MCID: TRN034
MIFTS: 53

Transverse Myelitis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Transverse Myelitis

MalaCards integrated aliases for Transverse Myelitis:

Name: Transverse Myelitis 49 50
Myelitis, Transverse 69
Myelitis Transverse 51

Classifications:



External Ids:

UMLS 69 C0026976

Summaries for Transverse Myelitis

NINDS : 50 Transverse myelitis is an inflammation of the spinal cord. The inflammation interrupts communications between nerve fibers in the spinal cord and the rest of the body, affectng sensation and nerve signaling below the damage to the protective nerve coating called myelin. The segment of the spinal cord at which the damage occurs determines which parts of the body are affected. Damage at one segment will affect function at that level and below. In people with transverse myelitis, the myelin damage most often occurs in neres in the upper back, causing problems with leg movement and bowel and bladder control, which require signals from the lower segments of the spinal cord.  Classic symptoms include weakness of the arms and legs; sensory alterations such as burning, pricking, numbness, or sensory loss;  pain (usually in the lower back or down the legs and arms or around the torso); and bowel and bladder dysfunction. Symptoms may develop suddenly or over days or weeks. Some cases of transverse myelitis occur on their own, but a number of conditions appear to cause the disorder, including immune system disorders, bacteial and viral infections, fungal infections, and various parasites.  Transverse myelitis can affect people of any age, but a peak in incidence rates appears to occur between 10 and 19 years of age and 30 to 39 years of age.

MalaCards based summary : Transverse Myelitis, also known as myelitis, transverse, is related to neuromyelitis optica and acute transverse myelitis. An important gene associated with Transverse Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Interferon beta-1a and interferons have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, b cells and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

NIH Rare Diseases : 49 Transverse myelitis is a neurological disorder caused by inflammation across both sides of one level, or segment, of the spinal cord. The term myelitis refers to inflammation of the spinal cord; transverse describes the position of the inflammation, that is, across the width of the spinal cord. Attacks of inflammation can damage or destroy myelin, the fatty insulating substance that covers nerve cell fibers. This damage causes nervous system scars that interrupt communications between the nerves in the spinal cord and the rest of the body. Transverse myelitis is part of a spectrum of neuroimmunologic diseases of the central nervous system. Other disorders in this spectrum include, Acute Disseminated Encephalomyelitis (ADEM), Optic Neuritis, and Neuromyelitis Optica (Devic's disease). Last updated: 9/2/2015

Wikipedia : 72 Transverse myelitis is a rare neurological condition in which the spinal cord is inflamed. The... more...

Related Diseases for Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 neuromyelitis optica 32.5 AQP4 IL17A IL6 MBP
2 acute transverse myelitis 32.4 APOA1 AQP4 CXCL8 IL10 IL6 MMP2
3 systemic lupus erythematosus 31.6 APOH IL10 IL17A IL6 TNF
4 myelitis 31.3 APOH AQP4 IL17A IL6 MBP MMP2
5 arteriovenous fistula 30.5 APOH IL6
6 acute disseminated encephalomyelitis 30.3 AQP4 IL10 MBP
7 optic neuritis 30.3 AQP4 MBP TNF
8 lyme disease 30.3 IL17A IL6 TNF
9 neurosyphilis 30.3 IL10 IL17A
10 neuritis 30.3 AQP4 MBP TNF
11 pneumonia 30.2 CXCL8 IL10 IL6 TNF
12 back pain 30.1 IL6 MMP9
13 ischemic colitis 30.1 APOH MMP9
14 spondylitis 29.9 IL17A IL6 TNF
15 mixed connective tissue disease 29.9 IL10 IL6 TNF
16 mycobacterium tuberculosis 1 29.9 IL10 IL17A TNF
17 myasthenia gravis 29.8 IL10 MBP TNF
18 intracranial hypertension 29.8 APOH AQP4 TNF
19 melioidosis 29.7 IL10 IL6 TNF
20 myocarditis 29.7 IL17A IL6 TNF
21 connective tissue disease 29.6 APOH IL10 IL6 TNF
22 pertussis 29.6 IL10 IL6 TNF
23 aseptic meningitis 29.6 CXCL8 IL10 TNF
24 meningitis 29.6 CXCL8 IL10 IL6 MMP9 TNF
25 colitis 29.3 CXCL8 IL10 IL17A IL6 TNF
26 cytomegalovirus infection 29.3 CXCL8 IL10 IL6 TNF
27 leptospirosis 29.3 CXCL8 IL10 IL6 TNF
28 brucellosis 29.3 CXCL8 IL10 IL6 TNF
29 osteomyelitis 29.3 CXCL8 IL10 IL6 TNF
30 chlamydia 29.3 CXCL8 IL10 IL6 TNF
31 ulcerative colitis 29.3 CXCL8 IL10 IL6 TNF
32 common variable immunodeficiency 29.2 CD27 IL10 IL6 TNF
33 rheumatoid arthritis 29.1 CXCL8 IL10 IL17A IL6 TNF
34 multiple sclerosis 29.0 AQP4 IL10 IL17A IL6 MBP MMP9
35 spinal cord injury 29.0 AQP4 CXCL8 IL6 MMP9 TNF
36 psoriasis 28.9 CXCL8 IL10 IL17A IL6 TNF
37 arthritis 28.9 CXCL8 IL10 IL17A IL6 MMP9 TNF
38 demyelinating disease 28.9 AQP4 IL10 IL17A MBP MMP9 TNF
39 idiopathic acute transverse myelitis 12.4
40 secondary acute transverse myelitis 12.3
41 antiphospholipid syndrome 11.5
42 thyrotoxic periodic paralysis 11.1
43 lupus - neurological sequelae 11.1
44 paresthesia 11.1
45 lupus erythematosus 10.5
46 eye lymphoma 10.5 IL10 IL6
47 extracranial arteriovenous malformation 10.4 MMP2 MMP9
48 diabetic foot ulcers 10.4 IL6 MMP9
49 recurrent corneal erosion 10.4 CXCL8 IL6
50 focal myositis 10.4 MMP2 MMP9

Graphical network of the top 20 diseases related to Transverse Myelitis:



Diseases related to Transverse Myelitis

Symptoms & Phenotypes for Transverse Myelitis

GenomeRNAi Phenotypes related to Transverse Myelitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 APOH CXCL8 IL10 IL17A TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 APOH CD27 CXCL8 IL10 IL17A TNF

MGI Mouse Phenotypes related to Transverse Myelitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 TNF MMP2 IL10 MMP9 IL17A IL6
2 homeostasis/metabolism MP:0005376 10.02 TNF MMP2 IL10 MMP9 IL17A APOA1
3 endocrine/exocrine gland MP:0005379 9.95 TNF IL10 AMPH IL17A APOA1 IL6
4 digestive/alimentary MP:0005381 9.91 TNF MMP9 IL10 IL17A IL6 AQP4
5 immune system MP:0005387 9.91 TNF MMP2 IL10 MMP9 IL17A IL6
6 mortality/aging MP:0010768 9.85 TNF MMP2 IL10 MMP9 IL17A AMPH
7 respiratory system MP:0005388 9.5 TNF MMP2 IL10 MMP9 IL17A IL6
8 vision/eye MP:0005391 9.17 TNF MMP2 IL10 MMP9 IL6 AQP4

Drugs & Therapeutics for Transverse Myelitis

Drugs for Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
2 interferons Phase 4
3 Adjuvants, Immunologic Phase 4
4 Anti-Infective Agents Phase 4
5 Interferon-beta Phase 4
6 Antiviral Agents Phase 4
7
Prednisolone Approved, Vet_approved Phase 3,Phase 1 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1 83-43-2 6741
9 Prednisolone acetate Phase 3,Phase 1
10 glucocorticoids Phase 3,Phase 1
11 Methylprednisolone acetate Phase 3,Phase 1
12 Methylprednisolone Hemisuccinate Phase 3,Phase 1
13 Gastrointestinal Agents Phase 3,Phase 1
14 Neuroprotective Agents Phase 3,Phase 1
15 Hormone Antagonists Phase 3,Phase 1
16 Hormones Phase 3,Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
18 Peripheral Nervous System Agents Phase 3,Phase 1
19 Antiemetics Phase 3,Phase 1
20 Prednisolone hemisuccinate Phase 3,Phase 1
21 Prednisolone phosphate Phase 3,Phase 1
22 Anti-Inflammatory Agents Phase 3,Phase 1
23 Protective Agents Phase 3,Phase 1
24 Antineoplastic Agents, Hormonal Phase 3,Phase 1
25 Autonomic Agents Phase 3,Phase 1
26 Immunoglobulins Phase 3,Phase 1
27 Antibodies Phase 3,Phase 1
28 Rho(D) Immune Globulin Phase 3
29 gamma-Globulins Phase 3
30 Immunoglobulins, Intravenous Phase 3
31
4-Aminopyridine Approved Phase 2 504-24-5 1727
32 Potassium Channel Blockers Phase 2
33 Immunosuppressive Agents Phase 1, Phase 2
34
Protein C Approved Phase 1
35
rituximab Approved Phase 1 174722-31-7 10201696
36
Bevacizumab Approved, Investigational Phase 1 216974-75-3
37
protease inhibitors Phase 1
38 Serine Proteinase Inhibitors Phase 1
39 Alpha 1-Antitrypsin Phase 1
40 Trypsin Inhibitors Phase 1
41 HIV Protease Inhibitors Phase 1
42 Protein C Inhibitor Phase 1
43 Complement C1 Inactivator Proteins Phase 1
44 Complement C1 Inhibitor Protein Phase 1
45 Complement C1s Phase 1
46 Complement Inactivating Agents Phase 1
47 Complement System Proteins Phase 1
48 Angiogenesis Inhibitors Phase 1
49 Angiogenesis Modulating Agents Phase 1
50 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show all 25)

# Name Status NCT ID Phase Drugs
1 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study) Active, not recruiting NCT01892345 Phase 3 Eculizumab
4 An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients Enrolling by invitation NCT02003144 Phase 3
5 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
6 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
7 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica Unknown status NCT01364246 Phase 1, Phase 2
8 Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
9 A Longitudinal Study of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active NMOSD Active, not recruiting NCT03062579 Phase 1, Phase 2 Tocilizumab
10 Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica Relapses Unknown status NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
11 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab
12 Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations Completed NCT01777412 Phase 1 Bevacizumab
13 C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
14 Central Pain Study for ABX-1431 Recruiting NCT03138421 Phase 1 ABX-1431 HCl;Placebo
15 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1 Ublituximab
16 Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct Unknown status NCT01024985
17 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
18 Clinical Trial of a Serious Game for Individuals With SCI/D Completed NCT02341950
19 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Recruiting NCT03336762
20 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
21 The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
22 The French Cohort and Biobank of Devic's Neuromyelitis Optica and Related Neurological Disorders (NMOSD) (NOMADMUS) Recruiting NCT02850705
23 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
24 Maintenance Plasma Exchange for Neuromyelitis Optica Active, not recruiting NCT01500681
25 Serum Auto-Antibodies in Neurological Diseases Enrolling by invitation NCT00704626

Search NIH Clinical Center for Transverse Myelitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Transverse Myelitis

Anatomical Context for Transverse Myelitis

MalaCards organs/tissues related to Transverse Myelitis:

38
Spinal Cord, B Cells, Brain, Thyroid, Bone Marrow, Kidney, Lung

Publications for Transverse Myelitis

Articles related to Transverse Myelitis:

(show top 50) (show all 647)
# Title Authors Year
1
Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient: Case Report and Review of the Current Literature. ( 29372173 )
2018
2
Evaluation of idiopathic transverse myelitis revealing specific myelopathy diagnoses. ( 29247071 )
2018
3
Reversible paraspinal muscle hyperintensity in anti-MOG antibody-associated transverse myelitis. ( 29114566 )
2018
4
Cytomegalovirus associated longitudinally extensive transverse myelitis and acute hepatitis in an immunocompetent adult. ( 29396069 )
2018
5
MOG-antibody demyelinating diseases: a case of post-partum severe rhombencephalitis and transverse myelitis. ( 29438836 )
2018
6
Guillain-BarrAc syndrome, transverse myelitis and infectious diseases. ( 29375121 )
2018
7
MRI Features of Aquaporin-4 Antibody-Positive Longitudinally Extensive Transverse Myelitis: Insights into the Diagnosis of Neuromyelitis Optica Spectrum Disorders. ( 29449281 )
2018
8
Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. ( 29294596 )
2018
9
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
10
CLIPPERS with longitudinally extensive transverse myelitis: Role of T versus B cells. ( 29406923 )
2018
11
Occult Disseminated Tuberculosis with Holocord Longitudinally Extensive Transverse Myelitis: A Rare Phenomenon in a Child. ( 29204202 )
2017
12
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
13
A Rare Infectious Cause of Transverse Myelitis. ( 28004628 )
2017
14
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
15
Chiari I malformation in children with transverse myelitis. ( 28537458 )
2017
16
Concomitant Transverse Myelitis and Acute Axonal Sensory-Motor Neuropathy in an Elderly Patient. ( 28785494 )
2017
17
Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder with recurrent short partial transverse myelitis and favorable prognosis: Two new cases. ( 28580873 )
2017
18
Subacute Progressive Myelopathy: Transverse Myelitis or Subacute Combined Degeneration? A Case Report. ( 28797832 )
2017
19
Clinical outcomes and predictive factors related to good outcomes in plasma exchange in severe attack of NMOSD and long extensive transverse myelitis: Case series and review of the literature. ( 28427710 )
2017
20
Longitudinally extensive transverse myelitis after<i>Campylobacter jejuni</i>enteritis. ( 29273615 )
2017
21
Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis. ( 29249004 )
2017
22
Transverse myelitis following methotrexate treatment of ectopic pregnancy: a case report. ( 29260596 )
2017
23
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
24
Clinical commentary on 'Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder with recurrent short partial transverse myelitis and favorable prognosis: Two new cases', by Wang et al. ( 28580877 )
2017
25
Ventriculoperitoneal Shunt-Associated Vancomycin-Resistant Meningitis Complicating a Patient Undergoing Plasmapheresis for Presumed Systemic Lupus Erythematosus-Associated Transverse Myelitis. ( 29109928 )
2017
26
Acute motor axonal neuropathy and transverse myelitis overlap: the importance of history taking. ( 29143293 )
2017
27
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
28
Transverse myelitis as an unexpected complication following treatment with dinutuximab in pediatric patients with high-risk neuroblastoma: A case series. ( 28748630 )
2017
29
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
30
Longitudinally Extensive Transverse Myelitis and Optic Neuropathy Associated with Syphilitic Meningomyelitis and Human Immunodeficiency Virus Infection: A Case Report and Review of the Literature. ( 28768983 )
2017
31
Pediatric acute transverse myelitis. ( 28678221 )
2017
32
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
33
Comorbidity of narcolepsy with cataplexy and transverse myelitis: aA common autoimmune background? A case report. ( 28449899 )
2017
34
Case series of two patients with Fibrocartilaginous Embolism mimicking Transverse Myelitis of the Spinal Cord. ( 28246010 )
2017
35
A multicentre randomiSed controlled TRial of IntraVEnous immunoglobulin compared with standard therapy for the treatment of transverse myelitis in adults and children (STRIVE). ( 28639937 )
2017
36
Effect of Electroacupuncture Rehabilitation in Transverse Myelitis: A Case Report. ( 28889845 )
2017
37
Cytomegalovirus-related transverse myelitis in an immunocompetent host: a subacute onset of an immune-mediated disease? ( 28801328 )
2017
38
Refractory Longitudinally Extensive Transverse Myelitis Responsive to Cyclophosphamide. ( 28724464 )
2017
39
Acute paraparesis and sensory loss following intravenous corticosteroid administration in a case of longitudinally extensive transverse myelitis caused by spinal dural arteriovenous fistula: case report and review of literature. ( 28546874 )
2017
40
Longitudinal extensive transverse myelitis with an abnormal uFLC ratio in a pediatric patient: Case report and literature review. ( 29384915 )
2017
41
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
42
Randomized, Placebo-controlled Crossover Study of Dalfampridine Extended-release in Transverse Myelitis. ( 29270309 )
2017
43
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
44
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
45
Optical Coherence Tomography and Subclinical Optical Neuritis in Longitudinally Extensive Transverse Myelitis. ( 29184337 )
2017
46
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
47
Poster 348 Biospy-Confirmed Neurosarcoidosis Manifesting as a Non-Compressive Myelopathy with Transverse Myelitis and Normal ACE Level: A Case Study. ( 27673101 )
2016
48
Relapsing optic neuritis and isolated transverse myelitis are the predominant clinical phenotypes for patients with antibodies to myelin oligodendrocyte glycoprotein in India. ( 28607742 )
2016
49
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
50
Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status. ( 27538606 )
2016

Variations for Transverse Myelitis

Expression for Transverse Myelitis

Search GEO for disease gene expression data for Transverse Myelitis.

Pathways for Transverse Myelitis

Pathways related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 CD27 CXCL8 IL10 IL17A IL6 TNF
2
Show member pathways
13.27 CD27 CXCL8 IL10 IL17A IL6 MMP2
3
Show member pathways
13.22 CD27 CXCL8 IL10 IL17A IL6 TNF
4
Show member pathways
12.79 CXCL8 IL10 IL17A IL6 TNF
5
Show member pathways
12.55 IL10 IL17A IL6 MMP2 TNF
6
Show member pathways
12.53 IL10 IL17A IL6 TNF
7
Show member pathways
12.51 CXCL8 IL6 MMP9 TNF
8
Show member pathways
12.48 CXCL8 IL10 IL6 TNF
9
Show member pathways
12.38 IL10 IL17A IL6 TNF
10
Show member pathways
12.28 CXCL8 IL17A IL6 MMP9 TNF
11 12.15 IL6 MMP2 MMP9 TNF
12 12.1 AQP4 CXCL8 IL10 IL6 TNF
13 12.02 MMP2 MMP9 TNF
14
Show member pathways
12.01 CXCL8 IL10 IL17A IL6 TNF
15 11.94 IL10 IL6 TNF
16
Show member pathways
11.92 IL10 IL17A IL6 TNF
17 11.9 IL6 MMP9 TNF
18 11.89 CXCL8 IL6 MMP2 TNF
19 11.87 CXCL8 IL10 IL6 TNF
20
Show member pathways
11.86 MMP2 MMP9 TNF
21
Show member pathways
11.82 CXCL8 IL17A IL6
22 11.82 CXCL8 IL17A IL6 TNF
23 11.75 IL10 IL17A TNF
24 11.75 CXCL8 MMP2 MMP9
25 11.72 CXCL8 IL10 IL6 TNF
26 11.71 IL10 IL6 TNF
27 11.7 CXCL8 MMP2 MMP9
28 11.65 IL10 IL6 TNF
29 11.64 CXCL8 IL6 MMP2 MMP9
30 11.61 CXCL8 MMP2 MMP9
31 11.56 CXCL8 IL6 MMP2
32 11.55 CXCL8 IL6 TNF
33 11.52 IL6 MMP2 TNF
34 11.51 AQP4 CXCL8 IL6 MBP MMP9 TNF
35 11.47 CXCL8 IL10 IL6 TNF
36 11.45 CXCL8 IL10 IL6 TNF
37 11.45 CXCL8 IL6 MMP2 MMP9 TNF
38 11.42 IL6 MMP2 MMP9 TNF
39
Show member pathways
11.35 CXCL8 IL6 MMP2 MMP9 TNF
40 11.34 IL10 IL6 TNF
41 11.29 IL17A IL6 TNF
42 11.26 IL10 IL6 TNF
43 11.22 CXCL8 IL10 IL17A IL6 MMP2 MMP9
44 11.21 APOA1 IL10 IL6 TNF
45 11.15 CXCL8 IL6 MMP2 MMP9
46 11.14 CXCL8 IL10 IL17A IL6 TNF
47 11.03 CXCL8 IL6 TNF
48 10.96 CXCL8 IL10 IL17A IL6 TNF

GO Terms for Transverse Myelitis

Cellular components related to Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.62 APOA1 APOH MMP2 MMP9
2 extracellular space GO:0005615 9.61 APOA1 APOH CXCL8 IL10 IL17A IL6
3 external side of plasma membrane GO:0009897 9.46 AQP4 CD27 IL17A TNF
4 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOH
5 extracellular region GO:0005576 9.32 APOA1 APOH CD27 CXCL8 IL10 IL17A
6 chylomicron GO:0042627 9.26 APOA1 APOH

Biological processes related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.83 CXCL8 IL10 IL17A IL6 TNF
2 inflammatory response GO:0006954 9.8 CD27 CXCL8 IL10 IL17A IL6 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.72 IL10 IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL8 IL10 IL6 TNF
5 response to glucocorticoid GO:0051384 9.63 IL10 IL6 TNF
6 positive regulation of osteoclast differentiation GO:0045672 9.58 IL17A TNF
7 positive regulation of chemokine production GO:0032722 9.58 IL6 TNF
8 embryonic digestive tract development GO:0048566 9.57 CXCL8 TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.56 IL10 TNF
10 response to molecule of bacterial origin GO:0002237 9.54 CXCL8 IL10
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL10 TNF
12 positive regulation of lipoprotein lipase activity GO:0051006 9.51 APOA1 APOH
13 immune response GO:0006955 9.5 CD27 CXCL8 IL10 IL17A IL6 MBP
14 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
15 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
16 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.43 APOA1 IL10 MBP
17 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
18 negative regulation of cytokine secretion involved in immune response GO:0002740 9.33 APOA1 IL10 TNF
19 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.92 IL10 MMP2 MMP9 TNF

Molecular functions related to Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AMPH APOA1 APOH AQP4 CD27 CXCL8
2 phospholipid binding GO:0005543 9.33 AMPH APOA1 APOH
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL17A IL6 TNF

Sources for Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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