MCID: TRC008
MIFTS: 70

Trachoma malady

Rare diseases, Infectious diseases categories
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Summaries for Trachoma

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Disease Ontology:8 A commensal bacterial infectious disease that results in infection located in eye, has material basis in chlamydia trachomatis (a, b, ba and c serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. the infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards based summary: Trachoma, also known as trachoma - active stage, is related to conjunctivitis and urethritis. An important gene associated with Trachoma is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are amb2 Integrin signaling and Cell adhesion molecules (CAMs). The drugs sulfacetamide and sulfisoxazole diolamine and the compounds tuberculin and con a have been mentioned in the context of this disorder. Affiliated tissues include eye, eye and testes, and related mouse phenotypes are renal/urinary system and craniofacial.

Wikipedia:65 Trachoma, also called granular conjunctivitis, Egyptian ophthalmia, and blinding trachoma is an... more...

Aliases & Classifications for Trachoma

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Trachoma, Aliases & Descriptions:

Name: Trachoma 8 42 10 44 62
Trachoma - Active Stage 8 62
Trachoma, Initial Stage 8 62
Trachoma, Active Stage 8 62
Trachoma, Unspecified 8 62
 
Active Stage Trachoma 8
Unspecified Trachoma 8
Trachoma Dubium 8
Trachoma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Related Diseases for Trachoma

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Diseases related to Trachoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1conjunctivitis31.9CD79A
2urethritis30.8CD79A
3schistosomiasis30.5CD79A, IL4, IL10
4arthritis30.1IL17A, TNF
5pneumonia30.0IL17A, IDO1, IL10, MBL2, TNF, CD79A
6malaria29.2HLA-B, HLA-DRB1, TNF, HSPD1, HP, HBB
7blindness10.8
8inclusion conjunctivitis10.7
9listeriosis10.6IDO1
10vulvovaginitis10.6HSPD1
11toxoplasmosis10.6CD79A
12eosinophilia-myalgia syndrome10.6IDO1
13lymphogranuloma venereum10.6
14rheumatic congestive heart failure10.5MBL2
15q fever10.5CD79A
16leprosy10.5HLA-DRB1
17typhus10.5WARS
18methemoglobinemia10.5HP
19entropion10.5
20acute poststreptococcal glomerulonephritis10.5CD79A
21cryptosporidiosis10.5MBL2, CD79A
22aspergillosis10.5CD79A, MBL2
23pemphigus10.5CD79A
24hemoglobinemia10.4HP, HBB
25immunoglobulin g deficiency10.4MBL2, CD79A
26epidermolysis bullosa acquisita10.4CD79A
27aphthous stomatitis10.4HLA-B
28mesangial proliferative glomerulonephritis10.4MBL2, CD79A
29membranoproliferative glomerulonephritis10.4CD79A, MBL2
30hemoglobinopathy10.4HP, HBB
31blau syndrome10.4TNF
32autoimmune hemolytic anemia10.4CD79A, HP
33non-suppurative otitis media10.4HSPD1, MBL2, IL17A
34membranous glomerulonephritis10.4CD79A, HP, CTGF
35gastritis10.4HSPD1, CD79A, IL17A
36allergic bronchopulmonary aspergillosis10.4IL4, MBL2
37vascular cancer10.4ENG, FGF2
38intraocular lymphoma10.4IL10
39multiple sclerosis 110.4HLA-DRB1, HLA-DQB1
40pemphigus foliaceus10.4HLA-DRB1, CD79A
41nephritis10.4CTGF, CD79A, IL17A
42dermatitis herpetiformis10.3CD79A, HLA-DQB1
43immunodeficiency with hyper igm type 110.3CD79A, IL4
44nephrotic syndrome10.3CD79A, HP, IL17A
45glomerulosclerosis10.3ENG, CD79A, CTGF
46omenn syndrome10.3IL4
47bruton-type agammaglobulinemia10.3IL4, CD79A
48paracoccidioidomycosis10.3IL10, HSPD1
49glomerulonephritis10.3CTGF, MBL2, CD79A
50thyroiditis10.3CD79A, HLA-DRB1, MBL2

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to trachoma

Symptoms for Trachoma

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Drugs & Therapeutics for Trachoma

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Drug clinical trials:

Search ClinicalTrials for Trachoma

Search NIH Clinical Center for Trachoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Trachoma

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Anatomical Context for Trachoma

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MalaCards organs/tissues related to Trachoma:

32
Eye, Testes, T cells, Spleen, B cells

FMA organs/tissues related to Trachoma:

14
Eye

Animal Models for Trachoma or affiliated genes

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MGI Mouse Phenotypes related to Trachoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7HLA-DQB1, HBB, FOXP3, IL4, IL17A, HP
2MP:00053828.4TNF, FOXP3, IL4, IL17A, IL10, ENG
3MP:00028738.3HLA-DQB1, HBB, FOXP3, IL4, IL10, ENG
4MP:00020068.3FGF2, MAPK1, HP, IL10, TNF
5MP:00053818.2HLA-DQB1, TNF, FOXP3, IL4, IL17A, IL10
6MP:00030128.1HLA-B, TNF, FOXP3, IL4, IL17A, IL10
7MP:00053908.0TNF, HBB, IL4, IL17A, IL10, CTGF
8MP:00053918.0TNF, FOXP3, IL4, IL10, CTGF, FGF2
9MP:00053807.9TNF, HSPD1, HBB, IL10, MAPK1, ENG
10MP:00053697.9HLA-DQB1, TNF, HSPD1, IL10, MAPK1, ENG
11MP:00053707.8HLA-DQB1, TNF, HBB, FOXP3, IL4, IL10
12MP:00107717.8TNF, HBB, FOXP3, IL4, IL10, MAPK1
13MP:00053857.4FOXP3, HBB, TNF, HLA-DQB1, IL10, HP
14MP:00053867.4HLA-B, HLA-DQB1, TNF, HSPD1, FOXP3, IL10
15MP:00053887.3HLA-DQB1, TNF, HBB, FOXP3, IL4, IL17A
16MP:00053897.3HLA-DQB1, IDO1, TNF, HSPD1, HBB, FOXP3
17MP:00053787.3HLA-DQB1, TNF, HSPD1, HBB, FOXP3, IL4
18MP:00036316.7HLA-B, HLA-DQB1, TNF, HSPD1, HBB, IL4
19MP:00053846.7FOXP3, HSPD1, TNF, IDO1, HLA-DQB1, IL4
20MP:00053876.5HLA-B, HLA-DQB1, IDO1, TNF, HBB, FOXP3
21MP:00107686.2FOXP3, HBB, HSPD1, TNF, HLA-DQB1, HLA-B
22MP:00053766.1IL4, FOXP3, HBB, TNF, IDO1, HLA-DQB1
23MP:00053975.9FGF2, HLA-B, HLA-DQB1, IDO1, TNF, HBB

Publications for Trachoma

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Articles related to Trachoma:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Special Issue on Trachoma. (24410531)
2014
2
Australian Football League clinics promoting health, hygiene and trachoma elimination: the Northern Territory experience. (25282385)
2014
3
Elimination of blinding trachoma by 2020: a call for rapid scale-up and strengthening programmes. (25091024)
2014
4
Trachoma among children in community surveys from four African countries and implications of using school surveys for evaluating prevalence. (24179180)
2013
5
Comparison of trichiasis recurrence after primary bilamellar tarsal rotation or anterior lamellar repositioning surgery performed for trachoma. (23952906)
2013
6
Trachoma in Australia: an update. (23078264)
2013
7
Don't let misinformation derail the trachoma elimination programme. (22496141)
2012
8
The burden of trachoma in South Sudan: assessing the health losses from a condition of graded severity. (22413025)
2012
9
Australian trachoma surveillance annual report, 2010. (23186235)
2012
10
Survey of Trachoma within school students in the state of Roraima, Brazil. (21684601)
2011
11
Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in Tanzania. (21673038)
2011
12
Challenges of trachoma control: an assessment of the situation in northern Nigeria. (21731321)
2011
13
Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities. (20957147)
2010
14
Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops. (21124889)
2010
15
Active trachoma among children in Mali: Clustering and environmental risk factors. (20087414)
2010
16
Targeting antibiotics to households for trachoma control. (21072225)
2010
17
Barriers to the implementation of the SAFE strategy to combat hyperendemic trachoma in Australia. (21090909)
2010
18
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
19
Trachoma survey methods: a literature review. (19274367)
2009
20
Prevalence of active trachoma two years after control activities. (21326842)
2009
21
Fresh-tissue corneolimbal covering graft for large corneal perforation following childhood trachoma. (19485287)
2009
22
Strategies to control trachoma. (19496626)
2009
23
Prevalence of trachoma in Aboriginal communities in the Katherine Region of the Northern Territory in 2007. (18837687)
2008
24
An eye for inequality: how trachoma relates to poverty in Tanzania and Vietnam. (17994437)
2007
25
The 'ngisipet' and trachoma prevention: solving the latrine problem in nomadic tribes. (18330442)
2007
26
Preliminary evidence that synanthropic flies contribute to the transmission of trachoma- causing Chlamydia trachomatis in Latin America. (17572818)
2007
27
Prevalence of trachoma-related trichiasis and corneal opacity in rural Myanmar: the Meiktila Eye Study. (17467521)
2007
28
The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection. (16495527)
2006
29
Recent advances in the global effort to eradicate trachoma. (16770156)
2006
30
Simplification and improvement of height-based azithromycin treatment for paediatric trachoma. (15550255)
2005
31
Acceptability of azithromycin for the control of trachoma in Northern Tanzania. (15979657)
2005
32
Trachoma. (16170104)
2005
33
Seasonal effects in the elimination of trachoma. (15827288)
2005
34
Trachoma still ignored in developing countries. (15158649)
2004
35
New steps toward eliminating blinding trachoma. (15525727)
2004
36
What's new in trachoma control? (17491820)
2004
37
Trachoma: a review. (14620420)
2003
38
Trachoma, flies and environmental factors in Burkina Faso. (12886807)
2003
39
The effect of antibiotic treatment on active trachoma and ocular Chlamydia trachomatis infection. (15482115)
2003
40
Trachoma. (12230687)
2002
41
Assessment of trachoma prevalence in a mobile population in Central Australia. (11471079)
2001
42
Determinants of trachoma endemicity using Chlamydia trachomatis ompA DNA sequencing. (11377206)
2001
43
Review of the evidence base for the 'F' and 'E' components of the SAFE strategy for trachoma control. (10995092)
2000
44
A targeted, single-dose azithromycin strategy for trachoma. (10772587)
2000
45
Eradication of trachoma worldwide. (10535853)
1999
46
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
47
Antigenic specificity of human antibody to chlamydia in trachoma and lymphogranuloma venereum. (2433383)
1986
48
Isolation and identification of trachoma and inclusion conjunctivitis agents in Melbourne, 1966 to 1972. (4351871)
1973
49
A simplified method for immunological typing of trachoma-inclusion conjunctivitis-lymphogranuloma venereum organisms. (16558075)
1973
50
Serological relationship of trachoma, psittacosis and lymphogranuloma venereum viruses. (13845952)
1960

Variations for Trachoma

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Expression for genes affiliated with Trachoma

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Expression patterns in normal tissues for genes affiliated with Trachoma

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Pathways for genes affiliated with Trachoma

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Pathways related to Trachoma according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TNF, HP, CTGF
29.4HLA-DRB1, HLA-DQB1, HLA-B
3
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.3MAPK1, HLA-DRB1, HLA-DQB1
4
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3TNF, FOXP3, IL4
5
Show member pathways
9.2IL10, FOXP3, TNF
69.2HLA-B, HLA-DQB1, HLA-DRB1, MBL2
7
Show member pathways
IL27-mediated signaling events37
9.2TNF, IL17A, IL10
89.1HLA-DRB1, TNF, IL4
99.1MBL2, IL10, HLA-DRB1, HLA-DQB1
109.1IL10, HBB, TNF
11
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.1HLA-DQB1, HLA-DRB1, MAPK1, CD79A
12
Show member pathways
9.0IL4, MAPK1, CTGF, FGF2
139.0TNF, IL4, IL10
149.0FGF2, MAPK1, TNF
159.0IDO1, FOXP3, IL4, IL10, CD79A
169.0HLA-DQB1, HLA-DRB1, TNF, IL17A
179.0HLA-B, HLA-DQB1, HLA-DRB1, IL10
189.0MAPK1, IL4, TNF
198.9IL10, HBB, TNF, IDO1
20
Show member pathways
8.9MAPK1, HLA-DRB1, HLA-DQB1, HLA-B
218.9MAPK1, IL10, TNF
22
Show member pathways
8.8HLA-B, HLA-DQB1, HLA-DRB1, CD79A, FGF2
238.8HLA-B, HLA-DQB1, HLA-DRB1, TNF
24
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.7TNF, IL4, MAPK1, CD79A
258.7HLA-DRB1, TNF, IL4, IL10
26
Show member pathways
Immune response CD16 signaling in NK cells60
8.5HLA-B, TNF, IL4, MAPK1
27
Show member pathways
8.5HLA-DQB1, HLA-DRB1, MAPK1, CD79A, CTGF, FGF2
28
Show member pathways
8.5TNF, IL4, IL10, CTGF, FGF2
29
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.3TNF, IL17A, IL10, MAPK1, FGF2
30
Show member pathways
8.3TNF, IL4, IL17A, IL10, MAPK1
31
Show member pathways
8.2HLA-DQB1, HLA-DRB1, TNF, IL10, MAPK1
328.0HLA-DQB1, HLA-DRB1, TNF, HSPD1, IL10, MAPK1
33
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.0TNF, IL4, IL17A, IL10, MAPK1, CD79A
34
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
35
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
36
Show member pathways
8.0TNF, IL4, IL10, MAPK1, CTGF, FGF2
37
Show member pathways
7.9HLA-B, HLA-DQB1, HLA-DRB1, TNF, IL4, MAPK1
38
Show member pathways
7.8HLA-B, HLA-DQB1, HLA-DRB1, TNF, HSPD1, IL4
39
Show member pathways
7.7HLA-DQB1, HLA-DRB1, TNF, IL4, MAPK1, CD79A
40
Show member pathways
7.4MAPK1, HLA-DQB1, HLA-DRB1, TNF, FOXP3, IL4

Compounds for genes affiliated with Trachoma

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Compounds related to Trachoma according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1tuberculin449.5IL10, CD79A, MBL2, HP, HSPD1
2con a449.3CD79A, HP, MBL2, IL4, IL10
3ribavirin44 50 1111.2IL4, IL10, HLA-B, HP, MBL2
4polysaccharide449.1HSPD1, FGF2, HLA-B, HP, CD79A, MBL2
5interferon gamma449.1TNF, IL4, IL10
6okt3449.1TNF, IL4, CD79A, IL10
7creatinine449.0MBL2, CD79A, CTGF, HSPD1, IL17A, HLA-B
8indoleamine449.0TNF, WARS, IL10, IDO1
9ns 39844 6110.0MAPK1, FGF2, IL17A, TNF
10polymyxin b449.0IL4, TNF, MBL2, IL10, HSPD1
11thyroxine44 2410.0IL4, FGF2, CD79A, MBL2, HP, IL10
12lipoteichoic acid449.0HLA-B, TNF, IL10, MBL2
132,5-oligoadenylate449.0HLA-B, IDO1, TNF, IL10
14chloroquine44 2 50 28 1112.9IL10, TNF, IL4, CD79A, HP
15prednisolone44 28 1110.8TNF, MBL2, CD79A, FGF2, IL10
16polyinosinic-polycytidylic acid448.8HLA-B, IL10, IL4, TNF
17tgf beta1448.8FGF2, TNF, FOXP3, CTGF, ENG, IL10
18ivig448.8CD79A, IL4, IL10, TNF
19fibrinogen448.7HSPD1, MBL2, HLA-B, TNF, HP, CD79A
20endotoxin448.7HP, IL17A, IL10, HLA-B, TNF, HSPD1
21infliximab44 50 1110.7IL10, FGF2, IDO1, IL17A, IL4, TNF
22aspartate448.7HSPD1, HP, IL10, HLA-DQB1, HLA-B, HBB
23lactate448.6HBB, CD79A, CTGF, HSPD1, HLA-B, TNF
24n acetylcysteine448.6TNF, HSPD1, IL4, MAPK1, CD79A, CTGF
25oligonucleotide448.6HLA-DQB1, IDO1, HLA-B, HLA-DRB1, HBB, CTGF
26neopterin448.5TNF, IL4, IL10, HP, IDO1, CD79A
27pd 98,059448.5IL17A, FGF2, TNF, HSPD1, MAPK1, CTGF
28tacrolimus44 50 1110.5IL17A, CD79A, IL10, TNF, IL4, HLA-B
29glutamate448.5IDO1, MAPK1, HLA-DRB1, CD79A, HP, HLA-DQB1
30cysteine448.4HBB, HP, CTGF, CD79A, ENG, MBL2
3115-deoxy-delta-12,14-prostaglandin j2448.4IL4, CTGF, FGF2, IL10, TNF, MAPK1
32paraffin448.4CD79A, HLA-B, HSPD1, FGF2, IL10, MBL2
33rantes448.2IDO1, MBL2, IL4, TNF, HSPD1, HLA-B
34sb 20358044 619.1FGF2, CTGF, IL4, IL17A, IL10, MAPK1
35ly294002448.1FGF2, MAPK1, CTGF, IL10, TNF, IL17A
36actinomycin d448.1TNF, HP, IL4, IL17A, MAPK1, FGF2
37ionomycin448.0TNF, MAPK1, IL10, IL17A, IL4
38h2o2447.9HSPD1, HLA-B, FGF2, CTGF, CD79A, MAPK1
39cycloheximide447.7IDO1, HSPD1, HBB, IL4, IL10, MAPK1
40thymidine44 248.7IL4, FGF2, CTGF, MAPK1, IDO1, IL17A
41cyclosporin a44 28 619.4HSPD1, HLA-B, FOXP3, IL4, IL17A, FGF2
42estrogen447.3S100A7, MAPK1, HP, HBB, IL17A, MBL2
43nitric oxide44 24 119.3HLA-B, MBL2, IDO1, TNF, CTGF, MAPK1
44retinoic acid44 248.3FGF2, S100A7, HLA-B, CTGF, CD79A, TNF
45serine447.2TNF, HBB, HLA-B, FGF2, ENG, CTGF
46oxygen44 248.1ENG, HBB, IDO1, TNF, CTGF, MBL2
47vegf447.0FGF2, TNF, IL4, HSPD1, IL17A, IL10
48pge2446.9IL10, IL17A, MAPK1, IL4, FOXP3, TNF
49tyrosine446.8FGF2, CTGF, ENG, MBL2, MAPK1, HP
50dexamethasone44 50 28 119.4CD79A, ENG, MBL2, MAPK1, HP, IL10

GO Terms for genes affiliated with Trachoma

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Cellular components related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:03183810.0HP, HBB
2MHC class II protein complexGO:0426139.8HLA-DRB1, HLA-DQB1
3endocytic vesicle lumenGO:0716829.7HP, HBB
4integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-DRB1, HLA-DQB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-B, HLA-DQB1, HLA-DRB1
6cell surfaceGO:0099868.9HLA-B, TNF, HSPD1, MBL2, ENG
7external side of plasma membraneGO:0098978.6HLA-DRB1, TNF, IL4, IL17A, ENG, CD79A
8extracellular regionGO:0055767.8TNF, HBB, HP, S100A7, MBL2, CTGF
9extracellular spaceGO:0056157.6FGF2, TNF, HSPD1, IL4, IL17A, IL10
10cytosolGO:0058297.3IDO1, HSPD1, HBB, WARS, MAPK1, S100A7

Biological processes related to Trachoma according to GeneCards/GeneDecks:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:04600710.4IDO1, FOXP3
2negative regulation of interleukin-10 productionGO:03269310.4IDO1, FOXP3
3extracellular matrix constituent secretionGO:07027810.4ENG, CTGF
4negative regulation of chronic inflammatory responseGO:00267710.3FOXP3, IL4
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.2HLA-DRB1, HLA-DQB1
6positive regulation of cell deathGO:01094210.2HBB, HP, CTGF
7humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DQB1, HLA-DRB1
8smooth muscle tissue developmentGO:04874510.1FOXP3, ENG
9lung developmentGO:03032410.0FGF2, CTGF, FOXP3
10regulation of isotype switchingGO:04519110.0IL4, IL10
11type 2 immune responseGO:04209210.0IL10, IL4
12MAPK import into nucleusGO:00018910.0MAPK1, FGF2
13regulation of phosphorylationGO:04232510.0ENG, IL4
14B cell proliferationGO:04210010.0HSPD1, IL10, CD79A
15positive regulation of MHC class II biosynthetic processGO:04534810.0IL4, IL10
16negative regulation of interferon-gamma productionGO:0326899.9IL10, FOXP3, HLA-DRB1
17negative regulation of T cell proliferationGO:0421309.9HLA-DRB1, FOXP3, IL10
18negative regulation of nitric oxide biosynthetic processGO:0450199.9IL10, IL4
19positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL4
20receptor biosynthetic processGO:0328009.8TNF, IL10
21interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DRB1, HLA-DQB1, HLA-B
22negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
23B cell differentiationGO:0301839.7IL4, IL10, CD79A
24defense response to bacteriumGO:0427429.7MBL2, HP, IL10
25detection of bacteriumGO:0160459.7HLA-DRB1, HLA-B
26positive regulation of osteoclast differentiationGO:0456729.6IL17A, TNF
27negative regulation of interleukin-6 productionGO:0327159.6TNF, FOXP3, IL10
28positive regulation of interleukin-10 productionGO:0327339.6IL4, HSPD1
29negative regulation of growth of symbiont in hostGO:0441309.6MBL2, IL10, TNF
30positive regulation of protein phosphorylationGO:0019349.6TNF, ENG, CTGF
31T cell receptor signaling pathwayGO:0508529.5MAPK1, FOXP3, HLA-DRB1, HLA-DQB1
32chemotaxisGO:0069359.3FGF2, MAPK1, IL4
33organ morphogenesisGO:0098879.3FGF2, MAPK1, TNF
34positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3TNF, IL4, IL10
35activation of MAPK activityGO:0001879.3TNF, MAPK1, FGF2
36immune responseGO:0069559.2HLA-B, HLA-DQB1, HLA-DRB1, IL4, IL17A
37positive regulation of ERK1 and ERK2 cascadeGO:0703748.9TNF, S100A7, CTGF, FGF2
38negative regulation of cell proliferationGO:0082858.7TNF, WARS, FOXP3, FGF2
39innate immune responseGO:0450878.4HLA-B, MAPK1, S100A7, MBL2, FGF2
40positive regulation of transcription from RNA polymerase II promoterGO:0459448.4FGF2, TNF, FOXP3, IL4, IL17A, IL10
41positive regulation of transcription, DNA-templatedGO:0458938.4TNF, FOXP3, IL4, IL10, MAPK1, FGF2

Molecular functions related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.8HLA-DRB1, HLA-DQB1
2hemoglobin bindingGO:0304929.7HP, HBB
3growth factor activityGO:0080839.0IL4, IL10, CTGF, FGF2
4cytokine activityGO:0051258.5FGF2, IL10, IL17A, IL4, TNF
5protein bindingGO:0055155.7FOXP3, WARS, HBB, HSPD1, TNF, IL4

Products for genes affiliated with Trachoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Trachoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet