MCID: TRM003
MIFTS: 56

Tremor malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Tremor

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MedlinePlus:33 Tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk, and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. the cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. they commonly occur in otherwise healthy people. they may also be caused by problems such as parkinson's disease dystonia multiple sclerosis stroke traumatic brain injury alcohol abuse and withdrawal certain medicines some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke

MalaCards based summary: Tremor is related to parkinson's disease and essential tremor. An important gene associated with Tremor is DRD3 (dopamine receptor D3), and among its related pathways are Alpha-synuclein signaling and Neuroscience. The compounds duloxetine and raclopride have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and thyroid, and related mouse phenotypes are integument and endocrine/exocrine gland.

NINDS:43 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, trunk, and legs. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Some forms of tremor are inherited and run in families, while others have no known cause. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older persons.

Wikipedia:65 A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to and from... more...

Aliases & Classifications for Tremor

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Related Diseases for Tremor

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Diseases in the Essential Tremor family:

Tremor Hereditary Essential, 2 tremor
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4

Diseases related to Tremor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.9SNCA, PARK2, SLC6A3, DRD3, LRRK2
2essential tremor30.8FMR1, DRD3, SLC6A3, SNCA, PARK2, HS1BP3
3spinocerebellar ataxia30.4SNCA, FMR1
4parkinson disease 130.4SNCA
5progressive supranuclear palsy30.4FUS, SLC6A3
6migraine30.4DRD3, SLC6A3
7machado-joseph disease30.3SLC6A3, SNCA
8dementia30.2SLC6A3, FMR1, SNCA, PARK2, LRRK2
9obsessive-compulsive disorder30.1DRD3, SLC6A3
10movement disease30.1LRRK2, SNCA
11multiple system atrophy30.0PARK2, SNCA, FMR1, SLC6A3, LRRK2
12alzheimer's disease29.9PARK2, SNCA, DRD3, SLC6A3, LRRK2
13mood disorder29.8SLC6A3, DRD3
14tauopathy29.8SNCA, PARK2, LRRK2
15ataxia10.9
16fragile x-associated tremor/ataxia syndrome10.9
17dystonia10.7
18primary orthostatic tremor10.6
19cervical dystonia10.4
20cervicitis10.4
21myoclonus10.4
22multiple sclerosis10.4
23personality disorder10.3SLC6A3, DRD3
24neuronitis10.3
25neuropathy10.3
26blindness10.3
27substance dependence10.3SLC6A3, DRD3
28pathological gambling10.3DRD3, SLC6A3
29drug dependence10.3DRD3, SLC6A3
30gilles de la tourette syndrome10.3DRD3, SLC6A3
31cocaine dependence10.3SLC6A3, DRD3
32cerebellar ataxia10.3
33drug addiction10.3SLC6A3, DRD3
34rem sleep behavior disorder10.3SLC6A3, SNCA
35alcohol abuse10.3DRD3, SLC6A3
36striatonigral degeneration10.3SLC6A3, SNCA
37spasmodic dysphonia10.2
38substance abuse10.2SLC6A3, DRD3
39aphasia10.2FUS, C9orf72
40fragile x syndrome10.2
41mental retardation10.2
42cerebritis10.2
43cerebellar disease10.2
44focal dystonia10.2
45neuhauser daly magnelli syndrome10.2
46pontine hemorrhage10.2
47tremor hereditary essential, 210.2
48attention deficit hyperactivity disorder10.2FMR1, SLC6A3
49psychotic disorder10.1SLC6A3, DRD3
50memory impairment10.1SLC6A3, FMR1, SNCA

Graphical network of the top 20 diseases related to Tremor:



Diseases related to tremor

Symptoms for Tremor

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Drugs & Therapeutics for Tremor

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Drug clinical trials:

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Search NIH Clinical Center for Tremor

Genetic Tests for Tremor

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Anatomical Context for Tremor

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MalaCards organs/tissues related to Tremor:

32
Brain, Eye, Thyroid, Cortex, Testes, Thalamus, Cerebellum, Subthalamic nucleus, Tongue, Globus pallidus, Liver, Pituitary, Bone marrow, Bone, Retina, Spinal cord, Heart, Kidney, Adrenal gland, Parietal lobe, Hypothalamus, Caudate nucleus, Pineal

Animal Models for Tremor or affiliated genes

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MGI Mouse Phenotypes related to Tremor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6LRRK2, PARK2, SNCA, FMR1, SLC6A3
2MP:00053798.3GJD2, FMR1, SNCA, FUS, LRRK2, SLC6A3
3MP:00053848.2SLC6A3, LRRK2, FUS, PARK2, SNCA, FMR1
4MP:00053768.1DRD3, SLC6A3, SNCA, PARK2, LRRK2, GJD2
5MP:00053788.1FUS, SLC6A3, DRD3, FMR1, SNCA, PARK2
6MP:00030127.7SNCA, PARK2, C9orf72, FUS, LRRK2, GJD2
7MP:00053867.6SLC6A3, DRD3, LRRK2, FUS, PARK2, SNCA
8MP:00036317.6SNCA, FMR1, DRD3, GJD2, SLC6A3, PARK2

Publications for Tremor

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Articles related to Tremor:

(show top 50)    (show all 1154)
idTitleAuthorsYear
1
Non-steroidal anti-inflammatory drug use and essential tremor. (25376662)
2014
2
Re-thinking the biology of essential tremor: from models to morphology. (24262197)
2014
3
The "tremor diary": a useful tool in the management of patients with tremor. (25374769)
2014
4
Memantine Effects on Verbal Memory in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS): a Double-Blind Brain Potential Study. (24871547)
2014
5
Slow orthostatic tremor as the first manifestation of Grave's disease. (23468171)
2013
6
Functional Anatomy of Essential Tremor: Lessons from Neuroimaging. (23620075)
2013
7
Aging, hypertension and physiological tremor: the contribution of the cardioballistic impulse to tremorgenesis in older adults. (23385002)
2013
8
Upper-limb tremor suppression with a 7DOF exoskeleton power-assist robot. (24111275)
2013
9
Key issues in essential tremor genetics research: Where are we now and how can we move forward? (23450143)
2013
10
The microtubule associated protein tau H1 haplotype and risk of essential tremor. (24372973)
2013
11
Idiopathic head tremor in english bulldogs. (24375621)
2013
12
Reply: autosomal recessive epilepsy associated with contactin 2 mutation is different from familial cortical tremor, myoclonus and epilepsy. (23803302)
2013
13
Tremor. (24336002)
2013
14
Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI. (23869236)
2013
15
Ocular flutter in essential tremor: clinical course and response to primidone. (24061767)
2013
16
Temporal discrimination in patients with dystonia and tremor and patients with essential tremor. (23243072)
2013
17
Task-specific tremor in violinists: evidence of coactivation in the 3 to 8 Hz frequency range. (23853051)
2013
18
Is there a one-way street from essential tremor to Parkinson's disease? Possible biological ramifications. (24033795)
2013
19
Simultaneous thalamic and posterior subthalamic electrode insertion with single deep brain stimulation electrode for essential tremor. (22985104)
2013
20
Pure psychiatric presentation of Fragile X-associated tremor/ataxia syndrome. (23889896)
2013
21
RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome. (22459047)
2012
22
Smoking, dopamine transporter, and hand tremor. (22157025)
2012
23
Tremor and dystonia associated with thalamic cyst: a rare manifestation. (22649002)
2012
24
Fragile X-associated tremor ataxia syndrome in FMR1 gray zone allele carriers. (22161987)
2012
25
Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism. (22634324)
2012
26
Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. (22771283)
2012
27
Thalamic and subthalamic deep brain stimulation for essential tremor: where is the optimal target? (22426044)
2012
28
Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians. (21158743)
2011
29
Coprevalence of tremor with spasmodic dysphonia: a case-control study. (21792965)
2011
30
Factors associated with receptivity to deep brain stimulation surgery among essential tremor cases. (21561796)
2011
31
Marked reduction of tremor in essential tremor after putaminal infarct. (20581413)
2010
32
Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism. (20434388)
2010
33
Abnormal N400 word repetition effects in fragile X-associated tremor/ataxia syndrome. (20410144)
2010
34
Long-term results of thalamic deep brain stimulation for essential tremor. (19911883)
2010
35
Gait and balance in essential tremor: variable effects of bilateral thalamic stimulation. (19006189)
2009
36
Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. (18474448)
2009
37
Tremor. (19553813)
2009
38
An update on essential tremor. (19515278)
2009
39
Fertility in essential tremor. Data from population-based and clinical sources. (18784418)
2008
40
MRI and SPECT of midbrain and striatal degeneration in fragile X-associated tremor/ataxia syndrome. (18080849)
2008
41
Glutathione-S-transferase P1 polymorphism and risk for essential tremor. (18215156)
2008
42
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. (18543121)
2008
43
Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome. (18472227)
2008
44
Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. (17166801)
2007
45
Primary orthostatic tremor in a Scottish deerhound. (17028254)
2006
46
Gabapentin can improve postural stability and quality of life in primary orthostatic tremor. (15719416)
2005
47
Primary orthostatic tremor: analysis of three cases. (15559075)
2004
48
Somatosensory input to the ventrolateral thalamic region in the macaque monkey: potential substrate for parkinsonian tremor. (12483689)
2003
49
Head tremor in cervical dystonia. (10830347)
2000
50
Athetosis of Left Hand with Tremor of Right Hand. (19977013)
1913

Variations for Tremor

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Expression for genes affiliated with Tremor

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Expression patterns in normal tissues for genes affiliated with Tremor

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Pathways for genes affiliated with Tremor

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Compounds for genes affiliated with Tremor

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Compounds related to Tremor according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1duloxetine44 50 28 1113.2SLC6A3, DRD3
2raclopride44 2811.2DRD3, SLC6A3
3piperazine44 1111.2DRD3, SLC6A3
4sulpiride44 28 1112.2SLC6A3, DRD3
5pramipexole44 28 50 1113.2DRD3, SLC6A3
6quinpirole44 2811.2DRD3, SLC6A3
7heroin44 50 1112.2SLC6A3, DRD3
8bupropion50 44 24 1113.1SLC6A3, DRD3
91-benzyl-1,2,3,4-tetrahydroisoquinoline4410.1SNCA, SLC6A3
10paroxetine44 50 28 1113.1DRD3, SLC6A3
11dopac4410.1PARK2, DRD3
12quetiapine44 50 28 24 1114.0SLC6A3, DRD3
13bromocriptine44 28 1112.0SLC6A3, DRD3
14selegiline44 1111.0SLC6A3, SNCA
15risperidone44 50 28 61 24 1115.0SLC6A3, DRD3
16opiate449.8SLC6A3, DRD3
17apomorphine28 44 1111.8SNCA, DRD3, SLC6A3
18methamphetamine44 50 1111.8DRD3, SNCA, SLC6A3
19cocaine44 1110.8SNCA, DRD3, SLC6A3
20amphetamine44 50 1111.8SNCA, SLC6A3
21imipramine44 28 50 24 1113.7SLC6A3, DRD3
22catecholamine449.7PARK2, DRD3, SNCA
231 methyl 4 phenylpyridinium449.7PARK2, SNCA, SLC6A3
24norepinephrine44 24 1111.7DRD3, SNCA, SLC6A3
25rotenone449.6SLC6A3, PARK2, SNCA
26nmda44 2810.6DRD3, PARK2, SLC6A3
27gaba449.6GJD2, SLC6A3, FMR1
28olanzapine44 50 28 24 1113.5SLC6A3, DRD3
29glutamate449.4FMR1, DRD3, SNCA, SLC6A3
306-hydroxydopamine449.4SLC6A3, DRD3, SNCA, PARK2
31mptp449.4SLC6A3, DRD3, SNCA, PARK2
32gtp44 2810.4DRD3, LRRK2, PARK2
33cysteine449.1SNCA, DRD3, SLC6A3, PARK2
34levodopa44 1110.0DRD3, SNCA, PARK2, LRRK2, SLC6A3
35dopamine44 28 24 1111.5PARK2, SNCA, SLC6A3, GJD2, LRRK2, DRD3

GO Terms for genes affiliated with Tremor

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Cellular components related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.7SNCA, LRRK2
2inclusion bodyGO:0162349.6SNCA, LRRK2
3axonGO:0304249.0SLC6A3, SNCA, LRRK2

Biological processes related to Tremor according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dopamine receptor signaling pathwayGO:06016110.1DRD3, LRRK2
2regulation of dopamine secretionGO:01405910.0DRD3, SNCA
3regulation of locomotionGO:0400129.9LRRK2, SNCA
4prepulse inhibitionGO:0601349.9SLC6A3, DRD3
5dopamine biosynthetic processGO:0424169.9SLC6A3, SNCA
6behavioral response to cocaineGO:0481489.9SNCA, DRD3
7response to cocaineGO:0422209.8SLC6A3, DRD3
8neuron deathGO:0709979.8LRRK2, PARK2
9negative regulation of protein phosphorylationGO:0019339.5PARK2, SNCA
10autophagyGO:0069149.3C9orf72, LRRK2
11response to drugGO:0424939.1SLC6A3, DRD3, SNCA
12cell deathGO:0082198.8SLC6A3, PARK2, C9orf72, FUS

Molecular functions related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8DRD3, SLC6A3
2drug bindingGO:0081449.8DRD3, SLC6A3
3identical protein bindingGO:0428028.8LRRK2, FUS, PARK2, SNCA
4protein bindingGO:0055156.9SLC6A3, LRRK2, FUS, C9orf72, PARK2, SNCA

Products for genes affiliated with Tremor

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Sources for Tremor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet