MCID: TRM003
MIFTS: 50

Tremor malady

Summaries for Tremor

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk, and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. the cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. they commonly occur in otherwise healthy people. they may also be caused by problems such as parkinson's disease dystonia multiple sclerosis stroke traumatic brain injury alcohol abuse and withdrawal certain medicines some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Tremor is related to essential tremor and parkinson's disease. An important gene associated with Tremor is DRD3 (dopamine receptor D3), and among its related pathways are Neuroscience and Parkinsons Disease Pathway. The compounds levodopa and dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are behavior/neurological and nervous system.

NINDS:44 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, trunk, and legs. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Some forms of tremor are inherited and run in families, while others have no known cause. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older persons.

Wikipedia:64 A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to and from... more...

Aliases & Classifications for Tremor

Sources:
44NINDS, 34MedlinePlus, 25ICD10
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Related Diseases for Tremor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the essential tremor family:

tremor

Diseases related to Tremor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor31.8PARK2, FMR1, DRD3, GABRQ, SNCA, LINGO1
2parkinson's disease31.0DRD3, SNCA, LRRK2, SLC6A3, PARK2
3fragile x-associated tremor/ataxia syndrome30.5FRAXA, FMR1
4progressive supranuclear palsy29.9FUS, SLC6A3
5tauopathy29.7PARK2, LRRK2, SNCA
6spinocerebellar ataxia type 329.7SLC6A3, SNCA
7ataxia10.9
8primary orthostatic tremor10.6
9n syndrome10.5
10cervical dystonia10.4
11brain disease10.4
12myoclonus10.4
13spasmodic dysphonia10.2
14focal dystonia10.2
15mental retardation10.2
16tremor hereditary essential, 210.1
17myoclonus epilepsy10.1
18pontine hemorrhage10.1
19restless legs syndrome10.1
20blepharospasm10.1
21japanese encephalitis10.1
22chorea10.1
23parkinson disease 110.1
24klinefelter's syndrome10.0
25canavan disease10.0
26central pontine myelinolysis10.0
27progressive multifocal leukoencephalopathy10.0
28alzheimer's disease10.0
29muscular atrophy10.0
30adult syndrome10.0
31astrocytoma10.0
32spinal muscular atrophy10.0
33spinocerebellar ataxia10.0
34x-linked spinal-bulbar muscle atrophy10.0
35spinal-bulbar muscular atrophy10.0
36myoclonus-dystonia10.0
37neuroferritinopathy10.0
38athetosis10.0
39tremors, nystagmus and duodenal ulcers10.0
40neuhauser daly magnelli syndrome10.0
41hemifacial spasm10.0
42epilepsy, familial adult myoclonic, 510.0
43myokymia10.0
44parkinson disease 1210.0
45sensorineural hearing loss - early graying - essential tremor10.0
46multiple system atrophy10.0FMR1, SNCA, LRRK2, SLC6A3, PARK2
47lewy body dementia10.0SNCA, LRRK2, SLC6A3
48dementia10.0FMR1, SNCA, LRRK2, SLC6A3, PARK2
49parkinson disease type 310.0PARK2, LRRK2, SNCA
50frontotemporal dementia10.0SNCA, LRRK2, PARK2, FUS

Graphical network of the top 20 diseases related to Tremor:



Diseases related to tremor

Clinical Features for Tremor

Drugs & Therapeutics for Tremor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tremor

Drug clinical trials:

Search ClinicalTrials for Tremor

Search NIH Clinical Center for Tremor

Search CenterWatch for Tremor

Genetic Tests for Tremor

Anatomical Context for Tremor

Sources:
33MalaCards
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MalaCards organs/tissues related to Tremor:

33
Bone marrow, Whole blood, Brain, Cortex, Cerebellum, Retina, Spinal cord, Heart, Kidney, Liver, Thyroid, Adrenal gland, T cells, B cells, Prefrontal cortex, Parietal lobe, Temporal lobe, Globus pallidus, Thalamus, Hypothalamus, Subthalamic nucleus, Caudate nucleus, Tongue, Adrenal cortex, Pineal, Pituitary

Animal Models for Tremor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Tremor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.6PARK2, SLC6A3, LRRK2, GJD2, SNCA, USP14
2MP:000363110.3FMR1, SLC6A3, LRRK2, GJD2, LINGO1, SNCA

Publications for Tremor

Sources:
51PubMed
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Articles related to Tremor:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
Reply: autosomal recessive epilepsy associated with contactin 2 mutation is different from familial cortical tremor, myoclonus and epilepsy. (23803302)
2013
2
Facial emotion recognition is inversely correlated with tremor severity in essential tremor. (24178244)
2013
3
VBM Reveals Brain Volume Differences between Parkinson's Disease and Essential Tremor Patients. (23785322)
2013
4
Tremor suppression by rhythmic transcranial current stimulation. (23416101)
2013
5
Corticomuscular coherence in asymptomatic first-degree relatives of patients with essential tremor. (23677898)
2013
6
Impact of discontinuing tremor suppressing medications following thalamic deep brain stimulation. (23062997)
2013
7
Asymmetric drug-induced tremor: rare feature of a common event. (23668878)
2013
8
Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it? (23582712)
2013
9
Sustained suppression of holmes tremor after cessation of thalamic stimulation. (23426802)
2013
10
Differences in cerebral perfusion according to phenotypes of essential tremor: brain perfusion SPECT study using SPM analysis. (24337969)
2013
11
RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome. (22459047)
2012
12
Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. (22771283)
2012
13
Increased number of Purkinje cell dendritic swellings in essential tremor. (22136494)
2012
14
Different patterns of cardiac sympathetic denervation in tremor-type compared to akinetic-rigid-type Parkinson's disease: molecular imaging with A^A^A^I-MIBG. (23023866)
2012
15
Long-term effects of deep brain stimulation for essential tremor with subjective and objective quantification via mailed-in questionnaires. (23018417)
2012
16
Non-invasive characterization of motor unit behaviour in pathological tremor. (22962251)
2012
17
Color vision: a study of essential tremor cases versus normal controls. (22417326)
2012
18
Deep brain stimulation in ireland for Parkinson's disease and essential tremor. (23155918)
2012
19
Decrease in cerebral and cerebellar gray matter in essential tremor: a voxel-based morphometric analysis under 3T MRI. (21447032)
2012
20
Fronto-striatal dysfunction in type 3 familial cortical myoclonic tremor epilepsy occurring during aging. (22736081)
2012
21
Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor. (23036276)
2012
22
Bilateral cerebellorubrothalamic fibers stimulation for essential tremor? (21480371)
2011
23
Update on essential tremor. (22193375)
2011
24
Treatment of patients with essential tremor. (21256454)
2011
25
Adaptive control of deep brain stimulator for essential tremor: entropy-based tremor prediction using surface-EMG. (22256125)
2011
26
SPECT perfusion patterns distinguish psychogenic from essential tremor. (21317018)
2011
27
"Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor. (20142764)
2010
28
Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor. (20670416)
2010
29
LINGO1 and essential tremor: linking the shakes. Linking LINGO1 to essential tremor. (20372187)
2010
30
Mood and motor effects of thalamic deep brain stimulation surgery for essential tremor. (20113336)
2010
31
Movement disorders ii: chorea, dystonia, myoclonus, and tremor. (20595442)
2010
32
Familial cortical myoclonic tremor with epilepsy: the third locus (FCMTE3) maps to 5p. (20548044)
2010
33
Cerebellar atrophy in essential tremor using an automated segmentation method. (19342539)
2009
34
Treatment of fragile-X-associated tremor/ataxia syndrome with deep brain stimulation. (18951504)
2009
35
Dystonic hand tremor in a patient with Wernicke encephalopathy. (19038570)
2009
36
Cerebellar involvement in timing accuracy of rhythmic finger movements in essential tremor. (19912337)
2009
37
Essential tremor and the common LRRK2 G2385R variant. (18316234)
2008
38
Loss of thalamic serotonin transporters in early drug-naA^ve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study. (18335163)
2008
39
Intrafamilial variability in fragile X-associated tremor/ataxia syndrome. (16124012)
2006
40
Fragile X-associated tremor/ataxia syndrome]. (15981162)
2005
41
Sex and tremor location: similarities between essential tremor and cervical dystonia. (15529305)
2005
42
Treatment of phenylketonuria-associated tremor with deep brain stimulation: case report. (15792527)
2005
43
A variant in the HS1-BP3 gene is associated with familial essential tremor. (15699368)
2005
44
Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor/ataxia syndrome. (15060119)
2004
45
Head tremor in dentatorubral-pallidoluysian atrophy. (12371928)
2002
46
Insertional mutation of the Attractin gene in the black tremor hamster. (11773967)
2002
47
Arm tremor in cervical dystonia differs from essential tremor and can be classified by onset age and spread of symptoms. (11522579)
2001
48
Rhythmic tremor of the palate and other cranial limb muscles, with cerebellar ataxia: consider Whipple's disease. (11481720)
2001
49
Force platform recordings in the diagnosis of primary orthostatic tremor. (11166551)
2001
50
Midbrain tremor and hypertrophic olivary degeneration after pontine hemorrhage. (9159743)
1997

Genetic Variations for Tremor

Expression for genes affiliated with Tremor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tremor

Search GEO for disease gene expression data for Tremor.

Pathways for genes affiliated with Tremor

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Tremor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FMR1, USP14, SNCA, LRRK2, PARK2
210.5PARK2, SLC6A3, LRRK2, SNCA
310.5PARK2, SLC6A3, SNCA
4
Hide members
10.5SLC6A3, GABRE, GABRQ, DRD3

Compounds for genes affiliated with Tremor

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Tremor according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1levodopa45 1111.9PARK2, SLC6A3, LRRK2, SNCA, DRD3
2dopamine45 29 11 2413.9PARK2, SLC6A3, LRRK2, GJD2, SNCA, DRD3
36-hydroxydopamine4510.9DRD3, SNCA, SLC6A3, PARK2
4mptp4510.9DRD3, SNCA, SLC6A3, PARK2
51 methyl 4 phenylpyridinium4510.9SNCA, SLC6A3, PARK2
6apomorphine45 29 1112.9SLC6A3, SNCA, DRD3
71-benzyl-1,2,3,4-tetrahydroisoquinoline4510.9SLC6A3, SNCA
8rotenone4510.9SNCA, SLC6A3, PARK2
9methamphetamine45 50 1112.9SLC6A3, SNCA, DRD3
10duloxetine45 50 29 1113.8SLC6A3, DRD3
11catecholamine4510.8DRD3, SNCA, PARK2
12raclopride45 2911.8SLC6A3, DRD3
13dopac4510.8PARK2, DRD3
14piperazine45 1111.8SLC6A3, DRD3
15(+)-bicuculline6010.8GABRQ, GABRE
16(-)-bicuculline methochloride6010.8GABRQ, GABRE
17(-)-bicuculline methiodide6010.7GABRQ, GABRE
18sulpiride45 29 1112.7SLC6A3, DRD3
19sr 95531 hydrobromide6010.7GABRQ, GABRE
20cocaine45 1111.7DRD3, SNCA, SLC6A3
21Clorazepate1110.7GABRE, GABRQ
22pramipexole45 50 29 1113.7SLC6A3, DRD3
23venlafaxine50 45 11 2413.6SLC6A3, GABRQ
24quinpirole45 2911.6SLC6A3, DRD3
25bromazepam45 1111.5GABRQ, GABRE
26nitrazepam45 1111.5GABRQ, GABRE
27Temazepam1110.5GABRE, GABRQ
28flurazepam45 1111.4GABRE, GABRQ
29lorazepam45 50 1112.2GABRE, GABRQ

GO Terms for genes affiliated with Tremor

Sources:
16Gene Ontology
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Biological processes related to Tremor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.7LRRK2, SNCA, DRD3
2positive regulation of dopamine receptor signaling pathwayGO:06016110.7LRRK2, DRD3
3neuron deathGO:07099710.6LRRK2, PARK2
4dopamine biosynthetic processGO:04241610.6SLC6A3, SNCA
5regulation of dopamine secretionGO:01405910.6DRD3, SNCA
6response to cocaineGO:04222010.5SLC6A3, DRD3
7behavioral response to cocaineGO:04814810.5SNCA, DRD3
8negative regulation of oligodendrocyte differentiationGO:04871510.4LINGO1, DRD3
9prepulse inhibitionGO:06013410.2SLC6A3, DRD3

Molecular functions related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1GABA-A receptor activityGO:00489010.5GABRE, GABRQ
2dopamine bindingGO:03524010.2SLC6A3, DRD3

Products for genes affiliated with Tremor

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Sources for Tremor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet