DMTN
MCID: TRN032
MIFTS: 33

Transient Neonatal Diabetes Mellitus (DMTN) malady

Summaries for Transient Neonatal Diabetes Mellitus

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Transient neonatal diabetes mellitus (tndb) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. these cases are referred to as 6q24-related tndb; most (but not all) of these cases are not inherited. other genetic causes include mutations in the kcnj11 and abcc8 genes, which usually cause permanent neonatal diabetes. treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin. last updated: 8/28/2012

MalaCards: Transient Neonatal Diabetes Mellitus, also known as diabetes mellitus, transient neonatal, is related to neonatal diabetes mellitus and diabetes mellitus. An important gene associated with Transient Neonatal Diabetes Mellitus is ZFP57 (ZFP57 zinc finger protein), and among its related pathways are Inwardly rectifying K+ channels and ATP sensitive Potassium channels. The compounds minoxidil and cibenzoline have been mentioned in the context of this disorder. Related mouse phenotype endocrine/exocrine gland.

Wikipedia:63 Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is... more...

Description from OMIM:46 601410

Aliases & Classifications for Transient Neonatal Diabetes Mellitus

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42NIH Rare Diseases, 46OMIM, 60UMLS
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Aliases & Descriptions:

transient neonatal diabetes mellitus 42
diabetes mellitus, transient neonatal 42 46
chromosome 6-associated transient diabetes mellitus 42
diabetes mellitus, 6q24-related transient neonatal 42
diabetes mellitus, transient neonatal, 1 60
tndm 42
dmtn 42


Related Diseases for Transient Neonatal Diabetes Mellitus

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17GeneCards, 18GeneDecks
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Diseases in the Diabetes Mellitus, 6q24-Related Transient Neonatal family:

Neonatal Diabetes Mellitus transient neonatal diabetes mellitus
Diabetes Mellitus, Kcnj11-Related Transient Neonatal Abcc8-Related Transient Neonatal Diabetes Mellitus 2
Diabetes Mellitus, Transient Neonatal 2 Diabetes Mellitus, Transient Neonatal, 3

Diseases related to Transient Neonatal Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1neonatal diabetes mellitus31.6PLAGL1, ABCC8, INS, KCNJ11
2diabetes mellitus31.5ABCC8, INS, IGF1, KCNJ11
3diabetes mellitus, 6q24-related transient neonatal31.1HYMAI, PLAGL1
4diabetic ketoacidosis30.3INS
5permanent neonatal diabetes mellitus30.3ABCC8, INS
6beckwith-wiedemann syndrome30.3ZFP57, ABCC8, PLAGL1
7type 2 diabetes mellitus30.3TPO, ABCC8, INS, IGF1, KCNJ11
8type 1 diabetes mellitus10.4
9abcc8-related transient neonatal diabetes mellitus 210.4
10diabetes mellitus, transient neonatal 210.4
11diabetes mellitus, transient neonatal, 310.4
12prostate cancer10.2
13prostatitis10.2
14diabetes mellitus, kcnj11-related transient neonatal10.2
15malaria10.1
16maturity-onset diabetes of the young10.0
17donohue syndrome10.0INS
18fetal macrosomia10.0INS
19morbid obesity10.0INS
20celiac disease10.0TPO
21myocardial infarction10.0TPO
22familial hyperinsulinism10.0ABCC8, KCNJ11
23goiter10.0TPO
24down syndrome10.0TPO
25dwarfism10.0IGF1
26sheehan syndrome10.0IGF1
27laron syndrome10.0IGF1
28hyperammonemia multi-gene panels10.0ABCC8, KCNJ11
29autonomic neuropathy10.0INS
30hyperinsulinemic hypoglycemia10.0ABCC8, INS
31silver-russell syndrome10.0ZFP57
32gestational diabetes10.0KCNJ11, INS, ABCC8
33insulinoma10.0KCNJ11, INS, ABCC8
34pituitary adenoma10.0ABCC8, IGF1
35rabson-mendenhall syndrome10.0INS, IGF1
36pituitary tumors10.0IGF1, PLAGL1
37epilepsy syndrome10.0ABCC8, ZACN, KCNJ11
38pituitary gland disease10.0IGF1, INS
39acromegaly10.0INS, IGF1
40type 1 diabetes10.0INS, TPO
41anovulation10.0IGF1, INS
42thyrotropin deficiency, isolated10.0TPO, IGF1
43acanthosis nigricans10.0IGF1, INS
44cystic fibrosis10.0ABCC8, INS, KCNJ11
45polycystic ovary syndrome10.0IGF1, INS
46turner syndrome10.0TPO, IGF1
47thyrotoxicosis10.0TPO, INS
48glucose intolerance10.0KCNJ11, IGF1, INS, ABCC8
49hyperinsulinism10.0KCNJ11, IGF1, INS, ABCC8
50hypoglycemia10.0ABCC8, INS, IGF1, KCNJ11

Graphical network of the top 20 diseases related to Transient Neonatal Diabetes Mellitus:



Diseases related to transient neonatal diabetes mellitus

Clinical Features for Transient Neonatal Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

601410

Drugs & Therapeutics for Transient Neonatal Diabetes Mellitus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Transient Neonatal Diabetes Mellitus

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Genetic Tests for Transient Neonatal Diabetes Mellitus

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Anatomical Context for Transient Neonatal Diabetes Mellitus

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Animal Models for Transient Neonatal Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Transient Neonatal Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4TPO, ABCC8, INS, IGF1, KCNJ11

Publications for Transient Neonatal Diabetes Mellitus

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Genetic Variations for Transient Neonatal Diabetes Mellitus

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Transient Neonatal Diabetes Mellitus:

62
id Symbol AA change Variation ID SNP ID
1ZFP57p.Arg166HisVAR_054771
2ZFP57p.His193AsnVAR_054772
3ZFP57p.His374AspVAR_054773

Expression for genes affiliated with Transient Neonatal Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transient Neonatal Diabetes Mellitus

Search GEO for disease gene expression data for Transient Neonatal Diabetes Mellitus.

Pathways for genes affiliated with Transient Neonatal Diabetes Mellitus

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53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Transient Neonatal Diabetes Mellitus

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Transient Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1minoxidil44 28 1112.4ABCC8
2cibenzoline4410.2ABCC8, KCNJ11
3nicorandil44 2811.1KCNJ11, ABCC8
4mgadp4410.1ABCC8, KCNJ11
5cromakalim44 2811.1ABCC8, KCNJ11
6meglitinide4410.0INS, ABCC8
7mitiglinide44 1111.0ABCC8, INS
8Glyburide119.9KCNJ11, ABCC8
9glipizide44 1110.9INS, ABCC8
10chlorpropamide44 1110.9INS, ABCC8
11mecasermin44 1110.8IGF1, INS
12oxandrolone44 1110.8INS, IGF1
13nateglinide44 49 1111.8ABCC8, INS
14acipimox44 2810.7INS, IGF1
15repaglinide44 49 1111.7ABCC8, INS, KCNJ11
16glimepiride44 49 1111.7KCNJ11, INS, ABCC8
17gliclazide44 49 1111.7ABCC8, INS, KCNJ11
18sulfonylurea449.7KCNJ11, INS, ABCC8
19katp449.7KCNJ11, INS, ABCC8
20diazoxide44 59 28 1112.7ABCC8, INS, KCNJ11
21tolbutamide44 49 28 1112.7ABCC8, INS, KCNJ11
22glibenclamide44 28 49 5912.7ABCC8, INS, KCNJ11
23clomiphene citrate449.6IGF1, INS
24octreotide44 59 28 1112.5PLAGL1, INS, IGF1
25cortisone44 2410.5INS, IGF1
26starch449.5INS, IGF1
27hydrocortisone44 2 59 1112.3IGF1, INS, TPO
28potassium44 11 2411.3TPO, ABCC8, ZACN, KCNJ11
29thyroxine44 2410.3IGF1, INS, TPO
30metformin44 49 1111.2ABCC8, INS, IGF1, KCNJ11
31c-peptide449.2KCNJ11, IGF1, INS, TPO
32acth449.0IGF1, INS, TPO
33testosterone44 59 11 2411.8IGF1, INS, ABCC8, PLAGL1, TPO
34arginine448.7KCNJ11, IGF1, INS, ABCC8, TPO
35cholesterol44 28 11 2411.4TPO, ABCC8, INS, IGF1

GO Terms for genes affiliated with Transient Neonatal Diabetes Mellitus

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16Gene Ontology
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Biological processes related to Transient Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycolysisGO:0458219.6INS, IGF1
2positive regulation of glycogen biosynthetic processGO:0457259.6IGF1, INS
3potassium ion transmembrane transportGO:0718059.5ABCC8, KCNJ11
4positive regulation of mitosisGO:0458409.5INS, IGF1
5positive regulation of DNA replicationGO:0457409.5INS, IGF1
6regulation of insulin secretionGO:0507969.5ABCC8, INS, KCNJ11
7energy reserve metabolic processGO:0061129.4ABCC8, INS, KCNJ11
8positive regulation of glucose importGO:0463269.4INS, IGF1

Molecular functions related to Transient Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:0051589.5INS, IGF1
2insulin-like growth factor receptor bindingGO:0051599.2INS, IGF1

Products for genes affiliated with Transient Neonatal Diabetes Mellitus

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  • Antibodies
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Sources for Transient Neonatal Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet