TIA
MCID: TRN015
MIFTS: 55

Transient Cerebral Ischemia (TIA) malady

Summaries for Transient Cerebral Ischemia

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to brain ischemia and memory impairment. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are ErbB signaling pathway and Development Glucocorticoid receptor signaling. The compounds glutamate and gnrh have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotype nervous system.

NINDS:44 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:64 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 44NINDS, 34MedlinePlus, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

transient cerebral ischemia 8 10 45 61
transient ischemic attack 8 44 45 34 61
transient cerebral ischaemia nos 8
tia - transient ischaemic attack 8
transient cerebral ischaemia 8
transient ischemic attacks 8
tia 8


External Ids:

Disease Ontology8 DOID:224
MeSH35 D002546
NCIt40 C50781

Related Diseases for Transient Cerebral Ischemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia31.5ADORA1, HSPA4, MAP2, CAMK2G
2memory impairment30.6ADORA1, CDK5, DRD1
3tauopathy30.4CDK5, CAMK2G, RPS27A
4adenoma30.2ODC1, HSPA1A, PLA2G2A
5vascular disease30.2HSPA4, HSPA1A, FOS, MAP2, ADORA1
6cadasil30.2ADORA1, HSPA4, PVALB, ODC1, CAMK2G, MAP2
7mini stroke10.5
8stroke, ischemic10.5
9cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.4
10carotid artery occlusion10.4
11peripheral vascular disease10.3
12deficiency anemia10.3
13iron deficiency anemia10.3
14protein c deficiency10.3
15brain edema10.3
16t cell deficiency10.3
17brain injury10.3
18cerebral hypoxia10.3
19hypoxia10.3
20thrombocythemia 110.3
21moyamoya disease10.2
22carotid stenosis10.2
23vertebrobasilar insufficiency10.2
24antiphospholipid syndrome10.2
25arteriovenous malformation10.2
26prosopagnosia10.2
27systemic lupus erythematosus10.2
28sagittal sinus thrombosis10.2
29petroclival meningioma10.2
30leukostasis10.2
31homocystinuria10.2
32protein s deficiency10.2
33ulcerative colitis10.2
34adult syndrome10.2
35silent myocardial infarction10.2
36acute leukemia10.2
37aphasia10.2
38brain disease10.2
39acute promyelocytic leukemia10.2
40afibrinogenemia10.2
41pulmonary arteriovenous malformation10.2
42carotid body tumor10.2
43eagle syndrome10.2
44left ventricular noncompaction10.2
45phace syndrome10.2
46steroid-resistant nephrotic syndrome10.2
47cytomegalovirus infection10.2
48paresthesia10.2
49venous thrombosis10.2
50patent foramen ovale10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Clinical Features for Transient Cerebral Ischemia

Drugs & Therapeutics for Transient Cerebral Ischemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Transient Cerebral Ischemia

Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Search CenterWatch for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

Anatomical Context for Transient Cerebral Ischemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Transient Cerebral Ischemia:

33
Bone marrow, Whole blood, Spleen, Brain, Cortex, Spinal cord, Thyroid, T cells, B cells, Endothelial, Fetal brain, Olfactory bulb, Fetal thyroid

Animal Models for Transient Cerebral Ischemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Transient Cerebral Ischemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.6ADORA1, HSPA1A, PVALB, FOS, DRD1, SYNGAP1

Publications for Transient Cerebral Ischemia

Sources:
51PubMed
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Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 442)
idTitleAuthorsYear
1
Role of N-Nitro-L-Arginine-Methylester as anti-oxidant in transient cerebral ischemia and reperfusion in rats. (23289587)
2013
2
EGB1212 post-treatment ameliorates hippocampal CA1 neuronal death and memory impairment induced by transient global cerebral ischemia/reperfusion. (24228604)
2013
3
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase. (23032483)
2013
4
EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. (22575539)
2012
5
Expressions of hypoxic stress sensor proteins after transient cerebral ischemia in mice. (22183753)
2012
6
Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. (22717646)
2012
7
Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model. (22099262)
2012
8
Comparison of phosphorylated extracellular signal-regulated kinase 1/2 immunoreactivity in the hippocampal Ca1 region induced by transient cerebral ischemia between adult and aged gerbils. (21191646)
2011
9
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
10
Effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 immunoreactivity and protein levels in the gerbil hippocampus after transient cerebral ischemia. (21190005)
2010
11
The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice. (20796170)
2010
12
Arylalkylamine N-acetyltransferase (AANAT) is expressed in astrocytes and melatonin treatment maintains AANAT in the gerbil hippocampus induced by transient cerebral ischemia. (20488463)
2010
13
Beta-catenin siRNA inhibits ischemia-induced striatal neurogenesis in adult rat brain following a transient middle cerebral artery occlusion. (18343578)
2008
14
Protective effects of deprenyl in transient cerebral ischemia in rats. (19175183)
2008
15
Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia. (18987534)
2008
16
Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia. (16464234)
2006
17
Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male rats. (15353225)
2004
18
Alterations of N-ethylmaleimide-sensitive atpase following transient cerebral ischemia. (15464284)
2004
19
Neuroprotection against transient cerebral ischemia by exercise pre-conditioning in rats. (15198867)
2004
20
Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. (12812761)
2003
21
Editorial comment--Transient cerebral ischemia demands urgent evaluation. (14500925)
2003
22
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. (14559973)
2003
23
Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? (12415119)
2002
24
Protective effects of SM-20302, an orally active GPIIb/IIIa antagonist, in an ADP/epinephrine-induced guinea pig model of transient cerebral ischemia. (11228335)
2001
25
Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. (11487731)
2001
26
Does diffusion-weighted magnetic resonance imaging enable detection of early ischemic change following transient cerebral ischemia? (11099715)
2000
27
Immunocytochemical localization of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS) in rat neurohypophysis after transient cerebral ischemia. (10337059)
1999
28
Altered expression levels of SEF-2 and p112 in the rat hippocampus after transient cerebral ischemia: identification by mRNA differential display. (10197513)
1999
29
Role of the cerebrovascular and metabolic responses in the delayed phases of injury after transient cerebral ischemia in fetal sheep. (10583005)
1999
30
Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. (10529658)
1999
31
Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. (9634557)
1998
32
Neuroprotective effects of preischemia subcutaneous magnesium sulfate in transient cerebral ischemia. (9726620)
1998
33
Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction. (9748529)
1998
34
Temporal and spatial changes of quinolinic acid immunoreactivity in the gerbil hippocampus following transient cerebral ischemia. (9729272)
1998
35
Effect of hyperglycemia on reperfusion-associated recovery of intracellular pH and high energy phosphates after transient cerebral ischemia in gerbils. (8985956)
1996
36
Temporal profile of neurochemical recovery following injury by transient cerebral ischemia. (7671023)
1995
37
Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia. (7595583)
1995
38
Golgi electron microscopic study of the cerebral cortex after transient cerebral ischemia and reperfusion in the gerbil. (7700519)
1994
39
Intrahippocampal administration of the NO synthase inhibitor L-NAME prevents working memory deficits in rats exposed to transient cerebral ischemia. (7512427)
1994
40
Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia. (7510779)
1994
41
N-methyl-D-aspartate receptor-mediated, prolonged afterdischarges of CA1 pyramidal cells following transient cerebral ischemia in the rat hippocampus in vivo. (7529643)
1994
42
Dynorphin A-(1-13) potently prevents memory dysfunctions induced by transient cerebral ischemia in mice. (8097164)
1993
43
Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia. (1491778)
1992
44
Hippocampal unit activity after transient cerebral ischemia in rats. (2547253)
1989
45
The response of GABAergic and cholinergic neurons to transient cerebral ischemia. (7104739)
1982
46
Transient cerebral ischemia: review of surgical results. (7375644)
1980
47
Management of transient cerebral ischemia. (573393)
1979
48
Of platelets, their antagonists, and transient cerebral ischemia. (338935)
1978
49
Epidemiology of stroke: emphasis on transient cerebral ischemia attacks and hypertension. (4811314)
1974
50
Focal transient cerebral ischemia in the squirrel monkey. Effect on brain adenosine triphosphate and lactate levels with electrocorticographic and pathologic correlation. (4623629)
1972

Genetic Variations for Transient Cerebral Ischemia

Expression for genes affiliated with Transient Cerebral Ischemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

Sources:
30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 54Reactome, 52QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Transient Cerebral Ischemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
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Compounds related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1glutamate4510.7CAMK2G, DRD1, KMO
2gnrh4510.6CAMK2G, PLA2G2A
3melittin4510.6PLA2G2A, PVALB, RPS27A
4atpgammas4510.6HSPA4, ADORA1, CAMK2G
5methamphetamine45 50 1112.6PVALB, MAP2, DRD1, RPS27A
6bapta4510.6HSPA1A, CAMK2G, FOS, ADORA1
7rotenone4510.5ODC1, BAD, RPS27A, HSPA4
84-hydroxynonenal45 2411.5PLA2G2A, ODC1, RPS27A, HSPA4, FOS
96-hydroxydopamine4510.5RPS27A, FOS, CDK5, DRD1
10haloperidol45 29 2 50 1114.5CAMK2G, PVALB, DRD1, HSPA4, FOS
11herbimycin a45 6011.4ODC1, RPS27A, HSPA4, CAMK2G, FOS
12gaba4510.4ADORA1, CAMK2G, PVALB, MAP2, RPS27A, DRD1
13aspirin45 50 29 2413.4ODC1, PLA2G2A, RPS27A, ADORA1, HSPA4
14acetylcholine45 50 29 11 2414.4ADORA1, DRD1, PLA2G2A, CAMK2G, PVALB, HSPA4
15levodopa45 1111.4CDK5, RPS27A, CAMK2G, DRD1
16silver4510.4HSPA4, RPS27A, PVALB, MAP2
17hydrogen45 2411.4HSPA1A, CAMK2G, CDK5, KYNU, RPS27A
18genistein45 29 60 2 11 2415.4PLA2G2A, ADORA1, FOS, DRD1, ODC1, HSPA4
19cyclosporin a45 29 6012.4RPS27A, PLA2G2A, CAMK2G, HSPA1A, BAD, ODC1
20okadaic acid45 6011.3CDK5, CAMK2G, FOS, BAD, MAP2
21glycogen45 2411.3MAP2, CDK5, CAMK2G, HSPA1A, RPS27A, BAD
22cycloheximide4510.3ODC1, RPS27A, HSPA4, HSPA1A, CAMK2G, PLA2G2A
23pd 98,0594510.3HSPA4, BAD, CDK5, FOS, HSPA1A, CAMK2G
24cocaine45 1111.3CAMK2G, MAP2, ODC1, CDK5, HSPA4, FOS
25lactate4510.3MAP2, ODC1, HSPA4, HSPA1A, PLA2G2A, RPS27A
26cyclic amp45 2411.3BAD, MAP2, SYNGAP1, DRD1, FOS, CAMK2G
27actinomycin d4510.3PLA2G2A, BAD, CAMK2G, HSPA1A, HSPA4, RPS27A
28serine4510.3PLA2G2A, CDK5, MAP2, BAD, DRD1, FOS
29n acetylcysteine4510.3RPS27A, CDK5, BAD, FOS, HSPA4, PLA2G2A
30adenylate4510.2ODC1, HSPA4, CAMK2G, FOS, RPS27A, MAP2
31alpha tocopherol4510.2PLA2G2A, HSPA4, ODC1, HSPA1A
32dexamethasone45 50 29 1113.2RPS27A, BAD, HSPA1A, CAMK2G, FOS, ADORA1
33kainate45 2911.2HSPA4, ADORA1, FOS, ODC1, MAP2, DRD1
34alanine4510.2CAMK2G, CDK5, PLA2G2A, KYNU, ADORA1, HSPA4
35superoxide45 2411.2CAMK2G, CDK5, PLA2G2A, MAP2, HSPA4, HSPA1A
36estrogen4510.2ODC1, BAD, RPS27A, HSPA1A, PVALB, FOS
37atp45 2911.2ADORA1, CDK5, CAMK2G, PVALB, HSPA1A, HSPA4
38quinolinic acid45 2411.2KYNU, KMO, PVALB
39dopamine45 29 11 2413.2RPS27A, PLA2G2A, ADORA1, ODC1, CDK5, MAP2
40nmda45 2911.2SYNGAP1, MAP2, ADORA1, FOS, CAMK2G, HSPA4
41retinoic acid45 2411.2PLA2G2A, CDK5, MAP2, BAD, FOS, HSPA4
42morphine45 50 29 1113.1FOS, DRD1, CDK5, CAMK2G
43aspartate4510.1ODC1, ADORA1, RPS27A, HSPA1A, HSPA4, PVALB
44h2o24510.1PLA2G2A, HSPA1A, CAMK2G, CDK5, MAP2, FOS
45nitric oxide45 11 2412.1HSPA1A, HSPA4, ODC1, PVALB, DRD1, BAD
46paclitaxel45 50 1112.0ODC1, HSPA4, BAD, MAP2, CDK5
47threonine4510.0CDK5, CAMK2G, RPS27A, MAP2, FOS, BAD
48tyrosine4510.0RPS27A, ODC1, DRD1, KYNU, HSPA1A, PVALB
49calcium45 50 11 2412.9DRD1, ADORA1, PLA2G2A, MAP1A, MAP2, BAD
50methionine459.8ODC1, HSPA4, HSPA1A, MAP2, PVALB

GO Terms for genes affiliated with Transient Cerebral Ischemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.7KYNU, KMO, CDK5, MAP1A, BAD, FOS

Biological processes related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:01980510.6KMO, KYNU
2tryptophan catabolic process to kynurenineGO:01944110.6KYNU, KMO
3conditioned taste aversionGO:00166110.6DRD1, FOS
4positive regulation of potassium ion transportGO:04326810.6DRD1, ADORA1
5tryptophan catabolic processGO:00656910.5KMO, KYNU
6regulation of synaptic plasticityGO:04816710.5ADORA1, CDK5, SYNGAP1
7visual learningGO:00854210.5DRD1, SYNGAP1, CDK5
8synaptic transmission, dopaminergicGO:00196310.5CDK5, DRD1
9behavioral response to cocaineGO:04814810.4DRD1, CDK5
10receptor clusteringGO:04311310.4SYNGAP1, CDK5
11NAD biosynthetic processGO:00943510.4KYNU, KMO
12temperature homeostasisGO:00165910.4DRD1, ADORA1
13apoptotic signaling pathwayGO:09719010.1BAD, ADORA1, RPS27A
14central nervous system neuron developmentGO:02195410.0MAP2, CDK5

Products for genes affiliated with Transient Cerebral Ischemia

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Sources for Transient Cerebral Ischemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet