MCID: TRC040
MIFTS: 44

Tracheoesophageal Fistula malady

Rare diseases category

Aliases & Classifications for Tracheoesophageal Fistula

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Sources:
42NIH Rare Diseases, 44Novoseek
See all sources

Aliases & Descriptions for Tracheoesophageal Fistula:

Name: Tracheoesophageal Fistula 42 44
Esophageal Atresia with or Without Tracheoesophageal Fistula 42
 
Tracheoesophageal Fistula with or Without Esophageal Atresia 42


Classifications:



Summaries for Tracheoesophageal Fistula

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Wikipedia:64 A tracheoesophageal fistula (TEF, or TOF; see spelling differences) is an abnormal connection (fistula)... more...

MalaCards based summary: Tracheoesophageal Fistula, also known as esophageal atresia with or without tracheoesophageal fistula, is related to esophageal atresia and vacterl association, and has symptoms including esophageal atresiaand tracheoesophageal fistula. An important gene associated with Tracheoesophageal Fistula is SHH (sonic hedgehog), and among its related pathways are Cardiac Progenitor Differentiation and Hedgehog signaling events mediated by Gli proteins. The compounds cyclopamine and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include trachea, lung and bone, and related mouse phenotypes are pigmentation and tumorigenesis.

Related Diseases for Tracheoesophageal Fistula

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Diseases related to Tracheoesophageal Fistula via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal atresia32.3NOG, SHH
2vacterl association30.5HOXD13, SHH, LPP
3pallister-hall syndrome30.4SHH, GLI3
4esophagitis11.3
5esophageal atresia/tracheoesophageal fistula10.8
6duodenitis10.6
7laryngitis10.6
8tracheal agenesis without tracheoesophageal fistula10.6
9duodenal atresia10.5
10feingold syndrome10.5
11tracheal stenosis10.5
12tracheomalacia10.5
13esophageal cancer10.5
14congenital diaphragmatic hernia10.5
15tracheal agenesis10.5
16schizencephaly10.4SHH
17lung cancer10.4
18cervicitis10.4
19pancreatic hypoplasia, intestinal atresia, and gallbladder aplasia or hypoplasia, with or without tracheoesophageal fistula10.4
20gastroesophageal reflux10.3
21imperforate anus10.3
22hypertrophic pyloric stenosis10.3
23pyloric stenosis10.3
24respiratory failure10.3
25thyroiditis10.3
26laryngeal cleft10.3
27tracheoesophageal fistula symphalangism10.3
28pulmonary function10.3
29mitchell-riley syndrome10.3
30fanconi anemia, complementation group b10.3
31vacterl association, x-linked10.3
32microcephaly10.3
33situs inversus10.3
34achalasia10.3
35aspiration pneumonia10.3
36congenital heart disease10.3
37dermatomyositis10.3
38mediastinitis10.3
39pneumonia10.3
40congenital tracheal stenosis10.3
41tricuspid atresia10.3
42dysphagia10.3
43coloboma10.2SOX2, CHD7
44ganglioneuroma10.1PTEN, MYCN
45ulna and fibula, absence of, with severe limb deficiency10.1
46microphthalmia, syndromic 310.1
47treacher collins syndrome 110.1
48wegener granulomatosis10.1
49williams-beuren syndrome10.1
50charge syndrome10.1

Graphical network of the top 20 diseases related to Tracheoesophageal Fistula:



Diseases related to tracheoesophageal fistula

Symptoms for Tracheoesophageal Fistula

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HPO human phenotypes related to Tracheoesophageal Fistula:

id Description Frequency HPO Source Accession
1 esophageal atresia HP:0002032
2 tracheoesophageal fistula HP:0002575

Drugs & Therapeutics for Tracheoesophageal Fistula

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Drug clinical trials:

Search ClinicalTrials for Tracheoesophageal Fistula

Search NIH Clinical Center for Tracheoesophageal Fistula

Genetic Tests for Tracheoesophageal Fistula

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Anatomical Context for Tracheoesophageal Fistula

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MalaCards organs/tissues related to Tracheoesophageal Fistula:

31
Trachea, Lung, Bone, Heart, Colon, Thyroid, Testes, Bone marrow, Kidney, Pancreas, Skin, T cells, B cells

Animal Models for Tracheoesophageal Fistula or affiliated genes

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MGI Mouse Phenotypes related to Tracheoesophageal Fistula:

35 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.0GLI3, PTEN, SOX2
2MP:00020068.8SHH, PTEN, SOX2, FANCA
3MP:00053778.8NOG, SHH, GLI3, SOX2, CHD7
4MP:00053948.7PTEN, SOX2, GLI3, NOG, SHH
5MP:00028738.7NOG, SHH, PTEN, SOX2, MYCN
6MP:00053868.5SHH, CHD7, MYCN, SOX2, PTEN
7MP:00030128.2GLI3, MYCN, SOX2, SHH, HOXD13
8MP:00053978.1MYCN, PTEN, FANCA, CHD7, SHH
9MP:00053698.0SHH, SOX2, MYCN, NOG, HOXD13, PTEN
10MP:00053888.0SHH, PTEN, SOX2, MYCN, CHD7, NOG
11MP:00053677.9GLI3, MYCN, PTEN, SHH, HOXD13, NOG
12MP:00053857.8PTEN, NOG, GLI3, CHD7, MYCN, FANCA
13MP:00107717.8SHH, SOX2, NOG, HOXD13, GLI3, PTEN
14MP:00053827.6SHH, NOG, FANCA, CHD7, PTEN, MYCN
15MP:00053717.6MYCN, NOG, GLI3, CHD7, PTEN, SHH
16MP:00053767.3CHD7, SOX2, SHH, MYCN, GLI3, PTEN
17MP:00053817.2PTEN, SOX2, SHH, CHD7, NOG, MYCN
18MP:00036317.1CHD7, PTEN, SOX2, NOG, GLI3, SHH
19MP:00053797.1SOX2, SHH, PTEN, FANCA, GLI3, HOXD13
20MP:00053846.9MYCN, SOX2, PTEN, CHD7, SHH, FANCA
21MP:00053916.8NOG, GLI3, FANCA, CHD7, MYCN, SOX2
22MP:00053906.8HOXD13, NOG, GLI3, FANCA, CHD7, MYCN
23MP:00053806.8SHH, HOXD13, PTEN, SOX2, MYCN, FANCA
24MP:00053786.7MYCN, CHD7, FANCA, GLI3, NOG, HOXD13
25MP:00053896.2NOG, HOXD13, SHH, PTEN, SOX2, MYCN
26MP:00107686.1NOG, GLI3, LPP, FANCA, CHD7, MYCN

