MCID: TRC040
MIFTS: 41

Tracheoesophageal Fistula malady

Category: Rare diseases

Aliases & Classifications for Tracheoesophageal Fistula

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Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 46 25 48
Tracheoesophageal Fistula with or Without Esophageal Atresia 46
 
Te Fistula 46
Tef 46

Classifications:



Summaries for Tracheoesophageal Fistula

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NIH Rare Diseases:46 Tracheoesophageal fistula (tef) is a life-threatening condition in which there is an abnormal connection between the esophagus and trachea (windpipe). the esophagus and trachea run next to each other through the chest cavity. the esophagus carries food and saliva to the stomach, while the trachea carries air to the lungs. tef can lead to severe and fatal lung complications. saliva and gastric secretions can be aspirated into the lungs, and normal swallowing and digestion of food cannot occur. most affected people are diagnosed immediately after birth or during infancy. symptoms may include frothy bubbles of mucus in the mouth and nose; episodes of coughing and choking; and worsening symptoms during feeding. tef may be isolated, or it may occur with other physical or developmental abnormalities (most commonly, esophageal atresia). in many cases the cause is unknown but it has been associated with some chromosome disorders. in some cases it may be acquired later in life after a cancer, infection, ruptured diverticula, or trauma. treatment includes immediate surgical repair with survival rates of almost 100%. last updated: 7/8/2015

MalaCards based summary: Tracheoesophageal Fistula, also known as tracheoesophageal fistula with or without esophageal atresia, is related to imperforate anus and esophageal atresia/tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is SHH (Sonic Hedgehog). Affiliated tissues include trachea, lung and thyroid, and related mouse phenotypes are craniofacial and cellular.

Wikipedia:69 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

Related Diseases for Tracheoesophageal Fistula

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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1imperforate anus29.6CHD7, MYCN, SHH
2esophageal atresia/tracheoesophageal fistula12.5
3pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula12.2
4tracheoesophageal fistula with or without esophageal atresia12.1
5tracheoesophageal fistula symphalangism12.1
6feingold syndrome11.4
7feingold syndrome 211.1
8blaichman syndrome11.1
9esophagitis11.0
10esophageal atresia10.9
11vacterl association10.6
12vater association with macrocephaly and ventriculomegaly10.3
13vacterl association, x-linked10.3
14vater/vacterl association10.3
15laryngitis10.3
16duodenitis10.3
17duodenal atresia10.2
18lymphoma10.2
19tracheomalacia10.2
20esophageal cancer10.2
21tracheal stenosis10.2
22cervicitis10.1
23congenital diaphragmatic hernia10.1
24tracheal agenesis10.1
25mitchell-riley syndrome10.1
26fanconi anemia, complementation group b10.1
27cornelia de lange syndrome 510.1CHD7, SHH
28foramen magnum meningioma10.1MYCN, SHH
29lung cancer10.1
30hypertrophic pyloric stenosis10.1
31pyloric stenosis10.1
32mediastinitis10.1
33right aortic arch10.1
34gastroesophageal reflux10.0
35respiratory failure10.0
36thyroiditis10.0
37laryngeal cleft10.0
38stenosis of lacrimal sac10.0MYCN, SHH
39mismatch repair cancer syndrome10.0MYCN, PTEN
40tricuspid atresia9.9
41aspiration pneumonia9.9
42dermatomyositis9.9
43microcephaly9.9
44heart disease9.9
45congenital heart disease9.9
46pneumonia9.9
47situs inversus9.9
48achalasia9.9
49congenital tracheal stenosis9.9
50dysphagia9.9

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms for Tracheoesophageal Fistula

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Drugs & Therapeutics for Tracheoesophageal Fistula

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Drugs for Tracheoesophageal Fistula (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1threonineNutraceutical17

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endoscopic Closure of Tracheoesophageal Fistulas With Occluder DeviceTerminatedNCT01153061Phase 4
2Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesRecruitingNCT01467245
3Trichloroacetic Acid for Endoscopic Tracho-esophageal Fistula RepairRecruitingNCT01287312
4National Register of Oesophageal AtresiaRecruitingNCT02883725
5A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 MonthsEnrolling by invitationNCT02364843
6Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Genetic tests related to Tracheoesophageal Fistula:

id Genetic test Affiliating Genes
1 Tracheoesophageal Fistula25

Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

34
Trachea, Lung, Thyroid, Colon, Bone, Heart, Testes

Animal Models for Tracheoesophageal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

39 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CHD7, MYCN, SHH, ZIC3
2MP:00053848.3CHD7, MYCN, PTEN, SHH, ZIC3
3MP:00053888.3CHD7, MYCN, PTEN, SHH, ZIC3
4MP:00053678.3HOXD13, MYCN, PTEN, SHH
5MP:00036318.1CHD7, MYCN, PTEN, SHH, ZIC3
6MP:00053698.1CHD7, HOXD13, MYCN, PTEN, SHH
7MP:00053858.1CHD7, MYCN, PTEN, SHH, ZIC3
8MP:00053867.8CHD7, MYCN, PTEN, SHH, ZIC3
9MP:00053897.5CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
10MP:00053807.5CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
11MP:00053817.4CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
12MP:00107687.3CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
13MP:00053917.2CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
14MP:00053787.1CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
15MP:00053907.1CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3
16MP:00053716.8CHD7, HOXD13, MYCN, PTEN, SHH, ZIC3

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 607)
idTitleAuthorsYear
1
Late presenting iatrogenic tracheoesophageal fistula. (26936836)
2016
2
Thoracoscopic Esophageal Atresia with Tracheoesophageal Fistula Repair: The First Iranian Group Report, Passing the Learning Curve. (27471677)
2016
3
Endoscopic closure of tracheoesophageal fistula with submucosal dissection and a biosynthetic mesh. (26115391)
2015
4
Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula. (26475129)
2015
5
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
6
Thoracoscopic versus open repair of esophageal atresia with tracheoesophageal fistula at a single institution. (25052256)
2014
7
Recurrent tracheoesophageal fistula. (23720208)
2013
8
Thoracoscopic treatment of congenital esophageal stenosis in combination with H-type tracheoesophageal fistula. (22901927)
2012
9
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
10
Congenital tracheoesophageal fistula. (22272674)
2012
11
Congenital pulmonary airway malformation (CPAM) [congenital cystic adenomatoid malformation] associated with tracheoesophageal fistula and agensesis of the corpus callosum. (22414029)
2012
12
Slide tracheoplasty in an infant with congenital tracheal stenosis and oesophageal atresia with tracheoesophageal fistula. (22689186)
2012
13
Usefulness of dextranomer/hyaluronic acid copolymer in bronchoscopic treatment of recurrent tracheoesophageal fistula in children. (21782257)
2011
14
Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer. (21769294)
2011
15
Difficult airway caused by remnant tracheal cleft after tracheoesophageal fistula repair. (21441791)
2011
16
Incidence, diagnosis, and outcomes of vocal fold immobility after esophageal atresia (EA) and/or tracheoesophageal fistula (TEF) repair. (22169990)
2011
17
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
18
An 18-year experience of tracheoesophageal fistula and esophageal atresia. (21189942)
2010
19
Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema. (19908119)
2009
20
Feingold syndome: a rare but important cause of syndromic tracheoesophageal fistula. (17848225)
2007
21
Endoscopic management of recurrent congenital tracheoesophageal fistula: a review of techniques and results. (17408757)
2007
22
Anesthetic management of tracheoesophageal fistula repair in a newborn with hypoplastic left heart syndrome. (16677272)
2006
23
Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. (16818050)
2006
24
Bone morphogenetic protein expression patterns in human esophageal atresia with tracheoesophageal fistula. (16315037)
2006
25
Preoperative catheterization of H-type tracheoesophageal fistula to facilitate its localization and surgical correction. (16544220)
2006
26
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
27
Appendiceal mass in a neonate after surgery for esophageal atresia and tracheoesophageal fistula: report of a case. (15622470)
2005
28
Thoracoscopic repair of H-type tracheoesophageal fistula in the newborn: a technical case report. (15486907)
2004
29
A bifurcated tracheal tube for a neonate with tracheoesophageal fistula. (15108992)
2004
30
Tracheoesophageal fistula caused by ingestion of a caustic substance. (12789756)
2003
31
Recurrent tracheoesophageal fistula after foreign body impaction. (12811481)
2003
32
Management of a difficult malignant tracheoesophageal fistula. (17670152)
2003
33
Management of an acquired tracheoesophageal fistula with a fascial free flap. (12112560)
2002
34
Tracheoesophageal fistula after blunt chest trauma: successful diagnosis by computed tomography. (11028712)
2000
35
Tracheoesophageal fistula caused by a self-expanding esophageal stent. (10215238)
1999
36
Simplifying the Waterston's stratification of infants with tracheoesophageal fistula. (10515532)
1999
37
Esophageal patching for an unsuturable tracheoesophageal fistula. (9845151)
1998
38
Esophageal atresia and tracheoesophageal fistula: success and failure rates in the United Arab Emirates. (9880753)
1998
39
Split pectoralis major flap for massive tracheoesophageal fistula. (9419118)
1997
40
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
41
Prognostic classification for esophageal atresia and tracheoesophageal fistula: Waterston versus Montreal. (9247237)
1997
42
A new variant of esophageal atresia with tracheoesophageal fistula and duodenal atresia: a diagnostic dilemma (9069229)
1997
43
Esophageal duplication cyst with esophageal web and tracheoesophageal fistula. (8811570)
1996
44
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
45
Use of an intratracheal silicone prosthesis (Dumon type) for the treatment of tracheoesophageal fistula due to advanced lung cancer. (8931224)
1996
46
Bronchoscopy and occlusion of tracheoesophageal fistula. (8638821)
1996
47
Radiology rounds. Tracheoesophageal fistula. (7787487)
1995
48
Recurrent tracheoesophageal fistula treated with fibrin glue. (7877030)
1994
49
Tracheoesophageal fistula caused by mycobacterial tuberculosis adenopathy. (8512414)
1993
50
Ectopic unilateral multicystic kidney in infant. Associated anomalies of tracheoesophageal fistula and annular pancreas. (14423160)
1960

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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GO Terms for genes affiliated with Tracheoesophageal Fistula

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Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1limb developmentGO:006017310.1CHD7, SHH
2branching morphogenesis of an epithelial tubeGO:004875410.1MYCN, SHH
3embryonic hindlimb morphogenesisGO:003511610.1CHD7, SHH
4camera-type eye developmentGO:004301010.1CHD7, SHH
5positive regulation of mesenchymal cell proliferationGO:000205310.1MYCN, SHH
6palate developmentGO:006002110.0CHD7, SHH
7canonical Wnt signaling pathwayGO:00600709.9PTEN, SHH
8heart loopingGO:00019479.9SHH, ZIC3
9male genitalia developmentGO:00305399.7HOXD13, SHH
10negative regulation of cell migrationGO:00303369.7PTEN, SHH
11determination of left/right symmetryGO:00073689.6SHH, ZIC3
12embryonic limb morphogenesisGO:00303269.6HOXD13, SHH
13locomotory behaviorGO:00076269.5CHD7, PTEN
14lung developmentGO:00303249.3MYCN, SHH, ZIC3
15positive regulation of transcription, DNA-templatedGO:00458939.3MYCN, SHH, ZIC3
16central nervous system developmentGO:00074179.3CHD7, PTEN, SHH
17embryonic digit morphogenesisGO:00427339.2HOXD13, MYCN, SHH
18anterior/posterior pattern specificationGO:00099529.1HOXD13, SHH, ZIC3
19pattern specification processGO:00073899.0HOXD13, SHH, ZIC3
20positive regulation of cell proliferationGO:00082848.9MYCN, PTEN, SHH
21positive regulation of transcription from RNA polymerase II promoterGO:00459447.3CHD7, HOXD13, MYCN, SHH, ZIC3

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.6CHD7, HOXD13, ZIC3

Sources for Tracheoesophageal Fistula

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet