MCID: TRN007
MIFTS: 41

Transsexualism malady

Categories: Mental diseases

Aliases & Classifications for Transsexualism

Aliases & Descriptions for Transsexualism:

Name: Transsexualism 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 35 302.50
SNOMED-CT 64 191782007
ICD10 33 F64.0
UMLS 69 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to ulceroglandular tularemia and malignant teratocarcinosarcoma. An important gene associated with Transsexualism is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Metabolism of steroid hormones and Androstenedione and testosterone biosynthesis and metabolism p.1. The drugs Cyproterone Acetate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related phenotypes are endocrine/exocrine gland and adipose tissue

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 ulceroglandular tularemia 10.2 AR ESR2
2 malignant teratocarcinosarcoma 10.2 AR ESR2
3 dystonia-parkinsonism, x-linked 10.2 AR CYP19A1
4 her2-receptor negative breast cancer 10.2 CYP19A1 ESR2
5 glioblastoma mesenchymal subtype 10.2 AR CYP19A1
6 carbuncle 10.2 AR ESR2
7 mature teratoma 10.2 AR ESR2
8 acute thyroiditis 10.2 CYP19A1 ESR2
9 perinatal jaundice due to hepatocellular damage 10.2 CYP19A1 ESR2
10 congenital articular rigidity 10.2 AR CYP19A1
11 esophagus sarcoma 10.1 AR CYP19A1
12 capillary disease 10.1 AR CYP19A1
13 gaucher's disease 10.1 AR CYP19A1
14 cardiomyopathy, dilated, 1v 10.1 CYP17A1 CYP19A1
15 transvestism 10.1
16 cervical spinal canal and spinal cord meningioma 10.1 CYP19A1 CYP21A2
17 dyt1 early-onset isolated dystonia 10.1 CYP17A1 CYP21A2
18 deafness, autosomal recessive 29 10.1 CYP17A1 CYP21A2
19 splenic infarction 10.1 AR ESR2
20 prostate cancer, hereditary, x-linked 1 10.1 AR ESR2
21 epithelial predominant pulmonary blastoma 10.1 CYP17A1 CYP21A2
22 clear cell acanthoma 10.0 CYP17A1 CYP21A2
23 avoidant personality disorder 10.0 AR CYP19A1 ESR2
24 microphthalmia, syndromic 9 10.0 CYP17A1 CYP21A2
25 intraventricular meningioma 10.0 AR SRD5A2
26 tick-borne encephalitis 10.0 CYP17A1 CYP21A2
27 benign perivascular tumor 10.0 AR CYP19A1 ESR2
28 jackson-weiss syndrome 10.0 CYP17A1 CYP21A2
29 exocervical carcinoma 10.0 AR CYP17A1 ESR2
30 adult medulloblastoma 10.0 AR CYP17A1 ESR2
31 bardet-biedl syndrome 10.0 AR CYP17A1 ESR2
32 ameloblastoma 10.0 CYP17A1 CYP21A2
33 panuveitis 10.0 CYP17A1 CYP21A2
34 deafness, autosomal recessive 74 10.0 CYP17A1 CYP19A1 ESR2
35 childhood optic tract astrocytoma 10.0 CYP17A1 CYP21A2
36 second-degree atrioventricular block 10.0 CYP17A1 CYP21A2
37 loeffler endocarditis 10.0 CYP17A1 CYP21A2
38 hypermobility syndrome 9.9 CYP17A1 CYP21A2
39 gender identity disorder 9.9
40 bent bone dysplasia syndrome 9.9 CYP17A1 CYP19A1 CYP21A2
41 epidemic typhus 9.9 CYP17A1 CYP19A1 CYP21A2
42 liver sarcoma 9.9 CYP17A1 CYP19A1 CYP21A2
43 spondylolysis 9.9 CYP19A1 ESR2
44 pelvic muscle wasting 9.9 CYP17A1 CYP19A1 CYP21A2
45 glioma susceptibility 1 9.9 CYP17A1 CYP19A1 CYP21A2
46 primary biliary cirrhosis 9.9 CYP17A1 CYP19A1 CYP21A2
47 hypospadias 1, x-linked 9.9 AR CYP19A1 SRD5A2
48 skin hemangioma 9.9 AR CYP19A1 SRD5A2
49 periodic fever, aphthous stomatitis, pharyngitis and adenitis 9.9 AR CYP17A1 SRD5A2
50 benign essential hypertension 9.9 AR CYP17A1 SRD5A2

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.77 RPGRIP1L SRD5A2 AR CYP19A1 ESR2
2 adipose tissue MP:0005375 9.71 AR CYP19A1 ESR2 RPGRIP1L
3 limbs/digits/tail MP:0005371 9.62 AR CYP17A1 ESR2 RPGRIP1L
4 liver/biliary system MP:0005370 9.56 AR CYP19A1 ESR2 RPGRIP1L
5 renal/urinary system MP:0005367 9.46 AR CYP19A1 ESR2 RPGRIP1L
6 reproductive system MP:0005389 9.35 AR CYP17A1 CYP19A1 ESR2 SRD5A2
7 skeleton MP:0005390 9.02 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757 53477783
3
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
4
Testolactone Approved Phase 4 968-93-4 13769
5
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
6 5-alpha Reductase Inhibitors Phase 4,Phase 3
7 Androgen Antagonists Phase 4
8 Androgens Phase 4,Phase 3
9 Antineoplastic Agents, Hormonal Phase 4,Phase 3
10 Contraceptive Agents Phase 4
11 Contraceptive Agents, Male Phase 4
12 Contraceptives, Oral Phase 4
13
Cyproterone Phase 4 2098-66-0 5284537
14 Estradiol 17 beta-cypionate Phase 4,Phase 3
15 Estradiol 3-benzoate Phase 4,Phase 3
16 Estradiol valerate Phase 4,Phase 3 979-32-8
17 Estrogens Phase 4,Phase 3
18 Hormone Antagonists Phase 4,Phase 3
19 Hormones Phase 4,Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
21 lynestrenol Phase 4
22 Neurotransmitter Agents Phase 4
23 Polyestradiol phosphate Phase 4,Phase 3
24
Serotonin Phase 4 50-67-9 5202
25 Serotonin Agents Phase 4
26 Steroid Synthesis Inhibitors Phase 4,Phase 3
27 Testosterone 17 beta-cypionate Phase 4,Phase 3
28
Testosterone enanthate Phase 4,Phase 3 315-37-7 9416
29 Testosterone undecanoate Phase 4,Phase 3
30
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
31
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
32
Dihydrotestosterone Illicit Phase 3 521-18-6 10635
33 Anabolic Agents Phase 3
34 Aromatase Inhibitors Phase 3
35 Estrogen Antagonists Phase 3
36
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
37 Cortisol succinate
38 Hydrocortisone 17-butyrate 21-propionate
39 Hydrocortisone acetate
40 vitamin d
41 Vitamins

Interventional clinical trials:


id Name Status NCT ID Phase
1 Sex Steroids and the Serotonin Transporter Completed NCT01065220 Phase 4
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3
3 A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism Completed NCT00435513 Early Phase 1
4 First Australian National Trans Mental Health Study Completed NCT02119377
5 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
6 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
7 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
8 A European Network for the Investigation of Gender Incongruence Recruiting NCT01072825

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

39
Bone, Breast, Testes, Brain, Prostate, Ovary, Pituitary

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 335)
id Title Authors Year
1
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. ( 27649696 )
2016
2
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. ( 27817755 )
2016
3
A Review of the Status of Brain Structure Research in Transsexualism. ( 27255307 )
2016
4
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. ( 27578416 )
2016
5
The transsexual brain - A review of findings on the neural basis of transsexualism. ( 26429593 )
2015
6
Systematic review and meta-analysis of prevalence studies in transsexualism. ( 26021270 )
2015
7
AntimA1llerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy. ( 25772768 )
2015
8
Sociodemographic Study of Danish Individuals Diagnosed with Transsexualism. ( 26185676 )
2015
9
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. ( 23857518 )
2014
10
Bilateral Non-arteritic Ischemic Optic Neuropathy in a Transsexual Woman Using Excessive Estrogen Dosage. ( 24057212 )
2014
11
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. ( 25124466 )
2014
12
Treatment of anorexia nervosa in the context of transsexuality: A case report. ( 24323528 )
2014
13
Diagnosis of prolactinoma in two male-to-female transsexual subjects following high-dose cross-sex hormone therapy. ( 25059808 )
2014
14
Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. ( 24134805 )
2014
15
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. ( 24680383 )
2014
16
Challenges in the diagnosis and treatment of transsexualism in contemporary China. ( 25114481 )
2014
17
Hypogonadism in a male-to-female transsexual with super obesity. ( 22783836 )
2013
18
Hysterectomy and bilateral adnexectomy by laparoscopic single port access for female to male transsexualism. ( 23433319 )
2013
19
Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review. ( 23916699 )
2013
20
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. ( 23809495 )
2013
21
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. ( 23897544 )
2013
22
More evidence that societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 23377823 )
2013
23
The (CA)n Polymorphism of ERI^ Gene is Associated with FtM Transsexualism. ( 24274329 )
2013
24
The "Auto" (Self) in Autogynephilic Transsexualism Men Trapped in Men's Bodies: Narratives of Autogynephilic Transsexualism. By Anne A. Lawrence. New York, NY: Springer, 2013, 242 pages. Cloth, $129.00. ( 24171550 )
2013
25
Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. ( 24329588 )
2013
26
Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual. ( 23022362 )
2013
27
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. ( 23970664 )
2013
28
On the quest for a biomechanism of transsexualism: is there a role for BDNF? ( 24070909 )
2013
29
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
30
Increased Cortical Thickness in Male-to-Female Transsexualism. ( 23724358 )
2012
31
Glottoplasty for male-to-female transsexualism: voice results. ( 20171832 )
2011
32
New MRI studies support the Blanchard typology of male-to-female transsexualism. ( 21739338 )
2011
33
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? ( 21691959 )
2011
34
Karyotyping, is it worthwhile in transsexualism? ( 21114769 )
2011
35
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. ( 21074005 )
2011
36
Human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in Argentina. ( 21511521 )
2011
37
Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. ( 21477021 )
2011
38
Societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 19067152 )
2010
39
Transsexualism - attitudes in general practice. ( 20372674 )
2010
40
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. ( 19620824 )
2010
41
Vaginal carcinoma in a female-to-male transsexual. ( 20102482 )
2010
42
Prolactinoma induced by estrogen and cyproterone acetate in a male-to-female transsexual. ( 20227072 )
2010
43
Transsexualism--diagnostic and therapeutic aspects. ( 20806188 )
2010
44
Transsexualism. ( 20642030 )
2010
45
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. ( 21078006 )
2010
46
Incidence of thrombophilia and venous thrombosis in transsexuals under cross-sex hormone therapy. ( 19200981 )
2010
47
Emphysematous Pyelonephritis in a non-diabetic post-operative Transsexual patient. ( 21597566 )
2010
48
Male-to-female transsexualism: technique, results and 3-year follow-up in 50 patients. ( 20389165 )
2010
49
Unilateral hypoplastic breast in a male-to-female transsexual with Poland syndrome after gender reassignment--reconstructive considerations. ( 18639510 )
2009
50
Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: results of a pilot study. ( 19497984 )
2009

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Cellular components related to Transsexualism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 8.92 CYP17A1 CYP19A1 CYP21A2 SRD5A2

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.81 CYP17A1 CYP19A1 CYP21A2 SRD5A2
2 cell-cell signaling GO:0007267 9.7 AR ESR2 SRD5A2
3 steroid metabolic process GO:0008202 9.63 CYP17A1 CYP21A2 SRD5A2
4 steroid hormone mediated signaling pathway GO:0043401 9.54 AR ESR2
5 androgen metabolic process GO:0008209 9.49 CYP19A1 SRD5A2
6 androgen biosynthetic process GO:0006702 9.48 CYP17A1 SRD5A2
7 progesterone metabolic process GO:0042448 9.43 CYP17A1 SRD5A2
8 glucocorticoid biosynthetic process GO:0006704 9.4 CYP17A1 CYP21A2
9 prostate gland growth GO:0060736 9.37 AR CYP19A1
10 sterol metabolic process GO:0016125 9.33 CYP17A1 CYP19A1 CYP21A2
11 testosterone biosynthetic process GO:0061370 9.32 CYP19A1 SRD5A2
12 female genitalia development GO:0030540 9.26 CYP19A1 SRD5A2
13 sex differentiation GO:0007548 9.13 AR CYP17A1 SRD5A2
14 steroid biosynthetic process GO:0006694 8.92 CYP17A1 CYP19A1 CYP21A2 SRD5A2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 CYP17A1 CYP19A1 CYP21A2 SRD5A2
2 lipid binding GO:0008289 9.58 AR CYP21A2 ESR2
3 iron ion binding GO:0005506 9.5 CYP17A1 CYP19A1 CYP21A2
4 steroid hormone receptor activity GO:0003707 9.48 AR ESR2
5 oxygen binding GO:0019825 9.46 CYP17A1 CYP19A1
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.43 AR ESR2
7 heme binding GO:0020037 9.43 CYP17A1 CYP19A1 CYP21A2
8 steroid hydroxylase activity GO:0008395 9.16 CYP19A1 CYP21A2
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP17A1 CYP19A1 CYP21A2
10 steroid binding GO:0005496 8.8 AR CYP21A2 ESR2

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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