MCID: TRM010
MIFTS: 54

Traumatic Brain Injury

Categories: Neuronal diseases

Aliases & Classifications for Traumatic Brain Injury

MalaCards integrated aliases for Traumatic Brain Injury:

Name: Traumatic Brain Injury 37 50 40 3

Classifications:



Summaries for Traumatic Brain Injury

MedlinePlus : 40 Traumatic brain injury (TBI) happens when a bump, blow, jolt, or other head injury causes damage to the brain. Every year, millions of people in the U.S. suffer brain injuries. More than half are bad enough that people must go to the hospital. The worst injuries can lead to permanent brain damage or death. Half of all TBIs are from motor vehicle accidents. Military personnel in combat zones are also at risk. Symptoms of a TBI may not appear until days or weeks following the injury. A concussion is the mildest type. It can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. People with a moderate or severe TBI may have those, plus other symptoms: A headache that gets worse or does not go away Repeated vomiting or nausea Convulsions or seizures Inability to awaken from sleep Slurred speech Weakness or numbness in the arms and legs Dilated eye pupils Health care professionals use a neurological exam and imaging tests to assess TBI. Serious traumatic brain injuries need emergency treatment. Treatment and outcome depend on how severe the injury is. TBI can cause a wide range of changes affecting thinking, sensation, language, or emotions. TBI can be associated with post-traumatic stress disorder. People with severe injuries usually need rehabilitation. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Traumatic Brain Injury is related to head injury and persistent vegetative state. An important gene associated with Traumatic Brain Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways are Neuroscience and Interleukin-4 and 13 signaling. The drugs Midazolam and Propofol have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and testes, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

CDC : 3 CDC defines a traumatic brain injury (TBI) as a disruption in the normal function of the brain that can be caused by a bump, blow, or jolt to the head, or penetrating head injury. Everyone is at risk for a TBI, especially children and older adults.

NINDS : 50 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

Wikipedia : 72 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures... more...

Related Diseases for Traumatic Brain Injury

Diseases related to Traumatic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 head injury 33.0 APOE ENO2 S100B
2 persistent vegetative state 32.8 APOE ENO2
3 post-traumatic stress disorder 30.5 BDNF COMT DRD2
4 psychotic disorder 30.1 BDNF COMT DRD2 S100B
5 chiari malformation 30.0 GFAP MBP
6 paranoid schizophrenia 30.0 BDNF COMT S100B
7 status epilepticus 30.0 BDNF CASP3 ENO2 GFAP
8 hydrocephalus 29.8 APOE ENO2 GFAP IGF1 MBP
9 alzheimer disease 29.7 APOE BDNF CASP3 GFAP S100B UCHL1
10 spinal cord injury 29.7 AQP4 BDNF CASP3 GFAP IL6
11 personality disorder 29.6 BDNF COMT DRD2
12 substance abuse 29.6 BDNF COMT DRD2
13 bacterial meningitis 29.6 IL10 IL6 S100B
14 disease of mental health 29.4 APOE BDNF COMT DRD2
15 obsessive-compulsive disorder 29.4 BDNF COMT DRD2
16 mood disorder 29.4 BDNF COMT DRD2 IL6
17 major depressive disorder 29.3 BDNF COMT DRD2 IL6
18 brain injury 28.4 APOE BDNF CASP3 COMT DRD2 ENO2
19 moderate and severe traumatic brain injury 12.4
20 locked-in syndrome 11.4
21 shaken baby syndrome 11.3
22 cerebral atrophy 11.3
23 pseudobulbar affect 11.3
24 post-traumatic epilepsy 11.3
25 apraxia 11.3
26 dysphagia 11.3
27 swallowing disorders 11.3
28 agnosia 11.3
29 diarrhea 5, with tufting enteropathy, congenital 11.0
30 prosopagnosia 11.0
31 childhood apraxia of speech 11.0
32 tremor 11.0
33 dementia pugilistica 11.0
34 cerebritis 10.6
35 hypopituitarism 10.5
36 bednar tumor 10.5 ENO2 S100B
37 hydrops, lactic acidosis, and sideroblastic anemia 10.5
38 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 GFAP
39 melanotic medulloblastoma 10.5 ENO2 GFAP
40 epithelioid malignant peripheral nerve sheath tumor 10.5 ENO2 S100B
41 middle cerebral artery infarction 10.5 ENO2 S100B
42 gemistocytic astrocytoma 10.5 GFAP S100B
43 brain edema 10.5
44 neuronitis 10.5
45 ossifying fibromyxoid tumor 10.5 ENO2 S100B
46 cerebellar medulloblastoma 10.5 ENO2 GFAP
47 chordoid meningioma 10.5 GFAP S100B
48 finger agnosia 10.5 ENO2 MBP
49 central nervous system primitive neuroectodermal neoplasm 10.5 ENO2 GFAP
50 syringocystadenoma papilliferum 10.4 GFAP S100B

Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to Traumatic Brain Injury

Symptoms & Phenotypes for Traumatic Brain Injury

GenomeRNAi Phenotypes related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Traumatic Brain Injury:

43 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.46 S100B IL6 UCHL1 MBP BDNF AQP4
2 growth/size/body region MP:0005378 10.41 IL6 SPTAN1 UCHL1 MBP BDNF AQP4
3 cardiovascular system MP:0005385 10.38 IL6 SPTAN1 UCHL1 AQP4 APOE COMT
4 cellular MP:0005384 10.38 SPTAN1 IL6 MBP APOE BDNF ENO2
5 homeostasis/metabolism MP:0005376 10.38 S100B IL6 MBP UCHL1 BDNF AQP4
6 nervous system MP:0003631 10.31 IL6 SPTAN1 UCHL1 MBP AQP4 CASP3
7 hematopoietic system MP:0005397 10.29 IL6 IL10 MBP UCHL1 APOE AQP4
8 mortality/aging MP:0010768 10.29 SPTAN1 IL6 IL10 MBP UCHL1 APOE
9 digestive/alimentary MP:0005381 10.28 IL6 UCHL1 BDNF AQP4 CASP3 APOE
10 endocrine/exocrine gland MP:0005379 10.27 IL6 IL10 APOE BDNF AQP4 DRD2
11 immune system MP:0005387 10.26 IL6 IL10 MBP APOE AQP4 CASP3
12 integument MP:0010771 10.21 S100B IL6 UCHL1 APOE BDNF CASP3
13 craniofacial MP:0005382 10.07 IL10 SPTAN1 BDNF CASP3 ENO2 HIF1A
14 muscle MP:0005369 10.06 IL6 IL10 APOE CASP3 DRD2 IGF1
15 normal MP:0002873 10.06 MBP S100B SPTAN1 IL10 BDNF DRD2
16 hearing/vestibular/ear MP:0005377 10.03 MBP APOE BDNF AQP4 CASP3 IGF1
17 respiratory system MP:0005388 10.03 IL6 UCHL1 AQP4 CASP3 APOE BDNF
18 renal/urinary system MP:0005367 10.02 IL6 UCHL1 AQP4 APOE COMT CASP3
19 limbs/digits/tail MP:0005371 9.97 IL10 UCHL1 APOE DRD2 IGF1 HIF1A
20 reproductive system MP:0005389 9.97 MBP IL6 IL10 APOE BDNF CASP3
21 skeleton MP:0005390 9.76 IL6 IL10 UCHL1 APOE CASP3 DRD2
22 taste/olfaction MP:0005394 9.35 APOE BDNF ENO2 CASP3 DRD2
23 vision/eye MP:0005391 9.28 IL6 IL10 MBP APOE BDNF AQP4

Drugs & Therapeutics for Traumatic Brain Injury

Drugs for Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 422)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 2078-54-8 4943
3
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
4
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
5
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
6
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
7
Amantadine Approved Phase 4,Phase 2,Phase 3 768-94-5 2130
8
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
9 Cisatracurium Approved, Experimental Phase 4 96946-41-7
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
11
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
12
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
13
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
14
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
15
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
16
Methylphenidate Approved, Investigational Phase 4,Phase 2 20748-11-2, 113-45-1 4158
17
Heparin Approved, Investigational Phase 4,Phase 1 9005-49-6 46507594 772
18
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
19
Sertraline Approved Phase 4,Phase 2,Phase 3 79617-96-2 68617
20
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
21
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1 99-66-1 3121
22
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3 50-23-7 657311 5754
23
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
24
Rivastigmine Approved, Investigational Phase 4,Phase 3 123441-03-2 77991
25
Methyltestosterone Approved Phase 4,Phase 2 58-18-4 6010
26
Testosterone Approved, Investigational Phase 4,Phase 2 58-22-0 6013
27
Dalteparin Approved Phase 4 9005-49-6
28
Topiramate Approved Phase 4,Early Phase 1 97240-79-4 5284627
29
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
30
Phenytoin Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 57-41-0 1775
31 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2 7491-74-9
32
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
33
Tizanidine Approved, Investigational Phase 4,Phase 1 51322-75-9 5487
34
Dextromethorphan Approved Phase 4,Phase 3 125-71-3 5362449 5360696
35
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
36
Quinidine Approved, Investigational Phase 4,Phase 2 56-54-2 441074
37
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 57-83-0 5994
38
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
39
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
40
Amitriptyline Approved Phase 4,Phase 2 50-48-6 2160
41
Memantine Approved, Investigational Phase 4 19982-08-2 4054
42
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1,Phase 2 83-43-2 6741
43
Prednisolone Approved, Vet_approved Phase 4,Phase 1,Phase 2 50-24-8 5755
44
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 51-43-4 5816
45 Racepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2 329-65-7
46
Prazosin Approved Phase 4,Phase 1,Phase 2 19216-56-9 4893
47
Donepezil Approved Phase 4,Phase 3 120014-06-4 3152
48
Sumatriptan Approved, Investigational Phase 4,Phase 2 103628-46-2 5358
49
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
50
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878

Interventional clinical trials:

(show top 50) (show all 1091)

# Name Status NCT ID Phase Drugs
1 A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function Unknown status NCT01712477 Phase 4 Intravenous sedation using propofol;Intravenous sedation with midazolam
2 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
3 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
4 Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
5 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
6 Growth Hormone and Brain Functioning After Traumatic Brain Injury Unknown status NCT01699308 Phase 4 Genotropin (somatropin)
7 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
8 Amantadine for Treatment of Symptoms of the Post-Traumatic Confusional State Unknown status NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
9 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
10 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
11 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
12 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
13 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
14 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
15 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
16 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Human Growth Hormone;Placebo
17 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
18 An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
19 Pharmacological Intervention in Depression After Traumatic Brain Injury Completed NCT00205491 Phase 4 Venlafaxine
20 The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain) Completed NCT02015949 Phase 4 Methylphenidate;Placebo
21 The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
22 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
23 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
24 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
25 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
26 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
27 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
28 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
29 BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity Completed NCT00430196 Phase 4 BOTOX®;Zanaflex®
30 Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
31 Enteral Glutamine in Neurologically-injured Patients Completed NCT00204971 Phase 4
32 Spinal Clearance Study: Expediting the Spinal Clearance Process in the Major Trauma Patient Completed NCT00163826 Phase 4
33 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4 Progesterone;Placebo
34 NIMI-NICU: Non Invasive Monitoring of the Intracranial Pressure - NeuroIntensive Care Unit Completed NCT01685476 Phase 4
35 Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Practical Trial Completed NCT00680602 Phase 4 SSRI (fluoxetine, sertraline, paroxetine, citalopram)
36 Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit Completed NCT01948505 Phase 4 Intravenous acetaminophen;Placebo for IV acetaminophen
37 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
38 Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates? Recruiting NCT03054285 Phase 4 Levetiracetam
39 Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury Recruiting NCT02321761 Phase 4 Amantadine hydrochloride
40 Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits in Children Recruiting NCT02712996 Phase 4 Lisdexamfetamine;Placebo
41 Beta Blockade in in Traumatic Brain Injury Recruiting NCT02957331 Phase 4 Propranolol
42 Timing of VTE Prophylaxis in TBI Recruiting NCT03081169 Phase 4 Enoxaparin Sodium 150 MG/ML Prefilled Syringe;Heparin
43 Prazosin and CSF Biomarkers in mTBI Recruiting NCT03221751 Phase 4 prazosin hydrochloride;placebo
44 Prazosin for Post-Concussive Headaches Recruiting NCT02965027 Phase 4 Prazosin;Placebos
45 Citicholine-Amantadine Trial in Traumatic Brain Injury Active, not recruiting NCT03430817 Phase 4 Citicholine;Amantadine
46 Methylphenidate for Attention Problems After Pediatric TBI Active, not recruiting NCT01933217 Phase 4 Methylphenidate;Placebo
47 Quality Improvement and Practice Based Research in Neurology Using the EMR Enrolling by invitation NCT02670161 Phase 4 Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
48 Simvastatin for mTBI-II Suspended NCT01952288 Phase 4 simvastatin;pravastatin
49 Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury Terminated NCT00462228 Phase 4 Memantine;Placebo
50 Treatment Of Adult Growth Hormone Deficiency After Traumatic Brain Injury Terminated NCT00555009 Phase 4 Genotropin;Placebo

Search NIH Clinical Center for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 23205020 20637752 23020860 21175285 21248119

Genetic Tests for Traumatic Brain Injury

Anatomical Context for Traumatic Brain Injury

MalaCards organs/tissues related to Traumatic Brain Injury:

38
Brain, Testes, Eye, Spinal Cord, Bone, Pituitary, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Traumatic Brain Injury

Articles related to Traumatic Brain Injury:

(show top 50) (show all 1422)
# Title Authors Year
1
Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury. ( 29451222 )
2018
2
Recovery of an injured corticofugal tract from the supplementary motor area in a patient with traumatic brain injury: A case report. ( 29443731 )
2018
3
Detecting Behavioral Deficits in Rats After Traumatic Brain Injury. ( 29443022 )
2018
4
Biomechanical simulation of traumatic brain injury in the rat. ( 29449041 )
2018
5
Clinical predictive score of intracranial hemorrhage in mild traumatic brain injury. ( 29440905 )
2018
6
Post-concussive symptoms after a mild traumatic brain injury during childhood and adolescence. ( 29446658 )
2018
7
Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice. ( 29439712 )
2018
8
Continuous Remote Ischemic Conditioning Attenuates Cognitive and Motor Deficits From Moderate Traumatic Brain Injury. ( 29443855 )
2018
9
Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury: Views and Attitudes of Medical and Nursing Practitioners in the Acute Care Setting. ( 29443400 )
2018
10
Corrigendum: Image of the month: Dysphagia due to injury of the corticobulbar tract following traumatic brain injury. ( 29436459 )
2018
11
Mild traumatic brain injury: evaluation of olfactory dysfunction and clinical-neurological characteristics. ( 29446651 )
2018
12
Does Red Cell Distribution Width Predict Outcome in Traumatic Brain Injury: Comparison to Corticosteroid Randomization After Significant Head Injury. ( 29238428 )
2018
13
Utility of Retrograde Amnesia Assessment Alone, Compared with Anterograde Amnesia Assessment in Determining Recovery After Traumatic Brain Injury: Prospective Cohort Study. ( 29191531 )
2018
14
Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). ( 29444081 )
2018
15
The Risk of Traumatic Brain Injury Occurring among Patients with Parkinson'sDisease: A 14-Year Population-Based Study. ( 29452320 )
2018
16
Management of traumatic brain injury patients. ( 29441170 )
2018
17
Over Resuscitation With Plasma is Associated With Sustained Fibrinolysis Shutdown and Death in Pediatric Traumatic Brain Injury. ( 29443859 )
2018
18
Atypical Within-Session Motor Procedural Learning after Traumatic Brain Injury but Well-Preserved Between-Session Procedural Memory Consolidation. ( 29441005 )
2018
19
Evidence- and Consensus-Based Guidelines for the Management of Communication and Swallowing Disorders Following Pediatric Traumatic Brain Injury. ( 29385009 )
2018
20
Hypopituitarism 3 and 12 months after traumatic brain injury and subarachnoid haemorrhage. ( 29283287 )
2018
21
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization. ( 29448108 )
2018
22
Impaired autophagic flux is associated with the severity of trauma and the role of A<sub>2A</sub>R in brain cells after traumatic brain injury. ( 29449536 )
2018
23
Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury. ( 29179621 )
2018
24
Histopathological and Behavioral Assessments of Aging Effects on Stem Cell Transplants in an Experimental Traumatic Brain Injury. ( 29445958 )
2018
25
Neurometabolites Alteration in the Acute Phase of Mild Traumatic Brain Injury (mTBI): An In Vivo Proton Magnetic Resonance Spectroscopy (1H-MRS) Study. ( 29449141 )
2018
26
Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. ( 29450697 )
2018
27
Startle suppression after mild traumatic brain injury is associated with an increase in pro-inflammatory cytokines, reactive gliosis and neuronal loss in the caudal pontine reticular nucleus. ( 28089558 )
2017
28
Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. ( 28366792 )
2017
29
Long term neurobehavioral symptoms and return to productivity in Operation Enduring Freedom/Operation Iraqi Freedom Veterans with and without traumatic brain injury. ( 28088381 )
2017
30
Prevalence of persistent vegetative state in patients with severe traumatic brain injury and its trend during the past four decades: A meta-analysis. ( 27814303 )
2017
31
Tau protein (MAPT) as a possible biochemical marker of traumatic brain injury in postmortem examination. ( 28942078 )
2017
32
Outcome prediction in traumatic brain injury: Is it a "Holy Grail?" ( 28084246 )
2017
33
Serum insulin-like growth factor-I levels are associated with improved white matter recovery after traumatic brain injury. ( 28574152 )
2017
34
The effect of concussion or mild traumatic brain injury on academic outcomes: A systematic review. ( 28084891 )
2017
35
Traumatic Brain Injury in Adolescents: Incidence and Correlates. ( 28942813 )
2017
36
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. ( 28503629 )
2017
37
Paediatric traumatic brain injury: prognostic insights and outlooks. ( 28938340 )
2017
38
Transcranial ultrasound stimulation promotes brain-derived neurotrophic factor and reduces apoptosis in a mouse model of traumatic brain injury. ( 28939348 )
2017
39
Cocaine Abuse, Traumatic Brain Injury, and Preexisting Brain Lesions as Risk Factors for Bupropion-Associated Psychosis. ( 28590371 )
2017
40
Early neurological deterioration in older adults with traumatic brain injury. ( 28082072 )
2017
41
Epidemiology, Management, and Functional Outcomes of Traumatic Brain Injury in sub-Saharan Africa. ( 28943422 )
2017
42
The research progress of mesenchymal stem cells in the treatment of Traumatic brain injury. ( 28944949 )
2017
43
Protective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear Factor-I_B-related Inflammation during Traumatic Brain Injury in Mice. ( 28091411 )
2017
44
The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury. ( 29176798 )
2017
45
Intracranial Hypotension Following Traumatic Brain Injury: A Diagnostic and Therapeutic Challenge. ( 28624560 )
2017
46
Inflammation in epileptogenesis after traumatic brain injury. ( 28086980 )
2017
47
Hyperbaric oxygen promotes neural stem cell proliferation by activating vascular endothelial growth factor/extracellular signal-regulated kinase signaling after traumatic brain injury. ( 28953090 )
2017
48
H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury. ( 28419114 )
2017
49
RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients. ( 28340601 )
2017
50
Apolipoprotein E epsilon 4 (APOE-I/4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury. ( 28948085 )
2017

Variations for Traumatic Brain Injury

Expression for Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for Traumatic Brain Injury

GO Terms for Traumatic Brain Injury

Cellular components related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.35 APOE ENO2 MBP S100B UCHL1
2 myelin sheath GO:0043209 8.92 ENO2 GFAP MBP UCHL1

Biological processes related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.77 CASP3 HIF1A IGF1 IL10 IL6
2 response to drug GO:0042493 9.76 CASP3 COMT DRD2 IL10
3 axonogenesis GO:0007409 9.67 DRD2 S100B UCHL1
4 positive regulation of nitric-oxide synthase activity GO:0051000 9.51 APOE HIF1A
5 negative regulation of B cell proliferation GO:0030889 9.48 CASP3 IL10
6 regulation of gene expression GO:0010468 9.46 APOE HIF1A IGF1 IL10
7 dopamine metabolic process GO:0042417 9.43 COMT DRD2
8 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.4 IL10 MBP
9 axonal transport of mitochondrion GO:0019896 9.32 HIF1A UCHL1
10 neuron projection regeneration GO:0031102 9.26 APOE GFAP
11 response to inactivity GO:0014854 8.96 DRD2 IL10
12 response to glucocorticoid GO:0051384 8.92 CASP3 IL10 IL6 S100B

Molecular functions related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 APOE AQP4 CASP3 COMT DRD2 ENO2
2 tau protein binding GO:0048156 9.16 APOE S100B
3 growth factor activity GO:0008083 8.92 BDNF IGF1 IL10 IL6

Sources for Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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