MCID: TRN007
MIFTS: 53

Transsexualism malady

Neuronal diseases category

Summaries for Transsexualism

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards: Transsexualism is related to prostatitis and schizophrenia. An important gene associated with Transsexualism is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Mineralocorticoid biosynthesis and Osteoblast Signaling. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 Transsexualism is when an individual identifies with a gender inconsistent or not culturally associated... more...

Aliases & Classifications for Transsexualism

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

transsexualism 8 10 60


External Ids:

Disease Ontology8 DOID:10919
ICD9CM27 302.50
SNOMED-CT56 191782007
ICD1025 F64.0

Related Diseases for Transsexualism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.2KLK3
2schizophrenia30.1ESR2, PRL
3ovarian disease30.0SHBG, PRL, GNRH1
4prolactinoma30.0ESR2, PRL, GNRH1
5klinefelter's syndrome30.0CYP21A2, CYP19A1, SHBG, PRL, AR, GNRH1
6hepatitis29.8SERPINA7
7systemic lupus erythematosus29.8PRL
8hepatitis c29.8LPL
9hypoactive sexual desire disorder29.8SHBG
10thyroiditis29.8SERPINA7, CALCA
11prostate cancer29.8AR, KLK3
12anorexia nervosa29.8SHBG, PRL, TNFRSF11B, LSL
13hypospadias29.8SRD5A2, CYP21A2, CYP17A1, AR
14sexual disorder29.8SHBG, PRL, GNRH1, KLK3
15pituitary adenoma29.8ESR2, SERPINA7, PRL, GNRH1
16obesity29.8CYP21A2, LIPC, SHBG, LPL, AR, LSL
17adenoma29.8ESR2, CYP21A2, CYP17A1, SHBG, PRL, GNRH1
18hyperandrogenism29.8CYP21A2, CYP17A1, CYP19A1, SHBG, PRL, AR
19infertility29.8ESR2, CYP21A2, CYP19A1, SHBG, PRL, AR
20osteoporosis29.8ESR2, CYP21A2, CYP19A1, SHBG, TNFRSF11B, TNFSF11
21hypogonadism29.8CYP19A1, SHBG, PRL, AR, GNRH1, LSL
22transvestism10.5
23gender identity disorder10.2
24homocystinuria10.0
25fetishism10.0
26acne10.0SHBG
27thyrotoxicosis10.0SERPINA7
28psoriasis10.0KLK6
29acute myocardial infarction10.0TNFSF11
30osteonecrosis10.0BGLAP
31periodontitis10.0TNFRSF11B
32bulimia nervosa10.0LSL
33fibrous dysplasia10.0BGLAP
34panhypopituitarism10.0PRL
35metabolic acidosis10.0BGLAP
36pancreatitis10.0LPL
37germinoma10.0CYP21A2
38diabetic ketoacidosis10.0LSL
39diabetes insipidus10.0PRL
40sarcoma10.0AR
41aromatase deficiency10.0CYP19A1
42root resorption10.0TNFRSF11B
43nephrotic syndrome10.0LPL
44cholestasis10.0LIPC
45multiple sclerosis10.0LSL
46congenital hypothyroidism10.0SERPINA7, CYP21A2
47migraine10.0CALCA
48arteriosclerosis10.0LPL
49abetalipoproteinemia10.0LPL
50mccune albright syndrome10.0GNRH1

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Clinical Features for Transsexualism

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Drugs & Therapeutics for Transsexualism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Transsexualism

Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Search CenterWatch for Transsexualism

Genetic Tests for Transsexualism

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Anatomical Context for Transsexualism

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Sources:
32MalaCards
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MalaCards organs/tissues related to Transsexualism:

32
Bone, Breast, Testes, Prostate, Ovary, Pituitary, Thyroid, Adipocyte, Brain, Cervix

Animal Models for Transsexualism or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Transsexualism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9ESR2, SRD5A2, LIPC
2MP:00053899.8SRD5A2, LIPC, PRL, GNRH1
3MP:00107719.4CALCA, GNRH1, TNFSF11, AR, LPL
4MP:00053709.2ESR2, CYP19A1, PRL, LPL, AR, GNRH1
5MP:00053909.0GNRH1, TNFSF11, TNFRSF11B, AR, CYP19A1, ESR2
6MP:00053768.3CALCA, GNRH1, TNFSF11, AR, LPL, PRL

Publications for Transsexualism

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Sources:
50PubMed
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Articles related to Transsexualism:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. (21078006)
2010
2
Unilateral hypoplastic breast in a male-to-female transsexual with Poland syndrome after gender reassignment--reconstructive considerations. (18639510)
2009
3
A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism. (17765230)
2008
4
Shame and narcissistic rage in autogynephilic transsexualism. (18431633)
2008
5
Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females. (17971101)
2008
6
A common polymorphism of the SRD5A2 gene and transsexualism. (18000232)
2007
7
Psychotherapy and transsexualism. (18076425)
2007
8
Prevalence and demography of transsexualism in Belgium. (17188846)
2007
9
Two monozygotic twin pairs discordant for female-to-male transsexualism. (16802182)
2006
10
Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. (16320157)
2005
11
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
12
Masculinity, femininity, and transsexualism. (12462479)
2002
13
Transsexualism - need it always be a DSM-IV disorder. (11929453)
2002
14
Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones. (9578826)
1998
15
A higher rate of hyperandrogenic disorders in female-to-male transsexuals. (9279941)
1997
16
Incidence and sex ratio of transsexualism in Sweden. (8712025)
1996
17
Homocystinuria and transsexualism. (8637371)
1996
18
Prevalence, incidence and sex ratio of transsexualism. (8712018)
1996
19
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
20
The effect of non-steroidal antiandrogen flutamide on luteinizing hormone pulsatile secretion in male-to-female transsexual subjects. (7594235)
1995
21
Transsexualism and gender reassignment. (7994532)
1994
22
A female monozygotic twin pair discordant for transsexualism. Some theoretical implications. (1483176)
1992
23
17 beta-Oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals. (1424181)
1992
24
Existence of transsexualism in the military setting. (2774899)
1989
25
Typology of male-to-female transsexualism. (4004548)
1985
26
The role of surgery in the treatment of transsexualism. (6524842)
1984
27
Transsexualism observed. (6809123)
1982
28
Partnership in transsexualism. Part II. The nature of the partnership. (7247724)
1981
29
Female transsexualism in Singapore: a report on 20 cases. (6932869)
1980
30
Medicolegal aspects of transsexualism. (7382786)
1980
31
Transsexualism. (7347816)
1980
32
Verbal tests and transsexualism. (420030)
1979
33
Behavioral treatment of transsexualism: a case report. (43401)
1979
34
Medicolegal aspects of transsexualism. (1024695)
1976
35
The management of transsexualism. (1012115)
1976
36
Male transsexualism. Confirmation of a hypothesis? (1200778)
1975
37
Male transsexualism in England: sixteen cases with surgical intervention. (1169047)
1975
38
Transsexualism in history. (1103789)
1975
39
The transsexual syndrome in males. I. Primary transsexualism. (4812111)
1974
40
Female transsexualism: part II. (4429436)
1974
41
Transvestitism and transsexualism. (4751012)
1973
42
Family dynamics in male transsexualism. (5112328)
1971
43
Male transsexualism: An endocrine study. (24179050)
1971
44
Two cases of transsexualism with gonadal dysgenesia. (5568201)
1971
45
Social and economic aspects of transsexualism. (5480670)
1970
46
The desire for sexual transformation: a psychiatric evaluation of transsexualism. (5772927)
1969
47
NATURE AND MANAGEMENT OF TRANSSEXUALISM, WITH A REPORT ON THIRTY-ONE OPERATED CASES. (14128591)
1964
48
CLINICAL ASPECTS OF TRANSSEXUALISM IN THE MALE AND FEMALE. (14173773)
1964
49
A study in transsexualism. (13708262)
1960
50
Homosexuality, transvestism and transsexualism; reflections on their etiology and differentiation. (13394762)
1957

Genetic Variations for Transsexualism

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Expression for genes affiliated with Transsexualism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP21A2, CYP17A1
210.1TNFRSF11B, TNFSF11
3
Hide members
10.1ESR2, CYP19A1
4
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10.0SRD5A2, SRD5A3, CYP17A1
5
Hide members
10.0CYP19A1, CYP17A1, CYP21A2
610.0CYP21A2, CYP17A1, CYP19A1
7
Transcription Androgen Receptor nuclear signaling
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10.0SRD5A2, AR, KLK3
89.9GNRH1, AR, SHBG
9
Development Prolactin receptor signaling
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9.7ESR2, CYP17A1, PRL, TNFSF11
10
Hide members
9.7CYP19A1, CYP17A1, CYP21A2, SRD5A3, SRD5A2
11
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.2CYP19A1, AR, TNFRSF11B, TNFSF11, CALCA, BGLAP

Compounds for genes affiliated with Transsexualism

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3KLK3, LIPC, SERPINA7
2goserelin44 28 1112.1LSL, GNRH1
3finasteride44 59 11 2412.8KLK3, AR, SHBG, CYP19A1, SRD5A3, SRD5A2
4bisphenol a449.7CYP19A1, AR, CYP17A1, SERPINA7, LPL, ESR2
5levonorgestrel44 59 28 1112.7PRL, SHBG, ESR2, CYP19A1, SERPINA7, AR
6ibandronate44 1110.7BGLAP, CALCA, TNFRSF11B, CYP19A1, TNFSF11
7spironolactone49 44 59 28 1113.7GNRH1, AR, SHBG, CYP21A2, SERPINA7, KLK3
817-hydroxyprogesterone44 2410.7GNRH1, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
9clomiphene citrate449.7SHBG, ESR2, CYP21A2, CYP19A1, PRL, GNRH1
10leuprolide44 59 28 1112.6AR, PRL, LSL, GNRH1, KLK3
11exemestane49 44 59 1112.6ESR2, CYP17A1, CYP19A1, SHBG, AR, BGLAP
12deoxypyridinoline449.6BGLAP, TNFRSF11B, TNFSF11, LSL, CALCA
13danazol44 11 2411.6GNRH1, AR, PRL, SHBG, LIPC, CYP19A1
14epinephrine44 11 2411.6CYP21A2, SHBG, PRL, LPL, LSL, CALCA
15leuprolide acetate449.6KLK3, GNRH1, SHBG, CYP19A1, CYP21A2, ESR2
163beta-hydroxysteroid449.5AR, CYP17A1, SRD5A2, CYP21A2, ESR2, CYP19A1
17flutamide44 59 1111.5CYP19A1, KLK3, GNRH1, TNFRSF11B, PRL, SHBG
1817beta-hydroxysteroid449.5CYP17A1, CYP21A2, SRD5A2, ESR2, CYP19A1, AR
19ketoconazole44 28 11 2412.5CYP21A2, CYP17A1, CYP19A1, SHBG, KLK3, AR
20diethylstilbestrol44 28 1111.5ESR2, CYP17A1, CYP19A1, SHBG, AR, GNRH1
21toremifene44 1110.5SHBG, ESR2, PRL, GNRH1, CYP19A1
22cyproteroneacetate449.5CYP19A1, SHBG, PRL, AR, GNRH1, BGLAP
23acth449.4PRL, LIPC, CYP17A1, CYP21A2, GNRH1, LSL
2425-hydroxyvitamin d449.4CYP19A1, SHBG, TNFRSF11B, TNFSF11, BGLAP, CALCA
25tibolone449.4LSL, GNRH1, CALCA, BGLAP, SHBG, CYP19A1
26progestin449.4GNRH1, AR, ESR2, PRL, SHBG, CYP19A1
27zoledronic acid449.4KLK3, BGLAP, CALCA, GNRH1, TNFSF11, CYP19A1
28progestins449.3GNRH1, KLK3, ESR2, CYP19A1, LIPC, SHBG
29buserelin44 28 1111.3KLK3, CYP19A1, PRL, GNRH1, CALCA
30corticosterone44 59 2411.2PRL, CALCA, CYP21A2, SERPINA7, BGLAP, LSL
31tamoxifen44 49 28 1112.2LSL, GNRH1, AR, LPL, CYP19A1, CYP17A1
32dehydroepiandrosterone sulfate449.2AR, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
33calcitriol44 59 11 2412.1CALCA, TNFSF11, BGLAP, LPL, AR, KLK3
34risedronate44 59 49 28 1113.1CALCA, CYP19A1, TNFRSF11B, TNFSF11, BGLAP
35gnrh449.1CYP21A2, CYP19A1, SHBG, AR, GNRH1, BGLAP
36hydrocortisone44 2 59 1112.0TNFRSF11B, PRL, SHBG, CYP19A1, CYP21A2, LSL
37dexamethasone44 49 28 1111.9LPL, SHBG, CYP17A1, CYP21A2, AR, TNFRSF11B
38androstenedione44 249.9AR, GNRH1, LSL, PRL, SHBG, ESR2
39estradiol44 11 2410.9PRL, KLK3, ESR2, GNRH1, SHBG, LIPC
40genistein44 28 59 2 11 2413.8CYP17A1, CYP19A1, ESR2, CYP21A2, LPL, TNFRSF11B
41dhea448.8SHBG, PRL, ESR2, CYP21A2, CYP17A1, CYP19A1
42raloxifene44 28 49 1111.8TNFRSF11B, SHBG, CYP19A1, SERPINA7, ESR2, TNFSF11
43estrone44 28 11 2411.6AR, GNRH1, LSL, BGLAP, ESR2, SERPINA7
44progesterone44 59 28 11 2412.6SRD5A2, PRL, LSL, GNRH1, CYP17A1, ESR2
45vitamin d448.6CYP19A1, CYP17A1, SRD5A2, ESR2, SHBG, KLK3
46thyroxine44 249.4SERPINA7, CYP21A2, KLK3, BGLAP, CALCA, LSL
47dihydrotestosterone44 28 11 2411.4CYP21A2, SRD5A2, ESR2, CYP17A1, CYP19A1, SHBG
48arginine448.2ESR2, SHBG, SERPINA7, LIPC, CYP19A1, CYP17A1
49steroid447.8LSL, GNRH1, TNFSF11, TNFRSF11B, AR, PRL
50testosterone44 59 11 2410.2KLK3, BGLAP, CALCA, LSL, GNRH1, TNFSF11

GO Terms for genes affiliated with Transsexualism

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16Gene Ontology
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Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8CALCA, GNRH1, TNFSF11, TNFRSF11B, LPL, LIPC
2extracellular regionGO:0055767.7ESR2, KLK6, KLK3, BGLAP, CALCA, GNRH1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.3CYP17A1, SRD5A3, SRD5A2
2prostate gland growthGO:06073610.2CYP19A1, AR
3very-low-density lipoprotein particle remodelingGO:03437210.2LIPC, LPL
4glucocorticoid biosynthetic processGO:00670410.2CYP17A1, CYP21A2
5sterol metabolic processGO:01612510.2CYP21A2, CYP17A1, CYP19A1
6ovulation cycleGO:04269810.1GNRH1, PRL
7negative regulation of bone resorptionGO:04577910.0TNFRSF11B, CALCA
8steroid metabolic processGO:0082029.9SRD5A2, SRD5A3, CYP21A2, CYP17A1, CYP19A1
9prostate gland epithelium morphogenesisGO:0607409.8ESR2, AR
10response to ethanolGO:0454719.7PRL, GNRH1, BGLAP
11cell-cell signalingGO:0072679.6CALCA, GNRH1, AR, SRD5A2, ESR2
12response to drugGO:0424939.6BGLAP, TNFRSF11B, LPL, PRL, CYP17A1, SERPINA7

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A3
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2, SRD5A3
3androgen bindingGO:00549710.0AR, SHBG
4hormone activityGO:0051799.8PRL, GNRH1, CALCA
5phospholipase activityGO:0046209.7LIPC, LPL

Products for genes affiliated with Transsexualism

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  • Antibodies
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Sources for Transsexualism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet