MCID: TRN030
MIFTS: 36

Transient Erythroblastopenia of Childhood

Categories: Rare diseases, Immune diseases, Blood diseases, Genetic diseases

Aliases & Classifications for Transient Erythroblastopenia of Childhood

MalaCards integrated aliases for Transient Erythroblastopenia of Childhood:

Name: Transient Erythroblastopenia of Childhood 53 72 49 55 13
Erythroblastopenia, Transient 53 49 51
Transient Acquired Pure Red Cell Aplasia 55 69
Tec 53 49
Familial Transient Erythroblastopenia of Childhood 49

Characteristics:

OMIM:

53
Inheritance:
autosomal recessive


HPO:

31
transient erythroblastopenia of childhood:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 53 227050
Orphanet 55 ORPHA98871
MESH via Orphanet 42 C536980
UMLS via Orphanet 70 C0238478
ICD10 via Orphanet 33 D60.1
MedGen 39 C0238478
ICD10 32 D60.1
SNOMED-CT via HPO 65 258211005
UMLS 69 C0451688

Summaries for Transient Erythroblastopenia of Childhood

OMIM : 53 Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most commonly between 6 months and 4 years of age. The course is characterized by a complete recovery, usually within 1 to 2 months after diagnosis. In most cases no therapy is necessary, although some children may need red cell transfusion (summary by Gustavsson et al., 2002). (227050)

MalaCards based summary : Transient Erythroblastopenia of Childhood, also known as erythroblastopenia, transient, is related to congenital hypoplastic anemia and aplastic anemia, and has symptoms including transient erythroblastopenia An important gene associated with Transient Erythroblastopenia of Childhood is TEC (Tec Protein Tyrosine Kinase), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone marrow, bone and neutrophil.

Wikipedia : 72 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Related Diseases for Transient Erythroblastopenia of Childhood

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to Transient Erythroblastopenia of Childhood

Symptoms & Phenotypes for Transient Erythroblastopenia of Childhood

Symptoms via clinical synopsis from OMIM:

53
Heme:
transient erythroblastopenia
anemia


Clinical features from OMIM:

227050

Human phenotypes related to Transient Erythroblastopenia of Childhood:

31
# Description HPO Frequency HPO Source Accession
1 transient erythroblastopenia 31 HP:0005510

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Search Clinical Trials , NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

38
Bone Marrow, Bone, Neutrophil, T Cells

Publications for Transient Erythroblastopenia of Childhood

Articles related to Transient Erythroblastopenia of Childhood:

(show top 50) (show all 53)
# Title Authors Year
1
Deformation of erythroblasts in transient erythroblastopenia of childhood caused by HHV-6. ( 28092892 )
2016
2
Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. ( 24635829 )
2014
3
Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. ( 22335327 )
2012
4
Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. ( 21730806 )
2011
5
Transient erythroblastopenia of childhood in siblings: case report and review of the literature. ( 17805047 )
2007
6
Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. ( 15956889 )
2005
7
Familial transient erythroblastopenia of childhood is associated with the chromosome 19q13.2 region but not caused by mutations in coding sequences of the ribosomal protein S19 (RPS19) gene. ( 12358933 )
2002
8
Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. ( 11972099 )
2002
9
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. ( 10804733 )
2000
10
Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. ( 9633983 )
1998
11
Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. ( 9674545 )
1998
12
Breath-holding spells in a patient with transient erythroblastopenia of childhood. ( 9108866 )
1997
13
Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. ( 9260752 )
1997
14
Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. ( 9149751 )
1997
15
Glycosylated haemoglobin and transient erythroblastopenia of childhood. ( 8551925 )
1996
16
Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. ( 9025846 )
1996
17
Transient erythroblastopenia of childhood. Prospective study of fifty patients. ( 7978049 )
1994
18
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. ( 7845854 )
1994
19
Transient erythroblastopenia of childhood in infants < 6 months of age. ( 8037344 )
1994
20
Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. ( 8338993 )
1993
21
Transient erythroblastopenia of childhood presenting with echovirus 11 infection. ( 8518530 )
1993
22
Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. ( 8435319 )
1993
23
Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. ( 8214360 )
1993
24
Parvovirus B19 and transient erythroblastopenia of childhood. ( 8518188 )
1993
25
Human parvovirus infection and transient erythroblastopenia of childhood. ( 1327065 )
1992
26
Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. ( 1536802 )
1992
27
Immature lymphocytes in transient erythroblastopenia of childhood. ( 1907620 )
1991
28
Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. ( 2140775 )
1990
29
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. ( 2146287 )
1990
30
Transient erythroblastopenia of childhood: implications for nurse practitioners. ( 2754596 )
1989
31
Transient erythroblastopenia of childhood due to human parvovirus B19 infection. ( 2553096 )
1989
32
Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. ( 2718996 )
1989
33
Reduced neutrophil counts in children with transient erythroblastopenia of childhood. ( 2809908 )
1989
34
AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. ( 2804355 )
1989
35
Seasonal clustering of transient erythroblastopenia of childhood. ( 2829620 )
1988
36
Transient erythroblastopenia of childhood. ( 18750483 )
1988
37
Transient neurological disorder associated with transient erythroblastopenia of childhood. ( 3592128 )
1987
38
Transient erythroblastopenia of childhood presenting with papilledema. ( 3698450 )
1986
39
Transient erythroblastopenia of childhood not associated with human parvovirus infection. ( 2869252 )
1986
40
Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. ( 4013369 )
1985
41
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. ( 2982125 )
1985
42
T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. ( 3871630 )
1985
43
Transient erythroblastopenia of childhood. A review of 22 cases. ( 6593224 )
1984
44
Transient erythroblastopenia of childhood: varied pathogenesis. ( 6846328 )
1983
45
Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). ( 7254949 )
1981
46
Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. ( 7293995 )
1981
47
Nursing care study: transient erythroblastopenia of childhood. ( 6907956 )
1981
48
Transient erythroblastopenia of childhood. ( 7271473 )
1981
49
Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. ( 7254979 )
1981
50
Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. ( 6968143 )
1980

Variations for Transient Erythroblastopenia of Childhood

Expression for Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for Transient Erythroblastopenia of Childhood

GO Terms for Transient Erythroblastopenia of Childhood

Biological processes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 KITLG TEC
2 erythrocyte differentiation GO:0030218 9.16 EPO RPS19
3 positive regulation of DNA replication GO:0045740 8.96 EPO KITLG
4 positive regulation of Ras protein signal transduction GO:0046579 8.62 EPO KITLG

Sources for Transient Erythroblastopenia of Childhood

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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