MCID: TRC008
MIFTS: 64

Trachoma malady

Infectious diseases category

Summaries for Trachoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that results in infection located in eye, has material basis in chlamydia trachomatis (a, b, ba and c serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. the infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards: Trachoma, also known as trachoma, initial stage, is related to conjunctivitis and inclusion conjunctivitis. An important gene associated with Trachoma is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are African trypanosomiasis and Staphylococcus aureus infection. The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and mannitol have been mentioned in the context of this disorder. Affiliated tissues include eye, eye and testes, and related mouse phenotypes are reproductive system and respiratory system.

Wikipedia:63 Trachoma (Greek: τράχωμα, ‘roughness’) also called granular conjunctivitis, Egyptian... more...

Aliases & Classifications for Trachoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

trachoma 8 42 10 44 60
trachoma, initial stage 8 60
trachoma, active stage 8 60
trachoma - active stage 8
trachoma, unspecified 8
active stage trachoma 8
unspecified trachoma 8
trachoma dubium 8
trachoma nos 8


Related Diseases for Trachoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Trachoma:



Diseases related to trachoma

Clinical Features for Trachoma

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Drugs & Therapeutics for Trachoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Trachoma

Drug clinical trials:

Search ClinicalTrials for Trachoma

Search NIH Clinical Center for Trachoma

Search CenterWatch for Trachoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trachoma

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Anatomical Context for Trachoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Trachoma:

32
Eye, Testes, T cells, Spleen, B cells

FMA organs/tissues related to Trachoma:

14
Eye

Animal Models for Trachoma or affiliated genes

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Sources:
36MGI
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Publications for Trachoma

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Sources:
50PubMed
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Articles related to Trachoma:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Special Issue on Trachoma. (24410531)
2014
2
Don't let misinformation derail the trachoma elimination programme. (22496141)
2012
3
SAFE strategy for blinding trachoma addresses sanitation, the other half of MDG7. (22770455)
2012
4
Active trachoma and associated risk factors among children in Baso Liben District of East Gojjam, Ethiopia. (23259854)
2012
5
Solving the trachoma elimination puzzle, one piece at a time. (22192487)
2012
6
Survey of Trachoma within school students in the state of Roraima, Brazil. (21684601)
2011
7
Challenges of trachoma control: an assessment of the situation in northern Nigeria. (21731321)
2011
8
What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence setting. (21693601)
2011
9
Population-based survey of active trachoma in 11 districts of Burundi. (21780872)
2011
10
A cross-sectional survey of water and clean faces in trachoma endemic communities in Tanzania. (21702954)
2011
11
A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates. (21987657)
2011
12
Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops. (21124889)
2010
13
Mapping trachoma in Nasarawa and Plateau States, central Nigeria. (20385526)
2010
14
Trachoma in northern Ghana: a need for further studies. (21090908)
2010
15
Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions. (19744717)
2009
16
Associations between active trachoma and community intervention with Antibiotics, Facial cleanliness, and Environmental improvement (A,F,E). (18446204)
2008
17
Risk factors for active trachoma and Chlamydia trachomatis infection in rural Ethiopia after mass treatment with azithromycin. (18282237)
2008
18
Two doses of azithromycin to eliminate trachoma in a Tanzanian community. (18434662)
2008
19
Trachoma surveillance annual report, 2007. A report by the National Trachoma Surveillance and Reporting Unit. (19374269)
2008
20
Altitude-a risk factor for active trachoma in southern Ethiopia. (17642175)
2007
21
The real challenge: can we discover why trachoma is disappearing before it's gone? (17667276)
2007
22
Comparison of an rRNA-based and DNA-based nucleic acid amplification test for the detection of Chlamydia trachomatis in trachoma. (17050583)
2007
23
Analysis of incidence rates in cluster-randomized trials of interventions against recurrent infections, with an application to trachoma. (16118817)
2005
24
An index of community ocular Chlamydia trachomatis load for control of trachoma. (15653119)
2005
25
Participatory evaluations of trachoma control programmes in eight countries. (16045463)
2005
26
The problem of trachoma within an onchocerciasis-endemic zone in Kaduna: need for a multilateral approach? (16272051)
2005
27
The impact of water supply on trachoma prevalence. (16895035)
2004
28
The evidence base for trachoma interventions. (17491825)
2004
29
Blinding trachoma: a disease of poverty. (15578111)
2004
30
Knowledge and practice related to trachoma among children in Vietnam: a cross-sectional study. (14761835)
2004
31
Face washing promotion for preventing active trachoma. (15266493)
2004
32
New precision in measuring trachoma infection. (12885474)
2003
33
An evaluation of a SAFE-style trachoma control program in central Australia. (12921100)
2003
34
Trachoma among the Yanomami Indians. (12424487)
2002
35
Should trachoma be treated with antibiotics? (11812548)
2002
36
Cost-effectiveness of trachoma control measures: comparing targeted household treatment and mass treatment of children. (11285663)
2001
37
Reduction of trachoma in the absence of antibiotic treatment: evidence from a population-based survey in Malawi. (11471084)
2001
38
Magnitude of trachoma and barriers to uptake of lid surgery in a rural community of northern Nigeria. (11471087)
2001
39
Trachoma: a review. (11434524)
2001
40
New fly trap may reduce prevalence of blindness from trachoma. (11100624)
2000
41
Clinically active trachoma versus actual Chlamydial infection. (10738486)
2000
42
Preventing trachoma through environmental sanitation: a review of the evidence base. (10743299)
2000
43
Topics in international health: trachoma (10906118)
2000
44
A simplified method for immunological typing of trachoma-inclusion conjunctivitis-lymphogranuloma venereum organisms. (16558075)
1973
45
Virulence of trachoma-inclusion conjunctivitis agent after passage in baboons. (4987927)
1970
46
An evaluation of the fluorescent antibody technic in the diagnosis of trachoma and inclusion conjunctivitis. (4923444)
1968
47
Observations on sheep with polyarthritis produced by an agent of the psittacosis-lymphogranuloma venereum-trachoma group. (6066932)
1967
48
Serologic reactions to specific complement-fixing antigens from micro-organisms of the Psittacosis-Lymphogranuloma Venereum-Trachoma (PLT) group. (6025174)
1967
49
GUINEA PIG INCLUSION CONJUNCTIVITIS VIRUS. I. ISOLATION AND IDENTIFICATION AS A MEMBER OF THE PSITTACOSIS-LYMPHOGRANULOMA-TRACHOMA GROUP. (14118043)
1964
50
Infection of rhesus and cynomolgus monkeys with egg-grown viruses of trachoma and inclusion conjunctivitis. (13884031)
1962

Genetic Variations for Trachoma

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Expression for genes affiliated with Trachoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for genes affiliated with Trachoma

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Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Trachoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Trachoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7HSPD1
2mannitol44 1111.5LDHAL6B
3nickel44 2411.4HSPD1
4indoleamine4410.4WARS
5mannan4410.4CD79A, MBL2
6endotoxin4410.3HSPD1
7aspartate4410.3HBB, MBL2, HSPD1
8monomethyl fumarate4410.3IL4, IL10
9p 2774410.2IL10, HSPD1
10estrogen4410.1CD79A, MBL2, S100A7
11rantes4410.1IDO1, MBL2, IL4, IL17A
12prednisolone44 28 1112.1MBL2, CD79A, FGF2
13praziquantel44 1111.1IL4, IL10, CD79A
14polysaccharide4410.0HSPD1, MBL2, CD79A, HP
15polymyxin b4410.0IL4, IL10, MBL2, HSPD1
16polyethylene glycol4410.0HSPD1, CD79A, HP, IL4
17p0024410.0CTGF, HP, IL17A, ENG
18bleomycin44 1111.0HSPD1, CTGF, FGF2, IL4
19ribavirin44 49 1112.0MBL2, HP, IL10, IL4
20okt3449.9CD79A, IL10, IL4
21tuberculin449.9HSPD1, MBL2, CD79A, HP, IL10
22chloroquine44 2 49 28 1113.9IL4, IL10, HP, CD79A
2315-deoxy-delta-12,14-prostaglandin j2449.9CTGF, FGF2, IL10, IL4
24biotin44 11 2411.9IL4, IL10, CD79A, HSPD1
25dexamethasone44 49 28 1112.8ENG, FGF2, CD79A, CTGF, IDO1
26azathioprine44 49 2 1112.8CD79A, HBB, IL10, IL4
27citrate449.8FGF2, HP, CD79A, HSPD1
28fibrinogen449.8HSPD1, MBL2, CTGF, CD79A, HP
29tgf beta1449.8FOXP3, CTGF, FGF2, IL10, ENG
30con a449.8MBL2, CD79A, HP, IL10, IL4
31infliximab44 49 1111.7IDO1, FGF2, IL10, IL4, IL17A
32creatinine449.7HSPD1, MBL2, CTGF, CD79A, HP, IL17A
33cyclosporin a44 28 5911.7FOXP3, CTGF, CD79A, HP, FGF2, IL17A
34sb 20358044 5910.6IL17A, IL4, IL10, FGF2, CTGF
35mannose449.6IL17A, CD79A, MBL2, HSPD1
36oxygen44 2410.6IDO1, S100A7, MBL2, HBB, ENG
37neopterin449.6IDO1, MBL2, CD79A, HP, IL10, IL4
38hyaluronic acid44 2410.6CD79A, HP, FGF2, ENG
39dihydrotestosterone44 28 11 2412.6ENG, IL4, FGF2, CD79A
40lactate449.6HSPD1, CTGF, CD79A, HBB, HP, LDHAL6B
41thyroxine44 2410.5MBL2, CD79A, HP, FGF2, IL10, IL4
42h2o2449.5HSPD1, CTGF, CD79A, HBB, HP, FGF2
43ly294002449.5CTGF, FGF2, IL10, IL4, IL17A
44paraffin449.3HSPD1, MBL2, CD79A, FGF2, IL10, IL4
45thymidine44 2410.3IDO1, CTGF, HBB, FGF2, IL10, IL4
46nitric oxide44 11 2411.3IDO1, MBL2, FOXP3, CTGF, HBB, HP
47cysteine449.2HSPD1, MBL2, CTGF, CD79A, HBB, HP
48oligonucleotide448.9IDO1, CTGF, HLA-DQB1, HBB, IL17A, ENG
49vegf448.7HSPD1, MBL2, CTGF, CD79A, HP, FGF2
50tyrosine448.6HSPD1, IDO1, MBL2, CTGF, HLA-DQB1, HBB

GO Terms for genes affiliated with Trachoma

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16Gene Ontology
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Cellular components related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.8HBB, HP
2external side of plasma membraneGO:0098979.6ENG, IL17A, IL4, CD79A
3extracellular spaceGO:0056158.4ENG, HSPD1, MBL2, CTGF, HP, FGF2

Biological processes related to Trachoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:04600710.3IDO1, FOXP3
2negative regulation of chronic inflammatory responseGO:00267710.3FOXP3, IL4
3negative regulation of interleukin-10 productionGO:03269310.2IDO1, FOXP3
4regulation of isotype switchingGO:04519110.2IL10, IL4
5type 2 immune responseGO:04209210.2IL4, IL10
6positive regulation of cell deathGO:01094210.1HP, HBB, CTGF
7smooth muscle tissue developmentGO:04874510.1ENG, FOXP3
8B cell proliferationGO:04210010.1IL10, CD79A, HSPD1
9positive regulation of MHC class II biosynthetic processGO:04534810.1IL10, IL4
10negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
11lung developmentGO:0303249.9FOXP3, CTGF, FGF2
12B cell differentiationGO:0301839.9CD79A, IL10, IL4
13regulation of phosphorylationGO:0423259.7ENG, IL4
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.6S100A7, CTGF, FGF2
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.3FOXP3, FGF2, IL10, IL4, IL17A, ENG

Molecular functions related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.0HP, HBB
2cytokine activityGO:0051259.5IL17A, IL4, IL10, FGF2
3growth factor activityGO:0080839.2CTGF, FGF2, IL10, IL4

Products for genes affiliated with Trachoma

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  • Antibodies
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  • Antibodies

Sources for Trachoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet