MCID: TRN018
MIFTS: 54

Transitional Cell Carcinoma malady

Rare diseases, Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Transitional Cell Carcinoma

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Transitional Cell Carcinoma, Aliases & Descriptions:

Name: Transitional Cell Carcinoma 9 41 11
Transitional Cell Carcinoma of Bladder 60
Carcinoma, Transitional Cell 60
Carcinoma Transitional Cell 43
 
Transitional Cell Neoplasm 60
Urothelial Cell Carcinoma 9
Transitional Cell Tumor 9
Transitional Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:2671
NCIt38 C4030, C2930
MeSH33 D002295

Summaries for Transitional Cell Carcinoma

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Wikipedia:63 Transitional cell carcinoma (TCC, also urothelial cell carcinoma or UCC) is a type of cancer that... more...

MalaCards based summary: Transitional Cell Carcinoma, also known as transitional cell carcinoma of bladder, is related to bladder transitional cell carcinoma and inverted papilloma. An important gene associated with Transitional Cell Carcinoma is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Transcriptional activation of cell cycle inhibitor p21 and GADD45 Pathway. The compounds topotecan and temozolomide have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and ovary, and related mouse phenotypes are pigmentation and hearing/vestibular/ear.

Disease Ontology:9 A carcinoma that derives from transitional epithelial cells.

Related Diseases for Transitional Cell Carcinoma

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Diseases related to Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma32.4TP53, IFI27
2inverted papilloma31.3IFI27, KRT13
3papilloma31.1TP53, IFI27, KRT13, CDKN1A
4bladder cancer, somatic30.9TP53, ERBB2, EGFR
5lung cancer30.5TP53, ERBB2, CDKN1A, EGFR
6colorectal cancer30.3FGF3, EGFR, CDKN1A, TP53
7endometrial cancer30.2TP53, IFI27, ERBB2, EGFR, FGF3
8retinoblastoma30.1TP53, IFI27, ERBB2, CDKN1A, EGFR, FGF3
9melanoma29.9TP53, IFI27, NOTCH1, CDKN1A, CGB, FGF3
10prostate cancer29.8PRSS8, IFI27, ERBB2, CDKN1A, EGFR, CGB
11adenoma29.8TP53, IFI27, NR2F1, KRT13, CDKN1A, CGB
12adenocarcinoma29.5IFI27, PRSS8, MMP10, TP53, ERBB2, KRT13
13prostatitis10.8
14invasive bladder transitional cell carcinoma10.6
15sarcomatoid transitional cell carcinoma10.6
16prostate transitional cell carcinoma10.5
17endotheliitis10.5
18renal cell carcinoma10.5
19urethritis10.5
20ovary transitional cell carcinoma10.5
21renal pelvis transitional cell carcinoma10.5
22tongue cancer10.5CDKN1A
23superior vena cava syndrome10.5CGB
24fallopian tube transitional cell carcinoma10.4
25bartholin's gland transitional cell carcinoma10.4
26ureter transitional cell carcinoma10.4
27horseshoe kidney10.4
28transitional cell carcinoma of the corpus uteri10.4
29giant cell glioblastoma10.4EGFR
30esophageal cancer10.4TP53, EGFR
31kidney pelvis sarcomatoid transitional cell carcinoma10.4
32urethra transitional cell carcinoma10.4
33endometrial transitional cell carcinoma10.4
34collecting duct carcinoma10.4
35urachal cyst10.4
36non-papillary transitional cell carcinoma of the bladder10.4
37biliary tract neoplasm10.4ERBB2, EGFR
38li-fraumeni syndrome10.4CDKN1A, TP53
39malignant mixed mullerian tumor10.4TP53, ERBB2
40inflammatory breast carcinoma10.4EGFR, ERBB2
41breast cancer10.4TP53, ERBB2, CDKN1A
42ductal carcinoma in situ10.3TP53, ERBB2, EGFR
43breast ductal carcinoma10.3TP53, ERBB2, EGFR
44stomach cancer10.3ERBB2, TP53
45infiltrating ureter transitional cell carcinoma10.3
46urethral diverticulum10.3
47papillary transitional carcinoma10.3
48ureterocele10.3
49leukemoid reaction10.3
50hydronephrosis10.3

Graphical network of the top 20 diseases related to Transitional Cell Carcinoma:



Diseases related to transitional cell carcinoma

Symptoms for Transitional Cell Carcinoma

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Drugs & Therapeutics for Transitional Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Transitional Cell Carcinoma

Search NIH Clinical Center for Transitional Cell Carcinoma

Genetic Tests for Transitional Cell Carcinoma

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Anatomical Context for Transitional Cell Carcinoma

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MalaCards organs/tissues related to Transitional Cell Carcinoma:

31
Kidney, Prostate, Ovary, Lymph node, Endothelial, Lung, Brain, Testes, Cervix, Bone, Breast, Testis, Monocytes, Bone marrow, Spinal cord, Heart, Colon, Adipocyte, Skin, Uterus, Dentritic cells, Neutrophil

Animal Models for Transitional Cell Carcinoma or affiliated genes

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Publications for Transitional Cell Carcinoma

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Articles related to Transitional Cell Carcinoma:

(show top 50)    (show all 1106)
idTitleAuthorsYear
1
Randomized phase III trial of piroxicam in combination with mitoxantrone or carboplatin for first-line treatment of urogenital tract transitional cell carcinoma in dogs. (25619518)
2015
2
Technical solutions to improve the management of non-muscle-invasive transitional cell carcinoma: summary of a European Association of Urology Section for Uro-Technology (ESUT) and Section for Uro-Oncology (ESOU) expert meeting and current and future perspectives. (25646531)
2015
3
Selective organ preservation with neo-adjuvant chemotherapy for the treatment of muscle invasive transitional cell carcinoma of the bladder. (25897675)
2015
4
Overexpression of flotillin-1 is involved in proliferation and recurrence of bladder transitional cell carcinoma. (24890092)
2014
5
Recurrent transitional cell carcinoma of the bladder: A mixed nested variant case report and literature review. (22511434)
2012
6
Surgical management for upper urinary tract transitional cell carcinoma (UUT-TCC): a systematic review. (22759317)
2012
7
Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor. (23018212)
2012
8
Prognostic significance of P27 (Kip 1) and MUC1 in papillary transitional cell carcinoma of the urinary bladder. (21346826)
2011
9
Ureterectomy and ureteral reimplatation for low-grade transitional cell carcinoma: is the laparoscopic approach feasible and effective? (21826883)
2011
10
Role of polysomy 17 in transitional cell carcinoma of the bladder: immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17. (19443884)
2009
11
Retroperitoneal lymph nodes in transitional cell carcinoma of the kidney and ureter. (19190765)
2009
12
Gemcitabine, paclitaxel, and cisplatin as combined adjuvant approach in transitional cell carcinoma of the urothelium. (19773726)
2009
13
Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. (19033864)
2009
14
Transitional cell carcinoma in renal transplant recipients: a single center experience. (18184173)
2008
15
Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207. (18272914)
2008
16
Upper urinary tract transitional cell carcinoma. A 10-year experience. (18468339)
2008
17
Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder. (17293658)
2007
18
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
19
Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. (15989448)
2005
20
Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. (16361539)
2005
21
A case of transitional cell carcinoma of the renal pelvis with adenocarcinoma producing CEA and CA19-9]. (15518131)
2004
22
Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. (15450303)
2004
23
Comparison of the nuclear matrix protein 22 with voided urine cytology in the diagnosis of transitional cell carcinoma of the bladder. (14685796)
2004
24
Differential expression of CD44 variant isoforms by cell lines and tissue specimens of transitional cell carcinomas. (14981907)
2003
25
Effect of intravesical treatment of transitional cell carcinoma with bacillus Calmette-Guerin and mitomycin C on urinary survivin levels and outcome. (12796695)
2003
26
Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. (12576464)
2003
27
Cathepsins B, H, and L activities in urine of patients with transitional cell carcinoma of the bladder. (11834417)
2002
28
p53 and bcl-2 overexpression as associated risk factors in patients 40 years old or less with transitional cell carcinoma of the bladder. (11464113)
2001
29
Urinary cytokeratin 20 as a marker for transitional cell carcinoma. (10765100)
2000
30
Correlative expression of glutathione S-transferase-pi and multidrug resistance associated protein in bladder transitional cell carcinoma. (12840920)
2000
31
Screening for transitional cell carcinoma of the bladder with trophoblastic differentiation in Upper Galilee]. (10909500)
1998
32
Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. (9818021)
1998
33
Invasion of the bladder by transitional cell carcinoma: its relation to histologic grade and expression of p53, MIB-1, c-erb B-2, epidermal growth factor receptor, and bcl-2. (9477105)
1998
34
Correlation of nuclear morphometry and immunostaining for p53 and proliferating cell nuclear antigen in transitional cell carcinoma of the bladder. (9477184)
1997
35
Flow cytometric evaluation of transferrin receptor in transitional cell carcinoma. (9373912)
1997
36
A hot spot for p53 mutation in transitional cell carcinoma of the bladder: clues to the etiology of bladder cancer. (9264274)
1997
37
Results at 43 months' follow-up of a double-blind, randomized, prospective clinical trial using intravesical interferon alpha-2b in the prophylaxis of stage pT1 transitional cell carcinoma of the bladder. (9037279)
1997
38
Detection and clinical pathological significance of the expression of P21, P185, p53 proteins and mutation of ras, p53 genes in transitional cell carcinoma of the bladder]. (9275651)
1996
39
Expression of CD44 splice variants in human transitional cell carcinoma. (8740026)
1996
40
Overexpression of C-erbB3 in transitional cell carcinoma of the ovary]. (8745489)
1995
41
Transitional cell carcinoma of the renal pelvis with choriocarcinomatous differentiation. Immunohistochemical and immunoelectron microscopic assessment of human chorionic gonadotropin production by transitional cell carcinoma of the urinary bladder. (8448745)
1993
42
The rat bladder tumor model system RBT resembles phenotypically and cytogenetically human superficial transitional cell carcinoma. (8171764)
1993
43
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
44
Primary localized amyloidosis of the renal pelvis coexisting with transitional cell carcinoma: a case report. (1632328)
1992
45
c-erbB-2 (HER-2/neu) oncopeptide immunoreactivity in localized, high-grade transitional cell carcinoma of the bladder. (1364264)
1992
46
Epidermal nevus with transitional cell carcinomas of the urinary tract. (1802914)
1991
47
Renal transitional cell carcinoma mimicking medullary sponge kidney. (2021801)
1991
48
ABO(H) antigens and beta-2 microglobulin in transitional cell carcinoma. Predictors of response to intravesical bacillus Calmette-Guerin. (1710534)
1991
49
Correlation of the expression of A, B isoantigens with its precursor H antigen in transitional cell carcinoma and the clinical signification of the expression]. (2086062)
1990
50
Nephrogenic adenoma in patients with transitional cell carcinoma of the bladder receiving intravesical thiotepa. (3121867)
1988

Variations for Transitional Cell Carcinoma

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Expression for genes affiliated with Transitional Cell Carcinoma

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Search GEO for disease gene expression data for Transitional Cell Carcinoma.

Pathways for genes affiliated with Transitional Cell Carcinoma

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Pathways related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0CDKN1A, TP53
210.0CDKN1A, TP53
3
Show member pathways
10.0CDKN1A, TP53
410.0EGFR, ERBB2
5
Show member pathways
AhR pathway36
10.0EGFR, CDKN1A
610.0EGFR, NOTCH1
7
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.8CDKN1A, ERBB2, TP53
8
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.8TP53, ERBB2, EGFR
99.8EGFR, ERBB2, TP53
10
Show member pathways
9.8TP53, ERBB2, EGFR
11
Show member pathways
9.8TP53, ERBB2, EGFR
12
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.8EGFR, CDKN1A, ERBB2
13
Show member pathways
9.8ERBB2, CDKN1A, EGFR
149.8EGFR, CDKN1A, TP53
159.8EGFR, CDKN1A, TP53
169.8TP53, CDKN1A, EGFR
179.8TP53, CDKN1A, EGFR
189.7RBX1, TP53
19
Show member pathways
9.6EGFR, CDKN1A, ERBB2, TP53
20
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.6EGFR, CDKN1A, ERBB2, TP53
219.6TP53, ERBB2, CDKN1A, EGFR
22
Show member pathways
Signal transduction PTEN pathway58
9.6TP53, ERBB2, CDKN1A, EGFR
239.6TP53, ERBB2, CDKN1A, EGFR
249.5TP53, RBX1, CDKN1A
25
Show member pathways
Cell cycle36
9.5TP53, RBX1, CDKN1A
26
Show member pathways
9.5TP53, ERBB2, EGFR, FGF3
27
Show member pathways
9.5FGF3, EGFR, CDKN1A, ERBB2
28
Show member pathways
9.5ERBB2, CDKN1A, EGFR, FGF3
29
Show member pathways
9.5ERBB2, CDKN1A, EGFR, FGF3
309.5TP53, CDKN1A, EGFR, FGF3
31
Show member pathways
9.5RBX1, NOTCH1, TP53
329.3TP53, ERBB2, NOTCH1, CDKN1A, EGFR
33
Show member pathways
9.3TP53, ERBB2, NOTCH1, CDKN1A, EGFR
34
Show member pathways
Signaling Pathways in Glioblastoma36
9.3TP53, ERBB2, CDKN1A, EGFR, FGF3
359.3FGF3, EGFR, CDKN1A, ERBB2, TP53
369.3ERBB2, RBX1, CDKN1A, EGFR
37
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.2TP53, NOTCH1, RBX1, EGFR
38
Show member pathways
9.0FGF3, EGFR, RBX1, ERBB2, TP53
39
Show member pathways
9.0FGF3, EGFR, CDKN1A, RBX1, ERBB2
40
Show member pathways
9.0ERBB2, RBX1, CDKN1A, EGFR, FGF3
418.8FGF3, EGFR, CDKN1A, RBX1, ERBB2, TP53
428.7ERBB2, NOTCH1, RBX1, CDKN1A, EGFR, FGF3
43
Show member pathways
8.6TP53, MMP10, ERBB2, NOTCH1, CDKN1A, EGFR
44
Show member pathways
8.5TP53, ERBB2, NOTCH1, RBX1, CDKN1A, EGFR

Compounds for genes affiliated with Transitional Cell Carcinoma

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Compounds related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1topotecan43 1211.5EGFR
2temozolomide43 1211.4CDKN1A, TP53
3hrgbeta14310.2EGFR, CDKN1A, ERBB2
4optimax4310.1CDKN1A, IFI27
5p000484310.1CDKN1A, IFI27
6n-(4-hydroxyphenyl)retinamide4310.1CDKN1A, ERBB2, TP53
7afatinib49 1211.0EGFR, ERBB2
8pd1587804310.0ERBB2, EGFR
9taxane4310.0TP53, ERBB2, CDKN1A, EGFR
10suberoylanilide hydroxamic acid4310.0TP53, ERBB2, CDKN1A, EGFR
11oxaliplatin43 49 1212.0EGFR, CDKN1A, ERBB2, TP53
12flavopiridol43 1211.0TP53, ERBB2, CDKN1A, EGFR
13bortezomib43 49 1212.0EGFR, CDKN1A, ERBB2, TP53
14irinotecan43 49 1212.0EGFR, CDKN1A, ERBB2, TP53
15leucovorin43 49 1212.0ERBB2, EGFR, CGB
16geldanamycin43 49 59 1213.0TP53, ERBB2, CDKN1A, EGFR
17gemcitabine43 49 1212.0EGFR, CDKN1A, ERBB2, TP53
18hmba439.9CDKN1A, IFI27, TP53
19ag 1478 hydrochloride599.9ERBB2, EGFR
20docetaxel43 49 59 1212.9TP53, ERBB2, CDKN1A, EGFR
21batimastat43 59 1211.9MMP10, ERBB2, EGFR
22egcg439.9TP53, ERBB2, CDKN1A, EGFR
23curcumin439.9TP53, ERBB2, CDKN1A, EGFR
24indole-3-carbinol439.9TP53, IFI27, CDKN1A
25sulindac43 1210.9CDKN1A, IFI27, TP53
265fluorouracil439.8EGFR, CDKN1A, ERBB2, TP53
27roscovitine439.7TP53, IFI27, CDKN1A
28gefitinib43 49 1211.7IFI27, ERBB2, CDKN1A, EGFR
29iressa599.7ERBB2, EGFR
30resveratrol43 59 24 1212.7TP53, IFI27, ERBB2, CDKN1A
31adpribose439.7EGFR, CDKN1A, IFI27, TP53
32mg 13243 5910.7EGFR, CDKN1A, IFI27, TP53
33agar439.6FGF3, EGFR, CDKN1A, ERBB2
34thymidylate439.6TP53, IFI27, ERBB2, CDKN1A, EGFR
35n acetylcysteine439.5TP53, IFI27, ERBB2, CDKN1A, EGFR
36tamoxifen43 49 28 1212.5TP53, IFI27, ERBB2, CDKN1A, EGFR
37paclitaxel43 49 1211.5TP53, IFI27, ERBB2, CDKN1A, EGFR
38rapamycin439.5IFI27, ERBB2, NOTCH1, CDKN1A, EGFR
39genistein43 28 59 2 24 1214.4IFI27, ERBB2, NOTCH1, CDKN1A, EGFR
40retinoid439.4TP53, IFI27, CDKN1A, EGFR
41ly294002439.3TP53, IFI27, ERBB2, NOTCH1, CDKN1A, EGFR
42doxorubicin43 49 1211.3TP53, IFI27, ERBB2, NOTCH1, CDKN1A, EGFR
43cisplatin43 49 59 1212.2TP53, IFI27, ERBB2, CDKN1A, EGFR, CGB
44paraffin439.1TP53, IFI27, ERBB2, KRT13, CDKN1A, EGFR
45progesterone43 28 59 24 1213.0TP53, IFI27, NR2F1, ERBB2, CDKN1A, EGFR
46serine438.7TP53, MMP10, PRSS8, ERBB2, NOTCH1, CDKN1A
47estrogen438.7TP53, IFI27, NR2F1, ERBB2, NOTCH1, CDKN1A
48vegf438.4FGF3, TP53, MMP10, IFI27, ERBB2, NOTCH1
49oligonucleotide438.2MZF1, TP53, MMP10, IFI27, NR2F1, CDKN1A
50retinoic acid43 249.0MZF1, TP53, IFI27, NR2F1, KRT13, NOTCH1

GO Terms for genes affiliated with Transitional Cell Carcinoma

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Cellular components related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:00432359.5EGFR, NOTCH1, ERBB2
2nucleoplasmGO:00056548.9CDKN1A, RBX1, NOTCH1, NR2F1, TP53

Biological processes related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:007185010.2CDKN1A, TP53
2intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:004277110.0CDKN1A, TP53
3positive regulation of epithelial cell proliferationGO:005067910.0EGFR, NOTCH1, ERBB2
4cellular response to ionizing radiationGO:00714799.9CDKN1A, TP53
5cell cycle arrestGO:00070509.8CDKN1A, HEPACAM, TP53
6phosphatidylinositol-mediated signalingGO:00480159.8FGF3, EGFR, CDKN1A, ERBB2
7fibroblast growth factor receptor signaling pathwayGO:00085439.7ERBB2, CDKN1A, EGFR, FGF3
8Fc-epsilon receptor signaling pathwayGO:00380959.7ERBB2, CDKN1A, EGFR, FGF3
9positive regulation of reactive oxygen species metabolic processGO:020003799.7CDKN1A, TP53
10epidermal growth factor receptor signaling pathwayGO:00071739.7ERBB2, CDKN1A, EGFR, FGF3
11neurotrophin TRK receptor signaling pathwayGO:00480119.7ERBB2, CDKN1A, EGFR, FGF3
12Notch signaling pathwayGO:00072199.6TP53, NOTCH1, RBX1
13signal transductionGO:00071659.1NR2F1, ERBB2, EGFR, CGB, FGF3

Molecular functions related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:000500610.1EGFR, ERBB2
2transmembrane receptor protein tyrosine kinase activityGO:000471410.0EGFR, ERBB2
3receptor signaling protein tyrosine kinase activityGO:00047169.9ERBB2, EGFR
4protein phosphatase bindingGO:00199039.8EGFR, ERBB2, TP53
5protein bindingGO:00055156.7MZF1, TP53, PRSS8, NR2F1, ERBB2, NOTCH1

Products for genes affiliated with Transitional Cell Carcinoma

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Sources for Transitional Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet