MCID: TRM003
MIFTS: 55

Tremor malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Tremor

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34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk, and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. the cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. they commonly occur in otherwise healthy people. they may also be caused by problems such as parkinson's disease dystonia multiple sclerosis stroke traumatic brain injury alcohol abuse and withdrawal certain medicines some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Tremor is related to essential tremor and parkinson's disease. An important gene associated with Tremor is DRD3 (dopamine receptor D3), and among its related pathways are Alpha-synuclein signaling and Neuroscience. The compounds duloxetine and raclopride have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and thyroid, and related mouse phenotypes are integument and endocrine/exocrine gland.

NINDS:44 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, trunk, and legs. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Some forms of tremor are inherited and run in families, while others have no known cause. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older persons.

Wikipedia:65 A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to and from... more...

Aliases & Classifications for Tremor

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44NINDS, 34MedlinePlus, 25ICD10
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Related Diseases for Tremor

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17GeneCards, 18GeneDecks
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Diseases in the Essential Tremor family:

Tremor Hereditary Essential, 2 tremor
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4

Diseases related to Tremor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor31.6SLC6A3, LRRK2, HS1BP3, PARK2, SNCA, FMR1
2parkinson's disease31.2LRRK2, PARK2, SNCA, DRD3, SLC6A3
3dementia30.5LRRK2, PARK2, SNCA, FMR1, SLC6A3
4multiple system atrophy30.3LRRK2, PARK2, SNCA, FMR1, SLC6A3
5alzheimer's disease30.1LRRK2, PARK2, SNCA, DRD3, SLC6A3
6migraine30.1SLC6A3, DRD3
7spinocerebellar ataxia30.1SNCA, FMR1
8progressive supranuclear palsy30.0FUS, SLC6A3
9parkinson disease 129.9SNCA
10movement disease29.8LRRK2, SNCA
11spinocerebellar ataxia type 329.8SNCA, SLC6A3
12mood disorder29.7SLC6A3, DRD3
13tauopathy29.7LRRK2, PARK2, SNCA
14ataxia10.9
15fragile x-associated tremor/ataxia syndrome10.8
16dystonia10.7
17primary orthostatic tremor10.6
18cervical dystonia10.4
19cervicitis10.4
20myoclonus10.4
21multiple sclerosis10.4
22neuropathy10.3
23blindness10.3
24neuronitis10.3
25cerebellar ataxia10.3
26fragile x syndrome10.2
27spasmodic dysphonia10.2
28mental retardation10.2
29cerebritis10.2
30cerebellar disease10.2
31neuhauser daly magnelli syndrome10.2
32pontine hemorrhage10.2
33tremor hereditary essential, 210.2
34kennedy's disease10.1
35japanese encephalitis10.1
36focal dystonia10.1
37ophthalmoplegia10.1
38chorea10.1
39spasticity10.1
40personality disorder10.1SLC6A3, DRD3
41pathological gambling10.1DRD3, SLC6A3
42substance dependence10.1DRD3, SLC6A3
43drug dependence10.1DRD3, SLC6A3
44gilles de la tourette syndrome10.1DRD3, SLC6A3
45cocaine dependence10.1DRD3, SLC6A3
46drug addiction10.1SLC6A3, DRD3
47rem sleep behavior disorder10.1SLC6A3, SNCA
48alcohol abuse10.1DRD3, SLC6A3
49striatonigral degeneration10.1SLC6A3, SNCA
50obsessive-compulsive disorder10.1SLC6A3, DRD3

Graphical network of the top 20 diseases related to Tremor:



Diseases related to tremor

Symptoms for Tremor

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Drugs & Therapeutics for Tremor

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tremor

Search NIH Clinical Center for Tremor

Genetic Tests for Tremor

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Anatomical Context for Tremor

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33MalaCards
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MalaCards organs/tissues related to Tremor:

33
Brain, Eye, Thyroid, Cortex, Testes, Thalamus, Subthalamic nucleus, Cerebellum, Globus pallidus, Tongue, Pituitary, Liver, Pineal, Bone, Caudate nucleus, Retina, Hypothalamus, Spinal cord, Heart, Parietal lobe, Kidney, Adrenal gland, Bone marrow

Animal Models for Tremor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tremor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6LRRK2, PARK2, SNCA, FMR1, SLC6A3
2MP:00053798.3LRRK2, FUS, SNCA, FMR1, GJD2, SLC6A3
3MP:00053848.2LRRK2, FUS, PARK2, SNCA, FMR1, SLC6A3
4MP:00053768.1SLC6A3, GJD2, DRD3, SNCA, PARK2, LRRK2
5MP:00053788.1FUS, PARK2, SNCA, FMR1, DRD3, SLC6A3
6MP:00030127.7LRRK2, FUS, C9orf72, PARK2, SNCA, GJD2
7MP:00053867.6SLC6A3, LRRK2, FUS, PARK2, SNCA, FMR1
8MP:00036317.6LRRK2, FUS, PARK2, SNCA, FMR1, DRD3

Publications for Tremor

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52PubMed
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Articles related to Tremor:

(show top 50)    (show all 1102)
idTitleAuthorsYear
1
Re-thinking the biology of essential tremor: from models to morphology. (24262197)
2014
2
Slow orthostatic tremor as the first manifestation of Grave's disease. (23468171)
2013
3
Functional Anatomy of Essential Tremor: Lessons from Neuroimaging. (23620075)
2013
4
Aging, hypertension and physiological tremor: the contribution of the cardioballistic impulse to tremorgenesis in older adults. (23385002)
2013
5
Upper-limb tremor suppression with a 7DOF exoskeleton power-assist robot. (24111275)
2013
6
Key issues in essential tremor genetics research: Where are we now and how can we move forward? (23450143)
2013
7
The microtubule associated protein tau H1 haplotype and risk of essential tremor. (24372973)
2013
8
Idiopathic head tremor in english bulldogs. (24375621)
2013
9
Reply: autosomal recessive epilepsy associated with contactin 2 mutation is different from familial cortical tremor, myoclonus and epilepsy. (23803302)
2013
10
Tremor. (24336002)
2013
11
Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI. (23869236)
2013
12
Ocular flutter in essential tremor: clinical course and response to primidone. (24061767)
2013
13
Temporal discrimination in patients with dystonia and tremor and patients with essential tremor. (23243072)
2013
14
Task-specific tremor in violinists: evidence of coactivation in the 3 to 8 Hz frequency range. (23853051)
2013
15
Is there a one-way street from essential tremor to Parkinson's disease? Possible biological ramifications. (24033795)
2013
16
Simultaneous thalamic and posterior subthalamic electrode insertion with single deep brain stimulation electrode for essential tremor. (22985104)
2013
17
Pure psychiatric presentation of Fragile X-associated tremor/ataxia syndrome. (23889896)
2013
18
Multi-step prediction of physiological tremor for robotics applications. (24110876)
2013
19
RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome. (22459047)
2012
20
Smoking, dopamine transporter, and hand tremor. (22157025)
2012
21
Tremor and dystonia associated with thalamic cyst: a rare manifestation. (22649002)
2012
22
Task-specific tremor with use of scissors. (22517567)
2012
23
Fragile X-associated tremor ataxia syndrome in FMR1 gray zone allele carriers. (22161987)
2012
24
Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism. (22634324)
2012
25
Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. (22771283)
2012
26
Thalamic and subthalamic deep brain stimulation for essential tremor: where is the optimal target? (22426044)
2012
27
Analysis of Lingo1 variant in sporadic and familial essential tremor among Asians. (21158743)
2011
28
Coprevalence of tremor with spasmodic dysphonia: a case-control study. (21792965)
2011
29
Factors associated with receptivity to deep brain stimulation surgery among essential tremor cases. (21561796)
2011
30
Marked reduction of tremor in essential tremor after putaminal infarct. (20581413)
2010
31
Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism. (20434388)
2010
32
Abnormal N400 word repetition effects in fragile X-associated tremor/ataxia syndrome. (20410144)
2010
33
Long-term results of thalamic deep brain stimulation for essential tremor. (19911883)
2010
34
Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population. (20600614)
2010
35
Gait and balance in essential tremor: variable effects of bilateral thalamic stimulation. (19006189)
2009
36
Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. (18474448)
2009
37
Tremor. (19553813)
2009
38
An update on essential tremor. (19515278)
2009
39
Fertility in essential tremor. Data from population-based and clinical sources. (18784418)
2008
40
MRI and SPECT of midbrain and striatal degeneration in fragile X-associated tremor/ataxia syndrome. (18080849)
2008
41
Glutathione-S-transferase P1 polymorphism and risk for essential tremor. (18215156)
2008
42
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. (18543121)
2008
43
Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndrome. (18472227)
2008
44
Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. (17166801)
2007
45
Primary orthostatic tremor in a Scottish deerhound. (17028254)
2006
46
Gabapentin can improve postural stability and quality of life in primary orthostatic tremor. (15719416)
2005
47
Primary orthostatic tremor: analysis of three cases. (15559075)
2004
48
Somatosensory input to the ventrolateral thalamic region in the macaque monkey: potential substrate for parkinsonian tremor. (12483689)
2003
49
Head tremor in cervical dystonia. (10830347)
2000
50
Athetosis of Left Hand with Tremor of Right Hand. (19977013)
1913

Variations for Tremor

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Expression for genes affiliated with Tremor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tremor

Search GEO for disease gene expression data for Tremor.

Pathways for genes affiliated with Tremor

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50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome, 30KEGG
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Compounds for genes affiliated with Tremor

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45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Tremor according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1duloxetine45 51 29 1113.2DRD3, SLC6A3
2raclopride45 2911.2SLC6A3, DRD3
3piperazine45 1111.2SLC6A3, DRD3
4sulpiride45 29 1112.2DRD3, SLC6A3
5pramipexole45 29 51 1113.2SLC6A3, DRD3
6quinpirole45 2911.2SLC6A3, DRD3
7heroin45 51 1112.2SLC6A3, DRD3
8bupropion51 45 24 1113.1DRD3, SLC6A3
91-benzyl-1,2,3,4-tetrahydroisoquinoline4510.1SLC6A3, SNCA
10paroxetine45 51 29 1113.1DRD3, SLC6A3
11dopac4510.1DRD3, PARK2
12quetiapine45 51 29 24 1114.0SLC6A3, DRD3
13bromocriptine45 29 1112.0SLC6A3, DRD3
14selegiline45 1111.0SLC6A3, SNCA
15risperidone45 51 29 61 24 1115.0SLC6A3, DRD3
16opiate459.8SLC6A3, DRD3
17apomorphine29 45 1111.8SNCA, DRD3, SLC6A3
18methamphetamine45 51 1111.8SNCA, DRD3, SLC6A3
19cocaine45 1110.8SNCA, DRD3, SLC6A3
20amphetamine45 51 1111.8SNCA, SLC6A3
21imipramine45 29 51 24 1113.7DRD3, SLC6A3
22catecholamine459.7DRD3, SNCA, PARK2
231 methyl 4 phenylpyridinium459.7SLC6A3, SNCA, PARK2
24norepinephrine45 24 1111.7SNCA, DRD3, SLC6A3
25rotenone459.6SLC6A3, SNCA, PARK2
26nmda45 2910.6SLC6A3, DRD3, PARK2
27gaba459.6FMR1, GJD2, SLC6A3
28olanzapine45 51 29 24 1113.5SLC6A3, DRD3
29glutamate459.4SLC6A3, DRD3, FMR1, SNCA
306-hydroxydopamine459.4PARK2, SNCA, DRD3, SLC6A3
31mptp459.4PARK2, SNCA, DRD3, SLC6A3
32gtp45 2910.4DRD3, PARK2, LRRK2
33cysteine459.1PARK2, SNCA, DRD3, SLC6A3
34levodopa45 1110.0SLC6A3, DRD3, SNCA, PARK2, LRRK2
35dopamine45 29 24 1111.5LRRK2, PARK2, SNCA, DRD3, GJD2, SLC6A3

GO Terms for genes affiliated with Tremor

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16Gene Ontology
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Cellular components related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:0080219.7SNCA, LRRK2
2inclusion bodyGO:0162349.6SNCA, LRRK2
3axonGO:0304249.0SLC6A3, SNCA, LRRK2

Biological processes related to Tremor according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dopamine receptor signaling pathwayGO:06016110.1DRD3, LRRK2
2regulation of dopamine secretionGO:01405910.0DRD3, SNCA
3regulation of locomotionGO:0400129.9LRRK2, SNCA
4prepulse inhibitionGO:0601349.9SLC6A3, DRD3
5dopamine biosynthetic processGO:0424169.9SLC6A3, SNCA
6behavioral response to cocaineGO:0481489.9SNCA, DRD3
7response to cocaineGO:0422209.8SLC6A3, DRD3
8neuron deathGO:0709979.8LRRK2, PARK2
9negative regulation of protein phosphorylationGO:0019339.5PARK2, SNCA
10autophagyGO:0069149.3C9orf72, LRRK2
11response to drugGO:0424939.1SLC6A3, DRD3, SNCA
12cell deathGO:0082198.8SLC6A3, PARK2, C9orf72, FUS

Molecular functions related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8SLC6A3, DRD3
2drug bindingGO:0081449.8SLC6A3, DRD3
3identical protein bindingGO:0428028.8LRRK2, FUS, PARK2, SNCA
4protein bindingGO:0055156.9LRRK2, FUS, C9orf72, PARK2, SNCA, FMR1

Products for genes affiliated with Tremor

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Sources for Tremor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet