MCID: TRC040
MIFTS: 44

Tracheoesophageal Fistula malady

Summaries for Tracheoesophageal Fistula

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

MalaCards: Tracheoesophageal Fistula, also known as esophageal atresia with or without tracheoesophageal fistula, is related to esophageal atresia and vacterl association. An important gene associated with Tracheoesophageal Fistula is SHH (sonic hedgehog), and among its related pathways are Cardiac Progenitor Differentiation and Hedgehog signaling events mediated by Gli proteins. The compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and colon, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Aliases & Classifications for Tracheoesophageal Fistula

Sources:
43NIH Rare Diseases, 45Novoseek
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Aliases & Descriptions:

tracheoesophageal fistula 43 45
esophageal atresia with or without tracheoesophageal fistula 43
tracheoesophageal fistula with or without esophageal atresia 43


Related Diseases for Tracheoesophageal Fistula

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal atresia31.8NOG, SHH
2vacterl association30.6LPP, SHH, HOXD13
3imperforate anus30.5GLI3
4cleft palate30.1SHH
5adenocarcinoma30.1MYCN, PTEN
6esophageal atresia/tracheoesophageal fistula11.2
7anal fistula10.6
8duodenal atresia10.5
9tracheal stenosis10.4
10congenital diaphragmatic hernia10.4
11tracheal agenesis10.4
12tracheal agenesis without tracheoesophageal fistula10.4
13hypertrophic pyloric stenosis10.3
14pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.3
15achalasia10.2
16microcephaly10.2
17adenoma10.2
18aspiration pneumonia10.2
19squamous cell carcinoma10.2
20micro syndrome10.2
21laryngeal cleft10.2
22feingold syndrome10.2
23tricuspid atresia10.2
24lung agenesis10.2
25congenital tracheal stenosis10.2
26frias syndrome10.2
27tracheoesophageal fistula symphalangism10.2
28dysphagia10.2
29pulmonary function10.2
30esophageal squamous cell carcinoma10.2
31esophageal duplication cyst10.2
32burns10.1
33megaesophagus10.1
34rubella10.1
35rett syndrome10.1
36severe acute respiratory syndrome10.1
37renal agenesis10.1
38thyroid lymphoma10.1
39digeorge syndrome10.1
40eosinophilic esophagitis10.1
41esophagus lymphoma10.1
42status asthmaticus10.1
43dextrocardia10.1
44bronchiectasis10.1
45portal hypertension10.1
46hypoplastic left heart syndrome10.1
47actinomycosis10.1
48situs inversus10.1
49gastroesophageal reflux disease10.1
50adult dermatomyositis10.1

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Clinical Features for Tracheoesophageal Fistula

Drugs & Therapeutics for Tracheoesophageal Fistula

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Tracheoesophageal Fistula

Drug clinical trials:

Search ClinicalTrials for Tracheoesophageal Fistula

Search NIH Clinical Center for Tracheoesophageal Fistula

Search CenterWatch for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

Anatomical Context for Tracheoesophageal Fistula

Sources:
33MalaCards
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MalaCards organs/tissues related to Tracheoesophageal Fistula:

33
Bone marrow, Heart, Colon, Kidney, Lung, Pancreas, Thyroid, Skin, T cells, B lymphoblasts, B cells, Fetal lung, Trachea, Fetal thyroid

Animal Models for Tracheoesophageal Fistula or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.2SHH, MYCN, HOXD13
2MP:00053798.9SOX2, HOXD13, CHD7, NOG
3MP:00053948.9SHH, GLI3, PTEN, NOG, SOX2
4MP:00036318.6SOX2, CHD7, NOG, GLI3, ZIC3
5MP:00053808.4GLI3, CHD7, SHH, SOX2, ZIC3, NOG
6MP:00053778.3ZIC3, SOX2, SHH, CHD7, GLI3, NOG
7MP:00030128.1HOXD13, GLI3, SHH, SOX2, MYCN
8MP:00028738.1SOX2, SHH, ZIC3, MYCN, PTEN, NOG
9MP:00053868.0SOX2, PTEN, MYCN, SHH, ZIC3, CHD7
10MP:00053677.9HOXD13, SHH, MYCN, GLI3, PTEN, NOG
11MP:00107717.8PTEN, NOG, SOX2, GLI3, SHH, HOXD13
12MP:00053977.6ZIC3, FANCA, SHH, MYCN, PTEN, CHD7
13MP:00053887.6CHD7, MYCN, PTEN, GLI3, ZIC3, SHH
14MP:00053767.5SHH, PTEN, NOG, GLI3, MYCN, LPP
15MP:00053857.4MYCN, FANCA, PTEN, NOG, GLI3, SHH
16MP:00053827.2MYCN, GLI3, SOX2, SHH, CHD7, FANCA
17MP:00053847.2SHH, LPP, GLI3, NOG, PTEN, FANCA
18MP:00053717.1NOG, GLI3, PTEN, CHD7, SHH, ZIC3
19MP:00053816.8PTEN, ZIC3, HOXD13, SOX2, SHH, CHD7
20MP:00053916.4ZIC3, PTEN, SOX2, FANCA, SHH, CHD7
21MP:00053906.4ZIC3, SOX2, FANCA, CHD7, MYCN, GLI3
22MP:00053786.3GLI3, PTEN, NOG, ZIC3, HOXD13, SOX2
23MP:00053895.9HOXD13, SOX2, FANCA, LPP, SHH, CHD7
24MP:00107685.8FANCA, ZIC3, LPP, SHH, CHD7, MYCN

Publications for Tracheoesophageal Fistula

Sources:
51PubMed
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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Emergency Out-of-Hospital Presentation of Neonatal Esophageal Atresia with Tracheoesophageal Fistula. (24435793)
2014
2
Preserving the azygos vein when repairing esophageal atresia and tracheoesophageal fistula accompanied by interrupted inferior vena cava. (24122074)
2013
3
Video: argon plasma coagulator in a 2-month-old child with tracheoesophageal fistula. (22476825)
2012
4
Congenital tracheoesophageal fistula. (22272674)
2012
5
Delayed identification of proximal tracheoesophageal fistula. (22832509)
2012
6
Tracheoesophageal fistula with esophageal atresia with absent external ear: a unusual association. (23904729)
2012
7
Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer. (21769294)
2011
8
Acquired nonmalignant tracheoesophageal fistula. (22259906)
2011
9
Novel use of glycopyrrolate (Robinul) in the treatment of anastomotic leak after repair of esophageal atresia and tracheoesophageal fistula. (21376184)
2011
10
Anesthetic management of congenital tracheoesophageal fistula. (20723095)
2011
11
Diagnosis of esophageal atresia with tracheoesophageal fistula: is there a need for gastrointestinal contrast? (20056230)
2010
12
Etiology of esophageal atresia and tracheoesophageal fistula: "mind the gap". (20425471)
2010
13
Acute gastric volvulus in operated cases of tracheoesophageal fistula. (21180502)
2010
14
Role of reflux in tracheoesophageal fistula problems after laryngectomy. (21140630)
2010
15
Endoscopic treatment of recurrent tracheoesophageal fistula with histoacryl glue. (21111878)
2010
16
Coexisting congenital diaphragmatic hernia, esophageal atresia, and tracheoesophageal fistula: a case report and review of the literature. (18828268)
2008
17
A congenital proximal tracheoesophageal fistula 14 years after surgical repair of esophageal atresia with distal tracheoesophageal fistula. (18773681)
2008
18
Endoscopic management of recurrent tracheoesophageal fistula with trichloroacetic acid chemocauterization: a preliminary report. (18970956)
2008
19
Feingold syndome: a rare but important cause of syndromic tracheoesophageal fistula. (17848225)
2007
20
Endoscopic management of recurrent congenital tracheoesophageal fistula: a review of techniques and results. (17408757)
2007
21
Triple fistula: management of a double tracheoesophageal fistula with a third H-type proximal fistula. (17560187)
2007
22
Prognosis of congenital tracheoesophageal fistula with esophageal atresia on the basis of gap length. (17579871)
2007
23
Medical image. Advanced oesophageal cancer complicated with tracheoesophageal fistula and aspiration pneumonia. (17514214)
2007
24
Scoliosis caused by rib fusion following thoracotomy for tracheoesophageal fistula: case report. (17907438)
2007
25
Complications of the tracheal diverticulum after division of congenital tracheoesophageal fistula. (16567205)
2006
26
Tracheoesophageal fistula without esophageal atresia: are pull-back tube esophagograms needed for diagnosis? (16967270)
2006
27
The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: an animal study. (16871620)
2006
28
Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula: lessons learned. (16646712)
2006
29
Tracheoesophageal fistula in a child after blunt chest trauma. (17011255)
2006
30
Single-stage repair of a large acquired tracheoesophageal fistula with interposition of 2 muscle pedicle flaps and laparoscopic gastrojejunostomy. (16733188)
2006
31
Transillumination of H-type tracheoesophageal fistula using flexible miniature bronchoscopy: an innovative technique for operative localization. (15991163)
2005
32
Closure of a cervical H-type tracheoesophageal fistula. (15002079)
2004
33
A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. (12632368)
2003
34
Pathologic quiz case: a woman with dysphagia and unusual histologic findings in the esophagus. Residual tracheobronchial remnants, consistent with the history of TEF. Tracheoesophageal fistula. (14567747)
2003
35
Costal cartilage grafting for repair of a recurrent tracheoesophageal fistula in a 1.6-kg baby with esophageal atresia. (11956786)
2002
36
Expression of the lung-specific thyroid transcription factor (TTF-1) within the tracheoesophageal fistula of embryo rats exposed to Adriamycin. (10813360)
2000
37
Revisiting the role of routine retropleural drainage after repair of esophageal atresia with distal tracheoesophageal fistula. (10442595)
1999
38
A new variant of esophageal atresia with tracheoesophageal fistula and duodenal atresia: a diagnostic dilemma (9069229)
1997
39
An improved method of flexible endoscopic creation of tracheoesophageal fistula for voice restoration. (9381345)
1997
40
Aortic arch anomalies associated with long gap esophageal atresia and tracheoesophageal fistula. (9396531)
1997
41
Management of acquired tracheoesophageal fistula. (8934011)
1996
42
Congenital tracheoesophageal fistula: preventing recurrence. (8811561)
1996
43
Delayed presentation of a tracheoesophageal fistula after blunt chest trauma. (8957406)
1996
44
Narrowing the embryologic window of the adriamycin-induced fetal rat model of esophageal atresia and tracheoesophageal fistula. (24057779)
1996
45
Simultaneous Bochdalek hernia and type C tracheoesophageal fistula. (7658682)
1995
46
Unilateral pulmonary agenesis with tracheoesophageal fistula: a case report. (8786513)
1995
47
Esophageal Atresia/Tracheoesophageal Fistula Overview (20301753)
1993
48
Unusual foreign body (stone) in the esophagus of a neonate mimicking tracheoesophageal fistula. (8132295)
1993
49
Survival following gastrointestinal perforation from esophageal atresia and tracheoesophageal fistula. (8301521)
1993
50
Tracheoesophageal fistula complicating herpes esophagitis in AIDS. (8470643)
1993

Genetic Variations for Tracheoesophageal Fistula

Expression for genes affiliated with Tracheoesophageal Fistula

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tracheoesophageal Fistula

Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

Sources:
38NCBI BioSystems Database, 60Tocris Bioscience, 52QIAGEN
See all sources

Pathways related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NOG, SOX2
29.7GLI3, SHH
3
Hide members
9.7GLI3, SHH
49.5SOX2, ZIC3

Compounds for genes affiliated with Tracheoesophageal Fistula

Sources:
45Novoseek, 60Tocris Bioscience
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Compounds related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine45 6010.9NOG, SHH

GO Terms for genes affiliated with Tracheoesophageal Fistula

Sources:
16Gene Ontology
See all sources

Cellular components related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056345.8PTEN, SOX2, FANCA, LPP, SHH, CHD7

Biological processes related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:06105310.3NOG, SHH
2embryonic skeletal system developmentGO:04870610.2NOG, SHH
3neuron fate commitmentGO:04866310.2SHH, SOX2
4limb developmentGO:06017310.1NOG, CHD7
5negative regulation of alpha-beta T cell differentiationGO:04663910.1SHH, GLI3
6hindgut morphogenesisGO:00744210.1GLI3, SHH
7artery developmentGO:06084010.1SHH, GLI3
8pituitary gland developmentGO:02198310.1NOG, SOX2
9positive regulation of alpha-beta T cell differentiationGO:04663810.1GLI3, SHH
10negative thymic T cell selectionGO:04506010.1GLI3, SHH
11positive regulation of protein import into nucleusGO:04230710.1GLI3, SHH
12embryonic hindlimb morphogenesisGO:03511610.1SHH, CHD7
13tongue developmentGO:04358610.1SOX2, GLI3
14dorsal/ventral pattern formationGO:00995310.0SHH, NOG
15somatic stem cell maintenanceGO:03501910.0NOG, SOX2
16negative regulation of osteoblast differentiationGO:04566810.0NOG, SOX2
17T cell differentiation in thymusGO:03307710.0SHH, GLI3
18inner ear developmentGO:04883910.0SHH, SOX2
19metanephros developmentGO:00165610.0SHH, GLI3
20positive regulation of neuroblast proliferationGO:0020529.8SOX2, SHH, GLI3
21negative regulation of cell migrationGO:0303369.8SHH, NOG, PTEN
22palate developmentGO:0600219.8GLI3, CHD7, SHH
23smoothened signaling pathwayGO:0072249.7GLI3, SHH
24negative regulation of neuron differentiationGO:0456659.7SOX2, GLI3
25negative regulation of epithelial cell proliferationGO:0506809.7PTEN, SOX2
26central nervous system developmentGO:0074179.7SHH, CHD7, PTEN
27branching involved in ureteric bud morphogenesisGO:0016589.6GLI3, SHH
28in utero embryonic developmentGO:0017019.6NOG, GLI3, CHD7
29heart developmentGO:0075079.5PTEN, GLI3, SHH
30negative regulation of canonical Wnt receptor signaling pathwayGO:0900909.5SOX2, SHH, GLI3, NOG
31lung developmentGO:0303249.5GLI3, SHH, ZIC3
32male genitalia developmentGO:0305399.4HOXD13, SHH, SOX2
33negative regulation of transcription from RNA polymerase II promoterGO:0001229.4SOX2, SHH, GLI3, NOG
34regulation of cell proliferationGO:0421279.3FANCA, SHH, HOXD13
35skeletal system developmentGO:0015019.3CHD7, HOXD13, NOG
36heart loopingGO:0019479.3SHH, ZIC3
37positive regulation of transcription, DNA-dependentGO:0458939.1ZIC3, SOX2, SHH, GLI3
38embryonic digit morphogenesisGO:0427339.0NOG, HOXD13, GLI3, SHH
39anterior/posterior pattern specificationGO:0099528.7HOXD13, GLI3, SHH, ZIC3
40positive regulation of transcription from RNA polymerase II promoterGO:0459448.1ZIC3, SOX2, SHH, GLI3, HOXD13, NOG

Molecular functions related to Tracheoesophageal Fistula according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin bindingGO:0036828.4HOXD13, CHD7, GLI3, SOX2
2sequence-specific DNA bindingGO:0435658.2HOXD13, GLI3, SOX2, ZIC3
3sequence-specific DNA binding transcription factor activityGO:0037007.6ZIC3, HOXD13, GLI3, MYCN, SOX2
4protein bindingGO:0055156.3GLI3, PTEN, MYCN, CHD7, SHH, LPP

Products for genes affiliated with Tracheoesophageal Fistula

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Sources for Tracheoesophageal Fistula

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet