TGA
MCID: TRN012
MIFTS: 42

Transient Global Amnesia (TGA) malady

Neuronal diseases category

Summaries for Transient Global Amnesia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Transient global amnesia (tga) is a condition characterized by sudden onset of memory loss and confusion. affected individuals are often disoriented in regard to time and place but usually remember their identity and can recognize family members. tga typically lasts for hours, although its duration may range from minutes to days. individuals usually have only one episode of tga during their life, although the condition reoccurs in about 5-25 percent of people. affected individuals do not experience symptoms after the episode of amnesia has resolved. last updated: 6/2/2009

MalaCards: Transient Global Amnesia, also known as amnesia, transient global, is related to migraine and ischemia. An important gene associated with Transient Global Amnesia is CRLF1 (cytokine receptor-like factor 1). The compounds cyclothiazide and chlorpromazine have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, brain and heart.

Disease Ontology:8 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia:63 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Aliases & Classifications for Transient Global Amnesia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

transient global amnesia 8 42
amnesia, transient global 60
tga 42


External Ids:

Disease Ontology8 DOID:13027
NCIt39 C85198
ICD9CM27 437.7
MeSH34 D020236
ICD1025 G45.4

Related Diseases for Transient Global Amnesia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.3PDE5A, APOH
2ischemia30.9PDE5A, BDNF
3cerebritis10.9
4meningioma10.6
5retrograde amnesia10.4
6encephalitis10.4
7stroke, ischemic10.4
8neuronitis10.4
9acute myocardial infarction10.4
10aphasia10.4
11herpes simplex10.4
12hydrocephalus10.4
13myocardial infarction10.4
14thrombocytopenia10.4
15transient cerebral ischemia10.4
16transposition of the great arteries, dextro-looped 210.2
17transposition of the great arteries, dextro-looped 110.2
18transposition of great arteries, dextro-looped 310.2
19arteriovenous fistula10.2
20sneddon syndrome10.2
21parametritis10.2
22antiphospholipid syndrome10.2
23patent foramen ovale10.2
24temporal lobe epilepsy10.2
25dissociative amnesia10.2
26arachnoiditis10.2
27hyperhomocysteinemia10.2
28dissecting aortic aneurysm10.2
29viral encephalitis10.2
30cortical blindness10.2
31anterograde amnesia10.2
32carotid artery occlusion10.2
33obstructive hydrocephalus10.2
34adenoma10.2
35aortic aneurysm10.2
36dementia10.2
37diabetes mellitus10.2
38hypertension10.2
39pituitary adenoma10.2
40scleroderma10.2
41congenitally corrected transposition of the great arteries10.2
42transposition of the great arteries10.2
43situs inversus10.1
44thalassemia10.1
45hemophilia10.1
46labyrinthitis10.0CRLF1
47sjogren's syndrome10.0APOH
48breast cancer10.0KLF6, FUT3
49pulmonary embolism10.0APOH
50ischemic optic neuropathy10.0PDE5A

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to transient global amnesia

Clinical Features for Transient Global Amnesia

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Drugs & Therapeutics for Transient Global Amnesia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Transient Global Amnesia

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Anatomical Context for Transient Global Amnesia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Transient Global Amnesia:

32
Temporal lobe, Brain, Heart, Cortex, Testes, Pituitary, Thalamus, Prefrontal cortex, Caudate nucleus

Animal Models for Transient Global Amnesia or affiliated genes

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Publications for Transient Global Amnesia

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Sources:
50PubMed
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Articles related to Transient Global Amnesia:

(show top 50)    (show all 479)
idTitleAuthorsYear
1
Clinical Experience of Modified Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia: An 8-Year Large-Scale Clinical Study. (23551898)
2013
2
Magnetic resonance imaging in transient global amnesia: lessons learned from 198 cases. (22422060)
2012
3
Jugular veins in transient global amnesia: innocent bystanders. (22811457)
2012
4
Recognition memory without awareness during transient global amnesia. (22042379)
2011
5
Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory. (20538952)
2010
6
Transient global amnesia after ablation of premature ventricular beats arising from the right coronary cusp. (20811539)
2010
7
Transient global amnesia caused by painless aortic dissection. (21686553)
2009
8
Diffusion magnetic resonance imaging in transient global amnesia. (19330233)
2009
9
Recurrent transient global amnesia with intrathecal baclofen. (18349207)
2008
10
Transient global amnesia after breathing hyperoxic mixtures in otherwise regular dives. (17920188)
2008
11
Transient global amnesia: cerebral venous outflow impairment-insight from the abnormal flow patterns of the internal jugular vein. (17629610)
2007
12
Transient global amnesia following coronary angiography. (16534174)
2006
13
Transient global amnesia heralding basilar artery thrombosis. (16311149)
2005
14
Clinical features, risk factors, and prognosis in transient global amnesia: a follow-up study. (15804264)
2005
15
Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. (15774436)
2005
16
Transient global amnesia -- not always a benign process. (15242413)
2004
17
Aortic dissection presenting with transient global amnesia-like symptoms. (15623727)
2004
18
Transient global amnesia and transient topographical amnesia: an observation favoring the hypothesis of a common pathogenesis. (12814122)
2003
19
Transient global amnesia after sildenafil (Viagra) use. (12221181)
2002
20
Transient global amnesia, migraine, thalamic infarct, dihydroergotamine, and sumatriptan. (10759939)
2000
21
Multimodal event-related potential P3 after transient global amnesia. (10809919)
2000
22
Disturbance of venous flow patterns in patients with transient global amnesia. (11130530)
2000
23
Hippocampal ischemia in a patient who experienced transient global amnesia after undergoing cerebral angiography. Case illustration. (10433329)
1999
24
Transient global amnesia at high altitude. (10328714)
1999
25
Transient global amnesia. (9488799)
1997
26
ED evaluation of transient global amnesia. (9326868)
1997
27
An increased frequency of patent foramen ovale in patients with transient global amnesia. Analysis of 53 consecutive patients. (8660151)
1996
28
Transient global amnesia and transient ischemic attack. Natural history, vascular risk factors, and associated conditions. (7660394)
1995
29
Exercise-induced transient global amnesia in a patient with subclavian steal. (8160958)
1994
30
Sexual intercourse as a precipitating factor of transient global amnesia. (8411784)
1993
31
Memory, transient global amnesia, and history taking. (8235571)
1993
32
Transient global amnesia. A case control study. (1559158)
1992
33
The complex episode of transient global amnesia. (2096246)
1990
34
The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up. (2194627)
1990
35
Transient global amnesia followed by vertebrobasilar ischemia in a case of dolichoectatic basilar artery. (2085087)
1990
36
Cerebral blood flow and transient global amnesia. (2341858)
1990
37
Transient global amnesia, epilepsy, and migraine: diagnostic comparisons and distinctions. (2505176)
1989
38
Transient global amnesia and antiphospholipid antibodies. (2706824)
1989
39
Transient global amnesia and falcotentorial meningioma--a case report. (2796031)
1989
40
Neuropsychological findings during a transient global amnesia attack and its follow-up. (3957632)
1986
41
Neuropsychological functions in the follow-up of transient global amnesia. (4031918)
1985
42
Transient global amnesia and meningioma. (3990976)
1985
43
Transient global amnesia. (424819)
1979
44
Transient global amnesia. (448817)
1979
45
Transient global amnesia. (553404)
1979
46
Brain stem dysfunction in transient global amnesia. (505488)
1979
47
Transient global amnesia with a dissecting aortic aneurysm. (426678)
1979
48
Transient global amnesia. Report of a case secondary to bilateral middle cerebral artery involvement. (722148)
1978
49
Transient global amnesia associated with cardiac arrhythmia and digitalis intoxication. (1179459)
1975
50
Pathogenesis and natural history of transient global amnesia. (4836531)
1974

Genetic Variations for Transient Global Amnesia

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Expression for genes affiliated with Transient Global Amnesia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Global Amnesia

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Pathways for genes affiliated with Transient Global Amnesia

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Compounds for genes affiliated with Transient Global Amnesia

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Transient Global Amnesia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cyclothiazide28 44 1111.7BDNF, CA1
2chlorpromazine44 28 49 1112.4BDNF, APOH
3cocaine44 1110.1RABEP2, APOH, BDNF
4gold448.9APOH, PDE5A, BDNF
5indomethacin44 59 28 1111.7PDE5A, CA1, BDNF
6norepinephrine44 11 2410.7PDE5A, CA1, BDNF
7dopamine44 28 11 2411.5RABEP2, PDE5A, BDNF
8arginine448.4HNRNPC, CA1, PDE5A, APOH
9hydrogen44 249.4PDE5A, CA1, BDNF
10zinc44 249.2APOH, PDE5A, CA1, BDNF, KLF6
11estrogen448.0KLF6, BDNF, PDE5A, APOH, RABEP2

GO Terms for genes affiliated with Transient Global Amnesia

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16Gene Ontology
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Biological processes related to Transient Global Amnesia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ureteric bud developmentGO:0016579.6CRLF1, BDNF

Products for genes affiliated with Transient Global Amnesia

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Sources for Transient Global Amnesia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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