TIA
MCID: TRN015
MIFTS: 55

Transient Cerebral Ischemia (TIA) malady

Summaries for Transient Cerebral Ischemia

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and tauopathy. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are ErbB signaling pathway and Development Glucocorticoid receptor signaling. The compounds glutamate and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord, and related mouse phenotype nervous system.

NINDS:43 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:63 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 43NINDS, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

transient cerebral ischemia 8 10 44 60
transient ischemic attack 8 43 44 33 60
transient cerebral ischaemia nos 8
tia - transient ischaemic attack 8
transient cerebral ischaemia 8
transient ischemic attacks 8
tia 8


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Disease Ontology8 DOID:224
MeSH34 D002546
NCIt39 C50781

Related Diseases for Transient Cerebral Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia32.1HSPA4, HSPA1A, PVALB, CAMK2G, BAD, MAP2
2tauopathy30.4RPS27A, CAMK2G, CDK5
3leukemia30.2HSPA4, CAMK2G, FOS, BAD, CDK5, PLA2G2A
4adenoma30.2PLA2G2A, HSPA1A, ODC1
5vascular disease30.2HSPA4, HSPA1A, FOS, MAP2, ADORA1
6cadasil30.2ODC1, HSPA4, PVALB, CAMK2G, MAP2, CDK5
7alzheimer's disease30.2RPS27A, HSPA1A, PVALB, CAMK2G, DRD1, BAD
8cerebritis11.4
9neuronitis11.0
10stroke, ischemic10.5
11mini stroke10.5
12cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.4
13carotid artery occlusion10.4
14carotid artery disease10.4
15hyperglycemia10.4
16peripheral vascular disease10.3
17deficiency anemia10.3
18iron deficiency anemia10.3
19protein c deficiency10.3
20periodontitis10.3
21brain edema10.3
22cerebral degeneration10.3
23cerebral meningioma10.3
24hypertension10.3
25meningioma10.3
26migraine10.3
27thrombocythemia 110.3
28moyamoya disease10.2
29carotid stenosis10.2
30patent foramen ovale10.2
31vertebrobasilar insufficiency10.2
32antiphospholipid syndrome10.2
33arteriovenous malformation10.2
34prosopagnosia10.2
35systemic lupus erythematosus10.2
36sagittal sinus thrombosis10.2
37petroclival meningioma10.2
38leukostasis10.2
39homocystinuria10.2
40ulcerative colitis10.2
41adult syndrome10.2
42silent myocardial infarction10.2
43acute leukemia10.2
44aphasia10.2
45brain disease10.2
46cholesterol embolism10.2
47gingivitis10.2
48hemolytic anemia10.2
49hemorrhagic disease10.2
50ischemic heart disease10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Clinical Features for Transient Cerebral Ischemia

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Drugs & Therapeutics for Transient Cerebral Ischemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Transient Cerebral Ischemia

Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Search CenterWatch for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

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Anatomical Context for Transient Cerebral Ischemia

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32MalaCards
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MalaCards organs/tissues related to Transient Cerebral Ischemia:

32
Brain, Eye, Spinal cord, Cortex, Endothelial, Testes, Olfactory bulb, Bone marrow, Thyroid, Bone, Spleen

Animal Models for Transient Cerebral Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Transient Cerebral Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.6ADORA1, HSPA1A, PVALB, FOS, DRD1, SYNGAP1

Publications for Transient Cerebral Ischemia

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50PubMed
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Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 442)
idTitleAuthorsYear
1
Neuroprotection by platelet-activating factor acetylhydrolase in a mouse model of transient cerebral ischemia. (24189491)
2014
2
Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. (24321754)
2013
3
Brain injury after transient global cerebral ischemia and subarachnoid hemorrhage. (24327930)
2013
4
Reduced beta-catenin expression in the hippocampal CA1 region following transient cerebral ischemia in the gerbil. (23504294)
2013
5
Effects of transient cerebral ischemia on the expression of DNA methyltransferase 1 in the gerbil hippocampal CA1 region. (22987057)
2013
6
Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice. (22345048)
2012
7
Early predictive biomarkers for lesion after transient cerebral ischemia. (21293024)
2011
8
Remifentanil alleviates transient cerebral ischemia-induced memory impairment through suppression of apoptotic neuronal cell death in gerbils. (21860753)
2011
9
In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice. (21571257)
2011
10
2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats. (20840843)
2010
11
Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats. (19584023)
2009
12
Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia. (19071026)
2009
13
Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia. (18665182)
2008
14
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
15
Immunohistochemical study on distribution of NF-kappaB and p53 in gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin. (17226097)
2007
16
Alterations of interneurons of the gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin. (15970948)
2005
17
Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. (15829914)
2005
18
Increased beta-secretase activity and expression in rats following transient cerebral ischemia. (15120577)
2004
19
Steady plasma concentration of unfractionated heparin reduces infarct volume and prevents inflammatory damage after transient focal cerebral ischemia in the rat. (15264226)
2004
20
Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances? (15548240)
2004
21
Expression of tumor necrosis factor alpha (TNFalpha) following transient cerebral ischemia. (14753413)
2003
22
Transient cerebral ischemia activates processing of xbp1 messenger RNA indicative of endoplasmic reticulum stress. (12679722)
2003
23
Concomitant up-regulation of astroglial high and low affinity nerve growth factor receptors in the CA1 hippocampal area following global transient cerebral ischemia in rat. (12849738)
2003
24
A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: effects on transient cerebral ischemia in cats. (12685856)
2002
25
Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. (12640176)
2002
26
Hyperglycemia enhances DNA fragmentation after transient cerebral ischemia. (11333367)
2001
27
Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. (11476596)
2001
28
Phosphorylation of extracellular signal-regulated kinase after transient cerebral ischemia in hyperglycemic rats. (11162246)
2001
29
Effects of felbamate on brain polyamine changes following transient cerebral ischemia in the Mongolian gerbil. (11083508)
2000
30
Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral ischemia. (10686402)
2000
31
Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia. (10974422)
2000
32
Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain. (10724115)
2000
33
Decreased hippocampal expression, but not functionality, of GABA(B) receptors after transient cerebral ischemia in rats. (9886058)
1999
34
Delayed recovery of cortical auditory evoked potentials and blood flow precede cortical neuronal death after transient cerebral ischemia in gerbils. (11186214)
1998
35
Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. (9262182)
1997
36
Changes in endoplasmic reticulum Ca(2-)-ATPase mRNA levels in transient cerebral ischemia of rat: a quantitative polymerase chain reaction study. (8905735)
1996
37
Disruption of the blood-cerebrospinal fluid barrier by transient cerebral ischemia. (8137165)
1994
38
Effects of naftidrofuryl oxalate, a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow following transient cerebral ischemia in gerbils. (7908849)
1994
39
Protein kinase C-like immunoreactivity in gerbil hippocampus after a transient cerebral ischemia. (7958073)
1994
40
Characteristics of transient cerebral ischemia-induced deficits on various learning and memory tasks in male Mongolian gerbils. (8121080)
1993
41
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat. (8478677)
1993
42
Hyperglycemia suppresses c-fos mRNA expression following transient cerebral ischemia in gerbils. (1727138)
1992
43
Regional [14C]palmitate incorporation into the hippocampus after transient cerebral ischemia in awake gerbils. (2396510)
1990
44
Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis. (2385215)
1990
45
Striatal glutamic acid and gamma-aminobutyric acid in transient cerebral ischemia in spontaneously hypertensive rats. (1976832)
1990
46
Decreases in excitatory synaptic transmission and increases in recurrent inhibition in the rat dentate gyrus after transient cerebral ischemia. (2598040)
1989
47
Comparison of amaurosis fugax and transient cerebral ischemia: a prospective clinical and arteriographic study. (4083852)
1985
48
Episodic dyskinesias and transient cerebral ischemia. (6890645)
1982
49
Plasma lipids and lipoproteins in patients with cerebral infarct or transient cerebral ischemia. (222104)
1979
50
Carotid endarterectomy in the treatment of transient cerebral ischemia. (1185140)
1975

Genetic Variations for Transient Cerebral Ischemia

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Expression for genes affiliated with Transient Cerebral Ischemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

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29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 53Reactome, 51QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Transient Cerebral Ischemia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7CAMK2G, DRD1, KMO
2gnrh4410.6PLA2G2A, CAMK2G
3melittin4410.6PLA2G2A, PVALB, RPS27A
4atpgammas4410.6HSPA4, CAMK2G, ADORA1
5methamphetamine44 49 1112.6RPS27A, PVALB, DRD1, MAP2
6bapta4410.6HSPA1A, CAMK2G, FOS, ADORA1
7rotenone4410.5BAD, HSPA4, RPS27A, ODC1
84-hydroxynonenal44 2411.5ODC1, RPS27A, HSPA4, FOS, PLA2G2A
96-hydroxydopamine4410.5RPS27A, FOS, DRD1, CDK5
10haloperidol44 28 2 49 1114.5HSPA4, PVALB, CAMK2G, FOS, DRD1
11herbimycin a44 5911.4ODC1, RPS27A, HSPA4, CAMK2G, FOS
12gaba4410.4RPS27A, PVALB, CAMK2G, DRD1, MAP2, ADORA1
13aspirin44 49 28 2413.4ODC1, RPS27A, HSPA4, PLA2G2A, ADORA1
14acetylcholine44 49 28 11 2414.4RPS27A, HSPA4, PVALB, CAMK2G, DRD1, PLA2G2A
15levodopa44 1111.4CDK5, DRD1, CAMK2G, RPS27A
16silver4410.4RPS27A, HSPA4, PVALB, MAP2
17hydrogen44 2411.4RPS27A, HSPA1A, CAMK2G, CDK5, KYNU
18genistein44 28 59 2 11 2415.4ODC1, HSPA4, FOS, DRD1, PLA2G2A, ADORA1
19cyclosporin a44 28 5912.4ODC1, RPS27A, HSPA1A, CAMK2G, BAD, PLA2G2A
20okadaic acid44 5911.3CDK5, MAP2, BAD, FOS, CAMK2G
21glycogen44 2411.3RPS27A, HSPA1A, CAMK2G, BAD, MAP2, CDK5
22cycloheximide4410.3ODC1, RPS27A, HSPA4, HSPA1A, CAMK2G, FOS
23pd 98,0594410.3HSPA4, HSPA1A, CAMK2G, FOS, BAD, CDK5
24cocaine44 1111.3ODC1, HSPA4, CAMK2G, FOS, DRD1, MAP2
25lactate4410.3ODC1, RPS27A, HSPA4, HSPA1A, MAP2, PLA2G2A
26cyclic amp44 2411.3HSPA1A, CAMK2G, FOS, DRD1, SYNGAP1, BAD
27actinomycin d4410.3ODC1, RPS27A, HSPA4, HSPA1A, CAMK2G, FOS
28serine4410.3PVALB, CAMK2G, FOS, DRD1, BAD, MAP2
29n acetylcysteine4410.3ODC1, RPS27A, HSPA4, HSPA1A, FOS, BAD
30adenylate4410.2ODC1, RPS27A, HSPA4, CAMK2G, FOS, DRD1
31alpha tocopherol4410.2ODC1, HSPA4, HSPA1A, PLA2G2A
32dexamethasone44 49 28 1113.2RPS27A, HSPA4, HSPA1A, CAMK2G, FOS, BAD
33kainate44 2811.2MAP2, DRD1, FOS, CAMK2G, PVALB, HSPA1A
34alanine4410.2RPS27A, HSPA4, CAMK2G, BAD, CDK5, PLA2G2A
35superoxide44 2411.2HSPA4, HSPA1A, CAMK2G, MAP2, CDK5, PLA2G2A
36estrogen4410.2ODC1, RPS27A, HSPA1A, PVALB, FOS, DRD1
37atp44 2811.2RPS27A, HSPA4, HSPA1A, PVALB, CAMK2G, DRD1
38quinolinic acid44 2411.2KYNU, KMO, PVALB
39dopamine44 28 11 2413.2ODC1, RPS27A, PVALB, CAMK2G, FOS, DRD1
40nmda44 2811.2ADORA1, ODC1, KMO, MAP2, SYNGAP1, FOS
41retinoic acid44 2411.2ODC1, RPS27A, HSPA4, CAMK2G, FOS, BAD
42morphine44 49 28 1113.1CAMK2G, FOS, DRD1, CDK5
43aspartate4410.1ODC1, RPS27A, HSPA4, HSPA1A, PVALB, ADORA1
44h2o24410.1ODC1, RPS27A, HSPA4, HSPA1A, CAMK2G, FOS
45nitric oxide44 11 2412.1ODC1, HSPA4, HSPA1A, PVALB, DRD1, BAD
46paclitaxel44 49 1112.0CDK5, MAP2, BAD, HSPA4, ODC1
47threonine4410.0RPS27A, CAMK2G, FOS, BAD, MAP2, CDK5
48tyrosine4410.0ODC1, RPS27A, HSPA1A, PVALB, CAMK2G, FOS
49calcium44 49 11 2412.9HSPA1A, PVALB, CAMK2G, FOS, DRD1, BAD
50methionine449.8ODC1, HSPA4, HSPA1A, PVALB, MAP2

GO Terms for genes affiliated with Transient Cerebral Ischemia

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16Gene Ontology
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Cellular components related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.7KYNU, KMO, CDK5, MAP1A, BAD, FOS

Biological processes related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:01980510.6KYNU, KMO
2tryptophan catabolic process to kynurenineGO:01944110.6KYNU, KMO
3conditioned taste aversionGO:00166110.6FOS, DRD1
4positive regulation of potassium ion transportGO:04326810.6ADORA1, DRD1
5regulation of synaptic plasticityGO:04816710.5ADORA1, CDK5, SYNGAP1
6visual learningGO:00854210.5CDK5, SYNGAP1, DRD1
7tryptophan catabolic processGO:00656910.5KMO, KYNU
8behavioral response to cocaineGO:04814810.5DRD1, CDK5
9synaptic transmission, dopaminergicGO:00196310.4DRD1, CDK5
10NAD biosynthetic processGO:00943510.4KYNU, KMO
11central nervous system neuron developmentGO:02195410.3CDK5, MAP2
12receptor clusteringGO:04311310.3CDK5, SYNGAP1
13apoptotic signaling pathwayGO:09719010.1RPS27A, BAD, ADORA1
14temperature homeostasisGO:00165910.1ADORA1, DRD1

Products for genes affiliated with Transient Cerebral Ischemia

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Sources for Transient Cerebral Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet