MCID: TRN001
MIFTS: 58

Transthyretin Amyloidosis malady

Genetic diseases, Neuronal diseases, Bone diseases, Rare diseases, Cardiovascular diseases categories

Summaries for Transthyretin Amyloidosis

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22Genetics Home Reference, 66Wikipedia, 48OMIM, 34MalaCards
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Genetics Home Reference:22 Transthyretin amyloidosis is a slowly progressive condition characterized by the buildup of abnormal deposits of a protein called amyloid (amyloidosis) in the body's organs and tissues. These protein deposits most frequently occur in the peripheral nervous system, which is made up of nerves connecting the brain and spinal cord to muscles and sensory cells that detect sensations such as touch, pain, heat, and sound. Protein deposits in these nerves result in a loss of sensation in the extremities (peripheral neuropathy). The autonomic nervous system, which controls involuntary body functions such as blood pressure, heart rate, and digestion, may also be affected by amyloidosis. In some cases, the brain and spinal cord (central nervous system) are affected. Other areas of amyloidosis include the heart, kidneys, eyes, and gastrointestinal tract. The age at which symptoms begin to develop varies widely among individuals with this condition, and is typically between ages 20 and 70.

MalaCards: Transthyretin Amyloidosis, also known as amyloidosis, hereditary, transthyretin-related, is related to familial transthyretin amyloidosis and amyloidosis. An important gene associated with Transthyretin Amyloidosis is TTR (transthyretin), and among its related pathways are Diseases associated with visual transduction and Visual Cycle in Retinal Rods. The compounds thioflavin t and purpurin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and heart, and related mouse phenotypes are cardiovascular system and muscle.

Wikipedia:66 Familial amyloid polyneuropathy (FAP), also called transthyretin-related hereditary amyloidosis,... more...

Description from OMIM:48 105210

Aliases & Classifications for Transthyretin Amyloidosis

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Sources:
9Disease Ontology, 22Genetics Home Reference, 10diseasecard, 48OMIM, 63UMLS, 50Orphanet, 46Novoseek, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
transthyretin amyloid polyneuropathy:
Inheritance: Autosomal dominant; Age of onset: Adulthood; Age of death: Adult
transthyretin-related familial amyloid cardiomyopathy:
Inheritance: Autosomal dominant; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

transthyretin amyloidosis 9 22
amyloidosis, hereditary, transthyretin-related 9 10 48 63
type i familial amyloid polyneuropathy 22 46
transthyretin-related familial amyloid cardiomyopathy 50
familial amyloid neuropathy, portuguese type 63
portuguese type familial amyloid neuropathy 22
type ii familial amyloid polyneuropathy 22
transthyretin amyloid polyneuropathy 50
portuguese polyneuritic amyloidosis 22
amyloid polyneuropathy, swiss type 63
ttr-related amyloid cardiomyopathy 50
swiss type amyloid polyneuropathy 22
transthyretin amyloid cardiopathy 50
transthyretin amyloid neuropathy 50
ttr-related cardiac amyloidosis 50
familial amyloid polyneuropathy 50
ttr amyloid neuropathy 50
attr cardiomyopathy 50


External Ids:

Disease Ontology9 DOID:0050638
OMIM48 105210
ICD10 via Orphanet27 E85.1, E85.0
SNOMED-CT via Orphanet60 42295001

Related Diseases for Transthyretin Amyloidosis

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18GeneCards, 19GeneDecks
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Diseases in the Transthyretin Amyloidosis family:

Familial Transthyretin Amyloidosis

Diseases related to Transthyretin Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1familial transthyretin amyloidosis31.5TTR
2amyloidosis31.4RBP4, NPPB, SNCA, CLU, TTR
3polyneuropathy30.6TTR, RBP4
4pure autonomic failure30.3SNCA, TTR
5spinocerebellar ataxia30.3SNCA, ATXN1
6amyloid neuropathy10.5
7carpal tunnel syndrome10.5
8lattice corneal dystrophy10.4
9familial amyloid cardiomyopathy10.4
10cerebral amyloid angiopathy10.3
11cerebritis10.3
12corneal dystrophy10.3
13familial amyloid polyneuropathy type ii10.3
14finnish type amyloidosis10.3
15familial amyloidosis, finnish type10.3
16familial amyloid polyneuropathy type 110.3
17lattice corneal dystrophy type ii10.3
18neuropathy10.3
19hereditary amyloidosis10.3
20hepatitis c10.2
21machado-joseph disease10.2
22neuronitis10.2
23diabetes mellitus10.2
24hereditary neuropathy with liability to pressure palsies10.2
25al amyloidosis10.2
26hereditary neuropathy with liability to pressure palsy10.2
27lattice corneal dystrophy type 110.2
28lattice corneal dystrophy type 3a10.2
29dysphagia10.2
30hereditary neuropathies10.2
31siderosis10.1
32autonomic neuropathy10.1
33dementia10.1
34diarrhea10.1
35hepatitis10.1
36mononeuropathy10.1
37peripheral neuropathy10.1
38ataxia10.1
39headache10.1
40amyotrophic lateral sclerosis 2, juvenile10.1
41endotheliitis10.1
42superficial siderosis10.1
43senile systemic amyloidosis10.1
44galactosemia10.1TTR
45familial restrictive cardiomyopathy10.1TTR, NPPB
46retinal degeneration10.0CLU
47spinocerebellar ataxia type 310.0ATXN1, SNCA
48hypervitaminosis a10.0RBP4, TTR
49keratomalacia10.0TTR, RBP4
50protein-energy malnutrition10.0TTR, RBP4

Graphical network of the top 20 diseases related to Transthyretin Amyloidosis:



Diseases related to transthyretin amyloidosis

Symptoms for Transthyretin Amyloidosis

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48OMIM
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Symptoms by clinical synopsis from OMIM:

105210

Clinical features from OMIM:

105210

Drugs & Therapeutics for Transthyretin Amyloidosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Transthyretin Amyloidosis

Drug clinical trials:

Search ClinicalTrials for Transthyretin Amyloidosis

Search NIH Clinical Center for Transthyretin Amyloidosis

Search CenterWatch for Transthyretin Amyloidosis

Genetic Tests for Transthyretin Amyloidosis

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Anatomical Context for Transthyretin Amyloidosis

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34MalaCards
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MalaCards organs/tissues related to Transthyretin Amyloidosis:

34
Liver, Bone, Heart, Testes, Kidney, Endothelial

Animal Models for Transthyretin Amyloidosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Transthyretin Amyloidosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1CLU, SNCA, RBP4, NPPB
2MP:00053697.9ATXN1, CLU, RBP4, NPPB
3MP:00053767.3ATXN1, TTR, CLU, SNCA, RBP4

Publications for Transthyretin Amyloidosis

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53PubMed
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Articles related to Transthyretin Amyloidosis:

