MCID: TRM010
MIFTS: 53

Traumatic Brain Injury malady

Neuronal diseases category
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Summaries for Traumatic Brain Injury

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Sources:
34MedlinePlus, 4CDC, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Traumatic brain injury (tbi) happens when a bump, blow, jolt, or other head injury causes damage to the brain. every year, millions of people in the u.s. suffer brain injuries. more than half are bad enough that people must go to the hospital. the worst injuries can lead to permanent brain damage or death. half of all tbis are from motor vehicle accidents. military personnel in combat zones are also at risk. symptoms of a tbi may not appear until days or weeks following the injury. a concussion is the mildest type. it can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. people with a moderate or severe tbi may have those, plus other symptoms: a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures inability to awaken from sleep slurred speech weakness or numbness in the arms and legs dilated eye pupils health care professionals use a neurological exam and imaging tests to assess tbi. serious traumatic brain injuries need emergency treatment. treatment and outcome depend on how severe the injury is. tbi can cause a wide range of changes affecting thinking, sensation, language, or emotions. tbi can be associated with post-traumatic stress disorder. people with severe injuries usually need rehabilitation. nih: national institutes of neurological disorders and stroke

MalaCards: Traumatic Brain Injury is related to brain edema and schizophrenia. An important gene associated with Traumatic Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and A-beta Uptake and Degradation. The compounds l-trans-pyrrolidine-2,4-dicarboxylic acid and dl-threo-beta-benzyloxyaspartate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are vision/eye and behavior/neurological.

CDC:4 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. In 2010 2.5 million TBIs occured either as an isolated injury or along with other injuries.1

NINDS:44 Traumatic brain injury (TBI), a form of

Wikipedia:65 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force... more...

Aliases & Classifications for Traumatic Brain Injury

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Sources:
44NINDS, 34MedlinePlus, 31LifeMap Discovery™
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

traumatic brain injury 44 34 31


Related Diseases for Traumatic Brain Injury

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to traumatic brain injury

Symptoms for Traumatic Brain Injury

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Drugs & Therapeutics for Traumatic Brain Injury

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

Search ClinicalTrials for Traumatic Brain Injury

Search NIH Clinical Center for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119

Genetic Tests for Traumatic Brain Injury

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Anatomical Context for Traumatic Brain Injury

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Traumatic Brain Injury:

33
Brain, Testes, Eye, Bone, Pituitary, Cortex, Bone marrow, Heart, Prefrontal cortex, Endothelial, Spinal cord, Smooth muscle, Monocytes, Hypothalamus, T cells, Myeloid, Thyroid, Liver, Lung, Kidney, Medulla oblongata

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Traumatic Brain Injury or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Traumatic Brain Injury:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9SLC1A3, SLC1A1, MIP, APOE, GFAP
2MP:00053867.5SLC1A2, GFAP, APOE, ACE, S100B, SLC1A1
3MP:00053767.1CYSLTR2, GFAP, APOE, ACE, SLC1A1, SLC1A7

Publications for Traumatic Brain Injury

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Sources:
52PubMed
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Articles related to Traumatic Brain Injury:

(show top 50)    (show all 1049)
idTitleAuthorsYear
1
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is neuroprotective in experimental traumatic brain injury. (24392832)
2014
2
Discharge Planning Difficulties for Patients With Traumatic Brain Injury: Unique Funding Options. (24413072)
2014
3
Blood-brain barrier and traumatic brain injury. (24327344)
2014
4
Saccadic eye movements in mild traumatic brain injury: a pilot study. (24384339)
2014
5
Understanding practice: the factors that influence management of mild traumatic brain injury in the emergency department-a qualitative study using the Theoretical Domains Framework. (24418161)
2014
6
High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4. (24166800)
2014
7
Preliminary examination of the impact of traumatic brain injury and posttraumatic stress disorder on self-regulated learning and academic achievement among military service members enrolled in postsecondary education. (23982790)
2014
8
Risk and Mortality of Traumatic Brain Injury in Stroke Patients: Two Nationwide Cohort Studies. (24263175)
2013
9
Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-I+. (24312187)
2013
10
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
11
Emerging pharmacological agents to improve survival from traumatic brain injury. (24205899)
2013
12
Anaesthesiologist-provided prehospital airway management in patients with traumatic brain injury: an observational study. (24368407)
2013
13
Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. (24102309)
2013
14
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
15
Optimization of the pattern visual evoked potential (VEP) in the visually-normal and mild traumatic brain injury (mTBI) populations. (24111626)
2013
16
Quality of life after traumatic brain injury: Finnish experience of the QOLIBRI in residential rehabilitation. (24002322)
2013
17
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
18
The negative impact of traumatic brain injury (TBI) on bone in a mouse model. (24295038)
2013
19
Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury. (24002317)
2013
20
Hypernatremia in patients with severe traumatic brain injury: a systematic review. (24196399)
2013
21
Micronutrients in brain function, and traumatic brain injury. (24047958)
2013
22
Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? (23546937)
2013
23
Comparison of error-based and errorless learning for people with severe traumatic brain injury: study protocol for a randomized control trial. (24192067)
2013
24
Life satisfaction 6-15 years after a traumatic brain injury. (23995834)
2013
25
A systematic review of psychosocial outcomes within 2 years of paediatric traumatic brain injury in a school-aged population. (24020439)
2013
26
Neurocognitive function differentiation from the effect of psychopathologic symptoms in the disability evaluation of patients with mild traumatic brain injury. (24379945)
2013
27
Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury. (23198799)
2013
28
Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and P38 MAPK signalling pathway. (24131109)
2013
29
Health-related quality of life 12 months after severe traumatic brain injury: a prospective nationwide cohort study. (24002315)
2013
30
Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: A meta-analysis. (24360821)
2013
31
Motor rehabilitation in stroke and traumatic brain injury: stimulating and intense. (24141528)
2013
32
Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease. (22543850)
2012
33
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
34
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
35
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
36
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
37
The association between apolipoprotein E and traumatic brain injury severity and functional outcome in a rehabilitation sample. (21651315)
2011
38
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
39
Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. (20050894)
2010
40
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
41
Severe traumatic brain injury complicated by status asthmaticus: favorable neurological outcome despite excessive hypercapnia. (16612314)
2006
42
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
43
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
44
Lesional expression of RhoA and RhoB following traumatic brain injury in humans. (15253798)
2004
45
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. (12854754)
2003
46
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. (11777556)
2002
47
S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. (11393252)
2001
48
Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. (10701532)
2000
49
Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (9585713)
1998
50
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. (9257663)
1997

Variations for Traumatic Brain Injury

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Expression for genes affiliated with Traumatic Brain Injury

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for genes affiliated with Traumatic Brain Injury

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 30KEGG, 53QIAGEN, 12EMD Millipore, 5Cell Signaling Technology
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Pathways related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0SLC1A3, SLC1A2
29.9ACE, APOE
3
Show member pathways
9.7S100B, GFAP
4
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.7SLC1A2, SLC1A3, SLC1A1
5
Show member pathways
9.7SLC1A2, SLC1A3, SLC1A1
6
Show member pathways
8.8SLC1A6, SLC1A7, SLC1A1
78.7SLC1A2, SLC1A3, SLC1A1, S100B, APOE, GFAP
8
Show member pathways
8.3SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
9
Show member pathways
8.3SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
10
Show member pathways
7.9MIP, SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Compounds for genes affiliated with Traumatic Brain Injury

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1l-trans-pyrrolidine-2,4-dicarboxylic acid4510.3SLC1A2, SLC1A3
2dl-threo-beta-benzyloxyaspartate4510.3SLC1A3, SLC1A2
3threo-beta-hydroxyaspartate4510.3SLC1A3, SLC1A1
4[3h](2s,4r)-4-methylglutamate2910.3SLC1A2, SLC1A3
5edss4510.2APOE, S100B
6dihydrokainate45 2911.1SLC1A3, SLC1A2, SLC1A1
7eosin4510.0GFAP, S100B
8s 1004510.0GFAP, S100B
9sele4510.0APOE, ACE
10threo-3-methylglutamate299.9SLC1A2, SLC1A6
112,3-cyclic nucleotide459.9GFAP, S100B
12reticulin459.7GFAP, S100B
13dbc-amp459.6GFAP, SLC1A3, SLC1A2, S100B
14inositol459.5SLC1A2, SLC1A3, GFAP
15acetylcholine45 51 29 24 1113.5APOE, GFAP, ACE, S100B
16kainate45 2910.4APOE, SLC1A2, SLC1A3, SLC1A1, GFAP
17bromodeoxyuridine459.4GFAP, S100B, AIF1
18dopamine45 29 24 1112.4GFAP, APOE, SLC1A2, S100B
19gaba459.4SLC1A3, SLC1A1, S100B, GFAP, SLC1A2
20lactate459.3S100B, MIP, GFAP, SLC1A2
21hydrogen45 2410.2MIP, SLC1A1, CYSLTR2, S100B
22potassium45 24 1111.2GFAP, ACE, S100B, MIP, SLC1A1
23glutamine459.1S100B, SLC1A3, APOE, GFAP, SLC1A2, SLC1A1
24alanine459.1S100B, SLC1A1, SLC1A3, SLC1A2, APOE, GFAP
25adenylate459.1SLC1A3, S100B, GFAP, SLC1A2, CYSLTR2
26serine459.0SLC1A1, S100B, APOE, GFAP, SLC1A2, SLC1A3
27creatinine458.9APOE, ACE, S100B, GFAP
28vegf458.9APOE, S100B, GFAP, MIP, CYSLTR2
29nitric oxide45 24 1110.8CYSLTR2, SLC1A2, SLC1A3, S100B, ACE, MIP
30oxygen45 249.8CYSLTR2, GFAP, MIP, S100B, SLC1A2
31atp45 299.8CYSLTR2, GFAP, MIP, SLC1A3, S100B
32dihydrokainic acid618.7SLC1A1, SLC1A3, SLC1A6, SLC1A2, SLC1A7
33cysteine458.7GFAP, APOE, MIP, S100B, SLC1A2, SLC1A3
34tfb-tboa618.7SLC1A3, SLC1A2, SLC1A6, SLC1A7, SLC1A1
35l-trans-2,4-pdc618.7SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
36[3h]etb-tboa298.7SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
37[3h]l-aspartic acid298.7SLC1A6, SLC1A2, SLC1A1, SLC1A7, SLC1A3
38way 213613618.7SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
39dl-tboa61 299.7SLC1A1, SLC1A7, SLC1A2, SLC1A3, SLC1A6
40[3h]d-aspartic acid298.7SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
41glucose458.7ACE, GFAP, SLC1A2, SLC1A3, SLC1A1, S100B
42l-glutamic acid29 24 1110.7SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
43arginine458.7CYSLTR2, GFAP, APOE, MIP, S100B, SLC1A2
44nmda45 299.6SLC1A1, GFAP, SLC1A2, SLC1A3, SLC1A7, APOE
45aspartate458.5SLC1A6, GFAP, APOE, S100B, SLC1A3, SLC1A1
46lipid458.4ACE, MIP, SLC1A2, APOE, GFAP, CYSLTR2
47chloride458.3SLC1A6, SLC1A3, SLC1A7, SLC1A2, MIP, SLC1A1
48sodium45 249.0MIP, ACE, SLC1A3, SLC1A6, SLC1A2, SLC1A1
49calcium45 51 24 1110.6SLC1A2, SLC1A1, AIF1, ACE, S100B, CAPNS2
50glutamate457.3MIP, GFAP, APOE, S100B, SLC1A1, SLC1A7

GO Terms for genes affiliated with Traumatic Brain Injury

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Sources:
16Gene Ontology
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Cellular components related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.6SLC1A3, S100B, APOE
2membraneGO:0160208.4GFAP, SLC1A1, SLC1A3, SLC1A6, SLC1A2
3plasma membraneGO:0058866.2SLC1A2, CYSLTR2, APOE, MIP, ACE, CAPNS2

Biological processes related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1D-aspartate importGO:0707799.9SLC1A2, SLC1A3, SLC1A1
2L-glutamate importGO:0519389.9SLC1A2, SLC1A3, SLC1A1
3long-term synaptic potentiationGO:0602919.7S100B, GFAP
4response to woundingGO:0096119.6GFAP, SLC1A3, SLC1A2
5regulation of neuronal synaptic plasticityGO:0481689.6S100B, APOE
6L-glutamate transportGO:0158139.0SLC1A6, SLC1A7
7synaptic transmissionGO:0072689.0SLC1A1, SLC1A3, SLC1A6, SLC1A2
8ion transportGO:0068118.4SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
9transmembrane transportGO:0550858.0MIP, SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Molecular functions related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.0SLC1A3, SLC1A1
2glutamate:sodium symporter activityGO:0155019.9SLC1A2, SLC1A1
3tau protein bindingGO:0481569.6S100B, APOE
4sodium:dicarboxylate symporter activityGO:0171538.3SLC1A7, SLC1A3, SLC1A6, SLC1A2, SLC1A1
5L-glutamate transmembrane transporter activityGO:0053138.3SLC1A2, SLC1A1, SLC1A7, SLC1A3, SLC1A6

Products for genes affiliated with Traumatic Brain Injury

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  • Antibodies
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Sources for Traumatic Brain Injury

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet