TGA
MCID: TRN044
MIFTS: 36

Transposition of the Great Arteries (TGA) malady

Summaries for Transposition of the Great Arteries

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to ventricular septal defect and situs inversus. An important gene associated with Transposition of the Great Arteries is MED13L (mediator complex subunit 13-like), and among its related pathways are Signaling by NODAL and HOP Signaling. The compounds candoxatril and celiprolol have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and skin, and related mouse phenotypes are digestive/alimentary and skeleton.

Wikipedia:64 Transposition of the great vessels (TGV) is a group of congenital heart defects involving an abnormal... more...

Aliases & Classifications for Transposition of the Great Arteries

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Aliases & Descriptions:

transposition of the great arteries 43
transposition of the great arteries, dextro-looped 1 61
dextro-looped transposition of the great arteries 43
dtga 43
tga 43


Related Diseases for Transposition of the Great Arteries

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1ventricular septal defect31.7NKX2-5, GATA4, NPPB
2situs inversus31.3GDF1, CCDC11, ZIC3
3atrioventricular block30.7NPPB, GATA4, NKX2-5
4atrioventricular septal defect30.6NKX2-5, CRELD1, GATA4
5acute myocardial infarction29.9ACE, NPPB
6left ventricular outflow tract obstruction11.0
7congenitally corrected transposition of the great arteries10.9
8dextrocardia10.8
9tricuspid atresia10.8
10aortopulmonary window10.7
11aortic coarctation10.6
12subpulmonary stenosis10.6
13hypoplastic left heart syndrome10.6
14n syndrome10.6
15vascular disease10.6
16transposition of the great arteries, dextro-looped 210.6
17transposition of the great arteries, dextro-looped 110.6
18ebstein anomaly10.5
19patent foramen ovale10.5
20complete atrioventricular canal10.5
21brain injury10.5
22wolff-parkinson-white syndrome10.4
23tuberous sclerosis10.4
24cor triatriatum10.4
25pulmonary vein stenosis10.4
26transposition of great arteries, dextro-looped 310.4
27isolated congenitally uncorrected transposition of the great arteries10.4
28congenitally uncorrected transposition of the great arteries with cardiac malformation10.4
29criss-cross heart10.4
30congenitally uncorrected transposition of the great arteries with coarctation10.4
31accessory mitral valve tissue10.4
32transient global amnesia10.4
33coronary artery disease,10.3
34marfan syndrome10.3
35subclavian steal syndrome10.3
36congenital heart block10.3
37klinefelter's syndrome10.3
38biliary atresia10.3
39renal agenesis10.3
40tricuspid valve insufficiency10.3
41tricuspid valve stenosis10.3
42endocardial fibroelastosis10.3
43citrullinemia10.3
44scimitar syndrome10.3
45intestinal atresia10.3
46imperforate anus10.3
47glucocorticoid-remediable aldosteronism10.3
48conn's syndrome10.3
49sick sinus syndrome10.3
50congenital diaphragmatic hernia10.3

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Clinical Features for Transposition of the Great Arteries

Drugs & Therapeutics for Transposition of the Great Arteries

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Transposition of the Great Arteries

Drug clinical trials:

Search ClinicalTrials for Transposition of the Great Arteries

Search NIH Clinical Center for Transposition of the Great Arteries

Search CenterWatch for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

Anatomical Context for Transposition of the Great Arteries

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Transposition of the Great Arteries:

33
Heart, Lung, Skin

Animal Models for Transposition of the Great Arteries or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Transposition of the Great Arteries

Genetic Variations for Transposition of the Great Arteries

Expression for genes affiliated with Transposition of the Great Arteries

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Transposition of the Great Arteries

Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CFC1, GDF1
29.8GATA4, NKX2-5
39.5NKX2-5, PITX2, GATA4
4
Hide members
9.4NKX2-5, GATA4, NPPB
59.4NKX2-5, GATA4, NPPB

Compounds for genes affiliated with Transposition of the Great Arteries

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1candoxatril45 1110.9NPPB, ACE
2celiprolol459.9NPPB, ACE
3alacepril459.9NPPB, ACE
4imidapril459.9ACE, NPPB
5trandolapril45 1110.9NPPB, ACE
6bisoprolol45 50 1111.9NPPB, ACE
7fosinopril45 1110.9ACE, NPPB
8moxonidine459.9ACE, NPPB
9enalaprilat459.9NPPB, ACE
10lisinopril45 11 2411.8ACE, NPPB
11metoprolol45 29 50 11 2413.8ACE, NPPB
12ramipril45 1110.7NPPB, ACE
13taurolidine459.7IL6, ANXA5
14atenolol45 29 50 11 2413.6ACE, NPPB
15telmisartan45 29 1111.6ACE, NPPB
16tirofiban45 1110.6NPPB, ANXA5
17valsartan45 60 29 1112.5NPPB, ACE
18perindopril45 50 1111.3ACE, NPPB
19zinc45 249.9ZIC3, NPPB, GATA4, NKX2-5, ACE
20nitric oxide45 11 2410.6NPPB, GATA4, NKX2-5, IL6, ACE

GO Terms for genes affiliated with Transposition of the Great Arteries

Sources:
16Gene Ontology
See all sources

Biological processes related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:05501410.2NKX2-6, NKX2-5
2pulmonary myocardium developmentGO:00335010.1NKX2-5, PITX2
3positive regulation of cardioblast differentiationGO:05189110.0NKX2-5, GATA4
4endocardial cushion developmentGO:00319710.0GATA4, CRELD1
5atrial septum morphogenesisGO:06041310.0GATA4, NKX2-5
6embryonic heart tube developmentGO:0350509.9NKX2-6, NKX2-5
7determination of left/right symmetryGO:0073689.9ZIC3, PITX2, CFC1
8ventricular cardiac muscle cell developmentGO:0550159.8NKX2-6, NKX2-5, PITX2
9ventricular septum morphogenesisGO:0604129.8NKX2-5, PITX2
10heart loopingGO:0019479.8NKX2-5, GATA4, ZIC3
11pharyngeal system developmentGO:0600379.8NKX2-5, NKX2-6
12regulation of vasodilationGO:0423129.7ACE, NPPB
13embryonic digestive tract morphogenesisGO:0485579.5PITX2, GATA4
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.8ZIC3, GATA4, PITX2, NKX2-5, IL6
15positive regulation of transcription, DNA-dependentGO:0458938.7ZIC3, GATA4, MED24, NKX2-5, IL6

Molecular functions related to Transposition of the Great Arteries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:0011049.1NKX2-5, MED13L, MED24
2sequence-specific DNA binding transcription factor activityGO:0037008.9NKX2-6, NKX2-5, PITX2, GATA4, ZIC3

Products for genes affiliated with Transposition of the Great Arteries

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Transposition of the Great Arteries

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet