TGA
MCID: TRN044
MIFTS: 36

Transposition of the Great Arteries (TGA) malady

Summaries for Transposition of the Great Arteries

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to ventricular septal defect and double outlet right ventricle. An important gene associated with Transposition of the Great Arteries is MED13L (mediator complex subunit 13-like), and among its related pathways are Signaling by NODAL and HOP Signaling. The compounds candoxatril and celiprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and skin, and related mouse phenotypes are digestive/alimentary and skeleton.

Wikipedia:63 Transposition of the great vessels (TGV) is a group of congenital heart defects involving an abnormal... more...

Aliases & Classifications for Transposition of the Great Arteries

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

transposition of the great arteries 42
transposition of the great arteries, dextro-looped 1 60
dextro-looped transposition of the great arteries 42
dtga 42
tga 42


Related Diseases for Transposition of the Great Arteries

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17GeneCards, 18GeneDecks
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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1ventricular septal defect31.6NKX2-5, GATA4, NPPB
2double outlet right ventricle31.3GDF1, CFC1, HTX2
3hypertension31.3ACE, NPPB
4situs inversus31.2ZIC3, CCDC11, GDF1
5congenital heart defect30.9ACE, NKX2-5, GATA4, NPPB
6heart septal defect30.9NKX2-5, GATA4
7tetralogy of fallot30.8GATA4, NKX2-5, GDF1
8atrioventricular block30.7NPPB, GATA4, NKX2-5
9atrioventricular septal defect30.6NKX2-5, CRELD1, GATA4
10myocardial infarction30.3GATA4, ACE, ANXA5, NPPB
11acute myocardial infarction29.9NPPB, ACE
12congenitally corrected transposition of the great arteries10.8
13dextrocardia10.8
14hypoplastic left heart syndrome10.6
15vascular disease10.6
16transposition of the great arteries, dextro-looped 210.6
17transposition of the great arteries, dextro-looped 110.6
18patent foramen ovale10.5
19wolff-parkinson-white syndrome10.4
20tuberous sclerosis10.4
21cerebritis10.4
22communicating hydrocephalus10.4
23hydrocephalus10.4
24transposition of great arteries, dextro-looped 310.4
25isolated congenitally uncorrected transposition of the great arteries10.4
26congenitally uncorrected transposition of the great arteries with cardiac malformation10.4
27congenitally uncorrected transposition of the great arteries with coarctation10.4
28transient global amnesia10.4
29coronary artery disease10.3
30subclavian steal syndrome10.3
31congenital heart block10.3
32klinefelter's syndrome10.3
33biliary atresia10.3
34renal agenesis10.3
35twin-to-twin transfusion syndrome10.3
36tricuspid valve insufficiency10.3
37tricuspid valve stenosis10.3
38endocardial fibroelastosis10.3
39citrullinemia10.3
40dissecting aortic aneurysm10.3
41scimitar syndrome10.3
42intestinal atresia10.3
43imperforate anus10.3
44glucocorticoid-remediable aldosteronism10.3
45obstructive hydrocephalus10.3
46sick sinus syndrome10.3
47congenital diaphragmatic hernia10.3
48aortic aneurysm10.3
49aortic valve stenosis10.3
50brain disease10.3

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Clinical Features for Transposition of the Great Arteries

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Drugs & Therapeutics for Transposition of the Great Arteries

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Transposition of the Great Arteries

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Anatomical Context for Transposition of the Great Arteries

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32MalaCards
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MalaCards organs/tissues related to Transposition of the Great Arteries:

32
Heart, Lung, Skin

Animal Models for Transposition of the Great Arteries or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Transposition of the Great Arteries:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5ZIC3, GATA4, PITX2, GDF1, IL6, CFC1
2MP:00053908.5CFC1, IL6, GDF1, PITX2, GATA4, ZIC3
3MP:00053708.3ZIC3, GATA4, PITX2, GDF1, IL6, CFC1
4MP:00053888.2ZIC3, GATA4, PITX2, NKX2-5, NKX2-6, GDF1
5MP:00028738.1ZIC3, GATA4, PITX2, NKX2-5, NKX2-6, ANXA5
6MP:00053808.1ZIC3, GATA4, PITX2, MED24, NKX2-5, NKX2-6
7MP:00053697.7NPPB, GATA4, PITX2, MED24, NKX2-5, IL6
8MP:00053977.4ZIC3, GATA4, PITX2, MED24, NKX2-5, GDF1
9MP:00053877.4ZIC3, PITX2, NKX2-5, ANXA5, GDF1, IL6
10MP:00053787.1ZIC3, GATA4, PITX2, MED24, NKX2-5, NKX2-6
11MP:00107687.1MED24, PITX2, GATA4, ZIC3, NKX2-5, NKX2-6
12MP:00053856.8ACE, ZIC3, NPPB, GATA4, PITX2, MED24

Publications for Transposition of the Great Arteries

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Genetic Variations for Transposition of the Great Arteries

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Expression for genes affiliated with Transposition of the Great Arteries

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transposition of the Great Arteries

Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CFC1, GDF1
29.8GATA4, NKX2-5
39.5NKX2-5, PITX2, GATA4
4
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9.4NKX2-5, GATA4, NPPB
59.4NKX2-5, GATA4, NPPB

Compounds for genes affiliated with Transposition of the Great Arteries

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1candoxatril44 1110.9NPPB, ACE
2celiprolol449.9NPPB, ACE
3alacepril449.9NPPB, ACE
4imidapril449.9ACE, NPPB
5trandolapril44 1110.9NPPB, ACE
6bisoprolol44 49 1111.9NPPB, ACE
7fosinopril44 1110.9ACE, NPPB
8moxonidine449.9ACE, NPPB
9enalaprilat449.9NPPB, ACE
10lisinopril44 11 2411.8ACE, NPPB
11metoprolol44 28 49 11 2413.8ACE, NPPB
12ramipril44 1110.7NPPB, ACE
13taurolidine449.7IL6, ANXA5
14atenolol44 28 49 11 2413.6ACE, NPPB
15telmisartan44 28 1111.6ACE, NPPB
16tirofiban44 1110.6NPPB, ANXA5
17valsartan44 59 28 1112.5NPPB, ACE
18perindopril44 49 1111.3ACE, NPPB
19zinc44 249.9ZIC3, NPPB, GATA4, NKX2-5, ACE
20nitric oxide44 11 2410.6NPPB, GATA4, NKX2-5, IL6, ACE

GO Terms for genes affiliated with Transposition of the Great Arteries

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16Gene Ontology
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Biological processes related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:05501410.2NKX2-6, NKX2-5
2pulmonary myocardium developmentGO:00335010.1NKX2-5, PITX2
3positive regulation of cardioblast differentiationGO:05189110.0NKX2-5, GATA4
4endocardial cushion developmentGO:00319710.0GATA4, CRELD1
5atrial septum morphogenesisGO:06041310.0GATA4, NKX2-5
6embryonic heart tube developmentGO:0350509.9NKX2-6, NKX2-5
7determination of left/right symmetryGO:0073689.9ZIC3, PITX2, CFC1
8ventricular cardiac muscle cell developmentGO:0550159.8NKX2-6, NKX2-5, PITX2
9ventricular septum morphogenesisGO:0604129.8NKX2-5, PITX2
10heart loopingGO:0019479.8NKX2-5, GATA4, ZIC3
11pharyngeal system developmentGO:0600379.8NKX2-5, NKX2-6
12regulation of vasodilationGO:0423129.7ACE, NPPB
13embryonic digestive tract morphogenesisGO:0485579.5PITX2, GATA4
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.8ZIC3, GATA4, PITX2, NKX2-5, IL6
15positive regulation of transcription, DNA-dependentGO:0458938.7ZIC3, GATA4, MED24, NKX2-5, IL6

Molecular functions related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:0011049.1NKX2-5, MED13L, MED24
2sequence-specific DNA binding transcription factor activityGO:0037008.9NKX2-6, NKX2-5, PITX2, GATA4, ZIC3

Products for genes affiliated with Transposition of the Great Arteries

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Sources for Transposition of the Great Arteries

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet