MCID: TRM010
MIFTS: 53

Traumatic Brain Injury malady

Neuronal diseases category

Summaries for Traumatic Brain Injury

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Sources:
35MedlinePlus, 4CDC, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Traumatic brain injury (tbi) happens when a bump, blow, jolt, or other head injury causes damage to the brain. every year, millions of people in the u.s. suffer brain injuries. more than half are bad enough that people must go to the hospital. the worst injuries can lead to permanent brain damage or death. half of all tbis are from motor vehicle accidents. military personnel in combat zones are also at risk. symptoms of a tbi may not appear until days or weeks following the injury. a concussion is the mildest type. it can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. people with a moderate or severe tbi may have those, plus other symptoms: a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures inability to awaken from sleep slurred speech weakness or numbness in the arms and legs dilated eye pupils health care professionals use a neurological exam and imaging tests to assess tbi. serious traumatic brain injuries need emergency treatment. treatment and outcome depend on how severe the injury is. tbi can cause a wide range of changes affecting thinking, sensation, language, or emotions. tbi can be associated with post-traumatic stress disorder. people with severe injuries usually need rehabilitation. nih: national institutes of neurological disorders and stroke

MalaCards: Traumatic Brain Injury is related to brain edema and schizophrenia. An important gene associated with Traumatic Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and A-beta Uptake and Degradation. The compounds l-trans-pyrrolidine-2,4-dicarboxylic acid and dl-threo-beta-benzyloxyaspartate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are vision/eye and behavior/neurological.

CDC:4 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. In 2010 2.5 million TBIs occured either as an isolated injury or along with other injuries.1

NINDS:45 Traumatic brain injury (TBI), a form of

Wikipedia:66 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force... more...

Aliases & Classifications for Traumatic Brain Injury

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Sources:
45NINDS, 35MedlinePlus, 32LifeMap Discoveryā„¢
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

traumatic brain injury 45 35 32


Related Diseases for Traumatic Brain Injury

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to traumatic brain injury

Symptoms for Traumatic Brain Injury

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Drugs & Therapeutics for Traumatic Brain Injury

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Traumatic Brain Injury

Drug clinical trials:

Search ClinicalTrials for Traumatic Brain Injury

Search NIH Clinical Center for Traumatic Brain Injury

Search CenterWatch for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119

Genetic Tests for Traumatic Brain Injury

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Anatomical Context for Traumatic Brain Injury

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Traumatic Brain Injury:

34
Brain, Testes, Eye, Bone, Pituitary, Cortex, Bone marrow, Heart, Prefrontal cortex, Endothelial, Spinal cord, Smooth muscle, Monocytes, Hypothalamus, T cells, Myeloid, Thyroid, Liver, Lung, Kidney, Medulla oblongata

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Traumatic Brain Injury or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Traumatic Brain Injury:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9SLC1A3, SLC1A1, MIP, APOE, GFAP
2MP:00053867.5SLC1A2, GFAP, APOE, ACE, S100B, SLC1A1
3MP:00053767.1CYSLTR2, GFAP, APOE, ACE, SLC1A1, SLC1A7

Publications for Traumatic Brain Injury

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Sources:
53PubMed
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Articles related to Traumatic Brain Injury:

(show top 50)    (show all 1049)
idTitleAuthorsYear
1
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is neuroprotective in experimental traumatic brain injury. (24392832)
2014
2
Discharge Planning Difficulties for Patients With Traumatic Brain Injury: Unique Funding Options. (24413072)
2014
3
Blood-brain barrier and traumatic brain injury. (24327344)
2014
4
Saccadic eye movements in mild traumatic brain injury: a pilot study. (24384339)
2014
5
Understanding practice: the factors that influence management of mild traumatic brain injury in the emergency department-a qualitative study using the Theoretical Domains Framework. (24418161)
2014
6
High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4. (24166800)
2014
7
Preliminary examination of the impact of traumatic brain injury and posttraumatic stress disorder on self-regulated learning and academic achievement among military service members enrolled in postsecondary education. (23982790)
2014
8
Risk and Mortality of Traumatic Brain Injury in Stroke Patients: Two Nationwide Cohort Studies. (24263175)
2013
9
Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-I+. (24312187)
2013
10
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
11
Emerging pharmacological agents to improve survival from traumatic brain injury. (24205899)
2013
12
Anaesthesiologist-provided prehospital airway management in patients with traumatic brain injury: an observational study. (24368407)
2013
13
Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. (24102309)
2013
14
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
15
Optimization of the pattern visual evoked potential (VEP) in the visually-normal and mild traumatic brain injury (mTBI) populations. (24111626)
2013
16
Quality of life after traumatic brain injury: Finnish experience of the QOLIBRI in residential rehabilitation. (24002322)
2013
17
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
18
The negative impact of traumatic brain injury (TBI) on bone in a mouse model. (24295038)
2013
19
Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury. (24002317)
2013
20
Hypernatremia in patients with severe traumatic brain injury: a systematic review. (24196399)
2013
21
Micronutrients in brain function, and traumatic brain injury. (24047958)
2013
22
Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? (23546937)
2013
23
Comparison of error-based and errorless learning for people with severe traumatic brain injury: study protocol for a randomized control trial. (24192067)
2013
24
Life satisfaction 6-15 years after a traumatic brain injury. (23995834)
2013
25
A systematic review of psychosocial outcomes within 2 years of paediatric traumatic brain injury in a school-aged population. (24020439)
2013
26
Neurocognitive function differentiation from the effect of psychopathologic symptoms in the disability evaluation of patients with mild traumatic brain injury. (24379945)
2013
27
Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury. (23198799)
2013
28
Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and P38 MAPK signalling pathway. (24131109)
2013
29
Health-related quality of life 12 months after severe traumatic brain injury: a prospective nationwide cohort study. (24002315)
2013
30
Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: A meta-analysis. (24360821)
2013
31
Motor rehabilitation in stroke and traumatic brain injury: stimulating and intense. (24141528)
2013
32
Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease. (22543850)
2012
33
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
34
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
35
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
36
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
37
The association between apolipoprotein E and traumatic brain injury severity and functional outcome in a rehabilitation sample. (21651315)
2011
38
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
39
Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. (20050894)
2010
40
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
41
Severe traumatic brain injury complicated by status asthmaticus: favorable neurological outcome despite excessive hypercapnia. (16612314)
2006
42
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
43
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
44
Lesional expression of RhoA and RhoB following traumatic brain injury in humans. (15253798)
2004
45
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. (12854754)
2003
46
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. (11777556)
2002
47
S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. (11393252)
2001
48
Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. (10701532)
2000
49
Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (9585713)
1998
50
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. (9257663)
1997

Variations for Traumatic Brain Injury

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Expression for genes affiliated with Traumatic Brain Injury

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for genes affiliated with Traumatic Brain Injury

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 55R&D Systems, 31KEGG, 54QIAGEN, 13EMD Millipore, 5Cell Signaling Technology
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Pathways related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0SLC1A3, SLC1A2
29.9ACE, APOE
3
Show member pathways
9.7S100B, GFAP
4
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.7SLC1A2, SLC1A3, SLC1A1
5
Show member pathways
9.7SLC1A2, SLC1A3, SLC1A1
6
Show member pathways
8.8SLC1A6, SLC1A7, SLC1A1
78.7SLC1A2, SLC1A3, SLC1A1, S100B, APOE, GFAP
8
Show member pathways
8.3SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
9
Show member pathways
8.3SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
10
Show member pathways
7.9MIP, SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Compounds for genes affiliated with Traumatic Brain Injury

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1l-trans-pyrrolidine-2,4-dicarboxylic acid4610.3SLC1A2, SLC1A3
2dl-threo-beta-benzyloxyaspartate4610.3SLC1A3, SLC1A2
3threo-beta-hydroxyaspartate4610.3SLC1A3, SLC1A1
4[3h](2s,4r)-4-methylglutamate3010.3SLC1A2, SLC1A3
5edss4610.2APOE, S100B
6dihydrokainate46 3011.1SLC1A3, SLC1A2, SLC1A1
7eosin4610.0GFAP, S100B
8s 1004610.0GFAP, S100B
9sele4610.0APOE, ACE
10threo-3-methylglutamate309.9SLC1A2, SLC1A6
112,3-cyclic nucleotide469.9GFAP, S100B
12reticulin469.7GFAP, S100B
13dbc-amp469.6GFAP, SLC1A3, SLC1A2, S100B
14inositol469.5SLC1A2, SLC1A3, GFAP
15acetylcholine46 52 30 25 1213.5APOE, GFAP, ACE, S100B
16kainate46 3010.4APOE, SLC1A2, SLC1A3, SLC1A1, GFAP
17bromodeoxyuridine469.4GFAP, S100B, AIF1
18dopamine46 30 25 1212.4GFAP, APOE, SLC1A2, S100B
19gaba469.4SLC1A3, SLC1A1, S100B, GFAP, SLC1A2
20lactate469.3S100B, MIP, GFAP, SLC1A2
21hydrogen46 2510.2MIP, SLC1A1, CYSLTR2, S100B
22potassium46 25 1211.2GFAP, ACE, S100B, MIP, SLC1A1
23glutamine469.1S100B, SLC1A3, APOE, GFAP, SLC1A2, SLC1A1
24alanine469.1S100B, SLC1A1, SLC1A3, SLC1A2, APOE, GFAP
25adenylate469.1SLC1A3, S100B, GFAP, SLC1A2, CYSLTR2
26serine469.0SLC1A1, S100B, APOE, GFAP, SLC1A2, SLC1A3
27creatinine468.9APOE, ACE, S100B, GFAP
28vegf468.9APOE, S100B, GFAP, MIP, CYSLTR2
29nitric oxide46 25 1210.8CYSLTR2, SLC1A2, SLC1A3, S100B, ACE, MIP
30oxygen46 259.8CYSLTR2, GFAP, MIP, S100B, SLC1A2
31atp46 309.8CYSLTR2, GFAP, MIP, SLC1A3, S100B
32dihydrokainic acid628.7SLC1A1, SLC1A3, SLC1A6, SLC1A2, SLC1A7
33cysteine468.7GFAP, APOE, MIP, S100B, SLC1A2, SLC1A3
34tfb-tboa628.7SLC1A3, SLC1A2, SLC1A6, SLC1A7, SLC1A1
35l-trans-2,4-pdc628.7SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
36[3h]etb-tboa308.7SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
37[3h]l-aspartic acid308.7SLC1A6, SLC1A2, SLC1A1, SLC1A7, SLC1A3
38way 213613628.7SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
39dl-tboa62 309.7SLC1A1, SLC1A7, SLC1A2, SLC1A3, SLC1A6
40[3h]d-aspartic acid308.7SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
41glucose468.7ACE, GFAP, SLC1A2, SLC1A3, SLC1A1, S100B
42l-glutamic acid30 25 1210.7SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
43arginine468.7CYSLTR2, GFAP, APOE, MIP, S100B, SLC1A2
44nmda46 309.6SLC1A1, GFAP, SLC1A2, SLC1A3, SLC1A7, APOE
45aspartate468.5SLC1A6, GFAP, APOE, S100B, SLC1A3, SLC1A1
46lipid468.4ACE, MIP, SLC1A2, APOE, GFAP, CYSLTR2
47chloride468.3SLC1A6, SLC1A3, SLC1A7, SLC1A2, MIP, SLC1A1
48sodium46 259.0MIP, ACE, SLC1A3, SLC1A6, SLC1A2, SLC1A1
49calcium46 52 25 1210.6SLC1A2, SLC1A1, AIF1, ACE, S100B, CAPNS2
50glutamate467.3MIP, GFAP, APOE, S100B, SLC1A1, SLC1A7

GO Terms for genes affiliated with Traumatic Brain Injury

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Sources:
17Gene Ontology
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Cellular components related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.6SLC1A3, S100B, APOE
2membraneGO:0160208.4GFAP, SLC1A1, SLC1A3, SLC1A6, SLC1A2
3plasma membraneGO:0058866.2SLC1A2, CYSLTR2, APOE, MIP, ACE, CAPNS2

Biological processes related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1D-aspartate importGO:0707799.9SLC1A2, SLC1A3, SLC1A1
2L-glutamate importGO:0519389.9SLC1A2, SLC1A3, SLC1A1
3long-term synaptic potentiationGO:0602919.7S100B, GFAP
4response to woundingGO:0096119.6GFAP, SLC1A3, SLC1A2
5regulation of neuronal synaptic plasticityGO:0481689.6S100B, APOE
6L-glutamate transportGO:0158139.0SLC1A6, SLC1A7
7synaptic transmissionGO:0072689.0SLC1A1, SLC1A3, SLC1A6, SLC1A2
8ion transportGO:0068118.4SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
9transmembrane transportGO:0550858.0MIP, SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Molecular functions related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.0SLC1A3, SLC1A1
2glutamate:sodium symporter activityGO:0155019.9SLC1A2, SLC1A1
3tau protein bindingGO:0481569.6S100B, APOE
4sodium:dicarboxylate symporter activityGO:0171538.3SLC1A7, SLC1A3, SLC1A6, SLC1A2, SLC1A1
5L-glutamate transmembrane transporter activityGO:0053138.3SLC1A2, SLC1A1, SLC1A7, SLC1A3, SLC1A6

Products for genes affiliated with Traumatic Brain Injury

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Traumatic Brain Injury

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet