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MCID: TRN044
MIFTS: 49

Transposition of the Great Arteries

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Transposition of the Great Arteries

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MalaCards integrated aliases for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 49 28
Transposition of the Great Arteries, Dextro-Looped 1 69
Dextro-Looped Transposition of the Great Arteries 49
Dtga 49

Classifications:

MalaCards categories:
Global: Rare diseases
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External Ids:

UMLS 69 C1837341
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Summaries for Transposition of the Great Arteries

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NIH Rare Diseases : 49 Transposition of the great arteries (TGA) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. The aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. Symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). The exact cause of TGA in most cases is unknown. Surgery is done to correct the abnormality during the first few days of life. Last updated: 6/27/2011

MalaCards based summary : Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to isolated congenitally uncorrected transposition of the great arteries and dextro-looped transposition of the great arteries. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesodermal Commitment Pathway. The drugs Spironolactone and Eplerenone have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Transposition of the Great Arteries

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Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 isolated congenitally uncorrected transposition of the great arteries 34.1 CFC1 ZIC3
2 dextro-looped transposition of the great arteries 33.9 CFC1 GDF1 MED13L NKX2-6 ZIC3
3 heterotaxy, visceral, 1, x-linked 32.4 GDF1 ZIC3
4 conotruncal heart malformations 30.8 CFC1 CRELD1 GATA4 GATA6 GDF1 NKX2-5
5 tricuspid atresia 30.3 CRELD1 GDF1 NKX2-5 NKX2-6 ZFPM2
6 pulmonic stenosis 30.1 NR2F2 ZIC3
7 atrioventricular block 30.1 GATA4 NKX2-5 NPPB
8 total anomalous pulmonary venous return 1 30.0 CRELD1 NKX2-6
9 patent foramen ovale 29.9 GATA4 GATA6 MED13L NKX2-5
10 diaphragmatic hernia, congenital 29.8 GATA4 GATA6 NR2F2 ZFPM2
11 ventricular septal defect 29.8 GATA4 GATA6 GDF1 NKX2-5 NKX2-6 NPPB
12 atrial heart septal defect 29.4 CRELD1 GATA4 GDF1 NKX2-5 NKX2-6
13 atrioventricular septal defect 29.2 CRELD1 GATA4 GATA6 GDF1 NKX2-5 NKX2-6
14 tricuspid valve disease 28.9 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6 NPPB
15 heart disease 28.1 CFC1 CRELD1 GATA4 GDF1 NKX2-5 NKX2-6
16 tetralogy of fallot 28.0 CRELD1 GATA4 GATA6 GDF1 NKX2-5 NKX2-6
17 congenitally corrected transposition of the great arteries 12.8
18 transposition of the great arteries, dextro-looped 1 12.8
19 transposition of the great arteries, dextro-looped 3 12.7
20 congenitally uncorrected transposition of the great arteries with cardiac malformation 12.3
21 congenitally uncorrected transposition of the great arteries with coarctation 12.3
22 double discordia 11.7
23 mental retardation and distinctive facial features with or without cardiac defects 11.3
24 heterotaxy, visceral, 6, autosomal 11.1
25 congenital heart defects, multiple types, 4 11.1
26 dextrocardia 10.5
27 situs inversus 10.4
28 pulmonary hypertension 10.4
29 pulmonary valve insufficiency 10.3 NKX2-6 NPPB
30 aging 10.3
31 esophageal atresia/tracheoesophageal fistula 10.3 NKX2-6 TBX1
32 aortopulmonary window 10.3
33 pulmonary hypertension, primary, 1 10.2
34 aneurysm 10.2
35 toxic myocarditis 10.2 NPPB ZIC3
36 hypoplastic left heart syndrome 1 10.2
37 hypoplastic left heart syndrome 10.2
38 cor triatriatum 10.2
39 subpulmonary stenosis 10.2
40 myocardial infarction 10.1
41 right aortic arch 10.1
42 46,xy partial gonadal dysgenesis 10.1 GATA4 ZFPM2
43 heterotaxy 10.1 CFAP53 CFC1 GDF1 ZIC3
44 brain injury 10.1
45 coronary artery anomaly 10.1
46 aortic coarctation 10.1
47 cardiac conduction defect 10.1
48 criss-cross heart 10.1
49 cerebritis 10.1
50 velocardiofacial syndrome 10.1 CFC1 NKX2-6 TBX1

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to Transposition of the Great Arteries
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Symptoms & Phenotypes for Transposition of the Great Arteries

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MGI Mouse Phenotypes related to Transposition of the Great Arteries:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 PITX2 TBX1 ZFPM2 ZIC3 GATA6 NKX2-6
2 cellular MP:0005384 10.2 ZIC3 PITX2 TBX1 ZFPM2 GATA6 NKX2-6
3 embryo MP:0005380 10.11 TBX1 ZIC3 PITX2 GATA6 NKX2-6 NR2F2
4 mortality/aging MP:0010768 10.03 ZIC3 PITX2 TBX1 ZFPM2 NR2F2 NKX2-5
5 digestive/alimentary MP:0005381 9.95 ZIC3 PITX2 TBX1 NR2F2 GDF1 GATA4
6 craniofacial MP:0005382 9.91 ZIC3 PITX2 TBX1 NKX2-5 GDF1 CRELD1
7 limbs/digits/tail MP:0005371 9.8 ZIC3 PITX2 TBX1 GATA6 ANXA5 GATA4
8 muscle MP:0005369 9.76 PITX2 TBX1 ZFPM2 GATA6 NR2F2 MED24
9 normal MP:0002873 9.65 ZIC3 PITX2 TBX1 ZFPM2 GATA6 NKX2-6
10 respiratory system MP:0005388 9.28 PITX2 TBX1 ZFPM2 ZIC3 GATA6 NKX2-6
Sources

Drugs & Therapeutics for Transposition of the Great Arteries

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Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2
Eplerenone Approved Phase 4 107724-20-9 443872 150310
3
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
4 diuretics Phase 4
5 Mineralocorticoid Receptor Antagonists Phase 4
6 Mineralocorticoids Phase 4
7 Natriuretic Agents Phase 4
8 Hormone Antagonists Phase 4
9 Hormones Phase 4
10 Diuretics, Potassium Sparing Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
13 Vasodilator Agents Phase 3,Phase 2
14 Phosphodiesterase Inhibitors Phase 3,Phase 2
15 Phosphodiesterase 5 Inhibitors Phase 3
16
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
17 Simendan Investigational Phase 2 131741-08-7
18 Respiratory System Agents Phase 2
19 N-monoacetylcystine Phase 2
20 Dextrans Phase 2
21 Anti-Arrhythmia Agents Phase 2
22 Anticoagulants Phase 2
23 Pharmaceutical Solutions Phase 2
24 Antidotes Phase 2
25 Anti-Infective Agents Phase 2
26 Plasma Substitutes Phase 2
27 Expectorants Phase 2
28 Protective Agents Phase 2
29 Antioxidants Phase 2
30 Blood Substitutes Phase 2
31 Antiviral Agents Phase 2
32 Hematinics Phase 1, Phase 2
33 Epoetin alfa Phase 1, Phase 2 113427-24-0
34
Dexmedetomidine Approved, Vet_approved Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
35 Adrenergic Agents Phase 1
36 Neurotransmitter Agents Phase 1
37 Analgesics Phase 1
38 Central Nervous System Depressants Phase 1
39 Adrenergic Agonists Phase 1
40 Adrenergic alpha-2 Receptor Agonists Phase 1
41 Adrenergic alpha-Agonists Phase 1
42 Analgesics, Non-Narcotic Phase 1
43 Peripheral Nervous System Agents Phase 1
44 Hypnotics and Sedatives Phase 1
45
Dobutamine Approved 34368-04-2 36811
46 Adrenergic Antagonists
47 Adrenergic beta-Antagonists

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Eplerenone in Systemic Right Ventricle Completed NCT00703352 Phase 4 Eplerenone
2 The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease Terminated NCT01971593 Phase 4 Eplerenone
3 Comparison of Hematocrit Levels in Infant Heart Surgery Completed NCT00006183 Phase 3
4 Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest Completed NCT00000470 Phase 3
5 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function Recruiting NCT03049540 Phase 3 Tadalafil 20 MG;Placebo 20 MG
6 Levosimendan Administration in Neonates With Transposition of the Great Arteries Completed NCT01120106 Phase 2 levosimendan;placebo
7 N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Completed NCT00374088 Phase 2 N-acetylcysteine;Placebo
8 Hypertonic Saline Dextran in Pediatric Cardiac Surgery Completed NCT00199771 Phase 2 7.5% NaCl in 6% dextran 70 solution
9 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting NCT00513240 Phase 1, Phase 2 Erythropoetin;Normal saline
10 A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics Recruiting NCT01915277 Phase 1 Dexmedetomidine
11 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Unknown status NCT02415491
12 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
13 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
14 Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular Function Completed NCT00313352
15 Physical Training in Transposition of the Great Arteries Completed NCT00837603
16 CT Coronary Angiography After Arterial Switch Operation Completed NCT01153776
17 Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings Completed NCT01430897
18 Myocardial Contrast Echocardiography in Congenital Heart Disease Completed NCT00412685
19 Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic Methods Completed NCT01907971
20 Quality of Life in Young Adults With Congenital Heart Disease Completed NCT02463292
21 Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental Outcome Completed NCT00713635
22 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
23 Genes Causing Ebstein's Anomaly Completed NCT00497705
24 A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect Completed NCT02361008
25 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
26 Genetic Determinants of Congenital Heart Disease Outcomes Recruiting NCT01656941
27 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
28 The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease Recruiting NCT03073122
29 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Recruiting NCT02184169
30 Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults. Recruiting NCT02542345
31 Assessing Neurodevelopment in Congenital Heart Disease. Recruiting NCT02996630
32 Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility Study Recruiting NCT03022708
33 COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction Recruiting NCT02744677
34 Surgical Planning for Reconstruction of Complex Heart Defects Recruiting NCT00972608
35 Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract Reconstruction Active, not recruiting NCT02700100
36 Late Function After Surgery for Transposition of the Great Arteries Enrolling by invitation NCT03078413

Search NIH Clinical Center for Transposition of the Great Arteries

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Genetic Tests for Transposition of the Great Arteries

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Genetic tests related to Transposition of the Great Arteries:

# Genetic test Affiliating Genes
1 Transposition of the Great Arteries 28
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Anatomical Context for Transposition of the Great Arteries

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MalaCards organs/tissues related to Transposition of the Great Arteries:

38
Heart, Skin, Lung, Brain, Testes, Liver, Pituitary
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Publications for Transposition of the Great Arteries

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Articles related to Transposition of the Great Arteries:

(show top 50) (show all 843)
# Title Authors Year
1
Catheter ablation of manifest posteroseptal accessory pathway associated with coronary sinus diverticula in a child with congenitally corrected transposition of the great arteries. ( 29424737 )
2018
2
Contemporary management and outcomes in congenitally corrected transposition of the great arteries. ( 29326110 )
2018
3
Aortopulmonary collaterals in neonates with d-transposition of the great arteries - Clinical significance early after arterial switch operation. ( 29444748 )
2018
4
Airway ciliary dysfunction and respiratory symptoms in patients with transposition of the great arteries. ( 29444099 )
2018
5
Cerebral oximetry monitoring in the management of severe hypoxaemia associated with transposition of the great arteries with balloon atrial septostomy. ( 29366495 )
2018
6
An Analysis of Left Ventricular Retraining in Patients With Dextro- and Levo-Transposition of the Great Arteries. ( 29274314 )
2018
7
Role of myocardial collagen degradation and fibrosis in right ventricle dysfunction in transposition of the great arteries after atrial switch. ( 29433967 )
2018
8
Coronary sinus ostial atresia with persistent left superior caval vein in a patient with congenitally corrected transposition of the great arteries. ( 29233231 )
2018
9
Analysis of DICER1 in familial and sporadic cases of transposition of the great arteries. ( 29399970 )
2018
10
Primary Arterial Switch Operation for Late Referral of Transposition of the Great Arteries with Intact Ventricular Septum in the Current Era: Do We Still Need a Rapid Two-Stage Operation? ( 29310554 )
2018
11
Suitability of cardiac resynchronisation therapy in patients with Fontan circulation and congenitally corrected transposition of the great arteries. ( 28886927 )
2017
12
Promising Outcome of Anatomic Correction of Corrected Transposition of the Great Arteries. ( 28648534 )
2017
13
Comparison of systemic right ventricular function in transposition of the great arteries after atrial switch and congenitally corrected transposition of the great arteries. ( 28668979 )
2017
14
Successful coronary transfer for transposition of the great arteries with bilateral intramural coronary arteries from a single aortic sinus. ( 29119449 )
2017
15
Transposition of the great arteries - a phenotype associated with 16p11.2 duplications? ( 29317992 )
2017
16
Echocardiography-Derived Left Ventricular Outflow Tract Gradient and Left Ventricular Posterior Wall Thickening Are Associated with Outcomes for Anatomic Repair in Congenitally Corrected Transposition of the Great Arteries. ( 28579248 )
2017
17
Aortic sinus pouch technique for transposition of the great arteries with intramural coronary artery. ( 29198791 )
2017
18
Relationship between interatrial communication, ductus arteriosus, and pulmonary flow patterns in fetuses with transposition of the great arteries: prediction of neonatal desaturation. ( 28376948 )
2017
19
Septic coronary embolization in a patient with congenitally corrected transposition of the great arteries. ( 28542031 )
2017
20
Down syndrome and transposition of the great arteries. ( 28857728 )
2017
21
Combined spinal-epidural anesthesia for cesarean section in a parturient with congenitally corrected transposition of the great arteries. ( 29109653 )
2017
22
Detection of Pulmonary Venous Channel Stenosis in a Newly Created Left Atrium After the Senning Procedure in a Child Undergoing a Double Switch Operation for L-Transposition of the Great Arteries. ( 28927693 )
2017
23
Long-term results of anatomic correction for congenitally corrected transposition of the great arteries: A 19-year experience. ( 28476422 )
2017
24
Anatomic Repair of Congenitally Corrected Transposition of the Great Arteries: Single-Center Intermediate-Term Experience. ( 28918529 )
2017
25
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation. ( 28057382 )
2017
26
Mid-term Outcomes in Patients with Congenitally Corrected Transposition of the Great Arteries: A Single Center Experience. ( 28088601 )
2017
27
Coronary Artery Anomalies in Patients With Transposition of the Great Arteries and Their Impact on Postoperative Outcomes. ( 28648541 )
2017
28
Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance. ( 29269355 )
2017
29
Play the Map: Ablation of a Macro Reentrant Atrial Tachycardia in a Patient After Senning Repair for Transposition of the Great Arteries. ( 28045674 )
2017
30
A great imitator in adult cardiology practice: congenitally corrected transposition of the great arteries. ( 28225206 )
2017
31
Transposition of the Great Arteries in the Developing World: Surgery and Outcomes. ( 28057249 )
2017
32
Longitudinal sequential biventricular assessment in adults with transposition of the great arteries and relationship with adverse outcomes. ( 28818352 )
2017
33
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. ( 28825385 )
2017
34
Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study. ( 28508510 )
2017
35
Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries. ( 28281729 )
2017
36
Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries. ( 28767656 )
2017
37
Assessment of transposition of the great arteries associated with multiple malformations using dual-source computed tomography. ( 29155835 )
2017
38
The use of contrast echo to detect shunts at atrial level in a Mustard or Senning repair for transposition of the great arteries: you can teach an old dog new tricks. ( 28065912 )
2017
39
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries. ( 28064156 )
2017
40
High sensitivity cardiac troponin T and systemic right ventricular function in adults with congenitally corrected transposition of the great arteries. ( 28302319 )
2017
41
Permanent nonselective His bundle pacing in an adult with L-transposition of the great arteries and complete AV block. ( 28543795 )
2017
42
Anatomic Repair Including Hemi-Mustard in Congenitally Corrected Transposition of the Great Arteries: What We know and Still Need to Know. ( 28382070 )
2017
43
Left Ventricular Retraining and Double Switch in Patients With Congenitally Corrected Transposition of the Great Arteries. ( 28329464 )
2017
44
Cognitive outcomes and health-related quality of life in adults two decades after the arterial switch operation for transposition of the great arteries. ( 28476420 )
2017
45
Perinatal and early postnatal outcomes for fetuses with prenatally diagnosed d-transposition of the great arteries: a prospective cohort study assessing the effect of standardised prenatal consultation. ( 28784195 )
2017
46
What surgical improvements are needed to prove that anatomic repair is superior to physiologic repair in the majority of patients with corrected transposition of the great arteries? ( 28666660 )
2017
47
Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum. ( 28077506 )
2017
48
Bloodless Repair for a 3.6 Kilogram Transposition of the Great Arteries with Jehovah's Witness Faith. ( 29302123 )
2017
49
The hemi-Mustard, bidirectional Glenn and Rastelli procedures for anatomical repair of congenitally corrected transposition of the great arteries/left ventricular outflow tract obstruction with positional heart anomaliesa8 . ( 28329265 )
2017
50
Double trouble or singular success: What can we expect from anatomic correction of congenitally corrected transposition of the great arteries? ( 28416336 )
2017
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Variations for Transposition of the Great Arteries

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Expression for Transposition of the Great Arteries

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Search GEO for disease gene expression data for Transposition of the Great Arteries.
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Pathways for Transposition of the Great Arteries

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Pathways related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Human Embryonic Stem Cell Pluripotency 60
Show member pathways
 12.07 CFC1 GATA4 NKX2-5 NPPB
2
Mesodermal Commitment Pathway 1
Show member pathways
 12.04 GATA4 GATA6 PITX2 TBX1 ZIC3
3
Thyroid hormone signaling pathway 36
11.61 GATA4 MED13L MED24
4
Transcriptional Regulatory Network in Embryonic Stem Cell 60
11.2 GATA4 GATA6 ZIC3
5
Heart Development 1
10.68 GATA4 GATA6 NKX2-5 PITX2 TBX1
6
Cardiomyocyte Differentiation through BMP Receptors 60
10.47 GATA4 NKX2-5 NPPB
7
HOP Signaling 60
10.03 GATA4 NKX2-5
Sources

GO Terms for Transposition of the Great Arteries

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Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.91 GATA6 NR2F2 PITX2 ZFPM2
2 blood coagulation GO:0007596 9.91 ANXA5 GATA4 GATA6 ZFPM2
3 heart development GO:0007507 9.89 NKX2-5 NKX2-6 PITX2 TBX1 ZFPM2
4 male gonad development GO:0008584 9.83 GATA4 GATA6 PITX2
5 anterior/posterior pattern specification GO:0009952 9.82 NR2F2 TBX1 ZIC3
6 lung development GO:0030324 9.82 PITX2 ZFPM2 ZIC3
7 heart looping GO:0001947 9.77 GATA4 NKX2-5 ZIC3
8 vasculogenesis GO:0001570 9.77 NKX2-5 PITX2 ZFPM2
9 ventricular septum morphogenesis GO:0060412 9.71 NKX2-5 PITX2 ZFPM2
10 cardiac muscle cell differentiation GO:0055007 9.67 GATA4 GATA6 NKX2-5 PITX2
11 thyroid gland development GO:0030878 9.66 NKX2-5 TBX1
12 embryonic heart tube development GO:0035050 9.66 NKX2-5 NKX2-6
13 response to vitamin A GO:0033189 9.65 GATA4 PITX2
14 pharyngeal system development GO:0060037 9.65 NKX2-5 NKX2-6 TBX1
15 atrial septum morphogenesis GO:0060413 9.64 GATA4 NKX2-5
16 lymph vessel development GO:0001945 9.63 NR2F2 TBX1
17 endocardial cushion development GO:0003197 9.63 CRELD1 GATA4
18 cardiac ventricle morphogenesis GO:0003208 9.62 GATA4 NKX2-5
19 intestinal epithelial cell differentiation GO:0060575 9.58 GATA4 GATA6
20 ventricular cardiac muscle cell development GO:0055015 9.58 NKX2-5 NKX2-6 PITX2
21 pulmonary myocardium development GO:0003350 9.56 NKX2-5 PITX2
22 outflow tract septum morphogenesis GO:0003148 9.56 GATA6 NKX2-5 TBX1 ZFPM2
23 atrial cardiac muscle cell development GO:0055014 9.55 NKX2-5 NKX2-6
24 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.51 NKX2-5 ZFPM2
25 positive regulation of cardioblast differentiation GO:0051891 9.5 GATA4 GATA6 NKX2-5
26 cardiac muscle tissue development GO:0048738 9.46 GATA6 NKX2-5 PITX2 ZFPM2
27 determination of left/right symmetry GO:0007368 9.35 CFAP53 CFC1 PITX2 TBX1 ZIC3
28 positive regulation of transcription, DNA-templated GO:0045893 9.28 GATA4 GATA6 MED24 NKX2-5 NR2F2 PITX2
29 transcription, DNA-templated GO:0006351 10.28 GATA4 GATA6 MED13L MED24 NKX2-6 NR2F2
30 regulation of transcription, DNA-templated GO:0006355 10.21 GATA4 GATA6 MED13L MED24 NKX1-2 NKX2-5
31 multicellular organism development GO:0007275 10.13 CFAP53 CFC1 NKX1-2 NKX2-5 NKX2-6 PITX2
32 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 GATA4 GATA6 NKX2-5 PITX2 TBX1 ZFPM2
33 regulation of transcription by RNA polymerase II GO:0006357 10.04 MED13L MED24 NKX2-5 NR2F2 PITX2 TBX1
34 transcription by RNA polymerase II GO:0006366 10 GATA4 GATA6 MED24 NKX2-5 PITX2 ZFPM2

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 GATA4 GATA6 NKX2-5 NR2F2 PITX2 TBX1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.71 GATA6 NKX2-5 PITX2 ZIC3
3 transcription factor binding GO:0008134 9.65 GATA4 GATA6 NKX2-5 PITX2 ZFPM2
4 DNA binding transcription factor activity GO:0003700 9.56 GATA4 GATA6 NKX2-5 NKX2-6 NR2F2 PITX2
5 RNA polymerase II transcription factor binding GO:0001085 9.5 GATA4 GATA6 ZFPM2
6 RNA polymerase II transcription cofactor activity GO:0001104 9.33 MED13L MED24 NKX2-5
7 sequence-specific DNA binding GO:0043565 9.28 GATA4 GATA6 NKX1-2 NKX2-5 NKX2-6 NR2F2
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Sources for Transposition of the Great Arteries

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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