MCID: TRN044
MIFTS: 46

Transposition of the Great Arteries

Categories: Rare diseases

Aliases & Classifications for Transposition of the Great Arteries

MalaCards integrated aliases for Transposition of the Great Arteries:

Name: Transposition of the Great Arteries 50 29
Transposition of the Great Arteries, Dextro-Looped 1 69
Dextro-Looped Transposition of the Great Arteries 50
Dtga 50
Tga 50

Classifications:



Summaries for Transposition of the Great Arteries

NIH Rare Diseases : 50 transposition of the great arteries (tga) is a type of congenital heart defect in which there is a reversal of the normal connections of the aorta and the pulmonary artery with the heart. the aorta and pulmonary artery are reversed, which causes oxygen-poor blood to be circulated to the body and oxygen-rich blood to be circulated between the lungs and the heart, rather than to the body. symptoms are apparent at birth and include great difficulty breathing and severe cyanosis (a bluish discoloration of the skin). the exact cause of tga in most cases is unknown. surgery is done to correct the abnormality during the first few days of life. last updated: 6/27/2011

MalaCards based summary : Transposition of the Great Arteries, also known as transposition of the great arteries, dextro-looped 1, is related to intestinal atresia and congenitally corrected transposition of the great arteries. An important gene associated with Transposition of the Great Arteries is MED13L (Mediator Complex Subunit 13 Like), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesodermal Commitment Pathway. The drugs Eplerenone and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are cardiovascular system and cellular

Related Diseases for Transposition of the Great Arteries

Diseases related to Transposition of the Great Arteries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 intestinal atresia 29.7 GATA4 NR2F2 ZFPM2
2 congenitally corrected transposition of the great arteries 12.7
3 transposition of the great arteries, dextro-looped 1 12.6
4 dextro-looped transposition of the great arteries 12.3
5 isolated congenitally uncorrected transposition of the great arteries 12.2
6 congenitally uncorrected transposition of the great arteries with cardiac malformation 12.2
7 congenitally uncorrected transposition of the great arteries with coarctation 12.2
8 transposition of great arteries, dextro-looped 3 12.0
9 transient global amnesia 11.8
10 conotruncal heart malformations 11.8
11 mental retardation and distinctive facial features with or without cardiac defects 11.2
12 congenital heart defects, multiple types, 4 11.0
13 heterotaxy, visceral, 6, autosomal recessive 11.0
14 heterotaxy, visceral, 1, x-linked 11.0
15 chromosome xq26.3 duplication syndrome 10.9 GDF1 ZIC3
16 ventricular septal defect 10.7
17 left ventricular outflow tract obstruction 10.5
18 dextrocardia 10.4
19 situs inversus 10.4
20 cloacal exstrophy 10.4 NKX2-6 TBX1
21 ascending cholangitis 10.4 GDF1 NKX2-6 NPPB
22 pulmonary hypertension 10.3
23 radioulnar synostosis 10.3 NR2F2 ZIC3
24 ophthalmia neonatorum 10.3 NPPB ZIC3
25 tricuspid atresia 10.3
26 fleck retina of kandori 10.3 CRELD1 NKX2-6
27 ichthyosis lamellar 2 10.3 NKX2-5 NKX2-6 NPPB
28 pleomorphic liposarcoma 10.3 NKX2-6 NPPB
29 aortopulmonary window 10.2
30 tetralogy of fallot 10.2
31 heart disease 10.2
32 aneurysm 10.2
33 hing torack dowston syndrome 10.2 CFAP53 CFC1 GDF1 ZIC3
34 idiopathic recurrent pericarditis 10.1 GATA4 ZFPM2
35 testicular germ cell tumor non-seminomatous 10.1 CRELD1 NPPB ZIC3
36 cor triatriatum 10.1
37 subpulmonary stenosis 10.1
38 myocardial infarction 10.1
39 hypoplastic left heart syndrome 10.1
40 atrioventricular block 10.1
41 right aortic arch 10.1
42 complete atrioventricular canal-left heart obstruction syndrome 10.0 CRELD1 GATA4
43 persistent eustachian valve 10.0 CRELD1 GATA4
44 brain injury 10.0
45 atrioventricular septal defect 10.0
46 patent foramen ovale 10.0
47 congenital diaphragmatic hernia 10.0
48 aortic coarctation 10.0
49 sudden cardiac death 10.0
50 criss-cross heart 10.0

Graphical network of the top 20 diseases related to Transposition of the Great Arteries:



Diseases related to Transposition of the Great Arteries

Symptoms & Phenotypes for Transposition of the Great Arteries

MGI Mouse Phenotypes related to Transposition of the Great Arteries:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 ZFPM2 ZIC3 GDF1 MED24 TBX1 NKX2-5
2 cellular MP:0005384 10.1 TBX1 ZFPM2 ZIC3 PITX2 GDF1 MED24
3 embryo MP:0005380 10.02 ZIC3 TBX1 MED24 NKX2-5 GATA4 NKX2-6
4 digestive/alimentary MP:0005381 9.91 TBX1 ZIC3 PITX2 GDF1 NKX2-5 GATA4
5 muscle MP:0005369 9.76 ZFPM2 MED24 TBX1 NKX2-5 GATA4 NR2F2
6 limbs/digits/tail MP:0005371 9.73 TBX1 ZIC3 PITX2 ANXA5 GATA4 GATA6
7 normal MP:0002873 9.65 ZFPM2 ZIC3 GDF1 TBX1 ANXA5 NKX2-5
8 respiratory system MP:0005388 9.28 ZFPM2 ZIC3 TBX1 NKX2-5 GATA4 NKX2-6

Drugs & Therapeutics for Transposition of the Great Arteries

Drugs for Transposition of the Great Arteries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Mechlorethamine Approved Phase 4 51-75-2 4033
3
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
4 diuretics Phase 4
5 Diuretics, Potassium Sparing Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Mineralocorticoid Receptor Antagonists Phase 4
10 Mineralocorticoids Phase 4
11 Natriuretic Agents Phase 4
12
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
13 Phosphodiesterase Inhibitors Phase 3,Phase 2
14 Vasodilator Agents Phase 3,Phase 2
15 Phosphodiesterase 5 Inhibitors Phase 3
16
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
17 Simendan Investigational Phase 2 131741-08-7
18 Anti-Arrhythmia Agents Phase 2
19 Protective Agents Phase 2
20 Antidotes Phase 2
21 Anti-Infective Agents Phase 2
22 Antioxidants Phase 2
23 Antiviral Agents Phase 2
24 Expectorants Phase 2
25 N-monoacetylcystine Phase 2
26 Pharmaceutical Solutions Phase 2
27 Respiratory System Agents Phase 2
28 Anticoagulants Phase 2
29 Blood Substitutes Phase 2
30 Dextrans Phase 2
31 Plasma Substitutes Phase 2
32 Epoetin alfa Phase 1, Phase 2 113427-24-0
33 Hematinics Phase 1, Phase 2
34
Dexmedetomidine Approved, Vet_approved Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
35 Adrenergic Agents Phase 1
36 Neurotransmitter Agents Phase 1
37 Adrenergic Agonists Phase 1
38 Adrenergic alpha-2 Receptor Agonists Phase 1
39 Adrenergic alpha-Agonists Phase 1
40 Analgesics Phase 1
41 Analgesics, Non-Narcotic Phase 1
42 Central Nervous System Depressants Phase 1
43 Hypnotics and Sedatives Phase 1
44 Peripheral Nervous System Agents Phase 1
45
Dobutamine Approved 34368-04-2 36811
46 Adrenergic Antagonists
47 Adrenergic beta-Antagonists

Interventional clinical trials:

(show all 36)

id Name Status NCT ID Phase Drugs
1 Eplerenone in Systemic Right Ventricle Completed NCT00703352 Phase 4 Eplerenone
2 The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease Terminated NCT01971593 Phase 4 Eplerenone
3 Comparison of Hematocrit Levels in Infant Heart Surgery Completed NCT00006183 Phase 3
4 Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest Completed NCT00000470 Phase 3
5 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function Not yet recruiting NCT03049540 Phase 3 Tadalafil 20 MG;Placebo 20 MG
6 Levosimendan Administration in Neonates With Transposition of the Great Arteries Completed NCT01120106 Phase 2 levosimendan;placebo
7 N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Completed NCT00374088 Phase 2 N-acetylcysteine;Placebo
8 Hypertonic Saline Dextran in Pediatric Cardiac Surgery Completed NCT00199771 Phase 2 7.5% NaCl in 6% dextran 70 solution
9 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting NCT00513240 Phase 1, Phase 2 Erythropoetin;Normal saline
10 A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics Recruiting NCT01915277 Phase 1 Dexmedetomidine
11 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
12 MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Completed NCT01916499
13 Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular Function Completed NCT00313352
14 CT Coronary Angiography After Arterial Switch Operation Completed NCT01153776
15 Physical Training in Transposition of the Great Arteries Completed NCT00837603
16 Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings Completed NCT01430897
17 Myocardial Contrast Echocardiography in Congenital Heart Disease Completed NCT00412685
18 Assessment of Left and Right Ventricular Function in Patients With Ebstein Anomaly With Different Echocardiographic Methods Completed NCT01907971
19 Quality of Life in Young Adults With Congenital Heart Disease Completed NCT02463292
20 Prenatal Effects of Congenital Heart Disease (CHD) on Neurodevelopmental Outcome Completed NCT00713635
21 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
22 Genes Causing Ebstein's Anomaly Completed NCT00497705
23 A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect Completed NCT02361008
24 Fibrosis, Valvular and Ventricular Function in Patients With TGA Recruiting NCT02588989
25 Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Recruiting NCT02415491
26 Genetic Determinants of Congenital Heart Disease Outcomes Recruiting NCT01656941
27 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
28 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study) Recruiting NCT02184169
29 Comparative Assessment of Coronary MR Angiography Vs Coronary Multislice CT After Coronary Artery Reimplantation in Children and Young Adults. Recruiting NCT02542345
30 Assessing Neurodevelopment in Congenital Heart Disease. Recruiting NCT02996630
31 Xeltis Bioabsorbable Pulmonary Valved Conduit Early Feasibility Study Recruiting NCT03022708
32 COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction Recruiting NCT02744677
33 Surgical Planning for Reconstruction of Complex Heart Defects Recruiting NCT00972608
34 Study to Assess Safety of the Pulmonary Valved Conduit (PV-001) in Subjects Undergoing Right Ventricular Outflow Tract Reconstruction Active, not recruiting NCT02700100
35 Late Function After Surgery for Transposition of the Great Arteries Enrolling by invitation NCT03078413
36 The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease Not yet recruiting NCT03073122

Search NIH Clinical Center for Transposition of the Great Arteries

Genetic Tests for Transposition of the Great Arteries

Genetic tests related to Transposition of the Great Arteries:

id Genetic test Affiliating Genes
1 Transposition of the Great Arteries 29

Anatomical Context for Transposition of the Great Arteries

MalaCards organs/tissues related to Transposition of the Great Arteries:

39
Heart, Skin, Lung, Brain, Testes, Liver, Pituitary

Publications for Transposition of the Great Arteries

Articles related to Transposition of the Great Arteries:

(show top 50) (show all 823)
id Title Authors Year
1
Detection of Pulmonary Venous Channel Stenosis in a Newly Created Left Atrium After the Senning Procedure in a Child Undergoing a Double Switch Operation for L-Transposition of the Great Arteries. ( 28927693 )
2017
2
Anatomic Repair of Congenitally Corrected Transposition of the Great Arteries: Single-Center Intermediate-Term Experience. ( 28918529 )
2017
3
Double trouble or singular success: What can we expect from anatomic correction of congenitally corrected transposition of the great arteries? ( 28416336 )
2017
4
Anatomic Repair Including Hemi-Mustard in Congenitally Corrected Transposition of the Great Arteries: What We know and Still Need to Know. ( 28382070 )
2017
5
Permanent nonselective His bundle pacing in an adult with L-transposition of the great arteries and complete AV block. ( 28543795 )
2017
6
Collagen turnover biomarkers and systemic right ventricle remodeling in adults with previous atrial switch procedure for transposition of the great arteries. ( 28767656 )
2017
7
Clinical guidelines for the management of patients with transposition of the great arteries with intact ventricular septum. ( 28077506 )
2017
8
Long-term results of anatomic correction for congenitally corrected transposition of the great arteries: A 19-year experience. ( 28476422 )
2017
9
Relationship between interatrial communication, ductus arteriosus, and pulmonary flow patterns in fetuses with transposition of the great arteries: prediction of neonatal desaturation. ( 28376948 )
2017
10
Transposition of the Great Arteries in the Developing World: Surgery and Outcomes. ( 28057249 )
2017
11
Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study. ( 28508510 )
2017
12
High prevalence of baffle leaks in adults after atrial switch operations for transposition of the great arteries. ( 28064156 )
2017
13
Promising Outcome of Anatomic Correction of Corrected Transposition of the Great Arteries. ( 28648534 )
2017
14
Longitudinal sequential biventricular assessment in adults with transposition of the great arteries and relationship with adverse outcomes. ( 28818352 )
2017
15
High sensitivity cardiac troponin T and systemic right ventricular function in adults with congenitally corrected transposition of the great arteries. ( 28302319 )
2017
16
A great imitator in adult cardiology practice: congenitally corrected transposition of the great arteries. ( 28225206 )
2017
17
Left Ventricular Retraining and Double Switch in Patients With Congenitally Corrected Transposition of the Great Arteries. ( 28329464 )
2017
18
Echocardiography-Derived Left Ventricular Outflow Tract Gradient and Left Ventricular Posterior Wall Thickening Are Associated with Outcomes for Anatomic Repair in Congenitally Corrected Transposition of the Great Arteries. ( 28579248 )
2017
19
Septic coronary embolization in a patient with congenitally corrected transposition of the great arteries. ( 28542031 )
2017
20
Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries. ( 28281729 )
2017
21
Transthoracic echocardiography study of congenitally corrected transposition of the great arteries. ( 28182287 )
2017
22
Response to d-transposition of the great arteries and ductal dependent pulmonary circulation. ( 28057382 )
2017
23
The hemi-Mustard, bidirectional Glenn and Rastelli procedures for anatomical repair of congenitally corrected transposition of the great arteries/left ventricular outflow tract obstruction with positional heart anomaliesa8 . ( 28329265 )
2017
24
Comparison of systemic right ventricular function in transposition of the great arteries after atrial switch and congenitally corrected transposition of the great arteries. ( 28668979 )
2017
25
Coronary Artery Anomalies in Patients With Transposition of the Great Arteries and Their Impact on Postoperative Outcomes. ( 28648541 )
2017
26
Clinical Outcomes after Anatomic Repair Including Hemi-Mustard Operation in Patients with Congenitally Corrected Transposition of the Great Arteries. ( 28382075 )
2017
27
Suitability of cardiac resynchronisation therapy in patients with Fontan circulation and congenitally corrected transposition of the great arteries. ( 28886927 )
2017
28
Play the Map: Ablation of a Macro Reentrant Atrial Tachycardia in a Patient After Senning Repair for Transposition of the Great Arteries. ( 28045674 )
2017
29
Perinatal and early postnatal outcomes for fetuses with prenatally diagnosed d-transposition of the great arteries: a prospective cohort study assessing the effect of standardised prenatal consultation. ( 28784195 )
2017
30
Imaging the adult with transposition of the great arteries. ( 28537999 )
2017
31
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. ( 28825385 )
2017
32
What do we really know about the management of patients with congenitally corrected transposition of the great arteries? ( 28320510 )
2017
33
Down syndrome and transposition of the great arteries. ( 28857728 )
2017
34
Cognitive outcomes and health-related quality of life in adults two decades after the arterial switch operation for transposition of the great arteries. ( 28476420 )
2017
35
The use of contrast echo to detect shunts at atrial level in a Mustard or Senning repair for transposition of the great arteries: you can teach an old dog new tricks. ( 28065912 )
2017
36
Mid-term Outcomes in Patients with Congenitally Corrected Transposition of the Great Arteries: A Single Center Experience. ( 28088601 )
2017
37
What surgical improvements are needed to prove that anatomic repair is superior to physiologic repair in the majority of patients with corrected transposition of the great arteries? ( 28666660 )
2017
38
Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries. ( 27547505 )
2016
39
Re: Late diagnosis of isolated congenitally corrected transposition of the great arteries in a 92-year old woman. ( 26834232 )
2016
40
Left Ventricular Function after Arterial Switch Operation as Assessed by Two-Dimensional Speckle-Tracking Echocardiography in Patients with Simple Transposition of the Great Arteries. ( 27956909 )
2016
41
"Single coronary" in transposition of the great arteries: Why are we still talking about it? ( 27131848 )
2016
42
Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography. ( 27659876 )
2016
43
Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome. ( 27892741 )
2016
44
Longitudinal strain of systemic right ventricle correlates with exercise capacity in adult with transposition of the great arteries after atrial switch. ( 27179205 )
2016
45
L-Transposition of the Great Arteries. ( 27490621 )
2016
46
Hybrid stenting for left ventricular outflow tract obstruction in congenitally corrected transposition of the great arteries. ( 27938457 )
2016
47
Double Switch Procedure and Surgical Alternatives for the Treatment of Congenitally Corrected Transposition of the Great Arteries. ( 26956686 )
2016
48
Long-Term Follow-Up of the Half-Turned Truncal Switch Operation for Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis. ( 27064891 )
2016
49
Atrial tachyarrhythmias after atrial switch operation for transposition of the great arteries: Treating old surgery with new catheters. ( 27018378 )
2016
50
Reoperation for right ventricular outflow tract obstruction after arterial switch operation for transposition of the great arteries and aortic arch obstruction. ( 27130951 )
2016

Variations for Transposition of the Great Arteries

Expression for Transposition of the Great Arteries

Search GEO for disease gene expression data for Transposition of the Great Arteries.

Pathways for Transposition of the Great Arteries

GO Terms for Transposition of the Great Arteries

Cellular components related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.4 GATA4 GATA6 MED13L MED24 NKX1-2 NKX2-5

Biological processes related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.91 GATA6 NR2F2 PITX2 ZFPM2
2 blood coagulation GO:0007596 9.91 ANXA5 GATA4 GATA6 ZFPM2
3 male gonad development GO:0008584 9.83 GATA4 GATA6 PITX2
4 anterior/posterior pattern specification GO:0009952 9.82 NR2F2 TBX1 ZIC3
5 lung development GO:0030324 9.82 PITX2 ZFPM2 ZIC3
6 heart development GO:0007507 9.8 NKX2-5 NKX2-6 PITX2 TBX1 ZFPM2
7 heart looping GO:0001947 9.77 GATA4 NKX2-5 ZIC3
8 vasculogenesis GO:0001570 9.76 NKX2-5 PITX2 ZFPM2
9 ventricular septum morphogenesis GO:0060412 9.7 NKX2-5 PITX2 ZFPM2
10 thyroid gland development GO:0030878 9.67 NKX2-5 TBX1
11 cardiac muscle cell differentiation GO:0055007 9.67 GATA4 GATA6 NKX2-5 PITX2
12 response to vitamin A GO:0033189 9.66 GATA4 PITX2
13 embryonic heart tube development GO:0035050 9.66 NKX2-5 NKX2-6
14 pharyngeal system development GO:0060037 9.65 NKX2-5 NKX2-6 TBX1
15 atrial septum morphogenesis GO:0060413 9.64 GATA4 NKX2-5
16 endocardial cushion development GO:0003197 9.63 CRELD1 GATA4
17 lymph vessel development GO:0001945 9.62 NR2F2 TBX1
18 cardiac ventricle morphogenesis GO:0003208 9.62 GATA4 NKX2-5
19 ventricular cardiac muscle cell development GO:0055015 9.61 NKX2-5 NKX2-6 PITX2
20 intestinal epithelial cell differentiation GO:0060575 9.6 GATA4 GATA6
21 outflow tract septum morphogenesis GO:0003148 9.56 GATA6 NKX2-5 TBX1 ZFPM2
22 pulmonary myocardium development GO:0003350 9.55 NKX2-5 PITX2
23 atrial cardiac muscle cell development GO:0055014 9.54 NKX2-5 NKX2-6
24 positive regulation of cardioblast differentiation GO:0051891 9.5 GATA4 GATA6 NKX2-5
25 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.49 NKX2-5 ZFPM2
26 cardiac muscle tissue development GO:0048738 9.46 GATA6 NKX2-5 PITX2 ZFPM2
27 cell growth involved in cardiac muscle cell development GO:0061049 9.35 GATA4
28 determination of left/right symmetry GO:0007368 9.35 CFAP53 CFC1 PITX2 TBX1 ZIC3
29 positive regulation of transcription, DNA-templated GO:0045893 9.28 GATA4 GATA6 MED24 NKX2-5 NR2F2 PITX2
30 transcription, DNA-templated GO:0006351 10.29 GATA4 GATA6 MED13L MED24 NKX2-6 NR2F2
31 regulation of transcription, DNA-templated GO:0006355 10.23 GATA4 GATA6 MED13L MED24 NKX1-2 NKX2-5
32 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.12 GATA4 GATA6 NKX2-5 PITX2 TBX1 ZFPM2
33 multicellular organism development GO:0007275 10.11 CFAP53 CFC1 NKX1-2 NKX2-5 NKX2-6 PITX2
34 transcription from RNA polymerase II promoter GO:0006366 10.04 GATA4 GATA6 MED24 NKX2-5 PITX2 ZIC3
35 regulation of transcription from RNA polymerase II promoter GO:0006357 10.03 MED13L MED24 NKX2-5 NR2F2 PITX2 TBX1

Molecular functions related to Transposition of the Great Arteries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 GATA4 GATA6 NKX2-5 NR2F2 PITX2 TBX1
2 transcription factor binding GO:0008134 9.65 GATA4 GATA6 NKX2-5 PITX2 ZFPM2
3 transcription factor activity, sequence-specific DNA binding GO:0003700 9.56 GATA4 GATA6 NKX2-5 NKX2-6 NR2F2 PITX2
4 RNA polymerase II transcription factor binding GO:0001085 9.5 GATA4 GATA6 ZFPM2
5 RNA polymerase II transcription cofactor activity GO:0001104 9.33 MED13L MED24 NKX2-5
6 sequence-specific DNA binding GO:0043565 9.28 GATA4 GATA6 NKX1-2 NKX2-5 NKX2-6 NR2F2

Sources for Transposition of the Great Arteries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....