TEF
MCID: TRC040
MIFTS: 45

Tracheoesophageal Fistula (TEF) malady

Category: Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

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Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 48 27 50
Tracheoesophageal Fistula with or Without Esophageal Atresia 48
 
Te Fistula 48
Tef 48

Classifications:



Summaries for Tracheoesophageal Fistula

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NIH Rare Diseases:48 Tracheoesophageal fistula (tef) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). the esophagus and trachea run next to each other through the chest cavity. the esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. tef can lead to severe and fatal lung complications. saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. most affected people are diagnosed immediately after birth or during infancy. symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. tef may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). in many cases the cause is unknown but it has been associated with some chromosome disorders. in some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. treatment includes immediate surgical repair with survival rates of almost 100%. last updated: 7/8/2015

MalaCards based summary: Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to esophageal atresia/tracheoesophageal fistula and pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is SHH (Sonic Hedgehog), and among its related pathways are Differentiation Pathway and Tgif disruption of Shh signaling. Affiliated tissues include trachea, lung and thyroid, and related mouse phenotypes are taste/olfaction and craniofacial.

Wikipedia:71 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal atresia/tracheoesophageal fistula12.5
2pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula12.0
3tracheoesophageal fistula with or without esophageal atresia12.0
4tracheoesophageal fistula symphalangism12.0
5feingold syndrome11.3
6vater association with macrocephaly and ventriculomegaly11.2
7vacterl association, x-linked11.2
8vater/vacterl association11.2
9mitchell-riley syndrome11.0
10fanconi anemia, complementation group b11.0
11feingold syndrome 211.0
12esophagitis10.9
13esophageal atresia10.8
14laryngitis10.1
15duodenitis10.1
16pulmonary atresia with intact ventricular septum10.1CHD7, SHH
17anosmia, isolated congenital10.1GLI3, SHH
18duodenal atresia10.1
19lymphoma10.1
20tracheomalacia10.1
21tracheal stenosis10.1
22polydactyly, postaxial, types a1 and b10.1GLI3, SHH
23extragonadal germ cell cancer10.1GLI3, SHH
24esophageal cancer10.1
25breasts and/or nipples, aplasia or hypoplasia of, 210.0GLI3, SHH
26cervicitis10.0
27congenital diaphragmatic hernia10.0
28tracheal agenesis10.0
29aica-ribosiduria due to atic deficiency10.0GLI3, NOG
30hypoparathyroidism10.0GLI3, SHH
31horner's syndrome10.0GLI3, SHH
32t cell immunodeficiency primary10.0GLI3, NOG
33lung cancer10.0
34hypertrophic pyloric stenosis10.0
35pyloric stenosis10.0
36mediastinitis10.0
37right aortic arch10.0
38bone structure disease9.9GLI3, NOG
39glanders9.9FANCI, FANCL
40gastroesophageal reflux9.9
41imperforate anus9.9
42respiratory failure9.9
43thyroiditis9.9
44laryngeal cleft9.9
45fibrous dysplasia9.9GLI3, SHH
46atrophy of testis9.9GLI3, NOG
47aspergillosis9.8
48tricuspid atresia9.8
49aspiration pneumonia9.8
50dermatomyositis9.8

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms & Phenotypes for Tracheoesophageal Fistula

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

41 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.7GLI3, NOG, SHH
2MP:00053829.3CHD7, GLI3, NOG, SHH
3MP:00053819.3CHD7, GLI3, NOG, SHH
4MP:00053779.3CHD7, GLI3, NOG, SHH
5MP:00053719.3CHD7, GLI3, NOG, SHH
6MP:00053889.2CHD7, GLI3, NOG, SHH
7MP:00053848.8CHD7, FANCL, GLI3, NOG, SHH
8MP:00053808.8CHD7, FANCL, GLI3, NOG, SHH
9MP:00053798.8CHD7, FANCL, GLI3, NOG, SHH
10MP:00053898.7CHD7, FANCL, GLI3, NOG, SHH
11MP:00053908.7CHD7, FANCL, GLI3, NOG, SHH
12MP:00053918.5CHD7, GLI3, NOG, SHH
13MP:00107687.9CHD7, FANCI, FANCL, GLI3, NOG, SHH

Drugs & Therapeutics for Tracheoesophageal Fistula

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Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1threonineNutraceutical22

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endoscopic Closure of Tracheoesophageal Fistulas With Occluder DeviceTerminatedNCT01153061Phase 4
2Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesUnknown statusNCT01467245
3Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula RepairUnknown statusNCT01287312
4Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal FistulaCompletedNCT03026491
5National Register of Oesophageal AtresiaRecruitingNCT02883725
6Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772
7A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 MonthsEnrolling by invitationNCT02364843

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Genetic tests related to Tracheoesophageal Fistula:

id Genetic test Affiliating Genes
1 Tracheoesophageal Fistula27

Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

36
Trachea, Lung, Thyroid, Colon, Bone, Heart, Testes

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
Oesophageal atresia with no distal tracheoesophageal fistula: Management and outcomes from a population-based cohort. (27894760)
2017
2
Esophageal Atresia with or without Tracheoesophageal Fistula (EA/TEF): Association of Different EA/TEF Subtypes with Specific Co-occurring Congenital Anomalies and Implications for Diagnostic Workup. (28061520)
2017
3
Ineffective Ventilation in A Neonate with A Large Pre-Carinal Tracheoesophageal Fistula and Bilateral Pneumonitis-Microcuff Endotracheal Tube to Our Rescue! (28083500)
2017
4
Preliminary Study of Video-Based Pediatric Endoscopic Surgical Skill Assessment Using a Neonatal Esophageal Atresia/Tracheoesophageal Fistula Model. (27858521)
2017
5
Congenital bilateral syngnathia and tracheoesophageal fistula: A rare presentation. (27994431)
2016
6
Dual Use of Fiberoptic Bronchoscope in TracheoEsophageal Fistula. (28043317)
2016
7
Spontaneous Resolution of a Tracheoesophageal Fistula Caused by Button Battery Ingestion. (27195748)
2016
8
Esophageal atresia with tracheoesophageal fistula in a patient with 7q35-36.3 deletion including SHH gene. (27614115)
2016
9
Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula. (27993359)
2016
10
Evaluation of the intraoperative risk factors for esophageal anastomotic complications after primary repair of esophageal atresia with tracheoesophageal fistula. (27461430)
2016
11
Tracheoesophageal fistula repair in a neonate with tetralogy of Fallot: An anesthetic challenge. (27625509)
2016
12
Tracheoesophageal fistula induced by invasive pulmonary aspergillosis. (27761449)
2016
13
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: Basics of technique and its nuances. (27365905)
2016
14
Thoracoscopic Esophageal Atresia with Tracheoesophageal Fistula Repair: The First Iranian Group Report, Passing the Learning Curve. (27471677)
2016
15
Accuracy of prenatal detection of tracheoesophageal fistula and oesophageal atresia. (26932255)
2016
16
Presentation of H-Type Tracheoesophageal Fistula in Two Adolescents: Delayed Diagnosis. (27324122)
2016
17
Tracheoesophageal fistula. (27301604)
2016
18
The use of a sternothyroid muscle flap to prevent the re-recurrence of a recurrent tracheoesophageal fistula found 10A years after the primary repair. (27589983)
2016
19
Weekday vs. weekend repair of esophageal atresia and tracheoesophageal fistula. (26932247)
2016
20
Late Complication of Esophageal Atresia/Tracheoesophageal Fistula Repair. (27139297)
2016
21
Late presenting iatrogenic tracheoesophageal fistula. (26936836)
2016
22
Left thoracoscopic two-stage repair of tracheoesophageal fistula with a right aortic arch and a vascular ring. (27143697)
2016
23
Validation of an inanimate low cost model for training minimal invasive surgery (MIS) of esophageal atresia with tracheoesophageal fistula (AE/TEF) repair. (27530889)
2016
24
Swallowing Dysfunction and Quality of Life in Adults With Surgically Corrected Esophageal Atresia/Tracheoesophageal Fistula as Infants: Forty Years of Follow-up. (27607100)
2016
25
Acquired tracheoesophageal fistula with undiagnosed tracheal stenosis: A simple innovation to avoid tracheostomy! (27942069)
2016
26
Assessment of Clinical Symptoms and Multichannel Intraluminal Impedance and pH Monitoring in Children After Thoracoscopic Repair of Esophageal Atresia and Distal Tracheoesophageal Fistula. (28028956)
2016
27
Cervical repair of congenital tracheoesophageal fistula: Complications lurking! (27372236)
2016
28
Functional residual capacity and lung clearance index in infants treated for esophageal atresia and tracheoesophageal fistula. (26607967)
2016
29
Effect of cauterizing esophageal mucosa in "double-patch" treatment for acquired benign tracheoesophageal fistula/bronchogastric stump fistula. (28032545)
2016
30
Outcomes of thoracoscopy versus thoracotomy for esophageal atresia with tracheoesophageal fistula repair: A PRISMA-compliant systematic review and meta-analysis. (27472740)
2016
31
Monitoring pre- and postductal saturation - A must for neonates undergoing tracheoesophageal fistula repair. (26725993)
2016
32
Middle Cerebral Artery Stroke in a Neonate With a Congenital Hypercoagulable Condition Following Repair of an H-type Tracheoesophageal Fistula. (27164518)
2016
33
Pedicled posterior pericardial repair of tracheoesophageal fistula after chemoradiotherapy for esophageal cancer. (26948167)
2016
34
Successful Treatment of a Recurrent WideA Tracheoesophageal Fistula With aA Bioabsorbable Patch. (27106472)
2016
35
Esophageal Microperforation due to Calcified Mediastinal Lymph Node Leading to Tracheoesophageal Fistula. (27366334)
2016
36
Anesthetic Management of a Tracheoesophageal Fistula in a Patient With a Large Uncorrected Aortopulmonary Window. (27941485)
2016
37
Congenital H-type tracheoesophageal fistula: a national multicenter study. (26852298)
2016
38
Tracheoesophageal fistula length decreases over time. (26951219)
2016
39
Copy number variations in 375 patients with oesophageal atresia and/or tracheoesophageal fistula. (27436264)
2016
40
Intraoperative ventilatory management of adult tracheoesophageal fistula. (27654741)
2016
41
Esophageal Atresia with Tracheoesophageal Fistula. (27387366)
2016
42
Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair. (27616617)
2016
43
Double Tracheoesophageal Fistula and Azygos Lobe. (27251121)
2016
44
Management of Acquired Tracheoesophageal Fistula Complicating Endoscopic Management for Corrosive Esophageal Stricture. (26802853)
2016
45
Vertebral defect, anal atresia, cardiac defect, tracheoesophageal fistula/esophageal atresia, renal defect, and limb defect association with Mayer-Rokitansky-KA1ster-Hauser syndrome in co-occurrence: two case reports and a review of the literature. (28003020)
2016
46
Combined tracheoinnominate artery fistula and tracheoesophageal fistula: A very rare complication of indwelling tracheostomy tube. (27051118)
2016
47
Endoscopic treatment of recurrent tracheoesophageal fistula with a combination of N-butyl-2-cyanocrylate (Histoacryl(Ar)) and lipiodol via esophagoscopy in a pediatric patient. (26817390)
2016
48
Tracheoesophageal fistula: open versus endoscopic repair. (27653493)
2016
49
ESPGHAN-NASPGHAN Guidelines for the Evaluation and Treatment of Gastrointestinal and Nutritional Complications in Children with Esophageal Atresia- Tracheoesophageal Fistula. (27579697)
2016
50
Determinants of gap length in esophageal atresia with tracheoesophageal fistula and the impact of gap length on outcome. (27365907)
2016

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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Pathways related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6NOG, SHH
29.4GLI3, SHH
3
Show member pathways
9.1FANCI, FANCL

GO Terms for genes affiliated with Tracheoesophageal Fistula

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Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1embryonic skeletal system developmentGO:004870610.4NOG, SHH
2lung morphogenesisGO:006042510.4NOG, SHH
3negative regulation of cell migrationGO:003033610.3NOG, SHH
4embryonic hindlimb morphogenesisGO:003511610.3CHD7, SHH
5anatomical structure developmentGO:004885610.2GLI3, SHH
6anterior/posterior pattern specificationGO:000995210.2GLI3, SHH
7artery developmentGO:006084010.2GLI3, SHH
8branching involved in ureteric bud morphogenesisGO:000165810.2GLI3, SHH
9branching morphogenesis of an epithelial tubeGO:004875410.2GLI3, SHH
10developmental growthGO:004858910.2GLI3, SHH
11embryonic digestive tract morphogenesisGO:004855710.2GLI3, SHH
12embryonic limb morphogenesisGO:003032610.2GLI3, SHH
13embryonic morphogenesisGO:004859810.2GLI3, SHH
14embryonic organ developmentGO:004856810.2GLI3, SHH
15forebrain developmentGO:003090010.2GLI3, SHH
16hindgut morphogenesisGO:000744210.2GLI3, SHH
17inner ear developmentGO:004883910.2GLI3, SHH
18kidney developmentGO:000182210.2GLI3, SHH
19lung developmentGO:003032410.2GLI3, SHH
20metanephros developmentGO:000165610.2GLI3, SHH
21negative regulation of alpha-beta T cell differentiationGO:004663910.2GLI3, SHH
22negative thymic T cell selectionGO:004506010.2GLI3, SHH
23neuron fate commitmentGO:004866310.2GLI3, SHH
24odontogenesis of dentin-containing toothGO:004247510.2GLI3, SHH
25oligodendrocyte differentiationGO:004870910.2GLI3, SHH
26somite developmentGO:006105310.2NOG, SHH
27positive regulation of alpha-beta T cell differentiationGO:004663810.2GLI3, SHH
28positive regulation of neuroblast proliferationGO:000205210.2GLI3, SHH
29positive regulation of protein import into nucleusGO:004230710.2GLI3, SHH
30neural tube developmentGO:002191510.1GLI3, NOG
31smoothened signaling pathwayGO:000722410.0GLI3, SHH
32spinal cord dorsal/ventral patterningGO:002151310.0GLI3, SHH
33spinal cord motor neuron differentiationGO:002152210.0GLI3, SHH
34T cell differentiation in thymusGO:003307710.0GLI3, SHH
35interstrand cross-link repairGO:00362979.9FANCI, FANCL
36anatomical structure formation involved in morphogenesisGO:00486469.8GLI3, NOG, SHH
37axon guidanceGO:00074119.8GLI3, NOG, SHH
38dorsal/ventral pattern formationGO:00099539.8GLI3, NOG, SHH
39embryonic digit morphogenesisGO:00427339.8GLI3, NOG, SHH
40negative regulation of canonical Wnt signaling pathwayGO:00900909.7GLI3, NOG, SHH
41negative regulation of cell differentiationGO:00455969.7GLI3, NOG, SHH
42pattern specification processGO:00073899.7GLI3, NOG, SHH
43camera-type eye developmentGO:00430109.7CHD7, GLI3, SHH
44palate developmentGO:00600219.7CHD7, GLI3, SHH
45in utero embryonic developmentGO:00017019.6CHD7, GLI3, NOG
46regulation of cell proliferationGO:00421279.5FANCL, GLI3, SHH
47wound healingGO:00420609.4GLI3, NOG
48central nervous system developmentGO:00074179.2CHD7, GLI3, NOG, SHH
49limb developmentGO:00601739.2CHD7, GLI3, NOG, SHH
50positive regulation of transcription from RNA polymerase II promoterGO:00459449.1CHD7, GLI3, NOG, SHH

Sources for Tracheoesophageal Fistula

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet