TGA
MCID: TRN044
MIFTS: 48

Transposition of the Great Arteries (TGA) malady

Category: Rare diseases

Aliases & Classifications for Transposition of the Great Arteries

About this section

Aliases & Descriptions for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 48 27
Transposition of the Great Arteries, Dextro-Looped 1 68
Dextro-Looped Transposition of the Great Arteries 48
 
Dtga 48
Tga 48

Classifications:



Summaries for Transposition of the Great Arteries

About this section
NIH Rare Diseases:48 Transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards based summary: Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to imperforate anus and congenitally corrected transposition of the great arteries. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and HOP Signaling. Affiliated tissues include heart, skin and lung, and related mouse phenotypes are digestive/alimentary and limbs/digits/tail.

Related Diseases for Transposition of the Great Arteries

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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1imperforate anus29.6GATA4, NR2F2, ZFPM2
2congenitally corrected transposition of the great arteries12.7
3transposition of the great arteries, dextro-looped 112.6
4transposition of the great arteries, dextro-looped 212.5
5dextro-looped transposition of the great arteries12.3
6isolated congenitally uncorrected transposition of the great arteries12.2
7congenitally uncorrected transposition of the great arteries with cardiac malformation12.2
8congenitally uncorrected transposition of the great arteries with coarctation12.2
9transposition of great arteries, dextro-looped 312.1
10transient global amnesia11.8
11conotruncal heart malformations11.7
12congenital heart defects, multiple types, 411.0
13heterotaxy, visceral, 6, autosomal recessive11.0
14heterotaxy, visceral, 1, x-linked11.0
15med13l syndrome11.0
16mental retardation and distinctive facial features with or without cardiac defects11.0
17ventricular septal defect10.7
18left ventricular outflow tract obstruction10.5
19dextrocardia10.4
20situs inversus10.4
21pulmonary hypertension10.3
22tricuspid atresia10.3
23mevalonic aciduria10.2CFC1, GDF1, MED13L
24aortopulmonary window10.2
25tetralogy of fallot10.2
26heart disease10.2
27aneurysm10.2
28right inferior vena cava connecting to left-sided atrium10.2CRELD1, GATA4
29cor triatriatum10.1
30subpulmonary stenosis10.1
31left superior vena cava persisting to left-sided atrium10.1CRELD1, GATA4
32ascending cholangitis10.1GDF1, NKX2-6
33hirschsprung microcephaly cleft palate10.1CFAP53, CFC1, ZIC3
34hypoplastic left heart syndrome10.1
35atrioventricular block10.1
36right aortic arch10.1
37vulvar apocrine adenocarcinoma10.0CRELD1, GATA4, NKX2-6
38persistent eustachian valve10.0CRELD1, GATA4, GATA6
39myocardial infarction10.0
40brain injury10.0
41atrioventricular septal defect10.0
42patent foramen ovale10.0
43congenital diaphragmatic hernia10.0
44aortic coarctation10.0
45sudden cardiac death10.0
46criss-cross heart10.0
47congenital diarrhea 7 with exudative enteropathy10.0CFC1, GDF1, MED13L, NKX2-6, ZIC3
48jmp syndrome10.0CFAP53, CFC1, GDF1, PITX2, ZIC3
49wolff-parkinson-white syndrome9.9
50acute myocardial infarction9.9

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to transposition of the great arteries

Symptoms & Phenotypes for Transposition of the Great Arteries

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MGI Mouse Phenotypes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.4GATA4, GDF1, NKX2-5, NR2F2, PITX2, TBX1
2MP:00053719.4ANXA5, GATA4, GATA6, PITX2, TBX1, ZIC3
3MP:00053698.3GATA4, GATA6, MED24, NKX2-5, NR2F2, PITX2
4MP:00028738.1ANXA5, GATA4, GATA6, GDF1, NKX2-5, NKX2-6
5MP:00053847.9GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
6MP:00053807.8GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6
7MP:00053887.7GATA4, GATA6, GDF1, NKX2-5, NKX2-6, PITX2
8MP:00053857.5GATA4, GATA6, GDF1, MED24, NKX2-5, NKX2-6

Drugs & Therapeutics for Transposition of the Great Arteries

About this section

Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactoneapprovedPhase 42321952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2
EplerenoneapprovedPhase 496107724-20-9150310, 443872
Synonyms:
107724-20-9
7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
AC-4213
AC1L9FDC
C12512
CGP-30083
CHEBI:31547
CHEBI:726453
CHEMBL1095097
CID443872
D01115
Eplerenone
 
Eplerenone (JAN/USAN/INN)
Epoxymexrenone
Inspra
Inspra (TN)
Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone
MolPort-003-986-216
NCGC00159559-01
NCGC00159559-02
S1707_Selleck
SC-66110
Selara
TL8000270
ZINC03985982
3
MechlorethamineapprovedPhase 439751-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
 
KBioGR_001448
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
4Natriuretic AgentsPhase 41697
5Diuretics, Potassium SparingPhase 41917
6diureticsPhase 41418
7Hormone AntagonistsPhase 413180
8MineralocorticoidsPhase 4367
9HormonesPhase 414415
10Mineralocorticoid Receptor AntagonistsPhase 4346
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
12
Tadalafilapproved, investigationalPhase 3155171596-29-5110635
Synonyms:
(6R,12AR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
171596-29-5
1xoz
6-BENZO[1,3]dioxol-5-yl-2-methyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
AC1L380B
ADCIRCA
Acdirca
Adcirca
C429886
CHEBI:41488
CHEMBL779
CID110635
CPD000466321
Cialis
Cialis (TN)
Cialis, GF 196960, IC 351, ICOS 351, Tadalafil
D02008
DB00820
FT-0080116
GF 196960
GF-196960
 
HMS2051N17
HSDB 7303
IC 351
IC-351
ICOS 351
Ic351
KS-1117
LS-186558
LS-187015
LS-187770
Lilly brand of tadalafil
MLS000759426
MLS001165782
MLS001195644
MLS001424132
MolPort-002-885-864
S1512_Selleck
SAM001246586
SMR000466321
Tadalafil
Tadalafil (JAN/USAN/INN)
Tadalafil [USAN]
Tadanafil
UNII-742SXX0ICT
ZINC03993855
13Phosphodiesterase InhibitorsPhase 3, Phase 21289
14Vasodilator AgentsPhase 3, Phase 23543
15Phosphodiesterase 5 InhibitorsPhase 3589
16
Acetylcysteineapproved, investigationalPhase 2330616-91-112035
Synonyms:
(2R)-2-acetylamino-3-sulfanylpropanoic acid
(R)-2-acetylamino-3-mercaptopropanoic acid
(R)-mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
Fluprowit
 
L-Acetylcysteine
L-acetylcysteine
L-α-acetamido-β-mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetyl-L-(+)-cysteine
N-acetyl-L-cysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
17Pharmaceutical SolutionsPhase 28192
18N-monoacetylcystinePhase 2330
19Respiratory System AgentsPhase 24997
20AnticoagulantsPhase 22623
21Blood SubstitutesPhase 2253
22Plasma SubstitutesPhase 2240
23DextransPhase 2104
24ExpectorantsPhase 2404
25Protective AgentsPhase 27443
26Anti-Arrhythmia AgentsPhase 23093
27Antiviral AgentsPhase 29967
28SimendanPhase 255
29AntidotesPhase 21071
30AntioxidantsPhase 23050
31Anti-Infective AgentsPhase 222062
32HematinicsPhase 1, Phase 21684
33Epoetin alfaPhase 1, Phase 2658113427-24-0
34
Dexmedetomidineapproved, vet_approvedPhase 159276631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
35Neurotransmitter AgentsPhase 118340
36Adrenergic AgentsPhase 15352
37Hypnotics and SedativesPhase 12616
38Central Nervous System DepressantsPhase 113403
39Peripheral Nervous System AgentsPhase 123689
40Adrenergic alpha-2 Receptor AgonistsPhase 1980
41Analgesics, Non-NarcoticPhase 16501
42Adrenergic alpha-AgonistsPhase 11734
43Adrenergic AgonistsPhase 13027
44AnalgesicsPhase 111733
45
Dobutamineapproved11934368-04-236811
Synonyms:
(+-)-4-(2-((3-(P-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
(+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol
3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine
34368-04-2
34368-04-2 (Parent)
4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol
52663-81-7 (hydrochloride)
74753-15-4
74753-15-4 (hydrobromide)
AC1L1WFF
AC1Q7AD1
BPBio1_000489
BRD-A78322124-003-03-3
BSPBio_000443
C06967
CHEBI:4670
CHEMBL926
CID36811
D03879
DB00841
DL-Dobutamine
DL-dobutamine
Dobutamin
Dobutamina
Dobutamina [INN-Spanish]
Dobutamine
Dobutamine (USP/INN)
Dobutamine Hcl
Dobutamine Hcl in Dextrose 5%
 
Dobutamine Hydrochloride
Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer
Dobutamine [USAN:BAN:INN]
Dobutamine [USAN]
Dobutamine [Usan:Ban:Inn]
Dobutamine [Usan]
Dobutamine hydrobromide
Dobutaminum
Dobutaminum [INN-Latin]
Dobutrex
EINECS 277-982-4
HMS2089K05
Inotrex
L001157
LS-174467
LY 81929
Lilly 81929
Lopac0_000365
NCGC00015321-05
NCGC00024629-02
NCGC00024629-03
Prestwick0_000352
Prestwick1_000352
Prestwick2_000352
Prestwick3_000352
Racemic-Dobutamine
Racemic-dobutamine
SPBio_002364
UNII-0WR771DJXV
UNII-3S12J47372
dobutamine
dobutamine(usp)
rac-Dobutamine
rac-dobutamine
racemic-Dobutamine
46Adrenergic Antagonists1573
47Adrenergic beta-Antagonists1193

Interventional clinical trials:

(show all 38)
idNameStatusNCT IDPhase
1Eplerenone in Systemic Right VentricleCompletedNCT00703352Phase 4
2The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseTerminatedNCT01971593Phase 4
3Comparison of Hematocrit Levels in Infant Heart SurgeryCompletedNCT00006183Phase 3
4Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
5COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve DysfunctionRecruitingNCT02744677Phase 3
6Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and FunctionNot yet recruitingNCT03049540Phase 3
7Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 2
8N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)CompletedNCT00374088Phase 2
9Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2
10Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryActive, not recruitingNCT00513240Phase 1, Phase 2
11A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsRecruitingNCT01915277Phase 1
12T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart DiseaseUnknown statusNCT02350829
13MRI Study After Arterial Switch Operation in Patients With Transposition of the Great ArteriesCompletedNCT01916499
14Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular FunctionCompletedNCT00313352
15CT Coronary Angiography After Arterial Switch OperationCompletedNCT01153776
16Physical Training in Transposition of the Great ArteriesCompletedNCT00837603
17Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) FindingsCompletedNCT01430897
18Myocardial Contrast Echocardiography in Congenital Heart DiseaseCompletedNCT00412685
19Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic MethodsCompletedNCT01907971
20Quality of Life in Young Adults With Congenital Heart DiseaseCompletedNCT02463292
21Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental OutcomeCompletedNCT00713635
22Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
23Genes Causing Ebstein's AnomalyCompletedNCT00497705
24A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal DefectCompletedNCT02361008
25Fibrosis, Valvular and Ventricular Function in Patients With TGARecruitingNCT02588989
26Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young AdultsRecruitingNCT02415491
27Genetic Determinants of Congenital Heart Disease OutcomesRecruitingNCT01656941
28Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic ResonanceRecruitingNCT02161471
29Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)RecruitingNCT02184169
30Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults.RecruitingNCT02542345
31Assessing Neurodevelopment in Congenital Heart Disease.RecruitingNCT02996630
32Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility StudyRecruitingNCT03022708
33Surgical Planning for Reconstruction of Complex Heart DefectsRecruitingNCT00972608
34National Congenital Heart Disease AuditRecruitingNCT02303535
35Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract ReconstructionActive, not recruitingNCT02700100
36Late Function After Surgery for Transposition of the Great ArteriesEnrolling by invitationNCT03078413
37The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart DiseaseNot yet recruitingNCT03073122
38Trial Comparing One-stage With Two-stage Basilic Vein TranspositionTerminatedNCT01274117

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Genetic Tests for Transposition of the Great Arteries

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Genetic tests related to Transposition of the Great Arteries:

id Genetic test Affiliating Genes
1 Transposition of Great Arteries27
2 Transposition of the Great Arteries27

Anatomical Context for Transposition of the Great Arteries

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MalaCards organs/tissues related to Transposition of the Great Arteries:

36
Heart, Skin, Lung, Brain, Testes, Liver, Pituitary

Publications for Transposition of the Great Arteries

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Articles related to Transposition of the Great Arteries:

(show top 50)    (show all 791)
idTitleAuthorsYear
1
The use of contrast echo to detect shunts at atrial level in a Mustard or Senning repair for transposition of the great arteries: you can teach an old dog new tricks. (28065912)
2017
2
Transposition of the Great Arteries in the Developing World: Surgery and Outcomes. (28057249)
2017
3
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries. (28064156)
2017
4
Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum. (28077506)
2017
5
Mid-term Outcomes in Patients with Congenitally Corrected Transposition of the Great Arteries: A Single Center Experience. (28088601)
2017
6
Play the Map: Ablation of a Macro Reentrant Atrial Tachycardia in a Patient After Senning Repair for Transposition of the Great Arteries. (28045674)
2017
7
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation. (28057382)
2017
8
Surgical Treatment of Complete Transposition of the Great Arteries in Newborn. (27647199)
2016
9
Mechanisms and predictors of recurrent tachycardia after catheter ablation for d-transposition of the great arteries after the Mustard or Senning operation. (27908766)
2016
10
Longitudinal strain of systemic right ventricle correlates with exercise capacity in adult with transposition of the great arteries after atrial switch. (27179205)
2016
11
Severe Pulmonary Vascular Obstructive Disease After Neonatal Arterial Switch Operation for Simple Transposition of the Great Arteries. (27098605)
2016
12
Aortic Translocation for Repair of Transposition of the Great Arteries (S,D,L) With Ventricular Septal Defect and Pulmonic Stenosis. (26694279)
2016
13
Processing Speed, Executive Function, and Academic Achievement in Children With Dextro-Transposition of the Great Arteries: Testing a Longitudinal Developmental Cascade Model. (27077787)
2016
14
Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography. (27659876)
2016
15
Understanding the mechanism for branch pulmonary artery stenosis after the arterial switch operation for transposition of the great arteries. (27025515)
2016
16
Mapping and ablation of anteroseptal atrial tachycardia in patients with congenitally corrected transposition of the great arteries: implication of pulmonary sinus cusps. (27965318)
2016
17
Percutaneous tricuspid valve repair using MitraClipAr for the treatment of severe tricuspid valve regurgitation in a patient with congenitally corrected transposition of the great arteries. (27412162)
2016
18
Single coronary" in transposition of the great arteries: Why are we still talking about it? (27131848)
2016
19
Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries. (27547505)
2016
20
Echocardiography vs magnetic resonance imaging in assessing ventricular function and systemic atrioventricular valve status in adults with congenitally corrected transposition of the great arteries. (27542349)
2016
21
Acute myocardial infarction with isolated congenitally corrected transposition of the great arteries. (27034557)
2016
22
Children and Adolescents Show Altered Visual Working Memory Related Brain Activity More Than One Decade After Arterial Switch Operation for D-Transposition of the Great Arteries. (27918206)
2016
23
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries). (27401272)
2016
24
Isolated congenitally corrected transposition of the great arteries with dextroversion discovered incidentally in a patient with cocaine-induced acute myocardial infarction. (27034558)
2016
25
HeartWare ventricular assist device as a bridge to heart transplantation in a patient with congenitally corrected transposition of the great arteries and dextrocardia. (27521176)
2016
26
Pulmonary Arterial Hypertension and Neonatal Arterial Switch Surgery for Correction of Transposition of the Great Arteries. (27156642)
2016
27
Survival of Three Neonates With Congenital Diaphragmatic Hernia and d-Transposition of the Great Arteries. (27154795)
2016
28
MelodyAr pulmonary valve implantation in two teenage patients with congenitally corrected transposition of the great arteries status after Senning atrial switch operation. (27748225)
2016
29
Assessment of myocardial function using MRI-based feature tracking in adults after atrial repair of transposition of the great arteries: Reference values and clinical utility. (27389449)
2016
30
D-Transposition of the Great Arteries and ductal dependent pulmonary circulation. (28041645)
2016
31
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction. (27130951)
2016
32
When left turns to right: a congenital corrected transposition of the great arteries with an azygos continuation without another major cardiac abnormality. (27401820)
2016
33
In situ reconstruction using the half-ring-shaped aortic wall for transposition of the great arteries. (27064080)
2016
34
Atrial tachyarrhythmias after atrial switch operation for transposition of the great arteries: Treating old surgery with new catheters. (27018378)
2016
35
Multimodality Imaging Guidelines of Patients with Transposition of the Great Arteries: A Report from the American Society of Echocardiography Developed inA Collaboration with the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. (27372954)
2016
36
Prenatal Echocardiographic Assessment of Foramen Ovale Appearance in Fetuses with D-Transposition of the Great Arteries and Impact on Neonatal Outcome. (27654925)
2016
37
Transposition of the Great Arteries and Common Variants. (27490620)
2016
38
Long-Term Follow-Up of the Conal Flap Method for Tricuspid Malinsertion in Transposition of the Great Arteries With Ventricular Septal Defect and Pulmonary Stenosis. (27083244)
2016
39
Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome. (27892741)
2016
40
Pregnancy in women with complete transposition of the great arteries following the atrial switch procedure. A study from three of the largest Adult Congenital Heart Disease centers in Poland. (27072884)
2016
41
Hemodynamic consequences of a restrictive ductus arteriosus and foramen ovale in fetal transposition of the great arteries. (27589547)
2016
42
Re: Late diagnosis of isolated congenitally corrected transposition of the great arteries in a 92-year old woman. (26834232)
2016
43
Internal Cardioverter Defibrillator Indications and Therapies after Atrial Baffle Procedure for d-Transposition of the Great Arteries: A Multicenter Analysis. (27503213)
2016
44
Transposition of the great arteries: Rationale for tailored preoperative management. (28024917)
2016
45
Double Switch Procedure and Surgical Alternatives for the Treatment of Congenitally Corrected Transposition of the Great Arteries. (26956686)
2016
46
Current mid-term outcome with an integrated surgical strategy for correction of d-transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction. (27009103)
2016
47
Reoperations and catheter interventions in patients with transposition of the great arteries after the arterial switch operation. (27615267)
2016
48
Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation. (27847084)
2016
49
Long-Term Follow-Up of the Half-Turned Truncal Switch Operation for Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis. (27064891)
2016
50
Successful thrombolytic therapy in a patient with congenital corrected transposition of the great arteries. (28000492)
2016

Variations for Transposition of the Great Arteries

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Expression for genes affiliated with Transposition of the Great Arteries

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Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for genes affiliated with Transposition of the Great Arteries

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GO Terms for genes affiliated with Transposition of the Great Arteries

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Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1atrial septum morphogenesisGO:006041310.8GATA4, NKX2-5
2cardiac ventricle morphogenesisGO:000320810.8GATA4, NKX2-5
3pulmonary myocardium developmentGO:000335010.8NKX2-5, PITX2
4endocardial cushion developmentGO:000319710.8CRELD1, GATA4
5response to vitamin AGO:003318910.7GATA4, PITX2
6thyroid gland developmentGO:003087810.7NKX2-5, TBX1
7right ventricular cardiac muscle tissue morphogenesisGO:000322110.7NKX2-5, ZFPM2
8heart loopingGO:000194710.6GATA4, NKX2-5, ZIC3
9atrial cardiac muscle cell developmentGO:005501410.6NKX2-5, NKX2-6
10embryonic heart tube developmentGO:003505010.6NKX2-5, NKX2-6
11lymph vessel developmentGO:000194510.6NR2F2, TBX1
12intestinal epithelial cell differentiationGO:006057510.5GATA4, GATA6
13lung developmentGO:003032410.5PITX2, ZFPM2, ZIC3
14positive regulation of cardiac muscle cell proliferationGO:006004510.4GATA6, ZFPM2
15anterior/posterior pattern specificationGO:000995210.4NR2F2, TBX1, ZIC3
16positive regulation of cardioblast differentiationGO:005189110.3GATA4, GATA6, NKX2-5
17pharyngeal system developmentGO:006003710.3NKX2-5, NKX2-6, TBX1
18male gonad developmentGO:000858410.3GATA4, GATA6, PITX2
19vasculogenesisGO:000157010.1NKX2-5, PITX2, ZFPM2
20cardiac muscle cell differentiationGO:005500710.0GATA4, GATA6, NKX2-5, PITX2
21cardiac muscle tissue developmentGO:00487389.9GATA6, NKX2-5, PITX2, ZFPM2
22ventricular cardiac muscle cell developmentGO:00550159.9NKX2-5, NKX2-6, PITX2
23determination of left/right symmetryGO:00073689.9CFAP53, CFC1, PITX2, TBX1, ZIC3
24blood coagulationGO:00075969.9ANXA5, GATA4, GATA6, ZFPM2
25outflow tract septum morphogenesisGO:00031489.9GATA6, NKX2-5, TBX1, ZFPM2
26in utero embryonic developmentGO:00017019.8GATA6, NR2F2, PITX2, ZFPM2
27heart developmentGO:00075079.7NKX2-5, NKX2-6, PITX2, TBX1, ZFPM2
28ventricular septum morphogenesisGO:00604129.6NKX2-5, PITX2, ZFPM2
29regulation of transcription from RNA polymerase II promoterGO:00063579.2MED13L, MED24, NKX2-5, NR2F2, PITX2, TBX1
30positive regulation of transcription from RNA polymerase II promoterGO:00459449.1GATA4, GATA6, NKX2-5, PITX2, TBX1, ZFPM2
31transcription from RNA polymerase II promoterGO:00063668.8GATA4, GATA6, MED24, NKX2-5, PITX2, ZFPM2
32multicellular organism developmentGO:00072758.7CFAP53, CFC1, NKX1-2, NKX2-5, NKX2-6, PITX2
33positive regulation of transcription, DNA-templatedGO:00458938.1GATA4, GATA6, MED24, NKX2-5, NR2F2, PITX2
34transcription, DNA-templatedGO:00063517.7GATA4, GATA6, MED13L, MED24, NKX2-6, NR2F2
35regulation of transcription, DNA-templatedGO:00063556.9GATA4, GATA6, MED13L, MED24, NKX1-2, NKX2-5

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription cofactor activityGO:000110410.2MED13L, MED24, NKX2-5
2RNA polymerase II transcription factor bindingGO:000108510.1GATA4, GATA6, ZFPM2
3transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.5GATA4, GATA6, NKX2-5
4transcription factor bindingGO:00081349.4GATA4, GATA6, NKX2-5, PITX2, ZFPM2
5DNA bindingGO:00036778.7GATA4, GATA6, NKX2-5, NR2F2, PITX2, TBX1
6transcription factor activity, sequence-specific DNA bindingGO:00037008.5GATA4, GATA6, NKX2-5, NKX2-6, NR2F2, PITX2
7sequence-specific DNA bindingGO:00435658.0GATA4, GATA6, NKX1-2, NKX2-5, NKX2-6, NR2F2

Sources for Transposition of the Great Arteries

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet