MCID: TRN004
MIFTS: 38

Trench Fever malady

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 2CDC, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Trench Fever:

Name: Trench Fever 11 13 52 2 37 66
Bartonellosis Due to Bartonella Quintana Infection 52
His-Werner Disease 11
Tibialgic Fever 11
 
Shin Bone Fever 11
Wolhynian Fever 11
Quintan Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:11101
ICD1028 A79.0
ICD9CM30 083.1
MeSH37 D014205
SNOMED-CT60 82214002
Orphanet52 ORPHA64694
ICD10 via Orphanet29 A79.0
MESH via Orphanet38 D014205
UMLS via Orphanet67 C0040830

Summaries for Trench Fever

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Disease Ontology:11 A primary bacterial infectious disease that results in systemic infection, has material basis in bartonella quintana, which is transmitted by body lice (pediculus humanus corporis). the infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary: Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to cat-scratch disease and bartonellosis, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is WARS (Tryptophanyl-TRNA Synthetase), and among its related pathways are Legionellosis and MSP-RON Signaling. Affiliated tissues include bone and testes.

CDC:2 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Wikipedia:69 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

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Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1cat-scratch disease31.5CD40LG, TLR2
2bartonellosis31.1CD40LG, TLR2, TLR4
3sinonasal undifferentiated carcinoma10.6TLR2, TLR4
4atrial septal defect coronary sinus10.6TLR2, TLR4
5antigen-peptide-transporter 2 deficiency10.5TLR2, TLR4
6fanconi syndrome10.5TLR2, TLR4
7pernicious anemia10.5TLR2, TLR4
8gonococcal bursitis10.5CD40LG, TLR4
9toxocariasis10.5TLR2, TLR4
10paraneoplastic polyneuropathy10.5TLR2, TLR4
11spondylohypoplasia, arthrogryposis and popliteal pterygium10.5TLR2, TLR4
12bacteremia10.5TLR2, TLR4
13meibomian cyst10.5CD40LG, TLR4
14gastroduodenal crohn's disease10.5TLR2, TLR4
15gastric hemangioma10.5CD40LG, TLR4
16gallbladder lymphoma10.5TLR2, TLR4
17anal atresia, hypospadias, and penoscrotal inversion10.4TLR2, TLR4
18cholera10.4CD40LG, TLR2
19alkhurma hemorrhagic fever10.4CD40LG, TLR2
20plasmodium malariae malaria10.4CD40LG, WARS
21accessory nerve disease10.4TLR2, TLR4
22invasive pneumococcal disease, recurrent isolated, 110.4TLR2, TLR4
23acute cholangitis10.4TLR2, TLR4
24restless legs syndrome10.4CD40LG, TRW-CCA1-1
25urinary bladder small cell neuroendocrine carcinoma10.4KANTR, TLR4
26endobronchial lipoma10.4CD40LG, TRW-CCA1-1
27melioidosis10.4TLR2, TLR4
28heart disease10.4CD40LG, KANTR
29pompholyx10.3CD40LG, KANTR
30facial nerve neoplasm10.3CD40LG, KANTR
31retroperitoneal fibrosis10.3CD40LG, TLR4
32brachial plexus neuropathy10.3CD40LG, KANTR
33rocky mountain spotted fever10.3CD40LG, KANTR
34urinary schistosomiasis10.3CD40LG, KANTR
35dengue disease10.3TLR2, TLR4
36american histoplasmosis10.3CD40LG, KANTR
37lynch syndrome10.3CD40LG, KANTR
38esophagus melanoma10.3CD40LG, TLR4
39gastric ulcer10.3TLR2, TLR4
40mononeuritis of lower limb10.2TLR2, TLR4
41intestinal pseudo-obstruction10.2CD40LG, KANTR
42parametrium malignant neoplasm10.2CD40LG, TLR2
43typhus10.2
44variola minor10.2TLR2, TLR4
45hepatic vein thrombosis10.2CD40LG, TLR2, TLR4
46abducens nerve neoplasm10.2CD40LG, TLR2, TLR4
47inner ear cancer10.2CD40LG, TLR2, TLR4
48compensatory emphysema10.2CD40LG, TLR2, TLR4
49oesophagostomiasis10.2CD40LG, KANTR
50binocular vision disease10.2CD40LG, TLR2, TLR4

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to trench fever

Symptoms for Trench Fever

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Symptoms:

 11
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

Drugs & Therapeutics for Trench Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Trench Fever


Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

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Anatomical Context for Trench Fever

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MalaCards organs/tissues related to Trench Fever:

34
Bone, Testes

Animal Models for Trench Fever or affiliated genes

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Publications for Trench Fever

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Articles related to Trench Fever:

(show all 50)
idTitleAuthorsYear
1
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. (27375211)
2016
2
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. (27352876)
2016
3
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26075401)
2015
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26000974)
2015
5
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. (24845898)
2014
6
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. (23517327)
2013
7
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. (20973437)
2010
8
Urban trench fever presenting as culture-negative endocarditis. (18835881)
2009
9
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. (17852922)
2008
10
Trench fever: the British medical response in the Great War. (17082300)
2006
11
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. (15472378)
2004
12
Urban trench fever and cat scratch disease. (12684929)
2003
13
From trench fever to endocarditis. (14654579)
2003
14
Urban trench fever in a healthy man from the southeastern United States. (12471587)
2002
15
Bartonella quintana and urban trench fever. (10913410)
2000
16
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. (10476755)
1999
17
Outbreak of epidemic typhus associated with trench fever in Burundi. (9717922)
1998
18
Trench fever among homeless people in Marseille, France: a seroprevalence survey. (9196653)
1997
19
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. (9002093)
1997
20
Q fever and trench fever. (8727131)
1996
21
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. (8779201)
1996
22
Has trench fever returned? (7529896)
1995
23
Return of trench fever. (7853966)
1995
24
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. (2672525)
1989
25
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. (6432481)
1984
26
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. (6742814)
1984
27
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. (351072)
1978
28
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. (417026)
1978
29
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. (63526)
1976
30
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. (5810799)
1969
31
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. (5810798)
1969
32
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. (16562152)
1967
33
In vitro cultivation of the rickettsial agent of trench fever. (5297000)
1966
34
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. (13781520)
1961
35
Relapses in typhus and trench fever]. (13223218)
1954
36
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). (13120859)
1953
37
Trench Fever. (20784435)
1942
38
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. (20474739)
1921
39
Trench Fever: Its Epidemiology and Endemiology. (19981284)
1920
40
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. (20769352)
1919
41
The Association of Rickettsia with Trench Fever. (20474682)
1919
42
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. (20769587)
1919
43
TRENCH FEVER. (20769271)
1918
44
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. (20769186)
1918
45
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). (20768764)
1917
46
TRENCH FEVER AND ITS ALLIES. (20768629)
1917
47
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. (20768479)
1917
48
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. (20768293)
1916
49
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. (20768358)
1916
50
SOME NOTES ON TRENCH FEVER. (20768227)
1916

Variations for Trench Fever

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Expression for genes affiliated with Trench Fever

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Search GEO for disease gene expression data for Trench Fever.

Pathways for genes affiliated with Trench Fever

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GO Terms for genes affiliated with Trench Fever

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Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of plasma membraneGO:003122610.2TLR2, TLR4
2cell surfaceGO:00099868.8CD40LG, SYNJ2BP, TLR2, TLR4

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1regulation of cytokine secretionGO:005070710.3TLR2, TLR4
2positive regulation of chemokine productionGO:003272210.3TLR2, TLR4
3positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR2, TLR4
4MyD88-dependent toll-like receptor signaling pathwayGO:000275510.2TLR2, TLR4
5cellular response to lipoteichoic acidGO:007122310.2TLR2, TLR4
6lipopolysaccharide-mediated signaling pathwayGO:003166310.2TLR2, TLR4
7positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.1TLR2, TLR4
8positive regulation of tumor necrosis factor productionGO:003276010.1TLR2, TLR4
9toll-like receptor signaling pathwayGO:000222410.0TLR2, TLR4
10I-kappaB phosphorylationGO:000725210.0TLR2, TLR4
11positive regulation of interleukin-8 productionGO:00327579.8TLR2, TLR4
12positive regulation of interleukin-6 productionGO:00327559.8TLR2, TLR4
13positive regulation of interleukin-12 productionGO:00327359.8CD40LG, TLR2, TLR4
14positive regulation of interleukin-10 productionGO:00327339.7CD40LG, TLR2, TLR4
15positive regulation of interferon-beta productionGO:00327289.7TLR2, TLR4
16negative regulation of ERK1 and ERK2 cascadeGO:00703739.6SYNJ2BP, TLR4
17positive regulation of NF-kappaB transcription factor activityGO:00510929.5CD40LG, TLR2, TLR4

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:000187510.0TLR2, TLR4
2lipopolysaccharide bindingGO:00015309.8TLR2, TLR4

Sources for Trench Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet