TGA
MCID: TRN012
MIFTS: 39

Transient Global Amnesia (TGA) malady

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Transient Global Amnesia

Aliases & Descriptions for Transient Global Amnesia:

Name: Transient Global Amnesia 12 50 14
Amnesia, Transient Global 42 69
Tga 50

Classifications:



External Ids:

Disease Ontology 12 DOID:13027
ICD10 33 G45.4
ICD9CM 35 437.7
MeSH 42 D020236
NCIt 47 C85198
UMLS 69 C0338591

Summaries for Transient Global Amnesia

NIH Rare Diseases : 50 transient global amnesia (tga) is a condition characterized by sudden onset of memory loss and confusion. during an episode of tga, a person is not able to make new memories. the person may be disoriented in regard to time and place, but can remember who they are and can recognize family members. tga typically lasts for several hours, but can last up to ten hours. since no memories are made during a tga episode, the person will never remember what happened during this period, but all other memory is usually intact. most people have only one episode of tga during their lifetime. the underlying cause of tga is unclear. there is no specific treatment for tga as it usually resolves on its own. last updated: 10/31/2016

MalaCards based summary : Transient Global Amnesia, also known as amnesia, transient global, is related to transposition of the great arteries and transposition of the great arteries, dextro-looped 1. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Development HGF signaling pathway and cAMP signaling pathway. The drugs Midazolam and Propofol have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and heart.

Disease Ontology : 12 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia : 71 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 transposition of the great arteries 11.6
2 transposition of the great arteries, dextro-looped 1 11.5
3 congenitally corrected transposition of the great arteries 11.3
4 transposition of great arteries, dextro-looped 3 11.0
5 transposition of the great arteries, dextro-looped 2 11.0
6 med13l syndrome 10.9
7 conotruncal heart malformations 10.7
8 congenitally uncorrected transposition of the great arteries with cardiac malformation 10.7
9 dextro-looped transposition of the great arteries 10.7
10 congenitally uncorrected transposition of the great arteries with coarctation 10.7
11 cerebritis 10.5
12 ischemia 10.2
13 pancreatitis 10.1 EP300 PSEN1
14 epilepsy 10.1
15 right atrial isomerism 10.1 CRLF1 KANTR
16 cortical deafness 10.1 EP300 KANTR
17 rapidly progressive glomerulonephritis 10.1 ALDH7A1 PDE5A
18 urethritis 10.0 KANTR PSEN1
19 chronic tubotympanic suppurative otitis media 10.0 CRLF1 KANTR
20 autism spectrum disorder 10.0 BDNF EP300 PSEN1
21 retrograde amnesia 10.0
22 neuronitis 10.0
23 encephalitis 10.0
24 thrombosis 10.0
25 acquired metabolic disease 10.0 KANTR PSEN1
26 apocrine adenosis of breast 9.9 CA1 FOS
27 angina pectoris 9.9 EP300 KANTR PSEN1
28 heparin-induced thrombocytopenia 9.9
29 acute myocardial infarction 9.9
30 hydrocephalus 9.9
31 herpes simplex 9.9
32 hyperhomocysteinemia 9.9
33 thrombocytopenia 9.9
34 head injury 9.9
35 aphasia 9.9
36 myocardial infarction 9.9
37 siberian tick typhus 9.8 BDNF FOS PSEN1
38 situs inversus 9.8
39 left ventricular outflow tract obstruction 9.8
40 ventricular septal defect 9.8
41 thalassemia 9.8
42 hemophilia 9.8
43 heart disease 9.8
44 cortical blindness 9.8
45 dystonia 9.8
46 herpes simplex encephalitis 9.8
47 arachnoiditis 9.8
48 viral encephalitis 9.8
49 sneddon syndrome 9.8
50 parametritis 9.8

Comorbidity relations with Transient Global Amnesia via Phenotypic Disease Network (PDN):


Hypertension, Essential Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to Transient Global Amnesia

Symptoms & Phenotypes for Transient Global Amnesia

Drugs & Therapeutics for Transient Global Amnesia

Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1 2078-54-8 4943
3 Adjuvants, Anesthesia Phase 4,Phase 1
4 Anesthetics Phase 4,Phase 1
5 Anesthetics, General Phase 4,Phase 1
6 Anesthetics, Intravenous Phase 4,Phase 1
7 Anti-Anxiety Agents Phase 4,Phase 1
8 Central Nervous System Depressants Phase 4,Phase 1
9 GABA Agents Phase 4,Phase 1
10 GABA Modulators Phase 4,Phase 1
11 Hypnotics and Sedatives Phase 4,Phase 1
12 Neurotransmitter Agents Phase 4,Phase 1
13 Pharmaceutical Solutions Phase 4,Phase 1
14 Psychotropic Drugs Phase 4,Phase 1
15 Tranquilizing Agents Phase 4,Phase 1
16
Dexmedetomidine Approved, Vet_approved Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
17
Thiopental Approved, Vet_approved Phase 1 76-75-5 3000715
18 Adrenergic Agents Phase 1
19 Adrenergic Agonists Phase 1
20 Adrenergic alpha-2 Receptor Agonists Phase 1
21 Adrenergic alpha-Agonists Phase 1
22 Analgesics Phase 1
23 Analgesics, Non-Narcotic Phase 1
24 Anticonvulsants Phase 1
25 Peripheral Nervous System Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication Completed NCT01976845 Phase 4
2 Effect of Affective Content on Drug Induced Amnesia of Episodic Memory Completed NCT00142493 Phase 1
3 Pilot Study of Spinal Manipulation for Chronic Neck Pain Terminated NCT00030004 Phase 1
4 Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase Completed NCT02010853
5 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
6 Propofol's Hypnotic and Memory Effects Completed NCT00576615
7 Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia Recruiting NCT02796287
8 Neuropsycholgy and Neuroimaging in Transient Global Amnesia Terminated NCT02562560

Search NIH Clinical Center for Transient Global Amnesia

Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

Anatomical Context for Transient Global Amnesia

MalaCards organs/tissues related to Transient Global Amnesia:

39
Temporal Lobe, Brain, Heart, Cortex, Testes, Pituitary, Caudate Nucleus

Publications for Transient Global Amnesia

Articles related to Transient Global Amnesia:

(show top 50) (show all 551)
id Title Authors Year
1
A Case of Transient Global Amnesia with Small Left Putamen Infarction. ( 27863873 )
2017
2
A case of thalamo-mesencephalon infarct presenting as transient global amnesia: do we overlook the diagnosis? ( 28083760 )
2017
3
Posterior hippocampal stroke presenting with transient global amnesia. ( 28004602 )
2016
4
Transient Global Amnesia: Emergency Department Evaluation And Management. ( 27416582 )
2016
5
Transient Global Amnesia following Neural and Cardiac Angiography May Be Related to Ischemia. ( 27419129 )
2016
6
Transient global amnesia revealing multiple sclerosis. ( 26830923 )
2016
7
Implicit Learning in Transient Global Amnesia and the Role of Stress. ( 27909401 )
2016
8
Transient epileptic amnesia secondary to hippocampal dysplasia mimicking transient global amnesia. ( 27821268 )
2016
9
A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions. ( 27354927 )
2016
10
Seasonal Changes in the Incidence of Transient Global Amnesia. ( 27095523 )
2016
11
Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and after recovery. ( 27535207 )
2016
12
Recurrent transient global amnesia as presenting symptoms of CADASIL. ( 27830070 )
2016
13
Transient global amnesia: Only in already disrupted neuronal integrity of memory network? ( 27538630 )
2016
14
Transient Global Amnesia After Cerebral Angiography With Iomeprol: A Case Report. ( 27175660 )
2016
15
Transient Global Amnesia Deteriorates the Network Efficiency of the Theta Band. ( 27741293 )
2016
16
Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption. ( 26690067 )
2015
17
Teaching NeuroImages: Hippocampal foci of restricted diffusion in transient global amnesia. ( 26574541 )
2015
18
The structural connectivity of the recurrent transient global amnesia. ( 26467990 )
2015
19
Transient Global Amnesia with Reversible White Matter Lesions: A Variant of Posterior Reversible Encephalopathy Syndrome? ( 26697246 )
2015
20
Transient global amnesia and broken heart syndrome: two faces of one pathology. ( 25822581 )
2015
21
Pre-existing structural abnormalities of the limbic system in transient global amnesia. ( 25818164 )
2015
22
Transient global amnesia and brain tumour: chance concurrence or aetiological association? Case report and systematic literature review. ( 25802501 )
2015
23
Transient Global Amnesia Triggered by Migraine in a French Tertiary-Care Center: An 11-Year Retrospective Analysis. ( 25877480 )
2015
24
Familial transient global amnesia. ( 25939944 )
2015
25
Of hearts and minds: A case of simultaneous transient global amnesia and regional left ventricular dysfunction. ( 26151711 )
2015
26
Comment on " Transient memory impairment and transient global amnesia induced by Photodynamic Therapy". ( 26264886 )
2015
27
Voxel seed coherent source analysis on transient global amnesia patients. ( 26736343 )
2015
28
'What is happening?': a case of transient global amnesia. ( 26646338 )
2015
29
Thalamic Amnesia Mimicking Transient Global Amnesia. ( 26075467 )
2015
30
Stronger pharmacological cortisol suppression and anticipatory cortisol stress response in transient global amnesia. ( 25805980 )
2015
31
CTP in Transient Global Amnesia: A Single-Center Experience of 30 Patients. ( 26045576 )
2015
32
In reply--Familial Transient Global Amnesia. ( 25939946 )
2015
33
Transient global amnesia. ( 25659242 )
2015
34
Transient global amnesia and Takotsubo syndrome: would cerebral blood flow brain scan be of any help? ( 25957759 )
2015
35
Is a cancer diagnosis associated with subsequent risk of transient global amnesia? ( 25849383 )
2015
36
Transient memory impairment and transient global amnesia induced by photodynamic therapy. ( 26122551 )
2015
37
Transient global amnesia with a hippocampal lesion followed by transient epileptic amnesia. ( 26362391 )
2015
38
Transient Global Amnesia as a Presenting Manifestation of Cerebral Venous Thrombosis. ( 26222971 )
2015
39
Transient global amnesia like syndrome associated with acute infarction of the corpus callosum: a case report. ( 26643084 )
2015
40
Value of dynamic susceptibility contrast perfusion MRI in the acute phase of transient global amnesia. ( 25803440 )
2015
41
Hyperhomocysteinemia Association With Transient Global Amnesia: A Rare Case Report. ( 26417562 )
2015
42
Transient global amnesia. ( 26646345 )
2015
43
Influence of depressive symptoms on memory inA transient global amnesia. ( 26179568 )
2015
44
The Still Enigmatic Syndrome of Transient Global Amnesia: Interactions Between Neurological and Psychopathological Factors. ( 25868986 )
2015
45
Obstruction of Venous Drainage Linked to Transient Global Amnesia. ( 26173146 )
2015
46
Transient Global Amnesia as the First Clinical Symptom for Malignant B-Cell Lymphoma with Central Nervous System Involvement. ( 26236514 )
2015
47
Hippocampal modifications in transient global amnesia. ( 25769554 )
2015
48
Transient global amnesia with intracranial vertebral artery dissection and hippocampal CA1 lesion. ( 26238898 )
2015
49
A rare case of aortic dissection presenting as pure transient global amnesia. ( 26659651 )
2015
50
Transient global amnesia after stellate ganglion block. ( 25686564 )
2015

Variations for Transient Global Amnesia

Expression for Transient Global Amnesia

Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for Transient Global Amnesia

GO Terms for Transient Global Amnesia

Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 8.8 BDNF CRLF1 PSEN1

Sources for Transient Global Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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