Aliases & Classifications for Transsexualism

MalaCards integrated aliases for Transsexualism:

Name: Transsexualism 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 34 302.50
SNOMED-CT 64 191782007
ICD10 32 F64.0
UMLS 69 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to vaginitis and hyperandrogenism. An important gene associated with Transsexualism is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Nuclear Receptor transcription pathway and Metabolism of steroid hormones. The drugs Testosterone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are adipose tissue and growth/size/body region

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 vaginitis 29.8 AR ESR2
2 hyperandrogenism 29.2 CYP17A1 CYP19A1 CYP21A2
3 polycystic ovary syndrome 29.2 CYP17A1 CYP19A1 CYP21A2
4 osteoporosis 28.9 AR CYP19A1 ESR2
5 gender identity disorder 28.6 AR CYP19A1 ESR2 RFX6 RPGRIP1L
6 transsexuality 12.1
7 postmenopausal atrophic vaginitis 10.3 AR ESR2
8 malignant germ cell tumor 10.3 AR ESR2
9 androgen insensitivity, partial 10.3 AR CYP19A1
10 progesterone-receptor positive breast cancer 10.2 CYP19A1 ESR2
11 testicular germ cell cancer 10.2 AR ESR2
12 prostatic hyperplasia, benign 10.2 AR CYP19A1
13 estrogen excess 10.2 CYP19A1 ESR2
14 androgenic alopecia 10.2 AR CYP19A1
15 complete androgen insensitivity syndrome 10.2 AR CYP19A1
16 penis agenesis 10.2 AR CYP17A1
17 endometriosis of ovary 10.2 CYP19A1 ESR2
18 transvestism 10.2
19 prostatic hypertrophy 10.2 AR CYP19A1
20 prostate disease 10.2 AR CYP19A1
21 gynecomastia 10.1 AR CYP19A1
22 mammographic density 10.1 CYP17A1 CYP19A1
23 mycetoma 10.1 CYP17A1 CYP19A1
24 testicular germ cell tumor 10.1 AR ESR2
25 luteoma 10.1 CYP19A1 CYP21A2
26 ductal carcinoma in situ 10.1 AR CYP19A1
27 cytochrome p450 oxidoreductase deficiency 10.0 CYP17A1 CYP21A2
28 endocrine gland cancer 10.0 AR CYP19A1
29 testicular leydig cell tumor 10.0 CYP17A1 CYP21A2
30 steroid inherited metabolic disorder 10.0 CYP17A1 CYP21A2
31 precocious puberty 10.0 CYP19A1 CYP21A2
32 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.0 CYP17A1 CYP21A2
33 reproductive system disease 10.0 AR CYP19A1 ESR2
34 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 9.9 CYP17A1 CYP21A2
35 adrenal cortical adenoma 9.9 CYP17A1 CYP21A2
36 male reproductive organ cancer 9.9 AR CYP17A1 ESR2
37 reproductive organ cancer 9.9 AR CYP17A1 ESR2
38 pseudohermaphroditism 9.9 AR CYP17A1 CYP19A1
39 adrenal adenoma 9.9 CYP17A1 CYP21A2
40 cryptorchidism, unilateral or bilateral 9.9 AR CYP19A1
41 adrenal carcinoma 9.9 CYP17A1 CYP21A2
42 leiomyoma, uterine 9.9 CYP17A1 CYP19A1 ESR2
43 female reproductive system disease 9.9 CYP17A1 CYP19A1 ESR2
44 lipoid congenital adrenal hyperplasia 9.9 CYP17A1 CYP21A2
45 schizophrenia 9.9
46 pituitary adenoma, prolactin-secreting 9.9
47 prostatitis 9.9
48 alopecia, androgenetic, 1 9.8 AR CYP19A1 CYP21A2
49 blood group, i system 9.8
50 thrombophilia due to thrombin defect 9.8

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.85 ESR2 AR RPGRIP1L CYP17A1 CYP19A1
2 growth/size/body region MP:0005378 9.85 CYP19A1 ESR2 AR RFX6 CYP17A1 RPGRIP1L
3 digestive/alimentary MP:0005381 9.83 ESR2 AR RFX6 RPGRIP1L CYP19A1
4 endocrine/exocrine gland MP:0005379 9.8 CYP19A1 ESR2 AR RFX6 RPGRIP1L
5 homeostasis/metabolism MP:0005376 9.8 CYP19A1 ESR2 RFX6 AR CYP17A1 RPGRIP1L
6 liver/biliary system MP:0005370 9.56 CYP19A1 ESR2 AR RPGRIP1L
7 renal/urinary system MP:0005367 9.55 ESR2 AR RPGRIP1L CYP17A1 CYP19A1
8 reproductive system MP:0005389 9.35 ESR2 AR CYP17A1 RPGRIP1L CYP19A1
9 skeleton MP:0005390 9.02 CYP19A1 ESR2 AR CYP17A1 RPGRIP1L

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
3 Lynestrenol Approved, Investigational Phase 4 52-76-6
4
Testolactone Approved, Investigational Phase 4 968-93-4 13769
5
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
6
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
7 Testosterone undecanoate Phase 4,Phase 3
8 Estradiol valerate Phase 4,Phase 3 979-32-8
9
Serotonin Phase 4 50-67-9 5202
10
Testosterone enanthate Phase 4,Phase 3 315-37-7 9416
11
Cyproterone Phase 4 2098-66-0 5284537
12 5-alpha Reductase Inhibitors Phase 4,Phase 3
13 Serotonin Agents Phase 4
14 Steroid Synthesis Inhibitors Phase 4,Phase 3
15 Testosterone 17 beta-cypionate Phase 4,Phase 3
16 Neurotransmitter Agents Phase 4
17 Contraceptive Agents Phase 4
18 Contraceptive Agents, Male Phase 4
19 Contraceptives, Oral Phase 4
20 Androgen Antagonists Phase 4
21 Androgens Phase 4,Phase 3
22 Hormone Antagonists Phase 4,Phase 3
23 Hormones Phase 4,Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
25 Estradiol 17 beta-cypionate Phase 4,Phase 3
26 Estradiol 3-benzoate Phase 4,Phase 3
27 Estrogens Phase 4,Phase 3
28 Polyestradiol phosphate Phase 4,Phase 3
29 Antineoplastic Agents, Hormonal Phase 4,Phase 3
30
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
31
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
32
Dihydrotestosterone Phase 3 521-18-6 10635
33 Anabolic Agents Phase 3
34 Estrogen Antagonists Phase 3
35 Aromatase Inhibitors Phase 3
36
Hydrocortisone Approved, Vet_approved 50-23-7 657311 5754
37
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
38 Cortisol succinate
39 Vitamins
40 Hydrocortisone 17-butyrate 21-propionate
41 Hydrocortisone acetate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sex Steroids and the Serotonin Transporter Completed NCT01065220 Phase 4 Testolactone undecanoate;Lynestrenol;Cyproterone Acetate;Estradiol;5-alpha reductase inhibitor
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism Completed NCT00435513 Early Phase 1
4 First Australian National Trans Mental Health Study Completed NCT02119377
5 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
6 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
7 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
8 A European Network for the Investigation of Gender Incongruence Recruiting NCT01072825

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

38
Bone, Testes, Brain, Ovary, Prostate, Breast, Pituitary

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 354)
# Title Authors Year
1
The Pattern of Sexual Interest of Female-to-Male Transsexual Persons With Gender Identity Disorder Does Not Resemble That of Biological Men: An Eye-Tracking Study. ( 28823313 )
2017
2
Prevalence, Incidence, and Sex Ratio of Transsexualism in the Autonomous Region of Madrid (Spain) According to Healthcare Demand. ( 28224311 )
2017
3
Reduced serum concentrations of brain-derived neurotrophic factor (BDNF) in transsexual Brazilian men. ( 27473941 )
2016
4
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. ( 27578416 )
2016
5
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. ( 27817755 )
2016
6
A Review of the Status of Brain Structure Research in Transsexualism. ( 27255307 )
2016
7
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. ( 27649696 )
2016
8
AntimA1llerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy. ( 25772768 )
2015
9
Sociodemographic Study of Danish Individuals Diagnosed with Transsexualism. ( 26185676 )
2015
10
"Living in a Shell of Something I'm Not": Transsexuality, Medical Ethics, and the Judeo-Christian Culture. ( 26156704 )
2015
11
Systematic review and meta-analysis of prevalence studies in transsexualism. ( 26021270 )
2015
12
The transsexual brain - A review of findings on the neural basis of transsexualism. ( 26429593 )
2015
13
Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. ( 24134805 )
2014
14
Bilateral Non-arteritic Ischemic Optic Neuropathy in a Transsexual Woman Using Excessive Estrogen Dosage. ( 24057212 )
2014
15
Diagnosis of prolactinoma in two male-to-female transsexual subjects following high-dose cross-sex hormone therapy. ( 25059808 )
2014
16
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. ( 24680383 )
2014
17
Treatment of anorexia nervosa in the context of transsexuality: A case report. ( 24323528 )
2014
18
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. ( 23857518 )
2014
19
The invisibility of gender diversity: understanding transgender and transsexuality in nursing literature. ( 24387331 )
2014
20
Challenges in the diagnosis and treatment of transsexualism in contemporary China. ( 25114481 )
2014
21
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. ( 25124466 )
2014
22
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. ( 23897544 )
2013
23
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. ( 23809495 )
2013
24
The (CA)n Polymorphism of ERI^ Gene is Associated with FtM Transsexualism. ( 24274329 )
2013
25
Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual. ( 23022362 )
2013
26
The "Auto" (Self) in Autogynephilic Transsexualism Men Trapped in Men's Bodies: Narratives of Autogynephilic Transsexualism. By Anne A. Lawrence. New York, NY: Springer, 2013, 242 pages. Cloth, $129.00. ( 24171550 )
2013
27
Hypogonadism in a male-to-female transsexual with super obesity. ( 22783836 )
2013
28
More evidence that societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 23377823 )
2013
29
Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. ( 24329588 )
2013
30
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. ( 23970664 )
2013
31
On the quest for a biomechanism of transsexualism: is there a role for BDNF? ( 24070909 )
2013
32
Hysterectomy and bilateral adnexectomy by laparoscopic single port access for female to male transsexualism. ( 23433319 )
2013
33
Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review. ( 23916699 )
2013
34
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
35
Increased Cortical Thickness in Male-to-Female Transsexualism. ( 23724358 )
2012
36
Karyotyping, is it worthwhile in transsexualism? ( 21114769 )
2011
37
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? ( 21691959 )
2011
38
Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. ( 21477021 )
2011
39
New MRI studies support the Blanchard typology of male-to-female transsexualism. ( 21739338 )
2011
40
Glottoplasty for male-to-female transsexualism: voice results. ( 20171832 )
2011
41
Human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in Argentina. ( 21511521 )
2011
42
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. ( 21074005 )
2011
43
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. ( 21078006 )
2010
44
Male-to-female transsexualism: technique, results and 3-year follow-up in 50 patients. ( 20389165 )
2010
45
Transsexualism. ( 20642030 )
2010
46
Prolactinoma induced by estrogen and cyproterone acetate in a male-to-female transsexual. ( 20227072 )
2010
47
Transsexualism - attitudes in general practice. ( 20372674 )
2010
48
Vaginal carcinoma in a female-to-male transsexual. ( 20102482 )
2010
49
Emphysematous Pyelonephritis in a non-diabetic post-operative Transsexual patient. ( 21597566 )
2010
50
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. ( 19620824 )
2010

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.37 AR ESR2
2 sex differentiation GO:0007548 9.32 AR CYP17A1
3 prostate gland growth GO:0060736 9.26 AR CYP19A1
4 glucocorticoid biosynthetic process GO:0006704 9.16 CYP17A1 CYP21A2
5 steroid biosynthetic process GO:0006694 9.13 CYP17A1 CYP19A1 CYP21A2
6 sterol metabolic process GO:0016125 8.8 CYP17A1 CYP19A1 CYP21A2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.58 AR CYP21A2 ESR2
2 steroid hormone receptor activity GO:0003707 9.46 AR ESR2
3 oxygen binding GO:0019825 9.43 CYP17A1 CYP19A1
4 iron ion binding GO:0005506 9.43 CYP17A1 CYP19A1 CYP21A2
5 nuclear receptor activity GO:0004879 9.37 AR ESR2
6 heme binding GO:0020037 9.33 CYP17A1 CYP19A1 CYP21A2
7 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP21A2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP17A1 CYP19A1 CYP21A2
9 steroid binding GO:0005496 8.8 AR CYP21A2 ESR2

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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