Transient Erythroblastopenia of Childhood disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Transient Erythroblastopenia of Childhood

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⁶³Wikipedia, ⁴⁶OMIM, ³²MalaCards
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Wikipedia:⁶³ Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

MalaCards: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to diamond-blackfan anemia and aplastic anemia. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (tec protein tyrosine kinase), and among its related pathways are Signaling events mediated by Stem cell factor receptor (c-Kit) and Development EPO-induced Jak-STAT pathway. The compounds cyclosporin a and inositol have been mentioned in the context of this disorder.

Description from OMIM:⁴⁶ 227050

Aliases & Classifications for Transient Erythroblastopenia of Childhood

Sources:
⁴²NIH Rare Diseases, ⁴⁶OMIM, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet, ²⁵ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Immune diseases, Blood diseases

ICD10: ²⁶ ²⁵

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Aplastic and other anaemias

Acquired pure red cell aplasia [erythroblastopenia]

Transient acquired pure red cell aplasia

Aliases & Descriptions:

transient erythroblastopenia of childhood ⁴² ⁴⁶ ⁴⁸ ⁶⁰

transient acquired pure red cell aplasia ⁴⁸ ⁶⁰

erythroblastopenia, transient ⁴² ⁴⁴

familial transient erythroblastopenia of childhood ⁴²

decreased erythroid precursor production ⁶⁰

tec ⁴²

External Ids:

OMIM⁴⁶ 227050

MESH via Orphanet³⁵ C536980

ICD10 via Orphanet²⁶ D60.1

SNOMED-CT via Orphanet⁵⁷ 234375006

UMLS via Orphanet⁶¹ C0238478

ICD10²⁵ D60.1

Related Diseases for Transient Erythroblastopenia of Childhood

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)

id	Related Disease	Score	Top Affiliating Genes
1	diamond-blackfan anemia	30.4	EPO, RPS19
2	aplastic anemia	30.3	EPO, RPS19
3	myelodysplastic syndromes	30.0	EPO
4	chondrosarcoma	10.4
5	extraskeletal myxoid chondrosarcoma	10.3
6	myxoid chondrosarcoma	10.3
7	metabolic acidosis	10.3
8	congenital hypoplastic anemia	10.3
9	hemolytic anemia	10.3
10	hepatitis	10.3
11	papilledema	10.3
12	transient hypogammaglobulinemia	10.3
13	behcet's disease	10.3
14	b cell deficiency	10.2
15	wiskott-aldrich syndrome	10.1
16	leukemia	10.1
17	agammaglobulinemia	10.1
18	breast cancer	10.1
19	candidiasis	10.1
20	cervical squamous cell carcinoma	10.1
21	cervicitis	10.1
22	lymphedema	10.1
23	squamous cell carcinoma	10.1
24	t cell deficiency	10.1
25	diamond-blackfan anemia 1	10.0	EPO, RPS19
26	gout	9.9
27	narcolepsy	9.9
28	allergic asthma	9.9
29	congenital fibrosarcoma	9.9
30	autoimmune hemolytic anemia	9.9
31	asthma	9.9
32	endometrial carcinoma	9.9
33	fibrosarcoma	9.9
34	inflammatory bowel disease	9.9
35	malaria	9.9
36	multiple myeloma	9.9
37	myeloma	9.9
38	neutropenia	9.9

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:

Clinical Features for Transient Erythroblastopenia of Childhood

Sources:
⁴⁶OMIM
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Clinical features from OMIM:

227050

Clinical synopsis from OMIM:

227050

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

Animal Models for Transient Erythroblastopenia of Childhood or affiliated genes

Publications for Transient Erythroblastopenia of Childhood

Genes related to Transient Erythroblastopenia of Childhood

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁶OMIM
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Genes related to Transient Erythroblastopenia of Childhood:

id	Symbol	Description	Score	Implication
1	TEC	tec protein tyrosine kinase	20.00	Genetic linkage ⁴⁶
2	RPS19	ribosomal protein S19	17.62	GeneCards inferred : Publications, Disorders (show sections)
3	EPO	erythropoietin	12.62	GeneCards inferred : Publications, Disorders (show sections)
4	EGID-100124696	transient erythroblastopenia of childhood	8.04	GeneCards inferred : Publications, Disorders, Gene name (show sections)

Products for genes related to Transient Erythroblastopenia of Childhood disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	3	3	3
2	LSBio	-	-	4

Genetic Variations for Transient Erythroblastopenia of Childhood

Expression for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
³⁷NCBI BioSystems Database, ¹²EMD Millipore
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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Signaling events mediated by Stem cell factor receptor (c-Kit)³⁷ Hide members Kit Receptor Signaling Pathway³⁷	9.1	TEC, EPO
2	Development EPO-induced Jak-STAT pathway Hide members EPO signaling pathway³⁷ EPO Receptor Signaling³⁷ Development EPO-induced Jak-STAT pathway¹²	9.1	TEC, EPO