MCID: TRC008
MIFTS: 64

Trachoma malady

Infectious diseases category

Summaries for Trachoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that results in infection located in eye, has material basis in chlamydia trachomatis (a, b, ba and c serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. the infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards: Trachoma, also known as trachoma, initial stage, is related to conjunctivitis and inclusion conjunctivitis. An important gene associated with Trachoma is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are African trypanosomiasis and Staphylococcus aureus infection. The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and mannitol have been mentioned in the context of this disorder. Affiliated tissues include eye, eye and testes, and related mouse phenotypes are reproductive system and respiratory system.

Wikipedia:63 Trachoma (Greek: τράχωμα, ‘roughness’) also called granular conjunctivitis, Egyptian... more...

Aliases & Classifications for Trachoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

trachoma 8 42 10 44 60
trachoma, initial stage 8 60
trachoma, active stage 8 60
trachoma - active stage 8
trachoma, unspecified 8
active stage trachoma 8
unspecified trachoma 8
trachoma dubium 8
trachoma nos 8


Related Diseases for Trachoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Trachoma:



Diseases related to trachoma

Clinical Features for Trachoma

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Drugs & Therapeutics for Trachoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Trachoma

Drug clinical trials:

Search ClinicalTrials for Trachoma

Search NIH Clinical Center for Trachoma

Search CenterWatch for Trachoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trachoma

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Anatomical Context for Trachoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Trachoma:

32
Eye, Testes, T cells, Spleen, B cells

FMA organs/tissues related to Trachoma:

14
Eye

Animal Models for Trachoma or affiliated genes

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Sources:
36MGI
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Publications for Trachoma

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50PubMed
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Articles related to Trachoma:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Using a Nonparametric Multilevel Latent Markov Model to Evaluate Diagnostics for Trachoma. (23548755)
2013
2
Active trachoma two years after three rounds of azithromycin mass treatment in Cheha district Gurage zone, Southern Ethiopia. (24289535)
2013
3
Methods for estimating population coverage of mass distribution programmes: a review of practices in relation to trachoma control. (22884927)
2012
4
Association between water related factors and active trachoma in Hai district, Northern Tanzania. (23849896)
2012
5
Chlamydial infection during trachoma monitoring: are the most difficult-to-reach children more likely to be infected? (22122734)
2012
6
The cost of antibiotic mass drug administration for trachoma control in a remote area of South Sudan. (22022632)
2011
7
Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities. (20957147)
2010
8
Modelling trachoma for control programmes. (20632535)
2010
9
Mass treatment of trachoma with azithromycin 1.5% eye drops in the Republic of Cameroon: feasibility, tolerance and effectiveness. (19692356)
2010
10
How much is not enough? A community randomized trial of a Water and Health Education programme for Trachoma and Ocular C. trachomatis infection in Niger. (20409284)
2010
11
Comparison of clinical and photographic assessment of trachoma. (19304582)
2009
12
Detection of Chlamydia trachomatis ocular infection in trachoma-endemic communities by rRNA amplification. (18689701)
2009
13
Risk factors for active trachoma in children and trichiasis in adults: a household survey in Amhara Regional State, Ethiopia. (18394663)
2008
14
Onchocerciasis and trachoma control: what has changed in the past two decades? (19030128)
2008
15
The 'ngisipet' and trachoma prevention: solving the latrine problem in nomadic tribes. (18330442)
2007
16
Trachoma control using the who adopted "safe with azithromycin". (17600982)
2007
17
Prevalence of trachoma in school children of remote Western Australian communities between 1992 and 2003. (17362451)
2007
18
Recent advances in the global effort to eradicate trachoma. (16770156)
2006
19
Prevalence of trachoma among a group of Aboriginal school children in remote South Australia. (16925722)
2006
20
Prevalence of trachoma and diabetes-related eye disease among a cohort of adult Aboriginal patients screened over the period 1999-2004 in remote South Australia. (16764652)
2006
21
Elimination of trachoma: are we in danger of being blinded by the randomised controlled trial? (17057171)
2006
22
Clinical examination and laboratory tests for estimation of trachoma prevalence in remote settings. (16377527)
2006
23
Simplification and improvement of height-based azithromycin treatment for paediatric trachoma. (15550255)
2005
24
Active trachoma in children in central Ethiopia: association with altitude. (16107273)
2005
25
Can blinding trachoma be eliminated by 20/20? (16304586)
2005
26
The epidemiology of trachoma in Eastern Equatoria and Upper Nile States, southern Sudan. (16462982)
2005
27
Systemic antibiotics for communitywide trachoma control. (15883291)
2005
28
Mass antibiotic treatment and community protection in trachoma control programs. (15494901)
2004
29
Pesky trachoma suspect finally caught. (15148205)
2004
30
The effect of antibiotic treatment on active trachoma and ocular Chlamydia trachomatis infection. (15482115)
2003
31
What more is there to learn about trachoma? (12714381)
2003
32
Trachoma. (12885486)
2003
33
Eliminating trachoma in areas with limited disease. (12737745)
2003
34
Rationale for mass antibiotic distribution for trachoma elimination. (12189619)
2002
35
Rapid assessment of trachoma in Hainan Province, China: validation of the new World Health Organization methodology. (11821975)
2002
36
Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal. (12145722)
2002
37
Disappearance of trachoma from Western Nepal. (12203176)
2002
38
Antibiotics for trachoma. (11869610)
2002
39
Determinants of trachoma endemicity using Chlamydia trachomatis ompA DNA sequencing. (11377206)
2001
40
Blinding trachoma almost eliminated from Morocco. (11744558)
2001
41
Rapid assessment of trachoma prevalence--Singida, Tanzania. A study to compare assessment methods. (11471078)
2001
42
Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana. (11217675)
2001
43
Three-day course of oral azithromycin vs topical oxytetracycline/polymyxin in treatment of active endemic trachoma. (10974295)
2000
44
Trachoma and water. (17492009)
1999
45
Simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (Chlamydia trachomatis) antigens for use as a screening test for antibody. (1100657)
1975
46
DIRECT AND INDIRECT FLUORESCENT-ANTIBODY TECHNIQUES FOR THE PSITTACOSIS-LYMPHOGRANULOMA VENEREUM-TRACHOMA GROUP OF AGENTS. (14044954)
1963
47
Isolation of trachoma and inclusion conjunctivitis viruses in the United States. (13904378)
1962
48
Serological relationship of trachoma, psittacosis and lymphogranuloma venereum viruses. (13845952)
1960
49
Observations on experimental trachoma and inclusion conjunctivitis. (13372656)
1956
50
Operation for entropion of the upper eyelid in trachoma. (14777854)
1950

Genetic Variations for Trachoma

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Expression for genes affiliated with Trachoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for genes affiliated with Trachoma

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Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Trachoma

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Trachoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7HSPD1
2mannitol44 1111.5LDHAL6B
3nickel44 2411.4HSPD1
4indoleamine4410.4WARS
5mannan4410.4MBL2, CD79A
6endotoxin4410.3HSPD1
7aspartate4410.3HBB, HSPD1, MBL2
8monomethyl fumarate4410.3IL4, IL10
9p 2774410.2IL10, HSPD1
10estrogen4410.1MBL2, S100A7, CD79A
11rantes4410.1IL17A, MBL2, IL4, IDO1
12praziquantel44 1111.1IL10, CD79A, IL4
13prednisolone44 28 1112.1CD79A, FGF2, MBL2
14polysaccharide4410.0MBL2, CD79A, HP, HSPD1
15polymyxin b4410.0IL4, MBL2, IL10, HSPD1
16polyethylene glycol4410.0IL4, HSPD1, HP, CD79A
17p0024410.0HP, IL17A, CTGF, ENG
18bleomycin44 1111.0HSPD1, FGF2, IL4, CTGF
19ribavirin44 49 1112.0MBL2, IL4, IL10, HP
20okt3449.9CD79A, IL10, IL4
21tuberculin449.9CD79A, MBL2, IL10, HP, HSPD1
22chloroquine44 2 49 28 1113.9CD79A, IL4, HP, IL10
2315-deoxy-delta-12,14-prostaglandin j2449.9FGF2, CTGF, IL4, IL10
24biotin44 11 2411.9CD79A, HSPD1, IL4, IL10
25dexamethasone44 49 28 1112.8FGF2, IDO1, CTGF, ENG, CD79A
26azathioprine44 49 2 1112.8IL10, HBB, CD79A, IL4
27fibrinogen449.8HP, HSPD1, MBL2, CTGF, CD79A
28citrate449.8CD79A, HP, FGF2, HSPD1
29tgf beta1449.8ENG, IL10, CTGF, FGF2, FOXP3
30con a449.8CD79A, MBL2, HP, IL10, IL4
31infliximab44 49 1111.7IL10, FGF2, IDO1, IL4, IL17A
32creatinine449.7HP, HSPD1, MBL2, CTGF, CD79A, IL17A
33cyclosporin a44 28 5911.7HP, IL17A, FGF2, CTGF, FOXP3, CD79A
34sb 20358044 5910.6FGF2, CTGF, IL10, IL4, IL17A
35mannose449.6CD79A, MBL2, IL17A, HSPD1
36oxygen44 2410.6ENG, HBB, MBL2, IDO1, S100A7
37neopterin449.6MBL2, IDO1, CD79A, HP, IL4, IL10
38hyaluronic acid44 2410.6ENG, FGF2, HP, CD79A
39dihydrotestosterone44 28 11 2412.6ENG, CD79A, IL4, FGF2
40lactate449.6HBB, HP, LDHAL6B, CTGF, HSPD1, CD79A
41thyroxine44 2410.5HP, IL10, MBL2, CD79A, FGF2, IL4
42h2o2449.5CTGF, FGF2, HP, HSPD1, HBB, CD79A
43ly294002449.5IL17A, CTGF, IL10, FGF2, IL4
44paraffin449.3HSPD1, MBL2, CD79A, IL10, IL4, ENG
45thymidine44 2410.3IL10, FGF2, IL4, IDO1, CTGF, IL17A
46nitric oxide44 11 2411.3IL17A, HBB, IL10, HP, CTGF, FOXP3
47cysteine449.2HP, IL4, ENG, HBB, CTGF, MBL2
48oligonucleotide448.9ENG, IL17A, HBB, CTGF, IDO1, HLA-DQB1
49vegf448.7IL17A, IL10, FGF2, CD79A, CTGF, MBL2
50tyrosine448.6MBL2, IL4, FGF2, HP, HBB, HLA-DQB1

GO Terms for genes affiliated with Trachoma

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16Gene Ontology
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Cellular components related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.8HBB, HP
2external side of plasma membraneGO:0098979.6ENG, IL17A, IL4, CD79A
3extracellular spaceGO:0056158.4ENG, HSPD1, MBL2, CTGF, HP, FGF2

Biological processes related to Trachoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:04600710.3IDO1, FOXP3
2negative regulation of chronic inflammatory responseGO:00267710.3FOXP3, IL4
3negative regulation of interleukin-10 productionGO:03269310.2IDO1, FOXP3
4regulation of isotype switchingGO:04519110.2IL10, IL4
5type 2 immune responseGO:04209210.2IL4, IL10
6positive regulation of cell deathGO:01094210.1HP, HBB, CTGF
7smooth muscle tissue developmentGO:04874510.1ENG, FOXP3
8B cell proliferationGO:04210010.1IL10, CD79A, HSPD1
9positive regulation of MHC class II biosynthetic processGO:04534810.1IL10, IL4
10negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
11lung developmentGO:0303249.9FOXP3, CTGF, FGF2
12B cell differentiationGO:0301839.9CD79A, IL10, IL4
13regulation of phosphorylationGO:0423259.7ENG, IL4
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.6S100A7, CTGF, FGF2
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.3FOXP3, FGF2, IL10, IL4, IL17A, ENG

Molecular functions related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.0HP, HBB
2cytokine activityGO:0051259.5IL17A, IL4, IL10, FGF2
3growth factor activityGO:0080839.2CTGF, FGF2, IL10, IL4

Products for genes affiliated with Trachoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trachoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet