MCID: TRN030
MIFTS: 34

Transient Erythroblastopenia of Childhood malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases categories

Summaries for Transient Erythroblastopenia of Childhood

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OMIM:45 Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most... (227050) more...

MalaCards based summary: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to aplastic anemia and chondrosarcoma, and has symptoms including autosomal recessive inheritanceand transient erythroblastopenia. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (tec protein tyrosine kinase), and among its related pathways are Kit Receptor Signaling Pathway and Development EPO induced Jak STAT pathway. The compounds phosphatidylinositol and inositol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and t cells, and related mouse phenotype hematopoietic system.

Wikipedia:63 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Aliases & Classifications for Transient Erythroblastopenia of Childhood

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Sources:
45OMIM, 10diseasecard, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 43Novoseek, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Transient Erythroblastopenia of Childhood, Aliases & Descriptions:

Name: Transient Erythroblastopenia of Childhood 45 10 41 47 60
Transient Acquired Pure Red Cell Aplasia 41 47 60
Erythroblastopenia, Transient 41 43
 
Familial Transient Erythroblastopenia of Childhood 41
Tec 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

OMIM45 227050
Orphanet47 98871
MESH via Orphanet34 C536980
ICD10 via Orphanet26 D60.1
UMLS via Orphanet61 C0238478
ICD1025 D60.1

Related Diseases for Transient Erythroblastopenia of Childhood

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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia30.0RPS19, EPO
2chondrosarcoma10.4
3myxoid chondrosarcoma10.4
4behcet's disease10.3
5hemolytic anemia10.3
6hepatitis10.3
7metabolic acidosis10.3
8congenital hypoplastic anemia10.3
9papilledema10.3
10transient hypogammaglobulinemia10.3
11b cell deficiency10.2
12asthma10.0
13myelodysplastic syndrome10.0
14multiple myeloma10.0
15neutropenia10.0
16allergic asthma10.0
17autoimmune hemolytic anemia10.0
18candidiasis10.0
19myeloma10.0
20endotheliitis10.0
21deficiency anemia9.8RPS19, EPO
22diamond-blackfan anemia9.8EPO, RPS19

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to transient erythroblastopenia of childhood

Symptoms for Transient Erythroblastopenia of Childhood

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Symptoms by clinical synopsis from OMIM:

227050

Clinical features from OMIM:

227050

HPO human phenotypes related to Transient Erythroblastopenia of Childhood:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 transient erythroblastopenia HP:0005510

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

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Drug clinical trials:

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Search NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

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Anatomical Context for Transient Erythroblastopenia of Childhood

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MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

31
Bone marrow, Bone, T cells, Neutrophil

Animal Models for Transient Erythroblastopenia of Childhood or affiliated genes

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MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5RPS19, EPO, TEC

Publications for Transient Erythroblastopenia of Childhood

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Articles related to Transient Erythroblastopenia of Childhood:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. (24635829)
2014
2
Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. (22335327)
2012
3
Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. (21730806)
2011
4
Transient erythroblastopenia of childhood in siblings: case report and review of the literature. (17805047)
2007
5
Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. (15956889)
2005
6
Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. (11972099)
2002
7
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. (10804733)
2000
8
Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. (9633983)
1998
9
Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. (9674545)
1998
10
Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. (9260752)
1997
11
Breath-holding spells in a patient with transient erythroblastopenia of childhood. (9108866)
1997
12
Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. (9149751)
1997
13
Glycosylated haemoglobin and transient erythroblastopenia of childhood. (8551925)
1996
14
Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. (9025846)
1996
15
Transient erythroblastopenia of childhood in infants < 6 months of age. (8037344)
1994
16
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)
1994
17
Transient erythroblastopenia of childhood. Prospective study of fifty patients. (7978049)
1994
18
Transient erythroblastopenia of childhood presenting with echovirus 11 infection. (8518530)
1993
19
Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. (8214360)
1993
20
Parvovirus B19 and transient erythroblastopenia of childhood. (8518188)
1993
21
Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. (8435319)
1993
22
Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. (8338993)
1993
23
Human parvovirus infection and transient erythroblastopenia of childhood. (1327065)
1992
24
Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. (1536802)
1992
25
Immature lymphocytes in transient erythroblastopenia of childhood. (1907620)
1991
26
Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. (2140775)
1990
27
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. (2146287)
1990
28
AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. (2804355)
1989
29
Transient erythroblastopenia of childhood: implications for nurse practitioners. (2754596)
1989
30
Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. (2718996)
1989
31
Transient erythroblastopenia of childhood due to human parvovirus B19 infection. (2553096)
1989
32
Reduced neutrophil counts in children with transient erythroblastopenia of childhood. (2809908)
1989
33
Seasonal clustering of transient erythroblastopenia of childhood. (2829620)
1988
34
Transient erythroblastopenia of childhood. (18750483)
1988
35
Transient neurological disorder associated with transient erythroblastopenia of childhood. (3592128)
1987
36
Transient erythroblastopenia of childhood not associated with human parvovirus infection. (2869252)
1986
37
Transient erythroblastopenia of childhood presenting with papilledema. (3698450)
1986
38
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. (2982125)
1985
39
T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. (3871630)
1985
40
Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. (4013369)
1985
41
Transient erythroblastopenia of childhood. A review of 22 cases. (6593224)
1984
42
Transient erythroblastopenia of childhood: varied pathogenesis. (6846328)
1983
43
Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. (7293995)
1981
44
Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). (7254949)
1981
45
Transient erythroblastopenia of childhood. (7271473)
1981
46
Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. (7254979)
1981
47
Nursing care study: transient erythroblastopenia of childhood. (6907956)
1981
48
Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. (6968143)
1980
49
Immune suppression of erythropoiesis in transient erythroblastopenia of childhood. (465738)
1979
50
Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia. (131849)
1976

Variations for Transient Erythroblastopenia of Childhood

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Expression for genes affiliated with Transient Erythroblastopenia of Childhood

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Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.1EPO, TEC
2
Show member pathways
EPO Receptor Signaling36
EPO signaling pathway36
9.1EPO, TEC

Compounds for genes affiliated with Transient Erythroblastopenia of Childhood

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Sources:
43Novoseek, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1phosphatidylinositol439.1EPO, TEC
2inositol439.0EPO, TEC
3cyclosporin a43 28 5910.8EPO, TEC

GO Terms for genes affiliated with Transient Erythroblastopenia of Childhood

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Products for genes affiliated with Transient Erythroblastopenia of Childhood

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Sources for Transient Erythroblastopenia of Childhood

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet