MCID: TRM010
MIFTS: 54

Traumatic Brain Injury malady

Neuronal category

Summaries for Traumatic Brain Injury

Sources:
34MedlinePlus, 3CDC, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Traumatic brain injury (tbi) happens when a bump, blow, jolt, or other head injury causes damage to the brain. every year, millions of people in the u.s. suffer brain injuries. more than half are bad enough that people must go to the hospital. the worst injuries can lead to permanent brain damage or death. half of all tbis are from motor vehicle accidents. military personnel in combat zones are also at risk. symptoms of a tbi may not appear until days or weeks following the injury. a concussion is the mildest type. it can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. people with a moderate or severe tbi may have those, plus other symptoms: a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures inability to awaken from sleep slurred speech weakness or numbness in the arms and legs dilated eye pupils health care professionals use a neurological exam and imaging tests to assess tbi. serious traumatic brain injuries need emergency treatment. treatment and outcome depend on how severe the injury is. tbi can cause a wide range of changes affecting thinking, sensation, language, or emotions. tbi can be associated with post-traumatic stress disorder. people with severe injuries usually need rehabilitation. nih: national institutes of neurological disorders and stroke

MalaCards: Traumatic Brain Injury is related to brain edema and brain cancer. An important gene associated with Traumatic Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neuroscience and SLC-mediated transmembrane transport. The compounds glutamate and cysteine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are behavior/neurological and cellular.

CDC:3 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. Every year, at least 1.7 million TBIs occur either as an isolated injury or along with other injuries.1

NINDS:44 Traumatic brain injury (TBI), a form of

Wikipedia:64 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force... more...

Aliases & Classifications for Traumatic Brain Injury

Sources:
44NINDS, 34MedlinePlus, 31LifeMap Discovery™
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

traumatic brain injury 44 34 31


Related Diseases for Traumatic Brain Injury

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to traumatic brain injury

Clinical Features for Traumatic Brain Injury

Drugs & Therapeutics for Traumatic Brain Injury

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Traumatic Brain Injury

Drug clinical trials:

Search ClinicalTrials for Traumatic Brain Injury

Search NIH Clinical Center for Traumatic Brain Injury

Search CenterWatch for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem), PMIDs: 23205020, 20637752, 23020860, 21248119

Genetic Tests for Traumatic Brain Injury

Anatomical Context for Traumatic Brain Injury

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Traumatic Brain Injury:

33
Bone marrow, Brain, Cortex, Spinal cord, Heart, Smooth muscle, Small intestine, Kidney, Liver, Lung, Thyroid, Myeloid, Monocytes, T cells, B cells, Endothelial, Prefrontal cortex, Olfactory bulb, Hypothalamus, Medulla oblongata, Adrenal cortex, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Traumatic Brain Injury or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Traumatic Brain Injury

Sources:
51PubMed
See all sources

Articles related to Traumatic Brain Injury:

(show top 50)    (show all 1073)
idTitleAuthorsYear
1
Adult functioning of mothers with traumatic brain injury at high risk of child abuse: A pilot study. (24401827)
2014
2
Do prolonged primary transport times for traumatic brain injury patients result in deteriorating physiology? A cohort study. (24112033)
2014
3
Early neuropsychological tests as correlates of return to driving after traumatic brain injury. (24328798)
2014
4
Emerging pharmacological agents to improve survival from traumatic brain injury. (24205899)
2013
5
Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury. (24002317)
2013
6
Life satisfaction 6-15 years after a traumatic brain injury. (23995834)
2013
7
Early diagnosis and management of cerebral venous flow obstruction secondary to transsinus fracture after traumatic brain injury. (24285968)
2013
8
The neural basis of impaired self-awareness after traumatic brain injury. (24371217)
2013
9
Multiple traumatic brain injury and concussive symptoms among deployed military personnel. (24070144)
2013
10
Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective. (24046354)
2013
11
Pressure ulcer in patients with severe traumatic brain injury: significant factors and association with neurological outcome. (24112115)
2013
12
The impact and prospect of traumatic brain injury on olfactory function: a cross-sectional and prospective study. (24071856)
2013
13
The mini-mental state examination and the montreal cognitive assessment after traumatic brain injury: an early predictive study. (24102622)
2013
14
Beta Blockers for Acute Traumatic Brain Injury: A Systematic Review and Meta-analysis. (24062229)
2013
15
Early down regulation of the glial Kir4.1 and GLT-1 expression in pericontusional cortex of the old male mice subjected to traumatic brain injury. (24026668)
2013
16
Use of the CRASH study prognosis calculator in patients with severe traumatic brain injury. (24094362)
2013
17
Evidence for Impaired Plasticity after Traumatic Brain Injury in the Developing Brain. (24050267)
2013
18
Retrospective analysis of levetiracetam compared to phenytoin for seizure prophylaxis in adults with traumatic brain injury. (24421550)
2013
19
Incidence of sport-related traumatic brain injury and risk factors of severity: a population-based epidemiologic study. (24060276)
2013
20
The impact of traumatic brain injury on pituitary function. (24011887)
2013
21
The Effects of Shilajit on Brain Edema, Intracranial Pressure and Neurologic Outcomes following the Traumatic Brain Injury in Rat. (23997917)
2013
22
Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism. (23660372)
2013
23
Social communication mediates the relationship between emotion perception and externalizing behaviors in young adult survivors of pediatric traumatic brain injury (TBI). (24140241)
2013
24
Ghrelin decreases motor deficits after traumatic brain injury. (24176206)
2013
25
Mindfulness-Based Cognitive Therapy Reduces Symptoms of Depression in People With a Traumatic Brain Injury: Results From a Randomized Controlled Trial. (24052092)
2013
26
Description of behaviors in nonverbal critically ill patients with a traumatic brain injury when exposed to common procedures in the intensive care unit: a pilot study. (24315278)
2013
27
Progressive sensorineural hearing loss, ataxia and anosmia as manifestation of superficial siderosis in post traumatic brain injury. (23053836)
2013
28
A 10-year follow-up study of patients with severe traumatic brain injury and dysautonomia treated with intrathecal baclofen therapy. (22668125)
2012
29
Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain. (21643999)
2011
30
Juguloarterial endothelin-1 gradients after severe traumatic brain injury. (20652766)
2011
31
Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. (21702960)
2011
32
BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. (20504155)
2010
33
The up-regulation of voltage-gated sodium channel Nav1.6 expression following fluid percussion traumatic brain injury in rats. (20421839)
2010
34
Coagulopathy in severe traumatic brain injury: a prospective study. (19131806)
2009
35
Neuroleptic malignant syndrome in traumatic brain injury patients treated with haloperidol. (19276778)
2009
36
Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury. (19429018)
2009
37
The serotonin transporter polymorphisms and major depression following traumatic brain injury. (18465388)
2008
38
Pituitary imaging abnormalities in patients with and without hypopituitarism after traumatic brain injury. (17556860)
2007
39
Intrathecal baclofen therapy for spastic hypertonia in chronic traumatic brain injury. (17453762)
2007
40
Differential immunoresponses following experimental traumatic brain injury, bone fracture and "two-hit"-combined neurotrauma. (17687516)
2007
41
Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury. (17020486)
2006
42
High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma. (16522687)
2006
43
Activin a release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury. (16958581)
2006
44
Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors. (15593389)
2005
45
Circadian blood pressure and heart rate changes in patients in a persistent vegetative state after traumatic brain injury. (16330896)
2005
46
Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. (15379997)
2004
47
Nitric oxide in traumatic brain injury. (15193032)
2004
48
Occurrence of pituitary dysfunction following traumatic brain injury. (15253797)
2004
49
Two-year prospective evaluation of the relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (10739425)
2000
50
Altered phenytoin pharmacokinetics in children with severe, acute traumatic brain injury. (11185666)
2000

Genetic Variations for Traumatic Brain Injury

Expression for genes affiliated with Traumatic Brain Injury

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for genes affiliated with Traumatic Brain Injury

Sources:
4Cell Signaling Technology, 54Reactome, 30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Compounds for genes affiliated with Traumatic Brain Injury

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1glutamate4511.4GFAP, CX3CL1, MIP, APOE, S100B, SLC1A7
2cysteine4511.4S100B, UCHL1, APOE, MIP, NGB, CX3CL1
3sodium45 2412.3MIP, SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
4chloride4511.2MIP, SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
5aspartate4511.2S100B, APOE, GFAP, SLC1A2, SLC1A1, SLC1A6
6calcium45 50 11 2414.2S100B, AIF1, MIP, CYSLTR2, CX3CL1, GFAP
7lipid4511.2S100B, APOE, MIP, NGB, CYSLTR2, GFAP
8serine4511.2S100B, UCHL1, APOE, NEFH, CX3CL1, GFAP
9potassium45 11 2413.2S100B, MIP, GFAP, SLC1A1, ACE, ENO2
10nitric oxide45 11 2413.2S100B, MIP, NGB, CYSLTR2, SLC1A2, SLC1A3
11glutamine4511.2S100B, APOE, GFAP, SLC1A2, SLC1A1, SLC1A3
12nmda45 2912.2APOE, GFAP, SLC1A7, SLC1A2, SLC1A1, SLC1A3
13dopamine45 29 11 2414.2S100B, UCHL1, APOE, GFAP, SLC1A2, ENO2
14[3h]d-aspartic acid2911.1SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
15[3h]etb-tboa2911.1SLC1A2, SLC1A1, SLC1A6, SLC1A3, SLC1A7
16superoxide45 2412.1UCHL1, NEFH, NGB, GFAP, SLC1A2, SLC1A3
17l-trans-2,4-pdc6011.1SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
18[3h]l-aspartic acid2911.1SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
19way 2136136011.1SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
20gaba4511.1S100B, GFAP, SLC1A2, SLC1A1, SLC1A3, ENO2
21dihydrokainic acid6011.1SLC1A1, SLC1A6, SLC1A3, SLC1A2, SLC1A7
22dl-tboa60 2912.1SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
23glucose4511.1MIP, NGB, GFAP, SLC1A2, SLC1A1, SLC1A3
24tfb-tboa6011.1SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
25alanine4511.1S100B, APOE, GFAP, SLC1A2, SLC1A1, SLC1A3
26dbc-amp4511.1S100B, GFAP, SLC1A2, SLC1A3, ENO2
27l-glutamic acid29 11 2413.1SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
28kainate45 2912.1APOE, GFAP, SLC1A2, SLC1A1, SLC1A3
29adenylate4511.1S100B, CYSLTR2, GFAP, SLC1A2, SLC1A3, ENO2
30dihydrokainate45 2912.0SLC1A3, SLC1A1, SLC1A2
31oxygen45 2412.0S100B, MIP, NGB, CYSLTR2, GFAP, SLC1A2
32edss4511.0ENO2, APOE, S100B
33acetylcholine45 50 29 11 2415.0ENO2, ACE, GFAP, APOE, S100B
34s 1004511.0S100B, GFAP, ENO2
35paraffin4510.9S100B, APOE, NEFH, GFAP, ENO2
36bromodeoxyuridine4510.9S100B, AIF1, GFAP, ENO2
37threo-3-methylglutamate2910.9SLC1A2, SLC1A6
38threo-beta-hydroxyaspartate4510.9SLC1A1, SLC1A3
39vegf4510.9S100B, APOE, MIP, CYSLTR2, GFAP, ENO2
40l-trans-pyrrolidine-2,4-dicarboxylic acid4510.9SLC1A2, SLC1A3
41iron45 2411.9S100B, NGB, GFAP, SLC1A2, ENO2
42dl-threo-beta-benzyloxyaspartate4510.9SLC1A2, SLC1A3
43mannitol45 1111.8AQP4, S100B
44spec-t4510.8ENO2, GFAP, APOE
45arginine4510.8S100B, APOE, MIP, CYSLTR2, GFAP, SLC1A2
46acth4510.8S100B, CYSLTR2, GFAP, ENO2
47tyrosine4510.7S100B, UCHL1, NEFH, MIP, CYSLTR2, GFAP
48lactate4510.7S100B, MIP, GFAP, SLC1A2, ENO2
49creatinine4510.7ENO2, ACE, GFAP, APOE, S100B
50[3h](2s,4r)-4-methylglutamate2910.3SLC1A2, SLC1A3

GO Terms for genes affiliated with Traumatic Brain Injury

Sources:
16Gene Ontology
See all sources

Cellular components related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.7AQP4, UCHL1, APOE, MIP, CYSLTR2, CX3CL1
2neuronal cell bodyGO:04302510.7SLC1A3, APOE, UCHL1, S100B

Biological processes related to Traumatic Brain Injury according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:05508510.8MIP, SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
2D-aspartate importGO:07077910.8SLC1A3, SLC1A1, SLC1A2
3L-glutamate importGO:05193810.7SLC1A3, SLC1A1, SLC1A2
4ion transportGO:00681110.7SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
5regulation of neuronal synaptic plasticityGO:04816810.6APOE, S100B
6response to woundingGO:00961110.5SLC1A3, SLC1A2, GFAP
7L-glutamate transportGO:01581310.3SLC1A6, SLC1A7

Molecular functions related to Traumatic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715310.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
2L-glutamate transmembrane transporter activityGO:00531310.7SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3glutamate bindingGO:01659510.6SLC1A3, SLC1A1
4glutamate:sodium symporter activityGO:01550110.5SLC1A1, SLC1A2
5tau protein bindingGO:04815610.3APOE, S100B

Products for genes affiliated with Traumatic Brain Injury

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Traumatic Brain Injury

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet