MCID: TRN012
MIFTS: 40

Transient Global Amnesia

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Transient Global Amnesia

MalaCards integrated aliases for Transient Global Amnesia:

Name: Transient Global Amnesia 12 72 49 14
Amnesia, Transient Global 72 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD10 32 G45.4
ICD9CM 34 437.7
MeSH 41 D020236
NCIt 46 C85198
UMLS 69 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 49 Transient global amnesia (TGA) is a condition characterized by sudden onset of memory loss and confusion. During an episode of TGA, a person is not able to make new memories. The person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. TGA typically lasts for several hours, but can last up to ten hours. Since no memories are made during a TGA episode, the person will never remember what happened during this period, but all other memory is usually intact. Most people have only one episode of TGA during their lifetime. The underlying cause of TGA is unclear. There is no specific treatment for TGA as it usually resolves on its own. Last updated: 10/31/2016

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to migraine with or without aura 1 and cerebritis. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are TGF-beta Signaling Pathway (WikiPathways) and Spinal Cord Injury. Affiliated tissues include temporal lobe, brain and heart, and related phenotype is hematopoietic system.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 72 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.3 FOS KANTR PDE5A
2 cerebritis 10.6
3 ischemia 10.3
4 vasculogenic impotence 10.3 ALDH7A1 PDE5A
5 prosopagnosia 10.2 EP300 PSEN1
6 meningioma, familial 10.2
7 epilepsy 10.2
8 neuronitis 10.1
9 alveolar periostitis 10.1 KANTR MBL2
10 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.1
11 thrombosis 10.1
12 retrograde amnesia 10.1
13 encephalitis 10.1
14 alexia 10.1 KANTR PSEN1
15 glossopharyngeal neuralgia 10.0 CRLF1 KANTR
16 aganglionosis, total intestinal 10.0
17 stroke, ischemic 10.0
18 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.0
19 myocardial infarction 10.0
20 acute myocardial infarction 10.0
21 hydrocephalus 10.0
22 thrombocytopenia 10.0
23 aphasia 10.0
24 herpes simplex 10.0
25 heparin-induced thrombocytopenia 10.0
26 head injury 10.0
27 amnestic disorder 9.8 BDNF FOS PSEN1
28 central nervous system disease 9.8 BDNF PRNP PSEN1
29 apnea, obstructive sleep 9.8
30 cardiac arrhythmia 9.8
31 cardiac conduction defect 9.8
32 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.8
33 multiple sclerosis 9.8
34 sneddon syndrome 9.8
35 thrombophilia due to thrombin defect 9.8
36 aging 9.8
37 neuronal intranuclear inclusion disease 9.8
38 arteriovenous fistula 9.8
39 b-cell lymphomas 9.8
40 diabetes mellitus 9.8
41 temporal lobe epilepsy 9.8
42 segmental dystonia 9.8
43 sleep apnea 9.8
44 lymphoma 9.8
45 heart disease 9.8
46 cortical blindness 9.8
47 arachnoiditis 9.8
48 parametritis 9.8
49 dementia 9.8
50 patent foramen ovale 9.8

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

MGI Mouse Phenotypes related to Transient Global Amnesia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 CRLF1 EP300 FOS KLF6 MBL2 PRNP

Drugs & Therapeutics for Transient Global Amnesia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase Completed NCT02010853
2 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
3 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Active, not recruiting NCT02796287
4 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

38
Temporal Lobe, Brain, Heart, Cortex, Testes, Caudate Nucleus, Pituitary

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 577)
# Title Authors Year
1
Decreased Metabolism in the Posterior Medial Network with Concomitantly Increased Metabolism in the Anterior Temporal Network During Transient Global Amnesia. ( 29038979 )
2017
2
The Day That Went Missing: A First-Person Account of Transient Global Amnesia. ( 28323679 )
2017
3
A Case of Transient Global Amnesia with Small Left Putamen Infarction. ( 27863873 )
2017
4
Comprehensive Ultrasound Assessment of the Craniocervical Circulation in Transient Global Amnesia. ( 28850691 )
2017
5
A case of thalamo-mesencephalon infarct presenting as transient global amnesia: do we overlook the diagnosis? ( 28083760 )
2017
6
Transient global amnesia: The cerebral Takotsubo? ( 28431611 )
2017
7
Transient global amnesia in immediate postoperative period: A diagnostic dilemma. ( 28235512 )
2017
8
Incidental Hippocampal Hyperintensity on Diffusion-weighted MRI: Individual Susceptibility to Transient Global Amnesia. ( 28644249 )
2017
9
Seasonal Variation in the Incidence of Transient Global Amnesia in South Korea. ( 28831787 )
2017
10
Repetitive Questioning and Writing in a Patient with Transient Global Amnesia. ( 29057635 )
2017
11
Transient global amnesia. ( 28936081 )
2017
12
Transient global amnesia: current perspectives. ( 29123402 )
2017
13
Transient global amnesia: clinical and imaging features. ( 29024985 )
2017
14
Vascular Risk Factors and Internal Jugular Venous Flow in Transient Global Amnesia: A Study of 165 Japanese Patients. ( 28669658 )
2017
15
Reversible Cerebral Vasoconstriction Syndrome Presenting with Transient Global Amnesia. ( 28626186 )
2017
16
Long-Term Outcome in Patients With Transient Global Amnesia: A Population-Based Study. ( 28185658 )
2017
17
Transient global amnesia following a whole-body cryotherapy session. ( 29030365 )
2017
18
Adult-onset neuronal intranuclear inclusion disease presented transient global amnesia-a case report. ( 28552870 )
2017
19
"Once again she forgets everything!": a patient with four episodes of transient global amnesia within less than 5A years. ( 28942504 )
2017
20
Simultaneous transient global amnesia and right MCA stroke after Valsalva manoeuvre. ( 28433970 )
2017
21
Transient Global Amnesia: Commentary on Trip Gabriel's First-Person Account. ( 28323680 )
2017
22
Takotsubo cardiomyopathy and transient global amnesia: a shared aetiology. ( 28710234 )
2017
23
Transient Global Amnesia ( 28723030 )
2017
24
Long-term sequelae of hippocampal lesions in patients with transient global amnesia: A multiparametric MRI study. ( 28884957 )
2017
25
Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia. ( 28366339 )
2017
26
Cortical morphology in patients with transient global amnesia. ( 29299390 )
2017
27
Posterior hippocampal stroke presenting with transient global amnesia. ( 28004602 )
2016
28
Transient global amnesia: Only in already disrupted neuronal integrity of memory network? ( 27538630 )
2016
29
Transient Global Amnesia: Emergency Department Evaluation And Management. ( 27416582 )
2016
30
Transient global amnesia revealing multiple sclerosis. ( 26830923 )
2016
31
Recurrent transient global amnesia as presenting symptoms of CADASIL. ( 27830070 )
2016
32
A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions. ( 27354927 )
2016
33
Transient Global Amnesia After Cerebral Angiography With Iomeprol: A Case Report. ( 27175660 )
2016
34
Seasonal Changes in the Incidence of Transient Global Amnesia. ( 27095523 )
2016
35
Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. ( 27741293 )
2016
36
Bilateral Reversible Diffusion Weighted MRI Abnormalities in Transient Global Amnesia. ( 28405991 )
2016
37
Transient global amnesia: emergency department evaluation and management [digest]. ( 28745847 )
2016
38
Transient Global Amnesia following Neural and Cardiac Angiography May Be Related to Ischemia. ( 27419129 )
2016
39
Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery. ( 27535207 )
2016
40
Implicit Learning in Transient Global Amnesia and the Role of Stress. ( 27909401 )
2016
41
Transient epileptic amnesia secondary to hippocampal dysplasia mimicking transient global amnesia. ( 27821268 )
2016
42
Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption. ( 26690067 )
2015
43
In reply--Familial Transient Global Amnesia. ( 25939946 )
2015
44
Value of dynamic susceptibility contrast perfusion MRI in the acute phase of transient global amnesia. ( 25803440 )
2015
45
A rare case of aortic dissection presenting as pure transient global amnesia. ( 26659651 )
2015
46
The structural connectivity of the recurrent transient global amnesia. ( 26467990 )
2015
47
Of hearts and minds: A case of simultaneous transient global amnesia and regional left ventricular dysfunction. ( 26151711 )
2015
48
Transient global amnesia after stellate ganglion block. ( 25686564 )
2015
49
Voxel seed coherent source analysis on transient global amnesia patients. ( 26736343 )
2015
50
Obstruction of Venous Drainage Linked to Transient Global Amnesia. ( 26173146 )
2015

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 EP300 FOS KLF6
2 11 BDNF FOS PRB1 SELP

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.5 BDNF CRLF1 PSEN1
2 response to oxidative stress GO:0006979 9.43 MBL2 PRNP PSEN1
3 cellular response to amyloid-beta GO:1904646 9.37 PRNP PSEN1
4 calcium-mediated signaling using intracellular calcium source GO:0035584 9.16 PRNP SELP
5 modulation of age-related behavioral decline GO:0090647 8.96 PRNP PSEN1
6 neuron projection maintenance GO:1990535 8.62 PRNP PSEN1

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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