immune response GO:0006955 9.93 CCR5 CD40 CD40LG IFNG IL10 IL1B
19 JNK cascade GO:0007254 9.92 MYD88 TNF TRAF6
20 positive regulation of interferon-gamma production GO:0032729 9.92 IL1B TLR4 TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.92 IFNG IL10 MYD88 TNF
22 positive regulation of interleukin-10 production GO:0032733 9.92 CD40LG IL4 TLR2 TLR4 TLR9
23 cellular response to lipopolysaccharide GO:0071222 9.92 CCR5 CD40 IFNG IL10 IL6 TLR4
24 positive regulation of B cell proliferation GO:0030890 9.91 CD40 IL4 TLR4
25 positive regulation of JUN kinase activity GO:0043507 9.9 TLR9 TNF TRAF6
26 response to bacterium GO:0009617 9.9 CD40 IL6 TLR4
27 protein kinase B signaling GO:0043491 9.9 CD40 IL1B TNF
28 B cell activation GO:0042113 9.9 CD40 CD79A IL4
29 positive regulation of interferon-beta production GO:0032728 9.89 TLR2 TLR4 TLR9
30 positive regulation of osteoclast differentiation GO:0045672 9.88 IFNG TNF TRAF6
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.88 IFNG IL1B TNF
32 toll-like receptor 9 signaling pathway GO:0034162 9.88 MYD88 TLR9 TRAF6
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.88 IFNG IL10 IL4 TLR4
34 positive regulation of NF-kappaB import into nucleus GO:0042346 9.88 IL1B TLR2 TLR4 TLR9 TNF
35 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.87 TLR2 TLR4 TLR9
36 response to molecule of bacterial origin GO:0002237 9.86 IL10 TLR2 TLR9
37 I-kappaB phosphorylation GO:0007252 9.86 TLR2 TLR4 TLR9
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.85 IL10 IL1B TNF
39 regulation of cytokine secretion GO:0050707 9.85 TLR2 TLR4 TLR9
40 positive regulation of isotype switching to IgG isotypes GO:0048304 9.85 CD40 IFNG IL4
41 defense response to protozoan GO:0042832 9.85 CD40 IFNG IL10 IL4 IL6
42 positive regulation of interleukin-12 production GO:0032735 9.85 CD40 CD40LG IFNG TLR2 TLR4 TLR9
43 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.84 IFNG IL1B TRAF6
44 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.83 IFNG TLR4 TRAF6
45 positive regulation of chemokine production GO:0032722 9.83 IL6 TLR2 TLR4 TLR9 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.81 IFNG IL1B TNF
47 regulation of immunoglobulin secretion GO:0051023 9.8 CD40 CD40LG TNF TRAF6
48 positive regulation of chemokine biosynthetic process GO:0045080 9.8 IFNG IL1B IL4 MYD88 TNF
49 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 MYD88 TLR2 TLR4 TLR9
50 bone remodeling GO:0046849 9.78 IL6 TRAF6

Molecular functions related to Toxoplasmosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.62 CD79A TLR2 TLR4 TLR9
2 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG TNF TRAF6
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 cytokine activity GO:0005125 9.17 CD40LG IFNG IL10 IL1B IL4 IL6
5 interleukin-1 receptor binding GO:0005149 9.13 IL1B MYD88 TLR9

Sources for Toxoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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