MCID: TRM003
MIFTS: 36

Tremor malady

Summaries for Tremor

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Tremors are unintentional trembling or shaking movements in one or more parts of your body. most tremors occur in the hands. you can also have arm, head, face, vocal cord, trunk, and leg tremors. tremors are most common in middle-aged and older people, but anyone can have them. the cause of tremors is a problem in the parts of the brain that control muscles in the body or in specific parts of the body, such as the hands. they commonly occur in otherwise healthy people. they may also be caused by problems such as parkinson's disease dystonia multiple sclerosis stroke traumatic brain injury alcohol abuse and withdrawal certain medicines some forms are inherited and run in families. others have no known cause. there is no cure for most tremors. treatment to relieve them depends on their cause. in many cases, medicines and sometimes surgical procedures can reduce or stop tremors and improve muscle control. tremors are not life threatening. however, they can be embarrassing and make it hard to perform daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Tremor is related to essential tremor and parkinson's disease. An important gene associated with Tremor is DRD3 (dopamine receptor D3), and among its related pathways are Neuroscience and Parkinsons Disease Pathway. The compounds levodopa and dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and thyroid, and related mouse phenotypes are behavior/neurological and nervous system.

NINDS:43 Tremor is an unintentional, rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. Most tremors occur in the hands, although they can also affect the arms, head, face, voice, trunk, and legs. Sometimes tremor is a symptom of another neurological disorder or a side effect of certain drugs, but the most common form occurs in otherwise healthy people. Some forms of tremor are inherited and run in families, while others have no known cause. Excessive alcohol consumption or alcohol withdrawal can kill certain nerve cells, resulting in tremor, especially in the hand. Other causes include an overactive thyroid and the use of certain drugs. Tremor may occur at any age but is most common in middle-aged and older persons.

Wikipedia:63 A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving to and from... more...

Aliases & Classifications for Tremor

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43NINDS, 33MedlinePlus, 25ICD10
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Related Diseases for Tremor

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17GeneCards, 18GeneDecks
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Diseases in the Essential Tremor family:

tremor

Diseases related to Tremor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 259)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor31.8FMR1, DRD3, GABRQ, SNCA, LINGO1, LINGO4
2parkinson's disease31.2PARK2, DRD3, SLC6A3, LRRK2, SNCA
3dementia30.5PARK2, SLC6A3, FMR1, SNCA, LRRK2
4fragile x-associated tremor/ataxia syndrome30.5FRAXA, FMR1
5multiple system atrophy30.3LRRK2, PARK2, SLC6A3, FMR1, SNCA
6movement disease30.1SNCA, LRRK2
7migraine30.0DRD3, SLC6A3
8progressive supranuclear palsy29.9FUS, SLC6A3
9spinocerebellar ataxia type 329.9SNCA, SLC6A3
10lewy body dementia29.6SNCA, SLC6A3, LRRK2
11tauopathy29.6PARK2, SNCA, LRRK2
12fragile x syndrome10.8
13cervicitis10.4
14brain disease10.4
15primary orthostatic tremor10.4
16multiple sclerosis10.3
17cerebellar ataxia10.3
18neuropathy10.2
19neuronitis10.2
20cerebellar disease10.2
21cerebritis10.1
22alzheimer's disease10.1
23familial dystonia10.1
24tremor hereditary essential, 210.1
25restless legs syndrome10.1
26blepharospasm10.1
27japanese encephalitis10.1
28ophthalmoplegia10.1
29canavan disease10.0
30central pontine myelinolysis10.0
31progressive multifocal leukoencephalopathy10.0
32muscular atrophy10.0
33adult syndrome10.0
34astrocytoma10.0
35leukodystrophy10.0
36spinal muscular atrophy10.0
37spinocerebellar ataxia10.0
38x-linked spinal-bulbar muscle atrophy10.0
39neuroferritinopathy10.0
40spinocerebellar ataxia type 610.0
41neuhauser daly magnelli syndrome10.0
42polymicrogyria turricephaly hypogenitalism10.0
43epilepsy, familial adult myoclonic, 510.0
44sensorineural hearing loss - early graying - essential tremor10.0
45parkinson disease type 310.0LRRK2, PARK2, SNCA
46frontotemporal dementia10.0PARK2, SNCA, FUS, LRRK2
47fmr1-related disorders10.0FMR1
48memory impairment10.0SNCA, SLC6A3, FMR1
49dysautonomia10.0SNCA
50aphasia10.0FUS

Graphical network of the top 20 diseases related to Tremor:



Diseases related to tremor

Clinical Features for Tremor

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Drugs & Therapeutics for Tremor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Tremor

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Anatomical Context for Tremor

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32MalaCards
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MalaCards organs/tissues related to Tremor:

32
Eye, Brain, Thyroid

Animal Models for Tremor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tremor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.6PARK2, SLC6A3, LRRK2, GJD2, SNCA, USP14
2MP:000363110.3FMR1, SLC6A3, LRRK2, GJD2, LINGO1, SNCA

Publications for Tremor

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Genetic Variations for Tremor

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Expression for genes affiliated with Tremor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tremor

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Pathways for genes affiliated with Tremor

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4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Tremor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FMR1, USP14, SNCA, LRRK2, PARK2
210.5PARK2, SLC6A3, LRRK2, SNCA
310.5PARK2, SLC6A3, SNCA
4
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10.5SLC6A3, GABRE, GABRQ, DRD3

Compounds for genes affiliated with Tremor

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Tremor according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1levodopa44 1111.9PARK2, SLC6A3, LRRK2, SNCA, DRD3
2dopamine44 28 11 2413.9PARK2, SLC6A3, LRRK2, GJD2, SNCA, DRD3
36-hydroxydopamine4410.9DRD3, SNCA, SLC6A3, PARK2
4mptp4410.9DRD3, SNCA, SLC6A3, PARK2
51 methyl 4 phenylpyridinium4410.9SNCA, SLC6A3, PARK2
6apomorphine44 28 1112.9SLC6A3, SNCA, DRD3
71-benzyl-1,2,3,4-tetrahydroisoquinoline4410.9SLC6A3, SNCA
8rotenone4410.9SNCA, SLC6A3, PARK2
9methamphetamine44 49 1112.9SLC6A3, SNCA, DRD3
10duloxetine44 49 28 1113.8SLC6A3, DRD3
11catecholamine4410.8DRD3, SNCA, PARK2
12raclopride44 2811.8SLC6A3, DRD3
13dopac4410.8PARK2, DRD3
14piperazine44 1111.8SLC6A3, DRD3
15(+)-bicuculline5910.8GABRQ, GABRE
16(-)-bicuculline methochloride5910.8GABRQ, GABRE
17(-)-bicuculline methiodide5910.7GABRQ, GABRE
18sulpiride44 28 1112.7SLC6A3, DRD3
19sr 95531 hydrobromide5910.7GABRQ, GABRE
20cocaine44 1111.7DRD3, SNCA, SLC6A3
21Clorazepate1110.7GABRE, GABRQ
22pramipexole44 49 28 1113.7SLC6A3, DRD3
23venlafaxine49 44 11 2413.6SLC6A3, GABRQ
24quinpirole44 2811.6SLC6A3, DRD3
25bromazepam44 1111.5GABRQ, GABRE
26nitrazepam44 1111.5GABRQ, GABRE
27Temazepam1110.5GABRE, GABRQ
28flurazepam44 1111.4GABRE, GABRQ
29lorazepam44 49 1112.2GABRE, GABRQ

GO Terms for genes affiliated with Tremor

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16Gene Ontology
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Biological processes related to Tremor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.7LRRK2, SNCA, DRD3
2positive regulation of dopamine receptor signaling pathwayGO:06016110.7LRRK2, DRD3
3neuron deathGO:07099710.6LRRK2, PARK2
4dopamine biosynthetic processGO:04241610.6SLC6A3, SNCA
5regulation of dopamine secretionGO:01405910.6DRD3, SNCA
6response to cocaineGO:04222010.5SLC6A3, DRD3
7behavioral response to cocaineGO:04814810.5SNCA, DRD3
8negative regulation of oligodendrocyte differentiationGO:04871510.4LINGO1, DRD3
9prepulse inhibitionGO:06013410.2SLC6A3, DRD3

Molecular functions related to Tremor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1GABA-A receptor activityGO:00489010.5GABRE, GABRQ
2dopamine bindingGO:03524010.2SLC6A3, DRD3

Products for genes affiliated with Tremor

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Sources for Tremor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet