TEC
MCID: TRN030
MIFTS: 34

Transient Erythroblastopenia of Childhood (TEC) malady

Categories: Genetic diseases, Rare diseases, Immune diseases, Blood diseases

Aliases & Classifications for Transient Erythroblastopenia of Childhood

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Sources:
12diseasecard, 30ICD10, 31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Transient Erythroblastopenia of Childhood:

Name: Transient Erythroblastopenia of Childhood 52 48 54 12
Transient Acquired Pure Red Cell Aplasia 54 68
Erythroblastopenia, Transient 48 50
 
Familial Transient Erythroblastopenia of Childhood 48
Tec 48

Characteristics:

HPO:

64
transient erythroblastopenia of childhood:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 227050
Orphanet54 ORPHA98871
MESH via Orphanet40 C536980
ICD10 via Orphanet31 D60.1
UMLS via Orphanet69 C0238478
ICD1030 D60.1

Summaries for Transient Erythroblastopenia of Childhood

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OMIM:52 Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most... (227050) more...

MalaCards based summary: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to chondrosarcoma and myxoid chondrosarcoma, and has symptoms including transient erythroblastopenia An important gene associated with Transient Erythroblastopenia of Childhood is TEC (Tec Protein Tyrosine Kinase), and among its related pathways are Tyrosine Kinases / Adaptors and Development EPO-induced Jak-STAT pathway. Affiliated tissues include bone marrow, bone and neutrophil, and related mouse phenotype limbs/digits/tail.

Wikipedia:71 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Related Diseases for Transient Erythroblastopenia of Childhood

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Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to transient erythroblastopenia of childhood

Symptoms & Phenotypes for Transient Erythroblastopenia of Childhood

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Symptoms by clinical synopsis from OMIM:

227050

Clinical features from OMIM:

227050

Human phenotypes related to Transient Erythroblastopenia of Childhood:

 64
id Description HPO Frequency HPO Source Accession
1 transient erythroblastopenia64 HP:0005510

MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5EPO, KITLG, RPS19

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

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Anatomical Context for Transient Erythroblastopenia of Childhood

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MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

36
Bone marrow, Bone, Neutrophil, T cells

Publications for Transient Erythroblastopenia of Childhood

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Articles related to Transient Erythroblastopenia of Childhood:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Deformation of erythroblasts in transient erythroblastopenia of childhood caused by HHV-6. (28092892)
2016
2
Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. (24635829)
2014
3
Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. (22335327)
2012
4
Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. (21730806)
2011
5
Transient erythroblastopenia of childhood in siblings: case report and review of the literature. (17805047)
2007
6
Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. (15956889)
2005
7
Familial transient erythroblastopenia of childhood is associated with the chromosome 19q13.2 region but not caused by mutations in coding sequences of the ribosomal protein S19 (RPS19) gene. (12358933)
2002
8
Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. (11972099)
2002
9
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. (10804733)
2000
10
Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. (9674545)
1998
11
Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. (9633983)
1998
12
Breath-holding spells in a patient with transient erythroblastopenia of childhood. (9108866)
1997
13
Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. (9149751)
1997
14
Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. (9260752)
1997
15
Glycosylated haemoglobin and transient erythroblastopenia of childhood. (8551925)
1996
16
Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. (9025846)
1996
17
Transient erythroblastopenia of childhood. Prospective study of fifty patients. (7978049)
1994
18
Transient erythroblastopenia of childhood in infants < 6 months of age. (8037344)
1994
19
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)
1994
20
Transient erythroblastopenia of childhood presenting with echovirus 11 infection. (8518530)
1993
21
Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. (8214360)
1993
22
Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. (8435319)
1993
23
Parvovirus B19 and transient erythroblastopenia of childhood. (8518188)
1993
24
Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. (8338993)
1993
25
Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. (1536802)
1992
26
Human parvovirus infection and transient erythroblastopenia of childhood. (1327065)
1992
27
Immature lymphocytes in transient erythroblastopenia of childhood. (1907620)
1991
28
Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. (2140775)
1990
29
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. (2146287)
1990
30
Transient erythroblastopenia of childhood due to human parvovirus B19 infection. (2553096)
1989
31
Reduced neutrophil counts in children with transient erythroblastopenia of childhood. (2809908)
1989
32
Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. (2718996)
1989
33
AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. (2804355)
1989
34
Transient erythroblastopenia of childhood: implications for nurse practitioners. (2754596)
1989
35
Transient erythroblastopenia of childhood. (18750483)
1988
36
Seasonal clustering of transient erythroblastopenia of childhood. (2829620)
1988
37
Transient neurological disorder associated with transient erythroblastopenia of childhood. (3592128)
1987
38
Transient erythroblastopenia of childhood not associated with human parvovirus infection. (2869252)
1986
39
Transient erythroblastopenia of childhood presenting with papilledema. (3698450)
1986
40
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. (2982125)
1985
41
Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. (4013369)
1985
42
T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. (3871630)
1985
43
Transient erythroblastopenia of childhood. A review of 22 cases. (6593224)
1984
44
Transient erythroblastopenia of childhood: varied pathogenesis. (6846328)
1983
45
Nursing care study: transient erythroblastopenia of childhood. (6907956)
1981
46
Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. (7293995)
1981
47
Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). (7254949)
1981
48
Transient erythroblastopenia of childhood. (7271473)
1981
49
Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. (7254979)
1981
50
Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. (6968143)
1980

Variations for Transient Erythroblastopenia of Childhood

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Expression for genes affiliated with Transient Erythroblastopenia of Childhood

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Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

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GO Terms for genes affiliated with Transient Erythroblastopenia of Childhood

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Biological processes related to Transient Erythroblastopenia of Childhood according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.8KITLG, TEC
2positive regulation of DNA replicationGO:00457409.7EPO, KITLG
3erythrocyte differentiationGO:00302189.6EPO, RPS19
4positive regulation of Ras protein signal transductionGO:00465799.1EPO, KITLG

Sources for Transient Erythroblastopenia of Childhood

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet