MCID: TRC040
MIFTS: 40

Tracheoesophageal Fistula malady

Rare diseases category

Aliases & Classifications for Tracheoesophageal Fistula

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Sources:
45NIH Rare Diseases, 47Novoseek
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Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 45 47
Tracheoesophageal Fistula with or Without Esophageal Atresia 45
 
Te Fistula 45
Tef 45


Classifications:



Summaries for Tracheoesophageal Fistula

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NIH Rare Diseases:45 Tracheoesophageal fistula (tef) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). the esophagus and trachea run next to each other through the chest cavity. the esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. tef can lead to severe and fatal lung complications. saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. most affected people are diagnosed immediately after birth or during infancy. symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. tef may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). in many cases the cause is unknown but it has been associated with some chromosome disorders. in some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. treatment includes immediate surgical repair with survival rates of almost 100%. last updated: 7/8/2015

MalaCards based summary: Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to heart septal defect and hypoplastic left heart syndrome, and has symptoms including esophageal atresiaand tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is SHH (Sonic Hedgehog). Affiliated tissues include trachea, lung and bone, and related mouse phenotypes are taste/olfaction and hearing/vestibular/ear.

Wikipedia:68 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1heart septal defect30.2PTEN, ZIC3
2hypoplastic left heart syndrome30.1PTEN, ZIC3
3tracheoesophageal fistula symphalangism29.2CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
4esophagitis11.3
5esophageal atresia11.3
6esophageal atresia/tracheoesophageal fistula10.8
7duodenitis10.6
8laryngitis10.6
9tracheal agenesis without tracheoesophageal fistula10.6
10tracheomalacia10.5
11duodenal atresia10.5
12feingold syndrome10.5
13tracheal stenosis10.5
14esophageal cancer10.5
15congenital diaphragmatic hernia10.5
16tracheal agenesis10.5
17lung cancer10.4
18vacterl association10.4
19hypertrophic pyloric stenosis10.4
20cervicitis10.4
21pyloric stenosis10.4
22pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.4
23gastroesophageal reflux10.4
24vacterl association, x-linked10.4
25imperforate anus10.4
26mediastinitis10.4
27respiratory failure10.4
28thyroiditis10.4
29laryngeal cleft10.4
30right aortic arch10.4
31epidermolysis bullosa dystrophica, ar10.3
32mitchell-riley syndrome10.3
33charge syndrome10.3
34vater association with macrocephaly and ventriculomegaly10.3
35fanconi anemia, complementation group b10.3
36achalasia10.3
37microcephaly10.3
38situs inversus10.3
39aspiration pneumonia10.3
40congenital heart disease10.3
41dermatomyositis10.3
42pneumonia10.3
43congenital tracheal stenosis10.3
44tricuspid atresia10.3
45dysphagia10.3
46dwarfism10.2
47caudal regression syndrome10.1
48fanconi anemia, complementation group l10.1
49ulna and fibula, absence of, with severe limb deficiency10.1
50hodgkin lymphoma10.1

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms for Tracheoesophageal Fistula

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HPO human phenotypes related to Tracheoesophageal Fistula:

id Description Frequency HPO Source Accession
1 esophageal atresia HP:0002032
2 tracheoesophageal fistula HP:0002575

Drugs & Therapeutics for Tracheoesophageal Fistula

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Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1threonineNutraceutical16

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endoscopic Closure of Tracheoesophageal Fistulas With Occluder DeviceTerminatedNCT01153061Phase 4
2Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesRecruitingNCT01467245
3Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula RepairRecruitingNCT01287312
4A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 MonthsEnrolling by invitationNCT02364843
5Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

33
Trachea, Lung, Bone, Colon, Thyroid, Heart, T cells

Animal Models for Tracheoesophageal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.8NOG, PTEN, SHH
2MP:00053778.9CHD7, NOG, SHH, ZIC3
3MP:00028738.9NOG, PTEN, SHH, ZIC3
4MP:00053698.6HOXD13, NOG, PTEN, SHH
5MP:00053678.6HOXD13, NOG, PTEN, SHH
6MP:00053828.4CHD7, NOG, PTEN, SHH, ZIC3
7MP:00107718.3HOXD13, NOG, PTEN, SHH
8MP:00053858.2CHD7, NOG, PTEN, SHH, ZIC3
9MP:00053888.1CHD7, NOG, PTEN, SHH, ZIC3
10MP:00053797.7CHD7, HOXD13, NOG, PTEN, SHH
11MP:00053907.6CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
12MP:00053717.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
13MP:00053817.5CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
14MP:00053807.4CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
15MP:00107687.3CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
16MP:00053917.3CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
17MP:00053787.3CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
18MP:00036317.0CHD7, HOXD13, NOG, PTEN, SHH, ZIC3
19MP:00053896.8CHD7, HOXD13, NOG, PTEN, SHH, ZIC3

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
Esophageal Dysmotility Is Present Before Surgery in Isolated Tracheoesophageal Fistula. (25493344)
2015
2
Endoscopic closure of tracheoesophageal fistula with submucosal dissection and a biosynthetic mesh. (26115391)
2015
3
A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. (25783403)
2015
4
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
5
Management of a congenital tracheoesophageal fistula in a young Spanish water dog. (24423070)
2014
6
VACTERL (Vertebral Defects, Anal Atresia, Tracheoesophageal Fistula withA Esophageal Atresia, Cardiac Defects, Renal and Limb Anomalies) Association: Disease Spectrum in 25 Patients Ascertained for Their UpperA Limb Involvement. (24210691)
2013
7
A case series study of therapeutic implications of type IIIb4: a rare variant of esophageal atresia and distal tracheoesophageal fistula. (23895955)
2013
8
Video: argon plasma coagulator in a 2-month-old child with tracheoesophageal fistula. (22476825)
2012
9
Thoracoscopic treatment of congenital esophageal stenosis in combination with H-type tracheoesophageal fistula. (22901927)
2012
10
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
11
Selective bilateral bronchial intubation for large, acquired tracheoesophageal fistula. (22474805)
2012
12
Congenital tracheoesophageal fistula. (22272674)
2012
13
Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association. (22639458)
2012
14
Analysis of saliva pepsin level in patients with tracheoesophageal fistula and voice prosthesis complications. (23397763)
2012
15
Usefulness of dextranomer/hyaluronic acid copolymer in bronchoscopic treatment of recurrent tracheoesophageal fistula in children. (21782257)
2011
16
Choanal atresia associated with tracheoesophageal fistula: the spectrum of carbimazole embryopathy. (21807695)
2011
17
Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer. (21769294)
2011
18
Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistula. (20112230)
2010
19
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
20
Diagnosis of esophageal atresia with tracheoesophageal fistula: is there a need for gastrointestinal contrast? (20056230)
2010
21
Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. (20054858)
2010
22
Esophageal atresia/tracheoesophageal fistula in very low-birth-weight neonates: improved outcomes with staged repair. (20006009)
2009
23
Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema. (19908119)
2009
24
Sternohyoid muscle flap interposition in the treatment of an acquired tracheoesophageal fistula. (19260113)
2009
25
Longitudinal follow-up of bronchial inflammation, respiratory symptoms, and pulmonary function in adolescents after repair of esophageal atresia with tracheoesophageal fistula. (18534205)
2008
26
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
27
Severe stridor following the repair of H-type tracheoesophageal fistula in an 11 month infant. (19235526)
2008
28
Feingold syndome: a rare but important cause of syndromic tracheoesophageal fistula. (17848225)
2007
29
An unknown second tracheoesophageal fistula: a rare cause of postoperative respiratory failure. (16618307)
2006
30
Anesthetic management of tracheoesophageal fistula repair in a newborn with hypoplastic left heart syndrome. (16677272)
2006
31
Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. (16818050)
2006
32
High-grade congenital esophageal stenosis owing to a membranous diaphragm with tracheoesophageal fistula. (16226967)
2005
33
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
34
An endotracheal/tracheostomy tube technique for the emergency management of a midtracheal tracheoesophageal fistula. (12819001)
2003
35
Tracheoesophageal fistula caused by a self-expanding esophageal stent. (10215238)
1999
36
Simplifying the Waterston's stratification of infants with tracheoesophageal fistula. (10515532)
1999
37
Successful long-term endoscopic closure of a recurrent tracheoesophageal fistula with fibrin glue in a child. (10402124)
1999
38
Esophageal patching for an unsuturable tracheoesophageal fistula. (9845151)
1998
39
Split pectoralis major flap for massive tracheoesophageal fistula. (9419118)
1997
40
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
41
Esophageal duplication cyst with esophageal web and tracheoesophageal fistula. (8811570)
1996
42
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
43
Use of an intratracheal silicone prosthesis (Dumon type) for the treatment of tracheoesophageal fistula due to advanced lung cancer. (8931224)
1996
44
Bronchoscopy and occlusion of tracheoesophageal fistula. (8638821)
1996
45
Radiology rounds. Tracheoesophageal fistula. (7787487)
1995
46
Simple technique for proximal pouch mobilization and circular myotomy in cases of esophageal atresia with tracheoesophageal fistula. (7807338)
1994
47
Recurrent tracheoesophageal fistula treated with fibrin glue. (7877030)
1994
48
Tracheoesophageal fistula caused by mycobacterial tuberculosis adenopathy. (8512414)
1993
49
Esophageal atresia and tracheoesophageal fistula in children. (8374655)
1993
50
Esophageal Atresia/Tracheoesophageal Fistula Overview (20301753)
1993

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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GO Terms for genes affiliated with Tracheoesophageal Fistula

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Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1dorsal/ventral pattern formationGO:000995310.2NOG, SHH
2lung morphogenesisGO:006042510.2NOG, SHH
3somite developmentGO:006105310.2NOG, SHH
4anatomical structure formation involved in morphogenesisGO:004864610.1NOG, SHH
5negative regulation of cell differentiationGO:004559610.1NOG, SHH
6canonical Wnt signaling pathwayGO:006007010.0PTEN, SHH
7embryonic hindlimb morphogenesisGO:003511610.0CHD7, SHH
8heart loopingGO:00019479.9SHH, ZIC3
9embryonic skeletal system developmentGO:00487069.9NOG, SHH
10camera-type eye developmentGO:00430109.9CHD7, SHH
11forebrain developmentGO:00309009.9NOG, SHH
12somatic stem cell population maintenanceGO:00350199.8NOG, ZIC3
13lung developmentGO:00303249.7SHH, ZIC3
14embryonic limb morphogenesisGO:00303269.6HOXD13, SHH
15locomotory behaviorGO:00076269.6CHD7, PTEN
16male genitalia developmentGO:00305399.5HOXD13, SHH
17palate developmentGO:00600219.5CHD7, SHH
18limb developmentGO:00601739.5CHD7, NOG, SHH
19negative regulation of cell migrationGO:00303369.5NOG, PTEN, SHH
20embryonic digit morphogenesisGO:00427339.2HOXD13, NOG, SHH
21determination of left/right symmetryGO:00073689.1SHH, ZIC3
22anterior/posterior pattern specificationGO:00099529.0HOXD13, SHH, ZIC3
23pattern specification processGO:00073898.7HOXD13, NOG, SHH, ZIC3
24central nervous system developmentGO:00074178.6CHD7, NOG, PTEN, SHH
25skeletal system developmentGO:00015018.6CHD7, HOXD13, NOG
26positive regulation of transcription from RNA polymerase II promoterGO:00459448.2HOXD13, NOG, SHH, ZIC3

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.5CHD7, HOXD13, ZIC3

Sources for Tracheoesophageal Fistula

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet