MCID: TRN007
MIFTS: 49

Transsexualism malady

Mental diseases category
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Summaries for Transsexualism

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards: Transsexualism is related to klinefelter's syndrome and hypogonadism. An important gene associated with Transsexualism is SRD5A3 (steroid 5 alpha-reductase 3), and among its related pathways are Ovarian steroidogenesis and Estrone metabolism. The compounds pregnanediol and es 936 have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:65 Transsexualism is when an individual identifies with a gender inconsistent or not culturally associated... more...

Aliases & Classifications for Transsexualism

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

transsexualism 8 10 62


External Ids:

Disease Ontology8 DOID:10919
ICD9CM27 302.50
SNOMED-CT58 191782007
ICD1025 F64.0

Related Diseases for Transsexualism

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17GeneCards, 18GeneDecks
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Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1klinefelter's syndrome30.1CYP21A2, AR, CYP19A1
2hypogonadism29.9CYP19A1, AR
3osteoporosis29.9ESR2, CYP19A1, CYP21A2
4insulin resistance29.9CYP17A1, CYP21A2, ESR2
5adenoma29.8ESR2, CYP17A1, CYP21A2
6hypospadias29.8CYP17A1, SRD5A2, AR, CYP21A2
7hyperandrogenism29.8AR, CYP21A2, CYP19A1, CYP17A1
8prostate cancer29.7CYP19A1, SRD5A2, AR, CYP17A1, ESR2
9transvestism10.5
10gender identity disorder10.3
11prostatitis10.2
12schizophrenia10.2
13homocystinuria10.1
14prolactinoma10.1
15fetishism10.1
16ovarian disease10.1
17venous thrombosis10.1
18autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1CYP21A2, CYP17A1
19conn's syndrome10.1CYP17A1, CYP21A2
20hyperaldosteronism10.0CYP17A1, CYP21A2
21alopecia10.0AR
22anovulation10.0CYP21A2, CYP19A1
23addison's disease10.0CYP21A2, CYP17A1
24precocious puberty10.0CYP19A1, CYP21A2
25cushing's syndrome10.0CYP21A2, CYP17A1
26ovarian cyst10.0ESR2, CYP19A1
27endometrial stromal sarcoma10.0ESR2, CYP19A1
28li-fraumeni syndrome10.0ESR2, CYP19A1
29osteoporosis, postmenopausal10.0ESR2, CYP19A1
30androgen insensitivity syndrome10.0AR, SRD5A2
31antley-bixler syndrome10.0CYP19A1, CYP17A1, CYP21A2
32endocrine gland cancer10.0CYP19A1, AR
33partial androgen insensitivity syndrome10.0AR, CYP19A1
34congenital adrenal hyperplasia10.0CYP17A1, CYP19A1, CYP21A2
35complete androgen insensitivity syndrome10.0AR, CYP19A1
36leydig cell tumor10.0CYP21A2, CYP19A1, CYP17A1
37adrenocortical carcinoma10.0CYP21A2, CYP19A1, CYP17A1
38short stature10.0CYP21A2, CYP19A1
39adrenal adenoma10.0CYP19A1, CYP21A2, CYP17A1
40prostate disease10.0AR, CYP19A1
41sertoli cell tumor10.0AR, CYP19A1
42germ cell cancer10.0ESR2, AR
43cryptorchidism10.0CYP19A1, AR
44leiomyoma10.0CYP19A1, ESR2, CYP17A1
45endometriosis10.0CYP17A1, CYP19A1, ESR2
46endometrial carcinoma10.0CYP17A1, CYP19A1, ESR2
47penis agenesis10.0SRD5A2, CYP17A1, AR
48graves' disease10.0ESR2, CYP21A2
49azoospermia10.0AR, ESR2, CYP21A2
50uterine fibroid9.9CYP19A1, ESR2, CYP21A2, CYP17A1

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Symptoms for Transsexualism

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Drugs & Therapeutics for Transsexualism

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

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Anatomical Context for Transsexualism

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33MalaCards
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MalaCards organs/tissues related to Transsexualism:

33
Bone, Breast, Testes, Prostate, Pituitary, Brain, Thyroid, Cervix, Adipocyte

Animal Models for Transsexualism or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Transsexualism:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5AR, ESR2, CYP19A1
2MP:00053797.7CYP19A1, ESR2, SRD5A2, AR
3MP:00053897.5AR, SRD5A2, ESR2, CYP19A1, CYP17A1

Publications for Transsexualism

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Sources:
52PubMed
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Articles related to Transsexualism:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. (23857518)
2014
2
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. (23809495)
2013
3
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. (23970664)
2013
4
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. (23897544)
2013
5
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
6
Karyotyping, is it worthwhile in transsexualism? (21114769)
2011
7
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. (19620824)
2010
8
Transsexualism--diagnostic and therapeutic aspects. (20806188)
2010
9
Transsexualism in Australia: a further statistic. (19227577)
2009
10
A common polymorphism of the SRD5A2 gene and transsexualism. (18000232)
2007
11
Effects of long-term androgen administration on breast tissue of female-to-male transsexuals. (16618941)
2006
12
High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. (15994752)
2005
13
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
14
Treatment of urethral stricture in a female-to-male transsexual with a tubulized flap from the labia minora. (15880292)
2005
15
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
16
Medical advances in transsexualism and the legal implications. (12605009)
2003
17
Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: effects of estrogenic treatment on bone metabolism of the male. (14515001)
2003
18
Masculinity, femininity, and transsexualism. (12462479)
2002
19
A psycho-endocrinological overview of transsexualism. (11580991)
2001
20
Sudden death by arrhythmogenic right ventricular dysplasia in a South American transsexual? (9717380)
1998
21
Homocystinuria and transsexualism. (8622374)
1996
22
Further insights into transsexualism. (8711070)
1996
23
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
24
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
25
Transsexualism. (2064661)
1991
26
Perceived parental rearing style, parental divorce and transsexualism: a controlled study. (2236370)
1990
27
Transsexualism and anatomic sex ratio reversal in Poland. (3265612)
1988
28
Gonadotropins and gonadal function in transsexualism and hypospadias. (3099183)
1986
29
A systems approach to child effeminacy and the prevention of adolescent transsexualism. (3782580)
1986
30
Transsexualism: ethical and legal aspects. (11658531)
1984
31
Psychological adjustment in transvestism and transsexualism. (7316917)
1981
32
Partnership in transsexualism. Part II. The nature of the partnership. (7247724)
1981
33
Gender identity conflicts in male transsexualism. (7362932)
1980
34
EEG abnormalities and transsexualism. (509010)
1979
35
Male transsexualism--a review of genital surgical reconstruction. (356612)
1978
36
Transsexualism and social attitudes. A case report. (1019364)
1976
37
Transsexualism in Vietnam. (1130982)
1975
38
Transsexualism in a fourteen-year-old male. (4653998)
1972
39
Family dynamics in male transsexualism. (5112328)
1971
40
Incidence and sex ratio of transsexualism in Sweden. (5565911)
1971
41
Male transsexualism: An endocrine study. (24179050)
1971
42
Transsexualism and surgical procedures. (4925941)
1971
43
A case of female transsexualism. (5514897)
1970
44
The desire for sexual transformation: a psychiatric evaluation of transsexualism. (5772927)
1969
45
Sex conversion operation in female transsexualism. (4179807)
1968
46
Transsexualism: considerations regarding sexual reassignment. (5726922)
1968
47
A case of female transsexualism. (6025196)
1967
48
Transsexualism: report of a case. (14427679)
1959
49
Homosexuality, transvestism and transsexualism; reflections on their etiology and differentiation. (13394762)
1957
50
Transsexualism and transvestism as psychosomatic and somatopsychic syndromes. (13148376)
1954

Variations for Transsexualism

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Expression for genes affiliated with Transsexualism

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems
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Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CYP17A1, CYP19A1
2
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.5CYP17A1, CYP19A1
3
Show member pathways
9.3ESR2, CYP19A1
49.3ESR2, CYP19A1
5
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2AR, CYP17A1
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1AR, SRD5A2
79.1AR, CYP19A1
8
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
9
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
10
Show member pathways
Nuclear Receptors38
9.0AR, ESR2
119.0ESR2, AR
12
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.0CYP17A1, CYP19A1, SRD5A2
13
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
14
Show member pathways
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
15
Show member pathways
8.2SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Compounds for genes affiliated with Transsexualism

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45Novoseek, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1pregnanediol459.8CYP17A1, CYP21A2
2es 936619.6SRD5A2, SRD5A3
311b-Hydroxyprogesterone249.6CYP21A2, CYP17A1
4pcb 126459.5CYP17A1, CYP21A2, CYP19A1
5prochloraz459.4CYP19A1, ESR2
617-hydroxyprogesterone45 2410.4CYP19A1, CYP21A2, CYP17A1
7hpte45 2910.3ESR2, AR
8leuprolide acetate459.2CYP19A1, ESR2, CYP21A2
9clomiphene citrate459.2CYP19A1, CYP21A2, ESR2
10abiraterone acetate459.1AR, CYP17A1
11vinclozolin459.1AR, CYP19A1
12aminoglutethimide45 1110.0AR, CYP21A2, CYP19A1
13dutasteride45 1110.0AR, SRD5A2, CYP19A1
14nandrolone45 249.9AR, CYP19A1, ESR2
155alpha-androstane-3alpha,17beta-diol458.9AR, ESR2, CYP19A1
16fulvestrant45 51 29 1111.8AR, CYP19A1, ESR2
17levonorgestrel45 61 29 1111.8AR, CYP19A1, ESR2
18bicalutamide45 61 1110.8ESR2, CYP19A1, AR
194-tert-octylphenol458.7AR, ESR2
20ribonucleic acid458.7SRD5A2, CYP21A2, ESR2, CYP17A1
21progestins458.7AR, ESR2, CYP19A1
22ketoconazole45 29 24 1111.7CYP21A2, CYP19A1, CYP17A1, AR
23finasteride45 61 24 1111.7CYP19A1, AR, SRD5A3, SRD5A2
24dehydroepiandrosterone sulfate458.7CYP21A2, CYP17A1, AR, CYP19A1
25valine458.6CYP21A2, CYP17A1, SRD5A2, AR
26exemestane45 51 61 1111.5CYP17A1, ESR2, CYP19A1, AR
27bisphenol a458.5CYP19A1, CYP17A1, ESR2, AR
28letrozole45 51 61 1111.5CYP17A1, ESR2, CYP19A1, AR
29steroidal458.5AR, ESR2, CYP17A1, CYP19A1
30diethylstilbestrol45 29 1110.5AR, CYP17A1, CYP19A1, ESR2
31progestin458.5CYP17A1, CYP19A1, ESR2, AR
32estrone45 29 24 1111.5CYP19A1, AR, ESR2, CYP17A1
33chloramphenicol45 3 51 1111.4AR, ESR2, CYP21A2, CYP17A1
34tamoxifen45 51 29 1111.3CYP17A1, AR, ESR2, CYP19A1
35dhea458.1CYP21A2, AR, CYP19A1, CYP17A1, ESR2
36gnrh458.1CYP21A2, ESR2, AR, CYP17A1, CYP19A1
37genistein45 29 61 3 24 1113.0AR, CYP17A1, ESR2, CYP19A1, CYP21A2
38cycloheximide458.0CYP19A1, CYP21A2, ESR2, CYP17A1, AR
39vitamin d458.0AR, SRD5A2, ESR2, CYP19A1, CYP17A1
40dexamethasone45 51 29 1110.9AR, CYP17A1, ESR2, CYP21A2, CYP19A1
4117beta-hydroxysteroid457.6AR, CYP21A2, CYP19A1, CYP17A1, ESR2, SRD5A2
423beta-hydroxysteroid457.6AR, SRD5A2, ESR2, CYP21A2, CYP19A1, CYP17A1
43androstenedione45 248.6AR, SRD5A2, ESR2, CYP19A1, CYP17A1, CYP21A2
44dihydrotestosterone45 29 24 1110.6AR, CYP17A1, SRD5A2, CYP19A1, CYP21A2, ESR2
45estradiol45 24 119.6CYP17A1, CYP21A2, SRD5A2, CYP19A1, AR, ESR2
46progesterone45 29 61 24 1111.5AR, CYP21A2, CYP17A1, CYP19A1, SRD5A2, ESR2
47steroid457.5CYP19A1, CYP17A1, CYP21A2, ESR2, SRD5A2, AR
48arginine457.5CYP17A1, CYP19A1, AR, SRD5A2, ESR2, CYP21A2
49estrogen457.5CYP21A2, ESR2, CYP17A1, CYP19A1, AR, SRD5A2
50testosterone45 61 24 1110.2CYP19A1, ESR2, SRD5A2, CYP21A2, SRD5A3, AR

GO Terms for genes affiliated with Transsexualism

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16Gene Ontology
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Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.2SRD5A3, CYP19A1, CYP17A1
2endoplasmic reticulum membraneGO:0057897.9SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:0067049.7CYP21A2, CYP17A1
2steroid biosynthetic processGO:0066949.5CYP19A1, CYP17A1
3androgen metabolic processGO:0082099.4CYP19A1, SRD5A2
4androgen biosynthetic processGO:0067029.4CYP17A1, SRD5A2, SRD5A3
5sterol metabolic processGO:0161259.3CYP21A2, CYP19A1, CYP17A1
6xenobiotic metabolic processGO:0068059.2CYP21A2, CYP19A1, CYP17A1
7sex differentiationGO:0075489.1CYP17A1, AR
8steroid metabolic processGO:0082028.4SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1
9small molecule metabolic processGO:0442818.3CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
10cell-cell signalingGO:0072678.2AR, SRD5A2, ESR2

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.7SRD5A3, SRD5A2
2cholestenone 5-alpha-reductase activityGO:0477519.7SRD5A3, SRD5A2
3steroid bindingGO:0054969.3ESR2, CYP21A2
4oxygen bindingGO:0198259.2CYP19A1, CYP17A1
5heme bindingGO:0200379.2CYP21A2, CYP19A1, CYP17A1
6iron ion bindingGO:0055069.1CYP17A1, CYP19A1, CYP21A2
7ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.0AR, ESR2

Products for genes affiliated with Transsexualism

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Sources for Transsexualism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet