MCID: TRC040
MIFTS: 30

Tracheoesophageal Fistula malady

Summaries for Tracheoesophageal Fistula

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63Wikipedia, 32MalaCards
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Wikipedia:63 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

MalaCards: Tracheoesophageal Fistula, also known as esophageal atresia with or without tracheoesophageal fistula, is related to esophageal atresia and vacterl association. An important gene associated with Tracheoesophageal Fistula is SHH (sonic hedgehog), and among its related pathways are Cardiac Progenitor Differentiation and Hedgehog signaling events mediated by Gli proteins. The compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include trachea, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Tracheoesophageal Fistula

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42NIH Rare Diseases, 44Novoseek
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Aliases & Descriptions:

tracheoesophageal fistula 42 44
esophageal atresia with or without tracheoesophageal fistula 42
tracheoesophageal fistula with or without esophageal atresia 42


Related Diseases for Tracheoesophageal Fistula

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17GeneCards, 18GeneDecks
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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal atresia31.7NOG, SHH
2vacterl association30.6LPP, HOXD13, SHH
3imperforate anus30.4GLI3
4lung cancer30.4PTEN
5choanal atresia30.1CHD7
6cleft palate30.1SHH
7cleft lip30.1SHH
8adenocarcinoma30.1MYCN, PTEN
9leukemia30.1HOXD13, MYCN
10esophagitis11.2
11esophageal atresia/tracheoesophageal fistula10.7
12duodenitis10.5
13laryngitis10.5
14tracheal stenosis10.4
15congenital diaphragmatic hernia10.4
16esophageal cancer10.4
17tracheal agenesis without tracheoesophageal fistula10.4
18cervicitis10.4
19hypertrophic pyloric stenosis10.3
20pyloric stenosis10.3
21respiratory failure10.3
22thyroiditis10.3
23feingold syndrome10.3
24pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.3
25achalasia10.2
26microcephaly10.2
27aspiration pneumonia10.2
28dermatomyositis10.2
29pneumonia10.2
30squamous cell carcinoma10.2
31frias syndrome10.2
32tracheoesophageal fistula symphalangism10.2
33burns10.1
34megaesophagus10.1
35rubella10.1
36rett syndrome10.1
37non-hodgkin lymphoma10.1
38severe acute respiratory syndrome10.1
39urethritis10.1
40renal agenesis10.1
41thyroid lymphoma10.1
42digeorge syndrome10.1
43eosinophilic esophagitis10.1
44esophagus lymphoma10.1
45status asthmaticus10.1
46dextrocardia10.1
47bronchiectasis10.1
48portal hypertension10.1
49barrett's esophagus10.1
50neuronitis10.1

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Clinical Features for Tracheoesophageal Fistula

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Drugs & Therapeutics for Tracheoesophageal Fistula

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tracheoesophageal Fistula

Drug clinical trials:

Search ClinicalTrials for Tracheoesophageal Fistula

Search NIH Clinical Center for Tracheoesophageal Fistula

Search CenterWatch for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Anatomical Context for Tracheoesophageal Fistula

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32MalaCards
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MalaCards organs/tissues related to Tracheoesophageal Fistula:

32
Trachea

Animal Models for Tracheoesophageal Fistula or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.2SHH, MYCN, HOXD13
2MP:00053798.9SOX2, CHD7, HOXD13, NOG
3MP:00053948.9SOX2, SHH, GLI3, NOG, PTEN
4MP:00036318.6ZIC3, SOX2, CHD7, GLI3, NOG
5MP:00053808.4ZIC3, SOX2, SHH, CHD7, GLI3, NOG
6MP:00053778.3ZIC3, SOX2, SHH, CHD7, GLI3, NOG
7MP:00030128.1SOX2, SHH, MYCN, GLI3, HOXD13
8MP:00028738.1ZIC3, SOX2, SHH, MYCN, NOG, PTEN
9MP:00053868.0PTEN, MYCN, CHD7, SHH, SOX2, ZIC3
10MP:00053677.9SHH, MYCN, GLI3, HOXD13, NOG, PTEN
11MP:00107717.8SOX2, SHH, GLI3, HOXD13, NOG, PTEN
12MP:00053977.6ZIC3, FANCA, SHH, CHD7, MYCN, PTEN
13MP:00053887.6ZIC3, SOX2, SHH, CHD7, MYCN, GLI3
14MP:00053767.5SOX2, LPP, SHH, CHD7, MYCN, GLI3
15MP:00053857.4ZIC3, FANCA, SHH, CHD7, MYCN, GLI3
16MP:00053827.2ZIC3, SOX2, FANCA, SHH, CHD7, MYCN
17MP:00053847.2SOX2, FANCA, LPP, SHH, CHD7, MYCN
18MP:00053717.1ZIC3, SHH, CHD7, MYCN, GLI3, HOXD13
19MP:00053816.8ZIC3, SOX2, SHH, CHD7, MYCN, GLI3
20MP:00053916.4SHH, FANCA, SOX2, ZIC3, CHD7, MYCN
21MP:00053906.4SHH, FANCA, SOX2, ZIC3, CHD7, MYCN
22MP:00053786.3ZIC3, SOX2, FANCA, SHH, CHD7, MYCN
23MP:00053895.9PTEN, ZIC3, SOX2, FANCA, LPP, SHH
24MP:00107685.8ZIC3, SOX2, FANCA, LPP, SHH, CHD7

Publications for Tracheoesophageal Fistula

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Genetic Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tracheoesophageal Fistula

Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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37NCBI BioSystems Database, 59Tocris Bioscience, 51QIAGEN
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Pathways related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NOG, SOX2
29.7GLI3, SHH
3
Hide members
9.7GLI3, SHH
49.5SOX2, ZIC3

Compounds for genes affiliated with Tracheoesophageal Fistula

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44Novoseek, 59Tocris Bioscience
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Compounds related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 5910.9NOG, SHH

GO Terms for genes affiliated with Tracheoesophageal Fistula

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16Gene Ontology
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Cellular components related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056345.8PTEN, SOX2, FANCA, LPP, SHH, CHD7

Biological processes related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:06105310.3NOG, SHH
2embryonic skeletal system developmentGO:04870610.2NOG, SHH
3neuron fate commitmentGO:04866310.2SHH, SOX2
4limb developmentGO:06017310.1NOG, CHD7
5negative regulation of alpha-beta T cell differentiationGO:04663910.1SHH, GLI3
6hindgut morphogenesisGO:00744210.1GLI3, SHH
7artery developmentGO:06084010.1SHH, GLI3
8pituitary gland developmentGO:02198310.1NOG, SOX2
9positive regulation of alpha-beta T cell differentiationGO:04663810.1GLI3, SHH
10negative thymic T cell selectionGO:04506010.1GLI3, SHH
11positive regulation of protein import into nucleusGO:04230710.1GLI3, SHH
12embryonic hindlimb morphogenesisGO:03511610.1SHH, CHD7
13tongue developmentGO:04358610.1SOX2, GLI3
14dorsal/ventral pattern formationGO:00995310.0SHH, NOG
15somatic stem cell maintenanceGO:03501910.0NOG, SOX2
16negative regulation of osteoblast differentiationGO:04566810.0NOG, SOX2
17T cell differentiation in thymusGO:03307710.0SHH, GLI3
18inner ear developmentGO:04883910.0SHH, SOX2
19metanephros developmentGO:00165610.0SHH, GLI3
20positive regulation of neuroblast proliferationGO:0020529.8SOX2, SHH, GLI3
21negative regulation of cell migrationGO:0303369.8SHH, NOG, PTEN
22palate developmentGO:0600219.8GLI3, CHD7, SHH
23smoothened signaling pathwayGO:0072249.7GLI3, SHH
24negative regulation of neuron differentiationGO:0456659.7SOX2, GLI3
25negative regulation of epithelial cell proliferationGO:0506809.7PTEN, SOX2
26central nervous system developmentGO:0074179.7SHH, CHD7, PTEN
27branching involved in ureteric bud morphogenesisGO:0016589.6GLI3, SHH
28in utero embryonic developmentGO:0017019.6NOG, GLI3, CHD7
29heart developmentGO:0075079.5PTEN, GLI3, SHH
30negative regulation of canonical Wnt receptor signaling pathwayGO:0900909.5SOX2, SHH, GLI3, NOG
31lung developmentGO:0303249.5GLI3, SHH, ZIC3
32male genitalia developmentGO:0305399.4HOXD13, SHH, SOX2
33negative regulation of transcription from RNA polymerase II promoterGO:0001229.4SOX2, SHH, GLI3, NOG
34regulation of cell proliferationGO:0421279.3FANCA, SHH, HOXD13
35skeletal system developmentGO:0015019.3CHD7, HOXD13, NOG
36heart loopingGO:0019479.3SHH, ZIC3
37positive regulation of transcription, DNA-dependentGO:0458939.1ZIC3, SOX2, SHH, GLI3
38embryonic digit morphogenesisGO:0427339.0NOG, HOXD13, GLI3, SHH
39anterior/posterior pattern specificationGO:0099528.7HOXD13, GLI3, SHH, ZIC3
40positive regulation of transcription from RNA polymerase II promoterGO:0459448.1ZIC3, SOX2, SHH, GLI3, HOXD13, NOG

Molecular functions related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036828.4SOX2, CHD7, GLI3, HOXD13
2sequence-specific DNA bindingGO:0435658.2HOXD13, GLI3, SOX2, ZIC3
3sequence-specific DNA binding transcription factor activityGO:0037007.6ZIC3, SOX2, MYCN, GLI3, HOXD13
4protein bindingGO:0055156.3PTEN, ZIC3, SOX2, FANCA, LPP, SHH

Products for genes affiliated with Tracheoesophageal Fistula

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Sources for Tracheoesophageal Fistula

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet