MCID: TRC008
MIFTS: 60

Trachoma malady

Infectious category

Summaries for Trachoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A commensal bacterial infectious disease that results in infection located in eye, has material basis in chlamydia trachomatis (a, b, ba and c serovars), which is transmitted by contact with eye discharge from the infected person and transmitted by congenital method. the infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

MalaCards: Trachoma, also known as trachoma, initial stage, is related to inclusion conjunctivitis and lymphogranuloma venereum. An important gene associated with Trachoma is HSPD1 (heat shock 60kDa protein 1 (chaperonin)), and among its related pathways are African trypanosomiasis and Staphylococcus aureus infection. The drugs sulfacetamide and sulfisoxazole diolamine and the compounds cycloheximide and mannitol have been mentioned in the context of this disorder. Affiliated tissues include eye, whole blood and lymph node, and related mouse phenotypes are reproductive system and respiratory system.

Wikipedia:64 Trachoma (Greek: τράχωμα, ‘roughness’) is an infectious disease caused by the Chlamydia... more...

Aliases & Classifications for Trachoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

trachoma 8 43 10 45 61
trachoma, initial stage 8 61
trachoma, active stage 8 61
trachoma - active stage 8
trachoma, unspecified 8
active stage trachoma 8
unspecified trachoma 8
trachoma dubium 8
trachoma nos 8


Related Diseases for Trachoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Trachoma:



Diseases related to trachoma

Clinical Features for Trachoma

Drugs & Therapeutics for Trachoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trachoma

Drug clinical trials:

Search ClinicalTrials for Trachoma

Search NIH Clinical Center for Trachoma

Search CenterWatch for Trachoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Trachoma

Anatomical Context for Trachoma

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Trachoma:

33
Whole blood, Lymph node, Spleen, Small intestine, Colon, Kidney, Liver, Skin, Uterus, Prostate, Cervix, Tonsil, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

FMA organs/tissues related to Trachoma:

14
Eye

Animal Models for Trachoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Trachoma

Sources:
51PubMed
See all sources

Articles related to Trachoma:

(show top 50)    (show all 1087)
idTitleAuthorsYear
1
Association of Chlamydia trachomatis infection and herpes simplex virus type 2 serostatus with genital human papillomavirus infection in men: the HPV in men study. (23680908)
2013
2
Using a Nonparametric Multilevel Latent Markov Model to Evaluate Diagnostics for Trachoma. (23548755)
2013
3
The geographical distribution and burden of trachoma in Africa. (23951378)
2013
4
Global Alliance for the Elimination of Blinding Trachoma by 2020. (23807967)
2013
5
Clinical and microscopic signs of cervicitis and urethritis: correlation with Chlamydia trachomatis infection in female STI patients. (23460336)
2013
6
Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies. (22801346)
2012
7
Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity. (22581790)
2012
8
In vivo confocal microscopy in scarring trachoma. (21920608)
2011
9
Evaluation of household latrine coverage in Kewot woreda, Ethiopia, 3 years after implementing interventions to control blinding trachoma. (24038498)
2011
10
What is the cost of pelvic inflammatory disease and how much could be prevented by screening for chlamydia trachomatis? Cost analysis of the Prevention of Pelvic Infection (POPI) trial. (21444333)
2011
11
The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma. (20649409)
2010
12
The prevalence of trachoma in Australia: the National Indigenous Eye Health Survey. (20201757)
2010
13
Trachoma control in two Central Australian Aboriginal communities: a case study. (20358257)
2010
14
Chlamydia trachomatis and rubella antibodies in women with full-term deliveries and women with abortion in Baghdad. (20218131)
2009
15
Comparison of clinical and photographic assessment of trachoma. (19304582)
2009
16
Trachoma in Western Equatoria State, Southern Sudan: implications for national control. (19636366)
2009
17
Rapid assessment of trachoma among children living in rural northern India. (19874140)
2009
18
Evaluation of three years of the SAFE strategy (Surgery, Antibiotics, Facial cleanliness and Environmental improvement) for trachoma control in five districts of Ethiopia hyperendemic for trachoma. (19178920)
2009
19
Chlamydia trachomatis ompA variants in trachoma: what do they tell us? (18820750)
2008
20
Chlamydia trachomatis and Chlamydophila abortus induce the expression of secretory leukocyte protease inhibitor in cells of the human female reproductive tract. (19039956)
2008
21
Prevalence of trachoma-related trichiasis and corneal opacity in rural Myanmar: the Meiktila Eye Study. (17467521)
2007
22
Effect of host fatty acid-binding protein and fatty acid uptake on growth of Chlamydia trachomatis L2. (17526850)
2007
23
Taming trachoma. (16904999)
2006
24
Chlamydia trachomatis and herpes simplex virus 2 infection in vulvar intraepithelial neoplasia associated with human papillomavirus. (17009637)
2006
25
Trachoma. (16170104)
2005
26
The Relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). (16088243)
2005
27
Reactive arthritis due to asymptomatic infection of Chlamydia trachomatis. (15942107)
2005
28
Management of trachomatous cicatricial entropion of the upper eye lid: our modified technique. (15929516)
2005
29
Genetic diversity of Chlamydia trachomatis and the prevalence of trachoma. (15014295)
2004
30
Lower level of synovial fluid interferon-gamma in HLA-B27-positive than in HLA-B27-negative patients with Chlamydia trachomatis reactive arthritis. (12626797)
2003
31
Blinding trachoma: prevention with the safe strategy. (14692676)
2003
32
New precision in measuring trachoma infection. (12885474)
2003
33
Eliminating trachoma in areas with limited disease. (12737745)
2003
34
The extended Chlamydia trachomatis diagnosis in patients with pelvic inflammatory disease--a better approach for the diagnosis of upper genital tract infections. (15285188)
2003
35
Assessment of trachoma prevalence in a mobile population in Central Australia. (11471079)
2001
36
The incidence of Chlamydia trachomatis in women with urethral syndrome. (11695072)
2001
37
A survey of trachoma: the histopathology and the mechanism of progressive cicatrization of eyelid tissues. (10859511)
2000
38
Different humoral immune response to Chlamydia trachomatis major outer membrane protein variable domains I and IV in Chlamydia-infected patients with or without reactive arthritis. (10323449)
1999
39
Penetrating keratoplasty in patients with corneal scarring due to trachoma. (10574495)
1999
40
An open label comparative study of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in males and Chlamydia trachomatis cervicitis in female sex workers in an STD clinic in Singapore. (10572491)
1999
41
Identification of immunoreactive proteins of Chlamydia trachomatis by Western blot analysis of a two-dimensional electrophoresis map with patient sera. (10493131)
1999
42
Chlamydia trachomatis antibody detection and diagnosis of reactive arthritis. (9825743)
1998
43
Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion. (9797114)
1998
44
Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (8686573)
1995
45
Serum-specific antibodies for Chlamydia trachomatis in preterm premature rupture of the membranes. (2265800)
1990
46
Diagnosis of mucopurulent cervicitis among women at risk for Chlamydia trachomatis infection. (2472673)
1989
47
Immunoprophylaxis of Chlamydia trachomatis lymphogranuloma venereum pneumonitis in mice by oral immunization. (2917786)
1989
48
The detection of Chlamydia trachomatis by direct immunofluorescence in conjunctival smears from patients with trachoma and patients with ophthalmia neonatorum using a conjugated monoclonal antibody. (3512704)
1986
49
Chlamydia trachomatis as a cause of acute "idiopathic" epididymitis. (622087)
1978
50
Observations on experimental trachoma and inclusion conjunctivitis. (13372656)
1956

Genetic Variations for Trachoma

Expression for genes affiliated with Trachoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Trachoma

Search GEO for disease gene expression data for Trachoma.

Pathways for genes affiliated with Trachoma

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Trachoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Trachoma according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7HSPD1
2mannitol45 1111.5LDHAL6B
3nickel45 2411.4HSPD1
4indoleamine4510.4WARS
5mannan4510.4MBL2, CD79A
6endotoxin4510.3HSPD1
7aspartate4510.3HBB, HSPD1, MBL2
8monomethyl fumarate4510.3IL4, IL10
9p 2774510.2IL10, HSPD1
10estrogen4510.1MBL2, S100A7, CD79A
11rantes4510.1IL17A, MBL2, IL4, IDO1
12praziquantel45 1111.1IL10, CD79A, IL4
13prednisolone45 29 1112.1CD79A, FGF2, MBL2
14polysaccharide4510.0MBL2, CD79A, HP, HSPD1
15polymyxin b4510.0IL4, MBL2, IL10, HSPD1
16polyethylene glycol4510.0IL4, HSPD1, HP, CD79A
17p0024510.0HP, IL17A, CTGF, ENG
18bleomycin45 1111.0HSPD1, FGF2, IL4, CTGF
19ribavirin45 50 1112.0MBL2, IL4, IL10, HP
20okt3459.9CD79A, IL10, IL4
21tuberculin459.9CD79A, MBL2, IL10, HP, HSPD1
22chloroquine45 2 50 29 1113.9CD79A, IL4, HP, IL10
2315-deoxy-delta-12,14-prostaglandin j2459.9FGF2, CTGF, IL4, IL10
24biotin45 11 2411.9CD79A, HSPD1, IL4, IL10
25dexamethasone45 50 29 1112.8FGF2, IDO1, CTGF, ENG, CD79A
26azathioprine45 50 2 1112.8IL10, HBB, CD79A, IL4
27fibrinogen459.8HP, HSPD1, MBL2, CTGF, CD79A
28citrate459.8CD79A, HP, FGF2, HSPD1
29tgf beta1459.8ENG, IL10, CTGF, FGF2, FOXP3
30con a459.8CD79A, MBL2, HP, IL10, IL4
31infliximab45 50 1111.7IL10, FGF2, IDO1, IL4, IL17A
32creatinine459.7HP, HSPD1, MBL2, CTGF, CD79A, IL17A
33cyclosporin a45 29 6011.7HP, IL17A, FGF2, CTGF, FOXP3, CD79A
34sb 20358045 6010.6FGF2, CTGF, IL10, IL4, IL17A
35mannose459.6CD79A, MBL2, IL17A, HSPD1
36oxygen45 2410.6ENG, HBB, MBL2, IDO1, S100A7
37neopterin459.6MBL2, IDO1, CD79A, HP, IL4, IL10
38hyaluronic acid45 2410.6ENG, FGF2, HP, CD79A
39dihydrotestosterone45 29 11 2412.6ENG, CD79A, IL4, FGF2
40lactate459.6HBB, HP, LDHAL6B, CTGF, HSPD1, CD79A
41thyroxine45 2410.5HP, IL10, MBL2, CD79A, FGF2, IL4
42h2o2459.5CTGF, FGF2, HP, HSPD1, HBB, CD79A
43ly294002459.5IL17A, CTGF, IL10, FGF2, IL4
44paraffin459.3HSPD1, MBL2, CD79A, IL10, IL4, ENG
45thymidine45 2410.3IL10, FGF2, IL4, IDO1, CTGF, IL17A
46nitric oxide45 11 2411.3IL17A, HBB, IL10, HP, CTGF, FOXP3
47cysteine459.2HP, IL4, ENG, HBB, CTGF, MBL2
48oligonucleotide458.9ENG, IL17A, HBB, CTGF, IDO1, HLA-DQB1
49vegf458.7IL17A, IL10, FGF2, CD79A, CTGF, MBL2
50tyrosine458.6MBL2, IL4, FGF2, HP, HBB, HLA-DQB1

GO Terms for genes affiliated with Trachoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.8HP, HBB
2external side of plasma membraneGO:0098979.6IL4, CD79A, ENG, IL17A
3extracellular spaceGO:0056158.4ENG, HSPD1, MBL2, CTGF, HP, FGF2

Biological processes related to Trachoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of activated T cell proliferationGO:04600710.3IDO1, FOXP3
2negative regulation of chronic inflammatory responseGO:00267710.3FOXP3, IL4
3negative regulation of interleukin-10 productionGO:03269310.2IDO1, FOXP3
4regulation of isotype switchingGO:04519110.2IL10, IL4
5type 2 immune responseGO:04209210.2IL4, IL10
6positive regulation of cell deathGO:01094210.1HP, HBB, CTGF
7smooth muscle tissue developmentGO:04874510.1ENG, FOXP3
8B cell proliferationGO:04210010.1IL10, CD79A, HSPD1
9positive regulation of MHC class II biosynthetic processGO:04534810.1IL10, IL4
10negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
11lung developmentGO:0303249.9FOXP3, CTGF, FGF2
12B cell differentiationGO:0301839.9CD79A, IL10, IL4
13regulation of phosphorylationGO:0423259.7ENG, IL4
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.6S100A7, CTGF, FGF2
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.3FOXP3, FGF2, IL10, IL4, IL17A, ENG

Molecular functions related to Trachoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.0HP, HBB
2cytokine activityGO:0051259.5IL17A, IL4, IL10, FGF2
3growth factor activityGO:0080839.2CTGF, FGF2, IL10, IL4

Products for genes affiliated with Trachoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trachoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet