MCID: TRN044
MIFTS: 47

Transposition of the Great Arteries malady

Category: Rare diseases

Aliases & Classifications for Transposition of the Great Arteries

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Aliases & Descriptions for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 48 27
Transposition of the Great Arteries, Dextro-Looped 1 68
Dextro-Looped Transposition of the Great Arteries 48
 
Dtga 48
Tga 48

Classifications:



Summaries for Transposition of the Great Arteries

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NIH Rare Diseases:48 Transposition of the great arteries (TGA) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. The aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. Symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). The exact cause of TGA in most cases is unknown. Surgery is done to correct the abnormality during the first few days of life. Last updated: 6/27/2011

MalaCards based summary: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to azygos continuation of the inferior vena cava and intestinal atresia. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. Affiliated tissues include heart, brain and testes, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Related Diseases for Transposition of the Great Arteries

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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1azygos continuation of the inferior vena cava29.8CRELD1, GATA4
2intestinal atresia29.6GATA4, NR2F2, ZFPM2
3congenitally corrected transposition of the great arteries12.7
4transposition of the great arteries, dextro-looped 112.6
5transposition of the great arteries, dextro-looped 212.5
6isolated congenitally uncorrected transposition of the great arteries12.2
7congenitally uncorrected transposition of the great arteries with cardiac malformation12.2
8congenitally uncorrected transposition of the great arteries with coarctation12.2
9transposition of great arteries, dextro-looped 312.1
10conotruncal heart malformations11.7
11transient global amnesia11.6
12congenital heart defects, multiple types, 411.0
13heterotaxy, visceral, 6, autosomal recessive11.0
14heterotaxy, visceral, 1, x-linked11.0
15mental retardation and distinctive facial features with or without cardiac defects11.0
16ventricular septal defect10.7
17left ventricular outflow tract obstruction10.5
18dextrocardia10.4
19pulmonary hypertension10.3
20suppurative cholangitis10.3GDF1, NKX2-6
21otosclerosis 110.3MIR1469, NR2F2
22undifferentiated carcinoma of the corpus uteri10.3CFC1, GDF1, MED13L
23tricuspid atresia10.3
24esophageal atresia10.2NKX2-6, ZFPM2
25radioulnar synostosis10.2MIR1469, NR2F2, ZIC3
26aortopulmonary window10.2
27uniparental disomy of chromosome 1110.2GATA6, NR2F2, ZIC3
28tetralogy of fallot10.2
29heart disease10.2
30aneurysm10.2
31hhv-6 encephalitis10.1CFAP53, CFC1, ZIC3
32cor triatriatum10.1
33subpulmonary stenosis10.1
34drug-induced vasculitis10.1GATA4, ZFPM2
35univentricular heart with single atrio-ventricular valve10.1CRELD1, GATA4
36hypoplastic left heart syndrome10.1
37atrioventricular block10.1
38right aortic arch10.1
396-phosphogluconate dehydrogenase deficiency10.1GATA4, NKX2-5, NKX2-6
40cataract 17, multiple types10.1GDF1, NKX2-6, TBX1
41trophoblastic neoplasm10.0CRELD1, ZIC3
42myocardial infarction10.0
43brain injury10.0
44atrioventricular septal defect10.0
45patent foramen ovale10.0
46congenital diaphragmatic hernia10.0
47aortic coarctation10.0
48sudden cardiac death10.0
49criss-cross heart10.0
50wolff-parkinson-white syndrome9.9

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Symptoms & Phenotypes for Transposition of the Great Arteries

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MGI Mouse Phenotypes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

41 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.4GATA4, GATA6, GDF1, PITX2, ZFPM2, ZIC3
2MP:00053719.1ANXA5, GATA4, GATA6, PITX2, TBX1, ZIC3
3MP:00053698.6GATA4, GATA6, MED24, NKX2-5, NR2F2, PITX2
4MP:00053808.2GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
5MP:00053848.2GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
6MP:00053788.2GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
7MP:00053978.1ANXA5, GATA4, GATA6, GDF1, MED24, NKX2-5
8MP:00028737.9ANXA5, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
9MP:00053857.9GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
10MP:00107687.9GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
11MP:00053887.9GATA4, GATA6, GDF1, NKX2-5, NKX2-6, PITX2

Drugs & Therapeutics for Transposition of the Great Arteries

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Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactoneapprovedPhase 42221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2
MechlorethamineapprovedPhase 437751-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
 
KBioGR_001448
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
3
EplerenoneapprovedPhase 494107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
4Mineralocorticoid Receptor AntagonistsPhase 4333
5MineralocorticoidsPhase 4352
6diureticsPhase 41372
7Natriuretic AgentsPhase 41645
8Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
9Diuretics, Potassium SparingPhase 41827
10Hormone AntagonistsPhase 412778
11HormonesPhase 413979
12
AcetylcysteineapprovedPhase 2316616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
13Pharmaceutical SolutionsPhase 27793
14ExpectorantsPhase 2388
15Respiratory System AgentsPhase 24818
16Blood SubstitutesPhase 2246
17Antiviral AgentsPhase 29732
18Plasma SubstitutesPhase 2233
19DextransPhase 299
20AnticoagulantsPhase 22516
21N-monoacetylcystinePhase 2316
22Protective AgentsPhase 27190
23Phosphodiesterase InhibitorsPhase 21254
24AntioxidantsPhase 22928
25SimendanPhase 255
26Anti-Arrhythmia AgentsPhase 22969
27Vasodilator AgentsPhase 23438
28Anti-Infective AgentsPhase 221402
29AntidotesPhase 21038
30HematinicsPhase 1, Phase 21630
31Epoetin alfaPhase 1, Phase 2645113427-24-0
32
Dexmedetomidineapproved, vet_approvedPhase 154076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
33Neurotransmitter AgentsPhase 117734
34Adrenergic AgentsPhase 15140
35Central Nervous System DepressantsPhase 112806
36Hypnotics and SedativesPhase 12485
37Peripheral Nervous System AgentsPhase 122776
38Adrenergic AgonistsPhase 12877
39Analgesics, Non-NarcoticPhase 16260
40Adrenergic alpha-AgonistsPhase 11625
41Adrenergic alpha-2 Receptor AgonistsPhase 1911
42AnalgesicsPhase 111287
43
Dobutamineapproved11434368-04-236811
Synonyms:
(+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
(+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
34368-04-2
34368-04-2 (Parent)
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
52663-81-7 (hydrochloride)
74753-15-4
74753-15-4 (hydrobromide)
AC1L1WFF
AC1Q7AD1
BPBio1_000489
BRD-A78322124-003-03-3
BSPBio_000443
C06967
CHEBI:4670
CHEMBL926
CID36811
D03879
DB00841
DL-Dobutamine
DL-dobutamine
Dobutamin
Dobutamina
Dobutamina [INN-Spanish]
Dobutamine
Dobutamine (USP/INN)
Dobutamine Hcl
Dobutamine Hcl in Dextrose 5%
 
Dobutamine Hydrochloride
Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer
Dobutamine [USAN:BAN:INN]
Dobutamine [USAN]
Dobutamine [Usan:Ban:Inn]
Dobutamine [Usan]
Dobutamine hydrobromide
Dobutaminum
Dobutaminum [INN-Latin]
Dobutrex
EINECS 277-982-4
HMS2089K05
Inotrex
L001157
LS-174467
LY 81929
Lilly 81929
Lopac0_000365
NCGC00015321-05
NCGC00024629-02
NCGC00024629-03
Prestwick0_000352
Prestwick1_000352
Prestwick2_000352
Prestwick3_000352
Racemic-Dobutamine
Racemic-dobutamine
SPBio_002364
UNII-0WR771DJXV
UNII-3S12J47372
dobutamine
dobutamine(usp)
rac-Dobutamine
rac-dobutamine
racemic-Dobutamine
44Adrenergic Antagonists1535
45Adrenergic beta-Antagonists1154

Interventional clinical trials:

(show all 35)
idNameStatusNCT IDPhase
1Eplerenone in Systemic Right VentricleCompletedNCT00703352Phase 4
2The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseTerminatedNCT01971593Phase 4
3Comparison of Hematocrit Levels in Infant Heart SurgeryCompletedNCT00006183Phase 3
4Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
5Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve DysfunctionRecruitingNCT02744677Phase 3
6Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 2
7N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)CompletedNCT00374088Phase 2
8Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
9Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
10A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
11MRI Study After Arterial Switch Operation in Patients With Transposition of the Great ArteriesCompletedNCT01916499
12Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular FunctionCompletedNCT00313352
13CT Coronary Angiography After Arterial Switch OperationCompletedNCT01153776
14Physical Training in Transposition of the Great ArteriesCompletedNCT00837603
15Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) FindingsCompletedNCT01430897
16Myocardial Contrast Echocardiography in Congenital Heart DiseaseCompletedNCT00412685
17Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic MethodsCompletedNCT01907971
18Quality of Life in Young Adults With Congenital Heart DiseaseCompletedNCT02463292
19Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental OutcomeCompletedNCT00713635
20Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
21Genes Causing Ebstein's AnomalyCompletedNCT00497705
22A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
23Fibrosis, Valvular and Ventricular Function in Patients With TGARecruitingNCT02588989
24Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young AdultsRecruitingNCT02415491
25Genetic Determinants of Congenital Heart Disease OutcomesRecruitingNCT01656941
26Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic ResonanceRecruitingNCT02161471
27Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)RecruitingNCT02184169
28Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults.RecruitingNCT02542345
29Assessing Neurodevelopment in Congenital Heart Disease.RecruitingNCT02996630
30T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart DiseaseRecruitingNCT02350829
31Surgical Planning for Reconstruction of Complex Heart DefectsRecruitingNCT00972608
32National Congenital Heart Disease AuditRecruitingNCT02303535
33Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract ReconstructionActive, not recruitingNCT02700100
34Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility StudyNot yet recruitingNCT03022708
35Trial Comparing One-stage With Two-stage Basilic Vein TranspositionTerminatedNCT01274117

Search NIH Clinical Center for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

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Genetic tests related to Transposition of the Great Arteries:

id Genetic test Affiliating Genes
1 Transposition of Great Arteries27
2 Transposition of the Great Arteries27

Anatomical Context for Transposition of the Great Arteries

About this section

MalaCards organs/tissues related to Transposition of the Great Arteries:

36
Heart, Brain, Testes, Liver, Pituitary, Atrioventricular node

Publications for Transposition of the Great Arteries

About this section

Articles related to Transposition of the Great Arteries:

(show top 50)    (show all 789)
idTitleAuthorsYear
1
Mid-term Outcomes in Patients with Congenitally Corrected Transposition of the Great Arteries: A Single Center Experience. (28088601)
2017
2
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation. (28057382)
2017
3
Play the Map: Ablation of a Macro Reentrant Atrial Tachycardia in a Patient After Senning Repair for Transposition of the Great Arteries. (28045674)
2017
4
The use of contrast echo to detect shunts at atrial level in a Mustard or Senning repair for transposition of the great arteries: you can teach an old dog new tricks. (28065912)
2017
5
Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum. (28077506)
2017
6
Transposition of the Great Arteries in the Developing World: Surgery and Outcomes. (28057249)
2017
7
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries. (28064156)
2017
8
Transposition of the great arteries: Rationale for tailored preoperative management. (28024917)
2016
9
Longitudinal strain of systemic right ventricle correlates with exercise capacity in adult with transposition of the great arteries after atrial switch. (27179205)
2016
10
Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation. (27847084)
2016
11
Assessment of myocardial function using MRI-based feature tracking in adults after atrial repair of transposition of the great arteries: Reference values and clinical utility. (27389449)
2016
12
Single coronary" in transposition of the great arteries: Why are we still talking about it? (27131848)
2016
13
Reoperations and catheter interventions in patients with transposition of the great arteries after the arterial switch operation. (27615267)
2016
14
Acute myocardial infarction with isolated congenitally corrected transposition of the great arteries. (27034557)
2016
15
Mechanisms and predictors of recurrent tachycardia after catheter ablation for d-transposition of the great arteries after the Mustard or Senning operation. (27908766)
2016
16
Percutaneous tricuspid valve repair using MitraClipAr for the treatment of severe tricuspid valve regurgitation in a patient with congenitally corrected transposition of the great arteries. (27412162)
2016
17
Multimodality Imaging Guidelines of Patients with Transposition of the Great Arteries: A Report from the American Society of Echocardiography Developed inA Collaboration with the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. (27372954)
2016
18
Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome. (27892741)
2016
19
Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography. (27659876)
2016
20
Echocardiography vs magnetic resonance imaging in assessing ventricular function and systemic atrioventricular valve status in adults with congenitally corrected transposition of the great arteries. (27542349)
2016
21
MelodyAr pulmonary valve implantation in two teenage patients with congenitally corrected transposition of the great arteries status after Senning atrial switch operation. (27748225)
2016
22
Isolated congenitally corrected transposition of the great arteries with dextroversion discovered incidentally in a patient with cocaine-induced acute myocardial infarction. (27034558)
2016
23
Long-term results after physiologic repair for congenitally corrected transposition of the great arteries. (27431990)
2016
24
Use of the total artificial heart as a bridge to transplant in a 13-year-old with congenitally corrected transposition of the great arteries. (26707764)
2016
25
Mapping and ablation of anteroseptal atrial tachycardia in patients with congenitally corrected transposition of the great arteries: implication of pulmonary sinus cusps. (27965318)
2016
26
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries). (27401272)
2016
27
Aortic Translocation for Repair of Transposition of the Great Arteries (S,D,L) With Ventricular Septal Defect and Pulmonic Stenosis. (26694279)
2016
28
Sudden cardiac death in adults with congenitally corrected transposition of the great arteries. (27493760)
2016
29
Radiofrequency Catheter Ablation of Orthodromic Atrioventricular Reentrant Tachycardia in a Child with Congenitally Corrected Transposition of the Great Arteries and Atrial Septal Defect. (27057934)
2016
30
Pulmonary Arterial Hypertension and Neonatal Arterial Switch Surgery for Correction of Transposition of the Great Arteries. (27156642)
2016
31
Hybrid stenting for left ventricular outflow tract obstruction in congenitally corrected transposition of the great arteries. (27938457)
2016
32
Management of congenital diaphragmatic hernia with transposition of the great arteries. (27073102)
2016
33
Current mid-term outcome with an integrated surgical strategy for correction of d-transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction. (27009103)
2016
34
Prenatal Echocardiographic Assessment of Foramen Ovale Appearance in Fetuses with D-Transposition of the Great Arteries and Impact on Neonatal Outcome. (27654925)
2016
35
Severe Pulmonary Vascular Obstructive Disease After Neonatal Arterial Switch Operation for Simple Transposition of the Great Arteries. (27098605)
2016
36
Criss-cross heart with dextrocardia and transposition of the great arteries: a rare pathology. (26875142)
2016
37
Atrial tachyarrhythmias after atrial switch operation for transposition of the great arteries: Treating old surgery with new catheters. (27018378)
2016
38
Major Aortopulmonary Collaterals in Transposition of the Great Arteries: A Cause for Preoperative and Postoperative Hemodynamic Imbalance. (27343525)
2016
39
New coronary transfer technique for transposition of the great arteries with a single coronary artery. (27998606)
2016
40
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction. (27130951)
2016
41
Children and Adolescents Show Altered Visual Working Memory Related Brain Activity More Than One Decade After Arterial Switch Operation for D-Transposition of the Great Arteries. (27918206)
2016
42
Long-Term Follow-Up of the Half-Turned Truncal Switch Operation for Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis. (27064891)
2016
43
When left turns to right: a congenital corrected transposition of the great arteries with an azygos continuation without another major cardiac abnormality. (27401820)
2016
44
Hemodynamic consequences of a restrictive ductus arteriosus and foramen ovale in fetal transposition of the great arteries. (27589547)
2016
45
Double Switch Procedure and Surgical Alternatives for the Treatment of Congenitally Corrected Transposition of the Great Arteries. (26956686)
2016
46
Cardiac output and blood flow redistribution in the fetus with D-loop transposition of the great arteries and intact ventricular septum: insights into the pathophysiology. (27873373)
2016
47
In situ reconstruction using the half-ring-shaped aortic wall for transposition of the great arteries. (27064080)
2016
48
Left Ventricular Function after Arterial Switch Operation as Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Patients with Simple Transposition of the Great Arteries. (27956909)
2016
49
Internal Cardioverter Defibrillator Indications and Therapies after Atrial Baffle Procedure for d-Transposition of the Great Arteries: A Multicenter Analysis. (27503213)
2016
50
Transposition of the Great Arteries and Common Variants. (27490620)
2016

Variations for Transposition of the Great Arteries

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Expression for genes affiliated with Transposition of the Great Arteries

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Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

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Pathways related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8GATA4, NKX2-5
29.8GATA4, NKX2-5
39.3GATA4, MED13L, MED24
48.9GATA4, GATA6, NKX2-5, PITX2, TBX1

GO Terms for genes affiliated with Transposition of the Great Arteries

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Cellular components related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056345.3ANXA5, GATA4, GATA6, MED24, MIR1469, MIR423

Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1atrial cardiac muscle cell developmentGO:005501410.7NKX2-5, NKX2-6
2embryonic heart tube developmentGO:003505010.7NKX2-5, NKX2-6
3thyroid gland developmentGO:003087810.7NKX2-5, TBX1
4right ventricular cardiac muscle tissue morphogenesisGO:000322110.7NKX2-5, ZFPM2
5positive regulation of cardiac muscle cell proliferationGO:006004510.6GATA6, ZFPM2
6pulmonary myocardium developmentGO:000335010.6NKX2-5, PITX2
7atrial septum morphogenesisGO:006041310.6GATA4, NKX2-5
8cardiac ventricle morphogenesisGO:000320810.6GATA4, NKX2-5
9intestinal epithelial cell differentiationGO:006057510.5GATA4, GATA6
10pharyngeal system developmentGO:006003710.5NKX2-5, NKX2-6, TBX1
11endocardial cushion developmentGO:000319710.4CRELD1, GATA4
12lung developmentGO:003032410.4PITX2, ZFPM2, ZIC3
13heart loopingGO:000194710.3GATA4, NKX2-5, ZIC3
14response to vitamin AGO:003318910.3GATA4, PITX2
15cell developmentGO:004846810.3GATA4, GATA6, GDF1
16positive regulation of cardioblast differentiationGO:005189110.2GATA4, GATA6, NKX2-5
17outflow tract septum morphogenesisGO:000314810.2GATA6, NKX2-5, TBX1, ZFPM2
18maternal placenta developmentGO:000189310.2MIR1469, NR2F2
19negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:004573610.2MIR1469, NR2F2
20negative regulation of endothelial cell migrationGO:001059610.2MIR1469, NR2F2
21placenta blood vessel developmentGO:006067410.2MIR1469, NR2F2
22positive regulation of systemic arterial blood pressureGO:000308410.2MIR1469, NR2F2
23radial pattern formationGO:000995610.1MIR1469, NR2F2
24male gonad developmentGO:000858410.1GATA4, GATA6, PITX2
25regulation of transcription involved in lymphatic endothelial cell fate commitmentGO:006084910.1MIR1469, NR2F2
26determination of left/right symmetryGO:000736810.1CFC1, PITX2, TBX1, ZIC3
27cardiac muscle tissue developmentGO:004873810.1GATA6, NKX2-5, PITX2, ZFPM2
28vasculogenesisGO:000157010.0NKX2-5, PITX2, ZFPM2
29ventricular cardiac muscle cell developmentGO:005501510.0NKX2-5, NKX2-6, PITX2
30blood vessel morphogenesisGO:00485149.9MIR1469, NR2F2, TBX1
31lymph vessel developmentGO:00019459.9MIR1469, NR2F2, TBX1
32trophoblast giant cell differentiationGO:00607079.9MIR1469, NR2F2
33cardiac muscle cell differentiationGO:00550079.9GATA4, GATA6, NKX2-5, PITX2
34heart developmentGO:00075079.8NKX2-5, NKX2-6, PITX2, TBX1, ZFPM2
35neuron migrationGO:00017649.8MIR1469, NR2F2, PITX2
36anterior/posterior pattern specificationGO:00099529.7MIR1469, NR2F2, TBX1, ZIC3
37skeletal muscle tissue developmentGO:00075199.7MIR1469, NR2F2, PITX2
38ventricular septum morphogenesisGO:00604129.6NKX2-5, PITX2, ZFPM2
39blood coagulationGO:00075969.6ANXA5, GATA4, GATA6, ZFPM2
40negative regulation of transcription, DNA-templatedGO:00458929.3GATA6, MIR1469, NKX2-5, NR2F2, ZFPM2
41in utero embryonic developmentGO:00017019.2GATA6, MIR1469, NR2F2, PITX2, ZFPM2
42positive regulation of transcription from RNA polymerase II promoterGO:00459449.1GATA4, GATA6, NKX2-5, PITX2, TBX1, ZFPM2
43transcription from RNA polymerase II promoterGO:00063668.9GATA4, GATA6, MED24, NKX2-5, PITX2, ZIC3
44regulation of transcription from RNA polymerase II promoterGO:00063578.5MED13L, MED24, MIR1469, NKX2-5, NR2F2, PITX2
45positive regulation of transcription, DNA-templatedGO:00458937.5GATA4, GATA6, MED24, MIR1469, NKX2-5, NR2F2

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:000110410.3MED13L, MED24, NKX2-5
2RNA polymerase II transcription factor bindingGO:000108510.2GATA4, GATA6, ZFPM2
3retinoic acid bindingGO:000197210.1MIR1469, NR2F2
4chromatin bindingGO:00036829.9GATA4, GATA6, NKX2-5, PITX2
5transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.5GATA4, GATA6, NKX2-5
6transcription factor bindingGO:00081349.4GATA4, GATA6, NKX2-5, PITX2, ZFPM2
7DNA bindingGO:00036778.5GATA4, GATA6, MIR1469, NKX2-5, NR2F2, PITX2
8sequence-specific DNA bindingGO:00435658.0GATA4, GATA6, MIR1469, NKX2-5, NKX2-6, NR2F2
9transcription factor activity, sequence-specific DNA bindingGO:00037007.9GATA4, GATA6, MIR1469, NKX2-5, NKX2-6, NR2F2

Sources for Transposition of the Great Arteries

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
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40MESH via Orphanet
41MGI
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45NCIt
46NDF-RT
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50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet