MCID: TRN012
MIFTS: 39

Transient Global Amnesia malady

Rare diseases, Neuronal diseases, Mental diseases categories

Aliases & Classifications for Transient Global Amnesia

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Aliases & Descriptions for Transient Global Amnesia:

Name: Transient Global Amnesia 10 45 12
Amnesia, Transient Global 65 36
 
Tga 45


Classifications:



External Ids:

Disease Ontology10 DOID:13027
NCIt42 C85198
MeSH36 D020236
ICD9CM29 437.7
ICD1027 G45.4

Summaries for Transient Global Amnesia

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NIH Rare Diseases:45 Transient global amnesia (tga) is a condition characterized by sudden onset of memory loss and confusion. affected individuals are often disoriented in regard to time and place but usually remember their identity and can recognize family members. tga typically lasts for hours, although its duration may range from minutes to days. individuals usually have only one episode of tga during their life, although the condition reoccurs in about 5-25 percent of people. affected individuals do not experience symptoms after the episode of amnesia has resolved. last updated: 8/12/2014

MalaCards based summary: Transient Global Amnesia, also known as amnesia, transient global, is related to cerebritis and ischemia. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A, CGMP-Specific), and among its related pathways are Immune response_IL-12 signaling pathway and BDNF signaling pathway. Affiliated tissues include cortex, brain and temporal lobe, and related mouse phenotype hematopoietic system.

Disease Ontology:10 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia:68 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

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Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to transient global amnesia

Symptoms for Transient Global Amnesia

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Drugs & Therapeutics for Transient Global Amnesia

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Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Midazolamapproved, illicitPhase 4, Phase 159759467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
Dormicum
 
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam Hydrochloride
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
2
Propofolapproved, investigationalPhase 4, Phase 18532078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
3
DexmedetomidineapprovedPhase 1420113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
Dexdor (T)
 
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidine Hydrochloride
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex
Precedex (TN)
Tocris-2023
ZINC04632106
4
ThiopentalapprovedPhase 12776-75-53000715
Synonyms:
()Thiopental solution
(+-)-Thiopental
(+/-)-THIOPENTAL
(+/-)Thiopental solution
2-Thio-5-ethyl-5-sec-pentylbarbituric acid
4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI)
5-24-09-00172 (Beilstein Handbook Reference)
5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione
5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
59709-53-4
76-75-5
AC-16029
AC1MHDBY
AC1Q2UJN
BRD-A72603112-236-02-4
BRN 0209361
BSPBio_003301
Bitaryl
C07521
C11H18N2O2S
CHEBI:102166
CHEMBL441
CID3000715
DB00599
DivK1c_000993
EINECS 200-984-3
I14-14129
IDI1_000993
Intraval
KBio1_000993
KBio2_002272
KBio2_004840
 
KBio2_007408
KBio3_002803
KBioGR_001010
KBioSS_002273
LS-24395
NCGC00159524-01
NINDS_000993
Omexolon
Penthiobarbital
Pentothal
Pentothiobarbital
SPBio_002215
Sodium Pentothal
Spectrum2_001998
Spectrum3_001781
Spectrum4_000575
Spectrum5_001692
Spectrum_001786
T1019_SIGMA
T1022_FLUKA
T1022_SIGMA
Thiomebumal
Thiomebumalum
Thionembutal
Thiopental
Thiopental [BAN]
Thiopentobarbital
Thiopentobarbitone
Thiopentobarbituric acid
Thiopentone
Thiothal
Tiopentale
Tiopentale [Italian]
Trapanal
UNII-JI8Z5M7NA3
thiopental
5Adrenergic alpha-2 Receptor AgonistsPhase 1732

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative MedicationCompletedNCT01976845Phase 4
2Effect of Affective Content on Drug Induced Amnesia of Episodic MemoryCompletedNCT00142493Phase 1
3Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted ProstatectomyCompletedNCT01905488
4Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute PhaseRecruitingNCT02010853
5Propofol's Hypnotic and Memory EffectsActive, not recruitingNCT00576615
6Neuropsycholgy and Neuroimaging in Transient Global AmnesiaTerminatedNCT02562560

Search NIH Clinical Center for Transient Global Amnesia


Cochrane evidence based reviews: Amnesia, Transient Global

Genetic Tests for Transient Global Amnesia

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Anatomical Context for Transient Global Amnesia

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MalaCards organs/tissues related to Transient Global Amnesia:

33
Cortex, Brain, Temporal lobe, Heart, Testes, Caudate nucleus, Pituitary

Animal Models for Transient Global Amnesia or affiliated genes

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MGI Mouse Phenotypes related to Transient Global Amnesia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.3CRLF1, EP300, FOS, JAK2, KLF6, MBL2

Publications for Transient Global Amnesia

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Articles related to Transient Global Amnesia:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Hyperhomocysteinemia Association With Transient Global Amnesia: A Rare Case Report. (26417562)
2015
2
Teaching NeuroImages: Hippocampal foci of restricted diffusion in transient global amnesia. (26574541)
2015
3
Transient global amnesia associated with a unilateral infarction of the fornix: case report and review of the literature. (25628601)
2014
4
Reversible functional connectivity disturbances during transient global amnesia. (24623317)
2014
5
Stress-related factors in the emergence of transient global amnesia with hippocampal lesions. (25221484)
2014
6
Cardiac troponin T elevation associated with transient global amnesia: another differential diagnosis of 'troponosis' (24448751)
2014
7
Transient global amnesia and neurological events: the framingham heart study. (23675365)
2013
8
Clinical Experience of Modified Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia: An 8-Year Large-Scale Clinical Study. (23551898)
2013
9
Transient global amnesia, cerebral veins, and the need to find the 'smoking gun'. (22821610)
2012
10
Transient global amnesia: a case report. (22949910)
2012
11
Transient global amnesia as a revealing sign of giant transtentorial meningioma: case report and review of the literature. (21629022)
2011
12
Unmasking aortic dissection in patients of transient global amnesia: case report and diagnostic algorithm for the emergency department. (22715266)
2011
13
Transient global amnesia in a collegiate baseball player with type I diabetes mellitus: a case report. (21669103)
2011
14
What doctors should not forget about transient global amnesia. (20715896)
2010
15
Aortic dissection as a possible cause of pure transient global amnesia: a case report and literature review. (19294333)
2009
16
Long lasting recurrent familiar transient global amnesia after betablocker treatment withdrawal: case report. (18283253)
2008
17
Recurrent transient global amnesia at high altitude. (18800962)
2008
18
Transient global amnesia after dobutamine--atropine stress echocardiography. (17698416)
2008
19
Transient global amnesia associated with the infusion of DMSO-cryopreserved autologous peripheral blood stem cells. (18310533)
2008
20
Classical diseases revisited: transient global amnesia. (17403949)
2007
21
Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. (17522744)
2007
22
The relationship between working memory and episodic memory disorders in transient global amnesia. (16697428)
2006
23
Evidence of acute ischemic tissue change in transient global amnesia in magnetic resonance imaging: case report and literature review. (15746236)
2005
24
Diffusion MRI in pure transient global amnesia associated with bilateral vertebral artery dissection. (14981348)
2004
25
Time course of focal slow wave activity in transient ischemic attacks and transient global amnesia as measured by magnetoencephalography. (11059893)
2000
26
Transient global amnesia, migraine, thalamic infarct, dihydroergotamine, and sumatriptan. (10759939)
2000
27
Clinical features, vascular risk factors, and prognosis for transient global amnesia in Chinese patients. (17895178)
1999
28
Perfusion- and diffusion-weighted magnetic resonance imaging in transient global amnesia. (10408577)
1999
29
Transient global amnesia triggered by mild head injury. (9653523)
1998
30
Aetiology of transient global amnesia. (9717945)
1998
31
Acute confusional migraine: variant of transient global amnesia. (7779209)
1995
32
Sexual intercourse as a precipitating factor of transient global amnesia. (8411784)
1993
33
Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. (8229038)
1993
34
Emotional arousal-induced transient global amnesia. A clue to the neural transcription of emotion? (1311457)
1992
35
Transient global amnesia associated with a right sphenoid ridge meningioma: a case report. (2177363)
1990
36
Transient global amnesia, epilepsy, and migraine: diagnostic comparisons and distinctions. (2505176)
1989
37
Transient global amnesia and left frontal haemorrhage. (3174526)
1988
38
Transient global amnesia precipitated by emotion in an adolescent. (3209845)
1988
39
Transient global amnesia: characterization of anterograde and retrograde amnesia. (3340282)
1988
40
Transient global amnesia: an analysis of 19 cases. (3623877)
1987
41
Transient global amnesia. (3683891)
1987
42
Transient global amnesia after coronary angiography. (3720046)
1986
43
Transient global amnesia. (6487093)
1984
44
Computer tomography in transient global amnesia. (7094948)
1982
45
Transient global amnesia due to glioma in the dominant hemisphere. (7188641)
1980
46
Transient global amnesia and temporary memory loss. (7393049)
1980
47
Transient global amnesia. (424819)
1979
48
Transient global amnesia: manifestation of medial temporal lobe epilepsy. (455733)
1979
49
Transient global amnesia. Report of a case secondary to bilateral middle cerebral artery involvement. (722148)
1978
50
Transient global amnesia. (5347005)
1969

Variations for Transient Global Amnesia

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Expression for genes affiliated with Transient Global Amnesia

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Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for genes affiliated with Transient Global Amnesia

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Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4JAK2, SELP
29.1BDNF, FOS, JAK2
39.0EP300, FOS, JAK2
4
Show member pathways
9.0EP300, FOS, JAK2
58.9BDNF, FOS, MBL2, SELP
6
Show member pathways
8.9BDNF, EP300, FOS, PDE4A

GO Terms for genes affiliated with Transient Global Amnesia

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Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to nerve growth factor stimulusGO:199009010.3BDNF, EP300
2response to light stimulusGO:000941610.1BDNF, FOS
3positive regulation of protein import into nucleus, translocationGO:003316010.0EP300, JAK2
4positive regulation of DNA bindingGO:00433889.9EP300, JAK2
5positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.6BDNF, EP300, JAK2
6cellular response to dexamethasone stimulusGO:00715499.6EP300, JAK2
7response to tumor necrosis factorGO:00346129.5BDNF, EP300, JAK2
8response to organic cyclic compoundGO:00140709.3EP300, FOS, SELP
9negative regulation of neuron apoptotic processGO:00435248.9BDNF, CRLF1, JAK2, PSEN1
10response to oxidative stressGO:00069798.8JAK2, MBL2, PSEN1

Molecular functions related to Transient Global Amnesia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-nucleotide phosphodiesterase activityGO:00041149.7PDE4A, PDE5A

Sources for Transient Global Amnesia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet