MCID: TRN034
MIFTS: 48

Transverse Myelitis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Transverse Myelitis

MalaCards integrated aliases for Transverse Myelitis:

Name: Transverse Myelitis 50 51
Myelitis, Transverse 69
Myelitis Transverse 52

Classifications:



Summaries for Transverse Myelitis

NINDS : 51 Transverse myelitis is an inflammation of the spinal cord. The inflammation interrupts communications between nerve fibers in the spinal cord and the rest of the body, affectng sensation and nerve signaling below the damage to the protective nerve coating called myelin. The segment of the spinal cord at which the damage occurs determines which parts of the body are affected. Damage at one segment will affect function at that level and below. In people with transverse myelitis, the myelin damage most often occurs in neres in the upper back, causing problems with leg movement and bowel and bladder control, which require signals from the lower segments of the spinal cord.  Classic symptoms include weakness of the arms and legs; sensory alterations such as burning, pricking, numbness, or sensory loss;  pain (usually in the lower back or down the legs and arms or around the torso); and bowel and bladder dysfunction. Symptoms may develop suddenly or over days or weeks. Some cases of transverse myelitis occur on their own, but a number of conditions appear to cause the disorder, including immune system disorders, bacteial and viral infections, fungal infections, and various parasites.  Transverse myelitis can affect people of any age, but a peak in incidence rates appears to occur between 10 and 19 years of age and 30 to 39 years of age.

MalaCards based summary : Transverse Myelitis, also known as myelitis, transverse, is related to myelitis and systemic lupus erythematosus. An important gene associated with Transverse Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Interferon beta-1a and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

NIH Rare Diseases : 50 transverse myelitis is a neurological disorder caused by inflammation across both sides of one level, or segment, of the spinal cord. the term myelitis refers to inflammation of the spinal cord; transverse describes the position of the inflammation, that is, across the width of the spinal cord. attacks of inflammation can damage or destroy myelin, the fatty insulating substance that covers nerve cell fibers. this damage causes nervous system scars that interrupt communications between the nerves in the spinal cord and the rest of the body. transverse myelitis is part of a spectrum of neuroimmunologic diseases of the central nervous system. other disorders in this spectrum include, acute disseminated encephalomyelitis (adem), optic neuritis, and neuromyelitis optica (devic's disease). last updated: 9/2/2015

Wikipedia : 72 Transverse myelitis is a neurological condition in which the spinal cord is inflamed. The inflammation... more...

Related Diseases for Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 377)
id Related Disease Score Top Affiliating Genes
1 myelitis 33.0 IL10 IL6 MMP9
2 systemic lupus erythematosus 31.4 APOH IL10 IL17A IL6 TNF
3 primary biliary cirrhosis 30.2 IL10 IL6 TNF
4 intracranial hypertension 29.9 CXCL8 IL10 IL17A
5 melioidosis 29.7 IL10 IL6 TNF
6 hepatitis b 29.3 CD27 CXCL8 IL10 TNF
7 lymphoma 29.3 APOH IL10 IL17A IL6 TNF
8 rheumatoid arthritis 28.8 CXCL8 IL10 IL17A IL6 TNF
9 ulcerative colitis 28.6 AQP4 IL10 IL6 MBP TNF
10 acute transverse myelitis 12.3
11 idiopathic acute transverse myelitis 12.3
12 secondary acute transverse myelitis 12.2
13 neuromyelitis optica 11.5
14 antiphospholipid syndrome 11.4
15 thyrotoxic periodic paralysis 11.0
16 lupus - neurological sequelae 11.0
17 paresthesia 11.0
18 asphyxia neonatorum 10.7 APOH IL6
19 peroneal nerve paralysis 10.7 IL10 IL6
20 facial arteriovenous malformation 10.7 MMP2 MMP9
21 neutrophil-specific granule deficiency 10.7 IL10 IL17A
22 oculomotor nerve paralysis 10.7 CXCL8 IL6
23 familial short qt syndrome 10.7 MMP2 MMP9
24 common peroneal nerve lesion 10.6 CXCL8 IL6
25 kleptomania 10.6 MMP2 MMP9
26 leucocyte adhesion defect 10.6 MMP2 MMP9
27 acquired hemangioma 10.6 MMP2 MMP9
28 transitional meningioma 10.6 MMP2 MMP9
29 neonatal marfan syndrome 10.6 CXCL8 IL17A
30 tinea profunda 10.5 MMP2 MMP9
31 ichthyosis, congenital, autosomal recessive 12 10.5 CXCL8 MMP9
32 lymph node palisaded myofibroblastoma 10.5 CXCL8 IL10
33 xanthogranulomatous cholecystitis 10.5 MMP2 MMP9
34 schwannoma of ureter 10.5 CXCL8 IL6
35 congenital insensitivity to pain with hyperhidrosis 10.5 CXCL8 IL10
36 psychotic disorder 10.5 CXCL8 IL6
37 cogan-reese syndrome 10.5 AQP4 MBP
38 hypersplenism 10.5 AQP4 MBP
39 smarca4-deficient sarcoma of thorax 10.5 IL6 TNF
40 calciphylaxis 10.5 AQP4 IL6 MMP9
41 hidradenitis suppurativa 10.5 CXCL8 IL10
42 nonspecific interstitial pneumonia 10.5 CXCL8 IL10
43 vulvar nodular hidradenoma 10.5 IL10 IL17A IL6
44 collagenous colitis 10.5 APOH MMP2 MMP9
45 lupus erythematosus 10.4
46 cecum adenoma 10.4 IL17A MMP2 MMP9
47 aortic arch interruption 10.4 IL6 TNF
48 mastoiditis 10.4 IL6 MMP2 MMP9
49 necrotic uveal melanoma 10.4 APOH CXCL8 IL6
50 pure autonomic failure 10.4 IL10 TNF

Graphical network of the top 20 diseases related to Transverse Myelitis:



Diseases related to Transverse Myelitis

Symptoms & Phenotypes for Transverse Myelitis

GenomeRNAi Phenotypes related to Transverse Myelitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 APOH CXCL8 IL10 IL17A TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 APOH CD27 CXCL8 IL10 IL17A TNF

MGI Mouse Phenotypes related to Transverse Myelitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 MMP9 IL17A IL6 AQP4 MBP CD27
2 homeostasis/metabolism MP:0005376 10.02 MMP9 IL17A APOA1 APOH IL6 AQP4
3 endocrine/exocrine gland MP:0005379 9.95 IL10 AMPH IL17A APOA1 IL6 AQP4
4 digestive/alimentary MP:0005381 9.91 IL17A IL6 AQP4 MMP9 TNF IL10
5 immune system MP:0005387 9.91 MMP9 IL17A IL6 AQP4 MBP CD27
6 mortality/aging MP:0010768 9.85 MMP9 IL17A AMPH APOH IL6 AQP4
7 respiratory system MP:0005388 9.5 IL17A IL6 AQP4 TNF MMP2 IL10
8 vision/eye MP:0005391 9.17 MMP9 IL6 AQP4 MBP TNF MMP2

Drugs & Therapeutics for Transverse Myelitis

Drugs for Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
2 Adjuvants, Immunologic Phase 4
3 Anti-Infective Agents Phase 4
4 Antiviral Agents Phase 4
5 Interferon-beta Phase 4
6 interferons Phase 4
7
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 3,Phase 1 50-24-8 5755
9 Antiemetics Phase 3,Phase 1
10 Anti-Inflammatory Agents Phase 3,Phase 1
11 Autonomic Agents Phase 3,Phase 1
12 Gastrointestinal Agents Phase 3,Phase 1
13 glucocorticoids Phase 3,Phase 1
14 Hormone Antagonists Phase 3,Phase 1
15 Hormones Phase 3,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
17 Methylprednisolone acetate Phase 3,Phase 1
18 Methylprednisolone Hemisuccinate Phase 3,Phase 1
19 Neuroprotective Agents Phase 3,Phase 1
20 Peripheral Nervous System Agents Phase 3,Phase 1
21 Prednisolone acetate Phase 3,Phase 1
22 Prednisolone hemisuccinate Phase 3,Phase 1
23 Prednisolone phosphate Phase 3,Phase 1
24 Protective Agents Phase 3,Phase 1
25 Antineoplastic Agents, Hormonal Phase 3,Phase 1
26 Antibodies Phase 3,Phase 1
27 Immunoglobulins Phase 3,Phase 1
28 gamma-Globulins Phase 3
29 Immunoglobulins, Intravenous Phase 3
30 Rho(D) Immune Globulin Phase 3
31
4-Aminopyridine Approved Phase 2 504-24-5 1727
32 Immunosuppressive Agents Phase 1, Phase 2
33 Potassium Channel Blockers Phase 2
34
Protein C Approved Phase 1
35
rituximab Approved Phase 1 174722-31-7 10201696
36
Bevacizumab Approved, Investigational Phase 1 216974-75-3
37 Alpha 1-Antitrypsin Phase 1
38 HIV Protease Inhibitors Phase 1
39
protease inhibitors Phase 1
40 Protein C Inhibitor Phase 1
41 Serine Proteinase Inhibitors Phase 1
42 Trypsin Inhibitors Phase 1
43 Antirheumatic Agents Phase 1
44 Angiogenesis Inhibitors Phase 1
45 Angiogenesis Modulating Agents Phase 1
46 Complement C1 Inactivator Proteins Phase 1
47 Complement C1 Inhibitor Protein Phase 1
48 Complement C1s Phase 1
49 Complement Inactivating Agents Phase 1
50 Complement System Proteins Phase 1

Interventional clinical trials:

(show all 24)

id Name Status NCT ID Phase Drugs
1 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study) Active, not recruiting NCT01892345 Phase 3 Eculizumab
4 An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients Enrolling by invitation NCT02003144 Phase 3
5 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
6 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
7 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica Unknown status NCT01364246 Phase 1, Phase 2
8 Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) Active, not recruiting NCT02166346 Phase 2 Dalfampridine;Placebo
9 A Longitudinal Study of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active NMOSD Active, not recruiting NCT03062579 Phase 1, Phase 2 Tocilizumab
10 Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica Relapses Unknown status NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
11 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab
12 Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations Completed NCT01777412 Phase 1 Bevacizumab
13 C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
14 Central Pain Study for ABX-1431 Recruiting NCT03138421 Phase 1 ABX-1431 HCl;Placebo
15 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1 Ublituximab
16 Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct Unknown status NCT01024985
17 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
18 Clinical Trial of a Serious Game for Individuals With SCI/D Completed NCT02341950
19 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
20 The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
21 The French Cohort and Biobank of Devic's Neuromyelitis Optica and Related Neurological Disorders (NMOSD) (NOMADMUS) Recruiting NCT02850705
22 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
23 Maintenance Plasma Exchange for Neuromyelitis Optica Active, not recruiting NCT01500681
24 Serum Auto-Antibodies in Neurological Diseases Enrolling by invitation NCT00704626

Search NIH Clinical Center for Transverse Myelitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Transverse Myelitis

Anatomical Context for Transverse Myelitis

MalaCards organs/tissues related to Transverse Myelitis:

39
Spinal Cord, Brain, Bone Marrow, Thyroid, Lung, Kidney, B Cells

Publications for Transverse Myelitis

Articles related to Transverse Myelitis:

(show top 50) (show all 627)
id Title Authors Year
1
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
2
Refractory Longitudinally Extensive Transverse Myelitis Responsive to Cyclophosphamide. ( 28724464 )
2017
3
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
4
Comorbidity of narcolepsy with cataplexy and transverse myelitis: aA common autoimmune background? A case report. ( 28449899 )
2017
5
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
6
Longitudinally Extensive Transverse Myelitis and Optic Neuropathy Associated with Syphilitic Meningomyelitis and Human Immunodeficiency Virus Infection: A Case Report and Review of the Literature. ( 28768983 )
2017
7
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
8
Transverse myelitis as an unexpected complication following treatment with dinutuximab in pediatric patients with high-risk neuroblastoma: A case series. ( 28748630 )
2017
9
A multicentre randomiSed controlled TRial of IntraVEnous immunoglobulin compared with standard therapy for the treatment of transverse myelitis in adults and children (STRIVE). ( 28639937 )
2017
10
Acute paraparesis and sensory loss following intravenous corticosteroid administration in a case of longitudinally extensive transverse myelitis caused by spinal dural arteriovenous fistula: case report and review of literature. ( 28546874 )
2017
11
A Rare Infectious Cause of Transverse Myelitis. ( 28004628 )
2017
12
Case series of two patients with Fibrocartilaginous Embolism mimicking Transverse Myelitis of the Spinal Cord. ( 28246010 )
2017
13
Clinical outcomes and predictive factors related to good outcomes in plasma exchange in severe attack of NMOSD and long extensive transverse myelitis: Case series and review of the literature. ( 28427710 )
2017
14
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
15
Clinical commentary on 'Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder with recurrent short partial transverse myelitis and favorable prognosis: Two new cases', by Wang et al. ( 28580877 )
2017
16
Pediatric acute transverse myelitis. ( 28678221 )
2017
17
Cytomegalovirus-related transverse myelitis in an immunocompetent host: a subacute onset of an immune-mediated disease? ( 28801328 )
2017
18
Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder with recurrent short partial transverse myelitis and favorable prognosis: Two new cases. ( 28580873 )
2017
19
Subacute Progressive Myelopathy: Transverse Myelitis or Subacute Combined Degeneration? A Case Report. ( 28797832 )
2017
20
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
21
Chiari I malformation in children with transverse myelitis. ( 28537458 )
2017
22
Effect of Electroacupuncture Rehabilitation in Transverse Myelitis: A Case Report. ( 28889845 )
2017
23
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
24
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
25
Concomitant Transverse Myelitis and Acute Axonal Sensory-Motor Neuropathy in an Elderly Patient. ( 28785494 )
2017
26
A rare case of an 8-month-old child with dengue fever complicated by acute diffuse transverse myelitis. ( 27857814 )
2016
27
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
28
A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient. ( 27883372 )
2016
29
Poster 378 Transverse Myelitis Secondary to Infectious Mononucleosis: A Case Report. ( 27673130 )
2016
30
Longitudinally extensive transverse myelitis: A retrospective analysis of sixty-four patients at tertiary care center of North-West India. ( 27348743 )
2016
31
Transverse myelitis associated with heroin and cannabis abuse: a new issue from the past. ( 27003705 )
2016
32
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
33
Idiopathic Transverse Myelitis Mimicking an Intramedullary Spinal Cord Tumor. ( 27672469 )
2016
34
Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status. ( 27538606 )
2016
35
Parainfectious longitudinally extensive transverse myelitis associated with varicella-zoster virus. ( 27157526 )
2016
36
Transverse myelitis. ( 26882855 )
2016
37
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
38
Transverse Myelitis and Neuromyelitis Optica Spectrum Disorders. ( 27616312 )
2016
39
Linear lesions may assist early diagnosis of neuromyelitis optica and longitudinally extensive transverse myelitis, two subtypes of NMOSD. ( 26723980 )
2016
40
Pediatric transverse myelitis. ( 27572861 )
2016
41
Teaching NeuroImages: Longitudinally extensive transverse myelitis in MELAS. ( 26810428 )
2016
42
Concomitant Guillain Barre Syndrome and Transverse Myelitis as Initial Neuropsychiatric Manifestation in a Case of Lupus: A Diagnostic Quandary. ( 27242943 )
2016
43
Differentiation of neuromyelitis optica spectrum disorders from ultra-longitudinally extensive transverse myelitis in a cohort of Chinese patients. ( 26857502 )
2016
44
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
45
Longitudinal extensive transverse myelitis and Zika virus: A diagnostic challenge in a hospital in Colombia. ( 27776956 )
2016
46
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
47
Neuropathic pruritus as the p]resenting symptom of lupus transverse myelitis. ( 27538617 )
2016
48
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
49
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
50
Hemorrhagic Longitudinally Extensive Transverse Myelitis. ( 27847660 )
2016

Variations for Transverse Myelitis

Expression for Transverse Myelitis

Search GEO for disease gene expression data for Transverse Myelitis.

Pathways for Transverse Myelitis

Pathways related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 46)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 CD27 CXCL8 IL10 IL17A IL6 TNF
2
Show member pathways
13.27 CD27 CXCL8 IL10 IL17A IL6 MMP2
3
Show member pathways
13.22 CD27 CXCL8 IL10 IL17A IL6 TNF
4
Show member pathways
12.79 CXCL8 IL10 IL17A IL6 TNF
5 12.59 CXCL8 IL6 MMP2 MMP9
6
Show member pathways
12.55 IL10 IL17A IL6 MMP2 TNF
7
Show member pathways
12.53 IL10 IL17A IL6 TNF
8
Show member pathways
12.38 IL10 IL17A IL6 TNF
9
Show member pathways
12.28 CXCL8 IL17A IL6 MMP9 TNF
10 12.15 IL6 MMP2 MMP9 TNF
11 12.1 AQP4 CXCL8 IL10 IL6 TNF
12 12.02 MMP2 MMP9 TNF
13
Show member pathways
12.01 CXCL8 IL10 IL17A IL6 TNF
14 11.93 IL10 IL6 TNF
15
Show member pathways
11.93 IL10 IL17A IL6 TNF
16 11.89 IL6 MMP9 TNF
17 11.89 CXCL8 IL6 MMP2 TNF
18 11.87 CXCL8 IL10 IL6 TNF
19
Show member pathways
11.85 MMP2 MMP9 TNF
20 11.83 CXCL8 IL17A IL6 TNF
21
Show member pathways
11.82 CXCL8 IL17A IL6
22 11.75 IL10 IL17A TNF
23 11.74 CXCL8 MMP2 MMP9
24 11.72 IL10 IL6 TNF
25 11.72 CXCL8 IL10 IL6 TNF
26 11.7 CXCL8 MMP2 MMP9
27 11.68 IL10 IL6 TNF
28 11.64 CXCL8 IL6 MMP2 MMP9
29 11.61 CXCL8 MMP2 MMP9
30 11.56 CXCL8 IL6 MMP2
31 11.55 CXCL8 IL6 TNF
32 11.52 IL6 MMP2 TNF
33 11.51 AQP4 CXCL8 IL6 MBP MMP9 TNF
34 11.47 CXCL8 IL10 IL6 TNF
35 11.45 CXCL8 IL10 IL6 TNF
36 11.45 CXCL8 IL6 MMP2 MMP9 TNF
37 11.42 IL6 MMP2 MMP9 TNF
38
Show member pathways
11.35 CXCL8 IL6 MMP2 MMP9 TNF
39 11.34 IL10 IL6 TNF
40 11.29 IL17A IL6 TNF
41 11.26 IL10 IL6 TNF
42 11.22 CXCL8 IL10 IL17A IL6 MMP2 MMP9
43 11.21 APOA1 IL10 IL6 TNF
44 11.15 CXCL8 IL6 MMP2 MMP9
45 11.14 CXCL8 IL10 IL17A IL6 TNF
46 11.02 CXCL8 IL6 TNF

GO Terms for Transverse Myelitis

Cellular components related to Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 APOA1 APOH CXCL8 IL10 IL17A IL6
2 external side of plasma membrane GO:0009897 9.55 AQP4 CD27 IL17A IL6 TNF
3 extracellular matrix GO:0031012 9.43 APOH MMP2 MMP9
4 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOH
5 chylomicron GO:0042627 9.32 APOA1 APOH
6 extracellular region GO:0005576 9.32 APOA1 APOH CD27 CXCL8 IL10 IL17A

Biological processes related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CD27 CXCL8 IL10 IL17A IL6 TNF
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.74 IL10 IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL8 IL10 IL6 TNF
4 cellular response to interleukin-1 GO:0071347 9.65 CXCL8 IL17A IL6
5 response to glucocorticoid GO:0051384 9.63 IL10 IL6 TNF
6 positive regulation of osteoclast differentiation GO:0045672 9.6 IL17A TNF
7 embryonic digestive tract development GO:0048566 9.59 CXCL8 TNF
8 positive regulation of chemokine production GO:0032722 9.58 IL6 TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
10 cellular response to hepatocyte growth factor stimulus GO:0035729 9.56 IL10 IL6
11 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 IL10
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL10 TNF
13 positive regulation of lipoprotein lipase activity GO:0051006 9.52 APOA1 APOH
14 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
15 immune response GO:0006955 9.5 CD27 CXCL8 IL10 IL17A IL6 MBP
16 endothelial cell apoptotic process GO:0072577 9.49 IL10 TNF
17 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.43 IL6 TNF
18 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.43 APOA1 IL10 MBP
19 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.33 APOA1 IL10 TNF
21 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.92 IL10 MMP2 MMP9 TNF

Molecular functions related to Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AMPH APOA1 APOH AQP4 CD27 CXCL8
2 phospholipid binding GO:0005543 9.33 AMPH APOA1 APOH
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL17A IL6 TNF

Sources for Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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