TGA
MCID: TRN044
MIFTS: 48

Transposition of the Great Arteries (TGA) malady

Categories: Rare diseases

Aliases & Classifications for Transposition of the Great Arteries

Aliases & Descriptions for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 50 29 29
Transposition of the Great Arteries, Dextro-Looped 1 69
Dextro-Looped Transposition of the Great Arteries 50
Dtga 50
Tga 50

Classifications:



Summaries for Transposition of the Great Arteries

NIH Rare Diseases : 50 transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards based summary : Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to imperforate anus and congenitally corrected transposition of the great arteries. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways/superpathways are Developmental Biology and Mesodermal Commitment Pathway. The drugs Spironolactone and Eplerenone have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are cardiovascular system and cellular

Related Diseases for Transposition of the Great Arteries

Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 imperforate anus 29.6 GATA4 NR2F2 ZFPM2
2 congenitally corrected transposition of the great arteries 12.7
3 transposition of the great arteries, dextro-looped 1 12.6
4 transposition of the great arteries, dextro-looped 2 12.5
5 dextro-looped transposition of the great arteries 12.3
6 congenitally uncorrected transposition of the great arteries with coarctation 12.2
7 isolated congenitally uncorrected transposition of the great arteries 12.2
8 congenitally uncorrected transposition of the great arteries with cardiac malformation 12.2
9 transposition of great arteries, dextro-looped 3 12.1
10 transient global amnesia 11.8
11 conotruncal heart malformations 11.7
12 mental retardation and distinctive facial features with or without cardiac defects 11.0
13 congenital heart defects, multiple types, 4 11.0
14 heterotaxy, visceral, 6, autosomal recessive 11.0
15 heterotaxy, visceral, 1, x-linked 11.0
16 med13l syndrome 11.0
17 ventricular septal defect 10.7
18 left ventricular outflow tract obstruction 10.5
19 dextrocardia 10.4
20 situs inversus 10.4
21 pulmonary hypertension 10.3
22 tricuspid atresia 10.3
23 mevalonic aciduria 10.2 CFC1 GDF1 MED13L
24 aortopulmonary window 10.2
25 tetralogy of fallot 10.2
26 heart disease 10.2
27 aneurysm 10.2
28 right inferior vena cava connecting to left-sided atrium 10.2 CRELD1 GATA4
29 subpulmonary stenosis 10.1
30 cor triatriatum 10.1
31 left superior vena cava persisting to left-sided atrium 10.1 CRELD1 GATA4
32 ascending cholangitis 10.1 GDF1 NKX2-6
33 hirschsprung microcephaly cleft palate 10.1 CFAP53 CFC1 ZIC3
34 right aortic arch 10.1
35 hypoplastic left heart syndrome 10.1
36 atrioventricular block 10.1
37 vulvar apocrine adenocarcinoma 10.0 CRELD1 GATA4 NKX2-6
38 persistent eustachian valve 10.0 CRELD1 GATA4 GATA6
39 criss-cross heart 10.0
40 myocardial infarction 10.0
41 congenital diaphragmatic hernia 10.0
42 brain injury 10.0
43 aortic coarctation 10.0
44 sudden cardiac death 10.0
45 atrioventricular septal defect 10.0
46 patent foramen ovale 10.0
47 congenital diarrhea 7 with exudative enteropathy 10.0 CFC1 GDF1 MED13L NKX2-6 ZIC3
48 jmp syndrome 10.0 CFAP53 CFC1 GDF1 PITX2 ZIC3
49 cerebritis 9.9
50 pulmonary vein stenosis 9.9

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to Transposition of the Great Arteries

Symptoms & Phenotypes for Transposition of the Great Arteries

MGI Mouse Phenotypes related to Transposition of the Great Arteries:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ZFPM2 ZIC3 TBX1 NKX2-5 GATA4 NKX2-6
2 cellular MP:0005384 10.1 TBX1 ZFPM2 ZIC3 MED24 NKX2-5 GATA4
3 embryo MP:0005380 10.02 ZIC3 NKX2-5 GATA4 NKX2-6 GATA6 NR2F2
4 digestive/alimentary MP:0005381 9.91 TBX1 ZIC3 NKX2-5 GATA4 NR2F2 PITX2
5 muscle MP:0005369 9.76 ZFPM2 TBX1 NKX2-5 GATA4 NR2F2 GATA6
6 limbs/digits/tail MP:0005371 9.73 TBX1 ZIC3 ANXA5 GATA4 GATA6 PITX2
7 normal MP:0002873 9.65 ZFPM2 ZIC3 ANXA5 NKX2-5 GATA4 NKX2-6
8 respiratory system MP:0005388 9.28 ZFPM2 ZIC3 NKX2-5 GATA4 NKX2-6 GATA6

Drugs & Therapeutics for Transposition of the Great Arteries

Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Eplerenone Approved Phase 4 107724-20-9 150310 443872
3
Mechlorethamine Approved Phase 4 51-75-2 4033
4 diuretics Phase 4
5 Natriuretic Agents Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Diuretics, Potassium Sparing Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Mineralocorticoid Receptor Antagonists Phase 4
11 Mineralocorticoids Phase 4
12
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
13 Vasodilator Agents Phase 3,Phase 2
14 Phosphodiesterase Inhibitors Phase 3,Phase 2
15 Phosphodiesterase 5 Inhibitors Phase 3
16
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
17 N-monoacetylcystine Phase 2
18 Simendan Phase 2
19 Dextrans Phase 2
20 Pharmaceutical Solutions Phase 2
21 Anti-Arrhythmia Agents Phase 2
22 Plasma Substitutes Phase 2
23 Expectorants Phase 2
24 Anti-Infective Agents Phase 2
25 Anticoagulants Phase 2
26 Protective Agents Phase 2
27 Antidotes Phase 2
28 Respiratory System Agents Phase 2
29 Blood Substitutes Phase 2
30 Antiviral Agents Phase 2
31 Antioxidants Phase 2
32 Epoetin alfa Phase 1, Phase 2 113427-24-0
33 Hematinics Phase 1, Phase 2
34
Dexmedetomidine Approved, Vet_approved Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
35 Adrenergic Agents Phase 1
36 Neurotransmitter Agents Phase 1
37 Analgesics Phase 1
38 Adrenergic Agonists Phase 1
39 Adrenergic alpha-2 Receptor Agonists Phase 1
40 Adrenergic alpha-Agonists Phase 1
41 Analgesics, Non-Narcotic Phase 1
42 Peripheral Nervous System Agents Phase 1
43 Hypnotics and Sedatives Phase 1
44 Central Nervous System Depressants Phase 1
45
Dobutamine Approved 34368-04-2 36811
46 Adrenergic Antagonists
47 Adrenergic beta-Antagonists

Interventional clinical trials:

(show all 38)
id Name Status NCT ID Phase
1 Eplerenone in Systemic Right Ventricle Completed NCT00703352 Phase 4
2 The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease Terminated NCT01971593 Phase 4
3 Comparison of Hematocrit Levels in Infant Heart Surgery Completed NCT00006183 Phase 3
4 Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest Completed NCT00000470 Phase 3
5 COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction Recruiting NCT02744677 Phase 3
6 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function Not yet recruiting NCT03049540 Phase 3
7 Levosimendan Administration in Neonates With Transposition of the Great Arteries Completed NCT01120106 Phase 2
8 N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Completed NCT00374088 Phase 2
9 Hypertonic Saline Dextran in Pediatric Cardiac Surgery Completed NCT00199771 Phase 2
10 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting NCT00513240 Phase 1, Phase 2
11 A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics Recruiting NCT01915277 Phase 1
12 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
13 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
14 Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular Function Completed NCT00313352
15 CT Coronary Angiography After Arterial Switch Operation Completed NCT01153776
16 Physical Training in Transposition of the Great Arteries Completed NCT00837603
17 Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings Completed NCT01430897
18 Myocardial Contrast Echocardiography in Congenital Heart Disease Completed NCT00412685
19 Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic Methods Completed NCT01907971
20 Quality of Life in Young Adults With Congenital Heart Disease Completed NCT02463292
21 Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental Outcome Completed NCT00713635
22 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
23 Genes Causing Ebstein's Anomaly Completed NCT00497705
24 A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect Completed NCT02361008
25 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
26 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Recruiting NCT02415491
27 Genetic Determinants of Congenital Heart Disease Outcomes Recruiting NCT01656941
28 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
29 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Recruiting NCT02184169
30 Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults. Recruiting NCT02542345
31 Assessing Neurodevelopment in Congenital Heart Disease. Recruiting NCT02996630
32 Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility Study Recruiting NCT03022708
33 Surgical Planning for Reconstruction of Complex Heart Defects Recruiting NCT00972608
34 National Congenital Heart Disease Audit Recruiting NCT02303535
35 Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract Reconstruction Active, not recruiting NCT02700100
36 Late Function After Surgery for Transposition of the Great Arteries Enrolling by invitation NCT03078413
37 The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease Not yet recruiting NCT03073122
38 Trial Comparing One-stage With Two-stage Basilic Vein Transposition Terminated NCT01274117

Search NIH Clinical Center for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

Genetic tests related to Transposition of the Great Arteries:

id Genetic test Affiliating Genes
1 Transposition of Great Arteries 29
2 Transposition of the Great Arteries 29

Anatomical Context for Transposition of the Great Arteries

MalaCards organs/tissues related to Transposition of the Great Arteries:

39
Heart, Skin, Lung, Brain, Testes, Liver, Pituitary

Publications for Transposition of the Great Arteries

Articles related to Transposition of the Great Arteries:

(show top 50) (show all 791)
id Title Authors Year
1
The use of contrast echo to detect shunts at atrial level in a Mustard or Senning repair for transposition of the great arteries: you can teach an old dog new tricks. ( 28065912 )
2017
2
Transposition of the Great Arteries in the Developing World: Surgery and Outcomes. ( 28057249 )
2017
3
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries. ( 28064156 )
2017
4
Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum. ( 28077506 )
2017
5
Mid-term Outcomes in Patients with Congenitally Corrected Transposition of the Great Arteries: A Single Center Experience. ( 28088601 )
2017
6
Play the Map: Ablation of a Macro Reentrant Atrial Tachycardia in a Patient After Senning Repair for Transposition of the Great Arteries. ( 28045674 )
2017
7
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation. ( 28057382 )
2017
8
Surgical Treatment of Complete Transposition of the Great Arteries in Newborn. ( 27647199 )
2016
9
Mechanisms and predictors of recurrent tachycardia after catheter ablation for d-transposition of the great arteries after the Mustard or Senning operation. ( 27908766 )
2016
10
Longitudinal strain of systemic right ventricle correlates with exercise capacity in adult with transposition of the great arteries after atrial switch. ( 27179205 )
2016
11
Severe Pulmonary Vascular Obstructive Disease After Neonatal Arterial Switch Operation for Simple Transposition of the Great Arteries. ( 27098605 )
2016
12
Aortic Translocation for Repair of Transposition of the Great Arteries (S,D,L) With Ventricular Septal Defect and Pulmonic Stenosis. ( 26694279 )
2016
13
Processing Speed, Executive Function, and Academic Achievement in Children With Dextro-Transposition of the Great Arteries: Testing a Longitudinal Developmental Cascade Model. ( 27077787 )
2016
14
Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography. ( 27659876 )
2016
15
Understanding the mechanism for branch pulmonary artery stenosis after the arterial switch operation for transposition of the great arteries. ( 27025515 )
2016
16
Mapping and ablation of anteroseptal atrial tachycardia in patients with congenitally corrected transposition of the great arteries: implication of pulmonary sinus cusps. ( 27965318 )
2016
17
Percutaneous tricuspid valve repair using MitraClipAr for the treatment of severe tricuspid valve regurgitation in a patient with congenitally corrected transposition of the great arteries. ( 27412162 )
2016
18
"Single coronary" in transposition of the great arteries: Why are we still talking about it? ( 27131848 )
2016
19
Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries. ( 27547505 )
2016
20
Echocardiography vs magnetic resonance imaging in assessing ventricular function and systemic atrioventricular valve status in adults with congenitally corrected transposition of the great arteries. ( 27542349 )
2016
21
Acute myocardial infarction with isolated congenitally corrected transposition of the great arteries. ( 27034557 )
2016
22
Children and Adolescents Show Altered Visual Working Memory Related Brain Activity More Than One Decade After Arterial Switch Operation for D-Transposition of the Great Arteries. ( 27918206 )
2016
23
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries). ( 27401272 )
2016
24
Isolated congenitally corrected transposition of the great arteries with dextroversion discovered incidentally in a patient with cocaine-induced acute myocardial infarction. ( 27034558 )
2016
25
HeartWare ventricular assist device as a bridge to heart transplantation in a patient with congenitally corrected transposition of the great arteries and dextrocardia. ( 27521176 )
2016
26
Pulmonary Arterial Hypertension and Neonatal Arterial Switch Surgery for Correction of Transposition of the Great Arteries. ( 27156642 )
2016
27
Survival of Three Neonates With Congenital Diaphragmatic Hernia and d-Transposition of the Great Arteries. ( 27154795 )
2016
28
MelodyAr pulmonary valve implantation in two teenage patients with congenitally corrected transposition of the great arteries status after Senning atrial switch operation. ( 27748225 )
2016
29
Assessment of myocardial function using MRI-based feature tracking in adults after atrial repair of transposition of the great arteries: Reference values and clinical utility. ( 27389449 )
2016
30
D-Transposition of the Great Arteries and ductal dependent pulmonary circulation. ( 28041645 )
2016
31
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction. ( 27130951 )
2016
32
When left turns to right: a congenital corrected transposition of the great arteries with an azygos continuation without another major cardiac abnormality. ( 27401820 )
2016
33
In situ reconstruction using the half-ring-shaped aortic wall for transposition of the great arteries. ( 27064080 )
2016
34
Atrial tachyarrhythmias after atrial switch operation for transposition of the great arteries: Treating old surgery with new catheters. ( 27018378 )
2016
35
Multimodality Imaging Guidelines of Patients with Transposition of the Great Arteries: A Report from the American Society of Echocardiography Developed inA Collaboration with the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. ( 27372954 )
2016
36
Prenatal Echocardiographic Assessment of Foramen Ovale Appearance in Fetuses with D-Transposition of the Great Arteries and Impact on Neonatal Outcome. ( 27654925 )
2016
37
Transposition of the Great Arteries and Common Variants. ( 27490620 )
2016
38
Long-Term Follow-Up of the Conal Flap Method for Tricuspid Malinsertion in Transposition of the Great Arteries With Ventricular Septal Defect and Pulmonary Stenosis. ( 27083244 )
2016
39
Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome. ( 27892741 )
2016
40
Pregnancy in women with complete transposition of the great arteries following the atrial switch procedure. A study from three of the largest Adult Congenital Heart Disease centers in Poland. ( 27072884 )
2016
41
Hemodynamic consequences of a restrictive ductus arteriosus and foramen ovale in fetal transposition of the great arteries. ( 27589547 )
2016
42
Re: Late diagnosis of isolated congenitally corrected transposition of the great arteries in a 92-year old woman. ( 26834232 )
2016
43
Internal Cardioverter Defibrillator Indications and Therapies after Atrial Baffle Procedure for d-Transposition of the Great Arteries: A Multicenter Analysis. ( 27503213 )
2016
44
Transposition of the great arteries: Rationale for tailored preoperative management. ( 28024917 )
2016
45
Double Switch Procedure and Surgical Alternatives for the Treatment of Congenitally Corrected Transposition of the Great Arteries. ( 26956686 )
2016
46
Current mid-term outcome with an integrated surgical strategy for correction of d-transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction. ( 27009103 )
2016
47
Reoperations and catheter interventions in patients with transposition of the great arteries after the arterial switch operation. ( 27615267 )
2016
48
Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation. ( 27847084 )
2016
49
Long-Term Follow-Up of the Half-Turned Truncal Switch Operation for Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis. ( 27064891 )
2016
50
Successful thrombolytic therapy in a patient with congenital corrected transposition of the great arteries. ( 28000492 )
2016

Variations for Transposition of the Great Arteries

ClinVar genetic disease variations for Transposition of the Great Arteries:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MED13L NM_015335.4(MED13L): c.752A> G (p.Glu251Gly) single nucleotide variant Pathogenic rs28940309 GRCh37 Chromosome 12, 116457651: 116457651
2 MED13L NM_015335.4(MED13L): c.5615G> A (p.Arg1872His) single nucleotide variant Pathogenic rs28940310 GRCh37 Chromosome 12, 116413092: 116413092
3 MED13L NM_015335.4(MED13L): c.6068A> G (p.Asp2023Gly) single nucleotide variant Pathogenic rs121918333 GRCh37 Chromosome 12, 116406902: 116406902
4 MED13L NM_015335.4(MED13L): c.5285delT (p.Leu1762Argfs) deletion Pathogenic rs886043314 GRCh37 Chromosome 12, 116418634: 116418634

Expression for Transposition of the Great Arteries

Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for Transposition of the Great Arteries

Pathways related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 CFC1 GDF1 MED13L MED24 MIR1469 NR2F2
2
Show member pathways
11.84 GATA4 GATA6 PITX2 TBX1 ZIC3
3 11.77 GATA6 MIR1469 NR2F2
4 11.5 GATA4 MED13L MED24
5 11.17 GATA4 GATA6 ZIC3
6 10.68 GATA4 GATA6 NKX2-5 PITX2 TBX1
7 10.66 GATA4 NKX2-5
8 9.93 GATA4 NKX2-5

GO Terms for Transposition of the Great Arteries

Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.91 GATA6 NR2F2 PITX2 ZFPM2
2 blood coagulation GO:0007596 9.91 ANXA5 GATA4 GATA6 ZFPM2
3 heart development GO:0007507 9.89 NKX2-5 NKX2-6 PITX2 TBX1 ZFPM2
4 male gonad development GO:0008584 9.83 GATA4 GATA6 PITX2
5 lung development GO:0030324 9.82 PITX2 ZFPM2 ZIC3
6 anterior/posterior pattern specification GO:0009952 9.82 NR2F2 TBX1 ZIC3
7 vasculogenesis GO:0001570 9.77 NKX2-5 PITX2 ZFPM2
8 heart looping GO:0001947 9.76 GATA4 NKX2-5 ZIC3
9 ventricular septum morphogenesis GO:0060412 9.71 NKX2-5 PITX2 ZFPM2
10 thyroid gland development GO:0030878 9.67 NKX2-5 TBX1
11 positive regulation of cardiac muscle cell proliferation GO:0060045 9.66 GATA6 ZFPM2
12 response to vitamin A GO:0033189 9.66 GATA4 PITX2
13 embryonic heart tube development GO:0035050 9.65 NKX2-5 NKX2-6
14 pharyngeal system development GO:0060037 9.65 NKX2-5 NKX2-6 TBX1
15 atrial septum morphogenesis GO:0060413 9.64 GATA4 NKX2-5
16 lymph vessel development GO:0001945 9.63 NR2F2 TBX1
17 endocardial cushion development GO:0003197 9.62 CRELD1 GATA4
18 cardiac ventricle morphogenesis GO:0003208 9.62 GATA4 NKX2-5
19 cardiac muscle cell differentiation GO:0055007 9.62 GATA4 GATA6 NKX2-5 PITX2
20 ventricular cardiac muscle cell development GO:0055015 9.61 NKX2-5 NKX2-6 PITX2
21 intestinal epithelial cell differentiation GO:0060575 9.6 GATA4 GATA6
22 atrial cardiac muscle cell development GO:0055014 9.56 NKX2-5 NKX2-6
23 outflow tract septum morphogenesis GO:0003148 9.56 GATA6 NKX2-5 TBX1 ZFPM2
24 pulmonary myocardium development GO:0003350 9.55 NKX2-5 PITX2
25 positive regulation of cardioblast differentiation GO:0051891 9.54 GATA4 GATA6 NKX2-5
26 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.51 NKX2-5 ZFPM2
27 cardiac muscle tissue development GO:0048738 9.46 GATA6 NKX2-5 PITX2 ZFPM2
28 determination of left/right symmetry GO:0007368 9.35 CFAP53 CFC1 PITX2 TBX1 ZIC3
29 positive regulation of transcription, DNA-templated GO:0045893 9.28 GATA4 GATA6 MED24 NKX2-5 NR2F2 PITX2
30 transcription, DNA-templated GO:0006351 10.29 GATA4 GATA6 MED13L MED24 NKX2-6 NR2F2
31 regulation of transcription, DNA-templated GO:0006355 10.18 GATA4 GATA6 MED13L MED24 NKX1-2 NKX2-5
32 multicellular organism development GO:0007275 10.13 CFAP53 CFC1 NKX1-2 NKX2-5 NKX2-6 PITX2
33 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.12 GATA4 GATA6 NKX2-5 PITX2 TBX1 ZFPM2
34 regulation of transcription from RNA polymerase II promoter GO:0006357 10.04 MED13L MED24 NKX2-5 NR2F2 PITX2 TBX1
35 transcription from RNA polymerase II promoter GO:0006366 10 GATA4 GATA6 MED24 NKX2-5 PITX2 ZFPM2

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.65 GATA4 GATA6 NKX2-5 PITX2 ZFPM2
2 transcription factor activity, sequence-specific DNA binding GO:0003700 9.56 GATA4 GATA6 NKX2-5 NKX2-6 NR2F2 PITX2
3 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 9.54 GATA4 GATA6 NKX2-5
4 RNA polymerase II transcription factor binding GO:0001085 9.5 GATA4 GATA6 ZFPM2
5 RNA polymerase II transcription cofactor activity GO:0001104 9.33 MED13L MED24 NKX2-5
6 sequence-specific DNA binding GO:0043565 9.28 GATA4 GATA6 NKX1-2 NKX2-5 NKX2-6 NR2F2
7 DNA binding GO:0003677 10.01 GATA4 GATA6 NKX2-5 NR2F2 PITX2 TBX1

Sources for Transposition of the Great Arteries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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