MCID: TRC005
MIFTS: 39

Tracheal Stenosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Tracheal Stenosis

MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 28 41 14 69
Stenosis of Trachea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3227
MeSH 41 D014135
NCIt 46 C78646
SNOMED-CT 64 11296007
UMLS 69 C0040583

Summaries for Tracheal Stenosis

MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to tracheomalacia and tracheitis. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways is O-glycosylation of TSR domain-containing proteins. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart.

Related Diseases for Tracheal Stenosis

Diseases in the Tracheal Stenosis family:

Congenital Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 tracheomalacia 29.9 IYD SLC22A4 TEF
2 tracheitis 29.4 RHNO1 SLC22A4
3 idiopathic subglottic tracheal stenosis 12.2
4 congenital tracheal stenosis 12.2
5 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 12.0
6 tracheobronchial stenosis, congenital 11.5
7 geleophysic dysplasia 1 11.2
8 geleophysic dysplasia 2 11.1
9 geleophysic dwarfism 11.1
10 jung wolff back stahl syndrome 11.1
11 laryngitis 10.3
12 esophagitis 10.2
13 geleophysic dysplasia 10.1 ADAMTSL2 FBN1
14 heart disease 10.1
15 trachea leiomyoma 10.1 SLC22A4 TEF
16 asthma 10.1
17 tracheoesophageal fistula 10.1
18 cervicitis 10.1
19 mediastinitis 10.1
20 aneurysm 10.0
21 diaphragmatic eventration 10.0 FBN1 TEF
22 lung agenesis 10.0
23 mycobacterium tuberculosis 1 10.0
24 burns 10.0
25 thyroiditis 10.0
26 weill-marchesani syndrome 9.9 ADAMTS10 ADAMTSL2 FBN1
27 esophageal cancer 9.9
28 tetralogy of fallot 9.9
29 tracheoesophageal fistula with or without esophageal atresia 9.9
30 tracheopathia osteoplastica 9.9
31 down syndrome 9.9
32 lung cancer 9.9
33 esophageal atresia 9.9
34 respiratory failure 9.9
35 goiter 9.9
36 relapsing polychondritis 9.9
37 olfactory groove meningioma 9.9 PGRMC1 RHNO1
38 sphenoid sinusitis 9.8 PGRMC1 RHNO1
39 body mass index quantitative trait locus 11 9.8
40 mucopolysaccharidosis, type ii 9.8
41 body mass index quantitative trait locus 9 9.8
42 body mass index quantitative trait locus 8 9.8
43 body mass index quantitative trait locus 4 9.8
44 body mass index quantitative trait locus 10 9.8
45 body mass index quantitative trait locus 7 9.8
46 wegener granulomatosis 9.8
47 body mass index quantitative trait locus 12 9.8
48 body mass index quantitative trait locus 14 9.8
49 body mass index quantitative trait locus 18 9.8
50 laryngotracheitis 9.8

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis

Symptoms & Phenotypes for Tracheal Stenosis

Drugs & Therapeutics for Tracheal Stenosis

Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4
13 Methylprednisolone Hemisuccinate Phase 4
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Prednisolone acetate Phase 4
17 Prednisolone hemisuccinate Phase 4
18 Prednisolone phosphate Phase 4
19 Protective Agents Phase 4
20
Glucosamine Approved, Investigational, Nutraceutical Phase 1, Phase 2 3416-24-8 439213
21 Anticoagulants Phase 1, Phase 2
22 Antimetabolites Phase 1, Phase 2
23 Fibrinolytic Agents Phase 1, Phase 2
24 Glucuronyl glucosamine glycan sulfate Phase 1, Phase 2
25 Hypoglycemic Agents Phase 1, Phase 2
26 Hypolipidemic Agents Phase 1, Phase 2
27 Lipid Regulating Agents Phase 1, Phase 2
28
Menthol Approved 2216-51-5 16666
29
Levobupivacaine Approved, Investigational 27262-47-1 92253
30
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
31
Dexmedetomidine Approved, Vet_approved 76631-46-4, 113775-47-6 5311068 56032 68602
32
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
33
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
34
Temazepam Approved, Investigational 846-50-4 5391
35 Anesthetics
36 Alkylating Agents
37 Anti-Bacterial Agents
38 Antibiotics, Antitubercular
39 Mitomycins
40 Nucleic Acid Synthesis Inhibitors
41 Anesthetics, Local
42 Antipruritics
43 Dermatologic Agents
44 Central Nervous System Depressants
45 Adrenergic Agents
46 Adrenergic Agonists
47 Adrenergic alpha-2 Receptor Agonists
48 Adrenergic alpha-Agonists
49 Analgesics
50 Analgesics, Non-Narcotic

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Recruiting NCT03130374 Phase 1, Phase 2
3 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Recruiting NCT01977911 Phase 1, Phase 2
5 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Active, not recruiting NCT02949414 Phase 1
6 Biodegradable Stents in the Management of Stenoses of the Large Airways Unknown status NCT02620319
7 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
8 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Completed NCT02796326
9 Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS) Completed NCT00446706
10 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
11 A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Recruiting NCT02961387
12 Study of Mitomycin-C Application in Laryngotracheal Stenosis Recruiting NCT01523275 Mitomycin -C
13 Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery Recruiting NCT02900794
14 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
15 Local Wound Infiltration for Tracheal Reconstruction Enrolling by invitation NCT02949661
16 Endotracheal Dilator to Improve Oxygenation Not yet recruiting NCT03411928
17 Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery Not yet recruiting NCT03426527 Levobupivacaine;Levobupivacaine-Dexmedetomidine
18 Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence Not yet recruiting NCT03423017
19 MRI Review of Tracheal Dimensions Terminated NCT00277953
20 Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy Terminated NCT00184925
21 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

Genetic Tests for Tracheal Stenosis

Genetic tests related to Tracheal Stenosis:

# Genetic test Affiliating Genes
1 Tracheal Stenosis 28

Anatomical Context for Tracheal Stenosis

MalaCards organs/tissues related to Tracheal Stenosis:

38
Trachea, Lung, Heart, Thyroid, B Cells, Cortex, T Cells

Publications for Tracheal Stenosis

Articles related to Tracheal Stenosis:

(show top 50) (show all 640)
# Title Authors Year
1
Ventilation strategy and anesthesia management in patients with severe tracheal stenosis undergoing urgent tracheal stenting. ( 29315465 )
2018
2
High-flow nasal cannula oxygenation during interventional bronchoscopy in a patient with severe tracheal stenosis. ( 29428824 )
2018
3
Two Bronchogenic Cysts Causing Tracheal Stenosis in an Infant. ( 29099998 )
2018
4
Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent. ( 29093400 )
2018
5
Bronchial Mismatch as a Predictor of Respiratory Failure After Congenital Tracheal Stenosis Repair. ( 29397926 )
2018
6
Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. ( 29447825 )
2018
7
Tracheal A-frame Deformity: A Challenging Variant of Tracheal Stenosis. ( 29394162 )
2018
8
Intubation in two patients with difficult airway management and tracheal stenosis after tracheostomy in thoracic surgery. ( 29429553 )
2018
9
Extended resection of the trachea in a patient with cicatricial tracheal stenosis after tracheostomy complicated with esophageal-tracheal fistula and extensive defect of the frontal tracheal wall. ( 28515752 )
2017
10
An Overview of Tracheal Stenosis Research Trends and Hot Topics. ( 29048922 )
2017
11
A foreign body mimicking tracheal stenosis. ( 28747947 )
2017
12
Changes in Tracheostomy- and Intubation-Related Tracheal Stenosis: Implications for Surgery. ( 28619544 )
2017
13
Significant Amelioration of Tracheal Stenosis following Lenvatinib in a Patient Who Has Anaplastic Thyroid Carcinoma with Bronchomediastinal Infiltration: A Case Report. ( 28413394 )
2017
14
The "Hitch Stitch": An Effective Method of Preventing Migration in High Tracheal Stenosis. ( 27988514 )
2017
15
Clinical implications of differentiating between types of post-tracheostomy tracheal stenosis. ( 29268510 )
2017
16
Clinical outcomes after tracheoplasty in patients with congenital tracheal stenosis in 1997-2014. ( 29370890 )
2017
17
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
18
A canine model of tracheal stenosis induced by cuffed endotracheal intubation. ( 28349955 )
2017
19
A new technique for treatment of tracheal stenosis. ( 28374983 )
2017
20
To do or not to do? The management dilemma of congenital tracheal stenosis in the setting of the ring-sling complex. ( 29312686 )
2017
21
Maintenance of balance between airway pressure and intracranial pressure in a patient with tracheal stenosis undergoing craniotomy: a case report. ( 28017177 )
2017
22
Left pulmonary artery sling and congenital tracheal stenosis: to slide or not to slide? ( 29312682 )
2017
23
Innovative use of a Montgomery cannula in the bronchoscopic management of tracheal stenosis and failed tracheostomy decannulation. ( 28794964 )
2017
24
An Adolescent with Dyspnea and Cough. A Case of Congenital Tracheal Stenosis. ( 28683205 )
2017
25
Tracheal stenosis in a paediatric patient with severe haemophilia A and FVIII inhibitors. ( 28925572 )
2017
26
Concentric photothermal coagulation with basket-integrated optical device for treatment of tracheal stenosis. ( 28731623 )
2017
27
Usefulness of 3D Printing to Manage Complex Tracheal Stenosis. ( 28323743 )
2017
28
Management of congenital tracheal stenosis in the neonatal period. ( 28801794 )
2017
29
Operative or non-operative treatment of congenital tracheal stenosis: is there something new? ( 29312681 )
2017
30
The role of adjunctive procedures in reducing postoperative tracheobronchial obstruction in single lung patients with congenital tracheal stenosis undergoing slide tracheoplasty. ( 28185629 )
2017
31
Comparison between traditional and small-diameter tube-assisted bronchoscopic balloon dilatation in the treatment of benign tracheal stenosis. ( 28296266 )
2017
32
Topical mitomycin C application for the control of recurrent tracheal stenosis even after tracheal surgery. ( 29297460 )
2017
33
Bedside ultrasonography to guide intubation for a patient with an unexpected cervical tracheal stenosis: a case report. ( 28220484 )
2017
34
Item Selection and Content Validity of the Risk Factors of Post-Intubation Tracheal Stenosis Observation Questionnaire for ICU-Admitted Patients. ( 28638421 )
2017
35
Jet ventilation in obese patients undergoing airway surgery for subglottic and tracheal stenosis. ( 29288493 )
2017
36
Stent-induced tracheal stenosis can be predicted by IL-8 expression in rabbits. ( 27873304 )
2017
37
Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome. ( 28363712 )
2017
38
The Relationship between Body Mass, Tracheal Diameter, Endotracheal Tube Size, and Tracheal Stenosis. ( 27930416 )
2017
39
Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases. ( 28869225 )
2017
40
Surgical treatment of postintubation tracheal stenosis: A retrospective 22-patient series from a single center. ( 28412038 )
2017
41
Right Lung Agenesis with Tracheal Stenosis due to Complete Tracheal Rings and Postpneumonectomy Like Syndrome Treated with Tissue Expander Placement. ( 27882259 )
2016
42
Management of Life-Threatening Tracheal Stenosis and Tracheomalacia in Patients with Mucopolysaccharidoses. ( 27450368 )
2016
43
Surgical intervention strategies for congenital tracheal stenosis associated with a tracheal bronchus based on the location of stenosis. ( 27457232 )
2016
44
Recurrent membranous tracheal stenosis with a diverticulum in a 9-year-old boy. Not all that wheezes is asthma. ( 26927469 )
2016
45
Three-dimensional reconstruction of trachea using computed tomography imaging as therapy for tracheal stenosis in infants. ( 27282237 )
2016
46
Bronchoscopic Treatment in the Management of Benign Tracheal Stenosis: Choices for Simple and Complex Tracheal Stenosis. ( 26704411 )
2016
47
Awake emergency endotracheal intubation using sheath-assisted technique for patients having malignant tracheal stenosis under fluoroscopy guidance: a retrospective study. ( 27400991 )
2016
48
Recurred Post-intubation Tracheal Stenosis Treated with Bronchoscopic Cryotherapy. ( 27853078 )
2016
49
Subglottic tracheal stenosis. ( 26981264 )
2016
50
Awareness Regarding Application of Endotracheal Tube (ETT) Cuff Pressure Measuring Gauge in Anesthesia Practice; ACritical Step to Avoid Postintubation Tracheal Stenosis in Critically ill Patients on Prolonged Mechanical Ventilator. ( 27504563 )
2016

Variations for Tracheal Stenosis

Expression for Tracheal Stenosis

Search GEO for disease gene expression data for Tracheal Stenosis.

Pathways for Tracheal Stenosis

Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.5 ADAMTS10 ADAMTSL2

GO Terms for Tracheal Stenosis

Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.13 ADAMTS10 ADAMTSL2 FBN1
2 microfibril GO:0001527 8.62 ADAMTS10 FBN1

Molecular functions related to Tracheal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ADAMTS10 ADAMTSL2 FBN1 IYD PGRMC1 POC1A

Sources for Tracheal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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