MCID: TRN003
MIFTS: 43

Transverse Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Transverse Colon Cancer

MalaCards integrated aliases for Transverse Colon Cancer:

Name: Transverse Colon Cancer 12 14
Malignant Neoplasm of Transverse Colon 69
Malignant Tumor of Transverse Colon 12
Ca Transverse Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:261
ICD10 33 C18.4
ICD9CM 35 153.1
UMLS 69 C0153434

Summaries for Transverse Colon Cancer

MalaCards based summary : Transverse Colon Cancer, also known as malignant neoplasm of transverse colon, is related to acute pulmonary heart disease and classic hairy cell leukemia. An important gene associated with Transverse Colon Cancer is ETFA (Electron Transfer Flavoprotein Alpha Subunit), and among its related pathways/superpathways are Endometrial cancer and Keratinization. The drugs Fluorouracil and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and pancreas, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Related Diseases for Transverse Colon Cancer

Diseases related to Transverse Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
id Related Disease Score Top Affiliating Genes
1 acute pulmonary heart disease 10.7 COL17A1 DSC2 DSC3
2 classic hairy cell leukemia 10.7 COL17A1 DSC2 DSC3
3 familial renal oncocytoma 10.6 KRT20 PMS2
4 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 MLH1 MSH2
5 limb ischemia 10.6 HRAS KRAS
6 severe pre-eclampsia 10.6 HRAS KRAS
7 psoriasis 10.6 CD6 MLH1 MSH2
8 bone giant cell tumor 10.6 KRT20 KRT7
9 cecum adenocarcinoma 10.5 KRAS KRT20 MLH1
10 rectum adenoma 10.5 KRT20 KRT7
11 schimmelpenning-feuerstein-mims syndrome, somatic mosaic 10.5 HRAS KRAS
12 periosteal osteogenic sarcoma 10.5 KRT20 KRT7
13 sensory system cancer 10.5 KRT20 KRT7
14 melanocytic nevus syndrome, congenital, somatic 10.5 HRAS MLH1 MSH2
15 steroid-induced glaucoma - borderline 10.5 KRT20 KRT7
16 ludwig's angina 10.5 KRT20 KRT7
17 tabes dorsalis 10.5 HRAS KRAS KRT20
18 lung occult small cell carcinoma 10.5 KRT20 KRT7
19 fibroepithelial polyp of urethra 10.5 KRT20 KRT7
20 migraine with aura 10.5 HRAS KRAS KRT20
21 fibroma 10.5 GNAS KRAS KRT20
22 clear cell squamous cell skin carcinoma 10.4 KRT20 KRT7
23 small intestine cancer, childhood 10.4 KRT20 KRT7
24 cellular myxoid liposarcoma 10.4 MLH1 MSH2 MSH6
25 thyroid gland disease 10.4 MLH1 MSH2
26 bardet-biedl syndrome 10.3 MLH1 MSH2 MSH6
27 parasitic protozoa infectious disease 10.3 KRAS PMS2
28 cavernous sinus thrombosis 10.3 KRAS KRT20 KRT7
29 bile duct mucinous adenocarcinoma 10.3 KRAS KRT7
30 chronic neutrophilic leukemia 10.3 KRT20 KRT7
31 congenital hypomyelination neuropathy 10.3 HRAS KRAS MLH1 MSH2
32 dysembryoplastic neuroepithelial tumor 10.2 KRT20 KRT7 MSH2
33 adenocarcinoma in situ 10.2 HRAS KRAS KRT7
34 endometriosis of uterus 10.2 KRAS KRT7 MLH1
35 diffuse pulmonary fibrosis 10.2 HRAS KRAS KRT7
36 apocrine adenocarcinoma 10.2 KRAS KRT20 KRT7
37 ovarian melanoma 10.2 KRT20 KRT7 MSH6
38 sertoli-leydig cell tumor 10.1 HRAS KRAS MLH1 MSH2
39 large intestine adenocarcinoma 10.1 MLH1 MSH2 MSH6 PMS2
40 optic nerve sheath meningioma 10.1 MLH1 MSH2 MSH6 PMS2
41 benign fibrous mesothelioma 10.1 MLH1 MSH2 MSH6 PMS2
42 cataract 27, nuclear progressive 10.1 MLH1 MSH2 MSH6 PMS2
43 arrhythmogenic right ventricular cardiomyopathy 10.1 KRAS MLH1 MSH2 MSH6
44 benign ependymoma 10.1 MLH1 MSH2 MSH6 PMS2
45 auditory neuropathy 10.1 MSH2 MSH6
46 muir-torre syndrome 10.1 MLH1 MSH2 MSH6 PMS2
47 mismatch repair cancer syndrome 10.1 MLH1 MSH2 MSH6 PMS2
48 lymphoplasmacytic lymphoma 10.1 MLH1 MSH2 MSH6 PMS2
49 y-linked disease 10.1 MLH1 MSH2 MSH6 PMS2
50 perivascular epithelioid cell tumor 10.0 KRT20 KRT7 THBD

Comorbidity relations with Transverse Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Transverse Colon Cancer:



Diseases related to Transverse Colon Cancer

Symptoms & Phenotypes for Transverse Colon Cancer

GenomeRNAi Phenotypes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.17 KRAS MLH1 MSH6 PIK3C2A PMS2 THBD

MGI Mouse Phenotypes related to Transverse Colon Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CD6 CYP27A1 GNAS HCK HRAS KRAS
2 integument MP:0010771 9.76 HRAS KRAS MLH1 MSH2 MSH6 THBD
3 neoplasm MP:0002006 9.56 HCK HRAS KRAS MLH1 MSH2 MSH6
4 renal/urinary system MP:0005367 9.17 CYP27A1 GNAS HRAS KRAS KRT7 PIK3C2A

Drugs & Therapeutics for Transverse Colon Cancer

Drugs for Transverse Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3 51-21-8 3385
2 Antimetabolites Phase 3
3 Antimetabolites, Antineoplastic Phase 3
4 Immunosuppressive Agents Phase 3
5 Cola Nutraceutical Phase 2, Phase 3, Early Phase 1
6
Bisacodyl Approved Phase 2 603-50-9
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
8
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
9
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
10 Orange Approved, Nutraceutical Phase 2
11
Pancrelipase Approved 53608-75-6
12
Glucosamine Approved, Nutraceutical 3416-24-8 439213
13 pancreatin
14 Anticoagulants
15 Fibrinolytic Agents
16 Glucuronyl glucosamine glycan sulfate
17 Hypoglycemic Agents
18 Hypolipidemic Agents
19 Lipid Regulating Agents

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 SLN in Colon Cancer Using a Multimodal Tracer Completed NCT02850783 Phase 2, Phase 3
2 Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety Active, not recruiting NCT01465451 Phase 3 intra-operative 5-FU chemotherapy
3 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2
4 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
5 Total/Subtotal Colectomy in Ovarian Cancer Recruiting NCT02595021 Phase 2
6 Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers Active, not recruiting NCT01950403 Phase 1 linaclotide acetate
7 Positioning During Colonoscopy Completed NCT01254435 Early Phase 1
8 Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON) Recruiting NCT03200834
9 Comparison of Limb Size of Transverse Coloplasty Pouch Recruiting NCT01071824
10 Investigate the Radical Extent of Lymphadenectomy of LAparoscopic Right Colectomy for Colon Cancer(RELARC). Recruiting NCT02619942
11 Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy. Recruiting NCT03045107
12 Impact of Additional DJ (Duodenojejunostomy)-Pexy on Reduction in Delayed Gastric Emptying Following Pylorus-preserving Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial Recruiting NCT02635399
13 A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440
14 Standardization of Laparoscopic Surgery for Right Hemi Colon Cancer (SLRC) Not yet recruiting NCT02942238

Search NIH Clinical Center for Transverse Colon Cancer

Genetic Tests for Transverse Colon Cancer

Anatomical Context for Transverse Colon Cancer

MalaCards organs/tissues related to Transverse Colon Cancer:

39
Colon, Lymph Node, Pancreas, Liver, Bone, Bone Marrow, Ovary

Publications for Transverse Colon Cancer

Articles related to Transverse Colon Cancer:

(show all 50)
id Title Authors Year
1
Comparison of short-term outcomes between laparoscopic-assisted and open complete mesocolic excision (CME) for the treatment of transverse colon cancer. ( 28285536 )
2017
2
Laparoscopic Colectomy Versus Open Colectomy for Treatment of Transverse Colon Cancer: A Systematic Review and Meta-Analysis. ( 28355104 )
2017
3
Laparoscopic vs open approach for transverse colon cancer. A systematic review and meta-analysis of short and long term outcomes. ( 28344158 )
2017
4
A comparison of laparoscopic and open D3 lymphadenectomy for transverse colon cancer. ( 28879395 )
2017
5
Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report. ( 28693131 )
2017
6
Spontaneous regression of transverse colon cancer: a case report. ( 28488173 )
2017
7
Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer. ( 27182170 )
2016
8
Laparoscopic complete mesocolic excision via combined medial and cranial approaches for transverse colon cancer. ( 27566603 )
2016
9
Delayed cecal perforation after successful colonic metal stenting in a patient with transverse colon cancer. ( 27059038 )
2016
10
Perioperative and short-term oncological outcomes of single-port surgery for transverse colon cancer. ( 27699489 )
2016
11
Perforated Transverse Colon Cancer Presenting as an Incarcerated Inguinal Hernia. ( 28877795 )
2016
12
Laparoscopic Complete Mesocolic Excision versus Open Complete Mesocolic Excision for Transverse Colon Cancer: Long-Term Survival Results of a Prospective Single Centre Non-Randomized Study. ( 26734758 )
2016
13
Short- and long-term outcomes of laparoscopic surgery vs open surgery for transverse colon cancer: a retrospective multicenter study. ( 27143915 )
2016
14
Perforated Transverse Colon Cancer Presenting as an Incarcerated Inguinal Hernia. ( 28206924 )
2016
15
Laparoscopic resection of transverse colon cancer at splenic flexure: technical aspects and results. ( 27015933 )
2016
16
Hematochezia due to Caecal Angiodysplazia led to Diagnosis of a Transverse Colon Cancer in a Young Female Patient: Case Report and Literature Review. ( 26305206 )
2015
17
Preoperative assessment of vascular anatomy by multidetector computed tomography before laparoscopic colectomy for transverse colon cancer: report of a case. ( 25692419 )
2015
18
Initial experience of robotic versus laparoscopic colectomy for transverse colon cancer: a matched case-control study. ( 26452727 )
2015
19
Ten-millimeter advanced transverse colon cancer accompanied by a sessile serrated adenoma and/or polyp. ( 25892059 )
2015
20
Robotic transverse colectomy for mid-transverse colon cancer: surgical techniques and oncologic outcomes. ( 26531113 )
2015
21
Transverse colon cancer occurring at a colostomy site 35 years after colostomy: a case report. ( 25943390 )
2015
22
Laparoscopic colectomy for transverse colon cancer: comparative analysis of short- and long-term outcomes. ( 26629108 )
2015
23
Bullous pemphigoid with IgG autoantibodies to BP180 C-terminal domain and desmocollin 3 associated with transverse colon cancer. ( 26693637 )
2015
24
Laparoscopic Surgery for Transverse Colon Cancer: Short- and Long-Term Outcomes in Comparison with Conventional Open Surgery. ( 26583447 )
2015
25
Outcome of Laparoscopic Versus Open Resection for Transverse Colon Cancer. ( 26197767 )
2015
26
Metastatic mucinous adenocarcinoma of the distal common bile duct, from transverse colon cancer presenting as obstructive jaundice. ( 26379735 )
2015
27
Comparison of long-term follow up of laparoscopic versus open colectomy for transverse colon cancer. ( 26130871 )
2015
28
Long-term outcomes of laparoscopic surgery for advanced transverse colon cancer. ( 24449001 )
2014
29
Laparoscopic versus open resection for transverse colon cancer. ( 25303924 )
2014
30
A Report of Disseminated Carcinomatosis of the Bone Marrow Originating from Transverse Colon Cancer Successfully Treated with Chemotherapy Using XELOX plus Bevacizumab. ( 25126072 )
2014
31
Transverse colon cancer presenting as acute abdominal wall abscess. ( 24798363 )
2014
32
Gastrocolic fistula secondary to transverse colon cancer. ( 24717990 )
2014
33
Comparative study of oncologic outcomes for laparoscopic vs. open surgery in transverse colon cancer. ( 24761404 )
2014
34
The transverse colon cancer with the reversed rotation of the midgut treated with single incision laparoscopic colectomy. ( 24426562 )
2013
35
Invasive adenocarcinoma arising from a mixed hyperplastic/adenomatous polyp and synchronous transverse colon cancer. ( 23984814 )
2013
36
Laparoscopic colectomy for transverse colon cancer in an automated peritoneal dialysis patient: A case report. ( 23706995 )
2013
37
A long adult intussusception secondary to transverse colon cancer. ( 23801849 )
2013
38
Short- and long-term results of laparoscopic surgery for transverse colon cancer. ( 23934542 )
2013
39
A new approach to laparoscopic lymph node excision in cases of transverse colon cancer. ( 22269292 )
2012
40
Laparoscopic resection of transverse colon cancer: long-term oncologic outcomes in 58 patients. ( 22690652 )
2012
41
Curative resection of transverse colon cancer via minilaparotomy. ( 21675613 )
2011
42
Surgical resection of locally advanced primary transverse colon cancer--not a worse outcome in stage II tumor. ( 21279365 )
2011
43
Short-term outcomes of laparoscopic colectomy for transverse colon cancer. ( 20224982 )
2010
44
Left paraduodenal hernia incidentally diagnosed during operation for transverse colon cancer. ( 20453424 )
2010
45
Hybrid hand-assisted colectomy for transverse colon cancer: a useful technique for non-expert laparoscopic surgeons. ( 19823906 )
2009
46
A comparative study on the short-term clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer. ( 19263150 )
2009
47
Surgical and pathological outcomes of laparoscopic surgery for transverse colon cancer. ( 18379794 )
2008
48
Successful simultaneous operation of concomitant early gastric cancer, transverse colon cancer, and a common iliac artery aneurysm. ( 10483757 )
1999
49
A case of transverse colon cancer secondarily involving the liver, duodenum, and pancreas. ( 8680119 )
1996
50
Gastrocolic fistula originating from transverse colon cancer: report of a case and review of the Japanese literature. ( 7780232 )
1994

Variations for Transverse Colon Cancer

Expression for Transverse Colon Cancer

Search GEO for disease gene expression data for Transverse Colon Cancer.

Pathways for Transverse Colon Cancer

GO Terms for Transverse Colon Cancer

Cellular components related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
2 mismatch repair complex GO:0032300 8.96 MSH2 PMS2
3 MutSalpha complex GO:0032301 8.62 MSH2 MSH6
4 plasma membrane GO:0005886 10.03 CD6 CEACAM5 COL17A1 DSC2 DSC3 GNAS

Biological processes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.84 CEACAM5 HRAS KRAS THBD
2 keratinization GO:0031424 9.83 DSC2 DSC3 KRT20 KRT7
3 female pregnancy GO:0007565 9.75 GNAS KRAS THBD
4 epidermal growth factor receptor signaling pathway GO:0007173 9.69 HRAS KRAS PIK3C2A
5 cornification GO:0070268 9.67 DSC2 DSC3 KRT20 KRT7
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 MLH1 MSH2 MSH6
7 determination of adult lifespan GO:0008340 9.57 MSH2 MSH6
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.56 MLH1 MSH2
9 response to isolation stress GO:0035900 9.55 HRAS KRAS
10 negative regulation of DNA recombination GO:0045910 9.49 MSH2 MSH6
11 positive regulation of helicase activity GO:0051096 9.48 MSH2 MSH6
12 mismatch repair GO:0006298 9.46 MLH1 MSH2 MSH6 PMS2
13 maintenance of DNA repeat elements GO:0043570 9.43 MSH2 MSH6
14 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
15 positive regulation of isotype switching to IgA isotypes GO:0048298 9.4 MLH1 MSH2
16 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
17 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MLH1 MSH2 MSH6
18 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.73 MLH1 MSH2 MSH6 PMS2
2 single-stranded DNA binding GO:0003697 9.63 MLH1 MSH2 PMS2
3 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
4 MutLalpha complex binding GO:0032405 9.4 MSH2 MSH6
5 oxidized purine DNA binding GO:0032357 9.37 MSH2 MSH6
6 MutSalpha complex binding GO:0032407 9.32 MLH1 PMS2
7 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
8 single thymine insertion binding GO:0032143 9.16 MSH2 MSH6
9 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
10 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Transverse Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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