MCID: TRM003
MIFTS: 54

Tremor malady

Categories: Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Tremor

Summaries for Tremor

NINDS : 51 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, torso, and legs. Generally, tremor is caused by a problem in the deep parts of the brain that control movements.  Some forms of tremor are inherited and run in families, while others have no known cause. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older adults. There are several types of tremor, one of the most common of which is essential tremor (sometimes called benign essential tremor). The hands are most often affected but the head, voice, tongue, legs, and trunk may also be involved. Head tremor may be seen as a "yes-yes" or "no-no" motion. Onset is most common after age 40, although symptoms can appear at any age. Parkinsonian tremor is caused by damage to structures within the brain that control movement. The tremor is classically seen as a "pill-rolling" action of the hands but may also affect the chin, face, lips, and legs. Dystonic tremor occurs in individuals of all ages who are affected by dystonia, a movement disorder which causes muscles to be over-active, resulting in abnormal postures or sustained, unwanted movements.

MalaCards based summary : Tremor is related to neurosarcoidosis and personality disorder. An important gene associated with Tremor is TENM4 (Teneurin Transmembrane Protein 4), and among its related pathways/superpathways are Neuroscience and Parkinsons Disease Pathway. The drugs Dopamine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, tongue and eye, and related phenotypes are behavior/neurological and cellular

MedlinePlus : 41 tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk, and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. the cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. they commonly occur in otherwise healthy people. they may also be caused by problems such as parkinson's disease dystonia multiple sclerosis stroke traumatic brain injury alcohol abuse and withdrawal certain medicines some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke

Wikipedia : 71 A tremor /ˈtrɛmər/ is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving... more...

Related Diseases for Tremor

Diseases in the Tremor family:

Tremor, Hereditary Essential, 2 Essential Tremor
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4
Hereditary Essential Tremor 5

Diseases related to Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
id Related Disease Score Top Affiliating Genes
1 neurosarcoidosis 29.3 MAPT SLC1A2 SNCA
2 personality disorder 28.7 DRD3 FMR1 MAPT SLC6A3 SNCA
3 essential tremor 12.6
4 primary orthostatic tremor 12.2
5 fragile x-associated tremor/ataxia syndrome 12.2
6 fragile x tremor/ataxia syndrome 12.1
7 tremor, hereditary essential, 4 12.1
8 hereditary essential tremor 5 12.0
9 tremor, hereditary essential, 2 11.8
10 tremor, nystagmus, and duodenal ulcer 11.8
11 tremor, hereditary essential, 3 11.7
12 mental retardation, x-linked, with short stature, small testes, muscle wasting, and tremor 11.7
13 sensorineural hearing loss-early graying-essential tremor syndrome 11.7
14 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 11.4
15 epilepsy, myoclonic, familial adult, 5 11.4
16 epilepsy, myoclonic, familial adult, 2 11.4
17 mental retardation, x-linked, syndromic 15 11.3
18 myoclonic cerebellar dyssynergia 11.3
19 mental retardation, autosomal recessive 48 11.2
20 hereditary geniospasm 11.2
21 dystonia 11.2
22 multiple system atrophy 11.1
23 hypertrophic olivary degeneration 11.1
24 focal dystonia 11.0
25 roussy-levy syndrome 11.0
26 japanese encephalitis 11.0
27 cervical dystonia 10.9
28 cerebellar degeneration 10.9
29 central pontine myelinolysis 10.8
30 basal ganglia calcification 10.8
31 psychogenic movement 10.8
32 48,xxyy syndrome 10.8
33 neurodegeneration with brain iron accumulation 10.8
34 encephalitis 10.8
35 machado-joseph disease 10.8
36 parkinson disease, late-onset 10.8
37 spinal and bulbar muscular atrophy of kennedy 10.7
38 pol iii-related leukodystrophies 10.7
39 neuhauser daly magnelli syndrome 10.7
40 neuroaxonal dystrophy renal tubular acidosis 10.7
41 benign adult familial myoclonic epilepsy 10.7
42 spastic paraplegia 9b, autosomal recessive 10.6
43 ramsay hunt syndrome i 10.6
44 parkinson disease 21 10.6
45 spinocerebellar ataxia 2 10.6
46 von economo's disease 10.6
47 blepharospasm, primary benign 10.6
48 ataxia, cerebellar, cayman type 10.6
49 wilson disease 10.6
50 spinocerebellar ataxia 6 10.6

Graphical network of the top 20 diseases related to Tremor:



Diseases related to Tremor

Symptoms & Phenotypes for Tremor

MGI Mouse Phenotypes related to Tremor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 FMR1 SLC1A2 SLC6A3 GBA SNCA HTRA2
2 cellular MP:0005384 9.97 FMR1 SLC1A2 SLC6A3 GBA SNCA HTRA2
3 cardiovascular system MP:0005385 9.91 TENM4 DRD3 MAPT GBA HTRA2 SNCA
4 growth/size/body region MP:0005378 9.91 MAPT DRD3 SLC1A2 FMR1 SLC6A3 GBA
5 integument MP:0010771 9.7 FMR1 SLC6A3 GBA SNCA HTRA2 LRRK2
6 nervous system MP:0003631 9.7 DRD3 FMR1 SLC1A2 SLC6A3 GBA SNCA
7 taste/olfaction MP:0005394 8.8 MAPT SLC6A3 SNCA

Drugs & Therapeutics for Tremor

Drugs for Tremor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 354)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Donepezil Approved Phase 4 120014-06-4 3152
3
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
4
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
9
Levodopa Approved Phase 4,Phase 2,Phase 3,Phase 1 59-92-7 6047
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1 104987-11-3 445643 439492
11
Morphine Approved, Investigational Phase 4 57-27-2 5288826
12
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
13
Memantine Approved, Investigational Phase 4 19982-08-2 4054
14
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
15
Topiramate Approved Phase 4,Phase 3 97240-79-4 5284627
16
Procaterol Approved Phase 4 72332-33-3 688561
17
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2 137-58-6 3676
18
Pramipexole Approved, Investigational Phase 4,Phase 3 104632-26-0 59868 119570
19
Methadone Approved Phase 4 76-99-3 4095
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Entacapone Approved, Investigational Phase 4 130929-57-6 5281081
22
Carbidopa Approved Phase 4,Phase 2,Phase 3,Phase 1 28860-95-9 34359 38101
23
Phentermine Approved, Illicit Phase 4 122-09-8 4771
24
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
25
Guaifenesin Approved, Vet_approved Phase 4,Phase 2,Phase 1 93-14-1 3516
26
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
27
Liraglutide Approved Phase 4,Phase 1 204656-20-2
28
Butyric Acid Experimental Phase 4,Phase 2,Early Phase 1 107-92-6 264
29 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
30 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Cholinesterase Inhibitors Phase 4,Phase 3,Phase 2
32 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Narcotics Phase 4,Phase 3
34 Formoterol Fumarate Phase 4,Phase 2
35 Nasal Decongestants Phase 4
36 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
37 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
38 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2
39 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
40 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 2,Phase 1
41 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 1
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
44 Albuterol Phase 4,Phase 2,Phase 1
45 Tetrahydrozoline Phase 4
46 Tocolytic Agents Phase 4,Phase 2
47 Nootropic Agents Phase 4,Phase 1,Phase 2
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
49 Analgesics, Opioid Phase 4,Phase 3
50 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 470)
id Name Status NCT ID Phase
1 A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control Unknown status NCT00385359 Phase 4
2 The Effect of Donepezil on Gait and Balance in Parkinson's Disease Unknown status NCT01521117 Phase 4
3 Validation of DaTscan for Detection of Parkinson Disease Related Disorders Unknown status NCT02138682 Phase 4
4 The Use of Botox in Advanced Parkinson's Patients Experiencing Pain Unknown status NCT02472210 Phase 4
5 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4
6 Rapid Onset Action of Salbutamol Versus Formoterol Unknown status NCT00900874 Phase 4
7 The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients Unknown status NCT01704248 Phase 4
8 A Pilot Clinical Trial Of Memantine for Essential Tremor Completed NCT00439699 Phase 4
9 Pregabalin (Lyrica) for the Treatment of Essential Tremor Completed NCT00584376 Phase 4
10 Pregabalin in the Treatment of Essential Tremor Completed NCT00646451 Phase 4
11 Propranolol and Botulinum Toxin for Essential Vocal Tremor Completed NCT02111369 Phase 4
12 Treatment of Pendular Nystagmus in OPT Completed NCT02466191 Phase 4
13 The Effect of Levetiracetam (Keppra) on the Treatment of Tremor in Multiple Sclerosis Completed NCT00430599 Phase 4
14 RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR) Completed NCT00998660 Phase 4
15 Effects of a Nutritional Supplement Combination on Body Weight Management Completed NCT01725958 Phase 4
16 Namenda (Memantine) for Non-Motor Symptoms in Parkinson's Disease Completed NCT00646204 Phase 4
17 Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease Completed NCT00219284 Phase 4
18 A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms Completed NCT00382967 Phase 4
19 Treatment of Bipolar Mania in Older Adults Completed NCT00254488 Phase 4
20 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4
21 Pramipexole Versus Placebo in Parkinson's Disease (PD) Patients With Depressive Symptoms Completed NCT00297778 Phase 4
22 QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE Completed NCT03045133 Phase 4
23 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
24 Dexmedetomidine vs Propofol on the Recordings of Deep Brain Activity Measured Through Implanted Stimulators Completed NCT02256319 Phase 4
25 The Effects of Formula Diet on Body Weight, Body Composition, and Biomarkers for Disease Compared to a Standard Diet Completed NCT00138645 Phase 4
26 Aerosolized Beta-Agonist Isomers in Asthma Completed NCT02170532 Phase 4
27 Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia Completed NCT00208091 Phase 4
28 Study to Evaluate the Impact of Using Wearable Devices in Addition to Standard Clinical Practice on Parkinson´s Subject Symptoms Management Recruiting NCT03103919 Phase 4
29 Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss Recruiting NCT02928471 Phase 4
30 Improving Beta Cell Function in Mexican American Women With Prediabetes Recruiting NCT02488057 Phase 4
31 Lidocaine vs Ketorolac for Renal Colic Recruiting NCT03137498 Phase 4
32 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Active, not recruiting NCT03098368 Phase 4
33 A Toolbox Approach to Obesity Treatment in Primary Care Active, not recruiting NCT01922934 Phase 4
34 Atlas Predicted DBS Settings in Essential Tremor Enrolling by invitation NCT02678429 Phase 4
35 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4
36 A Cross Over Pilot Study of Abobotulinum Toxin A (Dysport) as a Treatment for Task-dependent Upper Limb Tremor Not yet recruiting NCT03136341 Phase 4
37 Thymoglobulin Induction Therapy With Minimal Immunosuppression and Evaluation of Allograft Status Terminated NCT00731874 Phase 4
38 Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity Tremor Unknown status NCT00724906 Phase 3
39 Intravenous Dexmedetomidine for Treatment of Shivering During Cesarean Section Under Neuraxial Anesthesia Unknown status NCT02384343 Phase 3
40 A Novel Treatment For Chronic Posttraumatic Stress Disorder (PTSD) Using Post-Reactivation Propranolol Unknown status NCT01127568 Phase 2, Phase 3
41 Neuraxial Pethidine After Lumbar Surgery Trial Unknown status NCT00163553 Phase 3
42 A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. Completed NCT00236496 Phase 3
43 Novel Therapies for Essential Tremor Completed NCT00018564 Phase 3
44 Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) Completed NCT01438710 Phase 3
45 The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor Completed NCT01018485 Phase 3
46 Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients Completed NCT00468078 Phase 3
47 A Trial of Levodopa in Angelman Syndrome Completed NCT01281475 Phase 2, Phase 3
48 Atkins Plus KetoCal for Childhood Epilepsy Completed NCT00681239 Phase 3
49 A Randomized Trial Comparing Two Doses of Portion-Controlled Foods Within a Primary Care Weight Loss Program Completed NCT00907660 Phase 2, Phase 3
50 Effects of Nutritional Products on Blood Glucose in Subjects With Type 2 Diabetes Completed NCT00753181 Phase 3

Search NIH Clinical Center for Tremor

Genetic Tests for Tremor

Genetic tests related to Tremor:

id Genetic test Affiliating Genes
1 Tremor 29

Anatomical Context for Tremor

MalaCards organs/tissues related to Tremor:

39
Brain, Tongue, Eye, Thyroid, Cortex, Testes, Cerebellum

Publications for Tremor

Articles related to Tremor:

(show top 50) (show all 1415)
id Title Authors Year
1
Coronal Transcranial Sonography and M-Mode Tremor Frequency Determination in Parkinson's Disease and Essential Tremor. ( 28426143 )
2017
2
A data mining approach using cortical thickness for diagnosis and characterization of essential tremor. ( 28526878 )
2017
3
Early Head Tremor in Essential Tremor: A Case Series and Commentary. ( 28373926 )
2017
4
A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. ( 28412948 )
2017
5
A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation. ( 28068428 )
2017
6
Pathological ponto-cerebello-thalamo-cortical activations in primary orthostatic tremor during lying and stance. ( 28031220 )
2017
7
Efficacy of Fiber Tractography in the Stereotactic Surgery of the Thalamus for Patients with Essential Tremor. ( 28458383 )
2017
8
Clinical Characteristics of Parkinson's Disease Developed from Essential Tremor. ( 28409750 )
2017
9
Letter: Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report. ( 28379503 )
2017
10
Thalamic DBS with a constant-current device in essential tremor: AA controlled clinical trial. ( 28400200 )
2017
11
Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife. ( 28044461 )
2017
12
Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures. ( 27887893 )
2017
13
Probabilistic mapping of deep brain stimulation effects in essential tremor. ( 27981031 )
2017
14
Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease. ( 28297702 )
2017
15
Topography of essential tremor. ( 28442304 )
2017
16
Emerging strategies in the management of essential tremor. ( 28382111 )
2017
17
Awareness of cognitive impairment in individuals with essential tremor. ( 28477687 )
2017
18
Ghrelin improves dystonia and tremor in patients with Rett syndrome: A pilot study. ( 28477699 )
2017
19
Topiramate for essential tremor. ( 28409827 )
2017
20
Mutation analysis of CHCHD2 gene in Chinese Han familial essential tremor patients and familial Parkinson's disease patients. ( 27814991 )
2017
21
Support System to Improve Reading Activity in Parkinson's Disease and Essential Tremor Patients. ( 28467366 )
2017
22
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles. ( 28503363 )
2017
23
Feasibility study: Effect of hand resistance exercise on handwriting in Parkinson's disease and essential tremor. ( 28389133 )
2017
24
Non-invasive Brain Stimulation for Essential Tremor. ( 28373927 )
2017
25
Action Tremor Asymmetry Profile Does Not Aggregate in Families with Essential Tremor. ( 28469594 )
2017
26
Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor. ( 28062908 )
2017
27
Cognitive Dysfunction Is Associated with Greater Imbalance and Falls in Essential Tremor. ( 28469597 )
2017
28
Intraoperative acceleration measurements to quantify improvement in tremor during deep brain stimulation surgery. ( 27631560 )
2016
29
Obsessive compulsive personality disorder in Progressive Supranuclear Palsy, Multiple System Atrophy and Essential Tremor. ( 27364040 )
2016
30
Postural tremor and chronic inflammatory demyelinating polyneuropathy. ( 27421831 )
2016
31
Epilepsy is not a mandatory feature of STXBP1 associated ataxia-tremor-retardation syndrome. ( 27184330 )
2016
32
Cerebellar dysfunction in essential tremor. ( 27062434 )
2016
33
SLC1A2 rs3794087 are associated with susceptibility to Parkinson's disease, but not essential tremor, amyotrophic lateral sclerosis or multiple system atrophy in a Chinese population. ( 27206883 )
2016
34
Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia. ( 26843004 )
2016
35
Patients with essential tremor can have manual dexterity and attention deficits with no impairments in other cognitive functions. ( 26982989 )
2016
36
Identification of a novel mutation in PLA2G6 gene in a Chinese pedigree with familial cortical myoclonic tremor with epilepsy. ( 27513994 )
2016
37
Molecular Pathophysiology of Fragile X-Associated Tremor/Ataxia Syndrome and Perspectives for Drug Development. ( 27277287 )
2016
38
A family study of DRD3 rs6280, SLC1A2 rs3794087 and MAPT rs1052553 variants in essential tremor. ( 27456607 )
2016
39
Movement disorders: Novel genetic risk variants for essential tremor. ( 27811916 )
2016
40
Neuropathic tremor associated with anti-MAG IgM-monoclonal gammopathy and prostate adenocarcinoma: Which one is the culprit? ( 27036215 )
2016
41
Deep Brain Stimulation Salvages a Flourishing Dental Practice: A Dentist with Essential Tremor Recounts his Experience. ( 27909628 )
2016
42
Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study. ( 27624392 )
2016
43
Fragile X-associated tremor/ataxia syndrome: another phenotype of the fragile X gene. ( 27355274 )
2016
44
Clinical Pearls in Tremor and Other Hyperkinetic Movement Disorders. ( 27643901 )
2016
45
Teaching Video NeuroImages: Palatal tremor in adult-onset Alexander disease. ( 27298457 )
2016
46
Precise stimulation location optimizes speech outcomes in essential tremor. ( 27595548 )
2016
47
Nonlinear interactions in the thalamocortical loop in essential tremor: A model-based frequency domain analysis. ( 26987955 )
2016
48
Reply to A<Orthostatic tremor secondary to recreational use of solventsA>. ( 27126564 )
2016
49
Genome-wide association study in essential tremor identifies three new loci. ( 27797806 )
2016
50
A case of a 17-year-old male with neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy presenting with tremor and ataxia. ( 27580761 )
2016

Variations for Tremor

ClinVar genetic disease variations for Tremor:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 C19orf12 NM_001031726.3(C19orf12): c.424A> G (p.Lys142Glu) single nucleotide variant Pathogenic rs146170087 GRCh37 Chromosome 19, 30193654: 30193654
2 C19orf12 NM_001031726.3(C19orf12): c.205G> A (p.Gly69Arg) single nucleotide variant Pathogenic rs515726205 GRCh37 Chromosome 19, 30193873: 30193873
3 LOC101927919; NUS1; SLC35F1 NC_000006.12 deletion Pathogenic GRCh38 Chromosome 6, 117640628: 117958881
4 LOC101927919; NUS1 NC_000006.12 deletion Pathogenic GRCh37 Chromosome 6, 117971549: 118218720
5 covers 24 genes, none of which curated to show dosage sensitivity NC_000006.11 deletion Pathogenic GRCh37 Chromosome 6, 116681080: 119775014

Copy number variations for Tremor from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 247217 9 129375646 129461836 Deletion FAM129B Tremor
2 247222 9 129375646 129461836 Deletion STXBP1 Tremor

Expression for Tremor

Search GEO for disease gene expression data for Tremor.

Pathways for Tremor

Pathways related to Tremor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 CNTN2 FMR1 LRRK2 MAPT SLC1A2 SNCA
2 11.18 HTRA2 LRRK2 SLC6A3 SNCA
3 10.66 SLC6A3 SNCA

GO Terms for Tremor

Cellular components related to Tremor according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.85 DRD3 FMR1 LRRK2 MAPT TENM4
2 synapse GO:0045202 9.81 CNTN2 FMR1 LRRK2 SNCA
3 dendrite GO:0030425 9.71 FMR1 FUS LRRK2 MAPT
4 neuron projection GO:0043005 9.65 CNTN2 FMR1 LRRK2 SLC6A3 TENM4
5 perikaryon GO:0043204 9.54 FMR1 FUS LRRK2
6 postsynapse GO:0098794 9.5 FMR1 LRRK2 SNCA
7 cytoplasmic ribonucleoprotein granule GO:0036464 9.49 FMR1 MAPT
8 inclusion body GO:0016234 9.48 LRRK2 SNCA
9 growth cone GO:0030426 9.46 FMR1 LRRK2 MAPT SNCA
10 axolemma GO:0030673 9.43 MAPT SLC1A2
11 neuronal cell body GO:0043025 9.43 CNTN2 FUS LRRK2 MAPT SLC6A3 SNCA
12 axon GO:0030424 9.17 CNTN2 FMR1 LRRK2 MAPT SLC1A2 SLC6A3
13 membrane GO:0016020 10.28 CNTN2 DRD3 FMR1 GBA HTRA2 LRRK2
14 plasma membrane GO:0005886 10.18 CNTN2 DRD3 FMR1 LRRK2 MAPT SLC1A2

Biological processes related to Tremor according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.8 DRD3 SLC1A2 SLC6A3 SNCA
2 aging GO:0007568 9.79 HTRA2 SLC6A3 SNCA
3 neuron projection development GO:0031175 9.74 CNTN2 GBA MAPT
4 cellular response to oxidative stress GO:0034599 9.65 HTRA2 LRRK2 SNCA
5 mitochondrion organization GO:0007005 9.63 GBA HTRA2 LRRK2
6 adult walking behavior GO:0007628 9.62 CNTN2 HTRA2
7 regulation of multicellular organism growth GO:0040014 9.61 DRD3 HTRA2
8 regulation of dopamine secretion GO:0014059 9.61 DRD3 SNCA
9 behavioral response to cocaine GO:0048148 9.6 DRD3 SNCA
10 regulation of neuron death GO:1901214 9.59 LRRK2 SNCA
11 regulation of neuronal synaptic plasticity GO:0048168 9.58 CNTN2 SNCA
12 synaptic transmission, dopaminergic GO:0001963 9.58 DRD3 SNCA
13 regulation of neurotransmitter secretion GO:0046928 9.56 FMR1 SNCA
14 microglial cell activation GO:0001774 9.55 MAPT SNCA
15 dopamine metabolic process GO:0042417 9.54 DRD3 SNCA
16 prepulse inhibition GO:0060134 9.52 DRD3 SLC6A3
17 supramolecular fiber organization GO:0097435 9.51 MAPT SNCA
18 dopamine biosynthetic process GO:0042416 9.43 SLC6A3 SNCA
19 intracellular distribution of mitochondria GO:0048312 9.4 LRRK2 MAPT
20 regulation of mitochondrial fission GO:0090140 9.37 LRRK2 MAPT
21 response to cocaine GO:0042220 9.33 DRD3 SLC6A3 SNCA
22 dopamine uptake involved in synaptic transmission GO:0051583 9.32 SLC6A3 SNCA
23 positive regulation of dopamine receptor signaling pathway GO:0060161 9.26 DRD3 LRRK2
24 negative regulation of neuron death GO:1901215 9.26 GBA HTRA2 LRRK2 SNCA
25 regulation of locomotion GO:0040012 8.8 DRD3 LRRK2 SNCA

Molecular functions related to Tremor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 9.32 MAPT SLC6A3
2 dynein complex binding GO:0070840 9.26 FMR1 SNCA
3 microtubule binding GO:0008017 9.26 FMR1 LRRK2 MAPT SNCA
4 identical protein binding GO:0042802 9.17 CNTN2 FMR1 FUS HTRA2 LRRK2 MAPT
5 dopamine binding GO:0035240 9.16 DRD3 SLC6A3

Sources for Tremor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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