MCID: TRN003
MIFTS: 44

Transverse Colon Cancer malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Transverse Colon Cancer

Aliases & Descriptions for Transverse Colon Cancer:

Name: Transverse Colon Cancer 12 14
Malignant Neoplasm of Transverse Colon 69
Malignant Tumor of Transverse Colon 12
Ca Transverse Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:261
ICD10 33 C18.4
ICD9CM 35 153.1
UMLS 69 C0153434

Summaries for Transverse Colon Cancer

MalaCards based summary : Transverse Colon Cancer, also known as malignant neoplasm of transverse colon, is related to herpes zoster and cask-related disorders. An important gene associated with Transverse Colon Cancer is ETFA (Electron Transfer Flavoprotein Alpha Subunit), and among its related pathways/superpathways are Keratinization and Pathways in cancer. The drugs Fluorouracil and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and liver, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Related Diseases for Transverse Colon Cancer

Diseases related to Transverse Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 herpes zoster 10.2 COL17A1 DSC2 DSC3
2 cask-related disorders 10.2 MSH6 PMS2
3 folinic acid-responsive seizures 10.2 COL17A1 DSC2 DSC3
4 neurocutaneous melanosis, somatic 10.2 HRAS MLH1 MSH2
5 benign fibrous mesothelioma 10.2 MLH1 MSH2 MSH6
6 pelvic inflammatory disease 10.2 HRAS KRAS KRT20
7 allergic contact dermatitis 10.2 KRAS KRT20 MLH1
8 tabes dorsalis 10.2 HRAS KRAS KRT20
9 large cell neuroendocrine carcinoma 10.2 GNAS KRAS KRT20
10 congenital symblepharon 10.1 HRAS KRAS MLH1 MSH2
11 asperger syndrome 10.1 MLH1 MSH2 MSH6
12 large intestine adenoma 10.1 MLH1 MSH2 MSH6 PMS2
13 neuropathy, distal hereditary motor, type viib 10.1 MLH1 MSH2 MSH6 PMS2
14 cauda equina neoplasm 10.1 MLH1 MSH2 MSH6 PMS2
15 neurofibromatosis-noonan syndrome 10.1 MLH1 MSH2 MSH6 PMS2
16 mismatch repair cancer syndrome 10.1 MLH1 MSH2 MSH6 PMS2
17 fibromatosis, gingival, 1 10.1 MLH1 MSH2 MSH6 PMS2
18 autosomal genetic disease 10.1 MLH1 MSH2 MSH6 PMS2
19 t-cell large granular lymphocyte leukemia 10.1 MLH1 MSH2 MSH6 PMS2
20 malignant skin fibrous histiocytoma 10.1 CEACAM5 HRAS KRAS
21 precursor t-lymphoblastic lymphoma/leukemia 10.1 CEACAM5 HRAS KRAS
22 breast mucinous cystadenocarcinoma 10.1 CEACAM5 HRAS KRAS
23 radiculopathy 10.0 KRT20 KRT7
24 adult myxoid chondrosarcoma 10.0 KRT20 KRT7
25 hnrnpa1-related amyotrophic lateral sclerosis 10.0 KRAS MLH1 MSH2 MSH6 PMS2
26 paroxysmal nocturnal hemoglobinuria 10.0 CEACAM5 HRAS KRAS
27 hidradenoma 10.0 KRAS MLH1 MSH2 MSH6 PMS2
28 neuroretinitis 10.0 KRAS KRT20 MLH1 MSH2 MSH6
29 bronchus mucoepidermoid carcinoma 10.0 KRT20 KRT7
30 seborrheic dermatitis 10.0 HRAS MLH1 MSH2 MSH6 PMS2
31 postpoliomyelitis syndrome 10.0 HRAS KRAS KRT7
32 agenesis and aplasia of uterine body 10.0 KRAS KRT20 KRT7
33 peritoneal benign neoplasm 10.0 KRT20 KRT7
34 sphenoid sinus squamous cell carcinoma 10.0 CEACAM5 KRT20 THBD
35 skin papilloma 10.0 HRAS KRT20 MLH1 MSH2 MSH6
36 bilateral hypoactive labyrinth 10.0 HRAS KRAS KRT7
37 steroid-induced glaucoma - borderline 10.0 KRT20 KRT7
38 cranial nerve disease 10.0 CEACAM5 KRT20 THBD
39 sagittal sinus thrombosis 10.0 KRAS KRT20 KRT7
40 non specific chronic endometritis 10.0 KRT20 KRT7
41 cervical serous adenocarcinoma 10.0 CEACAM5 GNAS HRAS KRAS
42 monoclonal paraproteinemia 10.0 CEACAM5 KRAS KRT20 MLH1
43 bardet-biedl syndrome 9.9 CEACAM5 MLH1 MSH2 MSH6
44 dystonia 9.9 KRT20 KRT7
45 mucosal melanoma 9.9 KRT20 KRT7 MSH6
46 alpha chain disease 9.9 HRAS KRT20 KRT7
47 anal canal paget's disease 9.9 KRT20 KRT7
48 deep angioma 9.9 CEACAM5 KRT7
49 ideomotor apraxia 9.9 CEACAM5 HRAS KRAS MLH1 MSH2
50 osteosarcoma arising in bone paget's disease 9.9 CEACAM5 KRT7

Comorbidity relations with Transverse Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Transverse Colon Cancer:



Diseases related to Transverse Colon Cancer

Symptoms & Phenotypes for Transverse Colon Cancer

GenomeRNAi Phenotypes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.17 DSC3 KRAS MLH1 MSH6 PIK3C2A PMS2

MGI Mouse Phenotypes related to Transverse Colon Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 CYP27A1 EPB41L5 GNAS HCK HRAS KRAS
2 cardiovascular system MP:0005385 10.06 CYP27A1 DSC2 EPB41L5 GNAS HCK HRAS
3 mortality/aging MP:0010768 9.93 DSC3 EPB41L5 GNAS HCK HRAS KRAS
4 digestive/alimentary MP:0005381 9.91 CYP27A1 EPB41L5 KRAS MLH1 MSH2 PMS2
5 integument MP:0010771 9.86 DSC3 GNAS HRAS KRAS MLH1 MSH2
6 neoplasm MP:0002006 9.56 GNAS HCK HRAS KRAS MLH1 MSH2
7 renal/urinary system MP:0005367 9.17 CYP27A1 GNAS HRAS KRAS KRT7 PIK3C2A

Drugs & Therapeutics for Transverse Colon Cancer

Drugs for Transverse Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3 51-21-8 3385
2 Antimetabolites Phase 3
3 Antimetabolites, Antineoplastic Phase 3
4 Immunosuppressive Agents Phase 3
5 Cola Nutraceutical Phase 2, Phase 3, Early Phase 1
6
Bisacodyl Approved Phase 2 603-50-9
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
8
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
9
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
10 Orange Nutraceutical Phase 2
11
Coal tar Approved 8007-45-2
12
Pancrelipase Approved 53608-75-6
13
Glucosamine Approved, Nutraceutical 3416-24-8 439213
14 Anesthetics
15 pancreatin
16 Anticoagulants
17 Fibrinolytic Agents
18 Glucuronyl glucosamine glycan sulfate
19 Hypoglycemic Agents
20 Hypolipidemic Agents
21 Lipid Regulating Agents

Interventional clinical trials:

(show all 23)
id Name Status NCT ID Phase
1 SLN in Colon Cancer Using a Multimodal Tracer Completed NCT02850783 Phase 2, Phase 3
2 Study of Two Techniques of Rectal Reservoir in Low Anterior Resection of Rectum Completed NCT01396928 Phase 2, Phase 3
3 Intra-operative Chemotherapy With 5-FU for Colorectal Cancer Patients Receiving Curative Resection: Efficacy and Safety Active, not recruiting NCT01465451 Phase 3
4 Short Term Outcomes of Laparoscopic Intersphincteric Resection for Low Rectal Cancer Active, not recruiting NCT01836926 Phase 2, Phase 3
5 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
6 Total/Subtotal Colectomy in Ovarian Cancer Recruiting NCT02595021 Phase 2
7 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Active, not recruiting NCT01861691 Phase 2
8 Local Ablative Strategies After Endovascular Radioembolization Recruiting NCT02611661 Phase 1
9 Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers Active, not recruiting NCT01950403 Phase 1
10 Comparison of Limb Size of Transverse Coloplasty Pouch Unknown status NCT01071824
11 INtracorporeal Versus EXTracorpoREal anastoMOsis After Laparoscopic Right Colectomy for Cancer Unknown status NCT01679756
12 Positioning During Colonoscopy Completed NCT01254435 Early Phase 1
13 Omentectomy and Metabolic Syndrome Completed NCT00923260
14 Dynamic Position Change in Colonic Adenoma Detection Completed NCT01366079
15 Advanced Metagenomic Analysis of Human Colonic Microbiota in Patients With Chronic GI Disorders Completed NCT01099111
16 Retroview Colonoscope for the Evaluation of Colon Mucosa Study Completed NCT02352233
17 Investigate the Radical Extent of Lymphadenectomy of LAparoscopic Right Colectomy for Colon Cancer(RELARC). Recruiting NCT02619942
18 Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy. Recruiting NCT03045107
19 Impact of Additional DJ (Duodenojejunostomy)-Pexy on Reduction in Delayed Gastric Emptying Following Pylorus-preserving Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial Recruiting NCT02635399
20 A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440
21 Feasibility and Effectiveness of Colonic Irrigation Active, not recruiting NCT02826967
22 A Study Between Two Instrument Generations to Improve Adenoma Detection in Screening Colonoscopy Active, not recruiting NCT03137277
23 Standardization of Laparoscopic Surgery for Right Hemi Colon Cancer (SLRC) Not yet recruiting NCT02942238

Search NIH Clinical Center for Transverse Colon Cancer

Genetic Tests for Transverse Colon Cancer

Anatomical Context for Transverse Colon Cancer

MalaCards organs/tissues related to Transverse Colon Cancer:

39
Colon, Bone, Liver, Bone Marrow, Lymph Node, Pancreas

Publications for Transverse Colon Cancer

Articles related to Transverse Colon Cancer:

(show all 42)
id Title Authors Year
1
Delayed cecal perforation after successful colonic metal stenting in a patient with transverse colon cancer. ( 27059038 )
2016
2
Short- and long-term outcomes of laparoscopic surgery vs open surgery for transverse colon cancer: a retrospective multicenter study. ( 27143915 )
2016
3
Laparoscopic resection of transverse colon cancer at splenic flexure: technical aspects and results. ( 27015933 )
2016
4
Perioperative and short-term oncological outcomes of single-port surgery for transverse colon cancer. ( 27699489 )
2016
5
Pseudo-Meigs' syndrome secondary to metachronous ovarian metastases from transverse colon cancer. ( 27182170 )
2016
6
Laparoscopic Complete Mesocolic Excision versus Open Complete Mesocolic Excision for Transverse Colon Cancer: Long-Term Survival Results of a Prospective Single Centre Non-Randomized Study. ( 26734758 )
2016
7
Laparoscopic complete mesocolic excision via combined medial and cranial approaches for transverse colon cancer. ( 27566603 )
2016
8
Bullous pemphigoid with IgG autoantibodies to BP180 C-terminal domain and desmocollin 3 associated with transverse colon cancer. ( 26693637 )
2015
9
Robotic transverse colectomy for mid-transverse colon cancer: surgical techniques and oncologic outcomes. ( 26531113 )
2015
10
Initial experience of robotic versus laparoscopic colectomy for transverse colon cancer: a matched case-control study. ( 26452727 )
2015
11
Ten-millimeter advanced transverse colon cancer accompanied by a sessile serrated adenoma and/or polyp. ( 25892059 )
2015
12
Comparison of long-term follow up of laparoscopic versus open colectomy for transverse colon cancer. ( 26130871 )
2015
13
Outcome of Laparoscopic Versus Open Resection for Transverse Colon Cancer. ( 26197767 )
2015
14
Transverse colon cancer occurring at a colostomy site 35 years after colostomy: a case report. ( 25943390 )
2015
15
Laparoscopic Surgery for Transverse Colon Cancer: Short- and Long-Term Outcomes in Comparison with Conventional Open Surgery. ( 26583447 )
2015
16
Hematochezia due to Caecal Angiodysplazia led to Diagnosis of a Transverse Colon Cancer in a Young Female Patient: Case Report and Literature Review. ( 26305206 )
2015
17
Preoperative assessment of vascular anatomy by multidetector computed tomography before laparoscopic colectomy for transverse colon cancer: report of a case. ( 25692419 )
2015
18
Metastatic mucinous adenocarcinoma of the distal common bile duct, from transverse colon cancer presenting as obstructive jaundice. ( 26379735 )
2015
19
Laparoscopic colectomy for transverse colon cancer: comparative analysis of short- and long-term outcomes. ( 26629108 )
2015
20
Laparoscopic versus open resection for transverse colon cancer. ( 25303924 )
2014
21
Long-term outcomes of laparoscopic surgery for advanced transverse colon cancer. ( 24449001 )
2014
22
Comparative study of oncologic outcomes for laparoscopic vs. open surgery in transverse colon cancer. ( 24761404 )
2014
23
A Report of Disseminated Carcinomatosis of the Bone Marrow Originating from Transverse Colon Cancer Successfully Treated with Chemotherapy Using XELOX plus Bevacizumab. ( 25126072 )
2014
24
Transverse colon cancer presenting as acute abdominal wall abscess. ( 24798363 )
2014
25
Gastrocolic fistula secondary to transverse colon cancer. ( 24717990 )
2014
26
Invasive adenocarcinoma arising from a mixed hyperplastic/adenomatous polyp and synchronous transverse colon cancer. ( 23984814 )
2013
27
A long adult intussusception secondary to transverse colon cancer. ( 23801849 )
2013
28
The transverse colon cancer with the reversed rotation of the midgut treated with single incision laparoscopic colectomy. ( 24426562 )
2013
29
Short- and long-term results of laparoscopic surgery for transverse colon cancer. ( 23934542 )
2013
30
Laparoscopic colectomy for transverse colon cancer in an automated peritoneal dialysis patient: A case report. ( 23706995 )
2013
31
Laparoscopic resection of transverse colon cancer: long-term oncologic outcomes in 58 patients. ( 22690652 )
2012
32
A new approach to laparoscopic lymph node excision in cases of transverse colon cancer. ( 22269292 )
2012
33
Surgical resection of locally advanced primary transverse colon cancer--not a worse outcome in stage II tumor. ( 21279365 )
2011
34
Curative resection of transverse colon cancer via minilaparotomy. ( 21675613 )
2011
35
Short-term outcomes of laparoscopic colectomy for transverse colon cancer. ( 20224982 )
2010
36
Left paraduodenal hernia incidentally diagnosed during operation for transverse colon cancer. ( 20453424 )
2010
37
Hybrid hand-assisted colectomy for transverse colon cancer: a useful technique for non-expert laparoscopic surgeons. ( 19823906 )
2009
38
A comparative study on the short-term clinicopathologic outcomes of laparoscopic surgery versus conventional open surgery for transverse colon cancer. ( 19263150 )
2009
39
Surgical and pathological outcomes of laparoscopic surgery for transverse colon cancer. ( 18379794 )
2008
40
Successful simultaneous operation of concomitant early gastric cancer, transverse colon cancer, and a common iliac artery aneurysm. ( 10483757 )
1999
41
A case of transverse colon cancer secondarily involving the liver, duodenum, and pancreas. ( 8680119 )
1996
42
Gastrocolic fistula originating from transverse colon cancer: report of a case and review of the Japanese literature. ( 7780232 )
1994

Variations for Transverse Colon Cancer

Expression for Transverse Colon Cancer

Search GEO for disease gene expression data for Transverse Colon Cancer.

Pathways for Transverse Colon Cancer

GO Terms for Transverse Colon Cancer

Cellular components related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
2 mismatch repair complex GO:0032300 8.96 MSH2 PMS2
3 MutSalpha complex GO:0032301 8.62 MSH2 MSH6
4 plasma membrane GO:0005886 10.03 CEACAM5 COL17A1 DSC2 DSC3 EPB41L5 GNAS

Biological processes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.84 CEACAM5 HRAS KRAS THBD
2 keratinization GO:0031424 9.83 DSC2 DSC3 KRT20 KRT7
3 female pregnancy GO:0007565 9.75 GNAS KRAS THBD
4 epidermal growth factor receptor signaling pathway GO:0007173 9.69 HRAS KRAS PIK3C2A
5 cornification GO:0070268 9.67 DSC2 DSC3 KRT20 KRT7
6 positive regulation of actin cytoskeleton reorganization GO:2000251 9.58 HCK HRAS
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MLH1 MSH2 MSH6
8 determination of adult lifespan GO:0008340 9.57 MSH2 MSH6
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.56 MLH1 MSH2
10 response to isolation stress GO:0035900 9.55 HRAS KRAS
11 negative regulation of DNA recombination GO:0045910 9.49 MSH2 MSH6
12 positive regulation of helicase activity GO:0051096 9.48 MSH2 MSH6
13 maintenance of DNA repeat elements GO:0043570 9.46 MSH2 MSH6
14 mismatch repair GO:0006298 9.46 MLH1 MSH2 MSH6 PMS2
15 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MLH1 MSH2
16 isotype switching GO:0045190 9.43 MLH1 MSH2 MSH6
17 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
18 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MLH1 MSH2 MSH6
19 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.71 MLH1 MSH2 MSH6 PMS2
2 single-stranded DNA binding GO:0003697 9.63 MLH1 MSH2 PMS2
3 four-way junction DNA binding GO:0000400 9.48 MSH2 MSH6
4 oxidized purine DNA binding GO:0032357 9.43 MSH2 MSH6
5 MutLalpha complex binding GO:0032405 9.37 MSH2 MSH6
6 MutSalpha complex binding GO:0032407 9.32 MLH1 PMS2
7 single guanine insertion binding GO:0032142 9.26 MSH2 MSH6
8 single thymine insertion binding GO:0032143 9.16 MSH2 MSH6
9 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
10 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2

Sources for Transverse Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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