MCID: TRN012
MIFTS: 39

Transient Global Amnesia malady

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Transient Global Amnesia

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Aliases & Descriptions for Transient Global Amnesia:

Name: Transient Global Amnesia 11 48 13
Amnesia, Transient Global 39 68
 
Tga 48

Classifications:



External Ids:

Disease Ontology11 DOID:13027
ICD1030 G45.4
ICD9CM32 437.7
MeSH39 D020236
NCIt45 C85198

Summaries for Transient Global Amnesia

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NIH Rare Diseases:48 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own. Last updated: 10/31/2016

MalaCards based summary: Transient Global Amnesia, also known as amnesia, transient global, is related to transposition of the great arteries, dextro-looped 1 and congenitally corrected transposition of the great arteries, and has symptoms including amaurosis fugax An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways are FOXM1 transcription factor network and cAMP signaling pathway. Affiliated tissues include temporal lobe, brain and heart.

Disease Ontology:11 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia:71 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

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Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1transposition of the great arteries, dextro-looped 111.6
2congenitally corrected transposition of the great arteries11.3
3transposition of the great arteries11.1
4transposition of the great arteries, dextro-looped 211.1
5transposition of great arteries, dextro-looped 311.1
6conotruncal heart malformations10.8
7congenitally uncorrected transposition of the great arteries with cardiac malformation10.8
8congenitally uncorrected transposition of the great arteries with coarctation10.8
9cerebritis10.5
10embryoma10.4ALDH7A1, PDE5A
11congenital epulis10.2BDNF, KANTR
12color agnosia10.2EP300, KANTR
13munchausen by proxy10.2ALDH7A1, PDE5A
14cerebral degeneration10.2CRLF1, KANTR
15ischemia10.2
16sick sinus syndrome10.2EP300, PDE5A
17benign familial infantile epilepsy10.2BDNF, KANTR
18purulent labyrinthitis10.2CRLF1, KANTR
19olfactory neuroblastoma10.2CRLF1, KANTR
20hepatitis c10.2ALDH7A1, PDE5A
21subclavian artery aneurysm10.1CRLF1, KANTR
22peritoneal benign neoplasm10.1CRLF1, KANTR
23epilepsy10.1
24congenital hypoplastic anemia10.1KANTR, PSEN1
25diffuse alopecia areata10.1KANTR, PSEN1
26vaginal tubular adenoma10.1BDNF, EP300, PSEN1
27bile duct cystadenoma10.0KANTR, PSEN1
28retrograde amnesia10.0
29neuronitis10.0
30encephalitis10.0
31kidney osteogenic sarcoma10.0CA1, FOS
32elephantiasis10.0EP300, PSEN1
33myocardial infarction9.9
34acute myocardial infarction9.9
35hydrocephalus9.9
36thrombocytopenia9.9
37aphasia9.9
38herpes simplex9.9
39hyperhomocysteinemia9.9
40heparin-induced thrombocytopenia9.9
41head injury9.9
42intussusception9.9BDNF, CRLF1
43acrofrontofacionasal dysostosis9.9KANTR, PSEN1
44angiomyolipoma9.9BDNF, KANTR, PSEN1
45chronic intestinal vascular insufficiency9.9BDNF, KANTR, PSEN1
46nasal cavity inverting papilloma9.9EP300, PSEN1
47apraxia9.8EP300, KANTR, PSEN1
48thalassemia9.8
49ventricular septal defect9.8
50hemophilia9.8

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, EssentialTransient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to transient global amnesia

Symptoms & Phenotypes for Transient Global Amnesia

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UMLS symptoms related to Transient Global Amnesia:


amaurosis fugax

Drugs & Therapeutics for Transient Global Amnesia

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Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Midazolamapproved, illicitPhase 4, Phase 168459467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
 
Dormicum
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
2
Propofolapproved, investigational, vet_approvedPhase 4, Phase 110282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
3Pharmaceutical SolutionsPhase 4, Phase 17793
4Neurotransmitter AgentsPhase 4, Phase 117734
5Adjuvants, AnesthesiaPhase 4, Phase 11588
6Anesthetics, GeneralPhase 4, Phase 12787
7Tranquilizing AgentsPhase 4, Phase 14164
8AnestheticsPhase 4, Phase 19001
9Psychotropic DrugsPhase 4, Phase 16279
10Anti-Anxiety AgentsPhase 4, Phase 11816
11Hypnotics and SedativesPhase 4, Phase 12485
12Central Nervous System DepressantsPhase 4, Phase 112806
13Anesthetics, IntravenousPhase 4, Phase 12406
14GABA AgentsPhase 4, Phase 11622
15GABA ModulatorsPhase 4, Phase 1864
16
Dexmedetomidineapproved, vet_approvedPhase 154076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
17
Thiopentalapproved, vet_approvedPhase 13576-75-53000715
Synonyms:
()Thiopental solution
(+-)-Thiopental
(+/-)-THIOPENTAL
(+/-)Thiopental solution
2-Thio-5-ethyl-5-sec-pentylbarbituric acid
4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI)
5-24-09-00172 (Beilstein Handbook Reference)
5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione
5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
59709-53-4
76-75-5
AC-16029
AC1MHDBY
AC1Q2UJN
BRD-A72603112-236-02-4
BRN 0209361
BSPBio_003301
Bitaryl
C07521
C11H18N2O2S
CHEBI:102166
CHEMBL441
CID3000715
DB00599
DivK1c_000993
EINECS 200-984-3
I14-14129
IDI1_000993
Intraval
KBio1_000993
KBio2_002272
KBio2_004840
 
KBio2_007408
KBio3_002803
KBioGR_001010
KBioSS_002273
LS-24395
NCGC00159524-01
NINDS_000993
Omexolon
Penthiobarbital
Pentothal
Pentothiobarbital
SPBio_002215
Sodium Pentothal
Spectrum2_001998
Spectrum3_001781
Spectrum4_000575
Spectrum5_001692
Spectrum_001786
T1019_SIGMA
T1022_FLUKA
T1022_SIGMA
Thiomebumal
Thiomebumalum
Thionembutal
Thiopental
Thiopental [BAN]
Thiopentobarbital
Thiopentobarbitone
Thiopentobarbituric acid
Thiopentone
Thiothal
Tiopentale
Tiopentale [Italian]
Trapanal
UNII-JI8Z5M7NA3
thiopental
18AnticonvulsantsPhase 12620
19Peripheral Nervous System AgentsPhase 122776
20Analgesics, Non-NarcoticPhase 16260
21Adrenergic AgonistsPhase 12877
22Adrenergic AgentsPhase 15140
23Adrenergic alpha-2 Receptor AgonistsPhase 1911
24Adrenergic alpha-AgonistsPhase 11625
25AnalgesicsPhase 111287

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative MedicationCompletedNCT01976845Phase 4
2Effect of Affective Content on Drug Induced Amnesia of Episodic MemoryCompletedNCT00142493Phase 1
3Pilot Study of Spinal Manipulation for Chronic Neck PainTerminatedNCT00030004Phase 1
4Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted ProstatectomyCompletedNCT01905488
5Propofol's Hypnotic and Memory EffectsCompletedNCT00576615
6Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute PhaseRecruitingNCT02010853
7Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global AmnesiaRecruitingNCT02796287
8Neuropsycholgy and Neuroimaging in Transient Global AmnesiaTerminatedNCT02562560

Search NIH Clinical Center for Transient Global Amnesia


Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

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Anatomical Context for Transient Global Amnesia

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MalaCards organs/tissues related to Transient Global Amnesia:

36
Temporal lobe, Brain, Heart, Cortex, Testes, Caudate nucleus, Pituitary

Publications for Transient Global Amnesia

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Articles related to Transient Global Amnesia:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
A case of thalamo-mesencephalon infarct presenting as transient global amnesia: do we overlook the diagnosis? (28083760)
2017
2
A Case of Transient Global Amnesia with Small Left Putamen Infarction. (27863873)
2017
3
Recurrent transient global amnesia as presenting symptoms of CADASIL. (27830070)
2016
4
Transient global amnesia: Only in already disrupted neuronal integrity of memory network? (27538630)
2016
5
Transient Global Amnesia following Neural and Cardiac Angiography May Be Related to Ischemia. (27419129)
2016
6
Implicit Learning in Transient Global Amnesia and the Role of Stress. (27909401)
2016
7
Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. (27741293)
2016
8
Transient Global Amnesia: Emergency Department Evaluation And Management. (27416582)
2016
9
A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions. (27354927)
2016
10
Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery. (27535207)
2016
11
Posterior hippocampal stroke presenting with transient global amnesia. (28004602)
2016
12
Transient Global Amnesia After Cerebral Angiography With Iomeprol: A Case Report. (27175660)
2016
13
Seasonal Changes in the Incidence of Transient Global Amnesia. (27095523)
2016
14
Transient epileptic amnesia secondary to hippocampal dysplasia mimicking transient global amnesia. (27821268)
2016
15
Transient global amnesia revealing multiple sclerosis. (26830923)
2016
16
Hyperhomocysteinemia Association With Transient Global Amnesia: A Rare Case Report. (26417562)
2015
17
Teaching NeuroImages: Hippocampal foci of restricted diffusion in transient global amnesia. (26574541)
2015
18
Transient global amnesia like syndrome associated with acute infarction of the corpus callosum: a case report. (26643084)
2015
19
Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption. (26690067)
2015
20
Familial transient global amnesia. (25939944)
2015
21
Transient memory impairment and transient global amnesia induced by photodynamic therapy. (26122551)
2015
22
Transient global amnesia with a hippocampal lesion followed by transient epileptic amnesia. (26362391)
2015
23
Value of dynamic susceptibility contrast perfusion MRI in the acute phase of transient global amnesia. (25803440)
2015
24
Transient Global Amnesia as a Presenting Manifestation of Cerebral Venous Thrombosis. (26222971)
2015
25
Transient global amnesia and brain tumour: chance concurrence or aetiological association? Case report and systematic literature review. (25802501)
2015
26
Voxel seed coherent source analysis on transient global amnesia patients. (26736343)
2015
27
In reply--Familial Transient Global Amnesia. (25939946)
2015
28
CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients. (26045576)
2015
29
Transient Global Amnesia as the First Clinical Symptom for Malignant B-Cell Lymphoma with Central Nervous System Involvement. (26236514)
2015
30
The Still Enigmatic Syndrome of Transient Global Amnesia: Interactions Between Neurological and Psychopathological Factors. (25868986)
2015
31
Transient global amnesia. (26646345)
2015
32
Comment on " Transient memory impairment and transient global amnesia induced by Photodynamic Therapy". (26264886)
2015
33
'What is happening?': a case of transient global amnesia. (26646338)
2015
34
Hippocampal modifications in transient global amnesia. (25769554)
2015
35
Transient Global Amnesia with Reversible White Matter Lesions: A Variant of Posterior Reversible Encephalopathy Syndrome? (26697246)
2015
36
Stronger pharmacological cortisol suppression and anticipatory cortisol stress response in transient global amnesia. (25805980)
2015
37
Influence of depressive symptoms on memory inA transient global amnesia. (26179568)
2015
38
Obstruction of Venous Drainage Linked to Transient Global Amnesia. (26173146)
2015
39
A rare case of aortic dissection presenting as pure transient global amnesia. (26659651)
2015
40
Transient global amnesia with intracranial vertebral artery dissection and hippocampal CA1 lesion. (26238898)
2015
41
Of hearts and minds: A case of simultaneous transient global amnesia and regional left ventricular dysfunction. (26151711)
2015
42
Pre-existing structural abnormalities of the limbic system in transient global amnesia. (25818164)
2015
43
Transient Global Amnesia Triggered by Migraine in a French Tertiary-Care Center: An 11-Year Retrospective Analysis. (25877480)
2015
44
Transient global amnesia. (25659242)
2015
45
Transient global amnesia and broken heart syndrome: two faces of one pathology. (25822581)
2015
46
Thalamic Amnesia Mimicking Transient Global Amnesia. (26075467)
2015
47
Transient global amnesia after stellate ganglion block. (25686564)
2015
48
The structural connectivity of the recurrent transient global amnesia. (26467990)
2015
49
Transient global amnesia and Takotsubo syndrome: would cerebral blood flow brain scan be of any help? (25957759)
2015
50
Is a cancer diagnosis associated with subsequent risk of transient global amnesia? (25849383)
2015

Variations for Transient Global Amnesia

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Expression for genes affiliated with Transient Global Amnesia

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Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for genes affiliated with Transient Global Amnesia

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GO Terms for genes affiliated with Transient Global Amnesia

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Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.3BDNF, CRLF1, PSEN1

Sources for Transient Global Amnesia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet