Summaries for Tremor

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23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards
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MedlinePlus: Tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. tremors commonly occur in otherwise healthy people. sometimes, however, nerve diseases such as parkinson's disease or dystonia, an overactive thyroid, or certain medicines can cause them. heavy drinking, because it kills certain nerve cells, can cause tremors, too. some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke23

MalaCards: Tremor is related to essential tremor and parkinson's disease. An important gene associated with Tremor is DRD3 (dopamine receptor D3), and among its related pathways are Neuronal System and Estradiol metabolism. The compounds serine and arginine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and thyroid, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

NINDS: Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, trunk, and legs. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Some forms of tremor are inherited and run in families, while others have no known cause. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older persons.31

Wikipedia: A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to-and-fro...44 more...

Aliases & Descriptions for Tremor

Sources:
7diseasecard, 17Genetics Home Reference, 31NINDS, 23MedlinePlus
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tremor 7 17 31 23

Related Diseases for Tremor

Sources:
13GeneCards, 14GeneDecks
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Diseases related to tremor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor35.3GCH1, BTBD9, VIM, LINGO2, LINGO4, LINGO1
2parkinson's disease32.9PARK7, UCHL1, MAPT, SNCA, GBA
3ataxia29.4SGCE, SETX, VIM, USP14, PARK7, SCP2
4multiple system atrophy27.7PARK7, PARK2, UCHL1, ATXN2, ATP13A2, FRAXA
5spinocerebellar ataxia type 327.5PARK2, ATXN2, HTR3A, CACNA1A, SNCA, SLC6A3
6myoclonus-dystonia27.2SGCE, GCH1, DRD2, DRD3
7sepiapterin reductase deficiency27.2GCH1, PARK2, TPH1, DRD2, PTS, SLC6A3
8hypogonadism26.9PARK2, ATXN2, APOA1, CUL4B, GFAP, POLG
9focal dystonia26.9SGCE, PARK2, DRD2
10leukodystrophy26.6MPZ, ASPA, ARSA, PLP1, GFAP, POLR3A
11pick's disease26.4PARK7, UCHL1, MPZ, MAPT, HNMT, PTS
12cerebellar ataxia26.4SETX, SCN8A, ATXN2, ATCAY, FMR1, FGF14
13movement disease25.8PINK1, SGCE, GCH1, PARK7, PARK2, PANK2
14mental retardation syndrome25.7PARK2, LAMP2, MPP2, FRAXA, FMR1, ASPA
15peripheral neuropathy25.5SETX, MTHFR, ATXN2, MPZ, ARSA, GSTP1
16mood disorder25.2CNR1, HTR2A, HTR2C, HTR3A, TPH1, DRD2
17spasticity24.9CNR1, GCH1, PANK2, MTHFR, MPZ, CDKN3
18encephalitis24.8CNR1, MAPT, CCK, PTS, PLP1, COMT
19myoclonus24.8SGCE, GCH1, PARK2, ATXN2, CDKN3, FCMTE2
20neurodegeneration24.0PINK1, CNR1, PARK7, PARK2, PANK2, UCHL1
21alcoholism24.0CNR1, ARSA, MAPT, CCK, HTR2A, HTR2C
22seizures23.2CNR1, VIM, PARK2, SCN8A, MTHFR, XPNPEP3
23dementia22.1PINK1, PARK7, PARK2, PARK4, PANK2, UCHL1
24multiple sclerosis21.8PINK1, CNR1, VIM, LINGO1, PARK7, PARK2
25melanoma21.8VIM, PARK7, SCN8A, ATRN, CDKN3, ASS1
26neuropathy21.1CNR1, SETX, VIM, PARK2, SCP2, SCN8A
27blindness20.8CNR1, MTHFR, CDKN3, ASPA, APOA1, APOB
28obesity19.6CNR1, PARK2, MUC16, UCHL1, MTHFR, MTTP
29parkinson disease 1013.8PINK1, PARK7, PARK2, SNCA, LRRK2
30gaucher's disease13.8PARK2, MTHFR, LAMP2, ARSA, SNCA, GBA
31migraine without aura13.8MTHFR, CACNA1A, SLC6A3, GABRE, GABRQ
32sphingolipidosis13.7ARSA, NPC1, GBA
33drug-induced hepatitis13.7CYP2C19, CYP2D6, CYP2C9, CP
34schizophrenia13.6MTHFR, HTR2A, DRD3, COMT
35dentatorubral-pallidoluysian atrophy13.6ATXN2, CACNA1A, TPH1, GFAP
36dystonia musculorum deformans13.6GCH1, ASS1, HS1BP3
37spinocerebellar ataxia type 1713.5ATXN2, FGF14, CACNA1A, SLC6A3
38striatonigral degeneration13.5DRD2, SNCA, SLC6A3
39dysautonomia13.5PARK2, FMR1, IFNA2, SNCAIP, SNCA, GBA
40gaze palsy13.5ATP13A2, MAPT, SNCA, GBA
41major affective disorder13.4HTR2A, HTR3A, TPH1, SLC6A3
42friedreich ataxia13.3SETX, PANK2, ATXN2, ATCAY, FMR1, GSTP1
43olivopontocerebellar atrophy13.3ATXN2, MAPT, SNCA, SLC6A3
44gilles de la tourette syndrome13.3SGCE, HTR3A, DRD2, COMT, SLC6A3
45cognitive disease13.3PARK2, MAPT, HTR3A, DRD3, SNCA, COMT
46parkinson disease type 313.3PARK7, PARK2, MAPT, SNCAIP, SNCA, LRRK2
47tooth disease13.3MPZ, FIG4, GSTP1, TNNT1, PLP1, POLG
48lewy body dementia13.3PARK7, PARK2, MAPT, CYP2D6, SNCAIP, SNCA
49chorea13.3SGCE, CCK, GFAP, PRRT2, CP
50charcot-marie-tooth disease13.2MPZ, FIG4, GSTP1, TNNT1, PLP1, POLG

Graphical network of the top 20 diseases related to tremor:



Graphical network of diseases related to tremor

Clinical Features for Tremor

Drugs & Therapeutics for Tremor

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Tremor

Anatomical Context for Tremor

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22MalaCards
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MalaCards organs/tissues related to tremor:

22
Brain, Kidney, Thyroid, T cells, B cells, Pons, Pituitary

Phenotypes for genes affiliated with Tremor

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25MGI
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Publications for genes affiliated with Tremor

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35PubMed
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Articles related to tremor:

(show top 50)    (show all 144)
idTitleAuthorsYearAffiliating Genes
1Lingo2 variants associated with essential tremor and Parkinson's disease. (21287203)Wu Y.W.... Tan E.K.2011LINGO2
2STXBP1-related encephalopathy presenting as infantile spasms and generalized tremor in three patients. (21762454)Mignot C.... HAcron D.2011STXBP1
3Mutations in the Parkinson's disease genes, Leucine R ich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated wi th essential tremor. (19527940)Clark L.N.... Louis E.D.2010GBA, LRRK2
4Replication of the LINGO1 gene association with essen tial tremor in a North American population. (20372186)Clark L.N.... Louis E.D.2010LINGO1
5LINGO1 and LINGO2 variants are associated with essent ial tremor and Parkinson disease. (20369371)VilariA+o-GA1ell C.... Farrer M.J.2010LINGO1, LINGO2
6Gamma-aminobutyric acid (GABA) receptor rho (GABRR) p olymorphisms and risk for essential tremor. (20820800)GarcA-a-MartA-n E.... JimAcnez-JimAcnez F.J.2010GABARAP, GABRR2, GABRR1
7LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. (19720553)VilariA+o-GA1ell C.... Farrer M.J.2010LINGO1
8Functional status of men with the fragile X premutati on, with and without the tremor/ataxia syndrome (FXTAS). (19404994)Brega A.G.... Grigsby J.2009FMR1
9Levetiracetam improves intention tremor in fragile x- associated tremor/ataxia syndrome. (19471185)Saponara R.... Domina E.2009FMR1
10Molecular pathogenesis of fragile X-associated tremor /ataxia syndrome. (19794313)Raske C.... Hagerman P.J.2009FMR1
11Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients. (18556235)Vitale C.... Mandich P.2009LRRK2
12Variant in the sequence of the LINGO1 gene confers risk of essential tremor. (19182806)Stefansson H.... Stefansson K.2009LINGO1
13Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems. (18686748)Hagerman R.J.... Hagerman P.J.2008FMR1
14Essential tremor and the common LRRK2 G2385R variant. (18316234)Tan E.K.... Zhao Y.2008LRRK2
15(123)I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor. (18250955)Djaldetti R.... Yaniv E.2008SLC6A3
16Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor. (18718804)Sharkey L.M.... Meisler M.H.2008SCN8A
17Fragile X associated tremor/ataxia syndrome (FXTAS) with dementia in a female harbouring FMR1 premutation. (18487560)Karmon Y.... Gadoth N.2008FMR1
18Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. (18067184)Doepp F.... Schreiber S.J.2008SLC6A3
19Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome. (18211155)Grigsby J.... Reynolds A.2008FMR1
20DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients. (18484990)Vitale C.... Mandich P.2008DRD3
21Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening. (18098275)Clarimon J.... Kulisevsky J.2008LRRK2
22Dopamine transporter immunoreactivity in peripheral blood lymphocytes discriminates Parkinson's disease from essential tremor. (17260170)Pellicano C.... Pontieri F.E.2007SLC6A3
23Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome. (17591512)Bourgeois J.A.... Hagerman R.J.2007FMR1
24Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. (17221845)Zhao Y.... Tan E.K.2007FGF14
25Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. (17698009)Jin P.... Warren S.T.2007PURA
26Progression of tremor and ataxia in male carriers of the FMR1 premutation. (17133502)Leehey M.A.... Hagerman P.J.2007FMR1
27A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations. (17353387)Deng H.... Jankovic J.2007PARK2, HS1BP3
28Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. (17572665)Chow C.Y.... Meisler M.H.2007LAMP2, MPP2, FIG4
29Testicular and pituitary inclusion formation in fragile X associated tremor/ataxia syndrome. (17382748)Greco C.M.... Hagerman R.J.2007FMR1
30Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation. (16450344)Liang T.W.... Kotzbauer P.T.2006PANK2
31Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor. (16773639)Martin F.C.... Handforth A.2006GJD2
32CYP2C19 polymorphism and risk for essential tremor. (16960452)Alonso-Navarro H.... Jimenez-Jimenez F.J.2006CYP2C19
33Tumours and tremors: how PTEN regulation underlies both. (16495927)Kim R.H.... Mak T.W.2006PTEN, CDKN3
34Rabbit paralytic tremor phenotype--a plp1 gene mutati on as a model of human Pelizaeus-Merzbacher disease. (15960310)Sypecka J.... DomaA8ska-Janik K.2005PLP1
35A 60-year-old man with intention tremor as an initia l symptom followed by cerebellar ataxia, peripheral neuropathy and dementia (16146216)Machida Y.... Mizuno Y.2005CP
36MDR1 gene polymorphism in allogeenic kidney transplant patients with tremor. (15886424)Kotrych K.... Drozdzik M.2005ABCB1
37Fragile X-associated tremor/ataxia syndrome. (15981162)Lisik M.2005FMR1
38The fragile X tremor ataxia syndrome in the differential diagnosis of multiple system atrophy: data from the EMSA Study Group. (15947063)Kamm C.... Gasser T.2005FMR1
39Neurodevelopmental (fragile X syndrome) and neurodegenerative (tremor/ataxia syndrome) disorders associated to the 'growth' of a gene (15849678)Castro-Volio I.... Cuenca-Berger P.2005FMR1
40Severe action tremor related to interferon-alpha 2b t herapy for malignant melanoma. (16199995)Nishihori T.... Blum R.H.2005IFNA2
41Extended study of A265G variant of HS1BP3 in essential tremor and Parkinson disease. (16116142)Deng H.... Jankovic J.2005HS1BP3
42Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene. (15465096)Yamashita S.... Uchino M.2004PANK2
43Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor/ataxia syndrome. (15060119)Tassone F.... Hagerman P.J.2004FMR1
44Penetrance of the fragile X-associated tremor/ataxia syndrome in a premutation carrier population. (14747503)Jacquemont S.... Hagerman P.J.2004FMR1
45Progressive ataxia and palatal tremor (PAPT): clinical and MRI assessment with review of palatal tremors. (15090471)Samuel M.... Lang A.E.2004GFAP
46The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT. (11487195)Antonini A.... Fazio F.2001SLC6A3
47Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X. (11445641)Hagerman R.J.... Hagerman P.J.2001FMR1
48Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. (10820213)Kitada K.... Serikawa T.2000ASPA
49Paralytic tremor (pt): a new allele of the proteolipid protein gene in rabbits. (7525875)Tosic M.... Matthieu J.M.1994PLP1
50Linkage analysis with chromosome 9 markers in hereditary essential tremor. (8341306)Conway D.... Harding A.E.1993ASS1

Expression for genes affiliated with Tremor

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Tremor

Pathways for genes affiliated with Tremor

Sources:
38Reactome, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB, 20KEGG, 36QIAGEN, 3Cell Signaling Technology
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Pathways related to tremor according to GeneDecks:

(show all 25)
idPathwayScoreTop Affiliating Genes
1Neuronal System3810.6GABRA4, GABRA1, GJD2, GABRR1, GABRR2, GABRR3
2Estradiol metabolism4110.6CYP2C9, CYP2C8, CYP2C19, COMT, CYP2D6
3Estradiol metabolism1010.6COMT, CYP2C9, CYP2C19, CYP2C8, CYP2D6
4Phenytoin Pathway, Pharmacokinetics3410.6CYP2D6, COMT, CYP2C19, CYP2C8, CYP2C9
5Imatinib Pathway, Pharmacokinetics/Pharmacodynamics3410.6CYP2C9, CYP2D6, CYP2C19
6Fluvastatin Pathway, Pharmacokinetics3410.5CYP2C9, CYP2D6, CYP2C8, CYP2C19
7Biological oxidations3810.5CYP2D6, CYP2C8, CYP2C19, CYP2C9, ADH1B
8Celecoxib Pathway, Pharmacokinetics3410.5ADH1B, CYP2D6, CYP2C9
9Drug metabolism - cytochrome P4502010.4ADH1B, CYP2C9, CYP2D6, CYP2C8, CYP2C19, GSTP1
10Parkinsons Disease Pathway3610.4PINK1, PARK7, UCHL1, SNCAIP, PARK2, SNCA
11Cyclophosphamide Pathway, Pharmacokinetics3410.4CYP2C8, CYP2C19, CYP2C9
12Parkinsons disease2010.3SLC6A3, LRRK2, SNCAIP, HTRA2, SNCA, PARK2
13Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics3410.2CYP2C9, CYP2D6, CYP2C8, ABCB1
14Warfarin Pathway, Pharmacokinetics3410.1CYP2C9, CYP2C19, ABCB1, CYP2C8
15Gefitinib Pathway, Pharmacokinetics3410.1CYP2D6, CYP2C19, CYP2C9, ABCB1
16Statin Pathway - Generalized, Pharmacokinetics3410.1CYP2C19, CYP2C8, CYP2D6, CYP2C9, ABCB1
17Fluoxetine Pathway, Pharmacokinetics3410.1CYP2C19, CYP2C9, SLC6A4, CYP2D6
18Citalopram Pathway, Pharmacokinetics349.6CYP2C19, SLC6A4, ABCB1, CYP2D6
19Clopidogrel Pathway, Pharmacokinetics349.6ABCB1, CYP2C19, CYP2C9
20Statin Pathway, Pharmacodynamics349.3ABCB1, APOA1, MTTP, APOB
21Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics349.2TPH1, HTR2A, SLC6A4
22Metabolic pathways209.2PANK2, POLG2, POLG, COMT, CYP2C9, CYP2C8
23Neuroactive ligand-receptor interaction208.9DRD2, GABRR2, GABRR1, DRD3, GABRA4, GABRA1
24Amine ligand-binding receptors388.9DRD3, HTR2C, HTR2A, DRD2
25Neuroscience3INFLRRK2, PARK7, PARK2, ATP13A2, FMR1, GSTP1

Compounds for genes affiliated with Tremor

Sources:
32Novoseek , 9DrugBank, 34PharmGKB, 18HMDB, 42Tocris Bioscience
See all sources

Compounds related to tremor according to GeneDecks:

(show top 50)    (show all 384)
idCompoundScoreTop Affiliating Genes
1serine32 INFA2M, SNCA, PTS, PTEN, DRD3, GFAP
2arginine32 INFSLC6A4, CP, ASS1, FMR1, IGKV2D-29,
3Temazepam9 9 11.7GABRR1, CYP2C19, CYP2C8, CYP2C9, GABRE, GABRQ
4triazolam32 9 9 12.7GABRA1, GABRE, CYP2C9, CYP2C8, CYP2C19, GABRQ
5clobazam34 32 9 9 13.7GABRR2, GABRA4, GABRA1, GABRR3, GABRQ, GABRR1
6bromazepam32 9 9 12.7GABRR3, GABRR2, GABRE, GABRQ, CYP2C19, GABRA1
7alprazolam32 9 9 12.7CYP2C19, GABRE, CYP2C9, GABRQ, GABRR3, GABRA1
8chlordiazepoxide32 9 9 12.6GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ
9nitrazepam32 9 9 12.2GABRR2, GABRR1, GABRE, ABCB1, GABRA4, GABRQ
10diazepam32 34 9 9 13.2GABRR2, GABRA1, GABRR3, GABRQ, CYP2C19, CYP2C8
11midazolam32 9 9 12.2CYP2C19, ABCB1, GABRE, GABRQ, GABRR3, GABRA1
12flurazepam32 9 9 12.2GABRR2, GABRE, ABCB1, GABRR3, GABRA1, GABRA4
13quazepam32 9 9 12.0GABRR2, GABRE, CYP2C9, GABRR1, GABRA1, GABRR3
14lorazepam32 34 9 9 13.0GABRE, GABRR3, GABRA1, GABRA4, GABRR2, GABRR1
15selegiline32 9 9 12.0COMT, CYP2C9, CYP2C19, CYP2C8, CYP2D6, SNCA
16bupropion32 34 9 18 9 13.4DRD3, SLC6A4, SLC6A3, CYP2C9, CYP2D6, CYP2C8
17methamphetamine32 9 9 11.2DRD2, DRD3, CYP2D6, TPH1, SLC6A4, SLC6A3
18perphenazine32 34 9 9 12.0HTR2A, HTR3A, CYP2C8, CYP2C19, DRD2, CYP2C9
19levodopa32 9 9 10.9GCH1, CNR1, PINK1, PARK7, PARK2, MTHFR
20tegaserod32 9 9 10.6SLC6A4, HTR3A, HTR2C, HTR2A, CCK, CYP2D6
21fluvoxamine32 34 9 9 11.5HTR3A, TPH1, CYP2C19, SLC6A3, CYP2D6, ABCB1
22venlafaxine32 34 9 18 9 12.5HTR2A, ABCB1, SLC6A4, SLC6A3, CYP2D6, CYP2C19
23paroxetine32 34 9 9 11.5CYP2D6, CYP2C8, CYP2C19, TPH1, HTR3A, HTR2A
24mirtazapine32 34 9 9 11.4CYP2D6, HTR2A, HTR2C, SLC6A4, CYP2C9, HTR3A
25amitriptyline32 34 42 9 9 12.4SLC6A3, ABCB1, CYP2D6, SLC6A4, CYP2C19, HTR2A
26imipramine32 34 9 18 9 12.4HTR2A, CYP2D6, DRD3, HTR3A, GSTP1, MPZ
27olanzapine32 34 9 18 9 12.4CYP2C9, SLC6A3, CYP2D6, CYP2C19, COMT, ABCB1
28quetiapine32 9 18 9 11.3DRD2, HTR2C, HTR2A, HTR3A, DRD3, CYP2C19
29citalopram32 34 9 18 9 12.3SLC6A4, TPH1, CYP2C19, SLC6A3, ABCB1, CYP2C8
30trimipramine32 34 9 9 11.2DRD2, HTR2A, SLC6A4, SLC6A3, ABCB1, CYP2C9
31cocaine32 9 9 10.2CNR1, VIM, SLC6A3, GFAP, COMT, PLP1
32clomipramine32 34 9 9 11.2CYP2C19, CYP2D6, ABCB1, SLC6A3, SLC6A4, HTR3A
33nefazodone34 32 9 9 11.1HTR3A, CYP2D6, HTR2A, HTR2C, ABCB1, SLC6A3
34maoa32 8.1SLC6A3, COMT, TPH1, HTR2C, HTR2A, SLC6A4
35gaba32 42 9.0GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABARAP
36haloperidol32 34 9 9 10.9HTR3A, HTR2A, SLC6A4, SLC6A3, ABCB1, CYP2C9
37doxepin32 34 9 9 10.8CYP2C9, CYP2D6, HTR2A, HTR2C, DRD2, CYP2C19
38clozapine32 34 9 9 10.8SLC6A4, SLC6A3, ABCB1, CYP2C9, CYP2C8, DRD3
39risperidone32 34 9 18 9 11.8HTR2C, HTR2A, SLC6A4, SLC6A3, ABCB1, COMT
40fluoxetine32 34 9 9 10.6CNR1, HTR2A, SLC6A4, SLC6A3, ABCB1, CYP2C9
41cholesterol32 9 18 9 10.4CP, SNCA, SCP2, A2M, ABCB1, GFAP
425-hydroxytryptamine32 7.2HTR3A, HTR2C, HTR2A, CNR1, CCK, CDKN3
43dopamine32 9 18 9 INFADH1B, CP, SLC6A4, SLC6A3, GFAP, COMT
44glutamate32 INFGFAP, EIF4G1, COMT, PLP1, SNCA, PTS
45cysteine32 INFGBA, CP, NPC1, MTTP, MTHFR, UCHL1
46alanine32 INFAPOA1, IFNA2, APOB, PTEN, SNCAIP, EIF4G1
47testosterone32 9 18 9 INFALAD, CCK, , GSTP1, FMR1, MTHFR
48acetylcholine32 9 18 9 INFHTR2C, CYP2D6, SNCA, DRD2, VIM, CACNA1A
49methionine32 INFPARK7, VIM, GCH1, PLP1, PINK1, PON1
50choline32 9 18 9 INFAPOA1, ADH1B, MTHFR, , TPH1, APOB

GO Terms for genes affiliated with Tremor

Sources:
12Gene Ontology
See all sources

Cellular components related to tremor according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:005886INFHTR2C, HTR3A, CACNA1A, GJD2, DRD2, HTR2A
2chloride channel complexGO:03470710.6GABRR2, GABRE, GABRQ, GABRR3, GABRA1, GABRA4
3postsynaptic membraneGO:04521110.2GABRE, GABRQ, GABRR3, GABRA1, GABRA4, GABRR1
4cell junctionGO:03005410.0SYT12, GABRQ, HTR3A, GABRR2, GABRR1, GABRA4
5cytoplasmGO:0057376.1ATRN, SCP2, HTR2A, ATXN2, GCH1, SETX
6axonGO:030424INFHTR3A, VIM, PARK7, UCHL1, , CCK
7cytosolGO:005829INFPARK2, VPS35, GFAP, PINK1, GCH1, EIF4G1
8integral to plasma membraneGO:005887INFDRD2, HTR3A, HTR2A, MPZ, MPP2, ATRN

Biological processes related to tremor according to GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.8LRRK2, SNCA, DRD3
2monoterpenoid metabolic processGO:01609810.6CYP2D6, CYP2C19, CYP2C9
3dopamine biosynthetic processGO:04241610.5GCH1, SNCA, SLC6A3
4gamma-aminobutyric acid signaling pathwayGO:00721410.5GABRA1, GABRR2, CACNA1A, GABRE, GABRR3, GABRA4
5xenobiotic metabolic processGO:00680510.5GSTP1, ADH1B, COMT, CYP2C9, CYP2D6, CYP2C8
6ion transmembrane transportGO:03422010.5HTR3A, GABRR3, GABRA1, GABRA4, GABRR1, GABRR2
7drug metabolic processGO:01714410.5CYP2C8, CYP2D6, CYP2C9, CYP2C19
8exogenous drug catabolic processGO:04273810.4CYP2C19, CYP2C8, CYP2C9
9oxidative demethylationGO:07098910.3CYP2C8, CYP2D6, CYP2C9
10central nervous system developmentGO:0074179.9PTS, PTEN, GSTP1, FMR1, GABRA4, PARK2
11response to cocaineGO:0422209.9DRD3, DRD2, HNMT, HTR3A, CNR1, SLC6A3
12dopamine metabolic processGO:0424179.8DRD3, SNCAIP, DRD2
13prepulse inhibitionGO:0601349.8DRD2, DRD3, PTEN, SLC6A3
14negative regulation of blood pressureGO:0457769.8GCH1, DRD3, DRD2, CNR1
15regulation of dopamine secretionGO:0140599.4HTR2A, DRD2, DRD3, SNCA
16serotonin receptor signaling pathwayGO:0072109.3HTR3A, HTR2A, HTR2C
17response to stressGO:0069508.8PINK1, CNR1, UCHL1, HTR2A, TPH1, HTRA2
18synaptic transmissionGO:0072688.8HTR2A, COMT, PLP1, GJD2, CACNA1A, HTR3A
19cell deathGO:0082198.1VPS35, FIG4, ATXN2, UCHL1, PANK2, PARK2
20small molecule metabolic processGO:0442817.9PANK2, ASS1, ABCB1, CYP2D6, ARSA, GCH1
21response to drugGO:0424937.7NPC1, DRD2, HTR2C, HTR2A, ASS1, PARK7
22transmembrane transportGO:055085INFGABRA4, GABRR2, APOA1, HTR3A, ABCB1, SLC6A3
23transportGO:006810INFGABRR2, GABRA4, GABRA1, , SLC6A3, LAPTM4A
24adult walking behaviorGO:007628INFCACNA1A, UCHL1, , DRD2, NPC1, HTRA2

Molecular functions related to tremor according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1GABA-A receptor activityGO:00489010.5GABRR2, GABRR1, GABRE, GABRA4, GABRA1, GABRR3
2chloride channel activityGO:00525410.4GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRE
3extracellular ligand-gated ion channel activityGO:00523010.3GABRE, GABRR2, GABRR1, GABRA4, GABRA1, GABRR3
4monooxygenase activityGO:00449710.2CYP2C8, CYP2D6, CYP2C9, CYP2C19
5dopamine bindingGO:0352409.7DRD2, DRD3, SLC6A3
6serotonin bindingGO:0513789.2HTR2A, HTR2C, HTR3A
7drug bindingGO:0081448.7HTR2A, HTR2C, DRD2, DRD3, CYP2D6, CNR1
8protein bindingGO:005515INFABCB1, A2M, LRRK2, RPGRIP1L, SNCA, SNCAIP

Sources for Tremor

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS