Transient Cerebral Ischemia malady

MedlinePlus: A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke²³

MalaCards: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to tauopathy and myositis. An important gene associated with Transient Cerebral Ischemia is KMO (kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)), and among its related pathways are Colorectal cancer and Tryptophan metabolism. The compounds egcg and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are immune system and hematopoietic system.

NINDS: A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.³¹

Wikipedia: A transient ischemic attack is a transient episode of neurologic dysfunction caused by ischemia (loss of...⁴⁴ more...

Aliases & Descriptions:

transient cerebral ischemia 6 8 32 43 transient ischemic attack 6 31 32 23 43 transient cerebral ischemia (disorder) 6 transient ischemic attacks (disorder) 6

tia - transient ischaemic attack 6 transient cerebral ischaemia nos 6 transient cerebral ischaemia 6 tia 6

Diseases related to transient cerebral ischemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 357)

id	Related Disease	Score	Top Affiliating Genes
1	tauopathy	32.1	CDK5, MAPT, CAMK2G, RPS27A
2	myositis	28.3	BCL2, JUN, CDK5, FOS, MAPT, CASP1
3	t-cell leukemia	27.8	BCL2, BAD, XIAP, JUN, FOS, CASP3
4	homocysteine	26.6	JUN, FOS, GSR, MAPT, IDO1, HSPA5
5	b-cell lymphomas	26.4	BCL2, BAD, XIAP, JUN, IDO1, HSPA5
6	alcoholism	26.3	GSR, GRIN2A, MAPT, DRD1, CP, GAD1
7	immunodeficiency	26.0	MAPT, IDO1, HSPA5, HSPA4, TGFB2, GAD1
8	hyperglycemia	25.7	BAD, XIAP, JUN, FOS, GSR, HSPA5
9	alcohol dependence	25.6	GRIN2A, MAP2, TUBA1B, DRD1, SOD1, CP
10	non-hodgkin lymphoma	25.5	BCL2, BAD, XIAP, GSR, CASP3, CASP1
11	duodenitis	25.5	BCL2, GSR, HSPA1A, HSPA4, ODC1, SOD1
12	motor neuron disease	25.2	CDK5, MAPT, HSPA4, RPS27A, PVALB, SOD1
13	adenoiditis	24.7	BCL2, HSPA4, CASP3, DYT10, PTK2B, CTSD
14	nasopharyngitis	24.7	BCL2, BAD, JUN, FOS, ALOX5, HSPA5
15	cadasil	24.3	CDK5, GSR, MAPT, MAP2, ALOX5, HSPA4
16	hodgkin's lymphoma	24.1	BCL2, BAD, XIAP, JUN, GSR, HSPA4
17	herpes simplex	23.8	BCL2, JUN, CDK5, IDO1, HSPA4, CASP3
18	ischemia	23.7	KIAA1147, BCL2, BAD, XIAP, JUN, CDK5
19	cerebritis	23.7	KIAA1147, BCL2, BAD, XIAP, JUN, CDK5
20	cystic fibrosis	23.5	JUN, GSR, ALOX5, HSPA5, HSPA4, CASP3
21	inflammatory bowel disease	23.2	BCL2, JUN, FOS, IDO1, ALOX5, HSPA4
22	neuropathy	22.8	JUN, GSR, MAPT, HSPA4, TUBA1B, DYT10
23	sarcoma	22.7	BCL2, BAD, XIAP, JUN, FOS, GSR
24	lymphocytic leukemia	22.3	BCL2, BAD, XIAP, FOS, GSR, IDO1
25	systemic lupus erythematosus	22.1	BCL2, JUN, FOS, GRIN2A, MAP2, IDO1
26	lupus erythematosus	22.0	BCL2, JUN, FOS, GRIN2A, MAP2, IDO1
27	esophagitis	21.8	BCL2, BAD, XIAP, JUN, CDK5, FOS
28	rheumatoid arthritis	21.7	BCL2, XIAP, ATP6V0D1, JUN, FOS, GSR
29	fibrosis	21.3	BCL2, JUN, FOS, GSR, IDO1, ALOX5
30	neuronitis	21.2	KIAA1147, BCL2, BAD, XIAP, ATP6V0D1, JUN
31	cervicitis	21.1	BCL2, XIAP, JUN, CDK5, FOS, GSR
32	arthritis	20.6	BCL2, XIAP, ATP6V0D1, JUN, FOS, GSR
33	amyotrophic lateral sclerosis	20.2	BCL2, BAD, JUN, CDK5, FOS, GSR
34	hepatitis	20.1	BCL2, BAD, XIAP, JUN, ITPR1, FOS
35	leukemia	20.0	BCL2, BAD, XIAP, JUN, CDK5, FOS
36	ovarian cancer	19.9	BCL2, BAD, XIAP, JUN, FOS, GSR
37	lateral sclerosis	19.9	BCL2, BAD, JUN, CDK5, FOS, GSR
38	alzheimer's disease	19.1	BCL2, BAD, XIAP, JUN, CDK5, ITPR1
39	melanoma	19.0	BCL2, BAD, XIAP, JUN, FOS, GSR
40	thyroiditis	19.0	BCL2, BAD, XIAP, JUN, CDK5, ITPR1
41	carcinoma	17.8	BCL2, BAD, XIAP, JUN, CDK5, ITPR1
42	hypoxia	17.5	BCL2, BAD, XIAP, JUN, CDK5, ITPR1
43	prostatitis	16.8	BCL2, BAD, XIAP, JUN, CDK5, ITPR1
44	striatonigral degeneration	13.7	MAP2, DRD1, RPS27A
45	basilar artery occlusion	13.5	HSPA1A, CAMK2G, DYT10
46	cerebral artery occlusion	13.4	FOS, MAPT, MAP2, ODC1
47	temporal lobe epilepsy	13.4	CAMK2G, PVALB, SLC1A1, ADORA1, GAD1
48	progressive supranuclear palsy	13.4	CDK5, MAPT, RPS27A, PVALB
49	memory impairment	13.4	CDK5, MAPT, DRD1, ADORA1
50	dentatorubral-pallidoluysian atrophy	13.3	CASP3, RPS27A, PVALB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to transient cerebral ischemia:

²²

MGI Mouse Phenotypes related to transient cerebral ischemia:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	9.0	SOD2, CTSD, DRD1, ERCC6, CAMK2G, CASP1
2	hematopoietic system phenotype	MP:0005397	8.9	SOD2, CXCR2, ERCC6, IDO1, XIAP, BAD
3	reproductive system phenotype	MP:0005389	8.8	SOD2, CXCR2, CAMK2G, CASP1, CASP3, HSPA5
4	tumorigenesis	MP:0002006	8.2	SOD2, CXCR2, PLA2G2A, ERCC6, CASP1, HSPA5
5	muscle phenotype	MP:0005369	7.3	SOD1, PVALB, TGFB2, PTK2B, DRD1, ERCC6
6	mortality/aging	MP:0010768	7.3	ERCC6, DRD1, ODC1, CTSD, TGFB2, SYNGAP1
7	nervous system phenotype	MP:0003631	7.2	DRD1, CTSD, TGFB2, PVALB, CXCR2, SLC1A1
8	integument phenotype	MP:0010771	6.9	HSPA5, ERCC6, DRD1, SOD2, ADORA1, MAPT
9	vision/eye phenotype	MP:0005391	6.7	TGFB2, CXCR2, SOD1, SOD2, SLC1A1, CP
10	growth/size phenotype	MP:0005378	6.6	CASP3, ERCC6, DRD1, TGFB2, SYNGAP1, CXCR2
11	cardiovascular system phenotype	MP:0005385	6.2	PTK2B, TGFB2, CXCR2, SOD1, SOD2, CP
12	behavior/neurological phenotype	MP:0005386	5.8	CTSD, PVALB, SYNGAP1, SOD1, SOD2, SLC1A1
13	homeostasis/metabolism phenotype	MP:0005376	5.1	DRD1, PTK2B, CTSD, TGFB2, CXCR2, SOD1
14	cellular phenotype	MP:0005384	4.2	BCL2, DRD1, PTK2B, ODC1, CTSD, TGFB2

Articles related to transient cerebral ischemia:

(show all 30)

id	Title	Authors	Year	Affiliating Genes
1	EAAC1 gene deletion alters zinc homeostasis and exace rbates neuronal injury after transient cerebral ischemia. (21084597)	Won S.J.... Suh S.W.	2010	SLC1A1
2	Two region-dependent pathways of eosinophilic neuronal death after transient cerebral ischemia. (18627483)	Sun L.... Mizusawa H.	2009	CTSD, HSPA5
3	Transient Cerebral Ischemia Leads to TGF-beta2 Expression in Golgi Apparatus Organelles. (18691075)	Hu Z.... Li T.	2008	TGFB2
4	Transient increases of glutamic acid decarboxylase 67 immunoreactivity and its protein levels in the somatosensory cortex after transient cerebral ischemia in gerbils. (18840981)	Hwang I.K.... Won M.H.	2008	GAD1
5	Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)	Wen Y.... Simpkins J.W.	2007	CDK5
6	Development of a systemically-active dual CXCR1/CXCR2 allosteric inhibitor and its efficacy in a model of transient cerebral ischemia in the rat. (16613761)	Garau A.... Villa P.	2006	CXCR2
7	Differential effects and changes of ceruloplasmin in the hippocampal CA1 region between adult and aged gerbils after transient cerebral ischemia. (16542745)	Yoo K.Y.... Won M.H.	2006	CP
8	Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. (15837573)	Wei L.... Choi D.W.	2005	BCL2
9	Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus. (15710244)	Dl/uzniewska J.... Zabl/ocka B.	2005	BAD
10	Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. (15353210)	Wen Y.... Simpkins J.W.	2004	MAPT
11	Alterations of N-ethylmaleimide-sensitive atpase following transient cerebral ischemia. (15464284)	Liu C.... Hu B.	2004	NSF
12	Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. (14982935)	Wen Y.... Simpkins J.W.	2004	MAPT
13	Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. (14580322)	Adibhatla R.M.... Dempsey R.J.	2003	PLA2G2A
14	Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. (12812761)	Trapp T.... Lindholm D.	2003	CASP3, XIAP
15	Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia. (12121485)	Sun F.Y.... Gu J.	2002	ERCC6
16	Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. (11672836)	Candelario-Jalil E.... LeA^n O.S.	2001	SOD1, SOD2, GSR
17	Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. (11487731)	Pei L.... Gurd J.W.	2001	SYNGAP1, DLGAP4
18	Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. (11588329)	Adibhatla R.M.... Dempsey R.J.	2001	GSR
19	NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. (11478920)	Liu Y.... Hou X.	2001	GRIN2A, PTK2B
20	Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia. (11222999)	Hayashi Y.... Maeda M.	2001	CASP1
21	Differential expression of HSC73 and HSP72 mRNA and proteins between young and adult gerbils after transient cerebral ischemia: relation to neuronal vulnerability. (10908039)	Bertrand N.... Spatz M.	2000	HSPA1A
22	Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. (10492517)	Rao A.M.... Dempsey R.J.	1999	ALOX5
23	Immunoelectron microscopic study of c-Fos, c-Jun and heat shock protein after transient cerebral ischemia in gerbils. (9930891)	Tomimoto H.... Yanagihara T.	1999	FOS, JUN, HSPA4
24	Changes in IP3R1 and SERCA2b mRNA levels in the gerbil brain after chronic ethanol administration and transient cerebral ischemia-reperfusion. (9602035)	Xia J.... Sun G.Y.	1998	ITPR1
25	Protein kinase C-like immunoreactivity in gerbil hippocampus after a transient cerebral ischemia. (7958073)	Gajkowska B.... Viron A.	1994	DYT10
26	Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia. (8417138)	Saito K.... Heyes M.P.	1993	KYNU, IDO1, KMO
27	Autoradiographic analysis of dopamine D1 receptors in the gerbil brain following transient cerebral ischemia. (1487117)	Araki T.... Kogure K.	1992	DRD1
28	Hyperglycemia suppresses c-fos mRNA expression following transient cerebral ischemia in gerbils. (1727138)	Combs D.J.... Kindy M.S.	1992	FOS
29	Immunoelectron microscopic study of tubulin and micro tubule-associated proteins after transient cerebral ischemia in gerbils. (1441921)	Tomimoto H.... Yanagihara T.	1992	MAP1A, TUBA1B
30	Activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in transient cerebral ischemia: relationship to the duration of vascular occlusion. (1499693)	Rohn G.... Paschen W.	1992	ODC1, AMD1

Genes related to transient cerebral ischemia according to GeneCards:

(show top 50)    (show all 51)

id	Symbol	Description	Score	GeneCards Section Context
1	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	11.0	Publications
2	BAD	BCL2-associated agonist of cell death	11.0	Publications
3	DRD1	dopamine receptor D1	11.0	Publications
4	KYNU	kynureninase	11.0	Publications
5	PVALB	parvalbumin	11.0
6	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
7	ODC1	ornithine decarboxylase 1	11.0	Publications
8	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
9	ADORA1	adenosine A1 receptor	11.0
10	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	11.0
11	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Publications
12	HSPA4	heat shock 70kDa protein 4	11.0	Publications
13	MAP2	microtubule-associated protein 2	11.0
14	RPS27A	ribosomal protein S27a	11.0
15	KIAA1147	KIAA1147	11.0	Functions
16	RAB33B	RAB33B, member RAS oncogene family	11.0	Disorders
17	MAP1A	microtubule-associated protein 1A	11.0	Publications
18	SYNGAP1	synaptic Ras GTPase activating protein 1	11.0	Publications
19	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4	11.0
20	SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	11.0
21	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	11.0
22	AMD1	adenosylmethionine decarboxylase 1	11.0	Publications
23	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	11.0
24	TUBA1B	tubulin, alpha 1b	11.0	Publications
25	CXCR2	chemokine (C-X-C motif) receptor 2	11.0	Publications
26	SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	11.0
27	DLGAP4	discs, large (Drosophila) homolog-associated protein 4	11.0	Publications
28	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	11.0	Publications
29	NSF	N-ethylmaleimide-sensitive factor	11.0	Publications
30	XIAP	X-linked inhibitor of apoptosis	11.0	Publications
31	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	11.0	Publications
32	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications
33	CDK5	cyclin-dependent kinase 5	11.0	Publications
34	CTSD	cathepsin D	11.0	Publications
35	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
36	GSR	glutathione reductase	11.0	Publications
37	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
38	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	11.0	Publications
39	TGFB2	transforming growth factor, beta 2	11.0	Publications
40	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
41	CP	ceruloplasmin (ferroxidase)	11.0	Publications
42	PTK2B	PTK2B protein tyrosine kinase 2 beta	11.0	Publications
43	MAPT	microtubule-associated protein tau	11.0	Publications
44	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
45	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
46	SOD1	superoxide dismutase 1, soluble	11.0	Publications
47	JUN	jun proto-oncogene	11.0	Publications
48	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	11.0	Publications
49	GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	11.0	Publications
50	DYT10	dystonia 10	11.0	Publications

Pathways related to transient cerebral ischemia according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.5	BAD, FOS, TGFB2
2	Tryptophan metabolism20	10.3	HAAO, KYNU, KMO, IDO1
3	ErbB2-ErbB3 Heterodimers36	10.2	ITPR1, BAD
4	NAD metabolism41	10.2	HAAO, KYNU, KMO, IDO1
5	NAD metabolism10	10.2	HAAO, KYNU, KMO, IDO1
6	Metabolism of amino acids and derivatives38	10.2	HAAO, KYNU, KMO, ODC1, AMD1, IDO1
7	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.1	CDK5, BAD, BCL2
8	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	10.1	TUBA1B, CASP1, HSPA4, HSPA1A, HSPA5
9	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	10.1	TUBA1B, CASP1, HSPA4, HSPA1A, HSPA5
10	Cellular Transformation by HTLV136	10.1	HSPA4, HSPA1A, FOS, JUN
11	TNF-Induced Apoptosis Implicating Sphingolipids36	10.0	CTSD, CASP1, CASP3, BAD
12	Development_Glucocorticoid receptor signaling41	9.9	HSPA4, HSPA1A, HSPA5, FOS, JUN
13	Development Glucocorticoid receptor signaling10	9.9	HSPA4, HSPA1A, HSPA5, FOS, JUN
14	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)41	9.8	CP, SOD1, HSPA4, HSPA1A, HSPA5
15	Development_G-Proteins mediated regulation MARK-ERK signaling41	9.7	SYNGAP1, PTK2B, CAMK2G, FOS, ITPR1
16	Development G-Proteins mediated regulation MARK-ERK signaling10	9.7	SYNGAP1, PTK2B, CAMK2G, FOS, ITPR1
17	Development_Endothelin-1/EDNRA transactivation of EGFR41	9.7	PTK2B, CAMK2G, FOS, ITPR1
18	Development Endothelin-1/EDNRA transactivation of EGFR10	9.7	PTK2B, CAMK2G, FOS, ITPR1
19	Development Angiotensin activation of ERK10	9.7	PTK2B, CAMK2G, FOS, ITPR1
20	Development_Angiotensin activation of ERK41	9.6	PTK2B, CAMK2G, FOS, ITPR1
21	Apoptosis Signaling Pathways37	9.6	CASP3, HSPA4, XIAP, BAD, BCL2
22	Development_ACM2 and ACM4 activation of ERK41	9.6	PTK2B, CAMK2G, FOS, ITPR1
23	Ceramide Pathway36	9.5	CTSD, CASP1, CASP3, FOS, JUN, BAD
24	Endothelin-1 Signaling Pathway36	9.5	CASP3, CASP1, PLA2G2A
25	TNF Signaling36	9.5	JUN, FOS, CASP3, CASP1
26	Development ACM2 and ACM4 activation of ERK10	9.5	PTK2B, CAMK2G, FOS, ITPR1
27	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.4	SOD2, FOS, JUN, BCL2
28	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.4	SOD2, FOS, JUN, BCL2
29	Development_Activation of ERK by Alpha-1 adrenergic receptors41	9.4	PTK2B, CAMK2G, FOS, ITPR1, JUN
30	Development Activation of ERK by Alpha-1 adrenergic receptors10	9.4	PTK2B, CAMK2G, FOS, ITPR1, JUN
31	Development Angiotensin signaling via PYK210	9.4	PTK2B, CAMK2G, FOS, ITPR1, JUN
32	Development_Angiotensin signaling via PYK241	9.4	JUN, ITPR1, FOS, CAMK2G, PTK2B
33	Epithelial cell signaling in Helicobacter pylori infection20	9.4	ATP6V0D1, JUN, CASP3, CXCR2
34	GnRH signaling pathway20	9.3	JUN, ITPR1, CAMK2G, PTK2B, PLA2G2A
35	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.3	CASP3, CDK5, JUN, BAD, BCL2
36	Apoptosis and Autophagy3	9.3	CTSD, CASP1, CASP3, XIAP, BAD, BCL2
37	Apoptosis and survival_TNFR1 signaling pathway41	9.3	CASP3, JUN, XIAP, BCL2
38	Tuberculosis20	9.3	TGFB2, CTSD, CAMK2G, CASP3, ATP6V0D1, BAD
39	Apoptosis and survival TNFR1 signaling pathway10	9.2	CASP3, JUN, XIAP, BCL2
40	Pathways in cancer20	9.2	CASP3, FOS, JUN, BAD, BCL2
41	14-3-3 Induced Apoptosis36	9.2	CASP1, CASP3, FOS, JUN, BAD, BCL2
42	MAPK signaling pathway20	9.2	TGFB2, PLA2G2A, CASP3, HSPA1A, MAPT, FOS
43	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling10	9.1	CDK5, ITPR1, GRIN2A, DRD1
44	Toxoplasmosis20	9.1	TGFB2, PLA2G2A, CASP3, HSPA1A, ALOX5, XIAP
45	DHA Signaling36	9.1	TGFB2, PLA2G2A, CASP1, CASP3, MAPT, BAD
46	Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling41	9.0	DRD1, GRIN2A, ITPR1, CDK5
47	Amyotrophic lateral sclerosis (ALS)20	8.7	SOD1, CASP1, CASP3, GRIN2A, BAD, BCL2
48	Alzheimers disease20	8.7	CASP3, MAPT, GRIN2A, ITPR1, CDK5, BAD
49	Pathogenesis of ALS36	8.6	BCL2, SLC1A1, SOD1, CASP1, CASP3, GRIN2A
50	Neuroscience3	8.0	GAD1, SOD1, NSF, SYNGAP1, TUBA1B, CAMK2G

Compounds related to transient cerebral ischemia according to GeneDecks:

(show top 50)    (show all 269)

id	Compound	Score	Top Affiliating Genes
1	egcg32	9.6	SOD1, TGFB2, ODC1, XIAP, PTK2B
2	n acetylcysteine32	9.5	ODC1, RPS27A, PTK2B, ALOX5, MAPT, FOS
3	alanine32	9.4	NSF, SLC1A1, KYNU, ADORA1, CXCR2, PLA2G2A
4	aspartate32	9.3	SOD2, RPS27A, PVALB, SLC1A1, CASP1, ALOX5
5	nitric oxide32 9 18 9	11.8	NSF, BAD, MAP2, IDO1, AMD1, CASP1
6	6-hydroxydopamine32	8.8	FOS, DRD1, CDK5, SOD2, GSR, CASP3
7	h2o232	8.6	BAD, CDK5, MAPT, ALOX5, HSPA1A, CASP1
8	ascorbic acid32 18	9.6	TGFB2, PLA2G2A, CTSD, SOD2, ODC1, HSPA4
9	ly29400232	8.6	PLA2G2A, BAD, ITPR1, SOD2, CASP3, CAMK2G
10	rotenone32	8.5	SOD2, SOD1, RPS27A, CASP1, CASP3, HSPA4
11	alpha tocopherol32	8.5	SOD2, ALOX5, PTK2B, SOD1, PLA2G2A, CTSD
12	c2ceramide32	8.4	CTSD, JUN, SOD2, DYT10, CASP3, HSPA4
13	sb 20358032 42	9.4	BCL2, FOS, ALOX5, HSPA5, CASP3, CASP1
14	dopamine32 9 18 9	11.1	CDK5, FOS, GRIN2A, MAPT, MAP2, HSPA5
15	4-hydroxynonenal32 18	9.1	PLA2G2A, ODC1, CASP1, CASP3, HSPA4, MAPT
16	estrogen32	8.0	GSR, MAPT, MAP2, ALOX5, HSPA5, HSPA1A
17	gf 109203x32 42	8.9	CAMK2G, PLA2G2A, PTK2B, ALOX5, JUN, FOS
18	adriamycin32	7.9	CTSD, ODC1, CASP1, CASP3, SOD1, HSPA4
19	kainate32	7.9	GAD1, CAMK2G, HSPA4, HSPA1A, MAP2, MAPT
20	curcumin32	7.9	XIAP, JUN, BCL2, ALOX5, HSPA4, CASP3
21	etoposide32 42 9 9	10.9	XIAP, BCL2, TUBA1B, JUN, HSPA1A, SOD2
22	cysteine32	7.8	XIAP, MAPT, HSPA5, GAD1, CASP3, DRD1
23	paclitaxel32 34 9 9	10.8	ODC1, CDK5, BCL2, BAD, XIAP, MAPT
24	quercetin32 42 9 18 9	11.8	PTK2B, BAD, JUN, GSR, ALOX5, HSPA1A
25	glutamine32	7.8	SOD2, CDK5, MAPT, HSPA5, HSPA1A, HSPA4
26	doxorubicin32 34 9 9	10.7	TUBA1B, BCL2, RPS27A, CTSD, ODC1, CASP1
27	cyclosporin a32 42	8.7	BAD, TGFB2, RPS27A, PLA2G2A, CTSD, ODC1
28	butyrate32	7.7	JUN, ODC1, MAPT, SOD2, FOS, XIAP
29	arsenite32 18	8.6	RPS27A, SOD1, PTK2B, BCL2, XIAP, JUN
30	lactate32	7.6	HSPA5, HSPA4, MAP2, CASP3, CASP1, RPS27A
31	staurosporin32	7.6	JUN, CASP3, CASP1, DYT10, PTK2B, PLA2G2A
32	cisplatin32 34 9 9	10.4	SOD2, RPS27A, CTSD, PTK2B, TUBA1B, CAMK2G
33	atp32	7.4	ADORA1, PVALB, CDK5, NSF, MAP2, HSPA1A
34	superoxide32 18	8.2	SOD2, SOD1, CXCR2, PLA2G2A, PTK2B, TUBA1B
35	thapsigargin32 42	8.1	PTK2B, HSPA5, CASP1, BCL2, ITPR1, ALOX5
36	pd 98,05932	7.1	PTK2B, DYT10, BCL2, BAD, CDK5, FOS
37	pdtc32	7.0	BCL2, XIAP, JUN, FOS, CASP3, DYT10
38	oxygen32 18	7.9	GSR, MAP2, ALOX5, HSPA5, HSPA1A, CASP3
39	dexamethasone32 42 34 9 9	10.5	ITPR1, JUN, XIAP, BAD, BCL2, ADORA1
40	calcium32 9 18 9	9.5	CAMK2G, DRD1, PTK2B, CTSD, PLA2G2A, TGFB2
41	actinomycin d32	6.5	PLA2G2A, ODC1, PTK2B, DYT10, CAMK2G, CASP1
42	phosphatidylinositol32	6.0	DRD1, CDK5, SLC1A1, JUN, XIAP, FOS
43	genistein32 9 18 9	8.9	BCL2, JUN, FOS, GSR, MAPT, ADORA1
44	cycloheximide32	5.7	BCL2, DYT10, ODC1, CTSD, PLA2G2A, RPS27A
45	vegf32	5.6	BCL2, XIAP, RPS27A, TGFB2, CXCR2, SOD2
46	nmda32 42	6.2	ADORA1, GAD1, CAMK2G, DYT10, DRD1, PTK2B
47	retinoic acid32 42 18	7.1	CDK5, PLA2G2A, RPS27A, TGFB2, CXCR2, SLC1A1
48	tyrosine32	5.0	CAMK2G, TUBA1B, DYT10, DRD1, PTK2B, ODC1
49	glutamate32	4.7	CDK5, ITPR1, FOS, GSR, GRIN2A, MAPT
50	serine32	4.1	CAMK2G, CP, TUBA1B, DYT10, DRD1, PTK2B

Cellular components related to transient cerebral ischemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	9.6	CDK5, MAPT, DRD1, TGFB2, PVALB
2	neuronal cell body	GO:043025	8.9	ADORA1, SOD1, TGFB2, DLGAP4, DRD1, MAP2
3	cytosol	GO:005829	5.6	BCL2, CASP1, CAMK2G, PTK2B, ODC1, RPS27A

Biological processes related to transient cerebral ischemia according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	tryptophan catabolic process to kynurenine	GO:019441	10.4	KYNU, KMO, IDO1
2	NAD biosynthetic process	GO:009435	10.4	HAAO, KYNU, KMO
3	tryptophan catabolic process	GO:006569	10.3	HAAO, KYNU, KMO, IDO1
4	quinolinate biosynthetic process	GO:019805	10.2	KYNU, HAAO
5	regulation of synaptic plasticity	GO:048167	10.1	ADORA1, SYNGAP1, CDK5
6	cellular nitrogen compound metabolic process	GO:034641	10.0	HAAO, KYNU, KMO, ODC1, AMD1, IDO1
7	response to superoxide	GO:000303	9.9	ERCC6, SOD1, SOD2
8	visual learning	GO:008542	9.8	CDK5, GRIN2A, DRD1, SYNGAP1
9	regulation of long-term neuronal synaptic plasticity	GO:048169	9.7	GRIN2A, DRD1, SYNGAP1
10	regulation of excitatory postsynaptic membrane potential	GO:060079	9.7	ADORA1, GRIN2A, CDK5
11	cellular response to organic substance	GO:071310	9.6	CASP1, CASP3, MAP2, BCL2
12	response to heat	GO:009408	9.6	SOD1, DNAJA4, HSPA4, BCL2
13	induction of apoptosis by intracellular signals	GO:008629	9.5	CASP3, XIAP, BAD, BCL2
14	cellular response to lipid	GO:071396	9.5	BAD, GRIN2A
15	positive regulation of neuron apoptotic process	GO:043525	9.5	TGFB2, CASP3, CDK5, JUN
16	response to amphetamine	GO:001975	9.4	GRIN2A, DRD1, SOD1
17	release of cytochrome c from mitochondria	GO:001836	9.1	BCL2, JUN, CASP3, SOD2
18	response to hypoxia	GO:001666	9.1	ADORA1, TGFB2, CAMK2G, CASP1, ITPR1, BCL2
19	apoptotic process	GO:006915	8.4	CXCR2, RPS27A, PTK2B, CASP1, CASP3, MAPT
20	negative regulation of apoptotic process	GO:043066	8.4	BCL2, ADORA1, SOD2, SYNGAP1, TGFB2, PTK2B
21	response to drug	GO:042493	8.1	GAD1, SOD1, TGFB2, DRD1, CASP1, GRIN2A

Molecular functions related to transient cerebral ischemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	superoxide dismutase activity	GO:004784	9.7	SOD1, SOD2
2	protein binding	GO:005515	3.6	BCL2, ERCC6, TUBA1B, DRD1, PTK2B, DLGAP4