TGA
MCID: TRN012
MIFTS: 40

Transient Global Amnesia (TGA) malady

Neuronal category

Summaries for Transient Global Amnesia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Transient global amnesia (tga) is a condition characterized by sudden onset of memory loss and confusion. affected individuals are often disoriented in regard to time and place but usually remember their identity and can recognize family members. tga typically lasts for hours, although its duration may range from minutes to days. individuals usually have only one episode of tga during their life, although the condition reoccurs in about 5-25 percent of people. affected individuals do not experience symptoms after the episode of amnesia has resolved. last updated: 6/2/2009

MalaCards: Transient Global Amnesia, also known as amnesia, transient global, is related to retrograde amnesia and stroke, ischemic. An important gene associated with Transient Global Amnesia is CRLF1 (cytokine receptor-like factor 1). The compounds cyclothiazide and chlorpromazine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart.

Disease Ontology:8 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia:64 Transient global amnesia (TGA) is a syndrome in clinical neurology whose key defining characteristic is... more...

Aliases & Classifications for Transient Global Amnesia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

transient global amnesia 8 43
amnesia, transient global 61
tga 43


External Ids:

Disease Ontology8 DOID:13027
NCIt40 C85198
ICD9CM27 437.7
MeSH35 D020236
ICD1025 G45.4

Related Diseases for Transient Global Amnesia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1retrograde amnesia10.5
2stroke, ischemic10.4
3acute myocardial infarction10.4
4aphasia10.4
5thrombocytopenia10.4
6transient cerebral ischemia10.4
7primary progressive aphasia10.4
8heparin-induced thrombocytopenia10.4
9herpes simplex encephalitis10.4
10head injury10.4
11memory impairment10.4
12transposition of the great arteries, dextro-looped 210.3
13transposition of the great arteries, dextro-looped 110.3
14transposition of great arteries, dextro-looped 310.3
15sneddon syndrome10.2
16antiphospholipid syndrome10.2
17patent foramen ovale10.2
18temporal lobe epilepsy10.2
19hyperhomocysteinemia10.2
20dissecting aortic aneurysm10.2
21viral encephalitis10.2
22cortical blindness10.2
23anterograde amnesia10.2
24carotid artery occlusion10.2
25obstructive hydrocephalus10.2
26adenoma10.2
27aortic aneurysm10.2
28spasmodic dysphonia10.2
29amaurosis fugax10.2
30basilar migraine10.2
31neurosyphilis10.2
32whiplash10.2
33hemorrhage, intracerebral10.2
34blindness10.2
35balint syndrome10.2
36congenitally corrected transposition of the great arteries10.2
37transposition of the great arteries10.2
38situs inversus10.1
39thalassemia10.1
40hemophilia10.1
41labyrinthitis10.0CRLF1
42sjogren's syndrome10.0APOH
43breast cancer10.0KLF6, FUT3
44pulmonary embolism10.0APOH
45ischemic optic neuropathy10.0PDE5A
46leukemia10.0CRLF1
47mixed connective tissue disease10.0APOH, HNRNPC
48rheumatic disease10.0HNRNPC, APOH
49vascular disease10.0APOH, CA1
50atherosclerosis10.0APOH, PDE5A

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to transient global amnesia

Clinical Features for Transient Global Amnesia

Drugs & Therapeutics for Transient Global Amnesia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

Sources:
33MalaCards
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MalaCards organs/tissues related to Transient Global Amnesia:

33
Brain, Cortex, Heart, B cells, Prefrontal cortex, Cingulate cortex, Temporal lobe, Thalamus, Caudate nucleus, Pituitary

Animal Models for Transient Global Amnesia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Transient Global Amnesia

Sources:
51PubMed
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Articles related to Transient Global Amnesia:

(show top 50)    (show all 479)
idTitleAuthorsYear
1
Lesion detectability on diffusion-weighted imaging in transient global amnesia: the influence of imaging timing and magnetic field strength. (21603902)
2012
2
Transient global amnesia as a revealing sign of giant transtentorial meningioma: case report and review of the literature. (21629022)
2011
3
Transient global amnesia: a brief review and update. (21894575)
2011
4
Transient global amnesia during a professional cello concert. (21737282)
2011
5
Bilateral Hippocampal DWI Lesions in Transient Global Amnesia. A Case Report. (24148590)
2010
6
Transient global amnesia: functional anatomy and clinical implications. (20129169)
2010
7
Transient global amnesia - not so rare after all. (19452291)
2009
8
A Tc-99m SPECT study of regional cerebral blood flow in patients with transient global amnesia. (19073268)
2009
9
Transient global amnesia following intravitreal injection of bevacizumab. (18537925)
2009
10
Transient global amnesia as a manifestation of acute myocardial infarction: a case of missed sudden cardiac death? (18639945)
2009
11
Transient global amnesia after dobutamine--atropine stress echocardiography. (17698416)
2008
12
Global cerebral hypoperfusion in a patient with transient global amnesia. (18520548)
2008
13
Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. (17522744)
2007
14
Transient global amnesia caused by painless aortic dissection. (17183052)
2007
15
Recurrency in transient global amnesia: a retrospective study. (16930365)
2006
16
Transient global amnesia triggered by the intracarotid amobarbital procedure. (15710318)
2005
17
Early Diagnosis and Treatment of Dementia Presenting as Transient Global Amnesia in a 76-Year-Old Man. (15614313)
2004
18
Transient global amnesia in a young adult with cyanotic heart disease. (14643397)
2003
19
Conducting without memory - a case report on transient global amnesia. (12453094)
2002
20
Episodic memory in transient global amnesia. (10071089)
1999
21
Transient global amnesia: a retrospective study of 25 patients. (10222601)
1999
22
Transient global amnesia and migraine. A case control study. (9693225)
1998
23
Cerebral perfusion during transient global amnesia: findings with HMPAO SPECT. (9443755)
1998
24
Emotional arousal and phobia in transient global amnesia. (9236576)
1997
25
Transient global amnesia: implicit/explicit memory dissociation and PET assessment of brain perfusion and oxygen metabolism in the acute stage. (9328254)
1997
26
Global transient amnesia and subclavian steal syndrome. (8667913)
1996
27
Recovery of high speed memory scanning after transient global amnesia: a case report. (9014229)
1996
28
Acute confusional migraine: variant of transient global amnesia. (7779209)
1995
29
Neurology quiz. Transient global amnesia. (8037634)
1994
30
Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. (8229038)
1993
31
Prognosis of transient global amnesia: a long-term follow-up study. (1563456)
1992
32
Bitemporal hypoperfusion in transient global amnesia: 99m-Tc-HM-PAO SPECT and neuropsychological findings during and after an attack. (2341849)
1990
33
Transient global amnesia following ingestion of chloroquine. (2266380)
1990
34
Transient global amnesia and Raynaud's phenomenon in scleroderma. (2220314)
1990
35
EEG features in transient global amnesia. (2752590)
1989
36
Platelet aggregation in transient global amnesia. (2737863)
1989
37
Extracranial carotid artery in patients with transient global amnesia: evaluation by real-time B-mode ultrasonography with duplex Doppler flow. (2957822)
1987
38
Transient global amnesia and migraine in twin sisters. (3612162)
1987
39
Transient global amnesia: clinical characteristics and prognosis. (3574671)
1987
40
Transient global amnesia associated with hydrocephalus. Report of two cases. (3430189)
1987
41
Memory performances before and after transient global amnesia. (3603612)
1987
42
Transient global amnesia and epilepsy. Electroencephalographic distinction. (3579680)
1987
43
Transient global amnesia triggered by mild head trauma. (3955333)
1986
44
Transient global amnesia and the amnestic syndrome. (3784695)
1986
45
Transient global amnesia--familial incidence. (7175534)
1982
46
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979
47
Sexual intercourse and transient global amnesia. (423930)
1979
48
Transient global amnesia due to a dominant hemisphere tumor. (857785)
1977
49
Transient global amnesia: report of two cases with definite etiologies. (5030973)
1972
50
Transient global amnesia following spinal anesthesia. (5033782)
1972

Genetic Variations for Transient Global Amnesia

Expression for genes affiliated with Transient Global Amnesia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for genes affiliated with Transient Global Amnesia

Compounds for genes affiliated with Transient Global Amnesia

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Transient Global Amnesia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cyclothiazide29 45 1111.7BDNF, CA1
2chlorpromazine45 29 50 1112.4BDNF, APOH
3cocaine45 1110.1RABEP2, APOH, BDNF
4gold458.9APOH, PDE5A, BDNF
5indomethacin45 60 29 1111.7PDE5A, CA1, BDNF
6norepinephrine45 11 2410.7PDE5A, CA1, BDNF
7dopamine45 29 11 2411.5RABEP2, PDE5A, BDNF
8arginine458.4HNRNPC, CA1, PDE5A, APOH
9hydrogen45 249.4PDE5A, CA1, BDNF
10zinc45 249.2APOH, PDE5A, CA1, BDNF, KLF6
11estrogen458.0KLF6, BDNF, PDE5A, APOH, RABEP2

GO Terms for genes affiliated with Transient Global Amnesia

Sources:
16Gene Ontology
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Biological processes related to Transient Global Amnesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ureteric bud developmentGO:0016579.6CRLF1, BDNF

Products for genes affiliated with Transient Global Amnesia

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Sources for Transient Global Amnesia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet