MCID: TRC008
MIFTS: 68

Trachoma malady

Rare diseases, Infectious diseases categories

Summaries for Trachoma

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 A commensal bacterial infectious disease that results in infection located in eye, has material basis in chlamydia trachomatis (a, b, ba and c serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. the infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards: Trachoma, also known as trachoma, initial stage, is related to conjunctivitis and schistosomiasis. An important gene associated with Trachoma is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are amb2 Integrin signaling and Cell adhesion molecules (CAMs). The drugs sulfacetamide and sulfisoxazole diolamine and the compounds tuberculin and con a have been mentioned in the context of this disorder. Affiliated tissues include eye, eye and testes, and related mouse phenotypes are renal/urinary system and craniofacial.

Wikipedia:66 Trachoma (Greek: ???????, ?roughness?) also called granular conjunctivitis, Egyptian ophthalmia, and... more...

Aliases & Classifications for Trachoma

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

trachoma 9 44 11 46 63
trachoma, initial stage 9 63
trachoma, active stage 9 63
trachoma - active stage 9
trachoma, unspecified 9
active stage trachoma 9
unspecified trachoma 9
trachoma dubium 9
trachoma nos 9


Related Diseases for Trachoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Trachoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.3CD79A
2schistosomiasis30.4CD79A, IL10, IL4
3pneumonia30.2IDO1, TNF, IL17A, IL10, MBL2, CD79A
4urethritis30.1CD79A
5arthritis30.0IL17A, TNF
6malaria29.7HLA-B, HLA-DRB1, TNF, HSPD1, HBB, WARS
7blindness10.7
8inclusion conjunctivitis10.7
9lymphogranuloma venereum10.6
10entropion10.4
11onchocerciasis10.3
12listeriosis10.1IDO1
13vulvovaginitis10.1HSPD1
14toxoplasmosis10.1CD79A
15eosinophilia-myalgia syndrome10.1IDO1
16rheumatic congestive heart failure10.1MBL2
17q fever10.1CD79A
18leprosy10.1HLA-DRB1
19typhus10.1WARS
20methemoglobinemia10.1HP
21acute poststreptococcal glomerulonephritis10.1CD79A
22cryptosporidiosis10.1CD79A, MBL2
23aspergillosis10.1MBL2, CD79A
24pemphigus10.1CD79A
25hemoglobinemia10.1HBB, HP
26immunoglobulin g deficiency10.1MBL2, CD79A
27epidermolysis bullosa acquisita10.1CD79A
28sickle cell anemia10.1HBB, HP
29aphthous stomatitis10.1HLA-B
30mesangial proliferative glomerulonephritis10.1MBL2, CD79A
31ophthalmia neonatorum10.1
32dracunculiasis10.1
33cicatricial entropion10.1
34chronic conjunctivitis10.1
35keratoconjunctivitis10.1
36vernal keratoconjunctivitis10.1
37membranoproliferative glomerulonephritis10.1MBL2, CD79A
38hemoglobinopathy10.1HP, HBB
39blau syndrome10.1TNF
40bronchitis10.1MBL2, IL17A, HSPD1
41autoimmune hemolytic anemia10.1HP, CD79A
42membranous glomerulonephritis10.1HP, CD79A, CTGF
43gastritis10.1CD79A, IL17A, HSPD1
44intraocular lymphoma10.1IL10
45allergic bronchopulmonary aspergillosis10.1IL4, MBL2
46multiple sclerosis 110.1HLA-DRB1, HLA-DQB1
47vascular cancer10.1ENG, FGF2
48pemphigus foliaceus10.1HLA-DRB1, CD79A
49nephritis10.1CTGF, CD79A, IL17A
50dermatitis herpetiformis10.1HLA-DQB1, CD79A

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to trachoma

Symptoms for Trachoma

About this section

Drugs & Therapeutics for Trachoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trachoma

Drug clinical trials:

Search ClinicalTrials for Trachoma

Search NIH Clinical Center for Trachoma

Search CenterWatch for Trachoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Trachoma

About this section

Anatomical Context for Trachoma

About this section
Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Trachoma:

34
Eye, Testes, T cells, Spleen, B cells

FMA organs/tissues related to Trachoma:

15
Eye

Animal Models for Trachoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Trachoma:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7HLA-DQB1, HBB, FOXP3, IL4, IL17A, HP
2MP:00053828.4TNF, FOXP3, IL4, IL17A, IL10, ENG
3MP:00028738.3HLA-DQB1, HBB, FOXP3, IL4, IL10, ENG
4MP:00020068.3FGF2, MAPK1, HP, IL10, TNF
5MP:00053818.2HLA-DQB1, TNF, FOXP3, IL4, IL17A, IL10
6MP:00030128.1HLA-B, TNF, FOXP3, IL4, IL17A, IL10
7MP:00053908.0TNF, HBB, IL4, IL17A, IL10, CTGF
8MP:00053918.0TNF, FOXP3, IL4, IL10, CTGF, FGF2
9MP:00053807.9TNF, HSPD1, HBB, IL10, MAPK1, ENG
10MP:00053697.9HLA-DQB1, TNF, HSPD1, IL10, MAPK1, ENG
11MP:00053707.8HLA-DQB1, TNF, HBB, FOXP3, IL4, IL10
12MP:00107717.8TNF, HBB, FOXP3, IL4, IL10, MAPK1
13MP:00053857.4FOXP3, HBB, TNF, HLA-DQB1, IL10, HP
14MP:00053867.4HLA-B, HLA-DQB1, TNF, HSPD1, FOXP3, IL10
15MP:00053887.3HLA-DQB1, TNF, HBB, FOXP3, IL4, IL17A
16MP:00053897.3HLA-DQB1, IDO1, TNF, HSPD1, HBB, FOXP3
17MP:00053787.3HLA-DQB1, TNF, HSPD1, HBB, FOXP3, IL4
18MP:00036316.7HLA-B, HLA-DQB1, TNF, HSPD1, HBB, IL4
19MP:00053846.7FOXP3, HSPD1, TNF, IDO1, HLA-DQB1, IL4
20MP:00053876.5HLA-B, HLA-DQB1, IDO1, TNF, HBB, FOXP3
21MP:00107686.2FOXP3, HBB, HSPD1, TNF, HLA-DQB1, HLA-B
22MP:00053766.1IL4, FOXP3, HBB, TNF, IDO1, HLA-DQB1
23MP:00053975.9FGF2, HLA-B, HLA-DQB1, IDO1, TNF, HBB

Publications for Trachoma

About this section
Sources:
53PubMed
See all sources

Articles related to Trachoma:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Special Issue on Trachoma. (24410531)
2014
2
Trachoma among children in community surveys from four African countries and implications of using school surveys for evaluating prevalence. (24179180)
2013
3
Comparison of trichiasis recurrence after primary bilamellar tarsal rotation or anterior lamellar repositioning surgery performed for trachoma. (23952906)
2013
4
Trachoma in Australia: an update. (23078264)
2013
5
Don't let misinformation derail the trachoma elimination programme. (22496141)
2012
6
The burden of trachoma in South Sudan: assessing the health losses from a condition of graded severity. (22413025)
2012
7
Australian trachoma surveillance annual report, 2010. (23186235)
2012
8
Survey of Trachoma within school students in the state of Roraima, Brazil. (21684601)
2011
9
Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in Tanzania. (21673038)
2011
10
Challenges of trachoma control: an assessment of the situation in northern Nigeria. (21731321)
2011
11
Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities. (20957147)
2010
12
Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops. (21124889)
2010
13
Active trachoma among children in Mali: Clustering and environmental risk factors. (20087414)
2010
14
Targeting antibiotics to households for trachoma control. (21072225)
2010
15
Barriers to the implementation of the SAFE strategy to combat hyperendemic trachoma in Australia. (21090909)
2010
16
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
17
Trachoma survey methods: a literature review. (19274367)
2009
18
Prevalence of active trachoma two years after control activities. (21326842)
2009
19
Fresh-tissue corneolimbal covering graft for large corneal perforation following childhood trachoma. (19485287)
2009
20
Strategies to control trachoma. (19496626)
2009
21
Prevalence of trachoma in Aboriginal communities in the Katherine Region of the Northern Territory in 2007. (18837687)
2008
22
An eye for inequality: how trachoma relates to poverty in Tanzania and Vietnam. (17994437)
2007
23
The 'ngisipet' and trachoma prevention: solving the latrine problem in nomadic tribes. (18330442)
2007
24
Preliminary evidence that synanthropic flies contribute to the transmission of trachoma- causing Chlamydia trachomatis in Latin America. (17572818)
2007
25
Prevalence of trachoma-related trichiasis and corneal opacity in rural Myanmar: the Meiktila Eye Study. (17467521)
2007
26
The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection. (16495527)
2006
27
Recent advances in the global effort to eradicate trachoma. (16770156)
2006
28
Simplification and improvement of height-based azithromycin treatment for paediatric trachoma. (15550255)
2005
29
Acceptability of azithromycin for the control of trachoma in Northern Tanzania. (15979657)
2005
30
Trachoma. (16170104)
2005
31
Seasonal effects in the elimination of trachoma. (15827288)
2005
32
Trachoma still ignored in developing countries. (15158649)
2004
33
New steps toward eliminating blinding trachoma. (15525727)
2004
34
What's new in trachoma control? (17491820)
2004
35
Trachoma: a review. (14620420)
2003
36
Trachoma, flies and environmental factors in Burkina Faso. (12886807)
2003
37
The effect of antibiotic treatment on active trachoma and ocular Chlamydia trachomatis infection. (15482115)
2003
38
Trachoma. (12230687)
2002
39
Assessment of trachoma prevalence in a mobile population in Central Australia. (11471079)
2001
40
Trial of Trachoma Rapid Assessment in a subdistrict of northern Nigeria. (11471094)
2001
41
Determinants of trachoma endemicity using Chlamydia trachomatis ompA DNA sequencing. (11377206)
2001
42
Progression of active trachoma to scarring in a cohort of Tanzanian children. (11471083)
2001
43
Review of the evidence base for the 'F' and 'E' components of the SAFE strategy for trachoma control. (10995092)
2000
44
A targeted, single-dose azithromycin strategy for trachoma. (10772587)
2000
45
Eradication of trachoma worldwide. (10535853)
1999
46
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
47
Antigenic specificity of human antibody to chlamydia in trachoma and lymphogranuloma venereum. (2433383)
1986
48
Isolation and identification of trachoma and inclusion conjunctivitis agents in Melbourne, 1966 to 1972. (4351871)
1973
49
A simplified method for immunological typing of trachoma-inclusion conjunctivitis-lymphogranuloma venereum organisms. (16558075)
1973
50
Serological relationship of trachoma, psittacosis and lymphogranuloma venereum viruses. (13845952)
1960

Variations for Trachoma

About this section

Expression for genes affiliated with Trachoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for genes affiliated with Trachoma

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 5Cell Signaling Technology, 56Reactome
See all sources

Pathways related to Trachoma according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TNF, HP, CTGF
29.4HLA-DRB1, HLA-DQB1, HLA-B
3
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.3MAPK1, HLA-DRB1, HLA-DQB1
4
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3TNF, FOXP3, IL4
5
Show member pathways
9.2IL10, FOXP3, TNF
69.2HLA-B, HLA-DQB1, HLA-DRB1, MBL2
7
Show member pathways
IL27-mediated signaling events39
9.2TNF, IL17A, IL10
89.1HLA-DRB1, TNF, IL4
99.1MBL2, IL10, HLA-DRB1, HLA-DQB1
109.1IL10, HBB, TNF
11
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.1HLA-DQB1, HLA-DRB1, MAPK1, CD79A
12
Show member pathways
9.0IL4, MAPK1, CTGF, FGF2
139.0TNF, IL4, IL10
149.0FGF2, MAPK1, TNF
159.0IDO1, FOXP3, IL4, IL10, CD79A
169.0HLA-DQB1, HLA-DRB1, TNF, IL17A
179.0HLA-B, HLA-DQB1, HLA-DRB1, IL10
189.0MAPK1, IL4, TNF
198.9IL10, HBB, TNF, IDO1
20
Show member pathways
8.9MAPK1, HLA-DRB1, HLA-DQB1, HLA-B
218.9MAPK1, IL10, TNF
22
Show member pathways
8.8HLA-B, HLA-DQB1, HLA-DRB1, CD79A, FGF2
238.8HLA-B, HLA-DQB1, HLA-DRB1, TNF
24
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.7TNF, IL4, MAPK1, CD79A
258.7HLA-DRB1, TNF, IL4, IL10
26
Show member pathways
Immune response CD16 signaling in NK cells61
8.5HLA-B, TNF, IL4, MAPK1
27
Show member pathways
8.5HLA-DQB1, HLA-DRB1, MAPK1, CD79A, CTGF, FGF2
28
Show member pathways
8.5TNF, IL4, IL10, CTGF, FGF2
29
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.3TNF, IL17A, IL10, MAPK1, FGF2
30
Show member pathways
8.3TNF, IL4, IL17A, IL10, MAPK1
31
Show member pathways
8.2HLA-DQB1, HLA-DRB1, TNF, IL10, MAPK1
328.0HLA-DQB1, HLA-DRB1, TNF, HSPD1, IL10, MAPK1
33
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.0TNF, IL4, IL17A, IL10, MAPK1, CD79A
34
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
35
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
36
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
37
Show member pathways
7.9HLA-B, HLA-DQB1, HLA-DRB1, TNF, IL4, MAPK1
38
Show member pathways
7.8HLA-B, HLA-DQB1, HLA-DRB1, TNF, HSPD1, IL4
39
Show member pathways
7.7HLA-DQB1, HLA-DRB1, TNF, IL4, MAPK1, CD79A
40
Show member pathways
7.4MAPK1, HLA-DQB1, HLA-DRB1, TNF, FOXP3, IL4

Compounds for genes affiliated with Trachoma

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB, 30IUPHAR
See all sources

Compounds related to Trachoma according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1tuberculin469.5IL10, CD79A, MBL2, HP, HSPD1
2con a469.3CD79A, HP, MBL2, IL4, IL10
3ribavirin46 52 1211.2IL4, IL10, HLA-B, HP, MBL2
4polysaccharide469.1HSPD1, FGF2, HLA-B, HP, CD79A, MBL2
5interferon gamma469.1TNF, IL4, IL10
6okt3469.1TNF, IL4, CD79A, IL10
7creatinine469.0MBL2, CD79A, CTGF, HSPD1, IL17A, HLA-B
8indoleamine469.0TNF, WARS, IL10, IDO1
9ns 39846 6210.0MAPK1, FGF2, IL17A, TNF
10polymyxin b469.0IL4, TNF, MBL2, IL10, HSPD1
11thyroxine46 2510.0IL4, FGF2, CD79A, MBL2, HP, IL10
12lipoteichoic acid469.0HLA-B, TNF, IL10, MBL2
132,5-oligoadenylate469.0HLA-B, IDO1, TNF, IL10
14chloroquine46 3 52 30 1212.9IL10, TNF, IL4, CD79A, HP
15prednisolone46 30 1210.8TNF, MBL2, CD79A, FGF2, IL10
16polyinosinic-polycytidylic acid468.8HLA-B, IL10, IL4, TNF
17tgf beta1468.8FGF2, TNF, FOXP3, CTGF, ENG, IL10
18ivig468.8CD79A, IL4, IL10, TNF
19fibrinogen468.7HSPD1, MBL2, HLA-B, TNF, HP, CD79A
20endotoxin468.7HP, IL17A, IL10, HLA-B, TNF, HSPD1
21infliximab46 52 1210.7IL10, FGF2, IDO1, IL17A, IL4, TNF
22aspartate468.7HSPD1, HP, IL10, HLA-DQB1, HLA-B, HBB
23lactate468.6HBB, CD79A, CTGF, HSPD1, HLA-B, TNF
24n acetylcysteine468.6TNF, HSPD1, IL4, MAPK1, CD79A, CTGF
25oligonucleotide468.6HLA-DQB1, IDO1, HLA-B, HLA-DRB1, HBB, CTGF
26neopterin468.5TNF, IL4, IL10, HP, IDO1, CD79A
27pd 98,059468.5IL17A, FGF2, TNF, HSPD1, MAPK1, CTGF
28tacrolimus46 52 1210.5IL17A, CD79A, IL10, TNF, IL4, HLA-B
29glutamate468.5IDO1, MAPK1, HLA-DRB1, CD79A, HP, HLA-DQB1
30cysteine468.4HBB, HP, CTGF, CD79A, ENG, MBL2
3115-deoxy-delta-12,14-prostaglandin j2468.4IL4, CTGF, FGF2, IL10, TNF, MAPK1
32paraffin468.4CD79A, HLA-B, HSPD1, FGF2, IL10, MBL2
33rantes468.2IDO1, MBL2, IL4, TNF, HSPD1, HLA-B
34sb 20358046 629.1FGF2, CTGF, IL4, IL17A, IL10, MAPK1
35ly294002468.1FGF2, MAPK1, CTGF, IL10, TNF, IL17A
36actinomycin d468.1TNF, HP, IL4, IL17A, MAPK1, FGF2
37ionomycin468.0TNF, MAPK1, IL10, IL17A, IL4
38h2o2467.9HSPD1, HLA-B, FGF2, CTGF, CD79A, MAPK1
39cycloheximide467.7IDO1, HSPD1, HBB, IL4, IL10, MAPK1
40thymidine46 258.7IL4, FGF2, CTGF, MAPK1, IDO1, IL17A
41cyclosporin a46 30 629.4HSPD1, HLA-B, FOXP3, IL4, IL17A, FGF2
42estrogen467.3S100A7, MAPK1, HP, HBB, IL17A, MBL2
43nitric oxide46 25 129.3HLA-B, MBL2, IDO1, TNF, CTGF, MAPK1
44retinoic acid46 258.3FGF2, S100A7, HLA-B, CTGF, CD79A, TNF
45serine467.2TNF, HBB, HLA-B, FGF2, ENG, CTGF
46oxygen46 258.1ENG, HBB, IDO1, TNF, CTGF, MBL2
47vegf467.0FGF2, TNF, IL4, HSPD1, IL17A, IL10
48pge2466.9IL10, IL17A, MAPK1, IL4, FOXP3, TNF
49tyrosine466.8FGF2, CTGF, ENG, MBL2, MAPK1, HP
50dexamethasone46 52 30 129.4CD79A, ENG, MBL2, MAPK1, HP, IL10

GO Terms for genes affiliated with Trachoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:03183810.0HP, HBB
2MHC class II protein complexGO:0426139.8HLA-DRB1, HLA-DQB1
3endocytic vesicle lumenGO:0716829.7HP, HBB
4integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-DRB1, HLA-DQB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-B, HLA-DQB1, HLA-DRB1
6cell surfaceGO:0099868.9HLA-B, TNF, HSPD1, MBL2, ENG
7external side of plasma membraneGO:0098978.6HLA-DRB1, TNF, IL4, IL17A, ENG, CD79A
8extracellular regionGO:0055767.8TNF, HBB, HP, S100A7, MBL2, CTGF
9extracellular spaceGO:0056157.6FGF2, TNF, HSPD1, IL4, IL17A, IL10
10cytosolGO:0058297.3IDO1, HSPD1, HBB, WARS, MAPK1, S100A7

Biological processes related to Trachoma according to GeneCards/GeneDecks:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:04600710.4IDO1, FOXP3
2negative regulation of interleukin-10 productionGO:03269310.4IDO1, FOXP3
3extracellular matrix constituent secretionGO:07027810.4ENG, CTGF
4negative regulation of chronic inflammatory responseGO:00267710.3FOXP3, IL4
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.2HLA-DRB1, HLA-DQB1
6positive regulation of cell deathGO:01094210.2HBB, HP, CTGF
7humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DQB1, HLA-DRB1
8smooth muscle tissue developmentGO:04874510.1FOXP3, ENG
9lung developmentGO:03032410.0FGF2, CTGF, FOXP3
10regulation of isotype switchingGO:04519110.0IL4, IL10
11type 2 immune responseGO:04209210.0IL10, IL4
12MAPK import into nucleusGO:00018910.0MAPK1, FGF2
13regulation of phosphorylationGO:04232510.0ENG, IL4
14B cell proliferationGO:04210010.0HSPD1, IL10, CD79A
15positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, IL10
16negative regulation of interferon-gamma productionGO:0326899.9IL10, FOXP3, HLA-DRB1
17negative regulation of T cell proliferationGO:0421309.9HLA-DRB1, FOXP3, IL10
18negative regulation of nitric oxide biosynthetic processGO:0450199.9IL10, IL4
19positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL4
20receptor biosynthetic processGO:0328009.8TNF, IL10
21interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DRB1, HLA-DQB1, HLA-B
22negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
23B cell differentiationGO:0301839.7IL4, IL10, CD79A
24defense response to bacteriumGO:0427429.7MBL2, HP, IL10
25detection of bacteriumGO:0160459.7HLA-DRB1, HLA-B
26positive regulation of osteoclast differentiationGO:0456729.6IL17A, TNF
27negative regulation of interleukin-6 productionGO:0327159.6TNF, FOXP3, IL10
28positive regulation of interleukin-10 productionGO:0327339.6IL4, HSPD1
29negative regulation of growth of symbiont in hostGO:0441309.6MBL2, IL10, TNF
30positive regulation of protein phosphorylationGO:0019349.6TNF, ENG, CTGF
31T cell receptor signaling pathwayGO:0508529.5MAPK1, FOXP3, HLA-DRB1, HLA-DQB1
32chemotaxisGO:0069359.3FGF2, MAPK1, IL4
33organ morphogenesisGO:0098879.3FGF2, MAPK1, TNF
34positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3TNF, IL4, IL10
35activation of MAPK activityGO:0001879.3TNF, MAPK1, FGF2
36immune responseGO:0069559.2HLA-B, HLA-DQB1, HLA-DRB1, IL4, IL17A
37positive regulation of ERK1 and ERK2 cascadeGO:0703748.9TNF, S100A7, CTGF, FGF2
38negative regulation of cell proliferationGO:0082858.7TNF, WARS, FOXP3, FGF2
39innate immune responseGO:0450878.4HLA-B, MAPK1, S100A7, MBL2, FGF2
40positive regulation of transcription from RNA polymerase II promoterGO:0459448.4FGF2, TNF, FOXP3, IL4, IL17A, IL10
41positive regulation of transcription, DNA-templatedGO:0458938.4TNF, FOXP3, IL4, IL10, MAPK1, FGF2

Molecular functions related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.8HLA-DRB1, HLA-DQB1
2hemoglobin bindingGO:0304929.7HP, HBB
3growth factor activityGO:0080839.0IL4, IL10, CTGF, FGF2
4cytokine activityGO:0051258.5FGF2, IL10, IL17A, IL4, TNF
5protein bindingGO:0055155.7FOXP3, WARS, HBB, HSPD1, TNF, IL4

Products for genes affiliated with Trachoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trachoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet