TEC
MCID: TRN030
MIFTS: 23

Transient Erythroblastopenia of Childhood (TEC) malady

Immune, Blood, Genetic categories

Summaries for Transient Erythroblastopenia of Childhood

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

MalaCards: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to diamond-blackfan anemia and aplastic anemia. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (tec protein tyrosine kinase), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Development EPO-induced Jak-STAT pathway. The compounds cyclosporin a and inositol have been mentioned in the context of this disorder.

Description from OMIM:47 227050

Aliases & Classifications for Transient Erythroblastopenia of Childhood

Sources:
43NIH Rare Diseases, 47OMIM, 49Orphanet, 61UMLS, 45Novoseek, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Immune, Blood


Aliases & Descriptions:

transient erythroblastopenia of childhood 43 47 49 61
transient acquired pure red cell aplasia 49 61
erythroblastopenia, transient 43 45
familial transient erythroblastopenia of childhood 43
decreased erythroid precursor production 61
tec 43


External Ids:

OMIM47 227050
MESH via Orphanet36 C536980
ICD10 via Orphanet26 D60.1
SNOMED-CT via Orphanet58 234375006
UMLS via Orphanet62 C0238478
ICD1025 D60.1

Related Diseases for Transient Erythroblastopenia of Childhood

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1diamond-blackfan anemia30.4RPS19, EPO
2aplastic anemia30.4EPO, RPS19
3myelodysplastic syndromes30.1EPO
4extraskeletal myxoid chondrosarcoma10.4
5hepatitis c10.3
6hepatitis e10.3
7metabolic acidosis10.3
8transient hypogammaglobulinemia10.3
9behcet's disease10.3
10wiskott-aldrich syndrome10.2
11agammaglobulinemia10.1
12b cell deficiency10.1
13squamous cell carcinoma10.1
14t cell deficiency10.1
15gout10.0
16narcolepsy10.0
17allergic asthma10.0
18congenital fibrosarcoma10.0
19autoimmune hemolytic anemia10.0
20asthma10.0
21diamond-blackfan anemia 110.0RPS19, EPO

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to transient erythroblastopenia of childhood

Clinical Features for Transient Erythroblastopenia of Childhood

Sources:
47OMIM
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Clinical features from OMIM:

227050

Clinical synopsis from OMIM:

227050

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

Animal Models for Transient Erythroblastopenia of Childhood or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Transient Erythroblastopenia of Childhood

Genetic Variations for Transient Erythroblastopenia of Childhood

Expression for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1TEC, EPO
2
Development EPO-induced Jak-STAT pathway
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9.1TEC, EPO

Compounds for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclosporin a45 29 6011.1TEC, EPO
2inositol458.8TEC, EPO

GO Terms for genes affiliated with Transient Erythroblastopenia of Childhood

Products for genes affiliated with Transient Erythroblastopenia of Childhood

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Transient Erythroblastopenia of Childhood

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet