MCID: TRC040
MIFTS: 41

Tracheoesophageal Fistula malady

Category: Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

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Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 45 47 24
Tracheoesophageal Fistula with or Without Esophageal Atresia 45
 
Te Fistula 45
Tef 45

Classifications:



Summaries for Tracheoesophageal Fistula

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NIH Rare Diseases:45 Tracheoesophageal fistula (tef) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). the esophagus and trachea run next to each other through the chest cavity. the esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. tef can lead to severe and fatal lung complications. saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. most affected people are diagnosed immediately after birth or during infancy. symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. tef may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). in many cases the cause is unknown but it has been associated with some chromosome disorders. in some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. treatment includes immediate surgical repair with survival rates of almost 100%. last updated: 7/8/2015

MalaCards based summary: Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to tracheoesophageal fistula symphalangism and esophageal atresia/tracheoesophageal fistula, and has symptoms including tracheoesophageal fistulaand esophageal atresia. An important gene associated with Tracheoesophageal Fistula is SHH (Sonic Hedgehog). Affiliated tissues include trachea, lung and breast, and related mouse phenotypes are taste/olfaction and integument.

Wikipedia:68 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

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Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms for Tracheoesophageal Fistula

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HPO human phenotypes related to Tracheoesophageal Fistula:

id Description Frequency HPO Source Accession
1 tracheoesophageal fistula HP:0002575
2 esophageal atresia HP:0002032

Drugs & Therapeutics for Tracheoesophageal Fistula

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Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1threonineNutraceutical17

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endoscopic Closure of Tracheoesophageal Fistulas With Occluder DeviceTerminatedNCT01153061Phase 4
2Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesRecruitingNCT01467245
3Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula RepairRecruitingNCT01287312
4A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 MonthsEnrolling by invitationNCT02364843
5Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

33
Trachea, Lung, Breast, Endothelial, Liver, Kidney, Heart

Animal Models for Tracheoesophageal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2NOG, PTEN, SHH
2MP:00107718.7HOXD13, NOG, PTEN, SHH
3MP:00053828.6CHD7, NOG, SHH, ZIC3
4MP:00053678.5HOXD13, NOG, PTEN, SHH
5MP:00053798.2CHD7, HOXD13, NOG, PTEN, SHH
6MP:00053778.2CHD7, NOG, SHH, ZIC3
7MP:00053888.0CHD7, NOG, PTEN, SHH, ZIC3
8MP:00053697.9CHD7, HOXD13, NOG, PTEN, SHH
9MP:00036317.9CHD7, NOG, PTEN, SHH, ZIC3
10MP:00053847.9CHD7, NOG, PTEN, SHH, ZIC3
11MP:00053807.6CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
12MP:00053857.5CHD7, NOG, PTEN, SHH, ZIC3
13MP:00053717.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
14MP:00053897.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
15MP:00053917.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
16MP:00053817.4CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
17MP:00107687.2CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
18MP:00053787.1CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
19MP:00053907.1CHD7, HOXD13, NOG, PTEN, SHH, ZIC3

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome. (26940669)
2016
2
Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder. (24726793)
2014
3
Is Nox4 a key regulator of the activated state of fibroblasts in systemic sclerosis? (25040787)
2014
4
Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn's disease: A meta-analysis. (24307809)
2013
5
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. (23260135)
2012
6
Intravitreal bevacizumab for choroidal neovascularization secondary to laser photocoagulation for central serous chorioretinopathy. (21928270)
2012
7
Ultrasound prognostic factors after laser surgery for twin-twin transfusion syndrome to predict survival at 6 months. (21905054)
2011
8
Damage and recovery of the bone marrow microenvironment induced by cancer chemotherapy - potential regulatory role of chemokine CXCL12/receptor CXCR4 signalling. (20540706)
2010
9
CD 28 gene polymorphism and plasma concentration of soluble CD 28 in Iranian patients with visceral leishmaniasis. (20962715)
2010
10
Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases]. (19947439)
2009
11
Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia. (17096407)
2008
12
Progressive multifocal leukoencephalopathy in purine nucleoside phosphorylase deficiency. (16949240)
2007
13
14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma. (17391729)
2007
14
Disease progression, response to ACEI/ATRA therapy and influence of ACE gene in IgA nephritis. (17601378)
2007
15
Tc-99m ciprofloxacin (infecton) in abdominal tuberculosis. (16495737)
2006
16
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol. (16709245)
2006
17
Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells. (16571667)
2006
18
Potential nectin-1 binding site on herpes simplex virus glycoprotein d. (15613355)
2005
19
Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. (15980098)
2005
20
Body composition characteristics and fat distribution patterns in young infertile women. (15037399)
2004
21
Mechanisms of antigen receptor evolution. (15522620)
2004
22
Pathologic quiz case: a man with exertion-induced cramps and myoglobinuria. McArdle disease (glycogenosis type V or myophosphorylase deficiency). (12951997)
2003
23
Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. (12615620)
2003
24
SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase- type plasminogen activator receptor superfamily with a role in sperm- egg interaction. (12788941)
2003
25
Surgical stress during operation for gastrointestinal cancer increases plasma thioredoxin levels and decreases mitochondrial membrane potential in peripheral blood lymphocytes. (12189047)
2002
26
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress. (11226337)
2001
27
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. (11606272)
2001
28
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
29
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. (11035805)
2000
30
Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. (10357799)
1999
31
Type 2B Hiroshima: a variant of von Willebrand disease characterized by chronic thrombocytopenia and the presence of all von Willebrand factor multimers in plasma. (10497852)
1999
32
Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. (9684753)
1998
33
Protease resistance of syntaxin.SNAP-25.VAMP complexes. Implications for assembly and structure. (9556632)
1998
34
Integrating cytosolic calcium signals into mitochondrial metabolic responses. (9724635)
1998
35
Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. (10072590)
1998
36
Muscle and tendon size relationships in a paralyzed chick embryo model of clubfoot. (9600555)
1998
37
Erysipelas: clinical and bacteriologic spectrum and serological aspects. (8922808)
1996
38
Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by beta-estradiol, progesterone, and dexamethasone. (8548848)
1996
39
Clear cell hidradenoma simulating breast carcinoma: a diagnostic pitfall in fine-needle aspiration of breast. (8807256)
1996
40
Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg-353-->Pro leading to loss of a kallikrein cleavage site. (8049433)
1994
41
Rapid diagnosis of scrub typhus by a passive hemagglutination assay using recombinant 56-kilodalton polypeptides. (8370730)
1993
42
Neuropsychiatric aspects of Sydenham's chorea: a case report. (8358529)
1993
43
Antineoplastic activities and cytotoxicity of 1-acyl and 1,2-diacyl-1,2,4-triazolidine-3,5-diones in murine and human tissue culture cells. (1444191)
1992
44
Macrophage colony-stimulating factor: biological effects and potential applications for cancer therapy. (1829550)
1991
45
Orchitis--an unusual complication of typhoid fever. (2632524)
1989
46
Pneumococcal meningitis with purpura. (4055694)
1985
47
Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry. (6201481)
1984
48
Treatment of congenital factor VII deficiency with a new concentrate. (705696)
1978
49
Ultrastructure of epithelial lining of keratocysts in nevoid basal cell carcinoma syndrome. (818041)
1976
50

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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GO Terms for genes affiliated with Tracheoesophageal Fistula

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Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:006105310.1NOG, SHH
2forebrain developmentGO:003090010.1NOG, SHH
3embryonic skeletal system developmentGO:004870610.1NOG, SHH
4negative regulation of cell differentiationGO:004559610.1NOG, SHH
5dorsal/ventral pattern formationGO:000995310.1NOG, SHH
6camera-type eye developmentGO:004301010.0CHD7, SHH
7embryonic hindlimb morphogenesisGO:003511610.0CHD7, SHH
8determination of left/right symmetryGO:00073689.8SHH, ZIC3
9negative regulation of canonical Wnt signaling pathwayGO:00900909.8NOG, SHH
10negative regulation of gene expressionGO:00106299.8NOG, SHH
11skeletal system developmentGO:00015019.8CHD7, NOG
12limb developmentGO:00601739.6CHD7, NOG, SHH
13embryonic digit morphogenesisGO:00427339.6HOXD13, NOG, SHH
14canonical Wnt signaling pathwayGO:00600709.6PTEN, SHH
15palate developmentGO:00600219.4CHD7, SHH
16anterior/posterior pattern specificationGO:00099529.4HOXD13, SHH, ZIC3
17pattern specification processGO:00073899.3NOG, SHH, ZIC3
18anatomical structure formation involved in morphogenesisGO:00486469.3NOG, SHH
19locomotory behaviorGO:00076269.1CHD7, PTEN
20negative regulation of cell migrationGO:00303368.9NOG, PTEN, SHH
21central nervous system developmentGO:00074178.7CHD7, NOG, PTEN, SHH
22positive regulation of transcription from RNA polymerase II promoterGO:00459448.5HOXD13, NOG, SHH, ZIC3

Sources for Tracheoesophageal Fistula

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet