MCID: TRN007
MIFTS: 53

Transsexualism malady

Neuronal diseases category

Summaries for Transsexualism

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards: Transsexualism is related to prostatitis and schizophrenia. An important gene associated with Transsexualism is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Mineralocorticoid biosynthesis and Osteoblast Signaling. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 Transsexualism is when an individual identifies with a gender inconsistent or not culturally associated... more...

Aliases & Classifications for Transsexualism

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

transsexualism 8 10 60


External Ids:

Disease Ontology8 DOID:10919
ICD9CM27 302.50
SNOMED-CT56 191782007
ICD1025 F64.0

Related Diseases for Transsexualism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.2KLK3
2schizophrenia30.1ESR2, PRL
3ovarian disease30.0SHBG, PRL, GNRH1
4prolactinoma30.0ESR2, PRL, GNRH1
5klinefelter's syndrome30.0CYP21A2, CYP19A1, SHBG, PRL, AR, GNRH1
6hepatitis29.8SERPINA7
7systemic lupus erythematosus29.8PRL
8hepatitis c29.8LPL
9hypoactive sexual desire disorder29.8SHBG
10thyroiditis29.8SERPINA7, CALCA
11prostate cancer29.8AR, KLK3
12anorexia nervosa29.8SHBG, PRL, TNFRSF11B, LSL
13hypospadias29.8SRD5A2, CYP21A2, CYP17A1, AR
14sexual disorder29.8SHBG, PRL, GNRH1, KLK3
15pituitary adenoma29.8ESR2, SERPINA7, PRL, GNRH1
16obesity29.8CYP21A2, LIPC, SHBG, LPL, AR, LSL
17adenoma29.8ESR2, CYP21A2, CYP17A1, SHBG, PRL, GNRH1
18hyperandrogenism29.8CYP21A2, CYP17A1, CYP19A1, SHBG, PRL, AR
19infertility29.8ESR2, CYP21A2, CYP19A1, SHBG, PRL, AR
20osteoporosis29.8ESR2, CYP21A2, CYP19A1, SHBG, TNFRSF11B, TNFSF11
21hypogonadism29.8CYP19A1, SHBG, PRL, AR, GNRH1, LSL
22transvestism10.5
23gender identity disorder10.2
24homocystinuria10.0
25fetishism10.0
26acne10.0SHBG
27thyrotoxicosis10.0SERPINA7
28psoriasis10.0KLK6
29acute myocardial infarction10.0TNFSF11
30osteonecrosis10.0BGLAP
31periodontitis10.0TNFRSF11B
32bulimia nervosa10.0LSL
33fibrous dysplasia10.0BGLAP
34panhypopituitarism10.0PRL
35metabolic acidosis10.0BGLAP
36pancreatitis10.0LPL
37germinoma10.0CYP21A2
38diabetic ketoacidosis10.0LSL
39diabetes insipidus10.0PRL
40sarcoma10.0AR
41aromatase deficiency10.0CYP19A1
42root resorption10.0TNFRSF11B
43nephrotic syndrome10.0LPL
44cholestasis10.0LIPC
45multiple sclerosis10.0LSL
46congenital hypothyroidism10.0SERPINA7, CYP21A2
47migraine10.0CALCA
48arteriosclerosis10.0LPL
49abetalipoproteinemia10.0LPL
50mccune albright syndrome10.0GNRH1

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Clinical Features for Transsexualism

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Drugs & Therapeutics for Transsexualism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Transsexualism

Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Search CenterWatch for Transsexualism

Genetic Tests for Transsexualism

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Anatomical Context for Transsexualism

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Sources:
32MalaCards
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MalaCards organs/tissues related to Transsexualism:

32
Bone, Breast, Testes, Prostate, Ovary, Pituitary, Thyroid, Adipocyte, Brain, Cervix

Animal Models for Transsexualism or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Transsexualism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9ESR2, SRD5A2, LIPC
2MP:00053899.8SRD5A2, LIPC, PRL, GNRH1
3MP:00107719.4CALCA, GNRH1, TNFSF11, AR, LPL
4MP:00053709.2ESR2, CYP19A1, PRL, LPL, AR, GNRH1
5MP:00053909.0GNRH1, TNFSF11, TNFRSF11B, AR, CYP19A1, ESR2
6MP:00053768.3CALCA, GNRH1, TNFSF11, AR, LPL, PRL

Publications for Transsexualism

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Sources:
50PubMed
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Articles related to Transsexualism:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Treatment of anorexia nervosa in the context of transsexuality: A case report. (24323528)
2014
2
Increased Cortical Thickness in Male-to-Female Transsexualism. (23724358)
2012
3
Emphysematous Pyelonephritis in a non-diabetic post-operative Transsexual patient. (21597566)
2010
4
Societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. (19067152)
2010
5
Transsexualism in Australia: a further statistic. (19227577)
2009
6
Twins and transsexualism: an update and a preview; research reviews: conjoined twins, angiographic lesions, single versus double embryo transfer; headlines: school placement legislation, Junior Taekwondo Olympics, prosthetic ears, murder victim. (18179403)
2007
7
Effects of long-term androgen administration on breast tissue of female-to-male transsexuals. (16618941)
2006
8
Male-to-female transsexualism: laparoscopic pelvic floor repair of prolapsed neovagina. (16704484)
2006
9
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
10
Sex steroid-related genes and male-to-female transsexualism. (15854782)
2005
11
Testosterone increases bone mineral density in female-to-male transsexuals: a case series of 15 subjects. (15521957)
2004
12
Mycobacterium abscessus cellulitis and multifocal abscesses of the breasts in a transsexual from illicit intramammary injections of silicone. (14988690)
2004
13
Sex chromosome aberrations and transsexualism. (12620457)
2003
14
A psycho-endocrinological overview of transsexualism. (11580991)
2001
15
Male-to-female transsexualism: a technique, results and long-term follow-up in 66 patients. (11564029)
2001
16
Transsexualism/gender identity disorder. (12120964)
2001
17
Transsexualism: a review of etiology, diagnosis and treatment. (10340231)
1999
18
Treatment; transsexualism; equal protection; deliberate indifference: Farmer v. Hawk. (11645061)
1998
19
Transsexualism and osteoporosis. (9792472)
1998
20
Further insights into transsexualism. (8711070)
1996
21
Transsexualism in Portugal: the legal framework and procedure, and its consequences for transsexuals. (8918089)
1996
22
Transsexualism and sex-related differences in hemispheric asymmetry. (8317258)
1993
23
Deoxyribonucleic acid histogram of testes in primary transsexualism. (8261307)
1993
24
Demanding subjectivity: transsexualism, medicine, and the technologies of gender. (11612877)
1992
25
Transsexualism and anatomic sex ratio reversal in Poland. (3265612)
1988
26
A nonspecific disturbance of the gonadostat in women with transsexualism and isolated hypergonadotropism in the male-to-female disturbance of gender identity. (3091382)
1986
27
Gender dysphoria, gender reorientation, and the clinical management of transsexualism. (4008715)
1985
28
Transsexualism: ethical and legal aspects. (11658531)
1984
29
Female-to-male transsexualism and sex roles: self and spouse ratings on the PAQ. (6712462)
1984
30
Transsexualism: a clinical approach to gender dysphoria. (6759840)
1982
31
Transsexualism. (7335594)
1981
32
The role of grandmothers in transsexualism. (7361945)
1980
33
Transsexualism: a standardized psychosocial rating format for the evaluation of results of sex reassignment surgery. (7396697)
1980
34
Male transsexualism. (474652)
1979
35
Gonadal lesions in transsexualism. (760913)
1979
36
Australian Transsexualism Committee. (318473)
1979
37
Autocastration in transsexualism. (420339)
1979
38
Parental relationships during childhood in homosexuality, transvestism and transsexualism. (278599)
1978
39
Male transsexualism in Singapore: a description of 56 cases. (922268)
1977
40
A typology of transsexualism: gender identity theory and data. (1008701)
1976
41
Transsexualism. (4486125)
1973
42
Transsexualism. (4588072)
1973
43
Transsexualism in a fourteen-year-old male. (4653998)
1972
44
A psychoanalytic study of the desire for sexual transformation ('transsexualism'): the plaster-of-paris man. (5503634)
1970
45
Treatment of transsexualism. (5469117)
1970
46
Investigations on a case of male transsexualism. (5404502)
1969
47
Transsexualism: considerations regarding sexual reassignment. (5726922)
1968
48
MALE PSYCHOSEXUAL INVERSION: TRANSSEXUALISM: A REVIEW OF 100 CASES. (14314763)
1965
49
Transsexualism: report of a case. (14427679)
1959
50
Transsexualism and transvestism as psychosomatic and somatopsychic syndromes. (13148376)
1954

Genetic Variations for Transsexualism

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Expression for genes affiliated with Transsexualism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CYP21A2, CYP17A1
210.1TNFRSF11B, TNFSF11
3
Hide members
10.1ESR2, CYP19A1
4
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10.0SRD5A2, SRD5A3, CYP17A1
5
Hide members
10.0CYP19A1, CYP17A1, CYP21A2
610.0CYP21A2, CYP17A1, CYP19A1
7
Transcription Androgen Receptor nuclear signaling
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10.0SRD5A2, AR, KLK3
89.9GNRH1, AR, SHBG
9
Development Prolactin receptor signaling
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9.7ESR2, CYP17A1, PRL, TNFSF11
10
Hide members
9.7CYP19A1, CYP17A1, CYP21A2, SRD5A3, SRD5A2
11
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.2CYP19A1, AR, TNFRSF11B, TNFSF11, CALCA, BGLAP

Compounds for genes affiliated with Transsexualism

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 228)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3KLK3, LIPC, SERPINA7
2goserelin44 28 1112.1LSL, GNRH1
3finasteride44 59 11 2412.8KLK3, AR, SHBG, CYP19A1, SRD5A3, SRD5A2
4bisphenol a449.7CYP19A1, AR, CYP17A1, SERPINA7, LPL, ESR2
5levonorgestrel44 59 28 1112.7PRL, SHBG, ESR2, CYP19A1, SERPINA7, AR
6ibandronate44 1110.7BGLAP, CALCA, TNFRSF11B, CYP19A1, TNFSF11
7spironolactone49 44 59 28 1113.7GNRH1, AR, SHBG, CYP21A2, SERPINA7, KLK3
817-hydroxyprogesterone44 2410.7GNRH1, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
9clomiphene citrate449.7SHBG, ESR2, CYP21A2, CYP19A1, PRL, GNRH1
10leuprolide44 59 28 1112.6AR, PRL, LSL, GNRH1, KLK3
11exemestane49 44 59 1112.6ESR2, CYP17A1, CYP19A1, SHBG, AR, BGLAP
12deoxypyridinoline449.6BGLAP, TNFRSF11B, TNFSF11, LSL, CALCA
13danazol44 11 2411.6GNRH1, AR, PRL, SHBG, LIPC, CYP19A1
14epinephrine44 11 2411.6CYP21A2, SHBG, PRL, LPL, LSL, CALCA
15leuprolide acetate449.6KLK3, GNRH1, SHBG, CYP19A1, CYP21A2, ESR2
163beta-hydroxysteroid449.5AR, CYP17A1, SRD5A2, CYP21A2, ESR2, CYP19A1
17flutamide44 59 1111.5CYP19A1, KLK3, GNRH1, TNFRSF11B, PRL, SHBG
1817beta-hydroxysteroid449.5CYP17A1, CYP21A2, SRD5A2, ESR2, CYP19A1, AR
19ketoconazole44 28 11 2412.5CYP21A2, CYP17A1, CYP19A1, SHBG, KLK3, AR
20diethylstilbestrol44 28 1111.5ESR2, CYP17A1, CYP19A1, SHBG, AR, GNRH1
21toremifene44 1110.5SHBG, ESR2, PRL, GNRH1, CYP19A1
22cyproteroneacetate449.5CYP19A1, SHBG, PRL, AR, GNRH1, BGLAP
23acth449.4PRL, LIPC, CYP17A1, CYP21A2, GNRH1, LSL
2425-hydroxyvitamin d449.4CYP19A1, SHBG, TNFRSF11B, TNFSF11, BGLAP, CALCA
25tibolone449.4LSL, GNRH1, CALCA, BGLAP, SHBG, CYP19A1
26progestin449.4GNRH1, AR, ESR2, PRL, SHBG, CYP19A1
27zoledronic acid449.4KLK3, BGLAP, CALCA, GNRH1, TNFSF11, CYP19A1
28progestins449.3GNRH1, KLK3, ESR2, CYP19A1, LIPC, SHBG
29buserelin44 28 1111.3KLK3, CYP19A1, PRL, GNRH1, CALCA
30corticosterone44 59 2411.2PRL, CALCA, CYP21A2, SERPINA7, BGLAP, LSL
31tamoxifen44 49 28 1112.2LSL, GNRH1, AR, LPL, CYP19A1, CYP17A1
32dehydroepiandrosterone sulfate449.2AR, PRL, SHBG, CYP19A1, CYP17A1, CYP21A2
33calcitriol44 59 11 2412.1CALCA, TNFSF11, BGLAP, LPL, AR, KLK3
34risedronate44 59 49 28 1113.1CALCA, CYP19A1, TNFRSF11B, TNFSF11, BGLAP
35gnrh449.1CYP21A2, CYP19A1, SHBG, AR, GNRH1, BGLAP
36hydrocortisone44 2 59 1112.0TNFRSF11B, PRL, SHBG, CYP19A1, CYP21A2, LSL
37dexamethasone44 49 28 1111.9LPL, SHBG, CYP17A1, CYP21A2, AR, TNFRSF11B
38androstenedione44 249.9AR, GNRH1, LSL, PRL, SHBG, ESR2
39estradiol44 11 2410.9PRL, KLK3, ESR2, GNRH1, SHBG, LIPC
40genistein44 28 59 2 11 2413.8CYP17A1, CYP19A1, ESR2, CYP21A2, LPL, TNFRSF11B
41dhea448.8SHBG, PRL, ESR2, CYP21A2, CYP17A1, CYP19A1
42raloxifene44 28 49 1111.8TNFRSF11B, SHBG, CYP19A1, SERPINA7, ESR2, TNFSF11
43estrone44 28 11 2411.6AR, GNRH1, LSL, BGLAP, ESR2, SERPINA7
44progesterone44 59 28 11 2412.6SRD5A2, PRL, LSL, GNRH1, CYP17A1, ESR2
45vitamin d448.6CYP19A1, CYP17A1, SRD5A2, ESR2, SHBG, KLK3
46thyroxine44 249.4SERPINA7, CYP21A2, KLK3, BGLAP, CALCA, LSL
47dihydrotestosterone44 28 11 2411.4CYP21A2, SRD5A2, ESR2, CYP17A1, CYP19A1, SHBG
48arginine448.2ESR2, SHBG, SERPINA7, LIPC, CYP19A1, CYP17A1
49steroid447.8LSL, GNRH1, TNFSF11, TNFRSF11B, AR, PRL
50testosterone44 59 11 2410.2KLK3, BGLAP, CALCA, LSL, GNRH1, TNFSF11

GO Terms for genes affiliated with Transsexualism

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16Gene Ontology
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Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8CALCA, GNRH1, TNFSF11, TNFRSF11B, LPL, LIPC
2extracellular regionGO:0055767.7ESR2, KLK6, KLK3, BGLAP, CALCA, GNRH1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.3CYP17A1, SRD5A3, SRD5A2
2prostate gland growthGO:06073610.2CYP19A1, AR
3very-low-density lipoprotein particle remodelingGO:03437210.2LIPC, LPL
4glucocorticoid biosynthetic processGO:00670410.2CYP17A1, CYP21A2
5sterol metabolic processGO:01612510.2CYP21A2, CYP17A1, CYP19A1
6ovulation cycleGO:04269810.1GNRH1, PRL
7negative regulation of bone resorptionGO:04577910.0TNFRSF11B, CALCA
8steroid metabolic processGO:0082029.9SRD5A2, SRD5A3, CYP21A2, CYP17A1, CYP19A1
9prostate gland epithelium morphogenesisGO:0607409.8ESR2, AR
10response to ethanolGO:0454719.7PRL, GNRH1, BGLAP
11cell-cell signalingGO:0072679.6CALCA, GNRH1, AR, SRD5A2, ESR2
12response to drugGO:0424939.6BGLAP, TNFRSF11B, LPL, PRL, CYP17A1, SERPINA7

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:00386510.3SRD5A2, SRD5A3
2cholestenone 5-alpha-reductase activityGO:04775110.2SRD5A2, SRD5A3
3androgen bindingGO:00549710.0AR, SHBG
4hormone activityGO:0051799.8PRL, GNRH1, CALCA
5phospholipase activityGO:0046209.7LIPC, LPL

Products for genes affiliated with Transsexualism

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  • Antibodies
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Sources for Transsexualism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet