MCID: TRN015
MIFTS: 44

Transient Cerebral Ischemia malady

Summaries for Transient Cerebral Ischemia

About this section


MedlinePlus:32 A transient ischemic attack (tia) is a stroke that comes and goes quickly. it happens when the blood supply to part of the brain stops briefly. symptoms of a tia are like other stroke symptoms, but do not last as long. they happen suddenly, and include numbness or weakness, especially on one side of the body confusion or trouble speaking or understanding speech trouble seeing in one or both eyes loss of balance or coordination most symptoms of a tia disappear within an hour, although they may last for up to 24 hours. because you cannot tell if these symptoms are from a tia or a stroke, you should get to the hospital quickly. tias are often a warning sign for future strokes. taking medicine, such as blood thinners, may reduce your risk of a stroke. your doctor might also recommend surgery. nih: national institute of neurological disorders and stroke

MalaCards based summary: Transient Cerebral Ischemia, also known as transient ischemic attack, is related to ischemia and atrial fibrillation. An important gene associated with Transient Cerebral Ischemia is DRD1 (dopamine receptor D1), and among its related pathways are Tryptophan metabolism and tryptophan utilization II. The compounds 3-hydroxykynurenine and Hydroxykynurenine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord.

NINDS:42 A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination.

Wikipedia:63 A transient ischemic attack (TIA) is a transient episode of neurologic dysfunction caused by ischemia... more...

Aliases & Classifications for Transient Cerebral Ischemia

About this section

Transient Cerebral Ischemia, Aliases & Descriptions:

Name: Transient Cerebral Ischemia 9 11 43 60
Transient Ischemic Attack 9 42 43 32 60
Transient Cerebral Ischaemia Nos 9
Tia - Transient Ischaemic Attack 9
 
Transient Cerebral Ischaemia 9
Transient Ischemic Attacks 9
Tia 9


External Ids:

Disease Ontology9 DOID:224
NCIt38 C50781
MeSH33 D002546

Related Diseases for Transient Cerebral Ischemia

About this section

Diseases related to Transient Cerebral Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.5KMO, ADORA1, PLA2G2A, CAMK2G
2atrial fibrillation30.6CAMK2G, ADORA1
3brain ischemia30.5ADORA1, CAMK2G
4tauopathy30.4CAMK2G, RPS27A
5stroke, ischemic29.6ADORA1, PLA2G2A, CAMK2G, ODC1
6cerebritis11.5
7neuronitis11.1
8patent foramen ovale10.7
9carotid stenosis10.6
10endotheliitis10.5
11moyamoya disease10.5
12carotid artery occlusion10.4
13artery disease10.4
14carotid artery disease10.4
15mini stroke10.4
16hyperglycemia10.4
17schimke immunoosseous dysplasia10.4
18peripheral vascular disease10.4
19deficiency anemia10.4
20iron deficiency anemia10.4
21protein c deficiency10.4
22cerebrovascular disease10.4
23periodontitis10.4
24fibromuscular dysplasia10.4
25aneurysm10.4
26atrial septal aneurysm10.4
27striatonigral degeneration10.3RPS27A
28migraine10.3
29cerebral amyloid angiopathy10.3
30brain injury10.3
31hypoxia10.3
32systemic lupus erythematosus10.2
33telangiectasia, hereditary hemorrhagic, type 410.2
34telangiectasia, hereditary hemorrhagic, type 210.2
35moyamoya disease 210.2
36myocardial infarction10.2
37telangiectasia, hereditary hemorrhagic, type 110.2
38cerebral hemorrhage10.2
39hemolytic anemia10.2
40leukemia10.2
41ulcerative colitis10.2
42antiphospholipid syndrome10.2
43homocystinuria10.2
44leukostasis10.2
45petroclival meningioma10.2
46peripartum cardiomyopathy10.2
47pseudotumor cerebri10.2
48cerebral artery occlusion10.2
49arteriovenous malformation10.2
50prosopagnosia10.2

Graphical network of the top 20 diseases related to Transient Cerebral Ischemia:



Diseases related to transient cerebral ischemia

Symptoms for Transient Cerebral Ischemia

About this section

Drugs & Therapeutics for Transient Cerebral Ischemia

About this section

Drug clinical trials:

Search ClinicalTrials for Transient Cerebral Ischemia

Search NIH Clinical Center for Transient Cerebral Ischemia

Genetic Tests for Transient Cerebral Ischemia

About this section

Anatomical Context for Transient Cerebral Ischemia

About this section

MalaCards organs/tissues related to Transient Cerebral Ischemia:

31
Brain, Eye, Spinal cord, Endothelial, Cortex, Olfactory bulb, Bone marrow, Bone, Spleen, Thyroid, Testes

Animal Models for Transient Cerebral Ischemia or affiliated genes

About this section

Publications for Transient Cerebral Ischemia

About this section

Articles related to Transient Cerebral Ischemia:

(show top 50)    (show all 401)
idTitleAuthorsYear
1
Accelerated and exacerbated effects of high dietary fat on neuronal damage induced by transient cerebral ischemia in the gerbil septum. (25309792)
2014
2
Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. (24321754)
2013
3
Comparison of inflammatory cytokines changes in the hippocampal CA1 region between the young and adult gerbil after transient cerebral ischemia. (22578357)
2012
4
Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. (22052512)
2012
5
EAAC1 gene deletion alters zinc homeostasis and enhances cortical neuronal injury after transient cerebral ischemia in mice. (22575539)
2012
6
Time-course alterations of Toll-like receptor 4 and NF-I_B p65, and their co-expression in the gerbil hippocampal CA1 region after transient cerebral ischemia. (21842272)
2011
7
Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. (21472764)
2011
8
Relation among neuronal death, cell proliferation and neuronal differentiation in the gerbil main olfactory bulb after transient cerebral ischemia. (20405201)
2010
9
2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats. (20840843)
2010
10
DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. (18854841)
2009
11
Reduced neurogenesis after suppressed inflammation by minocycline in transient cerebral ischemia in rat. (19185320)
2009
12
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. (17113760)
2007
13
Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. (17391653)
2007
14
Postprandial limb-shaking: an unusual presentation of transient cerebral ischemia. (16763755)
2006
15
Co-translational protein aggregation after transient cerebral ischemia. (16039801)
2005
16
Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils. (15338328)
2004
17
Decrease of PKC precedes other cellular signs of calpain activation in area CA1 of the hippocampus after transient cerebral ischemia. (12427474)
2003
18
Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. (14753432)
2003
19
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia. (14580322)
2003
20
Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia. (12812761)
2003
21
A new method of inducing selective brain hypothermia with saline perfusion into the subdural space: effects on transient cerebral ischemia in cats. (12685856)
2002
22
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. (11821016)
2002
23
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. (11672836)
2001
24
Protective effects of SM-20302, an orally active GPIIb/IIIa antagonist, in an ADP/epinephrine-induced guinea pig model of transient cerebral ischemia. (11228335)
2001
25
NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. (11478920)
2001
26
Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. (11090993)
2000
27
Effects of felbamate on brain polyamine changes following transient cerebral ischemia in the Mongolian gerbil. (11083508)
2000
28
Immunocytochemical localization of endothelial nitric oxide synthase (e-NOS) and inducible nitric oxide synthase (i-NOS) in rat neurohypophysis after transient cerebral ischemia. (10337059)
1999
29
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
30
Decreased expression and functionality of NMDA receptor complexes persist in the CA1, but not in the dentate gyrus after transient cerebral ischemia. (9663507)
1998
31
Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. (9591847)
1998
32
Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. (9634557)
1998
33
The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. (9838092)
1998
34
Expression of Ca2+-dependent (classical) PKC mRNA isoforms after transient cerebral ischemia in gerbil hippocampus. (9473687)
1998
35
Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. (9493961)
1997
36
Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. (9347348)
1997
37
The effect of hypothermia on protein synthesis and the expression of immediate early genes following transient cerebral ischemia. (8790800)
1996
38
A new model of transient cerebral ischemia in neonatal rats. (8594055)
1996
39
Disruption of the blood-cerebrospinal fluid barrier by transient cerebral ischemia. (8137165)
1994
40
Regional [14C]palmitate incorporation into the hippocampus after transient cerebral ischemia in awake gerbils. (2396510)
1990
41
Effects of transient cerebral ischemia on the hippocampal dentate theta (theta) profile in the acute rat: a study 4-5 months following recirculation. (2337781)
1990
42
Immunocytochemical investigation of L-glutamic acid decarboxylase in the rat hippocampal formation: the influence of transient cerebral ischemia. (2925901)
1989
43
Hippocampal unit activity after transient cerebral ischemia in rats. (2547253)
1989
44
Selective neuronal vulnerability following transient cerebral ischemia in the gerbil: distribution and time course. (2618582)
1989
45
Transient cerebral ischemia: diagnostic considerations. (6987710)
1980
46
Management of transient cerebral ischemia. (573393)
1979
47
Use of a computerized information system in the management of patients with transient cerebral ischemia. (571065)
1979
48
Plasma lipids and lipoproteins in patients with cerebral infarct or transient cerebral ischemia. (222104)
1979
49
Platelet aggregation and fibrinolytic activity in transient cerebral ischemia. (842281)
1977
50
Transient cerebral ischemia. Prevalence and prognosis in a biracial rural community. (4740273)
1973

Variations for Transient Cerebral Ischemia

About this section

Expression for genes affiliated with Transient Cerebral Ischemia

About this section
Search GEO for disease gene expression data for Transient Cerebral Ischemia.

Pathways for genes affiliated with Transient Cerebral Ischemia

About this section

Pathways related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7KYNU, KMO
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.7KYNU, KMO
3
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde36
NAD salvage36
NAD metabolism58
9.7KMO, KYNU
4
Show member pathways
thioredoxin pathway36
9.7KMO, KYNU
5
Show member pathways
9.3CAMK2G, DRD1
6
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
9.2KMO, KYNU, ODC1
7
Show member pathways
9.0DRD1, ADORA1, PLA2G2A
8
Show member pathways
8.8ADORA1, CAMK2G, DRD1
9
Show member pathways
8.1RPS27A, KMO, KYNU, PLA2G2A, ODC1

Compounds for genes affiliated with Transient Cerebral Ischemia

About this section

Compounds related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
13-hydroxykynurenine4310.1KMO, KYNU
2Hydroxykynurenine2410.1KMO, KYNU
3L-Kynurenine2410.1KMO, KYNU
4kynurenic acid43 28 2412.1KYNU, KMO
53-hydroxyanthranilic acid43 2411.1KMO, KYNU
6n6-cyclopentyladenosine43 5911.0ADORA1, DRD1
7kynurenine4310.0KYNU, KMO
8sulpiride43 28 1212.0DRD1, ODC1
9indoleamine439.9KYNU, KMO
10quinolinic acid43 2410.9KMO, KYNU
11l-tryptophan49 28 43 24 1213.8KMO, KYNU
12dicoumarol439.7RPS27A, ODC1
13melittin439.7RPS27A, PLA2G2A
14formaldehyde43 2410.4DRD1, RPS27A, ADORA1
15atpgammas43 2810.4CAMK2G, ADORA1
164-hydroxynonenal43 2410.3ODC1, RPS27A, PLA2G2A
17levodopa43 1210.2RPS27A, DRD1, CAMK2G
18carbachol43 28 1211.1DRD1, ADORA1, CAMK2G
19diisopropylfluorophosphate439.1CAMK2G, ODC1
20n acetylcysteine439.1ODC1, RPS27A, PLA2G2A
21herbimycin a43 5910.0CAMK2G, RPS27A, ODC1
22isoproterenol43 1210.0CAMK2G, ODC1, ADORA1
23genistein43 28 59 2 24 1213.9PLA2G2A, ADORA1, DRD1, ODC1
245-hydroxytryptamine438.9PLA2G2A, CAMK2G, ADORA1
25norepinephrine43 24 1210.8CAMK2G, ADORA1, DRD1
26aspirin43 49 28 2411.8ODC1, ADORA1, PLA2G2A, RPS27A
27kainate43 289.8CAMK2G, ODC1, ADORA1, DRD1
28cocaine43 129.8CAMK2G, ADORA1, ODC1, DRD1
29ibmx43 59 2810.8DRD1, CAMK2G, ADORA1, ODC1
30estrogen438.7DRD1, ODC1, ADORA1, RPS27A
31guanine43 24 1210.7CAMK2G, DRD1, RPS27A, ADORA1
32gaba438.7ADORA1, RPS27A, DRD1, CAMK2G
33gnrh438.7CAMK2G, PLA2G2A, ODC1, DRD1
34histamine43 28 2410.5ADORA1, ODC1, CAMK2G, PLA2G2A
35actinomycin d438.5PLA2G2A, RPS27A, CAMK2G, ODC1
36cyclosporin a43 28 5910.4PLA2G2A, ODC1, CAMK2G, RPS27A
37cycloheximide438.4RPS27A, CAMK2G, PLA2G2A, ODC1
38h2o2438.4PLA2G2A, ODC1, RPS27A, CAMK2G
39dexamethasone43 49 28 1211.3ADORA1, PLA2G2A, CAMK2G, RPS27A
40atp43 289.3RPS27A, CAMK2G, DRD1, ADORA1
41cysteine438.2DRD1, PLA2G2A, RPS27A, ODC1
42tyrosine438.2RPS27A, CAMK2G, DRD1, KYNU, ODC1
43retinoic acid43 249.1RPS27A, PLA2G2A, CAMK2G, ODC1
44acetylcholine43 49 28 24 1212.1ADORA1, PLA2G2A, RPS27A, CAMK2G, DRD1
45alanine438.0KYNU, ADORA1, RPS27A, CAMK2G, PLA2G2A
46dopamine43 28 24 1210.6PLA2G2A, RPS27A, ADORA1, CAMK2G, ODC1, DRD1
47adenylate437.6RPS27A, CAMK2G, ADORA1, DRD1, ODC1, PLA2G2A
48serine437.6ADORA1, ODC1, PLA2G2A, RPS27A, CAMK2G, DRD1
49nmda43 288.3ODC1, KMO, ADORA1, DRD1, CAMK2G, RPS27A
50glutamate437.3DRD1, CAMK2G, RPS27A, PLA2G2A, ODC1, ADORA1

GO Terms for genes affiliated with Transient Cerebral Ischemia

About this section

Cellular components related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:00306669.1CAMK2G, RPS27A
2cytosolGO:00058297.6CAMK2G, RPS27A, KMO, KYNU, ODC1

Biological processes related to Transient Cerebral Ischemia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1quinolinate biosynthetic processGO:00198059.9KMO, KYNU
2tryptophan catabolic process to kynurenineGO:00194419.9KMO, KYNU
3tryptophan catabolic processGO:00065699.8KYNU, KMO
4positive regulation of potassium ion transportGO:00432689.8DRD1, ADORA1
5NAD biosynthetic processGO:00094359.7KMO, KYNU
6temperature homeostasisGO:00016599.5DRD1, ADORA1
7lipid catabolic processGO:00160429.3PLA2G2A, ADORA1
8cellular nitrogen compound metabolic processGO:00346418.9ODC1, KYNU, KMO
9small molecule metabolic processGO:00442818.2ODC1, KYNU, KMO, PLA2G2A, RPS27A

Products for genes affiliated with Transient Cerebral Ischemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Transient Cerebral Ischemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet