MCID: TRC008
MIFTS: 45

Trachoma

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Trachoma

MalaCards integrated aliases for Trachoma:

Name: Trachoma 12 50 52 42 14 69
Trachoma, Initial Stage 69
Trachoma, Active Stage 69
Active Stage Trachoma 12
Trachoma Dubium 12

Classifications:



Summaries for Trachoma

Disease Ontology : 12 A commensal bacterial infectious disease that results_in infection located in eye, has material basis in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards based summary : Trachoma, also known as trachoma, initial stage, is related to onchocerciasis and entropion. An important gene associated with Trachoma is KIR2DL3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3), and among its related pathways/superpathways are Allograft rejection and Immune response Role of DAP12 receptors in NK cells. The drugs Azithromycin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells.

Wikipedia : 72 Trachoma is an infectious disease caused by bacterium Chlamydia trachomatis. The infection causes a... more...

Related Diseases for Trachoma

Diseases related to Trachoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
id Related Disease Score Top Affiliating Genes
1 onchocerciasis 11.3
2 entropion 11.2
3 rheumatic myocarditis 10.5 CTGF TNF
4 kernicterus due to isoimmunization 10.5 HLA-C TNF
5 chlamydia 10.5
6 hypersomnia 10.5 IDO1 TNF
7 anaerobic meningitis 10.4 HLA-C TNF
8 pure autonomic failure 10.4 IL10 TNF
9 acute ackee fruit intoxication 10.4 IL10 TNF
10 multiple familial trichoepithelioma 10.4 IL10 TNF
11 basidiobolomycosis 10.4 IL10 TNF
12 lagophthalmos 10.4 IL10 TNF
13 type 1 papillary adenoma of the kidney 10.4 IL10 TNF
14 endosalpingiosis 10.4 IL10 TNF
15 idiopathic dilatation of the pulmonary artery 10.4 IL10 TNF
16 ethmoid sinus adenocarcinoma 10.4 IL10 TNF
17 liver leiomyoma 10.4 IL10 TNF
18 plantar wart 10.4 IL10 TNF
19 conjunctivitis 10.4
20 oropharyngeal cancer, childhood 10.4 IL10 TNF
21 spindle cell hemangioma 10.4 IL10 TNF
22 tricho onychic dysplasia 10.4 IL10 TNF
23 alkhurma hemorrhagic fever 10.4 IL10 TNF
24 cyclosporiasis 10.4 IL10 TNF
25 tularemia 10.4 IL10 TNF
26 urethra transitional cell carcinoma 10.4 IL10 TNF
27 early-onset zonular cataract 10.4 IL10 TNF
28 primary biliary cirrhosis 10.4 IL10 TNF
29 hepadnavirus infection 10.4 IL10 TNF
30 senile reticular retinal degeneration 10.4 IL10 TNF
31 chronic graft versus host disease 10.4 IDO1 IL10
32 ulcerative colitis 10.4 IL10 TNF
33 psychologic dyspareunia 10.4 IL10 TNF
34 cryptococcosis 10.4 IL10 TNF
35 megaloblastic anemia 10.3 IL10 TNF
36 inclusion conjunctivitis 10.3
37 dysphagia 10.3 IL10 TNF
38 conduct disorder 10.3 IL10 TNF
39 bartonellosis 10.3 IL10 TNF
40 ovarian mucinous adenofibroma 10.3 IL10 TNF
41 noma 10.3 IL10 TNF
42 acute monoblastic leukemia 10.3 IL10 TNF
43 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.3 IL10 TNF
44 glioblastoma multiforme 10.3 IL10 TNF
45 high pressure neurological syndrome 10.3 IL10 TNF
46 ostertagiasis 10.3 IL10 TNF
47 moderately severe hemophilia b 10.3 IL10 TNF
48 hypospadias 10.3 IL10 TNF
49 plummer's disease 10.3 IL10 TNF
50 residual stage corticosteroid-induced glaucoma 10.3 IL10 TNF

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to Trachoma

Symptoms & Phenotypes for Trachoma

Drugs & Therapeutics for Trachoma

Drugs for Trachoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 53477736 447043
2
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
5
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
6
Menthol Approved Phase 4 2216-51-5 16666
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
8
Sulfamethoxazole Approved Phase 4 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
10 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
11 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
12 Anti-Infective Agents Phase 4
13 Anthelmintics Phase 4
14 Antimitotic Agents Phase 4
15 Antiparasitic Agents Phase 4
16 Antiprotozoal Agents Phase 4
17 Antitubercular Agents Phase 4
18 Antimalarials Phase 4
19 Renal Agents Phase 4
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
21 Ophthalmic Solutions Phase 3
22 Pharmaceutical Solutions Phase 3
23 Tetrahydrozoline Phase 3
24
Fluorometholone Approved 426-13-1 9878
25 Anti-Allergic Agents
26 Anti-Inflammatory Agents
27 glucocorticoids
28 Hormone Antagonists
29 Hormones
30 Hormones, Hormone Substitutes, and Hormone Antagonists
31 Lubricant Eye Drops

Interventional clinical trials:

(show all 31)

id Name Status NCT ID Phase Drugs
1 Partnership for Rapid Elimination of Trachoma Completed NCT00792922 Phase 4 Azithromycin;Azithromycin
2 Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania Completed NCT00347607 Phase 4
3 Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania Completed NCT00347763 Phase 4
4 Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger Completed NCT00348478 Phase 4
5 Trachoma Elimination Follow-up Completed NCT00221364 Phase 4 Mass treatment with oral azithromycin to an entire village
6 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger Completed NCT00618449 Phase 4 Azithromcyin;Azithromycin
7 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
8 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
9 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
10 Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia Completed NCT00347776 Phase 4 azithromycin;topical tetracycline
11 Sanitation, Water, and Instruction in Face-washing for Trachoma Recruiting NCT02754583 Phase 4 Azithromycin;Tetracycline;Albendazole
12 Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children Recruiting NCT02414399 Phase 4 Azithromycin;Placebo
13 Mortality Reduction After Oral Azithromycin: Morbidity Study Recruiting NCT02048007 Phase 4 Azithromycin;Placebo
14 Mortality Reduction After Oral Azithromycin: Mortality Study Recruiting NCT02047981 Phase 4 Azithromycin;Placebo
15 Water Uptake for Health in Amhara Pilot Active, not recruiting NCT02373657 Phase 4
16 Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Active, not recruiting NCT03187834 Phase 4 Azithromycin;Amoxicillin;Cotrimoxazole;Placebo
17 Azithromycin in Control of Trachoma II Withdrawn NCT00286026 Phase 4 Azithromycin
18 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
19 Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma Completed NCT00356720 Phase 3 Azithromycin
20 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Not yet recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
21 Nepal Elimination of Trachoma Study Withdrawn NCT02176057 Phase 2, Phase 3 Azithromycin
22 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial Completed NCT01767506
23 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis Completed NCT01178762 Azithromycin
24 Modified Instrumentation for Surgery to Correct Trichiasis Completed NCT00886015
25 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
26 Identification of TT Cases by Community Treatment Assistants: An Assessment Completed NCT01783743
27 Fluorometholone as Ancillary Therapy for TT Surgery Completed NCT01949454 Fluorometholone 0.1% ophthalmic solution
28 A Trial of Epilation Verses Surgery for Minor Trichiasis Completed NCT00522912
29 Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze Completed NCT00439114
30 The Effect of Long-Term HEAD START Training on Surgical Skill Levels Active, not recruiting NCT03135080
31 Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population Withdrawn NCT02655432 Early Phase 1

Search NIH Clinical Center for Trachoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trachoma

Genetic Tests for Trachoma

Anatomical Context for Trachoma

MalaCards organs/tissues related to Trachoma:

39
Eye, Testes, T Cells, B Cells, Spleen

Publications for Trachoma

Articles related to Trachoma:

(show top 50) (show all 688)
id Title Authors Year
1
The impact of health promotion on trachoma knowledge, attitudes and practice (KAP) of staff in three work settings in remote Indigenous communities in the Northern Territory. ( 28542225 )
2017
2
Spatial clustering of high load ocular Chlamydia trachomatis infection in trachoma: a cross-sectional population-based study. ( 28472466 )
2017
3
Burden of trachoma in five counties of Eastern Equatoria state, South Sudan: Results from population-based surveys. ( 28614375 )
2017
4
Use of validated community-based trachoma trichiasis (TT) case finders to measure the total backlog and detect when elimination threshold is achieved: a TT methodology paper. ( 28819505 )
2017
5
Reduced-cost Chlamydia trachomatis-specific multiplex real-time PCR diagnostic assay evaluated for ocular swabs and use by trachoma research programmes. ( 28487054 )
2017
6
Evaluation of planned bicanalicular nasolacrimal tube retention in treating punctal stenosis or occlusion secondary to trachoma. ( 28641033 )
2017
7
Trachoma in the Democratic Republic of the Congo: Results of 46 Baseline Prevalence Surveys Conducted with the Global Trachoma Mapping Project. ( 28850014 )
2017
8
The Epidemiology of Trachoma in Mozambique: Results of 96 Population-Based Prevalence Surveys. ( 28910562 )
2017
9
Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu. ( 28118354 )
2017
10
Active trachoma and community use of sanitation, Ethiopia. ( 28479620 )
2017
11
Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati. ( 28898240 )
2017
12
Blinding trachoma among Maku Indians of the upper Rio Negro: a neglected public health problem. ( 28832733 )
2017
13
Global survey of mRNA levels and decay rates of Chlamydia trachomatis trachoma and lymphogranuloma venereum biovars. ( 28795162 )
2017
14
Morocco succeeds to eliminate trachoma as a public health problem: World Health Organization. ( 28584542 )
2017
15
Treating village newcomers and travelers for trachoma: Results from ASANTE cluster randomized trial. ( 28662043 )
2017
16
Population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the Casamance region of Senegal. ( 28747198 )
2017
17
The Burden of and Risk Factors for Trachoma in Selected Districts of Zimbabwe: Results of 16 Population-Based Prevalence Surveys. ( 28532208 )
2017
18
Trachomatous Scar Ranking: A Novel Outcome for Trachoma Studies. ( 28719271 )
2017
19
WHO Alliance for the Global Elimination of Trachoma by 2020: progress report on elimination of trachoma, 2014a892016. ( 28664685 )
2017
20
Effectiveness of expanding annual mass azithromycin distribution treatment coverage for trachoma in Niger: a cluster randomised trial. ( 28893761 )
2017
21
Antibiotic Resistance in Young Children in Kilosa District, Tanzania 4 Years after Mass Distribution of Azithromycin for Trachoma Control. ( 28722638 )
2017
22
In Morocco, the elimination of trachoma as a public health problem becomes a reality. ( 28089329 )
2017
23
The Epidemiology of Trachoma in Darfur States and Khartoum State, Sudan: Results of 32 Population-Based Prevalence Surveys. ( 27841721 )
2016
24
Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells. ( 27219121 )
2016
25
Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. ( 26888658 )
2016
26
Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. ( 27559544 )
2016
27
Low Prevalence of Conjunctival Infection with Chlamydia trachomatis in a Treatment-NaA^ve Trachoma-Endemic Region of the Solomon Islands. ( 27603015 )
2016
28
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
29
The Global Trachoma Mapping Project: A Catalyst for Progress Against Neglected Tropical Diseases. ( 28030282 )
2016
30
The Prevalence of Trachoma in Tigray Region, Northern Ethiopia: Results of 11 Population-Based Prevalence Surveys Completed as Part of the Global Trachoma Mapping Project. ( 27918232 )
2016
31
A cluster-randomized trial to assess the efficacy of targeting trachoma treatment to children. ( 27956455 )
2016
32
Relationship between Community Drug Administration Strategy and Changes in Trachoma Prevalence, 2007 to 2013. ( 27385309 )
2016
33
Prevalence of Trachoma in Gambella Region, Ethiopia: Results of Three Population-Based Prevalence Surveys Conducted with the Global Trachoma Mapping Project. ( 27918222 )
2016
34
Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. ( 27391274 )
2016
35
Elimination of blinding trachoma in China. ( 27865692 )
2016
36
Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data. ( 27312142 )
2016
37
The impact of climate on the abundance of Musca sorbens, the vector of trachoma. ( 26817815 )
2016
38
A Cross-Sectional Population-Based Survey of Trachoma among Migrant School Aged Children in Shanghai, China. ( 27610383 )
2016
39
Prevalence of and Risk Factors for Trachoma in Southern Nations, Nationalities, and Peoples' Region, Ethiopia: Results of 40 Population-Based Prevalence Surveys Carried Out with the Global Trachoma Mapping Project. ( 27918229 )
2016
40
Cross-Sectional Surveys of the Prevalence of Follicular Trachoma and Trichiasis in The Gambia: Has Elimination Been Reached? ( 27643498 )
2016
41
Trachoma. ( 26860629 )
2016
42
Trachoma prevalence in rural areas of eastern Iran. ( 27158510 )
2016
43
The World Health Organization Recommendations for Trachoma Surveillance, Experience in Nepal and Added Benefit of Testing for Antibodies to Chlamydia trachomatis pgp3 Protein: NESTS Study. ( 27654497 )
2016
44
Mapping Trachoma in Kaduna State, Nigeria: Results of 23 Local Government Area-Level, Population-Based Prevalence Surveys. ( 27918227 )
2016
45
Trachoma: Past, present and future. ( 27830198 )
2016
46
Population-Based Trachoma Mapping in Six Evaluation Units of Papua New Guinea. ( 27893297 )
2016
47
Enhanced antibiotic distribution strategies and the potential impact of facial cleanliness and environmental improvements for the sustained control of trachoma: a modelling study. ( 27194136 )
2016
48
Prevalence of Trachoma in Benishangul Gumuz Region, Ethiopia: Results of Seven Population-Based Surveys from the Global Trachoma Mapping Project. ( 27918248 )
2016
49
History of trachoma. ( 27939803 )
2016
50
Prevalence of Trachoma in Niger State, North Central Nigeria: Results of 25 Population-Based Prevalence Surveys Carried Out with the Global Trachoma Mapping Project. ( 27918223 )
2016

Variations for Trachoma

Expression for Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for Trachoma

Pathways related to Trachoma according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.84 HLA-C IL10 KIR2DL2 KIR2DL3 KLRC2 TNF
2
Show member pathways
11.83 HLA-C KIR2DL2 KIR2DL3 KLRC2 TNF
3
Show member pathways
11.71 HLA-C IL10 TNF
4 11.67 HLA-C KIR2DL2 KIR2DL3
5 11.52 ENG IL10 KLRC2 TNF
6 11.21 IL10 TNF
7 11.2 IL10 TNF
8 11.18 CTGF TNF
9
Show member pathways
11.08 IL10 TNF
10 11 IL10 TNF
11 10.98 IDO1 IL10 TNF
12 10.91 IL10 TNF
13 10.8 CTGF ENG

GO Terms for Trachoma

Biological processes related to Trachoma according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 HLA-C IL10 KIR2DL3 TNF
2 negative regulation of gene expression GO:0010629 9.7 CTGF ENG TNF
3 regulation of immune response GO:0050776 9.69 HLA-C KIR2DL2 KIR2DL3
4 positive regulation of protein phosphorylation GO:0001934 9.61 CTGF ENG TNF
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.57 CTGF TNF
6 negative regulation of T cell proliferation GO:0042130 9.56 IDO1 IL10
7 negative regulation of mitotic cell cycle GO:0045930 9.55 IL10 TNF
8 positive regulation of cytokine secretion GO:0050715 9.54 IL10 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.49 IL10 TNF
10 positive regulation of collagen biosynthetic process GO:0032967 9.48 CTGF ENG
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 IL10 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.37 IL10 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 IL10 TNF
14 endothelial cell apoptotic process GO:0072577 9.26 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 IL10 TNF
16 receptor biosynthetic process GO:0032800 8.96 IL10 TNF
17 extracellular matrix constituent secretion GO:0070278 8.62 CTGF ENG

Sources for Trachoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....