(show top 50)    (show all 88)
idTitleAuthorsYear
1
Derivatization strategies for CE-LIF analysis of biomarkers: towards a clinical diagnostic of familial transthyretin amyloidosis. (24254376)
2013
2
Safety and efficacy of RNAi therapy for transthyretin amyloidosis. (23984729)
2013
3
Systemic transthyretin amyloidosis in a patient with bent spine syndrome. (23638719)
2013
4
Transthyretin amyloidosis with pulmonary involvement in a patient with monoclonal gammapathy. (24142783)
2013
5
Role of natriuretic peptide to predict cardiac abnormalities in patients with hereditary transthyretin amyloidosis. (23964755)
2013
6
Liver transplantation and transthyretin amyloidosis. (23169427)
2013
7
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis? (22362898)
2012
8
I+-Synuclein aggregation in the saliva of familial transthyretin amyloidosis: a potential biomarker. (22591216)
2012
9
Allele specific expression of the transthyretin gene in swedish patients with hereditary transthyretin amyloidosis (ATTR V30M) is similar between the two alleles. (23185504)
2012
10
Pathogenesis of transthyretin amyloidosis. (22452550)
2012
11
Sporadic transthyretin amyloidosis with a novel TTR gene mutation misdiagnosed as primary amyloidosis. (22580845)
2012
12
Cardiac transthyretin amyloidosis. (22888163)
2012
13
Familial Transthyretin Amyloidosis with Variant Asp38Ala Presenting with Orthostatic Hypotension and Chronic Diarrhea. (23346293)
2012
14
Green tea halts progression of cardiac transthyretin amyloidosis: an observational report. (22584381)
2012
15
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension. (22579241)
2012
16
Transthyretin amyloidosis and the kidney. (22537653)
2012
17
Development of cardiomyopathy after liver transplantation in Swedish hereditary transthyretin amyloidosis (ATTR) patients. (22080763)
2011
18
The relative amounts of plasma transthyretin forms in familial transthyretin amyloidosis: a quantitative analysis by Fourier transform ion-cyclotron resonance mass spectrometry. (22080762)
2011
19
Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation. (20935325)
2011
20
Characterization of end-stage renal disease after liver transplantation in transthyretin amyloidosis (ATTR V30M). (21335185)
2011
21
Successful heart and liver transplantation in a Swiss patient with Glu89Lys transthyretin amyloidosis. (21383601)
2011
22
Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation. (21117248)
2010
23
Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. (19618439)
2009
24
Clusterin regulates transthyretin amyloidosis. (19664600)
2009
25
Familial transthyretin amyloidosis]. (20143571)
2009
26
Extensive intracranial microbleeds in transthyretin amyloidosis. (19054206)
2008
27
Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey. (18192580)
2008
28
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. (17948976)
2007
29
Identification of a novel TTR Gly67Glu mutant and the first case series of familial transthyretin amyloidosis in Hong Kong Chinese. (17968690)
2007
30
A novel type of familial transthyretin amyloidosis, ATTR Asn124Ser, with co-localization of kappa light chains. (17577687)
2007
31
Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores. (17360344)
2007
32
Biochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosis. (17062384)
2006
33
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. (16195386)
2005
34
Transmission of systemic transthyretin amyloidosis by means of domino liver transplantation. (15930432)
2005
35
Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis. (15966751)
2005
36
Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. (15588697)
2004
37
Transthyretin amyloidosis presenting with multifocal demyelinating mononeuropathies. (14755500)
2004
38
Portuguese-type amyloidosis (transthyretin amyloidosis, ATTR V30M). (12832749)
2003
39
Hereditary transthyretin amyloidosis from a Scandinavian perspective. (12930231)
2003
40
Identification of a novel transthyretin Thr59Lys/Arg104His. A case of compound heterozygosity in a Chinese patient diagnosed with familial transthyretin amyloidosis. (12440486)
2002
41
Cutaneous lymphatic amyloid deposits in "Hungarian-type" familial transthyretin amyloidosis: a case report. (11966704)
2002
42
Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. (11866053)
2002
43
Hereditary transthyretin amyloidosis: molecular basis and therapeutical strategies. (14987380)
2002
44
Laboratory assessment of transthyretin amyloidosis. (12553428)
2002
45
Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis. (10524283)
1999
46
Investigation into thiol conjugation of transthyretin in hereditary transthyretin amyloidosis. (9767365)
1998
47
A simple screening test for variant transthyretins associated with familial transthyretin amyloidosis using isoelectric focusing. (9748569)
1998
48
Transthyretin amyloidosis: a new mutation associated with dementia. (9066351)
1997
49
Familial Transthyretin Amyloidosis (20301373)
1993
50
Two-tiered DNA-based diagnosis of transthyretin amyloidosis reveals two novel point mutations. (2046936)
1991

Variations for Transthyretin Amyloidosis

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Transthyretin Amyloidosis:

65 (show all 73)
id Symbol AA change Variation ID SNP ID
1TTRp.Cys30ArgVAR_007547
2TTRp.Asp38GluVAR_007548
3TTRp.Asp38GlyVAR_007549
4TTRp.Val40IleVAR_007550
5TTRp.Pro44SerVAR_007551rs11541790
6TTRp.Val50AlaVAR_007552
7TTRp.Val50LeuVAR_007553
8TTRp.Val50MetVAR_007554rs28933979
9TTRp.Phe53IleVAR_007555
10TTRp.Phe53LeuVAR_007556
11TTRp.Ala56ProVAR_007557
12TTRp.Glu62GlyVAR_007558rs11541796
13TTRp.Ala65AspVAR_007559
14TTRp.Ala65ThrVAR_007560
15TTRp.Gly67AlaVAR_007561
16TTRp.Gly67ArgVAR_007562
17TTRp.Gly67ValVAR_007563
18TTRp.Thr69AlaVAR_007564
19TTRp.Ser70IleVAR_007565
20TTRp.Ser70ArgVAR_007566
21TTRp.Ser72ProVAR_007567
22TTRp.Glu74GlyVAR_007568
23TTRp.Leu75ProVAR_007569
24TTRp.Leu78HisVAR_007570
25TTRp.Leu78ArgVAR_007571
26TTRp.Thr79LysVAR_007572
27TTRp.Thr80AlaVAR_007573
28TTRp.Glu81LysVAR_007574
29TTRp.Phe84LeuVAR_007575
30TTRp.Ile88LeuVAR_007576
31TTRp.Tyr89HisVAR_007577
32TTRp.Lys90AsnVAR_007578
33TTRp.Val91AlaVAR_007579
34TTRp.Ile93ValVAR_007580
35TTRp.Ser97TyrVAR_007582
36TTRp.Ile104AsnVAR_007583
37TTRp.Ile104SerVAR_007584
38TTRp.Glu109GlnVAR_007585
39TTRp.Ala111SerVAR_007587
40TTRp.Ala117GlyVAR_007588
41TTRp.Ile127ValVAR_007592
42TTRp.Leu131MetVAR_007594
43TTRp.Tyr134CysVAR_007595
44TTRp.Tyr136SerVAR_007596
45TTRp.Val142IleVAR_007600rs28933980
46TTRp.Val48MetVAR_010658
47TTRp.Glu109LysVAR_010659
48TTRp.Leu32ProVAR_038959
49TTRp.Ser43AsnVAR_038961
50TTRp.Val50GlyVAR_038962
51TTRp.Phe53ValVAR_038964
52TTRp.Arg54ThrVAR_038965
53TTRp.Lys55AsnVAR_038966
54TTRp.Asp58AlaVAR_038967
55TTRp.Asp58ValVAR_038968
56TTRp.Trp61LeuVAR_038969
57TTRp.Glu62AspVAR_038970rs11541796
58TTRp.Phe64SerVAR_038971
59TTRp.Ala65SerVAR_038972
60TTRp.Gly67GluVAR_038973
61TTRp.Thr69IleVAR_038974
62TTRp.Gly73GluVAR_038975
63TTRp.Glu74LysVAR_038976
64TTRp.Leu75GlnVAR_038977
65TTRp.Glu81GlyVAR_038978
66TTRp.Tyr98PheVAR_038979
67TTRp.Ile104ThrVAR_038980
68TTRp.Ala117SerVAR_038982
69TTRp.Thr126AsnVAR_038984
70TTRp.Ile127MetVAR_038985
71TTRp.Ala140SerVAR_038986
72TTRp.Val142AlaVAR_038987
73TTRp.Asn144SerVAR_038988

Clinvar genetic disease variations for Transthyretin Amyloidosis:

1 (show all 40)
id Gene Name Type Significance SNP ID Assembly Location
1TTRNM_000371.3(TTR): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs28933979GRCh37Chr 18, 29172937: 29172937
2TTRNM_000371.3(TTR): c.157T> A (p.Phe53Ile)single nucleotide variantPathogenicrs121918068GRCh37Chr 18, 29172946: 29172946
3TTRNM_000371.3(TTR): c.401A> G (p.Tyr134Cys)single nucleotide variantPathogenicrs121918075GRCh37Chr 18, 29178595: 29178595
4TTRNM_000371.3(TTR): c.233T> A (p.Leu78His)single nucleotide variantPathogenicrs121918069GRCh37Chr 18, 29175115: 29175115
5TTRNM_000371.3(TTR): c.238A> G (p.Thr80Ala)single nucleotide variantPathogenicrs121918070GRCh37Chr 18, 29175120: 29175120
6TTRNM_000371.3(TTR): c.290C> A (p.Ser97Tyr)single nucleotide variantPathogenicrs121918071GRCh37Chr 18, 29175172: 29175172
7TTRNM_000371.3(TTR): c.311T> G (p.Ile104Ser)single nucleotide variantPathogenicrs121918072GRCh37Chr 18, 29175193: 29175193
8TTRNM_000371.3(TTR): c.391C> A (p.Leu131Met)single nucleotide variantPathogenicrs121918073GRCh37Chr 18, 29178585: 29178585
9TTRNM_000371.3(TTR): c.424G> A (p.Val142Ile)single nucleotide variantPathogenicrs76992529GRCh37Chr 18, 29178618: 29178618
10TTRNM_000371.3(TTR): c.328C> A (p.His110Asn)single nucleotide variantLikely benign, Pathogenicrs121918074GRCh37Chr 18, 29175210: 29175210
11TTRNM_000371.3(TTR): c.185A> G (p.Glu62Gly)single nucleotide variantPathogenicrs11541796GRCh37Chr 18, 29172974: 29172974
12TTRNM_000371.3(TTR): c.210T> G (p.Ser70Arg)single nucleotide variantLikely pathogenic, Pathogenicrs121918076GRCh37Chr 18, 29175092: 29175092
13TTRNM_000371.3(TTR): c.149T> C (p.Val50Ala)single nucleotide variantPathogenicrs79977247GRCh37Chr 18, 29172938: 29172938
14TTRNM_000371.3(TTR): c.166G> C (p.Ala56Pro)single nucleotide variantPathogenicrs121918077GRCh37Chr 18, 29172955: 29172955
15TTRNM_000371.3(TTR): c.233T> G (p.Leu78Arg)single nucleotide variantPathogenicrs121918069GRCh37Chr 18, 29175115: 29175115
16TTRNM_000371.3(TTR): c.199G> C (p.Gly67Arg)single nucleotide variantPathogenicrs387906523GRCh37Chr 18, 29172988: 29172988
17TTRNM_000371.3(TTR): c.133G> A (p.Ala45Thr)single nucleotide variantPathogenicrs104894664GRCh37Chr 18, 29172922: 29172922
18TTRNM_000371.3(TTR): c.224T> C (p.Leu75Pro)single nucleotide variantPathogenicrs121918079GRCh37Chr 18, 29175106: 29175106
19TTRNM_000371.3(TTR): c.209G> T (p.Ser70Ile)single nucleotide variantPathogenicrs121918080GRCh37Chr 18, 29175091: 29175091
20TTRNM_000371.3(TTR): c.148G> C (p.Val50Leu)single nucleotide variantPathogenicrs28933979GRCh37Chr 18, 29172937: 29172937
21TTRNM_000371.3(TTR): c.205A> G (p.Thr69Ala)single nucleotide variantPathogenicrs121918081GRCh37Chr 18, 29175087: 29175087
22TTRNM_000371.3(TTR): c.325G> C (p.Glu109Gln)single nucleotide variantPathogenicrs121918082GRCh37Chr 18, 29175207: 29175207
23TTRNM_000371.3(TTR): c.270A> C (p.Lys90Asn)single nucleotide variantPathogenicrs267607160GRCh37Chr 18, 29175152: 29175152
24TTRNM_000371.3(TTR): c.88T> C (p.Cys30Arg)single nucleotide variantPathogenicrs121918083GRCh37Chr 18, 29172877: 29172877
25TTRNM_000371.3(TTR): c.272T> C (p.Val91Ala)single nucleotide variantPathogenicrs121918084GRCh37Chr 18, 29175154: 29175154
26TTRNM_000371.3(TTR): c.262A> T (p.Ile88Leu)single nucleotide variantPathogenicrs121918085GRCh37Chr 18, 29175144: 29175144
27TTRNM_000371.3(TTR): c.241G> A (p.Glu81Lys)single nucleotide variantPathogenicrs121918086GRCh37Chr 18, 29175123: 29175123
28TTRNM_000371.3(TTR): c.350C> G (p.Ala117Gly)single nucleotide variantPathogenicrs121918087GRCh37Chr 18, 29178544: 29178544
29TTRNM_000371.3(TTR): c.379A> G (p.Ile127Val)single nucleotide variantPathogenicrs121918089GRCh37Chr 18, 29178573: 29178573
30TTRNM_000371.3(TTR): c.200G> C (p.Gly67Ala)single nucleotide variantPathogenicrs121918090GRCh37Chr 18, 29172989: 29172989
31TTRNM_000371.3(TTR): c.250T> C (p.Phe84Leu)single nucleotide variantPathogenicrs121918091GRCh37Chr 18, 29175132: 29175132
32TTRNM_000371.3(TTR): c.118G> A (p.Val40Ile)single nucleotide variantPathogenicrs121918093GRCh37Chr 18, 29172907: 29172907
33TTRNM_000371.3(TTR): c.157T> C (p.Phe53Leu)single nucleotide variantPathogenicrs121918068GRCh37Chr 18, 29172946: 29172946
34TTRNM_000371.3(TTR): c.95T> C (p.Leu32Pro)single nucleotide variantPathogenicrs121918094GRCh37Chr 18, 29172884: 29172884
35TTRNM_000371.3(TTR): c.371G> A (p.Arg124His)single nucleotide variantPathogenicrs121918095GRCh37Chr 18, 29178565: 29178565
36TTRNM_000371.3(TTR): c.199G> A (p.Gly67Arg)single nucleotide variantPathogenicrs387906523GRCh37Chr 18, 29172988: 29172988
37TTRNM_000371.3(TTR): c.424_426delGTC (p.Val142del)deletionLikely pathogenic, Pathogenicrs121918096GRCh37Chr 18, 29178618: 29178620
38TTRNM_000371.3(TTR): c.191T> C (p.Phe64Ser)single nucleotide variantPathogenicrs104894665GRCh37Chr 18, 29172980: 29172980
39TTRNM_000371.3(TTR): c.113A> G (p.Asp38Gly)single nucleotide variantPathogenicrs121918098GRCh37Chr 18, 29172902: 29172902
40TTRNM_000371.3(TTR): c.349G> T (p.Ala117Ser)single nucleotide variantPathogenicrs267607161GRCh37Chr 18, 29178543: 29178543

Expression for genes affiliated with Transthyretin Amyloidosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Transthyretin Amyloidosis

Search GEO for disease gene expression data for Transthyretin Amyloidosis.

Pathways for genes affiliated with Transthyretin Amyloidosis

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51PathCards, 56Reactome, 54QIAGEN, 39NCBI BioSystems Database
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Compounds for genes affiliated with Transthyretin Amyloidosis

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46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Transthyretin Amyloidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1thioflavin t4610.0TTR, SNCA
2purpurin469.9RBP4, TTR
3retinyl palmitate46 2510.8TTR, RBP4
4guanidine hydrochloride469.8SNCA, TTR
5lutein469.8RBP4, TTR
6tocopherol469.8RBP4, TTR
7cellulose acetate469.8RBP4, TTR
8phosphorus469.8RBP4, TTR
9isoleucine469.7TTR, RBP4
10betacarotene469.7RBP4, TTR
11sodium dodecylsulfate469.6TTR, SNCA
12bicarbonate469.6SNCA, NPPB
13spermidine46 30 25 1212.5SNCA, CLU
14pioglitazone30 46 52 1212.5RBP4, NPPB
15levodopa46 1210.5SNCA, NPPB
16spermine30 46 25 1212.5CLU, SNCA
17norepinephrine46 25 1211.5SNCA, TTR, NPPB
18alpha tocopherol469.4SNCA, TTR, RBP4
19glutamine469.4ATXN1, SNCA, TTR
20valine469.4TTR, SNCA, RBP4
21triiodothyronine469.4TTR, RBP4, NPPB
22uric acid46 2510.4RBP4, NPPB, TTR
23vitamin-e469.3TTR, RBP4
24thyroxine46 2510.3NPPB, TTR, RBP4
25adenylate469.2SNCA, TTR, RBP4
26creatinine469.2RBP4, NPPB, TTR
27catecholamine469.2NPPB, SNCA
28homocysteine46 2510.1TTR, CLU, NPPB
29paraffin469.1CLU, SNCA, TTR
30vitamin d469.1NPPB, CLU, TTR
31folate469.0CLU, RBP4, TTR
32magnesium46 25 1211.0NPPB, SNCA, RBP4
33heparin46 30 25 1212.0SNCA, CLU, NPPB
34phospholipid468.9RBP4, SNCA, CLU
35iron46 259.9NPPB, RBP4, SNCA, TTR
36glucose468.8SNCA, TTR, NPPB, RBP4
37progesterone46 30 62 25 1212.7NPPB, CLU, RBP4
38cholesterol46 30 25 1211.6SNCA, TTR, CLU, RBP4
39steroid468.6CLU, NPPB, RBP4
40lactate468.5TTR, CLU, RBP4, NPPB
41dexamethasone46 52 30 1211.5NPPB, RBP4, CLU, TTR
42zinc46 259.5TTR, CLU, NPPB, RBP4
43fatty acid468.5NPPB, SNCA, RBP4, CLU
44estrogen468.5TTR, CLU, RBP4, NPPB
45oxygen46 259.4RBP4, SNCA, CLU, NPPB
46lipid468.4CLU, RBP4, NPPB, SNCA
47dopamine46 30 25 1211.1NPPB, RBP4, TTR, SNCA, CLU
48cysteine468.1TTR, CLU, SNCA, RBP4, NPPB
49serine468.1TTR, SNCA, CLU, RBP4, NPPB
50testosterone46 62 25 1210.6RBP4, ATXN1, TTR, CLU, SNCA, NPPB

GO Terms for genes affiliated with Transthyretin Amyloidosis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Transthyretin Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.6RBP4, NPPB, TTR
2extracellular spaceGO:0056158.1CLU, TTR, NPPB, RBP4
3extracellular regionGO:0055767.5NPPB, RBP4, SNCA, CLU, TTR

Biological processes related to Transthyretin Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol metabolic processGO:0425729.5RBP4, TTR
2regulation of excitatory postsynaptic membrane potentialGO:0600799.5SNCA, ATXN1
3phototransduction, visible lightGO:0076039.4RBP4, TTR
4adult locomotory behaviorGO:0083449.4ATXN1, SNCA
5retinoid metabolic processGO:0015239.1RBP4, TTR

Molecular functions related to Transthyretin Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5NPPB, TTR
2identical protein bindingGO:0428028.8SNCA, TTR, ATXN1

Products for genes affiliated with Transthyretin Amyloidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Transthyretin Amyloidosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet