MCID: TRN007
MIFTS: 50

Transsexualism malady

Mental diseases category
Download this MalaCard

Summaries for Transsexualism

About this section


Fully expand this MalaCard
Disease Ontology:8 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary: Transsexualism is related to klinefelter's syndrome and osteoporosis. An important gene associated with Transsexualism is SRD5A3 (steroid 5 alpha-reductase 3), and among its related pathways are Ovarian steroidogenesis and Estrone metabolism. The compounds pregnanediol and es 936 have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:65 Transsexualism is when an individual identifies with a gender inconsistent or not culturally associated... more...

Aliases & Classifications for Transsexualism

About this section

Transsexualism, Aliases & Descriptions:

Name: Transsexualism 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:10919
ICD9CM27 302.50
SNOMED-CT57 191782007
ICD1025 F64.0

Related Diseases for Transsexualism

About this section

Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1klinefelter's syndrome29.9CYP19A1, CYP21A2, AR
2osteoporosis29.8CYP19A1, CYP21A2, ESR2
3hypogonadism29.8CYP19A1, AR
4insulin resistance29.8ESR2, CYP21A2, CYP17A1
5hyperandrogenism29.7AR, CYP21A2, CYP19A1, CYP17A1
6adenoma29.7ESR2, CYP21A2, CYP17A1
7polycystic ovary syndrome29.5CYP17A1, CYP19A1, CYP21A2, AR
8hypospadias29.5CYP17A1, CYP21A2, SRD5A2, AR
9infertility29.3CYP19A1, CYP21A2, ESR2, AR
10prostate cancer29.0CYP17A1, CYP19A1, ESR2, SRD5A2, AR
11transvestism10.5
12gender identity disorder10.3
13autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.2CYP17A1, CYP21A2
14conn's syndrome10.2CYP21A2, CYP17A1
15hyperaldosteronism10.2CYP17A1, CYP21A2
16alopecia10.2AR
17schizophrenia10.2
18prolactinoma10.2
19prostatitis10.2
20anovulation10.2CYP19A1, CYP21A2
21addison's disease10.2CYP21A2, CYP17A1
22precocious puberty10.2CYP21A2, CYP19A1
23cushing's syndrome10.2CYP21A2, CYP17A1
24ovarian cyst10.1CYP19A1, ESR2
25endometrial stromal sarcoma10.1ESR2, CYP19A1
26homocystinuria10.1
27fetishism10.1
28ovarian disease10.1
29venous thrombosis10.1
30li-fraumeni syndrome10.1ESR2, CYP19A1
31osteoporosis, postmenopausal10.1ESR2, CYP19A1
32antley-bixler syndrome10.1CYP21A2, CYP19A1, CYP17A1
33endocrine gland cancer10.1CYP19A1, AR
34adrenal adenoma10.1CYP21A2, CYP19A1, CYP17A1
35androgen insensitivity syndrome10.1CYP19A1, AR
36congenital adrenal hyperplasia10.0CYP21A2, CYP19A1, CYP17A1
37partial androgen insensitivity syndrome10.0CYP19A1, AR
38leydig cell tumor10.0CYP17A1, CYP19A1, CYP21A2
39adrenocortical carcinoma10.0CYP17A1, CYP19A1, CYP21A2
40adrenal cortical adenoma10.0CYP21A2, CYP19A1, CYP17A1
41short stature10.0CYP21A2, CYP19A1
42prostate disease10.0AR, CYP19A1
43sertoli cell tumor10.0CYP19A1, AR
44germ cell cancer10.0AR, ESR2
45cryptorchidism10.0AR, CYP19A1
46breast ductal carcinoma10.0AR, ESR2
47leiomyoma10.0ESR2, CYP19A1, CYP17A1
48endometriosis10.0ESR2, CYP19A1, CYP17A1
49hepatitis9.9
50hepatitis b9.9

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Symptoms for Transsexualism

About this section

Drugs & Therapeutics for Transsexualism

About this section

Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

About this section

Anatomical Context for Transsexualism

About this section

MalaCards organs/tissues related to Transsexualism:

32
Bone, Breast, Testes, Ovary, Prostate, Pituitary, Brain, Adipocyte, Thyroid, Cervix

Animal Models for Transsexualism or affiliated genes

About this section

MGI Mouse Phenotypes related to Transsexualism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5AR, ESR2, CYP19A1
2MP:00053797.7CYP19A1, ESR2, SRD5A2, AR
3MP:00053897.5AR, SRD5A2, ESR2, CYP19A1, CYP17A1

Publications for Transsexualism

About this section

Articles related to Transsexualism:

(show top 50)    (show all 323)
idTitleAuthorsYear
1
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. (25124466)
2014
2
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. (24680383)
2014
3
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. (23857518)
2014
4
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. (23809495)
2013
5
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. (23970664)
2013
6
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. (23897544)
2013
7
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
8
Karyotyping, is it worthwhile in transsexualism? (21114769)
2011
9
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. (19620824)
2010
10
Transsexualism--diagnostic and therapeutic aspects. (20806188)
2010
11
Transsexualism in Australia: a further statistic. (19227577)
2009
12
A common polymorphism of the SRD5A2 gene and transsexualism. (18000232)
2007
13
Effects of long-term androgen administration on breast tissue of female-to-male transsexuals. (16618941)
2006
14
High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. (15994752)
2005
15
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
16
Treatment of urethral stricture in a female-to-male transsexual with a tubulized flap from the labia minora. (15880292)
2005
17
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
18
Medical advances in transsexualism and the legal implications. (12605009)
2003
19
Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: effects of estrogenic treatment on bone metabolism of the male. (14515001)
2003
20
Masculinity, femininity, and transsexualism. (12462479)
2002
21
Sudden death by arrhythmogenic right ventricular dysplasia in a South American transsexual? (9717380)
1998
22
Homocystinuria and transsexualism. (8622374)
1996
23
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
24
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
25
Transsexualism. (2064661)
1991
26
Perceived parental rearing style, parental divorce and transsexualism: a controlled study. (2236370)
1990
27
Transsexualism and anatomic sex ratio reversal in Poland. (3265612)
1988
28
Gonadotropins and gonadal function in transsexualism and hypospadias. (3099183)
1986
29
A systems approach to child effeminacy and the prevention of adolescent transsexualism. (3782580)
1986
30
Transsexualism: ethical and legal aspects. (11658531)
1984
31
Psychological adjustment in transvestism and transsexualism. (7316917)
1981
32
Partnership in transsexualism. Part II. The nature of the partnership. (7247724)
1981
33
Gender identity conflicts in male transsexualism. (7362932)
1980
34
EEG abnormalities and transsexualism. (509010)
1979
35
Male transsexualism--a review of genital surgical reconstruction. (356612)
1978
36
Transsexualism and social attitudes. A case report. (1019364)
1976
37
Transsexualism in Vietnam. (1130982)
1975
38
Transsexualism in a fourteen-year-old male. (4653998)
1972
39
Family dynamics in male transsexualism. (5112328)
1971
40
Incidence and sex ratio of transsexualism in Sweden. (5565911)
1971
41
Male transsexualism: An endocrine study. (24179050)
1971
42
Transsexualism and surgical procedures. (4925941)
1971
43
A case of female transsexualism. (5514897)
1970
44
The desire for sexual transformation: a psychiatric evaluation of transsexualism. (5772927)
1969
45
Sex conversion operation in female transsexualism. (4179807)
1968
46
Transsexualism: considerations regarding sexual reassignment. (5726922)
1968
47
A case of female transsexualism. (6025196)
1967
48
Transsexualism: report of a case. (14427679)
1959
49
Homosexuality, transvestism and transsexualism; reflections on their etiology and differentiation. (13394762)
1957
50
Transsexualism and transvestism as psychosomatic and somatopsychic syndromes. (13148376)
1954

Variations for Transsexualism

About this section

Expression for genes affiliated with Transsexualism

About this section
Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

About this section

Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CYP17A1, CYP19A1
2
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.5CYP17A1, CYP19A1
3
Show member pathways
9.3ESR2, CYP19A1
49.3ESR2, CYP19A1
5
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2AR, CYP17A1
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1AR, SRD5A2
79.1AR, CYP19A1
8
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
9
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
10
Show member pathways
Nuclear Receptors37
9.0AR, ESR2
119.0ESR2, AR
12
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.0CYP17A1, CYP19A1, SRD5A2
13
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
14
Show member pathways
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
15
Show member pathways
8.2SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Compounds for genes affiliated with Transsexualism

About this section

Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1pregnanediol449.8CYP17A1, CYP21A2
2es 936619.6SRD5A2, SRD5A3
311b-Hydroxyprogesterone249.6CYP21A2, CYP17A1
4pcb 126449.5CYP17A1, CYP21A2, CYP19A1
5prochloraz449.4CYP19A1, ESR2
617-hydroxyprogesterone44 2410.4CYP19A1, CYP21A2, CYP17A1
7hpte44 2810.3ESR2, AR
8leuprolide acetate449.2CYP19A1, ESR2, CYP21A2
9clomiphene citrate449.2CYP19A1, CYP21A2, ESR2
10abiraterone acetate449.1AR, CYP17A1
11vinclozolin449.1AR, CYP19A1
12aminoglutethimide44 1110.0AR, CYP21A2, CYP19A1
13dutasteride44 1110.0AR, SRD5A2, CYP19A1
14nandrolone44 249.9AR, CYP19A1, ESR2
155alpha-androstane-3alpha,17beta-diol448.9AR, ESR2, CYP19A1
16fulvestrant44 50 28 1111.8AR, CYP19A1, ESR2
17levonorgestrel44 61 28 1111.8AR, CYP19A1, ESR2
18bicalutamide44 61 1110.8ESR2, CYP19A1, AR
194-tert-octylphenol448.7AR, ESR2
20ribonucleic acid448.7SRD5A2, CYP21A2, ESR2, CYP17A1
21progestins448.7AR, ESR2, CYP19A1
22ketoconazole44 28 24 1111.7CYP21A2, CYP19A1, CYP17A1, AR
23finasteride44 61 24 1111.7CYP19A1, AR, SRD5A3, SRD5A2
24dehydroepiandrosterone sulfate448.7CYP21A2, CYP17A1, AR, CYP19A1
25valine448.6CYP21A2, CYP17A1, SRD5A2, AR
26exemestane44 50 61 1111.5CYP17A1, ESR2, CYP19A1, AR
27bisphenol a448.5CYP19A1, CYP17A1, ESR2, AR
28letrozole44 50 61 1111.5CYP17A1, ESR2, CYP19A1, AR
29steroidal448.5AR, ESR2, CYP17A1, CYP19A1
30diethylstilbestrol44 28 1110.5AR, CYP17A1, CYP19A1, ESR2
31progestin448.5CYP17A1, CYP19A1, ESR2, AR
32estrone44 28 24 1111.5CYP19A1, AR, ESR2, CYP17A1
33chloramphenicol44 2 50 1111.4AR, ESR2, CYP21A2, CYP17A1
34tamoxifen44 50 28 1111.3CYP17A1, AR, ESR2, CYP19A1
35dhea448.1CYP21A2, AR, CYP19A1, CYP17A1, ESR2
36gnrh448.1CYP21A2, ESR2, AR, CYP17A1, CYP19A1
37genistein44 28 61 2 24 1113.0AR, CYP17A1, ESR2, CYP19A1, CYP21A2
38cycloheximide448.0CYP19A1, CYP21A2, ESR2, CYP17A1, AR
39vitamin d448.0AR, SRD5A2, ESR2, CYP19A1, CYP17A1
40dexamethasone44 50 28 1110.9AR, CYP17A1, ESR2, CYP21A2, CYP19A1
4117beta-hydroxysteroid447.6AR, CYP21A2, CYP19A1, CYP17A1, ESR2, SRD5A2
423beta-hydroxysteroid447.6AR, SRD5A2, ESR2, CYP21A2, CYP19A1, CYP17A1
43androstenedione44 248.6AR, SRD5A2, ESR2, CYP19A1, CYP17A1, CYP21A2
44dihydrotestosterone44 28 24 1110.6AR, CYP17A1, SRD5A2, CYP19A1, CYP21A2, ESR2
45estradiol44 24 119.6CYP17A1, CYP21A2, SRD5A2, CYP19A1, AR, ESR2
46progesterone44 28 61 24 1111.5AR, CYP21A2, CYP17A1, CYP19A1, SRD5A2, ESR2
47steroid447.5CYP19A1, CYP17A1, CYP21A2, ESR2, SRD5A2, AR
48arginine447.5CYP17A1, CYP19A1, AR, SRD5A2, ESR2, CYP21A2
49estrogen447.5CYP21A2, ESR2, CYP17A1, CYP19A1, AR, SRD5A2
50testosterone44 61 24 1110.2CYP19A1, ESR2, SRD5A2, CYP21A2, SRD5A3, AR

GO Terms for genes affiliated with Transsexualism

About this section

Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.2SRD5A3, CYP19A1, CYP17A1
2endoplasmic reticulum membraneGO:0057897.9SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:0067049.7CYP21A2, CYP17A1
2steroid biosynthetic processGO:0066949.5CYP19A1, CYP17A1
3androgen metabolic processGO:0082099.4CYP19A1, SRD5A2
4androgen biosynthetic processGO:0067029.4CYP17A1, SRD5A2, SRD5A3
5sterol metabolic processGO:0161259.3CYP21A2, CYP19A1, CYP17A1
6xenobiotic metabolic processGO:0068059.2CYP21A2, CYP19A1, CYP17A1
7sex differentiationGO:0075489.1CYP17A1, AR
8steroid metabolic processGO:0082028.4SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1
9small molecule metabolic processGO:0442818.3CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
10cell-cell signalingGO:0072678.2AR, SRD5A2, ESR2

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.7SRD5A3, SRD5A2
2cholestenone 5-alpha-reductase activityGO:0477519.7SRD5A3, SRD5A2
3steroid bindingGO:0054969.3ESR2, CYP21A2
4oxygen bindingGO:0198259.2CYP19A1, CYP17A1
5heme bindingGO:0200379.2CYP21A2, CYP19A1, CYP17A1
6iron ion bindingGO:0055069.1CYP17A1, CYP19A1, CYP21A2
7ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.0AR, ESR2

Products for genes affiliated with Transsexualism

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Transsexualism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet