MCID: TRN018
MIFTS: 61

Transitional Cell Carcinoma malady

Nephrological, Cancer categories

Summaries for Transitional Cell Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Transitional cell carcinoma (TCC, also urothelial cell carcinoma or UCC) is a type of cancer that... more...

MalaCards: Transitional Cell Carcinoma, also known as transitional cell neoplasm, is related to bladder transitional cell carcinoma and bladder carcinoma. An important gene associated with Transitional Cell Carcinoma is PTCH1 (patched 1), and among its related pathways are Pathways in cancer and Proteoglycans in cancer. The compounds retinoic acid and paraffin have been mentioned in the context of this disorder. Affiliated tissues include ovary, spinal cord and brain, and related mouse phenotypes are mortality/aging and growth/size.

Disease Ontology:8 A carcinoma that derives from transitional epithelial cells.

Aliases & Classifications for Transitional Cell Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 45Novoseek, 40NCIt, 35MeSH, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological


Aliases & Descriptions:

transitional cell carcinoma 8 43 10
transitional cell neoplasm 8 61
transitional cell carcinoma of the urinary tract 8
transitional cell carcinoma nos 8
carcinoma, transitional cell 61
carcinoma transitional cell 45
transitional cell tumor 8
transitional carcinoma 8


External Ids:

Disease Ontology8 DOID:2671
NCIt40 C2930, C4030
MeSH35 D002295

Related Diseases for Transitional Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma32.2IFI27, CDH1, FABP4, FABP12, TP53
2bladder carcinoma32.2TP53, CDH1, CDKN1A, ERBB2
3papillary carcinoma31.0ERBB2, IFI27, CDH1
4adenocarcinoma30.9ERBB2, EGFR, KRT13, IFI27, PTCH1, CDH1
5squamous cell carcinoma30.8TP53, ERBB2, CDH1, KRT13, FGF3, CDKN1A
6adenoma30.4IFI27, NR2F1, CDKN1A, FGF3, KRT13, CDH1
7bladder carcinoma in situ30.1CDH1, TP53, UPK2, EGFR, BLCAP, ERBB2
8ureter transitional cell carcinoma10.9
9prostate transitional cell carcinoma10.7
10papillary transitional carcinoma10.7
11ovary transitional cell carcinoma10.7
12transitional papilloma10.7
13urethra transitional cell carcinoma10.6
14bladder transitional cell papilloma10.6
15inverted transitional papilloma10.6
16sarcomatoid transitional cell carcinoma10.6
17bladder disease10.5
18fallopian tube transitional cell carcinoma10.5
19endometrial transitional cell carcinoma10.4
20horseshoe kidney10.4
21collecting duct carcinoma10.4
22small cell carcinoma10.4
23renal pelvis adenocarcinoma10.4
24bladder squamous cell carcinoma10.4
25urachal cyst10.4
26transitional cell carcinoma of the corpus uteri10.4
27bone carcinoma10.3
28hydronephrosis10.3
29urethral diverticulum10.3
30kidney pelvis sarcomatoid transitional cell carcinoma10.3
31ureterocele10.3
32bladder sarcoma10.3
33bladder urothelial papillary carcinoma10.3
34bladder adenocarcinoma10.3
35bladder diverticulum10.3
36invasive mole10.3
37urinary tract non-invasive transitional cell neoplasm10.2
38bladder papillary transitional cell neoplasm10.2
39nephrogenic adenoma10.2
40ovarian brenner tumor10.2
41leukemoid reaction10.2
42acanthosis nigricans10.2
43xanthogranulomatous pyelonephritis10.2
44lambert-eaton myasthenic syndrome10.2
45clear cell adenocarcinoma10.2
46sarcomatoid renal cell carcinoma10.2
47muir-torre syndrome10.2
48infiltrating ureter transitional cell carcinoma10.2
49breast papillary carcinoma10.2
50anal canal carcinoma10.2

Graphical network of the top 20 diseases related to Transitional Cell Carcinoma:



Diseases related to transitional cell carcinoma

Clinical Features for Transitional Cell Carcinoma

Drugs & Therapeutics for Transitional Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Transitional Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Transitional Cell Carcinoma

Search NIH Clinical Center for Transitional Cell Carcinoma

Search CenterWatch for Transitional Cell Carcinoma

Genetic Tests for Transitional Cell Carcinoma

Anatomical Context for Transitional Cell Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Transitional Cell Carcinoma:

33
Ovary, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Heart, Colon, Adipocyte, Breast, Prostate, Testis, Cervix, Monocytes, Dentritic cells, T cells, B cells, Endothelial

Animal Models for Transitional Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Transitional Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Transitional Cell Carcinoma:

(show top 50)    (show all 1115)
idTitleAuthorsYear
1
Randomized trial of cisplatin versus firocoxib versus cisplatin/firocoxib in dogs with transitional cell carcinoma of the urinary bladder. (23205923)
2013
2
Lack of association between HLA-E polymorphisms and transitional cell carcinoma of the bladder. (23786553)
2013
3
Transitional Cell Carcinoma of the Retrorectal Space Arisen in Tailgut Cyst: A Case Report and Review of the Literature. (23816825)
2013
4
Redox- and expression-proteomic analysis of plasma biomarkers in bladder transitional cell carcinoma. (23090237)
2012
5
Metastatic bladder transitional cell carcinoma presenting as a vascularised cutaneous right arm lesion. (21779951)
2012
6
Gigantic transitional cell carcinoma of the renal pelvis in the region of endemic nephropathy. (23654018)
2012
7
Accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC) as neoadjuvant chemotherapy for patients with muscle-invasive transitional cell carcinoma of the bladder. (22614698)
2012
8
Radiotherapy may improve overall survival of patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter and delay bladder tumour relapse. (21756352)
2011
9
Transitional cell carcinoma of the ovary. (22036142)
2011
10
Immunohistochemical detection of cyclin E in transitional cell carcinoma. (22331729)
2011
11
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. (21822268)
2011
12
Serum Th1 and Th2 cytokine balance in patients of superficial transitional cell carcinoma of bladder pre- and post-intravesical combination immunotherapy. (20105083)
2010
13
Submucosal ureteric calculus mimicking transitional cell carcinoma. (20089036)
2010
14
Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. (20582552)
2010
15
Circumcaval ureter with a synchronous ipsilateral transitional cell carcinoma of the upper urinary tract and the urinary bladder. (20517835)
2010
16
Retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision for native upper tract transitional cell carcinoma ipsilateral to a transplanted kidney. (20430425)
2010
17
SOX2 modulates alternative splicing in transitional cell carcinoma. (20138825)
2010
18
Noninvasive transitional cell carcinoma is associated with a high occurrence of false positives in photodynamic diagnosis. (19660856)
2009
19
Transitional cell carcinoma of the urinary tract in renal transplant recipients. (19404862)
2009
20
Ureteric frozen sections during radical cystectomy for transitional cell carcinoma of the bladder--to do or not to do? (19154453)
2009
21
Transitional cell metaplasia of fallopian tube fimbriae: a potential mimic of early tubal carcinoma in risk reduction salpingo-oophorectomies from women With BRCA mutations. (18830124)
2009
22
Management of early-invasive high-grade transitional cell carcinoma of the bladder. (18923363)
2008
23
Presentation, location and overall survival of pelvic recurrence after radical cystectomy for transitional cell carcinoma of the bladder. (18005201)
2008
24
Prognostic factors for upper tract transitional cell carcinoma: a retrospective review of 66 patients. (18334465)
2008
25
Minimally invasive management of upper tract malignancies: renal cell and transitional cell carcinoma. (18761193)
2008
26
Significance of muscularis mucosae in metastasis involvement of urinary bladder transitional cell carcinoma. (17100383)
2006
27
BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder. (16484005)
2006
28
The prognostic value of p53, Ki-67 and matrix metalloproteinases MMP-2 and MMP-9 in transitional cell carcinoma of the renal pelvis and ureter. (16351648)
2005
29
Micro-array analysis of the effect of post-transurethral bladder tumor resection urine on transforming growth factor-beta1 dependent gene expression in transitional cell carcinoma. (16301119)
2005
30
Bacillus Calmette-Guerin initiates intracellular signaling in a transitional carcinoma cell line by cross-linking alpha 5 beta 1 integrin. (12853840)
2003
31
Expression of matrix metalloproteinases in human transitional cell carcinoma of the urinary bladder. (12579270)
2003
32
Prognostic significance of hepatoma-up-regulated protein expression in patients with urinary bladder transitional cell carcinoma. (12894566)
2003
33
The expression of p53 and c-erb-2 in transitional cell carcinoma of the kidney pelvis and ureter and its relation to tumor progression and survival]. (12380307)
2002
34
Prognostic significance of proliferating cell nuclear antigen expression in transitional cell carcinoma of the upper urinary tract. (9252716)
1997
35
Use of p53 in the diagnosis of upper-tract transitional cell carcinoma. (9037278)
1997
36
Grading of upper urinary tract transitional cell carcinoma by computed DNA content and p53 expression. (9426716)
1997
37
Telomerase activity: a potential marker of bladder transitional cell carcinoma in bladder washes. (9259615)
1997
38
Therapy of human transitional cell carcinoma of the bladder by oral administration of the epidermal growth factor receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide. (9815668)
1997
39
Detection and clinical pathological significance of the expression of P21, P185, p53 proteins and mutation of ras, p53 genes in transitional cell carcinoma of the bladder]. (9275651)
1996
40
The significance of E-cadherin in transitional-cell carcinoma of the human urinary bladder. (8738404)
1996
41
Combined small cell and transitional cell carcinoma of renal pelvis: a case report]. (7900568)
1995
42
P53 expression, ploidy and progression in pT1 transitional cell carcinoma of the bladder. (8012776)
1994
43
Treatment of transitional cell carcinoma of the bladder with intravesical interleukin-2: a pilot study. (7804362)
1993
44
Epidermal growth factor receptor-mediated autocrine and paracrine stimulation of human transitional cell carcinoma. (8221665)
1993
45
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
46
Transitional cell carcinoma in a urethral diverticulum. (1586346)
1992
47
Renal transitional cell carcinoma mimicking medullary sponge kidney. (2021801)
1991
48
Selective and non-selective loss of immunoregulatory molecules (HLA-A,B,C antigens and LFA-3) in transitional cell carcinoma. (1699592)
1990
49
Miliary tuberculosis secondary to transurethral bacillus Calmette-GuAcrin administration for superficial transitional cell carcinoma of the bladder. (2362292)
1990
50
Ultrastructural localization of c-erbB-2 gene product in transitional cell carcinoma of the urinary tract. (1978950)
1990

Genetic Variations for Transitional Cell Carcinoma

Expression for genes affiliated with Transitional Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Transitional Cell Carcinoma

Search GEO for disease gene expression data for Transitional Cell Carcinoma.

Pathways for genes affiliated with Transitional Cell Carcinoma

Sources:
30KEGG, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 50PharmGKB, 53R&D Systems, 56SinoBiological, 54Reactome, 60Tocris Bioscience
See all sources

Pathways related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2TP53, EGFR, CDH1, CDKN1A, FGF3, BIRC7
211.0EGFR, CDKN1A, FGF3, PTCH1, ERBB2, TP53
3
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10.9EGFR, CDH1, CDKN1A, ERBB2, TP53
4
Hide members
10.9EGFR, CDH1, FGF3, ERBB2, TP53
510.9EGFR, CDKN1A, ERBB2, TP53
6
Hide members
10.9EGFR, CDKN1A, ERBB2, TP53
710.9TP53, ERBB2, CDKN1A, EGFR
810.9TP53, ERBB2, CDKN1A, EGFR
9
Hide members
10.9EGFR, CDKN1A, ERBB2, TP53
10
Hide members
10.8TP53, ERBB2, CDH1, EGFR
1110.8EGFR, CDH1, ERBB2, TP53
12
Hide members
10.8EGFR, CDKN1A, FGF3, ERBB2
13
Hide members
10.8EGFR, CDKN1A, FGF3, ERBB2
14
Hide members
10.8EGFR, CDKN1A, FGF3, ERBB2
15
Transcription Androgen Receptor nuclear signaling
Hide members
10.8ERBB2, CDKN1A, EGFR
1610.8ERBB2, CDKN1A, EGFR
1710.8EGFR, CDKN1A, TP53
1810.8ERBB2, CDH1, EGFR
19
Hide members
10.8TP53, FGF3, CDKN1A
20
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.8CDKN1A, BIRC7, TP53
21
Hide members
10.7TP53, ERBB2
2210.7ERBB2, EGFR
2310.6EGFR

Compounds for genes affiliated with Transitional Cell Carcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.9TP53, IFI27, FABP5, FABP4, FABP12, EGFR
2paraffin4511.7IFI27, EGFR, CDH1, CDKN1A, KRT13, PTCH1
3retinoid4511.6IFI27, FABP4, FABP12, EGFR, CDH1, CDKN1A
4doxorubicin45 50 1113.6IFI27, EGFR, CDH1, CDKN1A, BIRC7, ERBB2
5cisplatin45 50 60 1114.5IFI27, EGFR, CDH1, CDKN1A, BIRC7, ERBB2
6progesterone45 60 29 11 2415.5IFI27, EGFR, NR2F1, CDH1, CDKN1A, ERBB2
7thymidylate4511.5IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
8oligonucleotide4511.5IFI27, FABP4, MZF1, NR2F1, CDKN1A, FGF3
9troglitazone45 29 60 1114.5IFI27, FABP4, UPK2, CDH1, CDKN1A, KRT13
105fluorouracil4511.5EGFR, CDH1, CDKN1A, BIRC7, ERBB2, TP53
11vegf4511.5IFI27, EGFR, CDH1, CDKN1A, FGF3, ERBB2
12n acetylcysteine4511.5IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
13tamoxifen45 50 29 1114.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
14paclitaxel45 50 1113.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
15ly2940024511.4IFI27, EGFR, CDH1, CDKN1A, ERBB2, TP53
16suberoylanilide hydroxamic acid4511.4EGFR, CDH1, CDKN1A, ERBB2, TP53
17irinotecan45 50 1113.4EGFR, CDH1, CDKN1A, ERBB2, TP53
18gefitinib45 50 1113.4IFI27, EGFR, CDH1, CDKN1A, ERBB2
19geldanamycin45 50 60 1114.4EGFR, CDH1, CDKN1A, ERBB2, TP53
20docetaxel45 50 60 1114.3EGFR, CDH1, CDKN1A, ERBB2, TP53
21mg 13245 6012.3IFI27, EGFR, CDH1, CDKN1A, TP53
22curcumin4511.3EGFR, CDH1, CDKN1A, ERBB2, TP53
23taxane4511.3TP53, ERBB2, CDKN1A, EGFR
24agar4511.3EGFR, CDH1, CDKN1A, FGF3, ERBB2
25indole-3-carbinol4511.3TP53, CDKN1A, CDH1, IFI27
26sulindac45 1112.2IFI27, CDH1, CDKN1A, TP53
27oxaliplatin45 50 1113.2TP53, ERBB2, CDKN1A, EGFR
28vitamin d4511.2ERBB2, KRT13, CDKN1A, CDH1, IFI27
29flavopiridol45 1112.2TP53, ERBB2, CDKN1A, EGFR
30celecoxib45 60 29 50 11 2416.2EGFR, CDH1, CDKN1A, ERBB2
31bortezomib45 1112.2TP53, ERBB2, CDKN1A, EGFR
32rapamycin4511.2IFI27, EGFR, CDH1, CDKN1A, ERBB2
33adpribose4511.2IFI27, EGFR, CDKN1A, TP53
34pki-1664511.2EGFR, CDH1, ERBB2
35hrgbeta14511.2EGFR, CDKN1A, ERBB2
36gemcitabine45 50 1113.2TP53, ERBB2, CDKN1A, EGFR
37resveratrol45 60 11 2414.1IFI27, CDKN1A, ERBB2, TP53
38etoposide45 50 60 1114.1CDH1, BIRC7, ERBB2
39temozolomide45 1112.0EGFR, CDKN1A, TP53
40steroid4511.0ERBB2, FGF3, FABP4, FABP5, IFI27
4117-(allylamino)-17-demethoxygeldanamycin4510.9CDH1, CDKN1A, ERBB2
42p000484510.9CDKN1A, IFI27
43genistein45 29 60 2 11 2415.8IFI27, EGFR, CDH1, CDKN1A, ERBB2
44optimax4510.8CDKN1A, IFI27
45adriamycin4510.8CDKN1A
46estrogen4510.8NR2F1
47erlotinib45 50 1112.8ERBB2, CDH1, EGFR
48Afatinib1110.7EGFR, ERBB2
49depsipeptide4510.7TP53, CDH1
50topotecan45 1111.5TP53, ERBB2, EGFR

GO Terms for genes affiliated with Transitional Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:04801511.0ERBB2, FGF3, CDKN1A, EGFR
2fibroblast growth factor receptor signaling pathwayGO:00854311.0EGFR, CDKN1A, FGF3, ERBB2
3Fc-epsilon receptor signaling pathwayGO:03809511.0ERBB2, FGF3, CDKN1A, EGFR
4epidermal growth factor receptor signaling pathwayGO:00717310.9EGFR, CDKN1A, FGF3, ERBB2
5mitotic cell cycle arrestGO:07185010.7TP53, CDKN1A
6cellular response to lithium ionGO:07128510.7CDH1, FABP4
7epidermis developmentGO:00854410.7FABP5, KRT13, PTCH1
8neurotrophin TRK receptor signaling pathwayGO:04801110.5ERBB2, FGF3, CDKN1A, EGFR

Molecular functions related to Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.7ERBB2, EGFR
2cyclin bindingGO:03033210.7PTCH1, CDKN1A
3protein phosphatase bindingGO:01990310.7ERBB2, CDH1, EGFR
4receptor signaling protein tyrosine kinase activityGO:00471610.4ERBB2, EGFR

Products for genes affiliated with Transitional Cell Carcinoma

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Sources for Transitional Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet