MCID: TRM003
MIFTS: 54

Tremor

Categories: Neuronal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Tremor

Summaries for Tremor

NINDS : 50 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, torso, and legs. Generally, tremor is caused by a problem in the deep parts of the brain that control movements.  Some forms of tremor are inherited and run in families, while others have no known cause. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older adults. There are several types of tremor, one of the most common of which is essential tremor (sometimes called benign essential tremor). The hands are most often affected but the head, voice, tongue, legs, and trunk may also be involved. Head tremor may be seen as a "yes-yes" or "no-no" motion. Onset is most common after age 40, although symptoms can appear at any age. Parkinsonian tremor is caused by damage to structures within the brain that control movement. The tremor is classically seen as a "pill-rolling" action of the hands but may also affect the chin, face, lips, and legs. Dystonic tremor occurs in individuals of all ages who are affected by dystonia, a movement disorder which causes muscles to be over-active, resulting in abnormal postures or sustained, unwanted movements.

MalaCards based summary : Tremor is related to multiple system atrophy 1 and essential tremor. An important gene associated with Tremor is C19orf12 (Chromosome 19 Open Reading Frame 12), and among its related pathways/superpathways are Neuroscience and Parkinsons Disease Pathway. The drugs Dopamine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related phenotypes are behavior/neurological and cardiovascular system

MedlinePlus : 40 Tremors are unintentional trembling or shaking movements in one or more parts of your body. Most tremors occur in the hands. You can also have arm, head, face, vocal cord, trunk, and leg tremors. Tremors are most common in middle-aged and older people, but anyone can have them. The cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. They commonly occur in otherwise healthy people. They may also be caused by problems such as Parkinson's disease Dystonia Multiple sclerosis Stroke Traumatic brain injury Alcohol abuse and withdrawal Certain medicines Some forms are inherited and run in families. Others have no known cause. There is no cure for most tremors. Treatment to relieve them depends on their cause. In many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. Tremors are not life threatening. However, they can be embarrassing and make it hard to perform daily tasks. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving oscillations... more...

Related Diseases for Tremor

Diseases in the Tremor family:

Tremor, Hereditary Essential, 1 Tremor, Hereditary Essential, 2
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4
Tremor, Hereditary Essential, 5 Essential Tremor

Diseases related to Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 multiple system atrophy 1 31.5 LRRK2 MAPT PRKN SNCA
2 essential tremor 31.4 CHCHD2 DRD3 FMR1 FUS HTRA2 LRRK2
3 parkinson disease 2, autosomal recessive juvenile 30.5 HTRA2 LRRK2 PRKN SNCA
4 parkinson disease 15, autosomal recessive early-onset 30.4 C19orf12 LRRK2 PRKN SNCA
5 movement disease 30.0 DRD3 FMR1 LRRK2 MAPT PRKN SNCA
6 restless legs syndrome 29.8 DRD3 PRKN SNCA
7 parkinson disease, late-onset 29.7 CHCHD2 DRD3 GBA LRRK2 MAPT PRKN
8 neuronal intranuclear inclusion disease 29.5 MAPT SNCA
9 supranuclear palsy, progressive, 1 29.4 LRRK2 MAPT PRKN SNCA
10 neurodegeneration with brain iron accumulation 1 29.3 C19orf12 SNCA
11 dementia 29.2 FUS GBA MAPT PRKN SNCA
12 primary orthostatic tremor 12.4
13 tremor, hereditary essential, 1 12.3
14 fragile x-associated tremor/ataxia syndrome 12.3
15 fragile x tremor/ataxia syndrome 12.3
16 tremor, hereditary essential, 4 12.2
17 tremor, hereditary essential, 5 12.1
18 tremor, hereditary essential, 2 12.1
19 tremor, hereditary essential, and idiopathic normal pressure hydrocephalus 12.0
20 tremor, hereditary essential, 3 11.9
21 tremor, nystagmus, and duodenal ulcer 11.9
22 tremor of intention, ataxia, and lipofuscinosis 11.8
23 sensorineural hearing loss-early graying-essential tremor syndrome 11.8
24 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 11.7
25 epilepsy, familial adult myoclonic, 2 11.7
26 epilepsy, familial adult myoclonic, 5 11.5
27 mental retardation, x-linked, syndromic, cabezas type 11.4
28 epilepsy, familial adult myoclonic, 1 11.4
29 myoclonic cerebellar dyssynergia 11.4
30 psychogenic movement 11.4
31 mental retardation, autosomal recessive 48 11.3
32 hereditary geniospasm 11.3
33 epilepsy, familial adult myoclonic, 3 11.3
34 dystonia 11.3
35 hypertrophic olivary degeneration 11.2
36 multiple sclerosis 11.1
37 cerebellar degeneration 11.1
38 central pontine myelinolysis 11.1
39 focal dystonia 11.1
40 roussy-levy hereditary areflexic dystasia 11.1
41 spinocerebellar ataxia 6 11.1
42 neurodegeneration with brain iron accumulation 3 11.1
43 japanese encephalitis 11.1
44 dystonia 12 11.1
45 cervical dystonia 11.0
46 aceruloplasminemia 11.0
47 epilepsy, familial adult myoclonic, 4 10.9
48 48,xxyy syndrome 10.9
49 pelizaeus-merzbacher disease 10.9
50 basal ganglia calcification 10.9

Graphical network of the top 20 diseases related to Tremor:



Diseases related to Tremor

Symptoms & Phenotypes for Tremor

MGI Mouse Phenotypes related to Tremor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 CNTN2 DRD3 FMR1 GBA HTRA2 LRRK2
2 cardiovascular system MP:0005385 9.86 DRD3 GBA HTRA2 LRRK2 MAPT PRKN
3 cellular MP:0005384 9.76 FMR1 GBA HTRA2 LRRK2 MAPT PRKN
4 integument MP:0010771 9.5 FMR1 GBA HTRA2 LRRK2 MAPT PRKN
5 nervous system MP:0003631 9.32 SNCA TENM4 CNTN2 DRD3 FMR1 GBA

Drugs & Therapeutics for Tremor

Drugs for Tremor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 372)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Donepezil Approved Phase 4 120014-06-4 3152
3
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
4
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
9
Levodopa Approved Phase 4,Phase 2,Phase 3,Phase 1 59-92-7 6047
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1 104987-11-3 445643 439492
11
Morphine Approved, Investigational Phase 4 57-27-2 5288826
12
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
13
Memantine Approved, Investigational Phase 4 19982-08-2 4054
14
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 657311 5754
15
Topiramate Approved Phase 4,Phase 3 97240-79-4 5284627
16
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
17
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
18
Pramipexole Approved, Investigational Phase 4,Phase 3 104632-26-0 119570 59868
19
Methadone Approved Phase 4 76-99-3 4095
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Entacapone Approved, Investigational Phase 4 130929-57-6 5281081
22
Carbidopa Approved Phase 4,Phase 2,Phase 3,Phase 1 28860-95-9 38101 34359
23
Phentermine Approved, Illicit Phase 4 122-09-8 4771
24
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 93-14-1 3516
26
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
27
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
28
Liraglutide Approved Phase 4,Phase 2,Phase 1 204656-20-2 44147092
29
Iodine Approved, Investigational Phase 4 7553-56-2 807
30
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
31
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
32
Imidazole Experimental, Investigational Phase 4 288-32-4 795
33
Butyric Acid Experimental, Investigational Phase 4,Phase 2,Early Phase 1 107-92-6 264
34 Etiracetam Investigational Phase 4,Phase 1,Phase 2 33996-58-6
35 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
36 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
37 Respiratory System Agents Phase 4,Phase 2,Phase 1
38 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
39 Adjuvants, Anesthesia Phase 4,Phase 3,Phase 2
40 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
42 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2
43 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
44 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
45 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 2,Phase 1
46 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 1
47 Formoterol Fumarate Phase 4,Phase 2
48 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
49 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Narcotics Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 521)

# Name Status NCT ID Phase Drugs
1 A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control Unknown status NCT00385359 Phase 4 Albuterol
2 The Effect of Donepezil on Gait and Balance in Parkinson's Disease Unknown status NCT01521117 Phase 4 Donepezil
3 Validation of DaTscan for Detection of Parkinson Disease Related Disorders Unknown status NCT02138682 Phase 4 l-123 Ioflupane
4 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4 Botulinum Toxin
5 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
6 Rapid Onset Action of Salbutamol Versus Formoterol Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
7 The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients Unknown status NCT01704248 Phase 4
8 A Pilot Clinical Trial Of Memantine for Essential Tremor Completed NCT00439699 Phase 4 Memantine
9 Pregabalin (Lyrica) for the Treatment of Essential Tremor Completed NCT00584376 Phase 4 Pregabalin;Placebo
10 Propranolol and Botulinum Toxin for Essential Vocal Tremor Completed NCT02111369 Phase 4 Propranolol
11 Pregabalin in the Treatment of Essential Tremor Completed NCT00646451 Phase 4 pregabalin;placebo capsules
12 Treatment of Pendular Nystagmus in OPT Completed NCT02466191 Phase 4 Memantine;Gabapentin
13 The Effect of Levetiracetam (Keppra) on the Treatment of Tremor in Multiple Sclerosis Completed NCT00430599 Phase 4
14 RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR) Completed NCT00998660 Phase 4
15 Effects of a Nutritional Supplement Combination on Body Weight Management Completed NCT01725958 Phase 4
16 Namenda (Memantine) for Non-Motor Symptoms in Parkinson's Disease Completed NCT00646204 Phase 4 Memantine;placebo
17 Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease Completed NCT00219284 Phase 4 Carbidopa/levodopa/entacapone
18 A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms Completed NCT00382967 Phase 4
19 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
20 Treatment of Bipolar Mania in Older Adults Completed NCT00254488 Phase 4 Lithium (LI);Divalproex (DV)
21 Pramipexole Versus Placebo in Parkinson's Disease (PD) Patients With Depressive Symptoms Completed NCT00297778 Phase 4 Pramipexole
22 QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE Completed NCT03045133 Phase 4 Methadone;Morphine
23 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
24 Study to Evaluate the Impact of Using Wearable Devices in Addition to Standard Clinical Practice on Parkinson´s Subject Symptoms Management Completed NCT03103919 Phase 4 Rotigotine
25 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
26 Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators Completed NCT02256319 Phase 4 Dexmedetomidine;Propofol
27 The Effects of Formula Diet on Body Weight, Body Composition, and Biomarkers for Disease Compared to a Standard Diet Completed NCT00138645 Phase 4
28 Aerosolized Beta-Agonist Isomers in Asthma Completed NCT02170532 Phase 4 levalbuterol;saline;ipratroprium
29 Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia Completed NCT00208091 Phase 4 Botulinum toxin, type B
30 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
31 SALT Study (Switching to the Administration of Lithium Slow -Release Treatment) Recruiting NCT03210480 Phase 4 Lithium sulphate prolonged-release 660 mg;Lithium carbonate immediate-release 150 mg and 300 mg
32 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss Recruiting NCT02928471 Phase 4
33 Improving Beta Cell Function in Mexican American Women With Prediabetes Recruiting NCT02488057 Phase 4 Liraglutide
34 Lidocaine vs Ketorolac for Renal Colic Recruiting NCT03137498 Phase 4 Lidocaine;Ketorolac
35 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Active, not recruiting NCT03098368 Phase 4 Rotigotine;Placebo
36 Atlas Predicted DBS Settings in Essential Tremor Enrolling by invitation NCT02678429 Phase 4
37 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
38 A Cross Over Pilot Study of Abobotulinum Toxin A (Dysport) as a Treatment for Task-dependent Upper Limb Tremor Not yet recruiting NCT03136341 Phase 4 Abobotulinum toxin A
39 CNS Study of Patients Switching From Tacrolimus to Envarsus Not yet recruiting NCT03270462 Phase 4 Envarsus XR
40 Effects of Analgesics in Cesarean Section Elective Not yet recruiting NCT03386630 Phase 4 Hyperbaric bupivacaine+Sufentanil;Hyperbaric bupivacaine+Morphine
41 Thymoglobulin Induction Therapy With Minimal Immunosuppression and Evaluation of Allograft Status Terminated NCT00731874 Phase 4 Tacrolimus
42 Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity Tremor Unknown status NCT00724906 Phase 3 123 I - ALTROPANE®
43 Intravenous Dexmedetomidine for Treatment of Shivering During Cesarean Section Under Neuraxial Anesthesia Unknown status NCT02384343 Phase 3 Dexmedetomidine;Normal saline
44 A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol Unknown status NCT01127568 Phase 2, Phase 3 Propranolol is available in generic form as the Wyeth product under the trade name Inderal.
45 E10A for the Treatment of Squamous Cell Carcinoma of the Head and Neck Unknown status NCT02630264 Phase 3 Endostatins;Paclitaxel injection;Cisplatin injection
46 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status NCT00163553 Phase 3 Pethidine;Placebo
47 A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. Completed NCT00236496 Phase 3 topiramate
48 Novel Therapies for Essential Tremor Completed NCT00018564 Phase 3 treatments for essential tremor
49 Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) Completed NCT01438710 Phase 3 Prograf;LCP-Tacro
50 The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor Completed NCT01018485 Phase 3 Botulinum Toxin Type A

Search NIH Clinical Center for Tremor

Genetic Tests for Tremor

Genetic tests related to Tremor:

# Genetic test Affiliating Genes
1 Tremor 28

Anatomical Context for Tremor

MalaCards organs/tissues related to Tremor:

38
Brain, Eye, Testes, Tongue, Thyroid, Cerebellum, Subthalamic Nucleus

Publications for Tremor

Articles related to Tremor:

(show top 50) (show all 1511)
# Title Authors Year
1
Infantile Tremor Syndrome: Response to B12 Therapy. ( 29422355 )
2018
2
Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson's disease motor subtypes. ( 29450651 )
2018
3
Voice Tremor in Parkinson's Disease: An Acoustic Study. ( 29395332 )
2018
4
Familial Cortical Myoclonic Tremor and Epilepsy, an Enigmatic Disorder: From Phenotypes to Pathophysiology and Genetics. A Systematic Review. ( 29416935 )
2018
5
Connectivity derived thalamic segmentation in deep brain stimulation for tremor. ( 29387530 )
2018
6
An In-Laboratory Validity and Reliability Tested System for Quantifying Hand-Arm Tremor in Motions. ( 29432113 )
2018
7
Shaky and unsteady: Dynamic posturography in essential tremor. ( 29406890 )
2018
8
A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation. ( 29307012 )
2018
9
Fragile X syndrome and fragile X-associated tremor ataxia syndrome. ( 29325626 )
2018
10
Directional communication during movement execution interferes with tremor in Parkinson's disease. ( 29427344 )
2018
11
Dysgeusia in deep brain stimulation for essential tremor. ( 29402567 )
2018
12
A method for characterizing essential tremor from the shoulder to the wrist. ( 29428341 )
2018
13
Tremor: Sorting Through the Differential Diagnosis. ( 29431985 )
2018
14
Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor. ( 29326295 )
2018
15
Prelemniscal Lesion for Selective Improvement of Parkinson Disease Tremor. ( 29408817 )
2018
16
Detection of atypical porcine pestivirus in Brazil in the central nervous system of suckling piglets with congenital tremor. ( 29393592 )
2018
17
Essential tremor. ( 29325613 )
2018
18
Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor. ( 29339654 )
2018
19
Age- and CGG Repeat-Related Slowing of Manual Movement in Fragile X Carriers: A Prodrome of Fragile X-Associated Tremor Ataxia Syndrome? ( 29389022 )
2018
20
Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson's disease or essential tremor. ( 29350074 )
2018
21
Tongue Fasciculations and Electrocardiographic Tremors in Spinal Muscular Atrophy. ( 29429566 )
2018
22
Erdheim-Chester Disease and Palatal Tremor. ( 29145922 )
2018
23
A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor. ( 29385917 )
2018
24
Pretherapeutic Functional Imaging Allows Prediction of Head Tremor Arrest After Thalamotomy for Essential Tremor: The Role of Altered Interconnectivity Between Thalamolimbic and Supplementary Motor Circuits. ( 29410136 )
2018
25
The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study. ( 29360867 )
2018
26
Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease. ( 29385927 )
2018
27
Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor. ( 29423509 )
2018
28
Double target DBS for essential tremor: 8-contact lead for cZI and vim aligned in the same trajectory. ( 29438045 )
2018
29
Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor. ( 29372062 )
2018
30
Knowledge about Essential Tremor: A Study of Essential Tremor Families. ( 29434571 )
2018
31
Clinical response to Vim's thalamic stereotactic radiosurgery for essential tremor is associated with distinctive functional connectivity patterns. ( 29335882 )
2018
32
Thalamic Deep Brain Stimulation Salvages Failed Focused Ultrasound Thalamotomy for Essential Tremor: A Case Report. ( 29433124 )
2018
33
Association study of essential tremor genetic loci in Parkinson'sA disease. ( 29398123 )
2018
34
Effects on cognition and quality of life with unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. ( 29385928 )
2018
35
Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. ( 28444183 )
2017
36
Topiramate for essential tremor. ( 28409827 )
2017
37
Feasibility study: Effect of hand resistance exercise on handwriting in Parkinson's disease and essential tremor. ( 28389133 )
2017
38
Heterotopic Purkinje Cells: a Comparative Postmortem Study of Essential Tremor and Spinocerebellar Ataxias 1, 2, 3, and 6. ( 28791574 )
2017
39
Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures. ( 27887893 )
2017
40
Probabilistic mapping of deep brain stimulation effects in essential tremor. ( 27981031 )
2017
41
Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population. ( 28158909 )
2017
42
Vocal tremor: where are we at? ( 28937519 )
2017
43
Adaptation of feedforward movement control is abnormal in patients with cervical dystonia and tremor. ( 28943258 )
2017
44
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction. ( 28491446 )
2017
45
Fragile X-associated tremor/ataxia syndrome. ( 29094559 )
2017
46
A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation. ( 28068428 )
2017
47
Clinical Characteristics of Parkinson's Disease Developed from Essential Tremor. ( 28409750 )
2017
48
Lessons I have learned from my patients: everyday life with primary orthostatic tremor. ( 28101372 )
2017
49
Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor. ( 28062908 )
2017
50
Topography of essential tremor. ( 28442304 )
2017

Variations for Tremor

ClinVar genetic disease variations for Tremor:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 C19orf12 NM_001031726.3(C19orf12): c.205G> A (p.Gly69Arg) single nucleotide variant Pathogenic rs515726205 GRCh37 Chromosome 19, 30193873: 30193873
2 LOC101927919; NUS1; SLC35F1 NC_000006.12 deletion Pathogenic GRCh37 Chromosome 6, 117961791: 118280044
3 LOC101927919; NUS1 NC_000006.12 deletion Pathogenic GRCh37 Chromosome 6, 117971549: 118218720
4 covers 24 genes, none of which curated to show dosage sensitivity NC_000006.11 deletion Pathogenic GRCh37 Chromosome 6, 116681080: 119775014

Copy number variations for Tremor from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 247217 9 129375646 129461836 Deletion FAM129B Tremor
2 247222 9 129375646 129461836 Deletion STXBP1 Tremor

Expression for Tremor

Search GEO for disease gene expression data for Tremor.

Pathways for Tremor

Pathways related to Tremor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 CNTN2 FMR1 LRRK2 MAPT PRKN SNCA
2 11.18 HTRA2 LRRK2 PRKN SNCA
3 10.66 PRKN SNCA

GO Terms for Tremor

Cellular components related to Tremor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.97 C19orf12 CHCHD2 HTRA2 LRRK2 PRKN SNCA
2 cell projection GO:0042995 9.88 DRD3 FMR1 LRRK2 MAPT TENM4
3 synapse GO:0045202 9.81 CNTN2 FMR1 LRRK2 SNCA
4 dendrite GO:0030425 9.71 FMR1 FUS LRRK2 MAPT
5 neuronal cell body GO:0043025 9.65 CNTN2 FUS LRRK2 MAPT SNCA
6 mitochondrial membrane GO:0031966 9.63 C19orf12 HTRA2 LRRK2
7 neuron projection GO:0043005 9.55 CNTN2 FMR1 LRRK2 PRKN TENM4
8 perikaryon GO:0043204 9.54 FMR1 FUS LRRK2
9 postsynapse GO:0098794 9.5 FMR1 LRRK2 SNCA
10 inclusion body GO:0016234 9.43 LRRK2 SNCA
11 growth cone GO:0030426 9.26 FMR1 LRRK2 MAPT SNCA
12 axon GO:0030424 9.02 CNTN2 FMR1 LRRK2 MAPT SNCA

Biological processes related to Tremor according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.83 C19orf12 LRRK2 PRKN
2 neuron projection development GO:0031175 9.81 CNTN2 GBA MAPT
3 response to oxidative stress GO:0006979 9.81 C19orf12 LRRK2 PRKN
4 cellular response to oxidative stress GO:0034599 9.77 HTRA2 LRRK2 SNCA
5 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.74 GBA LRRK2 PRKN
6 negative regulation of protein phosphorylation GO:0001933 9.73 LRRK2 PRKN SNCA
7 learning GO:0007612 9.72 CNTN2 DRD3 PRKN
8 response to cocaine GO:0042220 9.68 DRD3 SNCA
9 positive regulation of neuron death GO:1901216 9.67 MAPT SNCA
10 adult walking behavior GO:0007628 9.67 CNTN2 HTRA2
11 regulation of multicellular organism growth GO:0040014 9.67 DRD3 HTRA2
12 regulation of autophagy GO:0010506 9.67 LRRK2 MAPT PRKN
13 regulation of canonical Wnt signaling pathway GO:0060828 9.66 LRRK2 PRKN
14 regulation of reactive oxygen species metabolic process GO:2000377 9.65 PRKN SNCA
15 behavioral response to cocaine GO:0048148 9.65 DRD3 SNCA
16 regulation of neuronal synaptic plasticity GO:0048168 9.65 CNTN2 SNCA
17 adult locomotory behavior GO:0008344 9.65 HTRA2 PRKN SNCA
18 regulation of neuron death GO:1901214 9.64 LRRK2 SNCA
19 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.63 LRRK2 PRKN
20 positive regulation of proteasomal protein catabolic process GO:1901800 9.62 FMR1 PRKN
21 cellular protein catabolic process GO:0044257 9.62 HTRA2 PRKN
22 microglial cell activation GO:0001774 9.61 MAPT SNCA
23 cellular response to dopamine GO:1903351 9.61 LRRK2 PRKN
24 supramolecular fiber organization GO:0097435 9.6 MAPT SNCA
25 regulation of mitochondrial fission GO:0090140 9.58 LRRK2 MAPT
26 intracellular distribution of mitochondria GO:0048312 9.58 LRRK2 MAPT
27 regulation of dopamine secretion GO:0014059 9.58 DRD3 PRKN SNCA
28 dopamine uptake involved in synaptic transmission GO:0051583 9.54 PRKN SNCA
29 synaptic transmission, dopaminergic GO:0001963 9.54 DRD3 PRKN SNCA
30 protein localization to mitochondrion GO:0070585 9.52 LRRK2 PRKN
31 cellular response to manganese ion GO:0071287 9.51 LRRK2 PRKN
32 regulation of neurotransmitter secretion GO:0046928 9.5 FMR1 PRKN SNCA
33 positive regulation of dopamine receptor signaling pathway GO:0060161 9.46 DRD3 LRRK2
34 regulation of synaptic vesicle transport GO:1902803 9.43 LRRK2 PRKN
35 dopamine metabolic process GO:0042417 9.43 DRD3 PRKN SNCA
36 mitochondrion organization GO:0007005 9.35 CHCHD2 GBA HTRA2 LRRK2 PRKN
37 regulation of locomotion GO:0040012 9.33 DRD3 LRRK2 SNCA
38 negative regulation of neuron death GO:1901215 9.02 GBA HTRA2 LRRK2 PRKN SNCA

Molecular functions related to Tremor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.46 FMR1 LRRK2 MAPT SNCA
2 Hsp70 protein binding GO:0030544 9.37 PRKN SNCA
3 dynein complex binding GO:0070840 9.32 FMR1 SNCA
4 phospholipase binding GO:0043274 9.26 PRKN SNCA
5 identical protein binding GO:0042802 9.23 CNTN2 FMR1 FUS HTRA2 LRRK2 MAPT
6 tubulin binding GO:0015631 9.13 LRRK2 MAPT PRKN

Sources for Tremor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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