Traumatic Brain Injury malady

MedlinePlus: Traumatic brain injury happens when a bump, blow, jolt, or other head injury causes damage to the brain. every year, millions of people in the u.s. suffer brain injuries. more than half are bad enough that people must go to the hospital. the worst injuries can lead to permanent brain damage or death. half of all traumatic brain injuries (tbis) are due to motor vehicle accidents. military personnel are also at risk. symptoms of a tbi may not appear until days or weeks following the injury. serious traumatic brain injuries need emergency treatment. treatment and outcome depend on the injury. tbi can cause a wide range of changes affecting thinking, sensation, language, or emotions. tbi can be associated with post-traumatic stress disorder. people with severe injuries usually need rehabilitation.²³

MalaCards: Traumatic Brain Injury is related to hypopituitarism and neuroaxonal dystrophy. An important gene associated with Traumatic Brain Injury is SLC1A6 (solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Neuroscience. The compounds glucose and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

CDC: Ask the Expert: Hear from CDC’s Dr. Julie Gilchrist in this new video created in partnership with the Be Smart. Be Well campaign at:²

NINDS: Traumatic brain injury (TBI), a form of³¹

Wikipedia: Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force...⁴⁴ more...

traumatic brain injury 31 23

Diseases related to traumatic brain injury by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1002)

id	Related Disease	Score	Top Affiliating Genes
1	hypopituitarism	31.0	LEP, INS, IL6, IGF1, GH1, GHRH
2	neuroaxonal dystrophy	30.9	APP, IGF1, SNCA, RPS27A, NGF
3	schizophrenia	30.1	BMP6, MTHFR, IL1B, IL1RN, ANKK1, MAOA
4	head injury	30.0	BDNF, CKB, CHRM1, S100B, INS, IL18
5	cerebral amyloid angiopathy	30.0	MME, MMP9, IL1A, IL6, AQP4, APOE
6	cerebral hemorrhage	28.4	MTHFR, S100B, INS, IL1B, IL1RN, IL6
7	septic shock	28.4	SERPINC1, IL10, IL1A, IL1B, IL1RN, IL6
8	neutropenia	28.3	BCL2, S100B, IL10, IL1A, IL1B, IL1RN
9	parkinson's disease	28.3	PARP1, BDNF, UCHL1, XIAP, APOE, APP
10	growth hormone deficiency	27.2	RETN, LEP, MMP9, INS, IL6, APOE
11	neurodegenerative disease	26.6	SERPINI1, PARP1, BDNF, BCL2, CHRM1, UCHL1
12	brain injury	25.7	RETN, SERPINC1, SERPINI1, VEGFA, VCAN, BMP2
13	cerebral infarction	24.2	SERPINC1, VEGFA, MTHFR, MMP3, MMP9, INS
14	seizures	23.6	SERPINI1, VEGFA, PARP1, BDNF, SCN8A, BBC3
15	dementia	21.3	SERPINC1, SERPINI1, VEGFA, BDNF, BCL2, CHRM1
16	neuronitis	20.6	RETN, SERPINC1, SERPINI1, VEGFA, VCAN, BMP2
17	cerebritis	18.6	SERPINC1, SERPINI1, VEGFA, VCAN, BMP6, PARP1
18	alzheimer's disease	18.5	SERPINC1, SERPINI1, VEGFA, BMP6, PARP1, BDKRB2
19	hypoxia	16.8	VEGFA, BMP2, BMP6, PARP1, BDKRB2, BDNF
20	ischemia	16.3	RETN, SERPINC1, SERPINI1, VEGFA, PARP1, BDKRB2
21	temporal lobe epilepsy	14.2	BDNF, AQP4, HTR1A, GFAP, TSPO, SLC1A3
22	semantic dementia	14.0	GRN, APOE, RPS27A, TARDBP
23	cognitive disease	14.0	CHRM1, APOE, APP, MAOA, HTR1A, COMT
24	pineocytoma	14.0	S100B, MBP, ENO2, GFAP, SYP
25	creutzfeldt-jakob syndrome	14.0	S100B, APOE, APP, ENO2, TPPP3, SNCA
26	hemimegalencephaly	14.0	CREB1, NGF, SLC1A3, SLC1A1, SLC1A2
27	ossifying fibromyxoid tumor	14.0	S100A1, S100B, MME, MBP, SLC1A6
28	binswanger's disease	13.9	APOE, APP, CRH, ACHE
29	amyloid tumor	13.9	BACE1, MME, APOE, APP, RPS27A, ACHE
30	normal pressure hydrocephalus	13.9	BDNF, APOE, PTGDS, ACE, GFAP
31	neurilemmoma	13.9	BMP2, S100A1, S100B, MBP, ENO2, SNCA
32	amelanotic melanoma	13.9	PARP1, S100A1, S100B, DRD2, CYCS
33	tauopathy	13.9	SERPINI1, CDKN3, GRN, APP, SNCA, RPS27A
34	dentatorubral-pallidoluysian atrophy	13.9	CASP3, CACNA1A, CREB1, RPS27A, GFAP, SLC1A3
35	spinocerebellar ataxia type 3	13.8	S100B, APOE, ENO2, HTR1A, CACNA1A, SNCA
36	social phobia	13.8	MAOA, HTR1A, DRD2, COMT, SLC6A4
37	aphasia	13.8	GRN, APOE, APP, SNCA, PLAT, RPS27A
38	hereditary cerebral hemorrhage with amyloidosis	13.8	IL6, APP, RPS27A, AGRN, GFAP, SYP
39	antisocial personality disorder	13.8	ANKK1, MAOA, HTR2A, DRD2, SLC6A4
40	generalized anxiety disorder	13.8	MAOA, HTR1A, HTR2A, TSPO, SLC6A4
41	endogenous depression	13.8	BDNF, HTR1A, CRH, SLC6A4
42	neuroendocrine tumor	13.8	ENO2, GH1, DRD2, TAC1, SYP, POMC
43	neuroleptic malignant syndrome	13.8	ANKK1, HTR1A, HTR2A, DRD2, POMC, NPPB
44	neurotic disorder	13.8	BDNF, MAOA, HTR1A, HTR2A, DRD2, COMT
45	rem sleep behavior disorder	13.7	SNCA, RPS27A, ACHE, SLC6A3
46	gonadal disease	13.7	IGF1, GH1, CRH, POMC
47	novelty seeking personality	13.7	MAOA, DRD2, COMT, ACE
48	aggressive digital papillary adenocarcinoma	13.7	S100A1, MAOA, HTR1A, DRD2, COMT, TSPO
49	adrenal carcinoma	13.7	LEP, GRN, ENO2, CRH, SYP
50	opiate dependence	13.7	DRD2, CREB1, COMT, TH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to traumatic brain injury:

²²

MGI Mouse Phenotypes related to traumatic brain injury:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.7	ACVR1B, ACVR2A, GHRH, HTR2A, FASLG, AQP7
2	respiratory system phenotype	MP:0005388	10.2	ADORA1, TH, AGRN, ACVR1B, ACVR2A, ACHE
3	hematopoietic system phenotype	MP:0005397	10.0	CX3CL1, BDKRB2, BCL2, KCNN4, BBC3, TG
4	embryogenesis phenotype	MP:0005380	9.4	FDFT1, FEN1, FOS, PARP1, COMT, SERPINC1
5	taste/olfaction phenotype	MP:0005394	9.4	SLC6A3, SNCA, DRD2, TPH2, ENO2, CASP3
6	renal/urinary system phenotype	MP:0005367	9.0	COL18A1, NOS3, SNCA, SPTA1, DRD2, CASP3
7	hearing/vestibular/ear phenotype	MP:0005377	8.9	FOS, AQP4, APOE, FAS, MBP, IGF1
8	immune system phenotype	MP:0005387	8.5	FOS, MMP3, MME, P2RX4, XIAP, BBC3
9	pigmentation phenotype	MP:0001186	8.4	SPTA1, DRD2, TP53, CASP3, CCL2, FAS
10	no phenotypic analysis	MP:0003012	8.4	CACNA1A, TP53, DRD2, SNCA, ACHE, TARDBP
11	integument phenotype	MP:0010771	7.7	BCL2, BDNF, PARP1, ADORA1, SLC6A4, SLC6A3
12	liver/biliary system phenotype	MP:0005370	7.6	EPO, IL6, FEN1, INS, VEGFA, SERPINC1
13	reproductive system phenotype	MP:0005389	7.6	ACHE, COMT, SNCA, SPTA1, DRD2, GHRH
14	normal phenotype	MP:0002873	7.4	NOS1, NFE2L2, HIF1A, AGRN, VCAN, TH
15	adipose tissue phenotype	MP:0005375	7.2	POMC, ADCYAP1, IL6, IL18, FEN1, DRD2
16	digestive/alimentary phenotype	MP:0005381	7.1	ACVR2A, APOE, AQP4, IL18, FEN1, INS
17	nervous system phenotype	MP:0003631	6.7	CREB1, SNCA, SPTA1, SPTAN1, CYCS, DRD2
18	tumorigenesis	MP:0002006	6.5	POMC, CASP1, TP53, DRD2, PTGDS, COL18A1
19	mortality/aging	MP:0010768	6.0	ADCYAP1, SLC1A2, SLC6A4, SLC6A3, DCX, TARDBP
20	muscle phenotype	MP:0005369	6.0	S100A1, XIAP, BACE1, LEP, SCN8A, KCNN4
21	skeleton phenotype	MP:0005390	5.7	MTHFR, LEP, SCN8A, KDR, BDKRB2, BMP6
22	behavior/neurological phenotype	MP:0005386	5.1	APBB1, CHRM1, LEP, CKB, SCN8A, KDR
23	vision/eye phenotype	MP:0005391	4.5	SREBF2, TP53, CASP3, CASP7, F3, CCL2
24	growth/size phenotype	MP:0005378	4.4	ADCYAP1, SLC1A2, SLC6A4, SLC6A3, DCX, TARDBP
25	cellular phenotype	MP:0005384	3.3	ACVR2A, ACE, RHOB, NFE2L2, NOS3, NOS1
26	cardiovascular system phenotype	MP:0005385	2.8	SPTA1, CASP7, F2, HTR1A, F3, IGF1
27	homeostasis/metabolism phenotype	MP:0005376	2.3	TG, TH, GFAP, HIF1A, ACVR2A, ACHE

Articles related to traumatic brain injury:

(show top 50)    (show all 215)

id	Title	Authors	Year	Affiliating Genes
1	Neuroprotection against traumatic brain injury by a p eptide derived from the collapsin response mediator protein 2 (CRMP2). (21832084)	Brittain J.M.... Khanna R.	2011	DPYSL2
2	In vivo contributions of BH3-only proteins to neurona l death following seizures, ischemia, and traumatic brain injury. (21364604)	Engel T.... Henshall D.C.	2011	BBC3
3	Ubiquitin C-terminal hydrolase is a novel biomarker i n humans for severe traumatic brain injury. (19726976)	Papa L.... Wang K.K.	2010	UCHL1
4	miR-107 regulates granulin/progranulin with implicati ons for traumatic brain injury and neurodegenerative disease. (20489155)	Wang W.X.... Nelson P.T.	2010	GRN, MIR107
5	I+II-spectrin breakdown products (SBDPs): diagnosis an d outcome in severe traumatic brain injury patients. (20408766)	Mondello S.... Hayes R.L.	2010	SPTAN1
6	Temporally resolved differential proteomic analysis of human ventricular CSF for monitoring traumatic brain injury biomarker candidates. (19263575)	Hanrieder J.... Bergquist J.	2009	CST3, TPPP3
7	Impaired expression of neuroprotective molecules in t he HIF-1alpha pathway following traumatic brain injury in aged mice. (19203226)	Anderson J.... Berman N.E.	2009	HMOX1, EPO
8	Traumatic brain injury results in disparate regions o f chondroitin sulfate proteoglycan expression that are temporally limited. (19437549)	Harris N.G.... Sutton R.L.	2009	VCAN
9	Apolipoprotein E-genotype dependent hippocampal and c ortical responses to traumatic brain injury. (19409232)	Crawford F.... Mullan M.	2009	APOE
10	Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (18698520)	McAllister T.W.... Tsongalis G.J.	2008	DRD2, ANKK1
11	Progesterone and its metabolite allopregnanolone differentially regulate hemostatic proteins after traumatic brain injury. (18628783)	Vanlandingham J.W.... Stein D.G.	2008	PLAT, SERPINI1
12	Apolipoprotein E polymorphism and gender difference in outcome after severe traumatic brain injury. (19025529)	Ost M.... Nellgard B.	2008	APOE
13	A comparison of cognitive functioning in older adults with and without traumatic brain injury. (18520426)	Ashman T.A.... Hibbard M.R.	2008	APOE
14	Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats. (18093155)	Liao Z.B.... He Z.H.	2008	EPO
15	Nerve growth factor expression correlates with severity and outcome of traumatic brain injury in children. (17881264)	Chiaretti A.... Piedimonte G.	2008	NGF
16	Effect of rosuvastatin on amnesia and disorientation after traumatic brain injury (NCT003229758). (18690806)	Tapia-Perez J.H.... Chalita-Williams J.	2008	IL6
17	Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury. (17310037)	Ponsford J.... Ng K.T.	2007	APOE
18	Cellular localization of pituitary adenylate cyclase-activating peptide (PACAP) following traumatic brain injury in humans. (17431645)	van Landeghem F.K.... von Deimling A.	2007	ADCYAP1
19	Endostatin/collagen XVIII accumulates in patients with traumatic brain injury. (16866623)	Deininger M.H.... Schluesener H.J.	2006	COL18A1
20	Detection of alphaII-spectrin and breakdown products in humans after severe traumatic brain injury. (16841024)	Cardali S.... Maugeri R.	2006	SPTAN1, SPTA1
21	Heme oxygenase 1 in cerebrospinal fluid from infants and children after severe traumatic brain injury. (16943657)	Cousar J.L.... Clark R.S.	2006	HMOX1
22	Hippocampal volume, brain atrophy, and APOE genotype after traumatic brain injury. (16966535)	Isoniemi H.... Portin R.	2006	APOE
23	Association of APOE e4 and cerebrovascular pathology in traumatic brain injury. (16484645)	Smith C.... Nicoll J.A.	2006	APOE
24	High thyroglobulin (Tg) concentrations in fatal traumatic brain injuries. (16936513)	Dressler J.... Mueller E.	2006	TG
25	Matrix metalloproteinase-3 expression profile differentiates adaptive and maladaptive synaptic plasticity induced by traumatic brain injury. (16862547)	Falo M.C.... Phillips L.L.	2006	MMP3
26	Neuroprotective efficacy of repinotan HCl, a 5-HT1A receptor agonist, in animal models of stroke and traumatic brain injury. (15674237)	Mauler F.... HorvA!th E.	2005	HTR1A
27	Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury. (16007417)	Martinez-Lucas P.... Garcia-Olmo D.	2005	TP53
28	Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. (16211562)	Zhao J.... Dash P.K.	2005	AQP4
29	Association of COMT Val158Met genotype with executive functioning following traumatic brain injury. (16387984)	Lipsky R.H.... Warden D.L.	2005	COMT
30	A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson's disease and traumatic brain injury. (15716464)	Fahrig T.... HorvA!th E.	2005	JUN
31	Ubiquitin immunoreactivity in cerebrospinal fluid aft er traumatic brain injury: clinical and experimental findings. (16003067)	Majetschak M.... Proctor K.G.	2005	RPS27A
32	Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. (15379997)	Mauler F.... Urbahns K.	2004	KCNN4, KCNN1
33	Nitric oxide in traumatic brain injury. (15193032)	Cherian L.... Robertson C.S.	2004	NOS1
34	GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. (15684648)	Pelinka L.E.... Redl H.	2004	GFAP
35	Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels. (14758155)	Dimopoulou I.... Roussos C.	2004	POMC, CRH
36	Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. (15111666)	Vos P.E.... Verbeek M.M.	2004	ENO2, GFAP
37	Proliferation and neuronal differentiation of mitotically active cells following traumatic brain injury. (14552881)	Rice A.C.... Bullock M.R.	2003	TUBB3
38	Apolipoprotein E polymorphism and outcome after closed traumatic brain injury: influence of ethnic and regional differences. (12593615)	Nathoo N.... Naidoo R.	2003	APOE
39	Association between apolipoprotein E genotype and outcome of traumatic brain injury. (14520543)	Chiang M.F.... Hu C.J.	2003	APOE
40	Serum S-100B protein as a molecular marker in severe traumatic brain injury. (14530578)	Raabe A.... Seifert V.	2003	S100B
41	Alterations in cerebrospinal fluid apolipoprotein E and amyloid beta-protein after traumatic brain injury. (14588111)	Kay A.D.... Nicoll J.A.	2003	APP, APOE
42	Significance of serum neuron-specific enolase in patients with acute traumatic brain injury. (12857514)	Guan W.... Gong D.S.	2003	ENO2
43	Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease. (11784357)	Jellinger K.A.... Litvan I.	2001	APOE
44	The duality of the inflammatory response to traumatic brain injury. (11831551)	Lenzlinger P.M.... McIntosh T.K.	2001	BMP6
45	Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. (11383749)	Sanchez Mejia R.O.... Friedlander R.M.	2001	CASP1
46	Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans. (11393251)	Lenzlinger P.M.... Kossmann T.	2001	IL2RA
47	Altered phenytoin pharmacokinetics in children with s evere, acute traumatic brain injury. (11185666)	Stowe C.D.... Phelps S.J.	2000	ALB
48	Differential effect of a dopaminergic agonist on pref rontal function in traumatic brain injury patients. (9648550)	McDowell S.... D'Esposito M.	1998	DRD2
49	Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. (8595516)	Kossmann T.... Morganti-Kossmann C.	1995	IL6
50	Induction of c-fos mRNA and protein in neurons and gl ia after traumatic brain injury: pharmacological characterization. (2106445)	Dragunow M.... Frith R.	1990	FOS

Genes related to traumatic brain injury according to GeneCards:

(show top 50)    (show all 148)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	11.1	Summaries
2	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.1	Summaries, Publications
3	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.1	Publications, Summaries
4	SLC1A7	solute carrier family 1 (glutamate transporter), member 7	11.1	Summaries
5	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	11.1	Summaries
6	MIR107	microRNA 107	11.0	Publications
7	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
8	ANKK1	ankyrin repeat and kinase domain containing 1	11.0	Publications
9	NGB	neuroglobin	11.0	Publications
10	AIF1	allograft inflammatory factor 1	11.0	Publications
11	GORASP1	golgi reassembly stacking protein 1, 65kDa	11.0	Publications
12	P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	11.0	Publications
13	BBC3	BCL2 binding component 3	11.0	Publications
14	GRN	granulin	11.0	Publications
15	AQP7	aquaporin 7	11.0	Publications
16	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
17	TM2D1	TM2 domain containing 1	11.0	Publications
18	IL18BP	interleukin 18 binding protein	11.0	Publications
19	ANGPTL4	angiopoietin-like 4	11.0	Publications
20	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	11.0	Publications
21	APOE	apolipoprotein E	11.0	Publications
22	CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1	11.0	Publications
23	CHRM1	cholinergic receptor, muscarinic 1	11.0	Publications
24	PTGDS	prostaglandin D2 synthase 21kDa (brain)	11.0	Publications
25	CKB	creatine kinase, brain	11.0	Publications
26	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
27	GFAP	glial fibrillary acidic protein	11.0	Publications
28	KCNN1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	11.0	Publications
29	SPTAN1	spectrin, alpha, non-erythrocytic 1	11.0	Publications
30	MIP	major intrinsic protein of lens fiber	11.0	Publications
31	CYSLTR2	cysteinyl leukotriene receptor 2	11.0	Publications
32	ACVR1B	activin A receptor, type IB	11.0	Publications
33	AIMP1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	11.0	Publications
34	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	11.0	Publications
35	AQP4	aquaporin 4	11.0	Publications
36	S100B	S100 calcium binding protein B	11.0	Publications
37	RHOB	ras homolog family member B	11.0	Publications
38	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
39	SREBF1	sterol regulatory element binding transcription factor 1	11.0	Publications
40	DCX	doublecortin	11.0	Publications
41	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	11.0	Publications
42	ACVR2A	activin A receptor, type IIA	11.0	Publications
43	SREBF2	sterol regulatory element binding transcription factor 2	11.0	Publications
44	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
45	GHRH	growth hormone releasing hormone	11.0	Publications
46	AGRN	agrin	11.0	Publications
47	FEN1	flap structure-specific endonuclease 1	11.0	Publications
48	FDFT1	farnesyl-diphosphate farnesyltransferase 1	11.0	Publications
49	BDKRB2	bradykinin receptor B2	11.0	Publications
50	S100A9	S100 calcium binding protein A9	11.0	Publications

Pathways related to traumatic brain injury according to GeneDecks:

(show top 50)    (show all 109)

id	Pathway	Score	Top Affiliating Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.7	CYCS
2	Neuroscience3	10.4	GFAP, NGF, CREB1, SNCA, TH, DPYSL2
3	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.3	POMC, LEP
4	RAR-Gamma-RXR-Alpha Degradation36	10.3	CX3CL1, BMP2, CSF3
5	NFAT Signaling and Lymphocyte Interactions36	10.1	BMP6, BCL2, IL1A, CCL2, CACNA1A, BMP2
6	Apoptosis and survival Caspase cascade10	10.0	XIAP, CASP3, CYCS, CASP7, IGF1, FAS
7	Apoptosis and survival_Caspase cascade41	9.9	PARP1, CASP3, XIAP, FASLG, FAS, IGF1
8	Akt Signaling36	9.9	IL2RA, IL6, CCL2, PTK2B, BMP2, IL18
9	Pathogenesis of ALS36	9.7	CASP3, SLC1A2, SLC1A1, SLC1A3, SOD1, CYCS
10	Apoptosis and survival_FAS signaling cascades41	9.5	BCL2, FASLG, XIAP, PARP1, FAS, CASP7
11	PGC1Alpha Pathway36	9.4	CREB1, PPARA, IL8, IL1B, IL1A, IL18
12	Apoptosis and survival FAS signaling cascades10	9.4	PARP1, BCL2, XIAP, FASLG, FAS, CASP7
13	Neuroactive ligand-receptor interaction20	9.3	GH1, ADORA1, PRL, TACR1, TSPO, CYSLTR1
14	Apoptosis Signaling Pathways37	9.2	TP53, CYCS, CASP3, CASP7, FAS, FASLG
15	DHA Signaling36	9.2	BCL2, BMP2, IL6, IGF1, APP, CASP7
16	Alzheimers disease20	9.2	CAPN1, APOE, CASP7, CASP3, CYCS, SNCA
17	ERK Signaling36	9.1	CSF3, CX3CL1, COL18A1, CREB1, BMP2, BMP6
18	p53 Mediated Apoptosis36	9.1	CYCS, TP53, GHRH, GH1, CASP3, IGF1
19	Mitochondrial Apoptosis36	9.0	KDR, GHRH, BDNF, GH1, BCL2, BBC3
20	Cellular Apoptosis Pathway36	9.0	BMP2, BMP6, BDNF, KDR, BBC3, IL6
21	IL-6 Pathway36	9.0	IL8, IL18, MAPK1, CCL2, CX3CL1, CSF3
22	Apoptosis20	9.0	CASP3, TP53, XIAP, NGF, IL1A, IL1B
23	Endothelin-1 Signaling Pathway36	8.9	IL18, IL1A, IL1B, IL6, MAPK1, CASP7
24	all-trans-Retinoic Acid Signaling in Brain36	8.6	IL8, IL6, CX3CL1, CSF3, BMP6, BCL2
25	14-3-3 Induced Apoptosis36	8.6	CASP7, MAPK1, IL1B, IL1A, FOS, JUN
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.5	APOE, FASLG, IL1A, FOS, JUN, IGF1
27	Immune response IL-1 signaling pathway10	8.4	EDN1, HMOX1, F3, IL8, IL6, IL1B
28	Renin-Angiotensin Pathway36	8.4	IL6, FOS, BMP2, MAPK1, ACE, PTK2B
29	MIF Mediated Glucocorticoid Regulation36	8.4	CCL2, IL1B, BMP2, BMP6, MAPK1, BCL2
30	Immune response_IL-1 signaling pathway41	8.4	HMOX1, EDN1, F3, IL8, IL6, IL1B
31	Tec Kinases Signaling36	8.3	BDNF, IGF1, GH1, CCL2, GHRH, IL8
32	PEDF Induced Signaling36	8.3	IL6, IL8, CSF3, CX3CL1, MAPK1, CCL2
33	STAT3 Pathway36	8.1	MAPK1, IL2RA, CCL2, BMP2, BMP6, CX3CL1
34	Pertussis20	8.1	IL10, CASP7, CASP3, IL1B, IL1A, MAPK1
35	PAK Pathway36	8.0	IL1A, CSF3, IL18, IL10, BCL2, CX3CL1
36	Rheumatoid arthritis20	7.9	MMP3, FOS, IL8, IL1A, IL1B, JUN
37	Molecular Mechanisms of Cancer36	7.8	TUBB3, IL6, FOS, JUN, BCL2, KDR
38	Chagas disease (American trypanosomiasis)20	7.7	JUN, IL8, FASLG, IL1B, CCL2, ACE
39	Pathways in cancer20	7.6	FOS, FAS, MAPK1, CASP3, MMP9, JUN
40	MAPK Signaling36	7.5	PTK2B, GHRH, BMP2, GH1, IGF1, MAPK1
41	Influenza A20	7.5	CYCS, CASP1, JUN, IL18, IL1A, IL6
42	Glucocorticoid Receptor Signaling36	7.5	IL1A, BMP2, BMP6, BCL2, JUN, FOS
43	p38 Signaling36	7.5	IL1A, IL1B, IL2RA, BMP6, CSF3, CX3CL1
44	Rho Family GTPases36	7.4	IL8, MAPK1, CCL2, IGF1, GH1, GHRH
45	Cytokine-cytokine receptor interaction20	7.4	EPO, CSF3, CX3CL1, PRL, ACVR1B, ACVR2A
46	TGF-Beta Pathway36	7.4	BDNF, GHRH, GH1, IGF1, CCL2, MAPK1
47	MAPK Family Pathway36	7.3	CREB1, IL1B, IL2RA, IL8, MAPK1, CCL2
48	JAK-STAT Pathway36	7.3	IL1A, MAPK1, IL8, IL10, JUN, FOS
49	Antioxidant Action of Vitamin-C36	7.1	IL10, IL18, IL1A, FOS, CSF3, JUN
50	MIF Regulation of Innate Immune Cells36	7.0	BCL2, CCL2, IL18, IL1A, IL1B, IL6

Compounds related to traumatic brain injury according to GeneDecks:

(show top 50)    (show all 548)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	VCAN, CKB, XIAP, S100B, MME, MIP
2	ionomycin32	10.6	KCNN4, KCNN1, FOS, CAPN1, PTK2B, SNCA
3	polyethylene glycol32	10.0	SERPINC1, BMP2, APOE, MBP, GHRH, HMOX1
4	isoproterenol32 9 9	11.9	IL1A, APP, MAPK1, GH1, PTK2B, CREB1
5	sodium nitroprusside32	9.9	BMP6, BDKRB2, S100B, MME, APP, FASLG
6	sp 60012532 42	10.8	CASP3, TP53, CYCS
7	aprotinin32 9 9	11.8	SERPINC1, BDKRB2, MMP9, IL1A, IGF1, F2
8	estradiol32 9 18 9	12.8	BDNF, XIAP, GRN, IL18, FASN, FASLG
9	atp32	9.8	PARP1, BDKRB2, BDNF, KCNN4, KCNN1, CKB
10	pravastatin32 34 9 18 9	13.7	BMP2, FDFT1, IL18, IL6, APOE, CCL2
11	ascorbic acid32 18	10.6	BMP2, BDNF, BACE1, S100B, MME, IL1A
12	ketamine32 9 9	11.3	BDNF, IL10, HMOX1, DRD2, PTK2B, NOS1
13	calcium32 9 18 9	12.3	RETN, BMP2, BDKRB2, BDNF, KCNN4, KCNN1
14	calcitriol32 42 9 18 9	13.0	BMP2, BMP6, XIAP, S100A8, S100A9, JUN
15	tacrolimus32 34 9 9	11.8	BMP2, BMP6, CDKN3, MIP, INS, IL10
16	corticosterone32 18	9.7	BDNF, FOS, IL1A, IL1B, IL1RN, APP
17	atorvastatin32 34 9 18 9	12.7	RETN, VEGFA, BMP2, BMP6, MMP9, FDFT1
18	nmda32 42	9.7	BDNF, LEP, XIAP, CDKN3, FOS, IL1A
19	histamine32 18	9.7	BMP6, BDKRB2, BDNF, KCNN4, S100A8, MME
20	dopamine32 9 18 9	11.5	BMP2, BMP6, BDNF, CHRM1, UCHL1, MTHFR
21	adenylate32	8.5	SERPINC1, BDKRB2, BDNF, CHRM1, S100B, CDKN3
22	rottlerin32 42	9.5	PARP1, XIAP, JUN, IL8, MAPK1, CASP7
23	5-hydroxytryptamine32	8.3	BMP6, CHRM1, CDKN3, MME, IL1A, APP
24	forskolin32 42 9 9	11.2	RETN, BMP2, BMP6, BDKRB2, BDNF, CKB
25	octreotide32 42 9 9	11.2	VEGFA, MME, INS, ENO2, IGF1, GH1
26	acth32	8.1	BDNF, LEP, MME, INS, IL1A, IL1B
27	5fluorouracil32	8.0	VEGFA, KDR, BCL2, MTHFR, XIAP, FEN1
28	doxorubicin32 34 9 9	10.9	VEGFA, BMP6, PARP1, BDNF, KDR, BCL2
29	quercetin32 42 9 18 9	11.8	PARP1, BCL2, JUN, MME, IL10, IL1B
30	nitric oxide32 9 18 9	10.8	RETN, BMP2, BMP6, BDKRB2, KDR, CHRM1
31	sb 20358032 42	8.7	VEGFA, BMP2, BMP6, PARP1, BCL2, MMP3
32	oxygen32 18	8.7	BMP2, PARP1, BDNF, BCL2, CKB, BACE1
33	cholesterol32 9 18 9	10.6	RETN, BMP2, BDNF, LEP, BACE1, MTHFR
34	lipid32	7.6	RETN, BMP2, BDKRB2, BDNF, LEP, CHRM1
35	simvastatin32 34 42 9 18 9	12.2	VEGFA, BMP2, BMP6, KDR, BACE1, MMP3
36	arginine32	7.2	SERPINC1, BMP2, BDKRB2, LEP, CHRM1, S100B
37	diphenyleneiodonium32	7.1	VEGFA, JUN, CDKN3, IL1B, IL8, MAPK1
38	15-deoxy-delta-12,14-prostaglandin j232	6.9	VEGFA, BMP6, JUN, FOS, IL10, IL1B
39	estrogen32	6.7	RETN, SERPINC1, BMP2, BDNF, KDR, CKB
40	cisplatin32 34 9 9	9.3	VEGFA, BMP6, PARP1, BDNF, KDR, BCL2
41	norepinephrine32 9 18 9	9.2	RETN, BMP6, BDNF, LEP, S100B, MMP9
42	cyclosporin a32 42	7.1	BMP2, LEP, MTHFR, S100B, JUN, CDKN3
43	wortmannin32 42	7.1	BMP2, BDNF, KDR, BCL2, LEP, S100B
44	troglitazone32 42 9 9	9.1	BMP6, BCL2, LEP, JUN, MMP3, MMP9
45	butyrate32	6.0	BMP6, BCL2, LEP, XIAP, JUN, CDKN3
46	lactate32	6.0	BMP2, BMP6, BDNF, KDR, CKB, MT-CO2
47	curcumin32	6.0	VEGFA, PARP1, BCL2, XIAP, JUN, MMP3
48	genistein32 9 18 9	8.2	VEGFA, BMP2, PARP1, BDKRB2, KDR, BCL2
49	retinoic acid32 42 18	6.4	BMP2, BMP6, PARP1, BDNF, KDR, BCL2
50	actinomycin d32	4.3	RETN, VEGFA, BMP2, PARP1, BDNF, BCL2

Cellular components related to traumatic brain injury according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	perikaryon	GO:043204	10.3	ENO2, CACNA1A, GHRH, AIF1, DRD2, NGB
2	perinuclear region of cytoplasm	GO:048471	10.0	PTGDS, SNCA, NOS1, ACHE, CX3CL1, PTK2B
3	synapse	GO:045202	9.9	SLC1A3, ACHE, NOS1, PLAT, SNCA, APP
4	integral to plasma membrane	GO:005887	9.8	ACVR1B, TACR1, SLC6A3, SLC1A1, SLC1A6, SLC6A4
5	neuronal cell body	GO:043025	9.8	ADORA1, SLC1A3, SLC6A3, UCHL1, S100B, APOE
6	plasma membrane	GO:005886	8.2	FASN, APP, APOE, APBB1, AQP7, FAS
7	cytosol	GO:005829	6.2	CKB, BCL2, ENO2, MAPK1, GORASP1, CASP7
8	extracellular space	GO:005615	5.2	IL10, IL18, IL18BP, IL1A, IL1B, IL1RN
9	extracellular region	GO:005576	5.1	EPO, RETN, IL18, IL18BP, IL1A, IL1B

Biological processes related to traumatic brain injury according to GeneDecks:

(show top 50)    (show all 51)

id	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter biosynthetic process	GO:042136	10.6	MAOA, NOS1, ACHE, TH, COMT, SLC6A3
2	positive regulation of renal sodium excretion	GO:035815	10.4	NPPB, TAC1, TACR1, DRD2, EDN1
3	sensory perception of pain	GO:019233	10.3	MME, P2RX4, HTR2A, NGF, EDN1, TACR1
4	positive regulation of multicellular organism growth	GO:040018	10.3	GHRH, SLC6A3, BCL2, CREB1, DRD2, GH1
5	axon guidance	GO:007411	10.2	SCN8A, APBB1, MAPK1, DPYSL2, TUBB3, SPTAN1
6	memory	GO:007613	10.2	SLC6A4, TH, S100B, IL1B, IL1RN, HTR2A
7	cellular response to hydrogen peroxide	GO:070301	10.2	F3, IL18, RHOB, IL6, IL18BP
8	elevation of cytosolic calcium ion concentration	GO:007204	10.1	BDKRB2, CYSLTR1, CACNA1A, TAC1, GHRH, IL1B
9	negative regulation of smooth muscle cell proliferation	GO:048662	10.1	COMT, NPPB, NOS3, HMOX1, AIF1
10	negative regulation of potassium ion transport	GO:043267	10.1	HTR2A, PTK2B, NOS3, NOS1
11	synaptic transmission	GO:007268	10.1	CREB1, TAC1, COMT, KCNN4, KCNN1, MBP
12	cellular response to organic substance	GO:071310	10.0	CASP3, IL1B, BCL2, SYP, CASP1
13	microglial cell activation	GO:001774	9.9	CASP1, AIF1, SNCA, JUN
14	cellular response to hypoxia	GO:071456	9.8	HIF1A, RPS27A, TP53, HMOX1, BBC3, BDKRB2
15	response to nicotine	GO:035094	9.8	EDN1, NGF, TACR1, HMOX1, SLC6A3, MMP9
16	regulation of blood pressure	GO:008217	9.7	LEP, SOD1, P2RX4, TAC1, ACE, NOS3
17	embryo implantation	GO:007566	9.7	MMP9, GRN, IL1B, SOD1, EPO
18	induction of apoptosis by intracellular signals	GO:008629	9.7	CASP7, XIAP, CASP3, TP53, CYCS, BBC3
19	response to glucocorticoid stimulus	GO:051384	9.5	NGF, PLAT, TPH2, CCL2, FAS, IL6
20	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	EDN1, AIF1, HMOX1, IL6, HIF1A, CX3CL1
21	positive regulation of angiogenesis	GO:045766	9.4	NOS3, F3, CX3CL1, VEGFA, KDR, MMP9
22	response to ethanol	GO:045471	9.4	MMP9, S100A9, SLC6A3, S100A8, BCL2, NOS3
23	cell-cell signaling	GO:007267	9.3	EDN1, FASLG, GHRH, IL10, IL1B, IL18
24	response to organic cyclic compound	GO:014070	9.3	JUN, IL1A, NOS3, NPPB, COMT, CASP1
25	response to estradiol stimulus	GO:032355	9.3	SLC6A4, NOS3, GH1, ENO2, IL1B, MMP9
26	female pregnancy	GO:007565	9.2	IL1RN, ADCYAP1, PRL, COMT, CRH, BCL2
27	response to heat	GO:009408	9.2	SOD1, NOS3, NOS1, TACR1, CCL2, MMP9
28	negative regulation of neuron apoptotic process	GO:043524	9.2	SOD1, BDNF, BCL2, JUN, NGF, HIF1A
29	platelet activation	GO:030168	9.1	SOD1, RHOB, ALB, F2, IGF1, MAPK1
30	positive regulation of endothelial cell proliferation	GO:001938	9.1	HIF1A, VEGFA, BMP2, BMP6, KDR, JUN
31	release of cytochrome c from mitochondria	GO:001836	9.0	CASP3, CASP7, JUN, BCL2, BBC3, TP53
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	IL6, INS, IGF1, GH1, VEGFA, TP53
33	neuron apoptotic process	GO:051402	9.0	TP53, BCL2, APP, CASP3, FAS
34	positive regulation of apoptotic process	GO:043065	8.9	RHOB, IL1B, MMP9, TP53, APBB1, FASLG
35	response to mechanical stimulus	GO:009612	8.8	BMP2, NGF, NOS3, F3, JUN, MMP9
36	response to lipopolysaccharide	GO:032496	8.8	SNCA, CASP1, S100A8, S100A9, JUN, MMP9
37	inflammatory response	GO:006954	8.7	IL1B, IL1A, IL18, IL10, FOS, S100A9
38	anti-apoptosis	GO:006916	8.6	EPO, SOD1, NGF, RPS27A, NOS3, APOE
39	signal transduction	GO:007165	8.6	CHRM1, TG, ANGPTL4, CCL2, DPYSL2, ADORA1
40	apoptotic process	GO:006915	8.5	BCL2, PTK2B, TM2D1, TP53, AIMP1, CASP1
41	small molecule metabolic process	GO:044281	8.5	VCAN, ENO2, HMOX1, HMGCR, CYCS, CYP46A1
42	aging	GO:007568	8.5	JUN, F3, SLC6A3, TSPO, NOS3, HMGCR
43	blood coagulation	GO:007596	8.4	F2, F3, IGF1, MAPK1, SERPINC1, VEGFA
44	angiogenesis	GO:001525	8.4	VEGFA, ANGPTL4, AIMP1, HMOX1, CCL2, RHOB
45	positive regulation of cell proliferation	GO:008284	8.2	CSF3, CHRM1, INS, FASLG, F2, HTR2A
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	POMC, BMP6, VEGFA, BMP2, HIF1A, ACVR1B
47	negative regulation of apoptotic process	GO:043066	7.9	CASP3, BCL2, ADORA1, AIF1, EPO, TP53
48	response to hypoxia	GO:001666	7.7	TH, VEGFA, BMP2, BCL2, LEP, MMP9
49	negative regulation of cell proliferation	GO:008285	7.5	COL18A1, DRD2, TP53, NOS3, IGF1, IL8
50	response to drug	GO:042493	7.5	MMP9, NOS3, COMT, NGF, EDN1, TSPO

Molecular functions related to traumatic brain injury according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium:dicarboxylate symporter activity	GO:017153	10.8	SLC1A7, SLC1A1, SLC1A6, SLC1A2, SLC1A3
2	L-glutamate transmembrane transporter activity	GO:005313	10.7	SLC1A2, SLC1A6, SLC1A1, SLC1A3, SLC1A7
3	beta-amyloid binding	GO:001540	10.5	APOE, TM2D1, ACHE, CST3, APBB1
4	drug binding	GO:008144	9.9	ACE, PPARA, HTR2A, HTR1A, CHRM1, DRD2
5	receptor binding	GO:005102	9.6	CX3CL1, ANGPTL4, FASLG, APP, P2RX4, BMP2
6	cytokine activity	GO:005125	9.1	IL18, FASLG, IL6, CSF3, EDN1, IL1B
7	protein heterodimerization activity	GO:046982	9.0	BCL2, APOE, ENO2, TP53, SPTAN1, SPTA1
8	protease binding	GO:002020	8.9	BDKRB2, BCL2, SERPINC1, INS, MBP, F3
9	growth factor activity	GO:008083	8.6	BMP6, NGF, VEGFA, BMP2, GH1, F2
10	hormone activity	GO:005179	8.5	RETN, LEP, INS, GH1, CRH, EDN1
11	protein binding	GO:005515	3.3	UCHL1, APP, FASN, ANGPTL4, MAPK1, IGF1