Transient Erythroblastopenia of Childhood disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

OMIM:⁵² Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most... (227050) more...

MalaCards based summary: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to chondrosarcoma and myxoid chondrosarcoma, and has symptoms including transient erythroblastopenia An important gene associated with Transient Erythroblastopenia of Childhood is TEC (Tec Protein Tyrosine Kinase), and among its related pathways are Tyrosine Kinases / Adaptors and Development EPO-induced Jak-STAT pathway. Affiliated tissues include bone marrow, bone and neutrophil, and related mouse phenotype limbs/digits/tail.

Wikipedia:⁷¹ Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Related Diseases for Transient Erythroblastopenia of Childhood

Sources:
²⁰GeneAnalytics, ²¹GeneCards
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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

id	Related Disease	Score	Top Affiliating Genes
1	chondrosarcoma	10.1
2	myxoid chondrosarcoma	10.0
3	extranodal nasal nk/t cell lymphoma	9.9	EPO, KITLG
4	dic in newborn	9.9	EPO, KITLG
5	nephrogenic adenofibroma	9.9	EPO, KITLG
6	intestinal impaction	9.9	EPO, KITLG
7	erythrocytosis, somatic	9.8	EPO, KITLG
8	peroxisome biogenesis disorder 7a	9.8	EPO, KITLG
9	aplastic anemia	9.8
10	hemolytic anemia	9.8
11	hepatitis	9.8
12	metabolic acidosis	9.8
13	congenital hypoplastic anemia	9.8
14	papilledema	9.8
15	transient hypogammaglobulinemia	9.8
16	b cell deficiency	9.8
17	actinobacillosis	9.8	EPO, KITLG
18	neuronal ceroid-lipofuscinoses	9.7	EPO, RPS19
19	drug-induced hepatitis	9.7	EPO, KITLG, RPS19
20	hyperparathyroidism, neonatal	9.7	EPO, KITLG, RPS19
21	hiv-1	9.7
22	asthma	9.7
23	multiple myeloma	9.7
24	myotonic dystrophy 1	9.3	EGID-100124696, EPO, KITLG, RPS19, TEC

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:

Symptoms & Phenotypes for Transient Erythroblastopenia of Childhood

Sources:
⁴¹MGI, ⁵²OMIM, ⁶⁴The Human Phenotype Ontology
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Symptoms by clinical synopsis from OMIM:

227050

Clinical features from OMIM:

227050

Human phenotypes related to Transient Erythroblastopenia of Childhood:

⁶⁴

id	Description	HPO Frequency	HPO Source Accession
1	transient erythroblastopenia⁶⁴		HP:0005510

MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	8.5	EPO, KITLG, RPS19

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Sources:
⁴ClinicalTrials, ⁴⁶NDF-RT, ⁶⁸UMLS
See all MalaCards sources

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

³⁶

Bone marrow, Bone, Neutrophil, T cells

Publications for Transient Erythroblastopenia of Childhood

Sources:
⁵⁷PubMed
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Articles related to Transient Erythroblastopenia of Childhood:

(show top 50) (show all 53)

id	Title	Authors	Year
1	Deformation of erythroblasts in transient erythroblastopenia of childhood caused by HHV-6. (28092892)	Ogawa A.... Yanagisawa R.	2016
2	Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. (24635829)	van den Akker M.... Odame I.	2014
3	Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. (22335327)	Moritake H.... Nunoi H.	2012
4	Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. (21730806)	Schinasi D.A.... Shah M.	2011
5	Transient erythroblastopenia of childhood in siblings: case report and review of the literature. (17805047)	Shaw J.... Meeder R.	2007
6	Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. (15956889)	Prassouli A.... Dracou C.	2005
7	Familial transient erythroblastopenia of childhood is associated with the chromosome 19q13.2 region but not caused by mutations in coding sequences of the ribosomal protein S19 (RPS19) gene. (12358933)	Gustavsson P.... Dahl N.	2002
8	Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. (11972099)	Skeppner G.... Elinder G.	2002
9	Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. (10804733)	Itonaga N.... Momoi M.Y.	2000
10	Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. (9674545)	Farhi D.C.... Rosenthal N.S.	1998
11	Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. (9633983)	Chan G.C.... Wilimas J.	1998
12	Breath-holding spells in a patient with transient erythroblastopenia of childhood. (9108866)	Tam D.A.... Rash F.C.	1997
13	Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. (9149751)	Mupanomunda O.K.... Alter B.P.	1997
14	Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. (9260752)	Penchansky L.... Jordan J.A.	1997
15	Glycosylated haemoglobin and transient erythroblastopenia of childhood. (8551925)	Karsten J.... Odink R.J.	1996
16	Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. (9025846)	Rogers B.B.... Timmons C.F.	1996
17	Transient erythroblastopenia of childhood. Prospective study of fifty patients. (7978049)	Cherrick I.... Lanzkowsky P.	1994
18	Transient erythroblastopenia of childhood in infants < 6 months of age. (8037344)	Miller R.... Berman B.	1994
19	Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)	Chabali R.	1994
20	Transient erythroblastopenia of childhood presenting with echovirus 11 infection. (8518530)	Elian J.C.... Freycon F.	1993
21	Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. (8214360)	Tamary H.... Zaizov R.	1993
22	Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. (8435319)	Linderkamp O.... Ludwig A.	1993
23	Parvovirus B19 and transient erythroblastopenia of childhood. (8518188)	Nikkari S.... Wanne O.	1993
24	Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. (8338993)	Skeppner G.... Wranne L.	1993
25	Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. (1536802)	Nagai K.... Matsunaga Y.	1992
26	Human parvovirus infection and transient erythroblastopenia of childhood. (1327065)	Muir K.W.... Fitzsimons E.	1992
27	Immature lymphocytes in transient erythroblastopenia of childhood. (1907620)	Reid M.M.	1991
28	Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. (2140775)	Leuschner S.... Rister M.	1990
29	Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. (2146287)	Foot A.B.... Oakhill A.	1990
30	Transient erythroblastopenia of childhood due to human parvovirus B19 infection. (2553096)	Wodzinski M.A.... Lilleyman J.S.	1989
31	Reduced neutrophil counts in children with transient erythroblastopenia of childhood. (2809908)	Rogers Z.R.... Glader B.E.	1989
32	Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. (2718996)	Hays T.... Shafer F.	1989
33	AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. (2804355)	Paglia D.E.... Brockway R.A.	1989
34	Transient erythroblastopenia of childhood: implications for nurse practitioners. (2754596)	Brewin-Wilson D.M.	1989
35	Transient erythroblastopenia of childhood. (18750483)	Glader B.E.	1988
36	Seasonal clustering of transient erythroblastopenia of childhood. (2829620)	Bhambhani K.... Sarnaik S.A.	1988
37	Transient neurological disorder associated with transient erythroblastopenia of childhood. (3592128)	Michelson A.D.... Marshall P.C.	1987
38	Transient erythroblastopenia of childhood not associated with human parvovirus infection. (2869252)	Bhambhani K.... Merline J.	1986
39	Transient erythroblastopenia of childhood presenting with papilledema. (3698450)	Green N.S.... Chutorian A.	1986
40	Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. (2982125)	Beutler E.... Hartman G.	1985
41	Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. (4013369)	Ritchey A.K.... Hoffman R.	1985
42	T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. (3871630)	Hanada T.... Takita H.	1985
43	Transient erythroblastopenia of childhood. A review of 22 cases. (6593224)	Gerrits G.P.... Bakkeren J.A.	1984
44	Transient erythroblastopenia of childhood: varied pathogenesis. (6846328)	Freedman M.H.... Saunders E.F.	1983
45	Nursing care study: transient erythroblastopenia of childhood. (6907956)	Ross J.M.	1981
46	Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. (7293995)	Labotka R.J.... Honig G.R.	1981
47	Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). (7254949)	Link M.P.... Alter B.P.	1981
48	Transient erythroblastopenia of childhood. (7271473)	Corrigan J.J.	1981
49	Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. (7254979)	Dickerman J.D.	1981
50	Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. (6968143)	Inoue S.... Ito T.	1980

Genes related to Transient Erythroblastopenia of Childhood

Sources:
²¹GeneCards, ⁵⁰Novoseek, ⁵²OMIM
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Genes related to Transient Erythroblastopenia of Childhood (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	TEC	Tec Protein Tyrosine Kinase	58.75	Genetic linkage ⁵² GeneCards inferred via : Disorders (show sections)
2	EGID-100124696	Transient Erythroblastopenia Of Childhood	30.07	GeneCards inferred via : Disorders, Publications, Gene name (show sections)
3	RPS19	Ribosomal Protein S19	28.32	GeneCards inferred via : Disorders, Publications (show sections)
4	EPO	Erythropoietin	25.25	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	1552389
5	KITLG	KIT Ligand	25.22	Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders (show sections)	1282827

Variations for Transient Erythroblastopenia of Childhood

Expression for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁹R&D Systems, ⁶⁵Thomson Reuters
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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Tyrosine Kinases / Adaptors³	9.5	KITLG, TEC
2	Development EPO-induced Jak-STAT pathway⁶⁵ Show member pathways EPO signaling pathway⁴² EPO Receptor Signaling⁴²	9.2	EPO, TEC
3	Differentiation Pathway⁴²	9.1	EPO, KITLG
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁹	9.1	EPO, KITLG
5	Hematopoietic cell lineage³⁴	9.1	EPO, KITLG
6	Hematopoietic Stem Cell Differentiation⁴²	9.1	EPO, KITLG
7	Kit receptor signaling pathway⁴² Show member pathways Signaling events mediated by Stem cell factor receptor (c-Kit)⁴² IL-3 Signaling Pathway⁴²	8.7	EPO, KITLG, TEC

GO Terms for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
¹⁹Gene Ontology
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Biological processes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.8	KITLG, TEC
2	positive regulation of DNA replication	GO:0045740	9.7	EPO, KITLG
3	erythrocyte differentiation	GO:0030218	9.6	EPO, RPS19
4	positive regulation of Ras protein signal transduction	GO:0046579	9.1	EPO, KITLG