MCID: TRC005
MIFTS: 36

Tracheal Stenosis

Categories: Respiratory diseases, Rare diseases

Aliases & Classifications for Tracheal Stenosis

MalaCards integrated aliases for Tracheal Stenosis:

Name: Tracheal Stenosis 12 29 42 14 69
Stenosis of Trachea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3227
MeSH 42 D014135
NCIt 47 C78646
SNOMED-CT 64 11296007
UMLS 69 C0040583

Summaries for Tracheal Stenosis

MalaCards based summary : Tracheal Stenosis, also known as stenosis of trachea, is related to esophageal atresia and congenital tracheal stenosis. An important gene associated with Tracheal Stenosis is ADAMTSL2 (ADAMTS Like 2), and among its related pathways/superpathways is O-glycosylation of TSR domain-containing proteins. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and heart.

Related Diseases for Tracheal Stenosis

Diseases in the Tracheal Stenosis family:

Congenital Tracheal Stenosis

Diseases related to Tracheal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 esophageal atresia 29.5 FBN1 TEF
2 congenital tracheal stenosis 12.1
3 idiopathic subglottic tracheal stenosis 12.1
4 anterior chamber cleavage disorder, cerebellar hypoplasia, hypothyroidism, and tracheal stenosis 11.9
5 geleophysic dysplasia 1 11.1
6 geleophysic dysplasia 2 11.0
7 geleophysic dwarfism 11.0
8 tracheobronchial stenosis, congenital 10.9
9 jung wolff back stahl syndrome 10.9
10 giant axonal neuropathy 10.3 ADAMTSL2 FBN1
11 congenital nervous system abnormality 10.3 SLC22A4 TEF
12 laryngitis 10.2
13 esophagitis 10.1
14 tracheomalacia 10.0
15 asthma 10.0
16 heart disease 10.0
17 tracheoesophageal fistula 10.0
18 cervicitis 10.0
19 mediastinitis 10.0
20 epiglottitis 9.9 RHNO1 SLC22A4
21 endemic typhus 9.9 ADAMTS10 ADAMTSL2 FBN1
22 aneurysm 9.9
23 burns 9.9
24 tuberculosis 9.9
25 thyroiditis 9.9
26 intraductal breast myoepitheliosis 9.9 PGRMC1 RHNO1
27 pelvic varices 9.9 RHNO1 TEF
28 lung cancer 9.8
29 esophageal cancer 9.8
30 tetralogy of fallot 9.8
31 down syndrome 9.8
32 lung agenesis 9.8
33 goiter 9.8
34 relapsing polychondritis 9.8
35 oral hairy leukoplakia 9.8 IYD SLC22A4 TEF
36 laryngotracheitis 9.7
37 lymphoma 9.7
38 respiratory failure 9.7
39 thyroid cancer 9.7
40 fibrosing mediastinitis 9.7
41 acute gonococcal epididymo-orchitis 9.7 PGRMC1 RHNO1
42 central nervous system germ cell tumor 9.6 PGRMC1 RHNO1
43 rheumatoid arthritis 9.6
44 systemic lupus erythematosus 9.6
45 mowat-wilson syndrome 9.6
46 obesity 9.6
47 wegener granulomatosis 9.6
48 pfeiffer syndrome 9.6
49 anorexia nervosa 9.6
50 tracheopathia osteoplastica 9.6

Graphical network of the top 20 diseases related to Tracheal Stenosis:



Diseases related to Tracheal Stenosis

Symptoms & Phenotypes for Tracheal Stenosis

Drugs & Therapeutics for Tracheal Stenosis

Drugs for Tracheal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4
13 Methylprednisolone Hemisuccinate Phase 4
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Prednisolone acetate Phase 4
17 Prednisolone hemisuccinate Phase 4
18 Prednisolone phosphate Phase 4
19 Protective Agents Phase 4
20
Glucosamine Approved, Nutraceutical Phase 1, Phase 2 3416-24-8 439213
21
Iodine Investigational Phase 2 7553-56-2 807
22 cadexomer iodine Phase 2
23 Anticoagulants Phase 1, Phase 2
24 Antimetabolites Phase 1, Phase 2
25 Fibrinolytic Agents Phase 1, Phase 2
26 Glucuronyl glucosamine glycan sulfate Phase 1, Phase 2
27 Hypoglycemic Agents Phase 1, Phase 2
28 Hypolipidemic Agents Phase 1, Phase 2
29 Lipid Regulating Agents Phase 1, Phase 2
30
Menthol Approved 2216-51-5 16666
31
Levobupivacaine Approved 27262-47-1 92253
32 Alkylating Agents
33 Anti-Bacterial Agents
34 Antibiotics, Antitubercular
35 Mitomycins
36 Nucleic Acid Synthesis Inhibitors
37 Anesthetics
38 Anesthetics, Local
39 Antipruritics
40 Dermatologic Agents
41 Central Nervous System Depressants
42 Calamus Nutraceutical

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients Completed NCT02855502 Phase 4 Prednisolone;Placebo
2 A Trail of a Novel Tracheal Radioactive Stent for the Malignant Airway Obstruction Unknown status NCT02565927 Phase 2 Iodine-125 seeds
3 Airway and/or Pulmonary Vessels Transplantation Recruiting NCT01331863 Phase 1, Phase 2
4 Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants Recruiting NCT01977911 Phase 1, Phase 2
5 Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells Enrolling by invitation NCT03130374 Phase 1, Phase 2
6 A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells Active, not recruiting NCT02949414 Phase 1
7 Management of Complex Airway Stenoses With Dedicated Tailored Stents Wrought by 3D Computer-assisted Conception Not yet recruiting NCT02889029 Phase 1
8 Comparison of Intubation Conditions Between the Gliderite and the S-Guide Unknown status NCT02519647
9 Matrix Biology of Tracheobronchomalacia and Tracheal Stenosis Completed NCT00705848
10 Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS) Completed NCT00446706
11 Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing Completed NCT01006200
12 "Cuffed Versus Uncuffed Tracheal Tubes in Small Children" Completed NCT00221377
13 A Clinical Trial on Effectiveness and Safety of Hydrogen Generator to Treat Dyspnea for the Patients With Tracheal Stenosis: A Randomized, Double-blind and Single-center Clinical Study Recruiting NCT02961387
14 Modified Endotracheal Balloon Dilator to Improve Patient Oxygenation and Allow Ventilation During Airway Procedures Recruiting NCT02796326
15 Study of Mitomycin-C Application in Laryngotracheal Stenosis Recruiting NCT01523275 Mitomycin -C
16 Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery Recruiting NCT02900794
17 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Recruiting NCT02481817
18 Endoscopic Evaluation of the Paediatric Airway After Prior Prolonged (>24 h) Tracheal Intubation Recruiting NCT02350933
19 Cuffed Versus Uncuffed Tracheal Tubes in PICU (PICU-BG-TT Study) Recruiting NCT03129893
20 Biodegradable Stents in the Management of Stenoses of the Large Airways Active, not recruiting NCT02620319
21 trūFreeze® Spray Cryotherapy Patient Registry Active, not recruiting NCT01802203
22 Local Wound Infiltration for Tracheal Reconstruction Enrolling by invitation NCT02949661
23 MRI Review of Tracheal Dimensions Terminated NCT00277953
24 Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy Terminated NCT00184925
25 Office-based Radial Expansion Balloon Dilation of the Esophagus and Trachea Withdrawn NCT00583960

Search NIH Clinical Center for Tracheal Stenosis

Cochrane evidence based reviews: tracheal stenosis

Genetic Tests for Tracheal Stenosis

Genetic tests related to Tracheal Stenosis:

id Genetic test Affiliating Genes
1 Tracheal Stenosis 29

Anatomical Context for Tracheal Stenosis

MalaCards organs/tissues related to Tracheal Stenosis:

39
Trachea, Lung, Heart, Thyroid, T Cells, B Cells, Cortex

Publications for Tracheal Stenosis

Articles related to Tracheal Stenosis:

(show top 50) (show all 624)
id Title Authors Year
1
Bedside ultrasonography to guide intubation for a patient with an unexpected cervical tracheal stenosis: a case report. ( 28220484 )
2017
2
Innovative use of a Montgomery cannula in the bronchoscopic management of tracheal stenosis and failed tracheostomy decannulation. ( 28794964 )
2017
3
Surgical treatment of postintubation tracheal stenosis: A retrospective 22-patient series from a single center. ( 28412038 )
2017
4
The role of adjunctive procedures in reducing postoperative tracheobronchial obstruction in single lung patients with congenital tracheal stenosis undergoing slide tracheoplasty. ( 28185629 )
2017
5
Item Selection and Content Validity of the Risk Factors of Post-Intubation Tracheal Stenosis Observation Questionnaire for ICU-Admitted Patients. ( 28638421 )
2017
6
Tracheal stenosis in a paediatric patient with severe haemophilia A and FVIII inhibitors. ( 28925572 )
2017
7
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
8
Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome. ( 28363712 )
2017
9
Stent-induced tracheal stenosis can be predicted by IL-8 expression in rabbits. ( 27873304 )
2017
10
A canine model of tracheal stenosis induced by cuffed endotracheal intubation. ( 28349955 )
2017
11
A new technique for treatment of tracheal stenosis. ( 28374983 )
2017
12
Changes in Tracheostomy- and Intubation-Related Tracheal Stenosis: Implications for Surgery. ( 28619544 )
2017
13
Maintenance of balance between airway pressure and intracranial pressure in a patient with tracheal stenosis undergoing craniotomy: a case report. ( 28017177 )
2017
14
An Adolescent with Dyspnea and Cough. A Case of Congenital Tracheal Stenosis. ( 28683205 )
2017
15
The "Hitch Stitch": An Effective Method of Preventing Migration in High Tracheal Stenosis. ( 27988514 )
2017
16
Management of congenital tracheal stenosis in the neonatal period. ( 28801794 )
2017
17
Usefulness of 3D Printing to Manage Complex Tracheal Stenosis. ( 28323743 )
2017
18
Resection and anastomosis for benign tracheal stenosis: Single institution experience of 18 cases. ( 28869225 )
2017
19
A foreign body mimicking tracheal stenosis. ( 28747947 )
2017
20
Concentric photothermal coagulation with basket-integrated optical device for treatment of tracheal stenosis. ( 28731623 )
2017
21
Extended resection of the trachea in a patient with cicatricial tracheal stenosis after tracheostomy complicated with esophageal-tracheal fistula and extensive defect of the frontal tracheal wall. ( 28515752 )
2017
22
Significant Amelioration of Tracheal Stenosis following Lenvatinib in a Patient Who Has Anaplastic Thyroid Carcinoma with Bronchomediastinal Infiltration: A Case Report. ( 28413394 )
2017
23
Comparison between traditional and small-diameter tube-assisted bronchoscopic balloon dilatation in the treatment of benign tracheal stenosis. ( 28296266 )
2017
24
The Relationship between Body Mass, Tracheal Diameter, Endotracheal Tube Size, and Tracheal Stenosis. ( 27930416 )
2017
25
Acquired tracheoesophageal fistula with undiagnosed tracheal stenosis: A simple innovation to avoid tracheostomy! ( 27942069 )
2016
26
Acute and Progressive Tracheal Stenosis after Proton Beam Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer. ( 27108695 )
2016
27
Bridge to recovery using extracorporeal membrane oxygenation for critical tracheal stenosis complicating refractory bronchospasm. ( 27477835 )
2016
28
Effects of artificial tracheal fixation on tracheal epithelial regeneration and prevention of tracheal stenosis. ( 27885873 )
2016
29
Subglottic tracheal stenosis. ( 26981264 )
2016
30
Evolution of Surgical Approaches in the Management of Congenital Tracheal Stenosis: Single-Center Experience. ( 26714989 )
2016
31
Clinical significance of differentiating post-intubation and post-tracheostomy tracheal stenosis. ( 27766714 )
2016
32
Awareness Regarding Application of Endotracheal Tube (ETT) Cuff Pressure Measuring Gauge in Anesthesia Practice; ACritical Step to Avoid Postintubation Tracheal Stenosis in Critically ill Patients on Prolonged Mechanical Ventilator. ( 27504563 )
2016
33
Emergency management for congenital tracheal stenosis with endoluminal stenting in pediatric intensive care units. ( 27126522 )
2016
34
Failed intubation of an unanticipated postintubation tracheal stenosis: a case report. ( 27064682 )
2016
35
Awake emergency endotracheal intubation using sheath-assisted technique for patients having malignant tracheal stenosis under fluoroscopy guidance: a retrospective study. ( 27400991 )
2016
36
Treatment of Benign Tracheal Stenosis Using Endoluminal Spray Cryotherapy. ( 27532803 )
2016
37
First-line tracheal resection and primary anastomosis for postintubation tracheal stenosis. ( 27138847 )
2016
38
Benign tracheal stenosis a case report and up to date management. ( 27999785 )
2016
39
A new endoscopic hand drill for management of tracheal stenosis. ( 27006182 )
2016
40
Surgical intervention strategies for congenital tracheal stenosis associated with a tracheal bronchus based on the location of stenosis. ( 27457232 )
2016
41
Complete subglottic tracheal stenosis managed with rigid bronchoscopy and T-tube placement. ( 27890997 )
2016
42
The Role of Systemic Steroids in Postintubation Tracheal Stenosis: A Randomized Clinical Trial. ( 27476818 )
2016
43
Recurrent Tracheal Stenosis: A Novel Presentation of Silicosis. ( 27388408 )
2016
44
Bronchoscopy in Benign Tracheal Stenosis. ( 27847049 )
2016
45
Recurred Post-intubation Tracheal Stenosis Treated with Bronchoscopic Cryotherapy. ( 27853078 )
2016
46
Biodegradable polydioxanone stent as a new treatment strategy for tracheal stenosis in a rabbit model. ( 27670964 )
2016
47
Bronchoscopic Treatment in the Management of Benign Tracheal Stenosis: Choices for Simple and Complex Tracheal Stenosis. ( 26704411 )
2016
48
TGF-I^ antagonist attenuates fibrosis but not luminal narrowing in experimental tracheal stenosis. ( 27859294 )
2016
49
Bronchoscopic balloon dilatation for tuberculosis-associated tracheal stenosis: a two case report and a literature review. ( 26825956 )
2016
50
Anterograde catheterization of severe tracheal stenosis as a difficult airway management option, followed by emergent tracheostomy (a case report). ( 27114241 )
2016

Variations for Tracheal Stenosis

Expression for Tracheal Stenosis

Search GEO for disease gene expression data for Tracheal Stenosis.

Pathways for Tracheal Stenosis

Pathways related to Tracheal Stenosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.5 ADAMTS10 ADAMTSL2

GO Terms for Tracheal Stenosis

Cellular components related to Tracheal Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.13 ADAMTS10 ADAMTSL2 FBN1
2 microfibril GO:0001527 8.62 ADAMTS10 FBN1

Molecular functions related to Tracheal Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ADAMTS10 ADAMTSL2 FBN1 IYD PGRMC1 POC1A
2 metalloendopeptidase activity GO:0004222 8.96 ADAMTS10 ADAMTSL2

Sources for Tracheal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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