MCID: TRN007
MIFTS: 49

Transsexualism malady

Mental diseases category

Summaries for Transsexualism

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards: Transsexualism is related to klinefelter's syndrome and hypogonadism. An important gene associated with Transsexualism is SRD5A3 (steroid 5 alpha-reductase 3), and among its related pathways are Ovarian steroidogenesis and Estrone metabolism. The compounds pregnanediol and es 936 have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and testes, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:66 Transsexualism is when an individual identifies with a gender inconsistent or not culturally associated... more...

Aliases & Classifications for Transsexualism

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

transsexualism 9 11 63


External Ids:

Disease Ontology9 DOID:10919
ICD9CM28 302.50
SNOMED-CT59 191782007
ICD1026 F64.0

Related Diseases for Transsexualism

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Transsexualism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1klinefelter's syndrome30.1CYP21A2, AR, CYP19A1
2hypogonadism29.9CYP19A1, AR
3osteoporosis29.9ESR2, CYP19A1, CYP21A2
4insulin resistance29.9CYP17A1, CYP21A2, ESR2
5adenoma29.8ESR2, CYP17A1, CYP21A2
6hypospadias29.8CYP17A1, SRD5A2, AR, CYP21A2
7hyperandrogenism29.8AR, CYP21A2, CYP19A1, CYP17A1
8prostate cancer29.7CYP19A1, SRD5A2, AR, CYP17A1, ESR2
9transvestism10.5
10gender identity disorder10.3
11prostatitis10.2
12schizophrenia10.2
13homocystinuria10.1
14prolactinoma10.1
15fetishism10.1
16ovarian disease10.1
17venous thrombosis10.1
18autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia10.1CYP21A2, CYP17A1
19conn's syndrome10.1CYP17A1, CYP21A2
20hyperaldosteronism10.0CYP17A1, CYP21A2
21alopecia10.0AR
22anovulation10.0CYP21A2, CYP19A1
23addison's disease10.0CYP21A2, CYP17A1
24precocious puberty10.0CYP19A1, CYP21A2
25cushing's syndrome10.0CYP21A2, CYP17A1
26ovarian cyst10.0ESR2, CYP19A1
27endometrial stromal sarcoma10.0ESR2, CYP19A1
28li-fraumeni syndrome10.0ESR2, CYP19A1
29osteoporosis, postmenopausal10.0ESR2, CYP19A1
30androgen insensitivity syndrome10.0AR, SRD5A2
31antley-bixler syndrome10.0CYP19A1, CYP17A1, CYP21A2
32endocrine gland cancer10.0CYP19A1, AR
33partial androgen insensitivity syndrome10.0AR, CYP19A1
34congenital adrenal hyperplasia10.0CYP17A1, CYP19A1, CYP21A2
35complete androgen insensitivity syndrome10.0AR, CYP19A1
36leydig cell tumor10.0CYP21A2, CYP19A1, CYP17A1
37adrenocortical carcinoma10.0CYP21A2, CYP19A1, CYP17A1
38short stature10.0CYP21A2, CYP19A1
39adrenal adenoma10.0CYP19A1, CYP21A2, CYP17A1
40prostate disease10.0AR, CYP19A1
41sertoli cell tumor10.0AR, CYP19A1
42germ cell cancer10.0ESR2, AR
43cryptorchidism10.0CYP19A1, AR
44leiomyoma10.0CYP19A1, ESR2, CYP17A1
45endometriosis10.0CYP17A1, CYP19A1, ESR2
46endometrial carcinoma10.0CYP17A1, CYP19A1, ESR2
47penis agenesis10.0SRD5A2, CYP17A1, AR
48graves' disease10.0ESR2, CYP21A2
49azoospermia10.0AR, ESR2, CYP21A2
50uterine fibroid9.9CYP19A1, ESR2, CYP21A2, CYP17A1

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to transsexualism

Symptoms for Transsexualism

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Drugs & Therapeutics for Transsexualism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Transsexualism

Drug clinical trials:

Search ClinicalTrials for Transsexualism

Search NIH Clinical Center for Transsexualism

Search CenterWatch for Transsexualism

Genetic Tests for Transsexualism

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Anatomical Context for Transsexualism

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Sources:
34MalaCards
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MalaCards organs/tissues related to Transsexualism:

34
Bone, Breast, Testes, Prostate, Pituitary, Brain, Thyroid, Cervix, Adipocyte

Animal Models for Transsexualism or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Transsexualism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5AR, ESR2, CYP19A1
2MP:00053797.7CYP19A1, ESR2, SRD5A2, AR
3MP:00053897.5AR, SRD5A2, ESR2, CYP19A1, CYP17A1

Publications for Transsexualism

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Sources:
53PubMed
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Articles related to Transsexualism:

(show top 50)    (show all 319)
idTitleAuthorsYear
1
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. (23857518)
2014
2
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. (23809495)
2013
3
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. (23970664)
2013
4
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. (23897544)
2013
5
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. (21074005)
2011
6
Karyotyping, is it worthwhile in transsexualism? (21114769)
2011
7
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. (19620824)
2010
8
Transsexualism--diagnostic and therapeutic aspects. (20806188)
2010
9
Transsexualism in Australia: a further statistic. (19227577)
2009
10
A common polymorphism of the SRD5A2 gene and transsexualism. (18000232)
2007
11
Effects of long-term androgen administration on breast tissue of female-to-male transsexuals. (16618941)
2006
12
High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. (15994752)
2005
13
Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. (16267416)
2005
14
Treatment of urethral stricture in a female-to-male transsexual with a tubulized flap from the labia minora. (15880292)
2005
15
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
16
Medical advances in transsexualism and the legal implications. (12605009)
2003
17
Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: effects of estrogenic treatment on bone metabolism of the male. (14515001)
2003
18
Masculinity, femininity, and transsexualism. (12462479)
2002
19
A psycho-endocrinological overview of transsexualism. (11580991)
2001
20
Sudden death by arrhythmogenic right ventricular dysplasia in a South American transsexual? (9717380)
1998
21
Homocystinuria and transsexualism. (8622374)
1996
22
Further insights into transsexualism. (8711070)
1996
23
Female-to-male transsexualism, heterosexual type: two cases. (7661657)
1995
24
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
25
Transsexualism. (2064661)
1991
26
Perceived parental rearing style, parental divorce and transsexualism: a controlled study. (2236370)
1990
27
Transsexualism and anatomic sex ratio reversal in Poland. (3265612)
1988
28
Gonadotropins and gonadal function in transsexualism and hypospadias. (3099183)
1986
29
A systems approach to child effeminacy and the prevention of adolescent transsexualism. (3782580)
1986
30
Transsexualism: ethical and legal aspects. (11658531)
1984
31
Psychological adjustment in transvestism and transsexualism. (7316917)
1981
32
Partnership in transsexualism. Part II. The nature of the partnership. (7247724)
1981
33
Gender identity conflicts in male transsexualism. (7362932)
1980
34
EEG abnormalities and transsexualism. (509010)
1979
35
Male transsexualism--a review of genital surgical reconstruction. (356612)
1978
36
Transsexualism and social attitudes. A case report. (1019364)
1976
37
Transsexualism in Vietnam. (1130982)
1975
38
Transsexualism in a fourteen-year-old male. (4653998)
1972
39
Family dynamics in male transsexualism. (5112328)
1971
40
Incidence and sex ratio of transsexualism in Sweden. (5565911)
1971
41
Male transsexualism: An endocrine study. (24179050)
1971
42
Transsexualism and surgical procedures. (4925941)
1971
43
A case of female transsexualism. (5514897)
1970
44
The desire for sexual transformation: a psychiatric evaluation of transsexualism. (5772927)
1969
45
Sex conversion operation in female transsexualism. (4179807)
1968
46
Transsexualism: considerations regarding sexual reassignment. (5726922)
1968
47
A case of female transsexualism. (6025196)
1967
48
Transsexualism: report of a case. (14427679)
1959
49
Homosexuality, transvestism and transsexualism; reflections on their etiology and differentiation. (13394762)
1957
50
Transsexualism and transvestism as psychosomatic and somatopsychic syndromes. (13148376)
1954

Variations for Transsexualism

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Expression for genes affiliated with Transsexualism

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for genes affiliated with Transsexualism

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Transsexualism according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CYP17A1, CYP19A1
2
Show member pathways
Estrogen biosynthesis61
Androstenedione and testosterone biosynthesis and metabolism p.161
9.5CYP17A1, CYP19A1
3
Show member pathways
9.3ESR2, CYP19A1
49.3ESR2, CYP19A1
5
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.2AR, CYP17A1
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.1AR, SRD5A2
79.1AR, CYP19A1
8
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
9
Show member pathways
9.1CYP21A2, CYP19A1, CYP17A1
10
Show member pathways
Nuclear Receptors39
9.0AR, ESR2
119.0ESR2, AR
12
Show member pathways
estradiol biosynthesis II39
androgen biosynthesis39
estradiol biosynthesis I39
progesterone biosynthesis39
9.0CYP17A1, CYP19A1, SRD5A2
13
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
14
Show member pathways
8.2CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
15
Show member pathways
8.2SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Compounds for genes affiliated with Transsexualism

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Sources:
46Novoseek, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 12DrugBank, 52PharmGKB, 3BitterDB
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Compounds related to Transsexualism according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1pregnanediol469.8CYP17A1, CYP21A2
2es 936629.6SRD5A2, SRD5A3
311b-Hydroxyprogesterone259.6CYP21A2, CYP17A1
4pcb 126469.5CYP17A1, CYP21A2, CYP19A1
5prochloraz469.4CYP19A1, ESR2
617-hydroxyprogesterone46 2510.4CYP19A1, CYP21A2, CYP17A1
7hpte46 3010.3ESR2, AR
8leuprolide acetate469.2CYP19A1, ESR2, CYP21A2
9clomiphene citrate469.2CYP19A1, CYP21A2, ESR2
10abiraterone acetate469.1AR, CYP17A1
11vinclozolin469.1AR, CYP19A1
12aminoglutethimide46 1210.0AR, CYP21A2, CYP19A1
13dutasteride46 1210.0AR, SRD5A2, CYP19A1
14nandrolone46 259.9AR, CYP19A1, ESR2
155alpha-androstane-3alpha,17beta-diol468.9AR, ESR2, CYP19A1
16fulvestrant46 52 30 1211.8AR, CYP19A1, ESR2
17levonorgestrel46 62 30 1211.8AR, CYP19A1, ESR2
18bicalutamide46 62 1210.8ESR2, CYP19A1, AR
194-tert-octylphenol468.7AR, ESR2
20ribonucleic acid468.7SRD5A2, CYP21A2, ESR2, CYP17A1
21progestins468.7AR, ESR2, CYP19A1
22ketoconazole46 30 25 1211.7CYP21A2, CYP19A1, CYP17A1, AR
23finasteride46 62 25 1211.7CYP19A1, AR, SRD5A3, SRD5A2
24dehydroepiandrosterone sulfate468.7CYP21A2, CYP17A1, AR, CYP19A1
25valine468.6CYP21A2, CYP17A1, SRD5A2, AR
26exemestane46 52 62 1211.5CYP17A1, ESR2, CYP19A1, AR
27bisphenol a468.5CYP19A1, CYP17A1, ESR2, AR
28letrozole46 52 62 1211.5CYP17A1, ESR2, CYP19A1, AR
29steroidal468.5AR, ESR2, CYP17A1, CYP19A1
30diethylstilbestrol46 30 1210.5AR, CYP17A1, CYP19A1, ESR2
31progestin468.5CYP17A1, CYP19A1, ESR2, AR
32estrone46 30 25 1211.5CYP19A1, AR, ESR2, CYP17A1
33chloramphenicol46 3 52 1211.4AR, ESR2, CYP21A2, CYP17A1
34tamoxifen46 52 30 1211.3CYP17A1, AR, ESR2, CYP19A1
35dhea468.1CYP21A2, AR, CYP19A1, CYP17A1, ESR2
36gnrh468.1CYP21A2, ESR2, AR, CYP17A1, CYP19A1
37genistein46 30 62 3 25 1213.0AR, CYP17A1, ESR2, CYP19A1, CYP21A2
38cycloheximide468.0CYP19A1, CYP21A2, ESR2, CYP17A1, AR
39vitamin d468.0AR, SRD5A2, ESR2, CYP19A1, CYP17A1
40dexamethasone46 52 30 1210.9AR, CYP17A1, ESR2, CYP21A2, CYP19A1
4117beta-hydroxysteroid467.6AR, CYP21A2, CYP19A1, CYP17A1, ESR2, SRD5A2
423beta-hydroxysteroid467.6AR, SRD5A2, ESR2, CYP21A2, CYP19A1, CYP17A1
43androstenedione46 258.6AR, SRD5A2, ESR2, CYP19A1, CYP17A1, CYP21A2
44dihydrotestosterone46 30 25 1210.6AR, CYP17A1, SRD5A2, CYP19A1, CYP21A2, ESR2
45estradiol46 25 129.6CYP17A1, CYP21A2, SRD5A2, CYP19A1, AR, ESR2
46progesterone46 30 62 25 1211.5AR, CYP21A2, CYP17A1, CYP19A1, SRD5A2, ESR2
47steroid467.5CYP19A1, CYP17A1, CYP21A2, ESR2, SRD5A2, AR
48arginine467.5CYP17A1, CYP19A1, AR, SRD5A2, ESR2, CYP21A2
49estrogen467.5CYP21A2, ESR2, CYP17A1, CYP19A1, AR, SRD5A2
50testosterone46 62 25 1210.2CYP19A1, ESR2, SRD5A2, CYP21A2, SRD5A3, AR

GO Terms for genes affiliated with Transsexualism

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Sources:
17Gene Ontology
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Cellular components related to Transsexualism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.2SRD5A3, CYP19A1, CYP17A1
2endoplasmic reticulum membraneGO:0057897.9SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1

Biological processes related to Transsexualism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:0067049.7CYP21A2, CYP17A1
2steroid biosynthetic processGO:0066949.5CYP19A1, CYP17A1
3androgen metabolic processGO:0082099.4CYP19A1, SRD5A2
4androgen biosynthetic processGO:0067029.4CYP17A1, SRD5A2, SRD5A3
5sterol metabolic processGO:0161259.3CYP21A2, CYP19A1, CYP17A1
6xenobiotic metabolic processGO:0068059.2CYP21A2, CYP19A1, CYP17A1
7sex differentiationGO:0075489.1CYP17A1, AR
8steroid metabolic processGO:0082028.4SRD5A3, SRD5A2, CYP21A2, CYP19A1, CYP17A1
9small molecule metabolic processGO:0442818.3CYP17A1, CYP19A1, CYP21A2, SRD5A2, SRD5A3
10cell-cell signalingGO:0072678.2AR, SRD5A2, ESR2

Molecular functions related to Transsexualism according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
13-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.7SRD5A3, SRD5A2
2cholestenone 5-alpha-reductase activityGO:0477519.7SRD5A3, SRD5A2
3steroid bindingGO:0054969.3ESR2, CYP21A2
4oxygen bindingGO:0198259.2CYP19A1, CYP17A1
5heme bindingGO:0200379.2CYP21A2, CYP19A1, CYP17A1
6iron ion bindingGO:0055069.1CYP17A1, CYP19A1, CYP21A2
7ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.0AR, ESR2

Products for genes affiliated with Transsexualism

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Sources for Transsexualism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet