TEC
MCID: TRN030
MIFTS: 39

Transient Erythroblastopenia of Childhood (TEC) malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases categories

Summaries for Transient Erythroblastopenia of Childhood

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Transient erythroblastopenia of childhood (TEC) is a slowly developing anemia of early childhood... more...

MalaCards: Transient Erythroblastopenia of Childhood, also known as transient acquired pure red cell aplasia, is related to aplastic anemia and chondrosarcoma. An important gene associated with Transient Erythroblastopenia of Childhood is TEC (tec protein tyrosine kinase), and among its related pathways are Kit Receptor Signaling Pathway and Development EPO induced Jak STAT pathway. The compounds phosphatidylinositol and inositol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and t cells, and related mouse phenotype hematopoietic system.

Description from OMIM:48 227050

Aliases & Classifications for Transient Erythroblastopenia of Childhood

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44NIH Rare Diseases, 48OMIM, 50Orphanet, 63UMLS, 46Novoseek, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

transient erythroblastopenia of childhood 44 48 50 63
transient acquired pure red cell aplasia 50 63
erythroblastopenia, transient 44 46
familial transient erythroblastopenia of childhood 44
decreased erythroid precursor production 63
tec 44


External Ids:

OMIM48 227050
MESH via Orphanet37 C536980
ICD10 via Orphanet27 D60.1
SNOMED-CT via Orphanet60 234375006
UMLS via Orphanet64 C0238478
ICD1026 D60.1

Related Diseases for Transient Erythroblastopenia of Childhood

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18GeneCards, 19GeneDecks
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Diseases related to Transient Erythroblastopenia of Childhood via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 24)
idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia30.3RPS19, EPO
2chondrosarcoma10.3
3metabolic acidosis10.3
4congenital hypoplastic anemia10.3
5hemolytic anemia10.3
6hepatitis10.3
7papilledema10.3
8transient hypogammaglobulinemia10.3
9extraskeletal myxoid chondrosarcoma10.3
10behcet's disease10.3
11myxoid chondrosarcoma10.3
12b cell deficiency10.2
13allergic asthma10.0
14autoimmune hemolytic anemia10.0
15asthma10.0
16candidiasis10.0
17endometrial carcinoma10.0
18multiple myeloma10.0
19myeloma10.0
20neutropenia10.0
21endotheliitis10.0
22diamond-blackfan anemia10.0RPS19, EPO
23deficiency anemia10.0RPS19, EPO
24diamond-blackfan anemia 19.9EPO, RPS19

Graphical network of the top 20 diseases related to Transient Erythroblastopenia of Childhood:



Diseases related to transient erythroblastopenia of childhood

Symptoms for Transient Erythroblastopenia of Childhood

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48OMIM
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Symptoms by clinical synopsis from OMIM:

227050

Clinical features from OMIM:

227050

Drugs & Therapeutics for Transient Erythroblastopenia of Childhood

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Transient Erythroblastopenia of Childhood

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Anatomical Context for Transient Erythroblastopenia of Childhood

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34MalaCards
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MalaCards organs/tissues related to Transient Erythroblastopenia of Childhood:

34
Bone marrow, Bone, T cells

Animal Models for Transient Erythroblastopenia of Childhood or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Transient Erythroblastopenia of Childhood:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5RPS19, EPO, TEC

Publications for Transient Erythroblastopenia of Childhood

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53PubMed
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Articles related to Transient Erythroblastopenia of Childhood:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Concomitant transient erythroblastopenia of childhood with neonatal hepatitis. (22335327)
2012
2
Ectopic atrial tachycardia in an infant with transient erythroblastopenia of childhood. (21730806)
2011
3
Transient erythroblastopenia of childhood in siblings: case report and review of the literature. (17805047)
2007
4
Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. (15956889)
2005
5
Transient erythroblastopenia of childhood: prospective study of 10 patients with special reference to viral infections. (11972099)
2002
6
Case of transient erythroblastopenia of childhood with transient hypogammaglobulinemia. (10804733)
2000
7
Transient erythroblastopenia of childhood associated with transient neurologic deficit: report of a case and review of the literature. (9633983)
1998
8
Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood. (9674545)
1998
9
Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B. (9260752)
1997
10
Breath-holding spells in a patient with transient erythroblastopenia of childhood. (9108866)
1997
11
Transient erythroblastopenia of childhood (TEC) presenting as leukoerythroblastic anemia. (9149751)
1997
12
Glycosylated haemoglobin and transient erythroblastopenia of childhood. (8551925)
1996
13
Polymerase chain reaction amplification of archival material for parvovirus B19 in children with transient erythroblastopenia of childhood. (9025846)
1996
14
Transient erythroblastopenia of childhood in infants < 6 months of age. (8037344)
1994
15
Transient erythroblastopenia of childhood presenting with shock and metabolic acidosis. (7845854)
1994
16
Transient erythroblastopenia of childhood. Prospective study of fifty patients. (7978049)
1994
17
Transient erythroblastopenia of childhood presenting with echovirus 11 infection. (8518530)
1993
18
Transient erythroblastopenia of childhood. Evidence for cell-mediated suppression of erythropoiesis. (8214360)
1993
19
Parvovirus B19 and transient erythroblastopenia of childhood. (8518188)
1993
20
Age dependency of red blood cell deformability and density: studies in transient erythroblastopenia of childhood. (8435319)
1993
21
Transient erythroblastopenia of childhood in Sweden: incidence and findings at the time of diagnosis. (8338993)
1993
22
Human parvovirus infection and transient erythroblastopenia of childhood. (1327065)
1992
23
Transient erythroblastopenia of childhood with megakaryocytopenia associated with human parvovirus B19 infection. (1536802)
1992
24
Immature lymphocytes in transient erythroblastopenia of childhood. (1907620)
1991
25
Increase of CALLA-positive stimulated lymphoid cells in transient erythroblastopenia of childhood. (2140775)
1990
26
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow. (2146287)
1990
27
AMP deaminase as a cell-age marker in transient erythroblastopenia of childhood and its role in the adenylate economy of erythrocytes. (2804355)
1989
28
Transient erythroblastopenia of childhood: implications for nurse practitioners. (2754596)
1989
29
Transient erythroblastopenia of childhood. A review of 26 cases and reassessment of indications for bone marrow aspiration. (2718996)
1989
30
Transient erythroblastopenia of childhood due to human parvovirus B19 infection. (2553096)
1989
31
Reduced neutrophil counts in children with transient erythroblastopenia of childhood. (2809908)
1989
32
Seasonal clustering of transient erythroblastopenia of childhood. (2829620)
1988
33
Transient erythroblastopenia of childhood. (18750483)
1988
34
Transient neurological disorder associated with transient erythroblastopenia of childhood. (3592128)
1987
35
Transient erythroblastopenia of childhood not associated with human parvovirus infection. (2869252)
1986
36
Transient erythroblastopenia of childhood presenting with papilledema. (3698450)
1986
37
Age-related red cell enzymes in children with transient erythroblastopenia of childhood and with hemolytic anemia. (2982125)
1985
38
T-cell mediated inhibition of erythropoiesis in transient erythroblastopenia of childhood. (3871630)
1985
39
Variable in vitro erythropoiesis in patients with transient erythroblastopenia of childhood. (4013369)
1985
40
Transient erythroblastopenia of childhood. A review of 22 cases. (6593224)
1984
41
Transient erythroblastopenia of childhood: varied pathogenesis. (6846328)
1983
42
Transient erythroblastopenia of childhood. Review of 17 cases, including a pair of identical twins. (7293995)
1981
43
Fetal-like erythropoiesis during recovery from transient erythroblastopenia of childhood (TEC). (7254949)
1981
44
Transient erythroblastopenia of childhood. (7271473)
1981
45
Transient erythroblastopenia of childhood presenting with reticulocytosis and erythroid hyperplasia in the bone marrow. (7254979)
1981
46
Nursing care study: transient erythroblastopenia of childhood. (6907956)
1981
47
Absence of inhibitory cells from patients with aplastic anemia or transient erythroblastopenia of childhood on the in vitro growth of erythroid colonies. (6968143)
1980
48
Immune suppression of erythropoiesis in transient erythroblastopenia of childhood. (465738)
1979
49
Idiopathic transient erythroblastopenia of childhood. (546244)
1979
50
Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia. (131849)
1976

Variations for Transient Erythroblastopenia of Childhood

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Expression for genes affiliated with Transient Erythroblastopenia of Childhood

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Erythroblastopenia of Childhood

Search GEO for disease gene expression data for Transient Erythroblastopenia of Childhood.

Pathways for genes affiliated with Transient Erythroblastopenia of Childhood

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
9.1EPO, TEC
2
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.1EPO, TEC

Compounds for genes affiliated with Transient Erythroblastopenia of Childhood

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46Novoseek, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Transient Erythroblastopenia of Childhood according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1phosphatidylinositol469.1EPO, TEC
2inositol469.0EPO, TEC
3cyclosporin a46 30 6210.8EPO, TEC

GO Terms for genes affiliated with Transient Erythroblastopenia of Childhood

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Products for genes affiliated with Transient Erythroblastopenia of Childhood

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Transient Erythroblastopenia of Childhood

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet