MCID: TRN018
MIFTS: 64

Transitional Cell Carcinoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Transitional Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Transitional cell carcinoma (TCC, also urothelial cell carcinoma or UCC) is a type of cancer that... more...

MalaCards: Transitional Cell Carcinoma, also known as transitional cell neoplasm, is related to bladder transitional cell carcinoma and bladder carcinoma. An important gene associated with Transitional Cell Carcinoma is PTCH1 (patched 1), and among its related pathways are Pathways in cancer and Proteoglycans in cancer. The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and ovary, and related mouse phenotypes are mortality/aging and growth/size.

Disease Ontology:8 A carcinoma that derives from transitional epithelial cells.

Aliases & Classifications for Transitional Cell Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

transitional cell carcinoma 8 42 10
transitional cell neoplasm 8 60
transitional cell carcinoma of the urinary tract 8
transitional cell carcinoma nos 8
carcinoma, transitional cell 60
carcinoma transitional cell 44
transitional cell tumor 8
transitional carcinoma 8


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Disease Ontology8 DOID:2671
NCIt39 C2930, C4030
MeSH34 D002295

Related Diseases for Transitional Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma32.1IFI27, FABP4, FABP12, CDH1, TP53
2bladder carcinoma32.1CDH1, CDKN1A, ERBB2, TP53
3papillary carcinoma31.0ERBB2, CDH1, IFI27
4adenocarcinoma30.9IFI27, EGFR, CDH1, CDKN1A, KRT13, PTCH1
5papilloma30.9TP53, KRT13, CDKN1A, IFI27
6inverted papilloma30.8KRT13, IFI27
7squamous cell carcinoma30.7IFI27, FABP5, EGFR, CDH1, CDKN1A, FGF3
8bladder carcinoma in situ30.7UPK2, EGFR, BLCAP, CDH1, ERBB2, TP53
9adenoma30.4IFI27, NR2F1, CDH1, CDKN1A, FGF3, KRT13
10prostate cancer30.3IFI27, EGFR, CDH1, CDKN1A, ERBB2
11cystitis30.3UPK1A, UPK2
12endometrial carcinoma30.3CDH1, ERBB2, TP53
13osteosarcoma30.3TP53, CDKN1A
14retinoblastoma30.0IFI27, EGFR, CDKN1A, FGF3, ERBB2, TP53
15melanoma30.0IFI27, CDH1, CDKN1A, FGF3, BIRC7, PTCH1
16lung adenocarcinoma30.0TP53, ERBB2, CDKN1A, CDH1, EGFR
17lung cancer30.0TP53, ERBB2, CDKN1A, CDH1, EGFR
18colon cancer30.0EGFR, CDH1, CDKN1A, FGF3, TP53
19renal cell carcinoma11.0
20invasive bladder transitional cell carcinoma10.9
21renal pelvis transitional cell carcinoma10.9
22renal pelvis carcinoma10.9
23ureter transitional cell carcinoma10.8
24prostate transitional cell carcinoma10.7
25prostatitis10.7
26ovary transitional cell carcinoma10.7
27papillary transitional carcinoma10.7
28in situ carcinoma10.6
29transitional papilloma10.6
30inverted transitional papilloma10.5
31sarcomatoid transitional cell carcinoma10.5
32urethra transitional cell carcinoma10.5
33bladder disease10.5
34urethritis10.5
35fallopian tube transitional cell carcinoma10.5
36bladder transitional cell papilloma10.5
37endometrial transitional cell carcinoma10.4
38collecting duct carcinoma10.3
39small cell carcinoma10.3
40renal pelvis adenocarcinoma10.3
41bladder squamous cell carcinoma10.3
42prostate adenocarcinoma10.3
43transitional cell carcinoma of the corpus uteri10.3
44bone carcinoma10.3
45hydronephrosis10.3
46urethral diverticulum10.3
47kidney pelvis sarcomatoid transitional cell carcinoma10.3
48ureterocele10.3
49bladder urothelial papillary carcinoma10.3
50bladder adenocarcinoma10.3

Graphical network of the top 20 diseases related to Transitional Cell Carcinoma:



Diseases related to transitional cell carcinoma

Clinical Features for Transitional Cell Carcinoma

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Drugs & Therapeutics for Transitional Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Transitional Cell Carcinoma

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Genetic Tests for Transitional Cell Carcinoma

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Anatomical Context for Transitional Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Transitional Cell Carcinoma:

32
Kidney, Prostate, Ovary, Endothelial, Lung, Lymph node, Breast, Testes, Cervix, Bone, Brain, Colon, Testis, Smooth muscle, T cells, Monocytes, Thyroid, Adipocyte, Heart, Bone marrow, Spinal cord, Tongue, Dentritic cells

Animal Models for Transitional Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Transitional Cell Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.8FABP5, FABP4, UPK2, EGFR, MZF1, NR2F1
2MP:000537811.5FABP5, FABP4, UPK2, EGFR, CDH1, CDKN1A
3MP:000301211.5TP53, HEPACAM, EGFR, NR2F1, CDH1, CDKN1A
4MP:000200611.3EGFR, MZF1, CDH1, CDKN1A, PTCH1, ERBB2
5MP:000538511.3FABP5, FABP4, EGFR, CDH1, CDKN1A, PTCH1
6MP:000536911.1FABP5, FABP4, CDKN1A, PTCH1, TP53
7MP:000537510.9TP53, CDKN1A, EGFR, FABP4, FABP5
8MP:000539010.8MZF1, CDKN1A, FGF3, PTCH1
9MP:000538010.8EGFR, CDH1, CDKN1A, FGF3, PTCH1, ERBB2
10MP:001077110.8TP53, PTCH1, CDKN1A, CDH1
11MP:000537110.7FGF3

Publications for Transitional Cell Carcinoma

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50PubMed
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Articles related to Transitional Cell Carcinoma:

(show top 50)    (show all 1235)
idTitleAuthorsYear
1
miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). (23212913)
2013
2
Advanced Neuroimaging Studies in a Patient with Brain Metastases from Transitional Cell Carcinoma of the Bladder. (23551927)
2013
3
Surgical management for upper urinary tract transitional cell carcinoma (UUT-TCC): a systematic review. (22759317)
2012
4
Metastatic bladder transitional cell carcinoma presenting as a vascularised cutaneous right arm lesion. (21779951)
2012
5
Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder. (21396841)
2012
6
Prognostic significance of P27 (Kip 1) and MUC1 in papillary transitional cell carcinoma of the urinary bladder. (21346826)
2011
7
Transitional cell carcinoma of the native urinary tract after kidney transplantation: recommendations following a long-term retrospective analysis. (21412138)
2011
8
Bone morphogenetic protein-4-induced epithelial-mesenchymal transition and invasiveness through Smad1-mediated signal pathway in squamous cell carcinoma of the head and neck. (21565626)
2011
9
Prognostic factors influencing survival after nephroureterectomy for transitional cell carcinoma of the upper urinary tract. (21525971)
2011
10
Transitional cell carcinoma of the bladder: racial and gender disparities in survival (1993 to 2002), stage and grade (1993 to 2007). (21419456)
2011
11
Palmar fasciitis and polyarthritis syndrome associated with transitional cell carcinoma of the bladder. (20638154)
2011
12
A rare cause of scrotal swelling: transitional cell carcinoma of the bladder presenting as a testicular metastasis. (21603207)
2011
13
Potentiation of mitomycin C tumoricidal activity for transitional cell carcinoma by histone deacetylase inhibitors in vitro. (22019171)
2011
14
Transitional cell carcinoma of the bladder in children and adolescents: six-case series and review of the literature. (20080447)
2010
15
Shotgun proteome expression profile of microdissected superficial transitional cell carcinoma and biomarker discovery from urine. (21475891)
2009
16
High-grade transitional cell carcinoma and melanosis of urinary bladder: case report and review of the literature. (19056107)
2009
17
Comparison of open nephroureterectomy and open conservative management of upper urinary tract transitional cell carcinoma. (19440024)
2009
18
Incidental diagnosis of transitional cell carcinoma during percutaneous nephrolithotomy. (19829028)
2009
19
Enterocolitis related to chemotherapy with gemcitabine and cisplatin in patient with transitional cell carcinoma of ureter. (19686356)
2009
20
Genetic association of monocyte chemoattractant protein 1 (MCP-1)-2518 polymorphism in Mexican patients with transitional cell carcinoma of the bladder. (19646633)
2009
21
LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells. (19724917)
2009
22
Clinical significance of lymph node dissection in patients with muscle-invasive upper urinary tract transitional cell carcinoma treated with nephroureterectomy. (19654951)
2009
23
Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma. (18257856)
2008
24
E-cadherin tissue expression and urinary soluble forms of E-cadherin in patients with bladder transitional cell carcinoma. (18931551)
2008
25
Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 cases. (18379419)
2008
26
Prognostic factors for upper tract transitional cell carcinoma: a retrospective review of 66 patients. (18334465)
2008
27
Combined assay of CYFRA21-1, telomerase and vascular endothelial growth factor in the detection of bladder transitional cell carcinoma. (17302565)
2007
28
Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder. (17164231)
2007
29
Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. (16899764)
2006
30
Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells. (15947580)
2005
31
Does human papillomavirus play a role in the development of bladder transitional cell carcinoma? A comparison of PCR and immunohistochemical analysis. (15677544)
2005
32
Expression of MUC1 and distribution of tumor-infiltrating dentritic cells in human bladder transitional cell carcinoma]. (16174576)
2005
33
Estrogen receptor expression in papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma. (15679420)
2005
34
The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder. (15886698)
2005
35
Combined effects of p53, p21, and pRb expression in the progression of bladder transitional cell carcinoma. (14981105)
2004
36
Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder. (14633685)
2003
37
Organ-sparing treatment of invasive transitional cell bladder carcinoma. (17918795)
2002
38
Impaired alpha-interferon signaling in transitional cell carcinoma: lack of p48 expression in 5637 cells. (11280796)
2001
39
Relevance of p53 gene alterations for tumor recurrence in patients with superficial transitional cell carcinoma of the bladder. (11223675)
2001
40
Brenner tumor of the ovary: a comparative immunohistochemical and ultrastructural study with transitional cell carcinoma of the bladder. (10914427)
2000
41
Re: Initial evaluation of CYFRA 21-1 diagnostic performances as a urinary marker in bladder transitional cell carcinoma. (9720567)
1998
42
Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas. (9018118)
1997
43
Primary renal epithelioid angiosarcoma with transitional cell carcinoma in renal pelvis]. (10374567)
1997
44
Detection and clinical pathological significance of the expression of P21, P185, p53 proteins and mutation of ras, p53 genes in transitional cell carcinoma of the bladder]. (9275651)
1996
45
Cytokeratin 20 expression by non-invasive transitional cell carcinomas: potential for distinguishing recurrent from non-recurrent disease. (8835265)
1995
46
Transitional cell carcinoma with adeno-squamous carcinoma component of renal pelvis in horseshoe kidney: a case report. (2239612)
1990
47
Transitional cell carcinoma in the Muir-Torre syndrome. (3599263)
1987
48
Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells. (3003159)
1986
49
Simultaneous occurrence of transitional cell carcinoma and urothelial adenocarcinoma associated with xanthogranulomatous pyelonephritis. (4049622)
1985
50
Transitional cell carcinoma in a urethral diverticulum with a calculus. (6403714)
1983

Genetic Variations for Transitional Cell Carcinoma

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Expression for genes affiliated with Transitional Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transitional Cell Carcinoma

Search GEO for disease gene expression data for Transitional Cell Carcinoma.

Pathways for genes affiliated with Transitional Cell Carcinoma

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Sources:
29KEGG, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems, 55SinoBiological, 53Reactome, 59Tocris Bioscience
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Pathways related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2TP53, EGFR, CDH1, CDKN1A, FGF3, BIRC7
211.0EGFR, CDKN1A, FGF3, PTCH1, ERBB2, TP53
3
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10.9EGFR, CDH1, CDKN1A, ERBB2, TP53
4
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10.9EGFR, CDH1, FGF3, ERBB2, TP53
510.9EGFR, CDKN1A, ERBB2, TP53
6
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10.9EGFR, CDKN1A, ERBB2, TP53
710.9TP53, ERBB2, CDKN1A, EGFR
810.9TP53, ERBB2, CDKN1A, EGFR
9
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10.9EGFR, CDKN1A, ERBB2, TP53
10
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10.8TP53, ERBB2, CDH1, EGFR
1110.8EGFR, CDH1, ERBB2, TP53
12
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10.8EGFR, CDKN1A, FGF3, ERBB2
13
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10.8EGFR, CDKN1A, FGF3, ERBB2
14
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10.8EGFR, CDKN1A, FGF3, ERBB2
15
Transcription Androgen Receptor nuclear signaling
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10.8ERBB2, CDKN1A, EGFR
1610.8ERBB2, CDKN1A, EGFR
1710.8EGFR, CDKN1A, TP53
1810.8ERBB2, CDH1, EGFR
19
Hide members
10.8TP53, FGF3, CDKN1A
20
Apoptosis and survival Apoptotic TNF-family pathways
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10.8CDKN1A, BIRC7, TP53
21
Hide members
10.7TP53, ERBB2
2210.7ERBB2, EGFR
2310.6EGFR

Compounds for genes affiliated with Transitional Cell Carcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.9TP53, IFI27, FABP5, FABP4, FABP12, EGFR
2paraffin4411.7IFI27, EGFR, CDH1, CDKN1A, KRT13, PTCH1
3retinoid4411.6IFI27, FABP4, FABP12, EGFR, CDH1, CDKN1A
4doxorubicin44 49 1113.6IFI27, EGFR, CDH1, CDKN1A, BIRC7, ERBB2
5cisplatin44 49 59 1114.5IFI27, EGFR, CDH1, CDKN1A, BIRC7, ERBB2
6progesterone44 59 28 11 2415.5IFI27, EGFR, NR2F1, CDH1, CDKN1A, ERBB2
7thymidylate4411.5IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
8oligonucleotide4411.5IFI27, FABP4, MZF1, NR2F1, CDKN1A, FGF3
9troglitazone44 28 59 1114.5IFI27, FABP4, UPK2, CDH1, CDKN1A, KRT13
105fluorouracil4411.5EGFR, CDH1, CDKN1A, BIRC7, ERBB2, TP53
11vegf4411.5IFI27, EGFR, CDH1, CDKN1A, FGF3, ERBB2
12n acetylcysteine4411.5IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
13tamoxifen44 49 28 1114.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
14paclitaxel44 49 1113.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
15ly2940024411.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
16suberoylanilide hydroxamic acid4411.4EGFR, CDH1, CDKN1A, ERBB2, TP53
17irinotecan44 49 1113.4EGFR, CDH1, CDKN1A, ERBB2, TP53
18gefitinib44 49 1113.4IFI27, EGFR, CDH1, CDKN1A, ERBB2
19geldanamycin44 49 59 1114.4EGFR, CDH1, CDKN1A, ERBB2, TP53
20docetaxel44 49 59 1114.3EGFR, CDH1, CDKN1A, ERBB2, TP53
21mg 13244 5912.3IFI27, EGFR, CDH1, CDKN1A, TP53
22curcumin4411.3EGFR, CDH1, CDKN1A, ERBB2, TP53
23taxane4411.3TP53, ERBB2, CDKN1A, EGFR
24agar4411.3EGFR, CDH1, CDKN1A, FGF3, ERBB2
25indole-3-carbinol4411.3TP53, CDKN1A, CDH1, IFI27
26sulindac44 1112.2IFI27, CDH1, CDKN1A, TP53
27oxaliplatin44 49 1113.2TP53, ERBB2, CDKN1A, EGFR
28vitamin d4411.2ERBB2, KRT13, CDKN1A, CDH1, IFI27
29flavopiridol44 1112.2TP53, ERBB2, CDKN1A, EGFR
30celecoxib44 59 28 49 11 2416.2EGFR, CDH1, CDKN1A, ERBB2
31bortezomib44 1112.2TP53, ERBB2, CDKN1A, EGFR
32rapamycin4411.2IFI27, EGFR, CDH1, CDKN1A, ERBB2
33adpribose4411.2IFI27, EGFR, CDKN1A, TP53
34pki-1664411.2EGFR, CDH1, ERBB2
35hrgbeta14411.2EGFR, CDKN1A, ERBB2
36gemcitabine44 49 1113.2TP53, ERBB2, CDKN1A, EGFR
37resveratrol44 59 11 2414.1IFI27, CDKN1A, ERBB2, TP53
38etoposide44 49 59 1114.1CDH1, BIRC7, ERBB2
39temozolomide44 1112.0EGFR, CDKN1A, TP53
40steroid4411.0ERBB2, FGF3, FABP4, FABP5, IFI27
4117-(allylamino)-17-demethoxygeldanamycin4410.9CDH1, CDKN1A, ERBB2
42p000484410.9CDKN1A, IFI27
43genistein44 28 59 2 11 2415.8IFI27, EGFR, CDH1, CDKN1A, ERBB2
44optimax4410.8CDKN1A, IFI27
45adriamycin4410.8CDKN1A
46estrogen4410.8NR2F1
47erlotinib44 49 1112.8ERBB2, CDH1, EGFR
48Afatinib1110.7EGFR, ERBB2
49depsipeptide4410.7TP53, CDH1
50topotecan44 1111.5TP53, ERBB2, EGFR

GO Terms for genes affiliated with Transitional Cell Carcinoma

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16Gene Ontology
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Biological processes related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801511.0ERBB2, FGF3, CDKN1A, EGFR
2fibroblast growth factor receptor signaling pathwayGO:00854311.0EGFR, CDKN1A, FGF3, ERBB2
3Fc-epsilon receptor signaling pathwayGO:03809511.0ERBB2, FGF3, CDKN1A, EGFR
4epidermal growth factor receptor signaling pathwayGO:00717310.9EGFR, CDKN1A, FGF3, ERBB2
5mitotic cell cycle arrestGO:07185010.7TP53, CDKN1A
6cellular response to lithium ionGO:07128510.7CDH1, FABP4
7epidermis developmentGO:00854410.7FABP5, KRT13, PTCH1
8neurotrophin TRK receptor signaling pathwayGO:04801110.5ERBB2, FGF3, CDKN1A, EGFR

Molecular functions related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.7ERBB2, EGFR
2cyclin bindingGO:03033210.7PTCH1, CDKN1A
3protein phosphatase bindingGO:01990310.7ERBB2, CDH1, EGFR
4receptor signaling protein tyrosine kinase activityGO:00471610.4ERBB2, EGFR

Products for genes affiliated with Transitional Cell Carcinoma

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  • Antibodies
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Sources for Transitional Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet