MCID: TRC008
MIFTS: 47

Trachoma malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Trachoma

Aliases & Descriptions for Trachoma:

Name: Trachoma 12 50 52 42 14 69
Trachoma, Initial Stage 69
Trachoma, Active Stage 69
Active Stage Trachoma 12
Trachoma Dubium 12

Classifications:



Summaries for Trachoma

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection located in eye, has material basis in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards based summary : Trachoma, also known as trachoma, initial stage, is related to entropion and onchocerciasis. An important gene associated with Trachoma is KIR2DL3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Azithromycin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells.

Wikipedia : 71 Trachoma is an infectious disease caused by bacterium Chlamydia trachomatis. The infection causes a... more...

Related Diseases for Trachoma

Diseases related to Trachoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 entropion 11.2
2 onchocerciasis 11.2
3 chlamydia 10.5
4 conjunctivitis 10.4
5 inclusion conjunctivitis 10.3
6 lymphogranuloma venereum 10.2
7 hereditary night blindness 10.2 CTGF TNF
8 kernicterus due to isoimmunization 10.2 HLA-C TNF
9 pyridoxal 5'-phosphate-dependent epilepsy 10.1 IL10 TNF
10 tubular renal disease-cardiomyopathy syndrome 10.1 IL10 TNF
11 lagophthalmos 10.1 IL10 TNF
12 multiple vertebral anomalies unusual facies 10.1 IL10 TNF
13 conidiobolomycosis 10.1 IL10 TNF
14 endosalpingiosis 10.1 IL10 TNF
15 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.1 IL10 TNF
16 idiopathic hypertrophic pachymeningitis 10.1 IL10 TNF
17 infantile hypotonia 10.1 IDO1 TNF
18 transient tic disorder 10.1 IL10 TNF
19 vestibule of mouth cancer 10.1 IL10 TNF
20 plantar wart 10.1 IL10 TNF
21 osteodysplasty precocious of danks mayne and kozlowski 10.1 IL10 TNF
22 parkinson disease 11 10.1 IL10 TNF
23 cyclosporiasis 10.1 IL10 TNF
24 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL10 TNF
25 congenital hypothyroidism 10.1 IL10 TNF
26 sarcomatoid transitional cell carcinoma 10.1 IL10 TNF
27 neurotic disorder 10.1 IL10 TNF
28 trichomalacia 10.1 IL10 TNF
29 senile reticular retinal degeneration 10.1 IL10 TNF
30 conduct disorder 10.1 IL10 TNF
31 gastric dilatation 10.1 IL10 TNF
32 pancreatic signet ring cell adenocarcinoma 10.1 IL10 TNF
33 megaloblastic anemia 10.1 IDO1 IL10
34 pulpitis 10.1 IL10 TNF
35 tularemia 10.1 IL10 TNF
36 chronic thromboembolic pulmonary hypertension 10.1 IDO1 IL10
37 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL10 TNF
38 pseudo-meigs syndrome 10.1 IL10 TNF
39 gonococcal endophthalmia 10.0 IL10 TNF
40 ectodermal dysplasia bartalos type 10.0 IL10 TNF
41 primary ciliary dyskinesia 10.0 IL10 TNF
42 cryptococcosis 10.0 IL10 TNF
43 hereditary alpha tryptasemia syndrome 10.0 IL10 TNF
44 rickettsialpox 10.0 IL10 TNF
45 autosomal recessive type iv ehlers-danlos syndrome 10.0 IL10 TNF
46 astrocytoma 10.0 IL10 TNF
47 bladder signet ring cell adenocarcinoma 10.0 IL10 TNF
48 acute myeloid leukemia with recurrent genetic anomaly 10.0 IL10 TNF
49 erb-duchenne and dejerine-klumpke palsies 10.0 IL10 TNF
50 microcephaly 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to Trachoma

Symptoms & Phenotypes for Trachoma

Drugs & Therapeutics for Trachoma

Drugs for Trachoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
5
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
6
Menthol Approved Phase 4 2216-51-5 16666
7 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
8 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
9 Anti-Infective Agents Phase 4
10 Anthelmintics Phase 4
11 Antimitotic Agents Phase 4
12 Antiparasitic Agents Phase 4
13 Antiprotozoal Agents Phase 4
14 Antitubercular Agents Phase 4
15 Ophthalmic Solutions Phase 3
16 Pharmaceutical Solutions Phase 3
17 Tetrahydrozoline Phase 3
18
Fluorometholone Approved 426-13-1 9878
19 Anti-Allergic Agents
20 Anti-Inflammatory Agents
21 glucocorticoids
22 Hormone Antagonists
23 Hormones
24 Hormones, Hormone Substitutes, and Hormone Antagonists
25 Lubricant Eye Drops

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4
2 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
3 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
4 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
5 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4
6 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4
7 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4
8 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4
9 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
10 Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia Completed NCT00347776 Phase 4
11 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4
12 Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children Recruiting NCT02414399 Phase 4
13 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4
14 Mortality Reduction After Oral Azithromycin: Mortality Study Recruiting NCT02047981 Phase 4
15 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Active, not recruiting NCT01767506 Phase 4
16 Water Uptake for Health in Amhara Pilot Active, not recruiting NCT02373657 Phase 4
17 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4
18 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4
19 Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma Completed NCT00356720 Phase 3
20 Nepal Elimination of Trachoma Study Withdrawn NCT02176057 Phase 2, Phase 3
21 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
22 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169
23 Identification of TT Cases by Community Treatment Assistants: An Assessment Completed NCT01783743
24 Fluorometholone as Ancillary Therapy for TT Surgery Completed NCT01949454
25 A Trial of Epilation Verses Surgery for Minor Trichiasis Completed NCT00522912
26 Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze Completed NCT00439114
27 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis Completed NCT01178762
28 The Effect of Long-Term HEAD START Training on Surgical Skill Levels Not yet recruiting NCT03135080
29 Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population Withdrawn NCT02655432 Early Phase 1

Search NIH Clinical Center for Trachoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trachoma

Genetic Tests for Trachoma

Anatomical Context for Trachoma

MalaCards organs/tissues related to Trachoma:

39
Eye, Testes, T Cells, B Cells, Spleen

The Foundational Model of Anatomy Ontology organs/tissues related to Trachoma:

18
Eye

Publications for Trachoma

Articles related to Trachoma:

(show top 50) (show all 668)
id Title Authors Year
1
In Morocco, the elimination of trachoma as a public health problem becomes a reality. ( 28089329 )
2017
2
Prevalence of Trachoma in Schoolchildren in Brazil. ( 27824506 )
2016
3
Cross-Sectional Surveys of the Prevalence of Follicular Trachoma and Trichiasis in The Gambia: Has Elimination Been Reached? ( 27643498 )
2016
4
Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells. ( 27219121 )
2016
5
Trachoma: Past, present and future. ( 27830198 )
2016
6
Trachoma prevalence in rural areas of eastern Iran. ( 27158510 )
2016
7
Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma. ( 27199475 )
2016
8
Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. ( 27391274 )
2016
9
A cluster-randomized trial to assess the efficacy of targeting trachoma treatment to children. ( 27956455 )
2016
10
Low Prevalence of Conjunctival Infection with Chlamydia trachomatis in a Treatment-NaA^ve Trachoma-Endemic Region of the Solomon Islands. ( 27603015 )
2016
11
Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop. ( 27321784 )
2016
12
Erratum to: Short-term forecasting of the prevalence of clinical trachoma: utility of including delayed recovery and tests for infection. ( 27283120 )
2016
13
Prevalence and factors associated with trachoma among children aged 1-9 years in Zala district, Gamo Gofa Zone, Southern Ethiopia. ( 27621585 )
2016
14
Relationship between Community Drug Administration Strategy and Changes in Trachoma Prevalence, 2007 to 2013. ( 27385309 )
2016
15
Australian trachoma surveillance annual report, 2013. ( 27522137 )
2016
16
Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. ( 26888658 )
2016
17
Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages. ( 26912299 )
2016
18
Prevalence of Trachoma in Niger State, North Central Nigeria: Results of 25 Population-Based Prevalence Surveys Carried Out with the Global Trachoma Mapping Project. ( 27918223 )
2016
19
Trachoma. ( 26860629 )
2016
20
The Global Trachoma Mapping Project: A Catalyst for Progress Against Neglected Tropical Diseases. ( 28030282 )
2016
21
The broad benefits of trachoma elimination. ( 27599650 )
2016
22
Sequelae from Epidemic Viral Conjunctivitis Can Be Associated with Inflammatory Trachoma in Schoolchildren? ( 27628039 )
2016
23
The Prevalence of Trachoma in Tigray Region, Northern Ethiopia: Results of 11 Population-Based Prevalence Surveys Completed as Part of the Global Trachoma Mapping Project. ( 27918232 )
2016
24
History of trachoma. ( 27939803 )
2016
25
Historical Aspects of Endemic Trachoma in Peru: 1895-2000. ( 26766118 )
2016
26
Prevalence of and Risk Factors for Trachoma in Southern Nations, Nationalities, and Peoples' Region, Ethiopia: Results of 40 Population-Based Prevalence Surveys Carried Out with the Global Trachoma Mapping Project. ( 27918229 )
2016
27
Enhanced antibiotic distribution strategies and the potential impact of facial cleanliness and environmental improvements for the sustained control of trachoma: a modelling study. ( 27194136 )
2016
28
Arthur Ferguson MacCallan CBE, MD, FRCS (1872-1955), trachoma pioneer and the ophthalmic campaign in Egypt 1903-1923. ( 27316693 )
2016
29
Low Prevalence of Ocular Chlamydia trachomatis Infection and Active Trachoma in the Western Division of Fiji. ( 27404379 )
2016
30
The World Health Organization Recommendations for Trachoma Surveillance, Experience in Nepal and Added Benefit of Testing for Antibodies to Chlamydia trachomatis pgp3 Protein: NESTS Study. ( 27654497 )
2016
31
Prevalence of Trachoma in Benishangul Gumuz Region, Ethiopia: Results of Seven Population-Based Surveys from the Global Trachoma Mapping Project. ( 27918248 )
2016
32
National Trachoma Assessment in the Lao People's Democratic Republic in 2013-2014. ( 27846362 )
2016
33
Elimination of blinding trachoma in China. ( 27865692 )
2016
34
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
35
The impact of climate on the abundance of Musca sorbens, the vector of trachoma. ( 26817815 )
2016
36
Blinding Trachoma: Systematic Review of Rates and Risk Factors for Progressive Disease. ( 27483002 )
2016
37
Trachoma in Indigenous Settlements in Brazil, 2000-2008. ( 27142891 )
2016
38
Elimination of Trachoma-Knowing Where to Intervene. ( 27841722 )
2016
39
Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. ( 27559544 )
2016
40
Rural children active trachoma risk factors and their interactions. ( 27642466 )
2016
41
Population-Based Trachoma Mapping in Six Evaluation Units of Papua New Guinea. ( 27893297 )
2016
42
Prevalence of Trachoma in Gambella Region, Ethiopia: Results of Three Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project. ( 27918222 )
2016
43
Mapping Trachoma in the Solomon Islands: Results of Three Baseline Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project. ( 27937043 )
2016
44
Prevalence of Trachoma in Bauchi State, Nigeria: Results of 20 Local Government Area-Level Surveys. ( 27846369 )
2016
45
The Epidemiology of Trachoma in Darfur States and Khartoum State, Sudan: Results of 32 Population-Based Prevalence Surveys. ( 27841721 )
2016
46
Mapping Trachoma in Kaduna State, Nigeria: Results of 23 Local Government Area-Level, Population-Based Prevalence Surveys. ( 27918227 )
2016
47
Eliminating trachoma: accelerating towards 2020. ( 27601799 )
2016
48
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 27551787 )
2016
49
Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data. ( 27312142 )
2016
50
Can We Use Antibodies to Chlamydia trachomatis as a Surveillance Tool for National Trachoma Control Programs? Results from a District Survey. ( 26771906 )
2016

Variations for Trachoma

Expression for Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for Trachoma

Pathways related to Trachoma according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1 12.21 IDO1 IL10 TNF
2
Show member pathways
12.09 HLA-C IL10 KIR2DL2 KIR2DL3 TNF
3
Show member pathways
11.94 HLA-C KIR2DL2 KIR2DL3 TNF
4
Show member pathways
11.71 HLA-C IL10 TNF
5 11.67 HLA-C KIR2DL2 KIR2DL3
6 11.5 ENG IL10 TNF
7 11.21 IL10 TNF
8 11.2 IL10 TNF
9 11.18 CTGF TNF
10
Show member pathways
11.08 IL10 TNF
11 11 IL10 TNF
12 10.91 IL10 TNF
13 10.8 CTGF ENG
14 10.34 IDO1 IL10 TNF

GO Terms for Trachoma

Biological processes related to Trachoma according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 HLA-C IL10 KIR2DL3 TNF
2 regulation of immune response GO:0050776 9.7 HLA-C KIR2DL2 KIR2DL3
3 negative regulation of gene expression GO:0010629 9.65 CTGF ENG TNF
4 positive regulation of protein phosphorylation GO:0001934 9.63 CTGF ENG TNF
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.57 CTGF TNF
6 negative regulation of T cell proliferation GO:0042130 9.56 IDO1 IL10
7 positive regulation of cytokine secretion GO:0050715 9.55 IL10 TNF
8 negative regulation of mitotic cell cycle GO:0045930 9.54 IL10 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.51 IL10 TNF
10 positive regulation of collagen biosynthetic process GO:0032967 9.49 CTGF ENG
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 IL10 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.37 IL10 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 IL10 TNF
14 endothelial cell apoptotic process GO:0072577 9.26 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 IL10 TNF
16 receptor biosynthetic process GO:0032800 8.96 IL10 TNF
17 extracellular matrix constituent secretion GO:0070278 8.62 CTGF ENG

Sources for Trachoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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