Publications for Tracheoesophageal Fistula

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Articles related to Tracheoesophageal Fistula:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Esophageal Dysmotility Is Present Before Surgery in Isolated Tracheoesophageal Fistula. (25493344)
2015
2
A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. (25783403)
2015
3
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
4
Management of a congenital tracheoesophageal fistula in a young Spanish water dog. (24423070)
2014
5
VACTERL (Vertebral Defects, Anal Atresia, Tracheoesophageal Fistula withA Esophageal Atresia, Cardiac Defects, Renal and Limb Anomalies) Association: Disease Spectrum in 25 Patients Ascertained for Their UpperA Limb Involvement. (24210691)
2013
6
A case series study of therapeutic implications of type IIIb4: a rare variant of esophageal atresia and distal tracheoesophageal fistula. (23895955)
2013
7
Video: argon plasma coagulator in a 2-month-old child with tracheoesophageal fistula. (22476825)
2012
8
Thoracoscopic treatment of congenital esophageal stenosis in combination with H-type tracheoesophageal fistula. (22901927)
2012
9
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
10
Selective bilateral bronchial intubation for large, acquired tracheoesophageal fistula. (22474805)
2012
11
Congenital tracheoesophageal fistula. (22272674)
2012
12
Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association. (22639458)
2012
13
Analysis of saliva pepsin level in patients with tracheoesophageal fistula and voice prosthesis complications. (23397763)
2012
14
Usefulness of dextranomer/hyaluronic acid copolymer in bronchoscopic treatment of recurrent tracheoesophageal fistula in children. (21782257)
2011
15
Tracheoesophageal fistula closed by chemoradiotherapy in lung cancer. (21769294)
2011
16
Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistula. (20112230)
2010
17
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
18
Diagnosis of esophageal atresia with tracheoesophageal fistula: is there a need for gastrointestinal contrast? (20056230)
2010
19
Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. (20054858)
2010
20
Esophageal atresia/tracheoesophageal fistula in very low-birth-weight neonates: improved outcomes with staged repair. (20006009)
2009
21
Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema. (19908119)
2009
22
Sternohyoid muscle flap interposition in the treatment of an acquired tracheoesophageal fistula. (19260113)
2009
23
Longitudinal follow-up of bronchial inflammation, respiratory symptoms, and pulmonary function in adolescents after repair of esophageal atresia with tracheoesophageal fistula. (18534205)
2008
24
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
25
Severe stridor following the repair of H-type tracheoesophageal fistula in an 11 month infant. (19235526)
2008
26
Feingold syndome: a rare but important cause of syndromic tracheoesophageal fistula. (17848225)
2007
27
Treatment of tracheoesophageal fistula in a child by using an endoscopic suturing device. (17208241)
2007
28
An unknown second tracheoesophageal fistula: a rare cause of postoperative respiratory failure. (16618307)
2006
29
Anesthetic management of tracheoesophageal fistula repair in a newborn with hypoplastic left heart syndrome. (16677272)
2006
30
Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. (16818050)
2006
31
High-grade congenital esophageal stenosis owing to a membranous diaphragm with tracheoesophageal fistula. (16226967)
2005
32
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
33
Infant with esophageal atresia and tracheoesophageal fistula associated with DiGeorge syndrome. (15303257)
2004
34
An endotracheal/tracheostomy tube technique for the emergency management of a midtracheal tracheoesophageal fistula. (12819001)
2003
35
Tracheoesophageal fistula caused by a self-expanding esophageal stent. (10215238)
1999
36
Simplifying the Waterston's stratification of infants with tracheoesophageal fistula. (10515532)
1999
37
Successful long-term endoscopic closure of a recurrent tracheoesophageal fistula with fibrin glue in a child. (10402124)
1999
38
Esophageal patching for an unsuturable tracheoesophageal fistula. (9845151)
1998
39
Split pectoralis major flap for massive tracheoesophageal fistula. (9419118)
1997
40
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
41
Esophageal duplication cyst with esophageal web and tracheoesophageal fistula. (8811570)
1996
42
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
43
Use of an intratracheal silicone prosthesis (Dumon type) for the treatment of tracheoesophageal fistula due to advanced lung cancer. (8931224)
1996
44
Bronchoscopy and occlusion of tracheoesophageal fistula. (8638821)
1996
45
Radiology rounds. Tracheoesophageal fistula. (7787487)
1995
46
Simple technique for proximal pouch mobilization and circular myotomy in cases of esophageal atresia with tracheoesophageal fistula. (7807338)
1994
47
Recurrent tracheoesophageal fistula treated with fibrin glue. (7877030)
1994
48
Tracheoesophageal fistula caused by mycobacterial tuberculosis adenopathy. (8512414)
1993
49
Esophageal atresia and tracheoesophageal fistula in children. (8374655)
1993
50
Esophageal Atresia/Tracheoesophageal Fistula Overview (20301753)
1993

Variations for Tracheoesophageal Fistula

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Expression for genes affiliated with Tracheoesophageal Fistula

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Search GEO for disease gene expression data for Tracheoesophageal Fistula.

Pathways for genes affiliated with Tracheoesophageal Fistula

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Pathways related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NOG, SOX2
29.7GLI3, SHH
3
Show member pathways
9.7GLI3, SHH
49.1GLI3, PTEN, SHH

Compounds for genes affiliated with Tracheoesophageal Fistula

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Compounds related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 6010.9NOG, SHH
2cycloheximide449.3NOG, MYCN, PTEN
3cisplatin44 50 60 1112.1PTEN, MYCN, FANCA
4retinoic acid44 249.9NOG, MYCN, SOX2, PTEN
5leucine448.9FANCA, MYCN, PTEN

GO Terms for genes affiliated with Tracheoesophageal Fistula

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Cellular components related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.1GLI3, LPP, FANCA, CHD7, MYCN, SOX2

Biological processes related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:006105310.3NOG, SHH
2negative regulation of astrocyte differentiationGO:004871210.2MYCN, NOG
3embryonic skeletal system developmentGO:004870610.2NOG, SHH
4branching morphogenesis of an epithelial tubeGO:004875410.2MYCN, SHH
5neuron fate commitmentGO:004866310.2SOX2, SHH
6dorsal/ventral pattern formationGO:000995310.1NOG, SHH
7pituitary gland developmentGO:002198310.1NOG, SOX2
8limb developmentGO:006017310.1CHD7, NOG
9negative regulation of alpha-beta T cell differentiationGO:004663910.1SHH, GLI3
10hindgut morphogenesisGO:000744210.1GLI3, SHH
11embryonic hindlimb morphogenesisGO:003511610.1SHH, CHD7
12negative regulation of osteoblast differentiationGO:004566810.1SOX2, NOG
13artery developmentGO:006084010.1SHH, GLI3
14inner ear developmentGO:004883910.1SOX2, SHH
15positive regulation of alpha-beta T cell differentiationGO:004663810.1GLI3, SHH
16somatic stem cell maintenanceGO:003501910.1SOX2, NOG
17negative thymic T cell selectionGO:004506010.1SHH, GLI3
18positive regulation of protein import into nucleusGO:004230710.0GLI3, SHH
19embryonic digestive tract morphogenesisGO:004855710.0SHH, GLI3
20tongue developmentGO:004358610.0SOX2, GLI3
21metanephros developmentGO:000165610.0GLI3, SHH
22T cell differentiation in thymusGO:003307710.0GLI3, SHH
23forebrain developmentGO:003090010.0SHH, SOX2
24osteoblast differentiationGO:00016499.9SOX2, NOG
25embryonic skeletal system morphogenesisGO:00487049.9MYCN, GLI3
26branching involved in ureteric bud morphogenesisGO:00016589.9GLI3, SHH
27smoothened signaling pathwayGO:00072249.8SHH, GLI3
28negative regulation of neuron differentiationGO:00456659.8SOX2, GLI3
29negative regulation of epithelial cell proliferationGO:00506809.8PTEN, SOX2
30negative regulation of cell migrationGO:00303369.8NOG, PTEN, SHH
31inner ear morphogenesisGO:00424729.8CHD7, SOX2
32lung developmentGO:00303249.7MYCN, GLI3, SHH
33positive regulation of neuroblast proliferationGO:00020529.7SHH, SOX2, GLI3
34palate developmentGO:00600219.7GLI3, CHD7, SHH
35central nervous system developmentGO:00074179.7SHH, PTEN, CHD7
36odontogenesis of dentin-containing toothGO:00424759.7GLI3, SHH
37in utero embryonic developmentGO:00017019.6GLI3, NOG, CHD7
38wound healingGO:00420609.5NOG, GLI3
39heart developmentGO:00075079.5SHH, GLI3, PTEN
40male genitalia developmentGO:00305399.4HOXD13, SOX2, SHH
41negative regulation of canonical Wnt signaling pathwayGO:00900909.4NOG, SHH, GLI3, SOX2
42canonical Wnt signaling pathwayGO:00600709.4SHH, PTEN
43negative regulation of transcription from RNA polymerase II promoterGO:00001229.3SHH, SOX2, GLI3, NOG
44skeletal system developmentGO:00015019.3NOG, CHD7, HOXD13
45regulation of cell proliferationGO:00421279.3FANCA, SHH, HOXD13
46positive regulation of transcription, DNA-templatedGO:00458939.3GLI3, SHH, SOX2
47anterior/posterior pattern specificationGO:00099529.3GLI3, SHH, HOXD13
48embryonic digit morphogenesisGO:00427338.6HOXD13, SHH, MYCN, GLI3, NOG
49positive regulation of transcription from RNA polymerase II promoterGO:00459448.2NOG, MYCN, SOX2, SHH, HOXD13, GLI3

Molecular functions related to Tracheoesophageal Fistula according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:00037008.4GLI3, MYCN, SOX2, HOXD13
2chromatin bindingGO:00036828.0HOXD13, SOX2, CHD7, GLI3
3protein bindingGO:00055156.5NOG, SHH, PTEN, SOX2, MYCN, CHD7

Sources for Tracheoesophageal Fistula

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet