MCID: TRC040
MIFTS: 40

Tracheoesophageal Fistula malady

Category: Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

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Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 45 47 24
Tracheoesophageal Fistula with or Without Esophageal Atresia 45
 
Te Fistula 45
Tef 45

Classifications:



Summaries for Tracheoesophageal Fistula

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NIH Rare Diseases:45 Tracheoesophageal fistula (tef) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). the esophagus and trachea run next to each other through the chest cavity. the esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. tef can lead to severe and fatal lung complications. saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. most affected people are diagnosed immediately after birth or during infancy. symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. tef may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). in many cases the cause is unknown but it has been associated with some chromosome disorders. in some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. treatment includes immediate surgical repair with survival rates of almost 100%. last updated: 7/8/2015

MalaCards based summary: Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to tracheoesophageal fistula symphalangism and hypoplastic left heart syndrome, and has symptoms including tracheoesophageal fistulaand esophageal atresia. An important gene associated with Tracheoesophageal Fistula is SHH (Sonic Hedgehog). Affiliated tissues include trachea, lung and heart, and related mouse phenotypes are taste/olfaction and integument.

Wikipedia:68 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1tracheoesophageal fistula symphalangism29.9CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
2hypoplastic left heart syndrome28.8PTEN, ZIC3
3esophageal atresia/tracheoesophageal fistula12.5
4pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula12.2
5feingold syndrome11.4
6feingold syndrome 211.1
7blaichman syndrome11.1
8esophagitis11.0
9esophageal atresia10.9
10vacterl association10.7
11vater association with macrocephaly and ventriculomegaly10.3
12vacterl association, x-linked10.3
13laryngitis10.3
14duodenitis10.3
15lymphoma10.2
16tracheomalacia10.2
17duodenal atresia10.2
18esophageal cancer10.2
19tracheal stenosis10.2
20congenital diaphragmatic hernia10.1
21tracheal agenesis10.1
22mitchell-riley syndrome10.1
23fanconi anemia, complementation group b10.1
24tryptophan hydroxylase deficiency10.1HOXD13, SHH
25lung cancer10.1
26hypertrophic pyloric stenosis10.1
27pyloric stenosis10.1
28cervicitis10.1
29right aortic arch10.1
30gastroesophageal reflux10.0
31imperforate anus10.0
32respiratory failure10.0
33thyroiditis10.0
34mediastinitis10.0
35laryngeal cleft10.0
36aspiration pneumonia9.9
37dermatomyositis9.9
38microcephaly9.9
39heart disease9.9
40congenital heart disease9.9
41pneumonia9.9
42situs inversus9.9
43achalasia9.9
44congenital tracheal stenosis9.9
45tricuspid atresia9.9
46dysphagia9.9
47bone deterioration disease9.9HOXD13, NOG
48nontoxic goiter9.8PTEN, SHH
49ovary leiomyosarcoma9.8PTEN, ZIC3
50gummatous syphilis9.8HOXD13, NOG

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms for Tracheoesophageal Fistula

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HPO human phenotypes related to Tracheoesophageal Fistula:

id Description Frequency HPO Source Accession
1 tracheoesophageal fistula HP:0002575
2 esophageal atresia HP:0002032

Drugs & Therapeutics for Tracheoesophageal Fistula

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Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1threonineNutraceutical17

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endoscopic Closure of Tracheoesophageal Fistulas With Occluder DeviceTerminatedNCT01153061Phase 4
2Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesRecruitingNCT01467245
3Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula RepairRecruitingNCT01287312
4A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 MonthsEnrolling by invitationNCT02364843
5Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

33
Trachea, Lung, Heart, Thyroid, Kidney, B cells, T cells

Animal Models for Tracheoesophageal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2NOG, PTEN, SHH
2MP:00107718.7HOXD13, NOG, PTEN, SHH
3MP:00053828.6CHD7, NOG, SHH, ZIC3
4MP:00028738.6NOG, PTEN, SHH, ZIC3
5MP:00053678.5HOXD13, NOG, PTEN, SHH
6MP:00053798.2CHD7, HOXD13, NOG, PTEN, SHH
7MP:00053778.2CHD7, NOG, SHH, ZIC3
8MP:00053888.0CHD7, NOG, PTEN, SHH, ZIC3
9MP:00053697.9CHD7, HOXD13, NOG, PTEN, SHH
10MP:00036317.9CHD7, NOG, PTEN, SHH, ZIC3
11MP:00053847.9CHD7, NOG, PTEN, SHH, ZIC3
12MP:00053807.6CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
13MP:00053857.5CHD7, NOG, PTEN, SHH, ZIC3
14MP:00053717.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
15MP:00053897.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
16MP:00053917.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
17MP:00053817.4CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
18MP:00107687.2CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
19MP:00053787.1CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
20MP:00053907.1CHD7, HOXD13, NOG, PTEN, SHH, ZIC3

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Late presenting iatrogenic tracheoesophageal fistula. (26936836)
2016
2
Esophageal Dysmotility Is Present Before Surgery in Isolated Tracheoesophageal Fistula. (25493344)
2015
3
Endoscopic closure of tracheoesophageal fistula with submucosal dissection and a biosynthetic mesh. (26115391)
2015
4
A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. (25783403)
2015
5
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
6
VACTERL (Vertebral Defects, Anal Atresia, Tracheoesophageal Fistula withA Esophageal Atresia, Cardiac Defects, Renal and Limb Anomalies) Association: Disease Spectrum in 25 Patients Ascertained for Their UpperA Limb Involvement. (24210691)
2013
7
A case series study of therapeutic implications of type IIIb4: a rare variant of esophageal atresia and distal tracheoesophageal fistula. (23895955)
2013
8
Video: argon plasma coagulator in a 2-month-old child with tracheoesophageal fistula. (22476825)
2012
9
Thoracoscopic treatment of congenital esophageal stenosis in combination with H-type tracheoesophageal fistula. (22901927)
2012
10
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
11
Selective bilateral bronchial intubation for large, acquired tracheoesophageal fistula. (22474805)
2012
12
Congenital tracheoesophageal fistula. (22272674)
2012
13
Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association. (22639458)
2012
14
Analysis of saliva pepsin level in patients with tracheoesophageal fistula and voice prosthesis complications. (23397763)
2012
15
Usefulness of dextranomer/hyaluronic acid copolymer in bronchoscopic treatment of recurrent tracheoesophageal fistula in children. (21782257)
2011
16
Choanal atresia associated with tracheoesophageal fistula: the spectrum of carbimazole embryopathy. (21807695)
2011
17
Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer. (21769294)
2011
18
Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistula. (20112230)
2010
19
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
20
Diagnosis of esophageal atresia with tracheoesophageal fistula: is there a need for gastrointestinal contrast? (20056230)
2010
21
Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. (20054858)
2010
22
Esophageal atresia/tracheoesophageal fistula in very low-birth-weight neonates: improved outcomes with staged repair. (20006009)
2009
23
Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema. (19908119)
2009
24
Sternohyoid muscle flap interposition in the treatment of an acquired tracheoesophageal fistula. (19260113)
2009
25
Longitudinal follow-up of bronchial inflammation, respiratory symptoms, and pulmonary function in adolescents after repair of esophageal atresia with tracheoesophageal fistula. (18534205)
2008
26
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
27
Severe stridor following the repair of H-type tracheoesophageal fistula in an 11 month infant. (19235526)
2008
28
Feingold syndome: a rare but important cause of syndromic tracheoesophageal fistula. (17848225)
2007
29
An unknown second tracheoesophageal fistula: a rare cause of postoperative respiratory failure. (16618307)
2006
30
Anesthetic management of tracheoesophageal fistula repair in a newborn with hypoplastic left heart syndrome. (16677272)
2006
31
High-grade congenital esophageal stenosis owing to a membranous diaphragm with tracheoesophageal fistula. (16226967)
2005
32
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
33
Infant with esophageal atresia and tracheoesophageal fistula associated with DiGeorge syndrome. (15303257)
2004
34
An endotracheal/tracheostomy tube technique for the emergency management of a midtracheal tracheoesophageal fistula. (12819001)
2003
35
Tracheoesophageal fistula caused by a self-expanding esophageal stent. (10215238)
1999
36
Simplifying the Waterston's stratification of infants with tracheoesophageal fistula. (10515532)
1999
37
Successful long-term endoscopic closure of a recurrent tracheoesophageal fistula with fibrin glue in a child. (10402124)
1999
38
Split pectoralis major flap for massive tracheoesophageal fistula. (9419118)
1997
39
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
40
Esophageal duplication cyst with esophageal web and tracheoesophageal fistula. (8811570)
1996
41
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
42
Use of an intratracheal silicone prosthesis (Dumon type) for the treatment of tracheoesophageal fistula due to advanced lung cancer. (8931224)
1996
43
Bronchoscopy and occlusion of tracheoesophageal fistula. (8638821)
1996
44
Radiology rounds. Tracheoesophageal fistula. (7787487)
1995
45
Simple technique for proximal pouch mobilization and circular myotomy in cases of esophageal atresia with tracheoesophageal fistula. (7807338)
1994
46
Recurrent tracheoesophageal fistula treated with fibrin glue. (7877030)
1994
47
Tracheoesophageal fistula caused by mycobacterial tuberculosis adenopathy. (8512414)
1993
48
Esophageal atresia and tracheoesophageal fistula in children. (8374655)
1993
49
Esophageal Atresia/Tracheoesophageal Fistula Overview (20301753)
1993
50

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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GO Terms for genes affiliated with Tracheoesophageal Fistula

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Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:006105310.1NOG, SHH
2forebrain developmentGO:003090010.1NOG, SHH
3embryonic skeletal system developmentGO:004870610.1NOG, SHH
4negative regulation of cell differentiationGO:004559610.1NOG, SHH
5dorsal/ventral pattern formationGO:000995310.1NOG, SHH
6camera-type eye developmentGO:004301010.0CHD7, SHH
7embryonic hindlimb morphogenesisGO:003511610.0CHD7, SHH
8determination of left/right symmetryGO:00073689.8SHH, ZIC3
9negative regulation of canonical Wnt signaling pathwayGO:00900909.8NOG, SHH
10negative regulation of gene expressionGO:00106299.8NOG, SHH
11skeletal system developmentGO:00015019.8CHD7, NOG
12limb developmentGO:00601739.6CHD7, NOG, SHH
13embryonic digit morphogenesisGO:00427339.6HOXD13, NOG, SHH
14canonical Wnt signaling pathwayGO:00600709.6PTEN, SHH
15palate developmentGO:00600219.4CHD7, SHH
16anterior/posterior pattern specificationGO:00099529.4HOXD13, SHH, ZIC3
17pattern specification processGO:00073899.3NOG, SHH, ZIC3
18anatomical structure formation involved in morphogenesisGO:00486469.3NOG, SHH
19locomotory behaviorGO:00076269.1CHD7, PTEN
20negative regulation of cell migrationGO:00303368.9NOG, PTEN, SHH
21central nervous system developmentGO:00074178.7CHD7, NOG, PTEN, SHH
22positive regulation of transcription from RNA polymerase II promoterGO:00459448.5HOXD13, NOG, SHH, ZIC3

Sources for Tracheoesophageal Fistula

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet