TIA
MCID: TRN015
MIFTS: 52

Transient Cerebral Ischemia (TIA) malady

Cardiovascular diseases category
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Summaries for Transient Cerebral Ischemia

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Sources:
34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and memory impairment. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are Tryptophan metabolism and tryptophan utilization II. The compounds 3-hydroxykynurenine and Hydroxykynurenine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord.

NINDS:44 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:65 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 44NINDS, 34MedlinePlus, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

transient cerebral ischemia 8 10 45 62
transient ischemic attack 8 44 45 34 62
transient cerebral ischaemia nos 8
tia - transient ischaemic attack 8
transient cerebral ischaemia 8
transient ischemic attacks 8
tia 8


External Ids:

Disease Ontology8 DOID:224
MeSH35 D002546
NCIt40 C50781

Related Diseases for Transient Cerebral Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia32.0CAMK2G, PLA2G2A, ADORA1, KMO
2memory impairment30.5DRD1, ADORA1
3brain ischemia30.5CAMK2G, ADORA1
4tauopathy30.5CAMK2G, RPS27A
5insulin resistance30.2RPS27A, PLA2G2A, ADORA1
6alzheimer's disease30.0ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
7cerebrovascular disease30.0CAMK2G, PLA2G2A, ADORA1, ODC1
8cerebritis11.4
9neuronitis11.1
10mini stroke10.5
11endotheliitis10.5
12cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.5
13carotid artery occlusion10.4
14artery disease10.4
15carotid artery disease10.4
16hyperglycemia10.4
17peripheral vascular disease10.3
18deficiency anemia10.3
19iron deficiency anemia10.3
20protein c deficiency10.3
21periodontitis10.3
22hypertension10.3
23meningioma10.3
24migraine10.3
25brain injury10.3
26hypoxia10.3
27thrombocythemia 110.3
28moyamoya disease10.3
29carotid stenosis10.3
30patent foramen ovale10.2
31antiphospholipid syndrome10.2
32homocystinuria10.2
33leukostasis10.2
34petroclival meningioma10.2
35ulcerative colitis10.2
36cerebral artery occlusion10.2
37arteriovenous malformation10.2
38prosopagnosia10.2
39silent myocardial infarction10.2
40systemic lupus erythematosus10.2
41sagittal sinus thrombosis10.2
42vertebrobasilar insufficiency10.2
43aphasia10.2
44cholesterol embolism10.2
45gingivitis10.2
46hemolytic anemia10.2
47leukemia10.2
48lupus erythematosus10.2
49lymphopenia10.2
50myocardial infarction10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Symptoms for Transient Cerebral Ischemia

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Drugs & Therapeutics for Transient Cerebral Ischemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

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Anatomical Context for Transient Cerebral Ischemia

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33MalaCards
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MalaCards organs/tissues related to Transient Cerebral Ischemia:

33
Brain, Eye, Spinal cord, Endothelial, Cortex, Olfactory bulb, Spleen, Testes, Thyroid

Animal Models for Transient Cerebral Ischemia or affiliated genes

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Publications for Transient Cerebral Ischemia

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52PubMed
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Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. (24321754)
2013
2
Comparison of inflammatory cytokines changes in the hippocampal CA1 region between the young and adult gerbil after transient cerebral ischemia. (22578357)
2012
3
Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. (22052512)
2012
4
EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. (22575539)
2012
5
Time-course alterations of Toll-like receptor 4 and NF-I_B p65, and their co-expression in the gerbil hippocampal CA1 region after transient cerebral ischemia. (21842272)
2011
6
Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. (21472764)
2011
7
Relation among neuronal death, cell proliferation and neuronal differentiation in the gerbil main olfactory bulb after transient cerebral ischemia. (20405201)
2010
8
2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats. (20840843)
2010
9
DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. (18854841)
2009
10
Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat. (19185320)
2009
11
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
12
Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. (17391653)
2007
13
Clinical observation on 30 cases of transient cerebral ischemia attack treated with acupuncture and medication. (17710801)
2007
14
Postprandial limb-shaking: an unusual presentation of transient cerebral ischemia. (16763755)
2006
15
Co-translational protein aggregation after transient cerebral ischemia. (16039801)
2005
16
Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils. (15338328)
2004
17
Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia. (12427474)
2003
18
Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. (14753432)
2003
19
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. (14580322)
2003
20
Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. (12812761)
2003
21
A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: effects on transient cerebral ischemia in cats. (12685856)
2002
22
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. (11821016)
2002
23
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. (11672836)
2001
24
Protective effects of SM-20302, an orally active GPIIb/IIIa antagonist, in an ADP/epinephrine-induced guinea pig model of transient cerebral ischemia. (11228335)
2001
25
NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. (11478920)
2001
26
Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. (11090993)
2000
27
Effects of felbamate on brain polyamine changes following transient cerebral ischemia in the Mongolian gerbil. (11083508)
2000
28
Immunocytochemical localization of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS) in rat neurohypophysis after transient cerebral ischemia. (10337059)
1999
29
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
30
Decreased expression and functionality of NMDA receptor complexes persist in the CA1, but not in the dentate gyrus after transient cerebral ischemia. (9663507)
1998
31
Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. (9591847)
1998
32
Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. (9634557)
1998
33
The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. (9838092)
1998
34
Expression of Ca2+-dependent (classical) PKC mRNA isoforms after transient cerebral ischemia in gerbil hippocampus. (9473687)
1998
35
Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. (9493961)
1997
36
Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. (9347348)
1997
37
The effect of hypothermia on protein synthesis and the expression of immediate early genes following transient cerebral ischemia. (8790800)
1996
38
A new model of transient cerebral ischemia in neonatal rats. (8594055)
1996
39
Disruption of the blood-cerebrospinal fluid barrier by transient cerebral ischemia. (8137165)
1994
40
Regional [14C]palmitate incorporation into the hippocampus after transient cerebral ischemia in awake gerbils. (2396510)
1990
41
Effects of transient cerebral ischemia on the hippocampal dentate theta (theta) profile in the acute rat: a study 4-5 months following recirculation. (2337781)
1990
42
Immunocytochemical investigation of L-glutamic acid decarboxylase in the rat hippocampal formation: the influence of transient cerebral ischemia. (2925901)
1989
43
Hippocampal unit activity after transient cerebral ischemia in rats. (2547253)
1989
44
Selective neuronal vulnerability following transient cerebral ischemia in the gerbil: distribution and time course. (2618582)
1989
45
Transient cerebral ischemia: diagnostic considerations. (6987710)
1980
46
Management of transient cerebral ischemia. (573393)
1979
47
Use of a computerized information system in the management of patients with transient cerebral ischemia. (571065)
1979
48
Plasma lipids and lipoproteins in patients with cerebral infarct or transient cerebral ischemia. (222104)
1979
49
Platelet aggregation and fibrinolytic activity in transient cerebral ischemia. (842281)
1977
50
Transient cerebral ischemia. Prevalence and prognosis in a biracial rural community. (4740273)
1973

Variations for Transient Cerebral Ischemia

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Expression for genes affiliated with Transient Cerebral Ischemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN
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Pathways related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7KYNU, KMO
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)38
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA38
tryptophan degradation38
glutaryl-CoA degradation38
serotonin degradation38
NAD de novo biosynthesis38
superpathway of melatonin degradation38
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde38
tryptophan utilization I38
melatonin degradation I38
9.7KYNU, KMO
3
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde38
NAD salvage38
NAD metabolism60
9.7KMO, KYNU
4
Show member pathways
thioredoxin pathway38
9.7KMO, KYNU
5
Show member pathways
9.3DRD1, CAMK2G
6
Show member pathways
creatine-phosphate biosynthesis38
glycine degradation (creatine biosynthesis)38
putrescine biosynthesis III38
spermidine biosynthesis I38
tryptophan degradation via kynurenine38
spermine biosynthesis38
urea cycle38
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I38
tyrosine degradation I38
L-carnitine biosynthesis38
methylthiopropionate biosynthesis38
2-oxoglutarate decarboxylation to succinyl-CoA38
S-methyl-5-thioadenosine degradation II38
9.2KMO, KYNU, ODC1
7
Show member pathways
9.0DRD1, PLA2G2A, ADORA1
8
Show member pathways
8.8DRD1, CAMK2G, ADORA1
9
Show member pathways
8.1ODC1, KYNU, KMO, PLA2G2A, RPS27A

Compounds for genes affiliated with Transient Cerebral Ischemia

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
13-hydroxykynurenine4510.1KMO, KYNU
2Hydroxykynurenine2410.1KYNU, KMO
3L-Kynurenine2410.1KYNU, KMO
43-hydroxyanthranilic acid45 2411.1KYNU, KMO
5kynurenic acid45 29 2412.1KYNU, KMO
6n6-cyclopentyladenosine45 6111.0ADORA1, DRD1
7kynurenine4510.0KMO, KYNU
8sulpiride45 29 1112.0DRD1, ODC1
9indoleamine459.9KYNU, KMO
10quinolinic acid45 2410.9KMO, KYNU
11l-tryptophan51 29 45 24 1113.8KMO, KYNU
12dicoumarol459.7RPS27A, ODC1
13melittin459.7RPS27A, PLA2G2A
14formaldehyde45 2410.4ADORA1, RPS27A, DRD1
15atpgammas45 2910.4CAMK2G, ADORA1
164-hydroxynonenal45 2410.3ODC1, PLA2G2A, RPS27A
17levodopa45 1110.2DRD1, CAMK2G, RPS27A
18carbachol45 29 1111.1DRD1, CAMK2G, ADORA1
19diisopropylfluorophosphate459.1CAMK2G, ODC1
20n acetylcysteine459.1ODC1, PLA2G2A, RPS27A
21herbimycin a45 6110.0ODC1, RPS27A, CAMK2G
22isoproterenol45 1110.0ODC1, ADORA1, CAMK2G
23genistein45 29 61 3 24 1113.9DRD1, PLA2G2A, ADORA1, ODC1
245-hydroxytryptamine458.9ADORA1, PLA2G2A, CAMK2G
25norepinephrine45 24 1110.8DRD1, CAMK2G, ADORA1
26aspirin45 51 29 2411.8RPS27A, PLA2G2A, ADORA1, ODC1
27kainate45 299.8ODC1, ADORA1, CAMK2G, DRD1
28cocaine45 119.8DRD1, CAMK2G, ADORA1, ODC1
29ibmx45 61 2910.8ODC1, ADORA1, CAMK2G, DRD1
30estrogen458.7ODC1, ADORA1, RPS27A, DRD1
31guanine45 24 1110.7ADORA1, RPS27A, CAMK2G, DRD1
32gaba458.7ADORA1, RPS27A, CAMK2G, DRD1
33gnrh458.7ODC1, PLA2G2A, CAMK2G, DRD1
34histamine45 29 2410.5ODC1, ADORA1, PLA2G2A, CAMK2G
35actinomycin d458.5ODC1, PLA2G2A, RPS27A, CAMK2G
36cyclosporin a45 29 6110.4CAMK2G, RPS27A, PLA2G2A, ODC1
37cycloheximide458.4ODC1, PLA2G2A, RPS27A, CAMK2G
38h2o2458.4CAMK2G, RPS27A, PLA2G2A, ODC1
39dexamethasone45 51 29 1111.3ADORA1, PLA2G2A, RPS27A, CAMK2G
40atp45 299.3ADORA1, RPS27A, CAMK2G, DRD1
41cysteine458.2ODC1, PLA2G2A, RPS27A, DRD1
42tyrosine458.2ODC1, KYNU, RPS27A, CAMK2G, DRD1
43retinoic acid45 249.1CAMK2G, RPS27A, PLA2G2A, ODC1
44acetylcholine45 51 29 24 1112.1ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
45alanine458.0KYNU, ADORA1, PLA2G2A, RPS27A, CAMK2G
46dopamine45 29 24 1110.6ODC1, ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
47adenylate457.6ODC1, ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
48serine457.6ODC1, ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
49nmda45 298.3DRD1, ODC1, KMO, ADORA1, PLA2G2A, RPS27A
50glutamate457.3ODC1, KMO, ADORA1, PLA2G2A, RPS27A, CAMK2G

GO Terms for genes affiliated with Transient Cerebral Ischemia

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16Gene Ontology
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Cellular components related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.1CAMK2G, RPS27A
2cytosolGO:0058297.6CAMK2G, RPS27A, KMO, KYNU, ODC1

Biological processes related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:0198059.9KMO, KYNU
2tryptophan catabolic process to kynurenineGO:0194419.9KMO, KYNU
3tryptophan catabolic processGO:0065699.8KYNU, KMO
4positive regulation of potassium ion transportGO:0432689.8DRD1, ADORA1
5NAD biosynthetic processGO:0094359.7KMO, KYNU
6temperature homeostasisGO:0016599.5DRD1, ADORA1
7lipid catabolic processGO:0160429.3PLA2G2A, ADORA1
8cellular nitrogen compound metabolic processGO:0346418.9ODC1, KYNU, KMO
9small molecule metabolic processGO:0442818.2ODC1, KYNU, KMO, PLA2G2A, RPS27A

Products for genes affiliated with Transient Cerebral Ischemia

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  • Antibodies
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Sources for Transient Cerebral Ischemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet