MCID: TRN007
MIFTS: 47

Transsexualism malady

Neuronal category

Summaries for Transsexualism

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards: Transsexualism is related to prolactinoma and klinefelter's syndrome. An important gene associated with Transsexualism is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Mineralocorticoid biosynthesis and Osteoblast Signaling. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include brain and adipocyte, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 Transsexualism describes the condition in which an individual identifies with a gender inconsistent or... more...

Aliases & Classifications for Transsexualism

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

transsexualism 8 10 61


External Ids:

Disease Ontology8 DOID:10919
ICD9CM27 302.50
SNOMED-CT57 191782007
ICD1025 F64.0

Related Diseases for Transsexualism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1prolactinoma30.1ESR2, PRL, GNRH1
2klinefelter's syndrome30.1CYP21A2, CYP19A1, SHBG, PRL, AR, GNRH1
3systemic lupus erythematosus29.9PRL
4hypoactive sexual desire disorder29.9SHBG
5anorexia nervosa29.9SHBG, PRL, TNFRSF11B, LSL
6hypospadias29.9SRD5A2, CYP21A2, CYP17A1, AR
7insulin resistance29.9ESR2, CYP21A2, CYP17A1, LIPC, SHBG, LPL
8adenoma29.8ESR2, CYP21A2, CYP17A1, SHBG, PRL, GNRH1
9infertility29.8ESR2, CYP21A2, CYP19A1, SHBG, PRL, AR
10osteoporosis29.8ESR2, CYP21A2, CYP19A1, SHBG, TNFRSF11B, TNFSF11
11transvestism10.5
12homocystinuria10.1
13venous thrombosis10.1
14hepatitis10.0SERPINA7
15acne10.0SHBG
16thyrotoxicosis10.0SERPINA7
17prostatitis10.0KLK3
18psoriasis10.0KLK6
19acute myocardial infarction10.0TNFSF11
20osteonecrosis10.0BGLAP
21periodontitis10.0TNFRSF11B
22bulimia nervosa10.0LSL
23fibrous dysplasia10.0BGLAP
24panhypopituitarism10.0PRL
25metabolic acidosis10.0BGLAP
26pancreatitis10.0LPL
27germinoma10.0CYP21A2
28hepatitis c10.0LPL
29diabetic ketoacidosis10.0LSL
30diabetes insipidus10.0PRL
31sarcoma10.0AR
32aromatase deficiency10.0CYP19A1
33nephrotic syndrome10.0LPL
34root resorption10.0TNFRSF11B
35cholestasis10.0LIPC
36multiple sclerosis10.0LSL
37congenital hypothyroidism10.0SERPINA7, CYP21A2
38migraine10.0CALCA
39arteriosclerosis10.0LPL
40abetalipoproteinemia10.0LPL
41mccune albright syndrome10.0GNRH1
42liver cirrhosis10.0SERPINA7, LSL
43marasmus10.0LSL
44uterine fibroid10.0GNRH1
45addison's disease10.0CYP21A2, CYP17A1
46multinodular goiter10.0CALCA
47alopecia10.0SHBG, AR
48hepatoblastoma10.0SHBG
49thyroiditis10.0SERPINA7, CALCA
50acanthosis nigricans10.0CYP21A2, SHBG

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Clinical Features for Transsexualism

Drugs & Therapeutics for Transsexualism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Transsexualism

Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Search CenterWatch for Transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Transsexualism:

33
Brain, Adipocyte

Animal Models for Transsexualism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Transsexualism

Sources:
51PubMed
See all sources

Articles related to Transsexualism:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. (23857518)
2014
2
Increased Cortical Thickness in Male-to-Female Transsexualism. (23724358)
2012
3
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? (21691959)
2011
4
Transsexualism--diagnostic and therapeutic aspects. (20806188)
2010
5
Regional gray matter variation in male-to-female transsexualism. (19341803)
2009
6
Quality of life 15 years after sex reassignment surgery for transsexualism. (18990387)
2009
7
Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism. (18190640)
2008
8
Sex steroid-related genes and male-to-female transsexualism. (15854782)
2005
9
The importance of the voice in male-to-female transsexualism. (15070236)
2004
10
Transsexualism and schizophrenia: a case report. (21206566)
2002
11
Kallmann's syndrome and transsexualism. (11286006)
2001
12
Transsexualism and osteoporosis. (9792472)
1998
13
Judicial problems related to transsexualism in France. (9029916)
1997
14
Four-year remission of transsexualism after comorbid obsessive-compulsive disorder improved with self-exposure therapy. Case report. (9373432)
1997
15
Further insights into transsexualism. (8711070)
1996
16
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
17
Transsexualism and gender reassignment. (7994532)
1994
18
Treatment of gender dysphoria (transsexualism). (8029771)
1994
19
Transsexualism and sex-related differences in hemispheric asymmetry. (8317258)
1993
20
The prevalence of transsexualism in The Netherlands. (8488743)
1993
21
Demanding subjectivity: transsexualism, medicine, and the technologies of gender. (11612877)
1992
22
Gene- and environment-dependent neuroendocrine etiogenesis of homosexuality and transsexualism. (1778227)
1991
23
Transsexualism. (1679156)
1991
24
Male transsexualism in mainland China. (2604543)
1989
25
Transsexualism: syndrome or symptom? (3319128)
1987
26
Transsexualism in India. (21927112)
1985
27
Transsexualism and physical deformity. (6481347)
1984
28
Transsexualism: a clinical approach to gender dysphoria. (6759840)
1982
29
Psychological adjustment in transvestism and transsexualism. (7316917)
1981
30
Cognitive correlates of biologic sex and gender identity in transsexualism. (7011255)
1981
31
Transsexualism: a legal perspective. (7420377)
1980
32
Verbal tests and transsexualism. (420030)
1979
33
Transsexualism and the law. (549698)
1979
34
Australian Transsexualism Committee. (318473)
1979
35
Transsexualism and a new type of psychosurgery. (738821)
1978-1979
36
Clinical comparison of transvestism and transsexualism: an overview. (269727)
1977
37
Transsexualism as a concretized manifestation of orality. (1275111)
1976
38
Male transsexualism in England: sixteen cases with surgical intervention. (1169047)
1975
39
Surgical approach to male transsexualism. (4836347)
1974
40
Editorial: Transvestism and transsexualism. (4827101)
1974
41
Female transsexualism: part I. (4429435)
1974
42
Male transsexualism: uneasiness. (4650382)
1972
43
Transsexualism: review of syndrome and presentation of possible successful therapeutic approach. (5054381)
1972
44
Family dynamics in male transsexualism. (5112328)
1971
45
Male transsexualism: An endocrine study. (24179050)
1971
46
Female transsexualism. (5546037)
1971
47
Two cases of transsexualism with gonadal dysgenesia. (5568201)
1971
48
Sex conversion operation in female transsexualism. (4179807)
1968
49
MALE PSYCHOSEXUAL INVERSION: TRANSSEXUALISM: A REVIEW OF 100 CASES. (14314763)
1965
50
Transsexualism: report of a case. (14427679)
1959

Genetic Variations for Transsexualism

Expression for genes affiliated with Transsexualism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP21A2, CYP17A1
210.1TNFRSF11B, TNFSF11
3
Hide members
10.1ESR2, CYP19A1
4
Hide members
10.0SRD5A2, SRD5A3, CYP17A1
5
Hide members
10.0CYP19A1, CYP17A1, CYP21A2
610.0CYP21A2, CYP17A1, CYP19A1
7
Transcription Androgen Receptor nuclear signaling
Hide members
10.0SRD5A2, AR, KLK3
89.9GNRH1, AR, SHBG
9
Development Prolactin receptor signaling
Hide members
9.7ESR2, CYP17A1, PRL, TNFSF11
10
Hide members
9.7CYP19A1, CYP17A1, CYP21A2, SRD5A3, SRD5A2
11
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.2CYP19A1, AR, TNFRSF11B, TNFSF11, CALCA, BGLAP

Compounds for genes affiliated with Transsexualism

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1estrogen4510.3KLK3, LIPC, SERPINA7
2goserelin45 29 1112.1LSL, GNRH1
3finasteride45 60 11 2412.8KLK3, AR, SHBG, CYP19A1, SRD5A3, SRD5A2
4bisphenol a459.7CYP19A1, AR, CYP17A1, SERPINA7, LPL, ESR2
5levonorgestrel45 60 29 1112.7PRL, SHBG, ESR2, CYP19A1, SERPINA7, AR
6ibandronate45 1110.7BGLAP, CALCA, TNFRSF11B, CYP19A1, TNFSF11
7spironolactone50 45 60 29 1113.7GNRH1, AR, SHBG, CYP21A2, SERPINA7, KLK3
817-hydroxyprogesterone45 2410.7GNRH1, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
9clomiphene citrate459.7SHBG, ESR2, CYP21A2, CYP19A1, PRL, GNRH1
10leuprolide45 60 29 1112.6AR, PRL, LSL, GNRH1, KLK3
11exemestane50 45 60 1112.6ESR2, CYP17A1, CYP19A1, SHBG, AR, BGLAP
12deoxypyridinoline459.6BGLAP, TNFRSF11B, TNFSF11, LSL, CALCA
13danazol45 11 2411.6GNRH1, AR, PRL, SHBG, LIPC, CYP19A1
14epinephrine45 11 2411.6CYP21A2, SHBG, PRL, LPL, LSL, CALCA
15leuprolide acetate459.6KLK3, GNRH1, SHBG, CYP19A1, CYP21A2, ESR2
163beta-hydroxysteroid459.5AR, CYP17A1, SRD5A2, CYP21A2, ESR2, CYP19A1
17flutamide45 60 1111.5CYP19A1, KLK3, GNRH1, TNFRSF11B, PRL, SHBG
1817beta-hydroxysteroid459.5CYP17A1, CYP21A2, SRD5A2, ESR2, CYP19A1, AR
19ketoconazole45 29 11 2412.5CYP21A2, CYP17A1, CYP19A1, SHBG, KLK3, AR
20diethylstilbestrol45 29 1111.5ESR2, CYP17A1, CYP19A1, SHBG, AR, GNRH1
21toremifene45 1110.5SHBG, ESR2, PRL, GNRH1, CYP19A1
22cyproteroneacetate459.5CYP19A1, SHBG, PRL, AR, GNRH1, BGLAP
23acth459.4PRL, LIPC, CYP17A1, CYP21A2, GNRH1, LSL
2425-hydroxyvitamin d459.4CYP19A1, SHBG, TNFRSF11B, TNFSF11, BGLAP, CALCA
25tibolone459.4LSL, GNRH1, CALCA, BGLAP, SHBG, CYP19A1
26progestin459.4GNRH1, AR, ESR2, PRL, SHBG, CYP19A1
27zoledronic acid459.4KLK3, BGLAP, CALCA, GNRH1, TNFSF11, CYP19A1
28progestins459.3GNRH1, KLK3, ESR2, CYP19A1, LIPC, SHBG
29buserelin45 29 1111.3KLK3, CYP19A1, PRL, GNRH1, CALCA
30corticosterone45 60 2411.2PRL, CALCA, CYP21A2, SERPINA7, BGLAP, LSL
31tamoxifen45 50 29 1112.2LSL, GNRH1, AR, LPL, CYP19A1, CYP17A1
32dehydroepiandrosterone sulfate459.2AR, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
33calcitriol45 60 11 2412.1CALCA, TNFSF11, BGLAP, LPL, AR, KLK3
34risedronate45 60 50 29 1113.1CALCA, CYP19A1, TNFRSF11B, TNFSF11, BGLAP
35gnrh459.1CYP21A2, CYP19A1, SHBG, AR, GNRH1, BGLAP
36hydrocortisone45 2 60 1112.0TNFRSF11B, PRL, SHBG, CYP19A1, CYP21A2, LSL
37dexamethasone45 50 29 1111.9LPL, SHBG, CYP17A1, CYP21A2, AR, TNFRSF11B
38androstenedione45 249.9AR, GNRH1, LSL, PRL, SHBG, ESR2
39estradiol45 11 2410.9PRL, KLK3, ESR2, GNRH1, SHBG, LIPC
40genistein45 29 60 2 11 2413.8CYP17A1, CYP19A1, ESR2, CYP21A2, LPL, TNFRSF11B
41dhea458.8SHBG, PRL, ESR2, CYP21A2, CYP17A1, CYP19A1
42raloxifene45 29 50 1111.8TNFRSF11B, SHBG, CYP19A1, SERPINA7, ESR2, TNFSF11
43estrone45 29 11 2411.6AR, GNRH1, LSL, BGLAP, ESR2, SERPINA7
44progesterone45 60 29 11 2412.6SRD5A2, PRL, LSL, GNRH1, CYP17A1, ESR2
45vitamin d458.6CYP19A1, CYP17A1, SRD5A2, ESR2, SHBG, KLK3
46thyroxine45 249.4SERPINA7, CYP21A2, KLK3, BGLAP, CALCA, LSL
47dihydrotestosterone45 29 11 2411.4CYP21A2, SRD5A2, ESR2, CYP17A1, CYP19A1, SHBG
48arginine458.2ESR2, SHBG, SERPINA7, LIPC, CYP19A1, CYP17A1
49steroid457.8LSL, GNRH1, TNFSF11, TNFRSF11B, AR, PRL
50testosterone45 60 11 2410.2KLK3, BGLAP, CALCA, LSL, GNRH1, TNFSF11

GO Terms for genes affiliated with Transsexualism

Sources:
16Gene Ontology
See all sources

Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8CALCA, GNRH1, TNFSF11, TNFRSF11B, LPL, LIPC
2extracellular regionGO:0055767.7ESR2, KLK6, KLK3, BGLAP, CALCA, GNRH1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.3CYP17A1, SRD5A3, SRD5A2
2prostate gland growthGO:06073610.2CYP19A1, AR
3very-low-density lipoprotein particle remodelingGO:03437210.2LIPC, LPL
4glucocorticoid biosynthetic processGO:00670410.2CYP17A1, CYP21A2
5sterol metabolic processGO:01612510.2CYP21A2, CYP17A1, CYP19A1
6ovulation cycleGO:04269810.1GNRH1, PRL
7negative regulation of bone resorptionGO:04577910.0TNFRSF11B, CALCA
8steroid metabolic processGO:0082029.9SRD5A2, SRD5A3, CYP21A2, CYP17A1, CYP19A1
9prostate gland epithelium morphogenesisGO:0607409.8ESR2, AR
10response to ethanolGO:0454719.7PRL, GNRH1, BGLAP
11cell-cell signalingGO:0072679.6CALCA, GNRH1, AR, SRD5A2, ESR2
12response to drugGO:0424939.6BGLAP, TNFRSF11B, LPL, PRL, CYP17A1, SERPINA7

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A3
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2, SRD5A3
3androgen bindingGO:00549710.0AR, SHBG
4hormone activityGO:0051799.8PRL, GNRH1, CALCA
5phospholipase activityGO:0046209.7LIPC, LPL

Products for genes affiliated with Transsexualism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Transsexualism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet