Transient Erythroblastopenia of Childhood disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Transient Erythroblastopenia of Childhood

Sources:
⁴⁶OMIM, ⁶⁴Wikipedia, ³²MalaCards
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OMIM:⁴⁶ Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most... (227050) more...

MalaCards based summary: Transient Erythroblastopenia of Childhood, also known as familial transient erythroblastopenia of childhood, is related to aplastic anemia and chondrosarcoma, and has symptoms including autosomal recessive inheritanceand transient erythroblastopenia. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (tec protein tyrosine kinase), and among its related pathways are Kit Receptor Signaling Pathway and Development EPO induced Jak STAT pathway. The compounds phosphatidylinositol and inositol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and t cells, and related mouse phenotype hematopoietic system.

Wikipedia:⁶⁴ Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

Aliases & Classifications for Transient Erythroblastopenia of Childhood

Sources:
⁴²NIH Rare Diseases, ⁴⁶OMIM, ⁴⁸Orphanet, ⁶¹UMLS, ⁴⁴Novoseek, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
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Transient Erythroblastopenia of Childhood, Aliases & Descriptions:

Name: Transient Erythroblastopenia of Childhood ⁴² ⁴⁶ ⁴⁸ ⁶¹

Familial Transient Erythroblastopenia of Childhood ⁴² ⁶¹

Transient Acquired Pure Red Cell Aplasia ⁴⁸ ⁶¹

Erythroblastopenia, Transient ⁴² ⁴⁴

Decreased Erythroid Precursor Production ⁶¹

Tec ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases

ICD10: ²⁷ ²⁶

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Aplastic and other anaemias

Acquired pure red cell aplasia [erythroblastopenia]

Transient acquired pure red cell aplasia

Orphanet: ⁴⁸

Rare haematological diseases

External Ids:

OMIM⁴⁶ 227050

MESH via Orphanet³⁵ C536980

ICD10 via Orphanet²⁷ D60.1

UMLS via Orphanet⁶² C0238478

ICD10²⁶ D60.1

Related Diseases for Transient Erythroblastopenia of Childhood

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 24)

id	Related Disease	Score	Top Affiliating Genes
1	aplastic anemia	30.0	RPS19, EPO
2	chondrosarcoma	10.4
3	extraskeletal myxoid chondrosarcoma	10.3
4	myxoid chondrosarcoma	10.3
5	hemolytic anemia	10.3
6	hepatitis	10.3
7	metabolic acidosis	10.3
8	congenital hypoplastic anemia	10.3
9	papilledema	10.3
10	transient hypogammaglobulinemia	10.3
11	behcet's disease	10.3
12	b cell deficiency	10.2
13	asthma	10.0
14	multiple myeloma	10.0
15	neutropenia	10.0
16	autoimmune hemolytic anemia	10.0
17	allergic asthma	10.0
18	candidiasis	10.0
19	endometrial carcinoma	10.0
20	myeloma	10.0
21	endotheliitis	10.0
22	diamond-blackfan anemia	9.8	EPO, RPS19
23	deficiency anemia	9.8	EPO, RPS19
24	diamond-blackfan anemia 1	9.8	RPS19, EPO

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:

Symptoms for Transient Erythroblastopenia of Childhood

Sources:
⁴⁶OMIM, ⁵⁸The Human Phenotype Ontology
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Symptoms by clinical synopsis from OMIM:

227050

Clinical features from OMIM:

227050

HPO human phenotypes related to Transient Erythroblastopenia of Childhood:

id	Description	Frequency	HPO Source Accession
1	autosomal recessive inheritance		HP:0000007
2	transient erythroblastopenia		HP:0005510

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Transient Erythroblastopenia of Childhood

Search NIH Clinical Center for Transient Erythroblastopenia of Childhood

Genetic Tests for Transient Erythroblastopenia of Childhood

Anatomical Context for Transient Erythroblastopenia of Childhood

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³²MalaCards
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MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

³²

Bone marrow, Bone, T cells, Neutrophil

Animal Models for Transient Erythroblastopenia of Childhood or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	8.5	RPS19, EPO, TEC

Publications for Transient Erythroblastopenia of Childhood

Sources:
⁵¹PubMed
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Articles related to Transient Erythroblastopenia of Childhood:

(show top 50) (show all 52)

id	Title	Authors	Year
1	Transient erythroblastopenia of childhood is an underdiagnosed and self-limiting disease. (24635829)	van den Akker M.... Odame I.	2014
2	Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. (22335327)	Moritake H.... Nunoi H.	2012
3	Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. (21730806)	Schinasi D.A.... Shah M.	2011
4	Transient erythroblastopenia of childhood in siblings: case report and review of the literature. (17805047)	Shaw J.... Meeder R.	2007
5	Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. (15956889)	Prassouli A.... Dracou C.	2005
6	Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. (11972099)	Skeppner G.... Elinder G.	2002
7	Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. (10804733)	Itonaga N.... Momoi M.Y.	2000
8	Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. (9633983)	Chan G.C.... Wilimas J.	1998
9	Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. (9674545)	Farhi D.C.... Rosenthal N.S.	1998
10	Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. (9260752)	Penchansky L.... Jordan J.A.	1997
11	Breath-holding spells in a patient with transient erythroblastopenia of childhood. (9108866)	Tam D.A.... Rash F.C.	1997
12	Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. (9149751)	Mupanomunda O.K.... Alter B.P.	1997
13	Glycosylated haemoglobin and transient erythroblastopenia of childhood. (8551925)	Karsten J.... Odink R.J.	1996
14	Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. (9025846)	Rogers B.B.... Timmons C.F.	1996
15	Transient erythroblastopenia of childhood in infants < 6 months of age. (8037344)	Miller R.... Berman B.	1994
16	Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)	Chabali R.	1994
17	Transient erythroblastopenia of childhood presenting with echovirus 11 infection. (8518530)	Elian J.C.... Freycon F.	1993
18	Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. (8214360)	Tamary H.... Zaizov R.	1993
19	Parvovirus B19 and transient erythroblastopenia of childhood. (8518188)	Nikkari S.... Wanne O.	1993
20	Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. (8435319)	Linderkamp O.... Ludwig A.	1993
21	Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. (8338993)	Skeppner G.... Wranne L.	1993
22	Human parvovirus infection and transient erythroblastopenia of childhood. (1327065)	Muir K.W.... Fitzsimons E.	1992
23	Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. (1536802)	Nagai K.... Matsunaga Y.	1992
24	Immature lymphocytes in transient erythroblastopenia of childhood. (1907620)	Reid M.M.	1991
25	Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. (2140775)	Leuschner S.... Rister M.	1990
26	Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. (2146287)	Foot A.B.... Oakhill A.	1990
27	AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. (2804355)	Paglia D.E.... Brockway R.A.	1989
28	Transient erythroblastopenia of childhood: implications for nurse practitioners. (2754596)	Brewin-Wilson D.M.	1989
29	Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. (2718996)	Hays T.... Shafer F.	1989
30	Transient erythroblastopenia of childhood due to human parvovirus B19 infection. (2553096)	Wodzinski M.A.... Lilleyman J.S.	1989
31	Reduced neutrophil counts in children with transient erythroblastopenia of childhood. (2809908)	Rogers Z.R.... Glader B.E.	1989
32	Seasonal clustering of transient erythroblastopenia of childhood. (2829620)	Bhambhani K.... Sarnaik S.A.	1988
33	Transient erythroblastopenia of childhood. (18750483)	Glader B.E.	1988
34	Transient neurological disorder associated with transient erythroblastopenia of childhood. (3592128)	Michelson A.D.... Marshall P.C.	1987
35	Transient erythroblastopenia of childhood not associated with human parvovirus infection. (2869252)	Bhambhani K.... Merline J.	1986
36	Transient erythroblastopenia of childhood presenting with papilledema. (3698450)	Green N.S.... Chutorian A.	1986
37	Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. (2982125)	Beutler E.... Hartman G.	1985
38	T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. (3871630)	Hanada T.... Takita H.	1985
39	Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. (4013369)	Ritchey A.K.... Hoffman R.	1985
40	Transient erythroblastopenia of childhood. A review of 22 cases. (6593224)	Gerrits G.P.... Bakkeren J.A.	1984
41	Transient erythroblastopenia of childhood: varied pathogenesis. (6846328)	Freedman M.H.... Saunders E.F.	1983
42	Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. (7293995)	Labotka R.J.... Honig G.R.	1981
43	Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). (7254949)	Link M.P.... Alter B.P.	1981
44	Transient erythroblastopenia of childhood. (7271473)	Corrigan J.J.	1981
45	Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. (7254979)	Dickerman J.D.	1981
46	Nursing care study: transient erythroblastopenia of childhood. (6907956)	Ross J.M.	1981
47	Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. (6968143)	Inoue S.... Ito T.	1980
48	Immune suppression of erythropoiesis in transient erythroblastopenia of childhood. (465738)	Koenig H.M.... DIAMOND L.K.	1979
49	Idiopathic transient erythroblastopenia of childhood. (546244)	Al-Rashid R.A.	1979
50	Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia. (131849)	Wang W.C.... Mentzer W.C.	1976

Genes related to Transient Erythroblastopenia of Childhood

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁴⁶OMIM
See all sources

Genes related to Transient Erythroblastopenia of Childhood:

- Elite gene

id	Symbol	Description	Score	Implication
1	TEC	tec protein tyrosine kinase	20.00	Genetic linkage ⁴⁶
2	RPS19	ribosomal protein S19	17.61	GeneCards inferred via : Publications (show sections)
3	EPO	erythropoietin	12.61	GeneCards inferred via : Publications (show sections)
4	EGID-100124696	transient erythroblastopenia of childhood	8.05	GeneCards inferred via : Publications, Gene name (show sections)

Products for genes related to Transient Erythroblastopenia of Childhood disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	3	-	3	3
2	Novus Biologicals	3	3	3	-

Variations for Transient Erythroblastopenia of Childhood

Expression for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters
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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Kit Receptor Signaling Pathway³⁷ Show member pathways Signaling events mediated by Stem cell factor receptor (c-Kit)³⁷	9.1	EPO, TEC
2	Development EPO induced Jak STAT pathway⁵⁹ Show member pathways EPO Receptor Signaling³⁷ EPO signaling pathway³⁷	9.1	EPO, TEC