MCID: TRN012
MIFTS: 38

Transient Global Amnesia malady

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Transient Global Amnesia

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Aliases & Descriptions for Transient Global Amnesia:

Name: Transient Global Amnesia 10 45 12
Amnesia, Transient Global 36 65
 
Tga 45

Classifications:



External Ids:

Disease Ontology10 DOID:13027
ICD1027 G45.4
ICD9CM29 437.7
MeSH36 D020236
NCIt42 C85198
UMLS65 C0338591

Summaries for Transient Global Amnesia

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NIH Rare Diseases:45 Transient global amnesia (tga) is a condition characterized by sudden onset of memory loss and confusion. affected people are often disoriented in regard to time and place, but usually remember their identity and can recognize family members. tga typically lasts for several hours, and rarely for up to 24 hours. while most people have only one episode of tga during their lifetime, 5-25% of people have a recurrence. the underlying cause of tga is unclear. there is no specific treatment for tga. it resolves on it's own, but memory for events during the episode may be lost. last updated: 2/3/2016

MalaCards based summary: Transient Global Amnesia, also known as amnesia, transient global, is related to wernicke-korsakoff syndrome and transposition of the great arteries, dextro-looped 1. An important gene associated with Transient Global Amnesia is PDE5A (Phosphodiesterase 5A), and among its related pathways are cAMP signaling pathway and Spinal Cord Injury. Affiliated tissues include lung, breast and heart, and related mouse phenotypes are normal and nervous system.

Disease Ontology:10 An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

Wikipedia:68 Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a... more...

Related Diseases for Transient Global Amnesia

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Diseases related to Transient Global Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1wernicke-korsakoff syndrome29.8BDNF, FOS, PSEN1
2transposition of the great arteries, dextro-looped 111.7
3transposition of the great arteries11.6
4conotruncal heart malformations11.3
5congenitally uncorrected transposition of the great arteries with cardiac malformation11.3
6congenitally uncorrected transposition of the great arteries with coarctation11.3
7transposition of the great arteries, dextro-looped 210.6
8transposition of great arteries, dextro-looped 310.6
9breast cancer10.5
10neuronitis10.5
11congenitally corrected transposition of the great arteries10.5
12pancreatitis10.5
13hepatitis10.4
14leukemia10.4
15lymphoma10.4
16endotheliitis10.4
17med13l syndrome10.4
18obesity10.4
19arthritis10.4
20lung cancer10.3
21asthma10.3
22phenylketonuria10.3
23liver disease10.3
24oral squamous cell carcinoma10.3
25graves' disease10.3
26diarrhea10.3
27adenocarcinoma10.3
28cerebritis10.3
29adenoma10.3
30muscular dystrophy10.3
31cardiomyopathy10.3
32cerebral arterial disease10.3CRLF1, EP300
33xerophthalmia10.3ALDH7A1, PDE5A
34schizophrenia10.2
35rheumatoid arthritis10.2
36neuroblastoma10.2
37myocardial infarction10.2
38systemic lupus erythematosus10.2
39renal cell carcinoma10.2
40osteoporosis10.2
41cystic fibrosis10.2
42adult respiratory distress syndrome10.2
43burns10.2
44gastric cancer10.2
45myasthenia gravis10.2
46orofacial cleft10.2
47autism spectrum disorder10.2
48meningoencephalitis10.2
49malignant hypertension10.2
50sarcoma10.2

Graphical network of the top 20 diseases related to Transient Global Amnesia:



Diseases related to transient global amnesia

Symptoms for Transient Global Amnesia

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Drugs & Therapeutics for Transient Global Amnesia

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Drugs for Transient Global Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Propofolapproved, investigationalPhase 4, Phase 19312078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
2
Midazolamapproved, illicitPhase 4, Phase 163559467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
Dormicum
 
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam Hydrochloride
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
3Neurotransmitter AgentsPhase 4, Phase 114795
4Pharmaceutical SolutionsPhase 4, Phase 17004
5AnestheticsPhase 4, Phase 17385
6Tranquilizing AgentsPhase 4, Phase 13597
7Psychotropic DrugsPhase 4, Phase 15501
8Anesthetics, IntravenousPhase 4, Phase 11943
9Hypnotics and SedativesPhase 4, Phase 12032
10Anti-Anxiety AgentsPhase 4, Phase 11529
11Anesthetics, GeneralPhase 4, Phase 12274
12Central Nervous System DepressantsPhase 4, Phase 110016
13GABA ModulatorsPhase 4, Phase 1657
14
DexmedetomidineapprovedPhase 1470113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
Dexdor (T)
 
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidine Hydrochloride
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex
Precedex (TN)
Tocris-2023
ZINC04632106
15
ThiopentalapprovedPhase 13076-75-53000715
Synonyms:
()Thiopental solution
(+-)-Thiopental
(+/-)-THIOPENTAL
(+/-)Thiopental solution
2-Thio-5-ethyl-5-sec-pentylbarbituric acid
4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI)
5-24-09-00172 (Beilstein Handbook Reference)
5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione
5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
59709-53-4
76-75-5
AC-16029
AC1MHDBY
AC1Q2UJN
BRD-A72603112-236-02-4
BRN 0209361
BSPBio_003301
Bitaryl
C07521
C11H18N2O2S
CHEBI:102166
CHEMBL441
CID3000715
DB00599
DivK1c_000993
EINECS 200-984-3
I14-14129
IDI1_000993
Intraval
KBio1_000993
KBio2_002272
KBio2_004840
 
KBio2_007408
KBio3_002803
KBioGR_001010
KBioSS_002273
LS-24395
NCGC00159524-01
NINDS_000993
Omexolon
Penthiobarbital
Pentothal
Pentothiobarbital
SPBio_002215
Sodium Pentothal
Spectrum2_001998
Spectrum3_001781
Spectrum4_000575
Spectrum5_001692
Spectrum_001786
T1019_SIGMA
T1022_FLUKA
T1022_SIGMA
Thiomebumal
Thiomebumalum
Thionembutal
Thiopental
Thiopental [BAN]
Thiopentobarbital
Thiopentobarbitone
Thiopentobarbituric acid
Thiopentone
Thiothal
Tiopentale
Tiopentale [Italian]
Trapanal
UNII-JI8Z5M7NA3
thiopental
16AnticonvulsantsPhase 12249
17Peripheral Nervous System AgentsPhase 118510
18Analgesics, Non-NarcoticPhase 15184
19Adrenergic AgonistsPhase 12331
20Adrenergic AgentsPhase 14204
21Adrenergic alpha-2 Receptor AgonistsPhase 1790
22Adrenergic alpha-AgonistsPhase 11300
23AnalgesicsPhase 19358

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative MedicationCompletedNCT01976845Phase 4
2Effect of Affective Content on Drug Induced Amnesia of Episodic MemoryCompletedNCT00142493Phase 1
3Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted ProstatectomyCompletedNCT01905488
4Propofol's Hypnotic and Memory EffectsCompletedNCT00576615
5Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute PhaseRecruitingNCT02010853
6Neuropsycholgy and Neuroimaging in Transient Global AmnesiaTerminatedNCT02562560

Search NIH Clinical Center for Transient Global Amnesia


Cochrane evidence based reviews: amnesia, transient global

Genetic Tests for Transient Global Amnesia

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Anatomical Context for Transient Global Amnesia

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MalaCards organs/tissues related to Transient Global Amnesia:

33
Lung, Breast, Heart, T cells, Thyroid, Liver, Ovary

Animal Models for Transient Global Amnesia or affiliated genes

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MGI Mouse Phenotypes related to Transient Global Amnesia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.3ALDH7A1, BDNF, EP300, FOS, PCLO, PSEN1
2MP:00036316.9BDNF, CRLF1, EP300, FOS, PCLO, PDE4A

Publications for Transient Global Amnesia

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Articles related to Transient Global Amnesia:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Interferon gamma-inducible protein 16 in primary SjAPgren's syndrome: a novel player in disease pathogenesis? (26271464)
2015
2
DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma. (25712377)
2015
3
Outcomes of cardiovascular disease risk factor screening and referrals in a family planning clinic. (25517351)
2015
4
Potential role of F18 FDG PET-CT as an imaging biomarker for the noninvasive evaluation in uncomplicated skeletal tuberculosis: a prospective clinical observational study. (25070791)
2014
5
Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity. (24558042)
2014
6
Cushing's syndrome induced by high-potency topical corticosteroids. (22591336)
2014
7
Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria. (23878241)
2013
8
Melancholia: past and present. (23547641)
2013
9
Clinical Behavior in Metastatic Brain Disease Is Not Influenced by the Immunological Defense Mediated by CD57 NK-Cells. (22312544)
2012
10
Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II. (21396942)
2011
11
The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis. (20204292)
2010
12
Prevalence of and risk factors for postoperative ileus after small intestinal surgery in two hundred and thirty-three horses. (19573101)
2009
13
Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease. (19381676)
2009
14
Detecting dysphagia in inclusion body myositis. (19603245)
2009
15
Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. (19178938)
2009
16
Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity. (18440519)
2009
17
Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. (18932283)
2008
18
Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways. (18353901)
2008
19
A componential analysis of proverb interpretation in patients with frontal lobe epilepsy and temporal lobe epilepsy: relationships with disease-related factors. (17853125)
2008
20
Transcriptional control of the melanoma malignant phenotype. (18698165)
2008
21
Cephalosporin-induced leukopenia following rechallenge with cefoxitin. (18648015)
2008
22
Role of NF-kappaB in TNF-alpha-induced COX-2 expression in synovial fibroblasts from human TMJ. (17384033)
2007
23
Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation. (16810540)
2007
24
Neurological picture. Horner's syndrome and ipsilateral tongue paresis due to carotid artery dissection. (17369591)
2007
25
Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. (17872946)
2007
26
The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. (15695802)
2005
27
Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. (15897874)
2005
28
Validation of tissue microarray for the immunohistochemical profiling of melanoma. (15091192)
2004
29
Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited. (15143194)
2004
30
Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes. (12907132)
2003
31
Role of Na+/H+ exchanger isoform-1 in human inflammatory bowel disease. (12560852)
2003
32
Computer-assisted orbital volume measurement in the surgical correction of late enophthalmos caused by blowout fractures. (12918556)
2003
33
Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. (14623265)
2003
34
Mitochondrial biogenesis and the role of the protein import pathway. (12544641)
2003
35
Influence of HIV/AIDS infection on some biochemical indicators of the nutritional status]. (12152477)
2002
36
Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons. (12402167)
2002
37
Studies with His475Tyr glutamate carboxipeptidase II polymorphism and neural tube defects. (12210356)
2002
38
Role of host response during severe bacterial infection]. (11582914)
2001
39
Large placental chorioangioma. (11580744)
2001
40
Enterohemorrhagic Escherichia coli and hemolytic-uremic syndrome]. (9381722)
1997
41
Proteolytic activity degrading insulin-like growth factor-binding protein-2, -3, -4, and -5 in healthy growing and atretic follicles in the pig ovary. (9096890)
1997
42
Superoxide dismutase activity in serum of patients with acute cerebral ischemic injury. Correlation with clinical course and infarct size. (9412626)
1997
43
Major histocompatibility complex class II and complement polymorphisms in postpartum thyroiditis. (8640296)
1996
44
Relation of fibrinogen to lifestyles and to cardiovascular risk factors in a working population. (8557447)
1995
45
Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis: case report. (7548511)
1995
46
Hemifacial spasm: successful treatment with felbamate. (7673772)
1995
47
Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function. (8159722)
1994
48
Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. (1400872)
1992
49
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole. (2015598)
1991
50
Echocardiography in mitral valve disease: a review. (3916435)
1985

Variations for Transient Global Amnesia

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Expression for genes affiliated with Transient Global Amnesia

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Search GEO for disease gene expression data for Transient Global Amnesia.

Pathways for genes affiliated with Transient Global Amnesia

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Pathways related to Transient Global Amnesia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.6BDNF, EP300, FOS, PDE4A
28.4BDNF, FOS, MBL2, SELP

GO Terms for genes affiliated with Transient Global Amnesia

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Biological processes related to Transient Global Amnesia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nervous system developmentGO:00073999.1BDNF, EP300, FOS

Sources for Transient Global Amnesia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet