TIA
MCID: TRN015
MIFTS: 55

Transient Cerebral Ischemia (TIA) malady

Summaries for Transient Cerebral Ischemia

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and tauopathy. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are ErbB signaling pathway and Development Glucocorticoid receptor signaling. The compounds glutamate and gnrh have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord, and related mouse phenotype nervous system.

NINDS:43 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:63 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

transient cerebral ischemia 8 10 44 60
transient ischemic attack 8 43 44 33 60
transient cerebral ischaemia nos 8
tia - transient ischaemic attack 8
transient cerebral ischaemia 8
transient ischemic attacks 8
tia 8


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Disease Ontology8 DOID:224
MeSH34 D002546
NCIt39 C50781

Related Diseases for Transient Cerebral Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia32.1HSPA4, HSPA1A, PVALB, CAMK2G, BAD, MAP2
2tauopathy30.4RPS27A, CAMK2G, CDK5
3leukemia30.2HSPA4, CAMK2G, FOS, BAD, CDK5, PLA2G2A
4adenoma30.2PLA2G2A, HSPA1A, ODC1
5vascular disease30.2HSPA4, HSPA1A, FOS, MAP2, ADORA1
6cadasil30.2ODC1, HSPA4, PVALB, CAMK2G, MAP2, CDK5
7alzheimer's disease30.2RPS27A, HSPA1A, PVALB, CAMK2G, DRD1, BAD
8cerebritis11.4
9neuronitis11.0
10stroke, ischemic10.5
11mini stroke10.5
12cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants10.4
13carotid artery occlusion10.4
14carotid artery disease10.4
15hyperglycemia10.4
16peripheral vascular disease10.3
17deficiency anemia10.3
18iron deficiency anemia10.3
19protein c deficiency10.3
20periodontitis10.3
21brain edema10.3
22cerebral degeneration10.3
23cerebral meningioma10.3
24hypertension10.3
25meningioma10.3
26migraine10.3
27thrombocythemia 110.3
28moyamoya disease10.2
29carotid stenosis10.2
30patent foramen ovale10.2
31vertebrobasilar insufficiency10.2
32antiphospholipid syndrome10.2
33arteriovenous malformation10.2
34prosopagnosia10.2
35systemic lupus erythematosus10.2
36sagittal sinus thrombosis10.2
37petroclival meningioma10.2
38leukostasis10.2
39homocystinuria10.2
40ulcerative colitis10.2
41adult syndrome10.2
42silent myocardial infarction10.2
43acute leukemia10.2
44aphasia10.2
45brain disease10.2
46cholesterol embolism10.2
47gingivitis10.2
48hemolytic anemia10.2
49hemorrhagic disease10.2
50ischemic heart disease10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Clinical Features for Transient Cerebral Ischemia

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Drugs & Therapeutics for Transient Cerebral Ischemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Transient Cerebral Ischemia

Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Search CenterWatch for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

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Anatomical Context for Transient Cerebral Ischemia

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32MalaCards
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MalaCards organs/tissues related to Transient Cerebral Ischemia:

32
Brain, Eye, Spinal cord, Cortex, Endothelial, Testes, Olfactory bulb, Thyroid, Spleen, Bone, Bone marrow

Animal Models for Transient Cerebral Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Transient Cerebral Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.6ADORA1, HSPA1A, PVALB, FOS, DRD1, SYNGAP1

Publications for Transient Cerebral Ischemia

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50PubMed
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Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 442)
idTitleAuthorsYear
1
Effect of repeated allogeneic bone marrow mononuclear cell transplantation on brain injury following transient focal cerebral ischemia in rats. (24368140)
2014
2
The Roles of p38 MAPK/MSK1 Signaling Pathway in the Neuroprotection of Hypoxic Postconditioning Against Transient Global Cerebral Ischemia in Adult Rats. (24352802)
2013
3
Neuronal damage and gliosis in the somatosensory cortex induced by various durations of transient cerebral ischemia in gerbils. (23528266)
2013
4
Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation. (23642800)
2013
5
Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems. (23044614)
2012
6
Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia. (22552890)
2012
7
Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia. (22933585)
2012
8
Increases of antioxidants are related to more delayed neuronal death in the hippocampal CA1 region of the young gerbil induced by transient cerebral ischemia. (22032878)
2011
9
Neuroprotective effects of Alpinia katsumadai against neuronal damage in the gerbil hippocampus induced by transient cerebral ischemia. (21819294)
2011
10
In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia. (20936709)
2010
11
Effect of combination therapy with sodium ozagrel and panax ginseng on transient cerebral ischemia model in rats. (21274269)
2010
12
Inhibition of Src activity decreases tyrosine phosphorylation of occludin in brain capillaries and attenuates increase in permeability of the blood-brain barrier after transient focal cerebral ischemia. (19319148)
2009
13
Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats. (19209181)
2009
14
The effects of transient cerebral ischemia on vasopressin-induced vasoconstriction in rabbit cerebral vessels. (18292439)
2008
15
Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. (18323734)
2008
16
Preconditioning ischemia attenuates increased neurexin-neuroligin1-PSD-95 interaction after transient cerebral ischemia in rat hippocampus. (17904739)
2007
17
Activin is a neuronal survival factor that is rapidly increased after transient cerebral ischemia and hypoxia in mice. (17133227)
2007
18
Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. (17600230)
2007
19
1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia. (16420413)
2006
20
Ischemic preconditioning prevents protein aggregation after transient cerebral ischemia. (15939539)
2005
21
Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus. (15710244)
2005
22
Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. (14982935)
2004
23
Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets. (15201509)
2004
24
Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia. (12427474)
2003
25
Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. (14753432)
2003
26
Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. (14526224)
2003
27
Alpha-melanocyte stimulating hormone suppresses intracerebral tumor necrosis factor-alpha and interleukin-1beta gene expression following transient cerebral ischemia in mice. (12453626)
2002
28
Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. (11090993)
2000
29
Differential expression of HSC73 and HSP72 mRNA and proteins between young and adult gerbils after transient cerebral ischemia: relation to neuronal vulnerability. (10908039)
2000
30
Immunoelectron microscopic study of c-Fos, c-Jun and heat shock protein after transient cerebral ischemia in gerbils. (9930891)
1999
31
Assembly of proteins to postsynaptic densities after transient cerebral ischemia. (9425004)
1998
32
Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis. (9488173)
1998
33
A new model of transient cerebral ischemia in neonatal rats. (8594055)
1996
34
Regional alterations of protein kinase C activity following transient cerebral ischemia: effects of intraischemic brain temperature modulation. (8051550)
1994
35
Long-term observations in gerbil brain following transient cerebral ischemia: autoradiographic and histological study. (8272028)
1993
36
Neuronal uptake of plasma proteins after transient cerebral ischemia/hypoxia. Immunohistochemical studies on experimental animals and human brains. (8267954)
1993
37
Effect of vinconate against alterations in [3H]naloxone, [3H]MK-801 and [3H]muscimol bindings after transient cerebral ischemia in gerbils. (8110027)
1993
38
U-50,488H, a kappa-opioid receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice. (8397052)
1993
39
Adenosine release and changes in pial arteriolar diameter during transient cerebral ischemia and reperfusion. (1939392)
1991
40
Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia. (2538582)
1989
41
NMR imaging in transient cerebral ischemia. (4016944)
1985
42
Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia. (6695429)
1984
43
Resistance of hippocampal CA-1 interneurons to 20 min of transient cerebral ischemia in the rat. (6637398)
1983
44
Meningioma presenting as recurrent transient cerebral ischemia and intracranial hemorrhage. (7200265)
1982
45
Significance of ulcerated plaque in transient cerebral ischemia. (7212183)
1981
46
Transient cerebral ischemia: diagnostic considerations. (6987710)
1980
47
Regional brain glucose metabolism during recovery from transient cerebral ischemia. (268757)
1977
48
Causes of transient cerebral ischemia. (576960)
1977
49
Transient cerebral ischemia. (1146393)
1975
50
Ulcerated atheroma of the carotid artery. A cause of transient cerebral ischemia. (5675281)
1968

Genetic Variations for Transient Cerebral Ischemia

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Expression for genes affiliated with Transient Cerebral Ischemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Cerebral Ischemia

Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

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29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 53Reactome, 51QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Transient Cerebral Ischemia

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1glutamate4410.7CAMK2G, DRD1, KMO
2gnrh4410.6CAMK2G, PLA2G2A
3melittin4410.6RPS27A, PLA2G2A, PVALB
4atpgammas4410.6HSPA4, ADORA1, CAMK2G
5methamphetamine44 49 1112.6MAP2, PVALB, DRD1, RPS27A
6bapta4410.6ADORA1, CAMK2G, HSPA1A, FOS
7rotenone4410.5BAD, RPS27A, ODC1, HSPA4
84-hydroxynonenal44 2411.5ODC1, HSPA4, PLA2G2A, FOS, RPS27A
96-hydroxydopamine4410.5CDK5, DRD1, RPS27A, FOS
10haloperidol44 28 2 49 1114.5FOS, DRD1, CAMK2G, PVALB, HSPA4
11herbimycin a44 5911.4ODC1, FOS, CAMK2G, HSPA4, RPS27A
12gaba4410.4MAP2, ADORA1, DRD1, CAMK2G, RPS27A, PVALB
13aspirin44 49 28 2413.4ADORA1, PLA2G2A, HSPA4, RPS27A, ODC1
14acetylcholine44 49 28 11 2414.4CAMK2G, HSPA4, RPS27A, PVALB, DRD1, PLA2G2A
15levodopa44 1111.4DRD1, RPS27A, CDK5, CAMK2G
16silver4410.4PVALB, RPS27A, HSPA4, MAP2
17hydrogen44 2411.4CDK5, KYNU, RPS27A, HSPA1A, CAMK2G
18genistein44 28 59 2 11 2415.4ODC1, HSPA4, DRD1, PLA2G2A, ADORA1, FOS
19cyclosporin a44 28 5912.4BAD, RPS27A, HSPA1A, PLA2G2A, ODC1, CAMK2G
20okadaic acid44 5911.3CDK5, CAMK2G, FOS, BAD, MAP2
21glycogen44 2411.3BAD, RPS27A, CDK5, MAP2, HSPA1A, CAMK2G
22cycloheximide4410.3ODC1, RPS27A, HSPA4, HSPA1A, CAMK2G, FOS
23pd 98,0594410.3CDK5, CAMK2G, BAD, HSPA4, HSPA1A, FOS
24cocaine44 1111.3ADORA1, ODC1, CDK5, FOS, CAMK2G, DRD1
25lactate4410.3ODC1, RPS27A, HSPA4, MAP2, HSPA1A, PLA2G2A
26cyclic amp44 2411.3CAMK2G, ADORA1, HSPA1A, MAP2, BAD, SYNGAP1
27actinomycin d4410.3HSPA1A, HSPA4, CAMK2G, RPS27A, ODC1, FOS
28serine4410.3PLA2G2A, CDK5, MAP2, BAD, DRD1, FOS
29n acetylcysteine4410.3ODC1, HSPA4, HSPA1A, RPS27A, PLA2G2A, CDK5
30adenylate4410.2DRD1, MAP2, FOS, CAMK2G, HSPA4, RPS27A
31alpha tocopherol4410.2PLA2G2A, HSPA1A, HSPA4, ODC1
32dexamethasone44 49 28 1113.2ADORA1, HSPA4, PLA2G2A, BAD, RPS27A, FOS
33kainate44 2811.2MAP2, FOS, ODC1, HSPA4, HSPA1A, PVALB
34alanine4410.2ADORA1, KYNU, PLA2G2A, CDK5, BAD, RPS27A
35superoxide44 2411.2HSPA4, HSPA1A, CAMK2G, PLA2G2A, MAP2, CDK5
36estrogen4410.2ADORA1, PVALB, HSPA1A, RPS27A, ODC1, BAD
37atp44 2811.2RPS27A, PVALB, CDK5, HSPA4, CAMK2G, DRD1
38quinolinic acid44 2411.2PVALB, KMO, KYNU
39dopamine44 28 11 2413.2MAP2, PLA2G2A, CAMK2G, ODC1, RPS27A, PVALB
40nmda44 2811.2MAP2, FOS, ODC1, RPS27A, HSPA4, PVALB
41retinoic acid44 2411.2PLA2G2A, MAP2, FOS, CAMK2G, HSPA4, RPS27A
42gf 109203x44 5911.2PLA2G2A, FOS, CAMK2G, HSPA4
43morphine44 49 28 1113.1CAMK2G, FOS, DRD1, CDK5
44aspartate4410.1HSPA1A, PVALB, HSPA4, RPS27A, ADORA1, ODC1
45h2o24410.1CAMK2G, FOS, BAD, MAP2, CDK5, HSPA1A
46nitric oxide44 11 2412.1DRD1, PVALB, MAP2, HSPA1A, BAD, HSPA4
47threonine4410.0RPS27A, FOS, MAP2, CDK5, KYNU, CAMK2G
48tyrosine4410.0RPS27A, HSPA1A, CAMK2G, FOS, DRD1, ODC1
49calcium44 49 11 2412.9PLA2G2A, CDK5, MAP1A, MAP2, PVALB, CAMK2G
50methionine449.8HSPA4, HSPA1A, ODC1, MAP2, PVALB

GO Terms for genes affiliated with Transient Cerebral Ischemia

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16Gene Ontology
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Cellular components related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.7KYNU, KMO, CDK5, MAP1A, BAD, FOS

Biological processes related to Transient Cerebral Ischemia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:01980510.6KYNU, KMO
2tryptophan catabolic process to kynurenineGO:01944110.6KYNU, KMO
3conditioned taste aversionGO:00166110.6FOS, DRD1
4positive regulation of potassium ion transportGO:04326810.6ADORA1, DRD1
5regulation of synaptic plasticityGO:04816710.5ADORA1, CDK5, SYNGAP1
6visual learningGO:00854210.5CDK5, SYNGAP1, DRD1
7tryptophan catabolic processGO:00656910.5KMO, KYNU
8behavioral response to cocaineGO:04814810.5DRD1, CDK5
9synaptic transmission, dopaminergicGO:00196310.4DRD1, CDK5
10NAD biosynthetic processGO:00943510.4KYNU, KMO
11central nervous system neuron developmentGO:02195410.3CDK5, MAP2
12receptor clusteringGO:04311310.3CDK5, SYNGAP1
13apoptotic signaling pathwayGO:09719010.1RPS27A, BAD, ADORA1
14temperature homeostasisGO:00165910.1ADORA1, DRD1

Products for genes affiliated with Transient Cerebral Ischemia

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Sources for Transient Cerebral Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet