MCID: TRM010
MIFTS: 43

Traumatic Brain Injury malady

Neuronal diseases category

Summaries for Traumatic Brain Injury

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Sources:
33MedlinePlus, 3CDC, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Traumatic brain injury (tbi) happens when a bump, blow, jolt, or other head injury causes damage to the brain. every year, millions of people in the u.s. suffer brain injuries. more than half are bad enough that people must go to the hospital. the worst injuries can lead to permanent brain damage or death. half of all tbis are from motor vehicle accidents. military personnel in combat zones are also at risk. symptoms of a tbi may not appear until days or weeks following the injury. a concussion is the mildest type. it can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. people with a moderate or severe tbi may have those, plus other symptoms: a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures inability to awaken from sleep slurred speech weakness or numbness in the arms and legs dilated eye pupils health care professionals use a neurological exam and imaging tests to assess tbi. serious traumatic brain injuries need emergency treatment. treatment and outcome depend on how severe the injury is. tbi can cause a wide range of changes affecting thinking, sensation, language, or emotions. tbi can be associated with post-traumatic stress disorder. people with severe injuries usually need rehabilitation. nih: national institutes of neurological disorders and stroke

MalaCards: Traumatic Brain Injury is related to brain edema and alzheimer's disease. An important gene associated with Traumatic Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neuroscience and SLC-mediated transmembrane transport. The compounds glutamate and cysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are behavior/neurological and cellular.

CDC:3 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. In 2010 2.5 million TBIs occured either as an isolated injury or along with other injuries.1

NINDS:43 Traumatic brain injury (TBI), a form of

Wikipedia:63 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force... more...

Aliases & Classifications for Traumatic Brain Injury

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Sources:
43NINDS, 33MedlinePlus, 30LifeMap Discovery™
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

traumatic brain injury 43 33 30


Related Diseases for Traumatic Brain Injury

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Traumatic Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1brain edema31.4GFAP, AQP4, MIP
2alzheimer's disease30.8S100B, AQP4, NEFH, UCHL1, GFAP, SLC1A2
3schizophrenia30.7SLC1A3, TPPP3, AQP4, SLC1A1, SLC1A2, S100B
4dementia30.6CX3CL1, APOE, GFAP, SLC1A2, SLC1A3, TPPP3
5ischemia30.5AIF1, MIP, NGB, AQP4, SLC1A3, SLC1A1
6brain cancer30.5ENO2, GFAP, AQP4, MIP
7hydrocephalus30.4AQP4
8parkinson's disease30.4APOE
9encephalitis30.1TPPP3, AQP4, GFAP, CX3CL1
10vascular disease30.1ENO2, GFAP, SLC1A2
11migraine30.1SLC1A3
12cerebral amyloid angiopathy30.1APOE
13neuropathy30.1NEFH
14frontotemporal dementia30.1APOE
15retinoblastoma30.1GFAP, ENO2
16cerebritis11.0
17hypopituitarism10.9
18neuronitis10.9
19hypertension10.8
20intracranial hypertension10.8
21brain disease10.7
22post-traumatic stress disorder10.7
23diabetes insipidus10.6
24alexithymia10.6
25psychotic disorder10.5
26acute stress disorder10.5
27alcohol abuse10.4
28learning disability10.4
29neuroleptic malignant syndrome10.3
30head injury10.3
31attention deficit hyperactivity disorder10.2
32bone fracture10.2
33locked-in syndrome10.2
34agnosia10.2
35anxiety disorder10.2
36tauopathy10.2
37moderate and severe traumatic brain injury10.2
38paranoid schizophrenia10.1
39pure red-cell aplasia10.1
40major depressive disorder10.1
41status epilepticus10.1
42diabetic ketoacidosis10.1
43narcolepsy10.1
44ankylosis10.1
45brain compression10.1
46pseudotumor cerebri10.1
47choroiditis10.1
48sensorineural hearing loss10.1
49adult respiratory distress syndrome10.1
50superior mesenteric artery syndrome10.1

Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to traumatic brain injury

Clinical Features for Traumatic Brain Injury

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Drugs & Therapeutics for Traumatic Brain Injury

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Traumatic Brain Injury

Drug clinical trials:

Search ClinicalTrials for Traumatic Brain Injury

Search NIH Clinical Center for Traumatic Brain Injury

Search CenterWatch for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119

Genetic Tests for Traumatic Brain Injury

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Anatomical Context for Traumatic Brain Injury

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Traumatic Brain Injury:

32
Brain, Eye, Testes, Bone, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Traumatic Brain Injury or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Traumatic Brain Injury:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.1AQP4, S100B, UCHL1, APOE, NEFH, NGB
2MP:000538410.9NEFH, CX3CL1, GFAP, SLC1A2, SLC1A1, SLC1A3
3MP:000363110.8UCHL1, APOE, NEFH, CX3CL1, GFAP, SLC1A2
4MP:000537610.6GFAP, CX3CL1, CYSLTR2, APOE, SLC1A7, SLC1A2

Publications for Traumatic Brain Injury

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Genetic Variations for Traumatic Brain Injury

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Expression for genes affiliated with Traumatic Brain Injury

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for genes affiliated with Traumatic Brain Injury

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Sources:
4Cell Signaling Technology, 53Reactome, 29KEGG, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Traumatic Brain Injury

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4411.4SLC1A3, ENO2, SLC1A6, SLC1A1, SLC1A7, GFAP
2cysteine4411.4GFAP, SLC1A2, SLC1A3, AQP4, CX3CL1, UCHL1
3sodium44 2412.3SLC1A2, SLC1A1, MIP, SLC1A6, SLC1A3, SLC1A7
4chloride4411.2SLC1A2, AQP4, ENO2, SLC1A6, SLC1A3, SLC1A1
5aspartate4411.2S100B, APOE, GFAP, SLC1A2, SLC1A3, ENO2
6calcium44 49 11 2414.2CYSLTR2, MIP, ENO2, ACE, SLC1A1, SLC1A2
7lipid4411.2CYSLTR2, GFAP, ACE, S100B, ENO2, APOE
8serine4411.2S100B, UCHL1, NEFH, CX3CL1, GFAP, SLC1A2
9potassium44 11 2413.2ENO2, GFAP, MIP, S100B, AQP4, SLC1A1
10nitric oxide44 11 2413.2S100B, MIP, NGB, CYSLTR2, SLC1A2, SLC1A3
11glutamine4411.2SLC1A3, SLC1A1, SLC1A2, GFAP, APOE, S100B
12nmda44 2812.2GFAP, SLC1A7, APOE, SLC1A1, SLC1A2, SLC1A3
13dopamine44 28 11 2414.2S100B, UCHL1, APOE, GFAP, SLC1A2, ENO2
14dl-tboa59 2812.1SLC1A7, SLC1A1, SLC1A2, SLC1A6, SLC1A3
15tfb-tboa5911.1SLC1A7, SLC1A3, SLC1A1, SLC1A6, SLC1A2
16superoxide44 2412.1UCHL1, ENO2, SLC1A3, SLC1A2, GFAP, NGB
17way 2136135911.1SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
18l-trans-2,4-pdc5911.1SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
19dihydrokainic acid5911.1SLC1A7, SLC1A3, SLC1A6, SLC1A1, SLC1A2
20gaba4411.1SLC1A2, ENO2, SLC1A3, SLC1A1, S100B, GFAP
21[3h]l-aspartic acid2811.1SLC1A1, SLC1A6, SLC1A3, SLC1A7, SLC1A2
22[3h]etb-tboa2811.1SLC1A2, SLC1A3, SLC1A6, SLC1A1, SLC1A7
23glucose4411.1SLC1A2, SLC1A3, SLC1A1, GFAP, NGB, MIP
24[3h]d-aspartic acid2811.1SLC1A3, SLC1A6, SLC1A2, SLC1A1, SLC1A7
25alanine4411.1SLC1A3, SLC1A1, ENO2, SLC1A2, GFAP, APOE
26dbc-amp4411.1ENO2, S100B, GFAP, SLC1A3, SLC1A2
27l-glutamic acid28 11 2413.1SLC1A2, SLC1A1, SLC1A6, SLC1A3, SLC1A7
28kainate44 2812.1APOE, GFAP, SLC1A3, SLC1A2, SLC1A1
29adenylate4411.1ENO2, GFAP, CYSLTR2, S100B, SLC1A2, SLC1A3
30dihydrokainate44 2812.0SLC1A1, SLC1A2, SLC1A3
31oxygen44 2412.0SLC1A2, CYSLTR2, ENO2, NGB, S100B, GFAP
32edss4411.0ENO2, APOE, S100B
33acetylcholine44 49 28 11 2415.0S100B, APOE, ENO2, ACE, GFAP
34s 1004411.0GFAP, S100B, ENO2
35paraffin4410.9NEFH, S100B, ENO2, GFAP, APOE
36bromodeoxyuridine4410.9GFAP, S100B, ENO2, AIF1
37threo-3-methylglutamate2810.9SLC1A2, SLC1A6
38dl-threo-beta-benzyloxyaspartate4410.9SLC1A3, SLC1A2
39vegf4410.9GFAP, S100B, APOE, CYSLTR2, ENO2, MIP
40l-trans-pyrrolidine-2,4-dicarboxylic acid4410.9SLC1A3, SLC1A2
41iron44 2411.9NGB, ENO2, GFAP, S100B, SLC1A2
42threo-beta-hydroxyaspartate4410.9SLC1A3, SLC1A1
43mannitol44 1111.8AQP4, S100B
44spec-t4410.8GFAP, APOE, ENO2
45arginine4410.8S100B, MIP, CYSLTR2, SLC1A2, GFAP, APOE
46acth4410.8ENO2, GFAP, CYSLTR2, S100B
47tyrosine4410.7GFAP, TPPP3, ENO2, CYSLTR2, MIP, NEFH
48lactate4410.7MIP, SLC1A2, S100B, ENO2, GFAP
49creatinine4410.7APOE, GFAP, ACE, ENO2, S100B
50[3h](2s,4r)-4-methylglutamate2810.3SLC1A3, SLC1A2

GO Terms for genes affiliated with Traumatic Brain Injury

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16Gene Ontology
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Cellular components related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.7AQP4, UCHL1, APOE, MIP, CYSLTR2, CX3CL1
2neuronal cell bodyGO:04302510.7SLC1A3, APOE, UCHL1, S100B

Biological processes related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:05508510.8AQP4, MIP, SLC1A7, SLC1A2, SLC1A1, SLC1A6
2D-aspartate importGO:07077910.8SLC1A2, SLC1A1, SLC1A3
3L-glutamate importGO:05193810.7SLC1A2, SLC1A1, SLC1A3
4ion transportGO:00681110.7SLC1A6, SLC1A1, SLC1A3, SLC1A2, SLC1A7
5regulation of neuronal synaptic plasticityGO:04816810.6S100B, APOE
6response to woundingGO:00961110.5SLC1A3, GFAP, SLC1A2
7L-glutamate transportGO:01581310.3SLC1A7, SLC1A6

Molecular functions related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715310.8SLC1A2, SLC1A1, SLC1A6, SLC1A3, SLC1A7
2L-glutamate transmembrane transporter activityGO:00531310.7SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
3glutamate bindingGO:01659510.6SLC1A3, SLC1A1
4glutamate:sodium symporter activityGO:01550110.5SLC1A1, SLC1A2
5tau protein bindingGO:04815610.3APOE, S100B

Products for genes affiliated with Traumatic Brain Injury

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Traumatic Brain Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet