MCID: TRN044
MIFTS: 48

Transposition of the Great Arteries malady

Category: Rare diseases

Aliases & Classifications for Transposition of the Great Arteries

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Aliases & Descriptions for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 46 25
Transposition of the Great Arteries, Dextro-Looped 1 66
Dextro-Looped Transposition of the Great Arteries 46
 
Dtga 46
Tga 46

Classifications:



Summaries for Transposition of the Great Arteries

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NIH Rare Diseases:46 Transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards based summary: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to azygos continuation of the inferior vena cava and intestinal atresia. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Related Diseases for Transposition of the Great Arteries

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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1azygos continuation of the inferior vena cava30.0CRELD1, GATA4
2intestinal atresia29.8GATA4, NR2F2, ZFPM2
3congenitally corrected transposition of the great arteries12.7
4transposition of the great arteries, dextro-looped 112.6
5transposition of the great arteries, dextro-looped 212.5
6congenitally uncorrected transposition of the great arteries12.3
7isolated congenitally uncorrected transposition of the great arteries12.3
8congenitally uncorrected transposition of the great arteries with cardiac malformation12.3
9congenitally uncorrected transposition of the great arteries with coarctation12.3
10transposition of great arteries, dextro-looped 311.9
11conotruncal heart malformations11.6
12transient global amnesia11.5
13ventricular septal defect10.8
14left ventricular outflow tract obstruction10.6
15dextrocardia10.5
16situs inversus10.5
17pulmonary hypertension10.4
18suppurative cholangitis10.4GDF1, NKX2-6
19undifferentiated carcinoma of the corpus uteri10.4CFC1, GDF1, MED13L
20tricuspid atresia10.4
21otosclerosis 110.4MIR1469, NR2F2
22esophageal atresia10.3NKX2-6, ZFPM2
23aortopulmonary window10.3
24tetralogy of fallot10.3
25heart disease10.3
26congenital heart disease10.3
27aneurysm10.3
28radioulnar synostosis10.2MIR1469, NR2F2, ZIC3
29uniparental disomy of chromosome 1110.2GATA6, NR2F2, ZIC3
30cor triatriatum10.2
31subpulmonary stenosis10.2
32drug-induced vasculitis10.2GATA4, ZFPM2
33hypoplastic left heart syndrome10.2
34atrioventricular block10.2
35right aortic arch10.2
36hhv-6 encephalitis10.2CFAP53, CFC1, ZIC3
37univentricular heart with single atrio-ventricular valve10.1CRELD1, GATA4
38congenital heart defects, multiple types, 410.1
39heterotaxy, visceral, 6, autosomal recessive10.1
40heterotaxy, visceral, 1, x-linked10.1
41med13l syndrome10.1
426-phosphogluconate dehydrogenase deficiency10.1GATA4, NKX2-5, NKX2-6
43myocardial infarction10.1
44brain injury10.1
45atrioventricular septal defect10.1
46patent foramen ovale10.1
47congenital diaphragmatic hernia10.1
48aortic coarctation10.1
49sudden cardiac death10.1
50criss-cross heart10.1

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Symptoms for Transposition of the Great Arteries

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Drugs & Therapeutics for Transposition of the Great Arteries

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Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1diureticsPhase 41338
2
MechlorethaminePhase 436351-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
 
KBioGR_001448
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
3
SpironolactonePhase 42171952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
4
EplerenonePhase 492107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
5
AcetylcysteinePhase 2304616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
6Epoetin alfaPhase 1, Phase 2638113427-24-0
7
DexmedetomidinePhase 151576631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
8
Dobutamine11134368-04-236811
Synonyms:
(+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
(+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
34368-04-2
34368-04-2 (Parent)
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
52663-81-7 (hydrochloride)
74753-15-4
74753-15-4 (hydrobromide)
AC1L1WFF
AC1Q7AD1
BPBio1_000489
BRD-A78322124-003-03-3
BSPBio_000443
C06967
CHEBI:4670
CHEMBL926
CID36811
D03879
DB00841
DL-Dobutamine
DL-dobutamine
Dobutamin
Dobutamina
Dobutamina [INN-Spanish]
Dobutamine
Dobutamine (USP/INN)
Dobutamine Hcl
Dobutamine Hcl in Dextrose 5%
 
Dobutamine Hydrochloride
Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer
Dobutamine [USAN:BAN:INN]
Dobutamine [USAN]
Dobutamine [Usan:Ban:Inn]
Dobutamine [Usan]
Dobutamine hydrobromide
Dobutaminum
Dobutaminum [INN-Latin]
Dobutrex
EINECS 277-982-4
HMS2089K05
Inotrex
L001157
LS-174467
LY 81929
Lilly 81929
Lopac0_000365
NCGC00015321-05
NCGC00024629-02
NCGC00024629-03
Prestwick0_000352
Prestwick1_000352
Prestwick2_000352
Prestwick3_000352
Racemic-Dobutamine
Racemic-dobutamine
SPBio_002364
UNII-0WR771DJXV
UNII-3S12J47372
dobutamine
dobutamine(usp)
rac-Dobutamine
rac-dobutamine
racemic-Dobutamine

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1Eplerenone in Systemic Right VentricleCompletedNCT00703352Phase 4
2The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseTerminatedNCT01971593Phase 4
3Comparison of Hematocrit Levels in Infant Heart SurgeryCompletedNCT00006183Phase 3
4Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
5Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve DysfunctionRecruitingNCT02744677Phase 3
6Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 2
7N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)CompletedNCT00374088Phase 2
8Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
9Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
10A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
11MRI Study After Arterial Switch Operation in Patients With Transposition of the Great ArteriesCompletedNCT01916499
12Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular FunctionCompletedNCT00313352
13CT Coronary Angiography After Arterial Switch OperationCompletedNCT01153776
14Physical Training in Transposition of the Great ArteriesCompletedNCT00837603
15Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) FindingsCompletedNCT01430897
16Myocardial Contrast Echocardiography in Congenital Heart DiseaseCompletedNCT00412685
17Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
18Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic MethodsCompletedNCT01907971
19Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental OutcomeCompletedNCT00713635
20Quality of Life in Young Adults With Congenital Heart DiseaseCompletedNCT02463292
21A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
22Genes Causing Ebstein's AnomalyCompletedNCT00497705
23Fibrosis, Valvular and Ventricular Function in Patients With TGARecruitingNCT02588989
24Genetic Determinants of Congenital Heart Disease OutcomesRecruitingNCT01656941
25Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young AdultsRecruitingNCT02415491
26Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic ResonanceRecruitingNCT02161471
27Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)RecruitingNCT02184169
28T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart DiseaseRecruitingNCT02350829
29Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults.RecruitingNCT02542345
30Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract ReconstructionRecruitingNCT02700100
31Surgical Planning for Reconstruction of Complex Heart DefectsRecruitingNCT00972608
32National Congenital Heart Disease AuditRecruitingNCT02303535
33Trial Comparing One-stage With Two-stage Basilic Vein TranspositionTerminatedNCT01274117

Search NIH Clinical Center for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

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Genetic tests related to Transposition of the Great Arteries:

id Genetic test Affiliating Genes
1 Transposition of Great Arteries25
2 Transposition of the Great Arteries25

Anatomical Context for Transposition of the Great Arteries

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MalaCards organs/tissues related to Transposition of the Great Arteries:

34
Heart, Skin, Lung, Brain, Testes, Liver, Pituitary

Animal Models for Transposition of the Great Arteries or affiliated genes

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MGI Mouse Phenotypes related to Transposition of the Great Arteries:

39 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9GATA4, GATA6, GDF1, PITX2, ZFPM2, ZIC3
2MP:00053718.2ANXA5, GATA4, GATA6, PITX2, TBX1, ZIC3
3MP:00053888.0GATA4, GATA6, GDF1, NKX2-5, NKX2-6, PITX2
4MP:00053697.9GATA4, GATA6, MED24, NKX2-5, NR2F2, PITX2
5MP:00053847.5GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
6MP:00053977.5ANXA5, GATA4, GATA6, GDF1, MED24, NKX2-5
7MP:00053807.4GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
8MP:00028737.3ANXA5, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
9MP:00107687.0GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
10MP:00053786.9GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
11MP:00053856.8GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6

Publications for Transposition of the Great Arteries

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Articles related to Transposition of the Great Arteries:

(show top 50)    (show all 766)
idTitleAuthorsYear
1
Juxtaposed right atrial appendage in complex Transposition of the Great Arteries. (25583626)
2015
2
Editorial comment: the use of veno-venous extracorporeal membrane oxygenation for perinatal support of an infant with d-transposition of the great arteries, intact atrial and ventricular septa, and flow-restricted ductus arteriosus. (25611995)
2014
3
Congenitally corrected transposition of the great arteries: situs solitus or inversus. (25227238)
2014
4
Transvenous cardiac resynchronization therapy in congenitally corrected transposition of the great arteries and progressive heart failure. (24507741)
2014
5
Earlier Arterial Switch Operation Improves Outcomes and Reduces Costs for Neonates with Transposition of the Great Arteries. (24184243)
2013
6
The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle. (23427188)
2013
7
Remote Monitoring Leads to Early Recognition and Treatment of Critical Arrhythmias in Adults After Atrial Switch Operation for Transposition of the Great Arteries. (24317113)
2013
8
Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. (23331588)
2012
9
Autonomic nervous system function in infants with transposition of the great arteries. (21613339)
2012
10
Complete atrioventricular block in an adult with congenitally corrected transposition of the great arteries with interrupted inferior vena cava. (23798952)
2012
11
Long-term prognosis of double-switch operation for congenitally corrected transposition of the great arteries. (22551964)
2012
12
Perioperative care of a child with transposition of the great arteries. (21706195)
2011
13
The modified Senning procedure as an integral part of an anatomical correction of congenitally corrected transposition of the great arteries. (24414198)
2011
14
Editorial comment Corrected transposition of the great arteries: is 'anatomic' repair the optimal option? (21515064)
2011
15
Catheter Ablation of Hemodynamically Unstable Ventricular Tachycardia in a Patient with Dextro - Transposition of the Great Arteries and Mustard's Repair. (21760683)
2011
16
Late arrhythmias after surgery for transposition of the great arteries. (23804930)
2011
17
Detection of a coronary artery anomaly after a sudden cardiac arrest in a 17 Year-old with D-transposition of the great arteries status post arterial switch operation: a case report. (21453426)
2011
18
The Senning procedure as part of the double-switch operations for congenitally corrected transposition of the great arteries. (21444057)
2011
19
Long-term outcomes after an arterial switch operation for simple complete transposition of the great arteries. (20111649)
2010
20
Do predictors exist for a successful withdrawal of preoperative prostaglandin E(1) from neonates with d-transposition of the great arteries and intact ventricular septum? (20886209)
2010
21
Long-term coronary artery outcome after arterial switch operation for transposition of the great arteries. (20452235)
2010
22
Congenitally corrected transposition of the great arteries: a unique case from Iraq. (19787386)
2010
23
A reminder from the past: a 49-year-old patient with transposition of the great arteries palliated with Dr. Thomas Baffes' and Dr. William Mustard's original operations. (19647403)
2009
24
Enlarged bronchial collateral artery complicating recovery after arterial switch for simple transposition of the great arteries. (18757452)
2008
25
Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation. (18760127)
2008
26
Cardiac defibrillation therapy for at risk patients with systemic right ventricular dysfunction secondary to atrial redirection surgery for dextro-transposition of the great arteries. (17383987)
2007
27
Metabolic alterations and neurodevelopmental outcome of infants with transposition of the great arteries. (16897317)
2006
28
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006
29
Primary surgical correction of transposition of the great arteries and atrioventricular septal defect associated with left isomerism. (16391973)
2006
30
Ablation of atrioventricular conduction in corrected transposition of the great arteries. (16648068)
2006
31
Successful repair of transposition of the great arteries with right aortic arch and coarctation of the aorta. (16482932)
2006
32
Relation between right ventricular structural alterations and markers of adverse clinical outcome in adults with systemic right ventricle and either congenital complete (after Senning operation) or congenitally corrected transposition of the great arteries. (17056346)
2006
33
Arterial switch operation for transposition of the great arteries combined with closure of paramembranous ventricular septal defect using the Amplatzer membranous ventricular septal occluder. (16098318)
2005
34
Prenatal diagnosis of congenitally corrected transposition of the great arteries. A case report. (15608453)
2005
35
Sub-pulmonary ventricular failure resulting from pulmonary hypertension in transposition of the great arteries palliated by atrial switch. (16243120)
2005
36
Arterial switch operation for transposition of the great arteries with coronary arteries from a single aortic sinus. (16039219)
2005
37
Congenitally corrected transposition of the great arteries. (16049650)
2005
38
Assessment of systemic right ventricular function in patients with transposition of the great arteries using the myocardial performance index: comparison with cardiac magnetic resonance imaging. (15533860)
2004
39
Combined arterial switch and Senning operation for congenitally corrected transposition of the great arteries: patient selection and intermediate results. (12658191)
2003
40
Apico-pulmonary artery conduit repair of congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary outflow tract obstruction: a 10-year follow-up. (14602256)
2003
41
Outcome of 121 patients with congenitally corrected transposition of the great arteries. (11889523)
2002
42
Congenitally corrected transposition of the great arteries in a 65-year-old woman. (11804307)
2001
43
Transposition of the great arteries, pulmonary atresia, and multiple ventricular septal defects associated with multiple cardiac rhabdomyomas in a case of tuberous sclerosis. (10754091)
2000
44
Radiofrequency ablation of a posteroseptal atrioventricular accessory pathway in a left-sided tricuspid ring with Ebsteinlike anomaly in a patient with congenitally corrected transposition of the great arteries. (10666764)
2000
45
Systemic ventricular inflow obstruction in congenitally corrected transposition of the great arteries. (9130433)
1997
46
Echocardiography of the right ventricle-to-pulmonary artery homograft conduit of patients with transposition of the great arteries or double outlet right ventricle undergoing the Rastelli procedure. (9294916)
1997
47
Congenitally corrected transposition of the great arteries and exercise-induced ventricular tachycardia. (8640601)
1996
48
Tricuspid atresia with transposition of the great arteries in adolescents and adults: current state and late complications. (3342144)
1988
49
The Mustard procedure in transposition of the great arteries associated with juxtaposition of the atrial appendages with and without dextrocardia. (6827853)
1983
50
Surgical repair of congenitally corrected transposition of the great arteries: results and follow-up. (7124635)
1982

Variations for Transposition of the Great Arteries

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Expression for genes affiliated with Transposition of the Great Arteries

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Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

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Pathways related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6GATA4, NKX2-5
29.6GATA4, NKX2-5
39.1GATA4, MED13L, MED24
48.7GATA4, GATA6, NKX2-5, PITX2, TBX1

GO Terms for genes affiliated with Transposition of the Great Arteries

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Cellular components related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056345.3ANXA5, GATA4, GATA6, MED24, MIR1469, MIR423

Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:005501410.7NKX2-5, NKX2-6
2right ventricular cardiac muscle tissue morphogenesisGO:000322110.7NKX2-5, ZFPM2
3pulmonary myocardium developmentGO:000335010.6NKX2-5, PITX2
4thyroid gland developmentGO:003087810.6NKX2-5, TBX1
5positive regulation of cardiac muscle cell proliferationGO:006004510.5GATA6, ZFPM2
6embryonic heart tube developmentGO:003505010.5NKX2-5, NKX2-6
7pharyngeal system developmentGO:006003710.4NKX2-5, NKX2-6, TBX1
8ventricular septum morphogenesisGO:006041210.2NKX2-5, PITX2, ZFPM2
9ventricular cardiac muscle cell developmentGO:005501510.2NKX2-5, NKX2-6, PITX2
10atrial septum morphogenesisGO:006041310.2GATA4, NKX2-5
11vasculogenesisGO:000157010.2NKX2-5, PITX2, ZFPM2
12intestinal epithelial cell differentiationGO:006057510.2GATA4, GATA6
13regulation of transcription involved in lymphatic endothelial cell fate commitmentGO:006084910.1MIR1469, NR2F2
14radial pattern formationGO:000995610.1MIR1469, NR2F2
15trophoblast giant cell differentiationGO:006070710.1MIR1469, NR2F2
16outflow tract septum morphogenesisGO:000314810.1GATA6, NKX2-5, TBX1, ZFPM2
17lung developmentGO:003032410.1PITX2, ZFPM2, ZIC3
18cardiac ventricle morphogenesisGO:000320810.1GATA4, NKX2-5
19placenta blood vessel developmentGO:006067410.1MIR1469, NR2F2
20positive regulation of systemic arterial blood pressureGO:000308410.1MIR1469, NR2F2
21endocardial cushion developmentGO:000319710.0CRELD1, GATA4
22positive regulation of cardioblast differentiationGO:005189110.0GATA4, GATA6, NKX2-5
23negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.0MIR1469, NR2F2
24maternal placenta developmentGO:00018939.9MIR1469, NR2F2
25cardiac muscle tissue developmentGO:00487389.9GATA6, NKX2-5, PITX2, ZFPM2
26lymph vessel developmentGO:00019459.8MIR1469, NR2F2, TBX1
27cell developmentGO:00484689.8GATA4, GATA6, GDF1
28heart loopingGO:00019479.8GATA4, NKX2-5, ZIC3
29negative regulation of endothelial cell migrationGO:00105969.8MIR1469, NR2F2
30response to vitamin AGO:00331899.7GATA4, PITX2
31blood vessel morphogenesisGO:00485149.6MIR1469, NR2F2, TBX1
32cardiac muscle cell differentiationGO:00550079.6GATA4, GATA6, NKX2-5, PITX2
33male gonad developmentGO:00085849.4GATA4, GATA6, PITX2
34skeletal muscle tissue developmentGO:00075199.4MIR1469, NR2F2, PITX2
35anterior/posterior pattern specificationGO:00099529.4MIR1469, NR2F2, TBX1, ZIC3
36determination of left/right symmetryGO:00073689.3CFC1, PITX2, TBX1, ZIC3
37heart developmentGO:00075079.2NKX2-5, NKX2-6, PITX2, TBX1, ZFPM2
38neuron migrationGO:00017649.0MIR1469, NR2F2, PITX2
39in utero embryonic developmentGO:00017019.0GATA6, MIR1469, NR2F2, PITX2, ZFPM2
40blood coagulationGO:00075968.8ANXA5, GATA4, GATA6, ZFPM2
41negative regulation of transcription, DNA-templatedGO:00458928.8GATA6, MIR1469, NKX2-5, NR2F2, ZFPM2
42transcription from RNA polymerase II promoterGO:00063668.5GATA4, GATA6, MED24, NKX2-5, PITX2, ZIC3
43regulation of transcription from RNA polymerase II promoterGO:00063578.2MED13L, MED24, MIR1469, NKX2-5, NR2F2, PITX2
44positive regulation of transcription from RNA polymerase II promoterGO:00459447.9GATA4, GATA6, NKX2-5, PITX2, TBX1, ZFPM2
45positive regulation of transcription, DNA-templatedGO:00458936.9GATA4, GATA6, MED24, MIR1469, NKX2-5, NR2F2

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:000110410.1MED13L, MED24, NKX2-5
2retinoic acid bindingGO:00019729.9MIR1469, NR2F2
3RNA polymerase II transcription factor bindingGO:00010859.8GATA4, GATA6, ZFPM2
4transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.6GATA4, GATA6, NKX2-5
5chromatin bindingGO:00036829.0GATA4, GATA6, NKX2-5, PITX2
6transcription factor bindingGO:00081348.6GATA4, GATA6, NKX2-5, PITX2, ZFPM2
7transcription factor activity, sequence-specific DNA bindingGO:00037007.4GATA4, GATA6, MIR1469, NKX2-5, NKX2-6, NR2F2
8DNA bindingGO:00036777.3GATA4, GATA6, MIR1469, NKX2-5, NR2F2, PITX2
9sequence-specific DNA bindingGO:00435657.1GATA4, GATA6, MIR1469, NKX2-5, NKX2-6, NR2F2

Sources for Transposition of the Great Arteries

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet