MCID: TRN044
MIFTS: 39

Transposition of the Great Arteries malady

Rare diseases category

Aliases & Classifications for Transposition of the Great Arteries

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Aliases & Descriptions for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 45
Transposition of the Great Arteries, Dextro-Looped 1 65
Dextro-Looped Transposition of the Great Arteries 45
 
Dtga 45
Tga 45


Classifications:



Summaries for Transposition of the Great Arteries

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NIH Rare Diseases:45 Transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards based summary: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to atrioventricular block and biliary atresia. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13-Like), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Transposition of the Great Arteries

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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block30.5CRELD1, GATA4, GATA6, NKX2-5, NKX2-6
2biliary atresia30.4GATA4, GATA6, NKX2-5
3tetralogy of fallot30.1CRELD1, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
4conotruncal heart malformations29.5CFC1, CRELD1, GATA4, GATA6, GDF1, NKX2-5
5congenitally corrected transposition of the great arteries11.5
6ventricular septal defect11.2
7left ventricular outflow tract obstruction11.1
8situs inversus10.9
9dextrocardia10.9
10pulmonary hypertension10.9
11transposition of the great arteries, dextro-looped 210.8
12transposition of the great arteries, dextro-looped 110.8
13tricuspid atresia10.8
14congenital heart disease10.8
15aortopulmonary window10.7
16transposition of great arteries, dextro-looped 310.7
17cor triatriatum10.7
18subpulmonary stenosis10.7
19aneurysm10.7
20hypoplastic left heart syndrome10.6
21right aortic arch10.6
22brain injury10.5
23atrioventricular septal defect10.5
24patent foramen ovale10.5
25coronary arteries congenital malformation10.5
26vascular malformation10.5
27congenitally uncorrected transposition of the great arteries10.5
28isolated congenitally uncorrected transposition of the great arteries10.5
29congenitally uncorrected transposition of the great arteries with cardiac malformation10.5
30criss-cross heart10.5
31congenitally uncorrected transposition of the great arteries with coarctation10.5
32wolff-parkinson-white syndrome10.5
33heterotaxy, visceral, 6, autosomal recessive10.5
34chime syndrome10.5
35hydrocephalus10.5
36single ventricular heart10.5
37tuberous sclerosis10.5
38cerebritis10.5
39cardiac arrest10.5
40communicating hydrocephalus10.5
41aortic coarctation10.5
42complete atrioventricular canal10.5
43pulmonary vein stenosis10.5
44sudden cardiac death10.5
45truncus arteriosus10.5
46aortic valve atresia10.5
47accessory mitral valve tissue10.5
48transient global amnesia10.4
49myocardial infarction10.3
50caudal regression syndrome10.3

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Symptoms for Transposition of the Great Arteries

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Drugs & Therapeutics for Transposition of the Great Arteries

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Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EplerenoneapprovedPhase 487107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
2
MechlorethamineapprovedPhase 441051-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
KBioGR_001448
 
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethamine hydrochloride
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
Valchlor
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
3MineralocorticoidsPhase 4294
4
AcetylcysteineapprovedPhase 2280616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
 
Flumucetin
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Mercapturic acid
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
Sodium 2-acetamido-3-mercaptopropionate
5
Epoetin alfaapprovedPhase 1, Phase 2612113427-24-0
Synonyms:
Epogen
 
Erythropoietin precursor
Procrit
6DextransPhase 269
7Plasma SubstitutesPhase 2125
8Blood SubstitutesPhase 2138
9N-monoacetylcystinePhase 2280
10SimendanPhase 250
11ExpectorantsPhase 2320
12
DexmedetomidineapprovedPhase 1420113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
Dexdor (T)
 
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidine Hydrochloride
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex
Precedex (TN)
Tocris-2023
ZINC04632106
13Adrenergic alpha-2 Receptor AgonistsPhase 1732
14
Dobutamineapproved9934368-04-236811
Synonyms:
(+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
(+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
34368-04-2
34368-04-2 (Parent)
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
52663-81-7 (hydrochloride)
74753-15-4
74753-15-4 (hydrobromide)
AC1L1WFF
AC1Q7AD1
BPBio1_000489
BRD-A78322124-003-03-3
BSPBio_000443
C06967
CHEBI:4670
CHEMBL926
CID36811
D03879
DB00841
DL-Dobutamine
DL-dobutamine
Dobutamin
Dobutamina
Dobutamina [INN-Spanish]
Dobutamine
Dobutamine (USP/INN)
Dobutamine Hcl
Dobutamine Hcl in Dextrose 5%
Dobutamine Hydrochloride
 
Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer
Dobutamine [USAN:BAN:INN]
Dobutamine [USAN]
Dobutamine [Usan:Ban:Inn]
Dobutamine [Usan]
Dobutamine hydrobromide
Dobutamine hydrochloride
Dobutaminum
Dobutaminum [INN-Latin]
Dobutrex
EINECS 277-982-4
HMS2089K05
Inotrex
L001157
LS-174467
LY 81929
Lilly 81929
Lopac0_000365
NCGC00015321-05
NCGC00024629-02
NCGC00024629-03
Prestwick0_000352
Prestwick1_000352
Prestwick2_000352
Prestwick3_000352
Racemic-Dobutamine
Racemic-dobutamine
SPBio_002364
UNII-0WR771DJXV
UNII-3S12J47372
dobutamine
dobutamine(usp)
rac-Dobutamine
rac-dobutamine
racemic-Dobutamine
15Gadolinium DTPA82
16Gadobenic acid82

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Eplerenone in Systemic Right VentricleCompletedNCT00703352Phase 4
2The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseTerminatedNCT01971593Phase 4
3Comparison of Hematocrit Levels in Infant Heart SurgeryCompletedNCT00006183Phase 3
4Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
5Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 2
6N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)CompletedNCT00374088Phase 2
7Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
8Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
9A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
10MRI Study After Arterial Switch Operation in Patients With Transposition of the Great ArteriesCompletedNCT01916499
11Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular FunctionCompletedNCT00313352
12CT Coronary Angiography After Arterial Switch OperationCompletedNCT01153776
13Physical Training in Transposition of the Great ArteriesCompletedNCT00837603
14Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) FindingsCompletedNCT01430897
15Myocardial Contrast Echocardiography in Congenital Heart DiseaseCompletedNCT00412685
16Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
17Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic MethodsCompletedNCT01907971
18A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
19Genes Causing Ebstein's AnomalyCompletedNCT00497705
20Fibrosis, Valvular and Ventricular Function in Patients With TGARecruitingNCT02588989
21Genetic Determinants of Congenital Heart Disease OutcomesRecruitingNCT01656941
22Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young AdultsRecruitingNCT02415491
23Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic ResonanceRecruitingNCT02161471
24Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)RecruitingNCT02184169
25T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart DiseaseRecruitingNCT02350829
26Quality of Life in Young Adults With Congenital Heart DiseaseRecruitingNCT02463292
27Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults.RecruitingNCT02542345
28Surgical Planning for Reconstruction of Complex Heart DefectsRecruitingNCT00972608
29National Congenital Heart Disease AuditRecruitingNCT02303535
30Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental OutcomeActive, not recruitingNCT00713635
31Trial Comparing One-stage With Two-stage Basilic Vein TranspositionTerminatedNCT01274117

Search NIH Clinical Center for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

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Anatomical Context for Transposition of the Great Arteries

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MalaCards organs/tissues related to Transposition of the Great Arteries:

33
Heart, Skin, Lung, Brain, Liver, Pituitary, Testes

Animal Models for Transposition of the Great Arteries or affiliated genes

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MGI Mouse Phenotypes related to Transposition of the Great Arteries:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7CFC1, GATA4, GDF1, NR2F2, PITX2, TBX1
2MP:00053708.7CFC1, GATA4, GATA6, GDF1, PITX2, ZFPM2
3MP:00053697.9GATA4, GATA6, MED24, NKX2-5, NR2F2, PITX2
4MP:00053847.8GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
5MP:00053887.6CFC1, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
6MP:00028737.5ANXA5, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
7MP:00053977.3CFC1, GATA4, GATA6, GDF1, MED24, NKX2-5
8MP:00053807.2CFC1, GATA4, GATA6, GDF1, MED24, NKX2-5
9MP:00053787.1CFC1, GATA4, GATA6, GDF1, MED24, NKX2-5
10MP:00053856.9CFC1, GATA4, GATA6, GDF1, MED24, NKX2-5
11MP:00107686.8CFC1, GATA4, GATA6, GDF1, MED24, NKX2-5

Publications for Transposition of the Great Arteries

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Articles related to Transposition of the Great Arteries:

(show top 50)    (show all 714)
idTitleAuthorsYear
1
Palliative Arterial Switch for Congenitally Corrected Transposition of the Great Arteries with Ventricular Septal Defect and Subaortic Hypoplasia. (26498996)
2015
2
Anesthetic Considerations and Management of Transposition of the Great Arteries. (25900898)
2015
3
Juxtaposed right atrial appendage in complex Transposition of the Great Arteries. (25583626)
2015
4
Pulmonary Interstitial Glycogenosis: A Reversible Underlying Condition Associated With D-Transposition of the Great Arteries and Severe Persistent Pulmonary Hypertension. (26180171)
2015
5
Editorial comment: the use of veno-venous extracorporeal membrane oxygenation for perinatal support of an infant with d-transposition of the great arteries, intact atrial and ventricular septa, and flow-restricted ductus arteriosus. (25611995)
2014
6
Successful biventricular repair of double-outlet right ventricle with transposition of the great arteries, pulmonary stenosis, and straddling mitral valve. (24694423)
2014
7
Earlier Arterial Switch Operation Improves Outcomes and Reduces Costs for Neonates with Transposition of the Great Arteries. (24184243)
2013
8
The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle. (23427188)
2013
9
Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. (23331588)
2012
10
Autonomic nervous system function in infants with transposition of the great arteries. (21613339)
2012
11
Complete atrioventricular block in an adult with congenitally corrected transposition of the great arteries with interrupted inferior vena cava. (23798952)
2012
12
Atrioventricular node reentrant tachycardia in patients with congenitally corrected transposition of the great arteries and results of radiofrequency catheter ablation. (23159417)
2012
13
Long-term prognosis of double-switch operation for congenitally corrected transposition of the great arteries. (22551964)
2012
14
Percutaneous edge-to-edge repair of tricuspid regurgitation in congenitally corrected transposition of the great arteries. (21269414)
2011
15
Perioperative care of a child with transposition of the great arteries. (21706195)
2011
16
The modified Senning procedure as an integral part of an anatomical correction of congenitally corrected transposition of the great arteries. (24414198)
2011
17
Editorial comment Corrected transposition of the great arteries: is 'anatomic' repair the optimal option? (21515064)
2011
18
The role of the Fontan operation in the treatment of congenitally corrected transposition of the great arteries. (21976866)
2011
19
Long-term outcomes after an arterial switch operation for simple complete transposition of the great arteries. (20111649)
2010
20
Do predictors exist for a successful withdrawal of preoperative prostaglandin E(1) from neonates with d-transposition of the great arteries and intact ventricular septum? (20886209)
2010
21
The right ventricular response to high afterload: comparison between healthy persons and patients with transposition of the great arteries: a 2D strain study. (20618391)
2010
22
Congenitally corrected transposition of the great arteries presenting in a nonagenarian. (20805436)
2010
23
A case of platypnea-orthodeoxia syndrome caused by the interaction between the presence of corrected transposition of the great arteries and patent foramen ovale. (18706706)
2010
24
A reminder from the past: a 49-year-old patient with transposition of the great arteries palliated with Dr. Thomas Baffes' and Dr. William Mustard's original operations. (19647403)
2009
25
Congenitally corrected transposition of the great arteries plus dextrocardia operated with an unusual operative technique. (18704862)
2008
26
Enlarged bronchial collateral artery complicating recovery after arterial switch for simple transposition of the great arteries. (18757452)
2008
27
Intraoperative coronary artery pulse Doppler patterns in patients with complete transposition of the great arteries undergoing the arterial switch operation. (18760127)
2008
28
Double aortic arch and d-transposition of the great arteries. (18186786)
2008
29
Cardiac defibrillation therapy for at risk patients with systemic right ventricular dysfunction secondary to atrial redirection surgery for dextro-transposition of the great arteries. (17383987)
2007
30
Metabolic alterations and neurodevelopmental outcome of infants with transposition of the great arteries. (16897317)
2006
31
That balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries is another powerful argument in favor of therapeutic closure of every patent foramen ovale. (16828611)
2006
32
Primary surgical correction of transposition of the great arteries and atrioventricular septal defect associated with left isomerism. (16391973)
2006
33
A case of transposition of the great arteries in a female infant of a HIV-1-infected woman. Potential teratogenic effects of antiretroviral drugs. (16941823)
2006
34
Ablation of atrioventricular conduction in corrected transposition of the great arteries. (16648068)
2006
35
Successful repair of transposition of the great arteries with right aortic arch and coarctation of the aorta. (16482932)
2006
36
Relation between right ventricular structural alterations and markers of adverse clinical outcome in adults with systemic right ventricle and either congenital complete (after Senning operation) or congenitally corrected transposition of the great arteries. (17056346)
2006
37
Arterial switch operation for transposition of the great arteries combined with closure of paramembranous ventricular septal defect using the Amplatzer membranous ventricular septal occluder. (16098318)
2005
38
Late outcome of Senning and Mustard procedures for correction of transposition of the great arteries. (15831655)
2005
39
Repair of transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction. (15082275)
2004
40
Combined arterial switch and Senning operation for congenitally corrected transposition of the great arteries: patient selection and intermediate results. (12658191)
2003
41
Neurocutaneous melanosis with transposition of the great arteries and renal agenesis. (12869156)
2003
42
Apico-pulmonary artery conduit repair of congenitally corrected transposition of the great arteries with ventricular septal defect and pulmonary outflow tract obstruction: a 10-year follow-up. (14602256)
2003
43
Outcome of 121 patients with congenitally corrected transposition of the great arteries. (11889523)
2002
44
Congenitally corrected transposition of the great arteries in a 65-year-old woman. (11804307)
2001
45
Transposition of the great arteries, pulmonary atresia, and multiple ventricular septal defects associated with multiple cardiac rhabdomyomas in a case of tuberous sclerosis. (10754091)
2000
46
Systemic ventricular inflow obstruction in congenitally corrected transposition of the great arteries. (9130433)
1997
47
Congenitally corrected transposition of the great arteries in the adult: functional status and complications. (8609349)
1996
48
Congenitally corrected transposition of the great arteries and exercise-induced ventricular tachycardia. (8640601)
1996
49
Tricuspid atresia with transposition of the great arteries in adolescents and adults: current state and late complications. (3342144)
1988
50
The Mustard procedure in transposition of the great arteries associated with juxtaposition of the atrial appendages with and without dextrocardia. (6827853)
1983

Variations for Transposition of the Great Arteries

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Expression for genes affiliated with Transposition of the Great Arteries

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Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

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GO Terms for genes affiliated with Transposition of the Great Arteries

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Cellular components related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor complexGO:00905759.8GATA4, NKX2-5

Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:005501410.7NKX2-5, NKX2-6
2right ventricular cardiac muscle tissue morphogenesisGO:000322110.7NKX2-5, ZFPM2
3ventricular cardiac muscle cell developmentGO:005501510.5NKX2-5, NKX2-6
4ventricular septum morphogenesisGO:006041210.5NKX2-5, ZFPM2
5lymph vessel developmentGO:000194510.5NR2F2, TBX1
6cardiac ventricle morphogenesisGO:000320810.5GATA4, NKX2-5
7regulation of cardiac muscle cell proliferationGO:006004310.5GATA4, NKX2-5
8cellular response to gonadotropin stimulusGO:007137110.4GATA4, GATA6
9positive regulation of cardiac muscle cell proliferationGO:006004510.3GATA4, GATA6
10pharyngeal system developmentGO:006003710.3NKX2-5, NKX2-6, TBX1
11tube morphogenesisGO:003523910.3GATA4, GATA6
12cardiac muscle hypertrophy in response to stressGO:001489810.2GATA4, GATA6
13intestinal epithelial cell differentiationGO:006057510.2GATA4, GATA6
14atrial septum morphogenesisGO:006041310.2GATA4, NKX2-5
15thyroid gland developmentGO:003087810.2NKX2-5, TBX1
16positive regulation of BMP signaling pathwayGO:003051310.1GATA4, GATA6
17embryonic heart tube developmentGO:003505010.1GATA4, NKX2-5, NKX2-6
18endocardial cushion developmentGO:000319710.1CRELD1, GATA4
19cardiac septum developmentGO:000327910.1CRELD1, GATA4
20positive regulation of cardioblast differentiationGO:005189110.1GATA4, GATA6, NKX2-5
21anterior/posterior pattern specificationGO:000995210.1NR2F2, TBX1, ZIC3
22heart loopingGO:000194710.1GATA4, NKX2-5, ZIC3
23cardiac muscle cell differentiationGO:005500710.0GATA4, GATA6, NKX2-5
24blood vessel morphogenesisGO:004851410.0NR2F2, TBX1
25outflow tract septum morphogenesisGO:000314810.0GATA6, NKX2-5, TBX1, ZFPM2
26cell developmentGO:00484689.9GATA4, GATA6, GDF1
27response to vitamin AGO:00331899.9GATA4, PITX2
28BMP signaling pathwayGO:00305099.9GATA4, GDF1, NKX2-5
29cardiac muscle tissue developmentGO:00487389.8GATA4, GATA6, NKX2-5, ZFPM2
30heart morphogenesisGO:00030079.7GATA4, NKX2-5, TBX1
31in utero embryonic developmentGO:00017019.5GATA4, GATA6, NR2F2, ZFPM2
32determination of left/right symmetryGO:00073689.5CFC1, PITX2, TBX1, ZIC3
33heart developmentGO:00075079.1GATA4, NKX2-5, NKX2-6, TBX1, ZFPM2
34male gonad developmentGO:00085849.0GATA4, GATA6, PITX2
35negative regulation of transcription from RNA polymerase II promoterGO:00001228.9GATA6, NKX2-5, NR2F2, PITX2, ZFPM2
36positive regulation of transcription from RNA polymerase II promoterGO:00459448.2GATA4, GATA6, NKX2-5, PITX2, TBX1, ZFPM2
37transcription from RNA polymerase II promoterGO:00063668.2GATA4, GATA6, MED24, NKX2-5, PITX2, ZIC3
38positive regulation of transcription, DNA-templatedGO:00458938.1GATA4, GATA6, MED24, NKX2-5, NR2F2, TBX1
39regulation of transcription from RNA polymerase II promoterGO:00063578.1GATA4, MED13L, MED24, NKX2-5, NR2F2, PITX2

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:000110410.1MED13L, MED24, NKX2-5
2transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370510.0GATA4, GATA6, NKX2-5
3RNA polymerase II transcription factor bindingGO:00010859.6GATA4, GATA6, PITX2, ZFPM2
4RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.6GATA4, NKX2-5, PITX2, ZIC3
5transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.3GATA4, GATA6, NKX2-5
6transcription factor bindingGO:00081348.9GATA4, GATA6, NKX2-5, PITX2, ZFPM2
7sequence-specific DNA bindingGO:00435657.9GATA4, GATA6, NKX2-5, NKX2-6, NR2F2, PITX2
8DNA bindingGO:00036777.9GATA4, GATA6, NKX2-5, NKX2-6, NR2F2, PITX2
9transcription factor activity, sequence-specific DNA bindingGO:00037007.6GATA4, GATA6, NKX2-5, NKX2-6, NR2F2, PITX2

Sources for Transposition of the Great Arteries

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
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42NCIt
43NDF-RT
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47Novoseek
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50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet