Aliases & Classifications for Transsexualism

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Transsexualism, Aliases & Descriptions:

Name: Transsexualism 9 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:10919
ICD9CM27 302.50
SNOMED-CT55 191782007
ICD1025 F64.0

Summaries for Transsexualism

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Disease Ontology:9 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary: Transsexualism is related to osteoporosis and klinefelter's syndrome. An important gene associated with Transsexualism is SRD5A3 (steroid 5 alpha-reductase 3), and among its related pathways are Ovarian steroidogenesis and Estrone metabolism. The compounds pregnanediol and es 936 have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:63 Transsexualism is a feeling of identification with a gender inconsistent or not culturally associated... more...

Related Diseases for Transsexualism

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Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.0ESR2, CYP19A1
2klinefelter's syndrome29.9CYP19A1, CYP21A2, AR
3hypogonadism29.8CYP19A1, AR
4hyperandrogenism29.7AR, CYP21A2, CYP19A1, CYP17A1
5adenoma29.6ESR2, CYP21A2, CYP17A1
6polycystic ovary syndrome29.5CYP17A1, CYP19A1, CYP21A2, AR
7hypospadias29.5CYP17A1, CYP21A2, SRD5A2, AR
8infertility29.3CYP19A1, CYP21A2, ESR2, AR
9prostate cancer29.0CYP17A1, CYP19A1, ESR2, SRD5A2, AR
10transvestism10.5
11gender identity disorder10.3
12autoimmune polyendocrine syndrome type 110.2CYP17A1, CYP21A2
13conn's syndrome10.2CYP21A2, CYP17A1
14hyperaldosteronism10.2CYP17A1, CYP21A2
15alopecia10.2AR
16schizophrenia10.2
17prolactinoma10.2
18prostatitis10.2
19anovulation10.2CYP19A1, CYP21A2
20precocious puberty10.1CYP21A2, CYP19A1
21addison's disease10.1CYP21A2, CYP17A1
22cushing's syndrome10.1CYP21A2, CYP17A1
23ovarian cyst10.1CYP19A1, ESR2
24endometrial stromal sarcoma10.1ESR2, CYP19A1
25homocystinuria10.1
26fetishism10.1
27ovarian disease10.1
28li-fraumeni syndrome10.1ESR2, CYP19A1
29androgen insensitivity10.1SRD5A2, AR
30antley-bixler syndrome10.0CYP21A2, CYP19A1, CYP17A1
31endocrine gland cancer10.0CYP19A1, AR
32adrenal adenoma10.0CYP21A2, CYP19A1, CYP17A1
33complete androgen insensitivity syndrome10.0CYP19A1, AR
34congenital adrenal hyperplasia10.0CYP21A2, CYP19A1, CYP17A1
35androgen insensitivity, partial, with or without breast cancer10.0CYP19A1, AR
36leydig cell tumor10.0CYP17A1, CYP19A1, CYP21A2
37adrenocortical carcinoma10.0CYP17A1, CYP19A1, CYP21A2
38adrenal cortical adenoma10.0CYP21A2, CYP19A1, CYP17A1
39prostate disease10.0AR, CYP19A1
40sertoli cell tumor10.0CYP19A1, AR
41germ cell cancer10.0AR, ESR2
42cryptorchidism10.0AR, CYP19A1
43leiomyoma10.0ESR2, CYP19A1, CYP17A1
44breast ductal carcinoma10.0AR, ESR2
45systemic lupus erythematosus9.9
46obsessive-compulsive disorder9.9
47obesity9.9
48anorexia nervosa9.9
49hepatitis9.9
50hepatitis b9.9

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Symptoms for Transsexualism

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Drugs & Therapeutics for Transsexualism

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Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

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Anatomical Context for Transsexualism

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MalaCards organs/tissues related to Transsexualism:

31
Bone, Breast, Testes, Ovary, Prostate, Pituitary, Brain, Adipocyte, Thyroid, Cervix

Animal Models for Transsexualism or affiliated genes

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MGI Mouse Phenotypes related to Transsexualism:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5AR, ESR2, CYP19A1
2MP:00053797.7CYP19A1, ESR2, SRD5A2, AR
3MP:00053897.5AR, SRD5A2, ESR2, CYP19A1, CYP17A1

Publications for Transsexualism

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Articles related to Transsexualism:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. (25124466)
2014
2
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. (24680383)
2014
3
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. (23857518)
2014
4
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. (23809495)
2013
5
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. (23970664)
2013
6
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. (23897544)
2013
7
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
8
Karyotyping, is it worthwhile in transsexualism? (21114769)
2011
9
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. (19620824)
2010
10
Transsexualism--diagnostic and therapeutic aspects. (20806188)
2010
11
Transsexualism in Australia: a further statistic. (19227577)
2009
12
A common polymorphism of the SRD5A2 gene and transsexualism. (18000232)
2007
13
Effects of long-term androgen administration on breast tissue of female-to-male transsexuals. (16618941)
2006
14
High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. (15994752)
2005
15
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
16
Treatment of urethral stricture in a female-to-male transsexual with a tubulized flap from the labia minora. (15880292)
2005
17
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
18
Medical advances in transsexualism and the legal implications. (12605009)
2003
19
Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: effects of estrogenic treatment on bone metabolism of the male. (14515001)
2003
20
Masculinity, femininity, and transsexualism. (12462479)
2002
21
A psycho-endocrinological overview of transsexualism. (11580991)
2001
22
Sudden death by arrhythmogenic right ventricular dysplasia in a South American transsexual? (9717380)
1998
23
Homocystinuria and transsexualism. (8622374)
1996
24
Further insights into transsexualism. (8711070)
1996
25
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
26
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
27
Transsexualism. (2064661)
1991
28
Perceived parental rearing style, parental divorce and transsexualism: a controlled study. (2236370)
1990
29
Transsexualism and anatomic sex ratio reversal in Poland. (3265612)
1988
30
Gonadotropins and gonadal function in transsexualism and hypospadias. (3099183)
1986
31
A systems approach to child effeminacy and the prevention of adolescent transsexualism. (3782580)
1986
32
Transsexualism: ethical and legal aspects. (11658531)
1984
33
Psychological adjustment in transvestism and transsexualism. (7316917)
1981
34
Partnership in transsexualism. Part II. The nature of the partnership. (7247724)
1981
35
Gender identity conflicts in male transsexualism. (7362932)
1980
36
EEG abnormalities and transsexualism. (509010)
1979
37
Male transsexualism--a review of genital surgical reconstruction. (356612)
1978
38
Transsexualism and social attitudes. A case report. (1019364)
1976
39
Transsexualism in Vietnam. (1130982)
1975
40
Transsexualism in a fourteen-year-old male. (4653998)
1972
41
Family dynamics in male transsexualism. (5112328)
1971
42
Incidence and sex ratio of transsexualism in Sweden. (5565911)
1971
43
Male transsexualism: An endocrine study. (24179050)
1971
44
Transsexualism and surgical procedures. (4925941)
1971
45
The desire for sexual transformation: a psychiatric evaluation of transsexualism. (5772927)
1969
46
Sex conversion operation in female transsexualism. (4179807)
1968
47
Transsexualism: considerations regarding sexual reassignment. (5726922)
1968
48
A case of female transsexualism. (6025196)
1967
49
Homosexuality, transvestism and transsexualism; reflections on their etiology and differentiation. (13394762)
1957
50
Transsexualism and transvestism as psychosomatic and somatopsychic syndromes. (13148376)
1954

Variations for Transsexualism

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Expression for genes affiliated with Transsexualism

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Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

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Pathways related to Transsexualism according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CYP17A1, CYP19A1
2
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
9.5CYP17A1, CYP19A1
3
Show member pathways
9.3ESR2, CYP19A1
49.3ESR2, CYP19A1
5
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2AR, CYP17A1
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.1AR, SRD5A2
79.1AR, CYP19A1
8
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
9
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
10
Show member pathways
Nuclear Receptors36
9.0AR, ESR2
119.0ESR2, AR
12
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.0CYP17A1, CYP19A1, SRD5A2
13
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
14
Show member pathways
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
15
Show member pathways
8.2SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Compounds for genes affiliated with Transsexualism

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Compounds related to Transsexualism according to GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1pregnanediol439.8CYP17A1, CYP21A2
2es 936599.6SRD5A2, SRD5A3
311b-Hydroxyprogesterone249.6CYP21A2, CYP17A1
4pcb 126439.5CYP17A1, CYP21A2, CYP19A1
5prochloraz439.4CYP19A1, ESR2
617-hydroxyprogesterone43 2410.4CYP19A1, CYP21A2, CYP17A1
7hpte43 2810.3ESR2, AR
8leuprolide acetate439.2CYP19A1, ESR2, CYP21A2
9clomiphene citrate439.2CYP19A1, CYP21A2, ESR2
10abiraterone acetate439.1AR, CYP17A1
11vinclozolin439.1AR, CYP19A1
12aminoglutethimide43 1210.0AR, CYP21A2, CYP19A1
13dutasteride43 1210.0AR, SRD5A2, CYP19A1
14nandrolone43 249.9AR, CYP19A1, ESR2
155alpha-androstane-3alpha,17beta-diol438.9AR, ESR2, CYP19A1
16fulvestrant43 49 28 1211.8AR, CYP19A1, ESR2
17levonorgestrel43 59 28 1211.8AR, CYP19A1, ESR2
18bicalutamide43 59 1210.8ESR2, CYP19A1, AR
194-tert-octylphenol438.7AR, ESR2
20ribonucleic acid438.7SRD5A2, CYP21A2, ESR2, CYP17A1
21progestins438.7AR, ESR2, CYP19A1
22ketoconazole43 28 24 1211.7CYP21A2, CYP19A1, CYP17A1, AR
23finasteride43 59 24 1211.7CYP19A1, AR, SRD5A3, SRD5A2
24dehydroepiandrosterone sulfate438.7CYP21A2, CYP17A1, AR, CYP19A1
25valine438.6CYP21A2, CYP17A1, SRD5A2, AR
26exemestane43 49 59 1211.5CYP17A1, ESR2, CYP19A1, AR
27bisphenol a438.5CYP19A1, CYP17A1, ESR2, AR
28letrozole43 49 59 1211.5CYP17A1, ESR2, CYP19A1, AR
29steroidal438.5AR, ESR2, CYP17A1, CYP19A1
30diethylstilbestrol43 28 1210.5AR, CYP17A1, CYP19A1, ESR2
31progestin438.5CYP17A1, CYP19A1, ESR2, AR
32estrone43 28 24 1211.5CYP19A1, AR, ESR2, CYP17A1
33chloramphenicol43 2 49 1211.4AR, ESR2, CYP21A2, CYP17A1
34tamoxifen43 49 28 1211.3CYP17A1, AR, ESR2, CYP19A1
35dhea438.1CYP21A2, AR, CYP19A1, CYP17A1, ESR2
36gnrh438.1CYP21A2, ESR2, AR, CYP17A1, CYP19A1
37genistein43 28 59 2 24 1213.0AR, CYP17A1, ESR2, CYP19A1, CYP21A2
38cycloheximide438.0CYP19A1, CYP21A2, ESR2, CYP17A1, AR
39vitamin d438.0AR, SRD5A2, ESR2, CYP19A1, CYP17A1
40dexamethasone43 49 28 1210.9AR, CYP17A1, ESR2, CYP21A2, CYP19A1
4117beta-hydroxysteroid437.6AR, CYP21A2, CYP19A1, CYP17A1, ESR2, SRD5A2
423beta-hydroxysteroid437.6AR, SRD5A2, ESR2, CYP21A2, CYP19A1, CYP17A1
43androstenedione43 248.6AR, SRD5A2, ESR2, CYP19A1, CYP17A1, CYP21A2
44dihydrotestosterone43 28 24 1210.6AR, CYP17A1, SRD5A2, CYP19A1, CYP21A2, ESR2
45estradiol43 24 129.6CYP17A1, CYP21A2, SRD5A2, CYP19A1, AR, ESR2
46progesterone43 28 59 24 1211.5AR, CYP21A2, CYP17A1, CYP19A1, SRD5A2, ESR2
47steroid437.5CYP19A1, CYP17A1, CYP21A2, ESR2, SRD5A2, AR
48arginine437.5CYP17A1, CYP19A1, AR, SRD5A2, ESR2, CYP21A2
49estrogen437.5CYP21A2, ESR2, CYP17A1, CYP19A1, AR, SRD5A2
50testosterone43 59 24 1210.2CYP19A1, ESR2, SRD5A2, CYP21A2, SRD5A3, AR

GO Terms for genes affiliated with Transsexualism

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Cellular components related to Transsexualism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:00057839.2SRD5A3, CYP19A1, CYP17A1
2endoplasmic reticulum membraneGO:00057897.9SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00067049.7CYP21A2, CYP17A1
2steroid biosynthetic processGO:00066949.5CYP19A1, CYP17A1
3androgen metabolic processGO:00082099.4CYP19A1, SRD5A2
4androgen biosynthetic processGO:00067029.4CYP17A1, SRD5A2, SRD5A3
5sterol metabolic processGO:00161259.3CYP21A2, CYP19A1, CYP17A1
6xenobiotic metabolic processGO:00068059.2CYP21A2, CYP19A1, CYP17A1
7sex differentiationGO:00075489.1CYP17A1, AR
8steroid metabolic processGO:00082028.4SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1
9small molecule metabolic processGO:00442818.3CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
10cell-cell signalingGO:00072678.2AR, SRD5A2, ESR2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00038659.7SRD5A3, SRD5A2
2cholestenone 5-alpha-reductase activityGO:00477519.7SRD5A3, SRD5A2
3steroid bindingGO:00054969.3ESR2, CYP21A2
4oxygen bindingGO:00198259.2CYP19A1, CYP17A1
5heme bindingGO:00200379.2CYP21A2, CYP19A1, CYP17A1
6iron ion bindingGO:00055069.1CYP17A1, CYP19A1, CYP21A2
7ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.0AR, ESR2

Products for genes affiliated with Transsexualism

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Sources for Transsexualism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet