TIA
MCID: TRN015
MIFTS: 53

Transient Cerebral Ischemia (TIA) malady

Cardiovascular diseases category
Download this MalaCard

Summaries for Transient Cerebral Ischemia

About this section


Fully expand this MalaCard
MedlinePlus:33 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards based summary: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and memory impairment. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are Tryptophan metabolism and tryptophan utilization II. The compounds 3-hydroxykynurenine and Hydroxykynurenine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord.

NINDS:43 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:65 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

About this section

Transient Cerebral Ischemia, Aliases & Descriptions:

Name: Transient Cerebral Ischemia 8 10 44 62
Transient Ischemic Attack 8 43 44 33 62
Tia - Transient Ischaemic Attack 8 62
Transient Cerebral Ischaemia 8 62
 
Transient Cerebral Ischaemia Nos 8
Transient Ischaemic Attacks 62
Transient Ischemic Attacks 8
Tia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:224
MeSH34 D002546
NCIt39 C50781

Related Diseases for Transient Cerebral Ischemia

About this section

Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.6KMO, ADORA1, PLA2G2A, CAMK2G
2memory impairment30.9ADORA1, DRD1
3brain ischemia30.5ADORA1, CAMK2G
4tauopathy30.5CAMK2G, RPS27A
5insulin resistance29.9PLA2G2A, ADORA1, RPS27A
6cerebrovascular disease29.5ADORA1, PLA2G2A, CAMK2G, ODC1
7alzheimer's disease29.3PLA2G2A, ADORA1, DRD1, CAMK2G, RPS27A
8cerebritis11.5
9neuronitis11.1
10mini stroke10.5
11endotheliitis10.5
12cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.5
13carotid artery occlusion10.4
14artery disease10.4
15carotid artery disease10.4
16hyperglycemia10.4
17striatonigral degeneration10.4RPS27A
18peripheral vascular disease10.4
19deficiency anemia10.4
20hereditary hemorrhagic telangiectasia10.4
21iron deficiency anemia10.4
22protein c deficiency10.4
23periodontitis10.4
24brain injury10.3
25hypertension10.3
26meningioma10.3
27migraine10.3
28hypoxia10.3
29thrombocythemia 110.3
30moyamoya disease10.3
31carotid stenosis10.3
32patent foramen ovale10.2
33cerebral hemorrhage10.2
34hemolytic anemia10.2
35leukemia10.2
36myocardial infarction10.2
37systemic lupus erythematosus10.2
38ulcerative colitis10.2
39antiphospholipid syndrome10.2
40petroclival meningioma10.2
41poems syndrome10.2
42leukostasis10.2
43silent myocardial infarction10.2
44vertebrobasilar insufficiency10.2
45homocystinuria10.2
46peripartum cardiomyopathy10.2
47cerebral artery occlusion10.2
48prosopagnosia10.2
49pseudotumor cerebri10.2
50arteriovenous malformation10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Symptoms for Transient Cerebral Ischemia

About this section

Drugs & Therapeutics for Transient Cerebral Ischemia

About this section

Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

About this section

Anatomical Context for Transient Cerebral Ischemia

About this section

MalaCards organs/tissues related to Transient Cerebral Ischemia:

32
Brain, Eye, Spinal cord, Endothelial, Cortex, Olfactory bulb, Bone marrow, Bone, Spleen, Thyroid, Testes

Animal Models for Transient Cerebral Ischemia or affiliated genes

About this section

Publications for Transient Cerebral Ischemia

About this section

Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 394)
idTitleAuthorsYear
1
Accelerated and exacerbated effects of high dietary fat on neuronal damage induced by transient cerebral ischemia in the gerbil septum. (25309792)
2014
2
Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. (24321754)
2013
3
Comparison of inflammatory cytokines changes in the hippocampal CA1 region between the young and adult gerbil after transient cerebral ischemia. (22578357)
2012
4
Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. (22052512)
2012
5
EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. (22575539)
2012
6
Time-course alterations of Toll-like receptor 4 and NF-I_B p65, and their co-expression in the gerbil hippocampal CA1 region after transient cerebral ischemia. (21842272)
2011
7
Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. (21472764)
2011
8
Relation among neuronal death, cell proliferation and neuronal differentiation in the gerbil main olfactory bulb after transient cerebral ischemia. (20405201)
2010
9
2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats. (20840843)
2010
10
DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. (18854841)
2009
11
Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat. (19185320)
2009
12
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
13
Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. (17391653)
2007
14
Clinical observation on 30 cases of transient cerebral ischemia attack treated with acupuncture and medication. (17710801)
2007
15
Postprandial limb-shaking: an unusual presentation of transient cerebral ischemia. (16763755)
2006
16
Co-translational protein aggregation after transient cerebral ischemia. (16039801)
2005
17
Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils. (15338328)
2004
18
Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia. (12427474)
2003
19
Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. (14753432)
2003
20
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. (14580322)
2003
21
Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. (12812761)
2003
22
A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: effects on transient cerebral ischemia in cats. (12685856)
2002
23
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. (11821016)
2002
24
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. (11672836)
2001
25
Protective effects of SM-20302, an orally active GPIIb/IIIa antagonist, in an ADP/epinephrine-induced guinea pig model of transient cerebral ischemia. (11228335)
2001
26
NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. (11478920)
2001
27
Effects of felbamate on brain polyamine changes following transient cerebral ischemia in the Mongolian gerbil. (11083508)
2000
28
Immunocytochemical localization of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS) in rat neurohypophysis after transient cerebral ischemia. (10337059)
1999
29
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
30
Decreased expression and functionality of NMDA receptor complexes persist in the CA1, but not in the dentate gyrus after transient cerebral ischemia. (9663507)
1998
31
Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. (9591847)
1998
32
Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. (9634557)
1998
33
The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. (9838092)
1998
34
Expression of Ca2+-dependent (classical) PKC mRNA isoforms after transient cerebral ischemia in gerbil hippocampus. (9473687)
1998
35
Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. (9493961)
1997
36
Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. (9347348)
1997
37
The effect of hypothermia on protein synthesis and the expression of immediate early genes following transient cerebral ischemia. (8790800)
1996
38
A new model of transient cerebral ischemia in neonatal rats. (8594055)
1996
39
Disruption of the blood-cerebrospinal fluid barrier by transient cerebral ischemia. (8137165)
1994
40
Regional [14C]palmitate incorporation into the hippocampus after transient cerebral ischemia in awake gerbils. (2396510)
1990
41
Effects of transient cerebral ischemia on the hippocampal dentate theta (theta) profile in the acute rat: a study 4-5 months following recirculation. (2337781)
1990
42
Immunocytochemical investigation of L-glutamic acid decarboxylase in the rat hippocampal formation: the influence of transient cerebral ischemia. (2925901)
1989
43
Hippocampal unit activity after transient cerebral ischemia in rats. (2547253)
1989
44
Selective neuronal vulnerability following transient cerebral ischemia in the gerbil: distribution and time course. (2618582)
1989
45
Transient cerebral ischemia: diagnostic considerations. (6987710)
1980
46
Management of transient cerebral ischemia. (573393)
1979
47
Use of a computerized information system in the management of patients with transient cerebral ischemia. (571065)
1979
48
Plasma lipids and lipoproteins in patients with cerebral infarct or transient cerebral ischemia. (222104)
1979
49
Platelet aggregation and fibrinolytic activity in transient cerebral ischemia. (842281)
1977
50
Transient cerebral ischemia. Prevalence and prognosis in a biracial rural community. (4740273)
1973

Variations for Transient Cerebral Ischemia

About this section

Expression for genes affiliated with Transient Cerebral Ischemia

About this section
Expression patterns in normal tissues for genes affiliated with Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

About this section

Pathways related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7KYNU, KMO
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.7KYNU, KMO
3
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde37
NAD salvage37
NAD metabolism60
9.7KMO, KYNU
4
Show member pathways
thioredoxin pathway37
9.7KMO, KYNU
5
Show member pathways
9.3CAMK2G, DRD1
6
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
9.2KMO, KYNU, ODC1
7
Show member pathways
9.0DRD1, ADORA1, PLA2G2A
8
Show member pathways
8.8ADORA1, CAMK2G, DRD1
9
Show member pathways
8.1RPS27A, KMO, KYNU, PLA2G2A, ODC1

Compounds for genes affiliated with Transient Cerebral Ischemia

About this section

Compounds related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
13-hydroxykynurenine4410.1KMO, KYNU
2Hydroxykynurenine2410.1KMO, KYNU
3L-Kynurenine2410.1KMO, KYNU
4kynurenic acid44 28 2412.1KYNU, KMO
53-hydroxyanthranilic acid44 2411.1KMO, KYNU
6n6-cyclopentyladenosine44 6111.0ADORA1, DRD1
7kynurenine4410.0KYNU, KMO
8sulpiride44 28 1112.0DRD1, ODC1
9indoleamine449.9KYNU, KMO
10quinolinic acid44 2410.9KMO, KYNU
11l-tryptophan50 28 44 24 1113.8KMO, KYNU
12dicoumarol449.7RPS27A, ODC1
13melittin449.7RPS27A, PLA2G2A
14formaldehyde44 2410.4DRD1, RPS27A, ADORA1
15atpgammas44 2810.4CAMK2G, ADORA1
164-hydroxynonenal44 2410.3ODC1, RPS27A, PLA2G2A
17levodopa44 1110.2RPS27A, DRD1, CAMK2G
18carbachol44 28 1111.1DRD1, ADORA1, CAMK2G
19diisopropylfluorophosphate449.1CAMK2G, ODC1
20n acetylcysteine449.1ODC1, RPS27A, PLA2G2A
21herbimycin a44 6110.0CAMK2G, RPS27A, ODC1
22isoproterenol44 1110.0CAMK2G, ODC1, ADORA1
23genistein44 28 61 2 24 1113.9PLA2G2A, ADORA1, DRD1, ODC1
245-hydroxytryptamine448.9PLA2G2A, CAMK2G, ADORA1
25norepinephrine44 24 1110.8CAMK2G, ADORA1, DRD1
26aspirin44 50 28 2411.8ODC1, ADORA1, PLA2G2A, RPS27A
27kainate44 289.8CAMK2G, ODC1, ADORA1, DRD1
28cocaine44 119.8CAMK2G, ADORA1, ODC1, DRD1
29ibmx44 61 2810.8DRD1, CAMK2G, ADORA1, ODC1
30estrogen448.7DRD1, ODC1, ADORA1, RPS27A
31guanine44 24 1110.7CAMK2G, DRD1, RPS27A, ADORA1
32gaba448.7ADORA1, RPS27A, DRD1, CAMK2G
33gnrh448.7CAMK2G, PLA2G2A, ODC1, DRD1
34histamine44 28 2410.5ADORA1, ODC1, CAMK2G, PLA2G2A
35actinomycin d448.5PLA2G2A, RPS27A, CAMK2G, ODC1
36cyclosporin a44 28 6110.4PLA2G2A, ODC1, CAMK2G, RPS27A
37cycloheximide448.4RPS27A, CAMK2G, PLA2G2A, ODC1
38h2o2448.4PLA2G2A, ODC1, RPS27A, CAMK2G
39dexamethasone44 50 28 1111.3ADORA1, PLA2G2A, CAMK2G, RPS27A
40atp44 289.3RPS27A, CAMK2G, DRD1, ADORA1
41cysteine448.2DRD1, PLA2G2A, RPS27A, ODC1
42tyrosine448.2RPS27A, CAMK2G, DRD1, KYNU, ODC1
43retinoic acid44 249.1RPS27A, PLA2G2A, CAMK2G, ODC1
44acetylcholine44 50 28 24 1112.1ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
45alanine448.0KYNU, ADORA1, RPS27A, CAMK2G, PLA2G2A
46dopamine44 28 24 1110.6PLA2G2A, RPS27A, ADORA1, CAMK2G, ODC1, DRD1
47adenylate447.6RPS27A, CAMK2G, ADORA1, DRD1, ODC1, PLA2G2A
48serine447.6ADORA1, ODC1, PLA2G2A, RPS27A, CAMK2G, DRD1
49nmda44 288.3ODC1, KMO, ADORA1, DRD1, CAMK2G, RPS27A
50glutamate447.3DRD1, CAMK2G, RPS27A, PLA2G2A, ODC1, ADORA1

GO Terms for genes affiliated with Transient Cerebral Ischemia

About this section

Cellular components related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.1CAMK2G, RPS27A
2cytosolGO:0058297.6CAMK2G, RPS27A, KMO, KYNU, ODC1

Biological processes related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:0198059.9KMO, KYNU
2tryptophan catabolic process to kynurenineGO:0194419.9KMO, KYNU
3tryptophan catabolic processGO:0065699.8KYNU, KMO
4positive regulation of potassium ion transportGO:0432689.8DRD1, ADORA1
5NAD biosynthetic processGO:0094359.7KMO, KYNU
6temperature homeostasisGO:0016599.5DRD1, ADORA1
7lipid catabolic processGO:0160429.3PLA2G2A, ADORA1
8cellular nitrogen compound metabolic processGO:0346418.9ODC1, KYNU, KMO
9small molecule metabolic processGO:0442818.2ODC1, KYNU, KMO, PLA2G2A, RPS27A

Products for genes affiliated with Transient Cerebral Ischemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Transient Cerebral Ischemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet