MCID: TRN004
MIFTS: 37

Trench Fever malady

Infectious diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Trench Fever

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 36MeSH, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
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Aliases & Descriptions for Trench Fever:

Name: Trench Fever 10 12 51 2 65 36
Bartonellosis Due to Bartonella Quintana Infection 51
His-Werner Disease 10
Shin Bone Fever 10
 
Wolhynian Fever 10
Tibialgic Fever 10
Quintan Fever 10


Classifications:



External Ids:

Disease Ontology10 DOID:11101
ICD9CM29 083.1
MeSH36 D014205
Orphanet51 64694
SNOMED-CT59 82214002
ICD10 via Orphanet28 A79.0
MESH via Orphanet37 D014205
UMLS via Orphanet66 C0040830
ICD1027 A79.0

Summaries for Trench Fever

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Disease Ontology:10 A primary bacterial infectious disease that results in systemic infection, has material basis in bartonella quintana, which is transmitted by body lice (pediculus humanus corporis). the infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary: Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to relapsing fever and typhus, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is WARS (Tryptophanyl-TRNA Synthetase), and among its related pathways are MSP-RON Signaling and Legionellosis. Affiliated tissues include bone and testes.

Wikipedia:68 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

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Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1relapsing fever10.4
2typhus10.4
3cat-scratch disease10.3
4bartonellosis10.3
5endocarditis10.3
6epidemic typhus10.3
7influenza10.3
8acute conjunctivitis10.2TLR2, TLR4
9protein r deficiency10.2TLR2, TLR4
10agel amyloidosis10.2TLR2, TLR4
11periocular meningioma10.2TLR2, TLR4
12anti-hla hyperimmunization10.2TLR2, TLR4
13hyper-reninism10.2TLR2, TLR4
14uveoparotid fever10.2TLR4, WARS
15radiation cystitis10.2TLR2, TLR4
16pulmonary hemosiderosis10.2CD40LG, TLR4
17chronic polyneuropathy10.2TLR2, TLR4
18neonatal adrenoleukodystrophy10.2TLR2, TLR4
19q fever10.2
20bacillary angiomatosis10.2
21pediculus humanus corporis infestation10.2
22angiomatosis10.2
23pyelonephritis10.2CD40LG, TLR4
24metagonimiasis10.2TLR2, TLR4
25prion disease10.2CD40LG, TLR2
26diversion colitis10.2TLR2, TLR4
27narcissistic personality disorder10.2CD40LG, TLR4
28myelocerebellar disorder10.2TLR2, TLR4
29transient cerebral ischemia10.2CD40LG, TLR2
30irak4 deficiency10.2TLR2, TLR4
31basal cell carcinoma10.2CD40LG, TRW-CCA1-1
32adiaspiromycosis10.2TLR2, TLR4
33melioidosis10.2TLR2, TLR4
34pulmonary edema10.1CD40LG, KANTR
35central sleep apnea10.1CD40LG, KANTR
36sarcoidosis, early-onset10.1TLR2, TLR4
37kidney rhabdoid cancer10.1CD40LG, KANTR
38rocky mountain spotted fever10.1CD40LG, KANTR
39facial paralysis10.1CD40LG, KANTR
40factitious disorder10.1CD40LG, KANTR
41focal labyrinthitis10.1CD40LG, KANTR
42diffuse scleroderma10.1CD40LG, TLR2
43idiopathic spinal cord herniation10.1CD40LG, TLR4
44bubonic plague10.1CD40LG, TLR4
45focal chorioretinitis10.1TLR2, TLR4
46functional gastric disease10.1CD40LG, KANTR
47balanitis10.1TLR2, TLR4
48extratemporal epilepsy10.1CD40LG, KANTR
49supraglottis cancer10.1CD40LG, TLR2, TLR4
50migraine with aura10.1CD40LG, TLR2, TLR4

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to trench fever

Symptoms for Trench Fever

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Symptoms:

 10
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

Drugs & Therapeutics for Trench Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Trench Fever


Cochrane evidence based reviews: Trench Fever

Genetic Tests for Trench Fever

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Anatomical Context for Trench Fever

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MalaCards organs/tissues related to Trench Fever:

33
Bone, Testes

Animal Models for Trench Fever or affiliated genes

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Publications for Trench Fever

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Articles related to Trench Fever:

(show all 47)
idTitleAuthorsYear
1
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26075401)
2015
2
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26000974)
2015
3
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. (24845898)
2014
4
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. (23517327)
2013
5
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. (20973437)
2010
6
Urban trench fever presenting as culture-negative endocarditis. (18835881)
2009
7
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. (17852922)
2008
8
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. (15472378)
2004
9
From trench fever to endocarditis. (14654579)
2003
10
Urban trench fever and cat scratch disease. (12684929)
2003
11
Urban trench fever in a healthy man from the southeastern United States. (12471587)
2002
12
Bartonella quintana and urban trench fever. (10913410)
2000
13
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. (10476755)
1999
14
Outbreak of epidemic typhus associated with trench fever in Burundi. (9717922)
1998
15
Trench fever among homeless people in Marseille, France: a seroprevalence survey. (9196653)
1997
16
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. (9002093)
1997
17
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. (8779201)
1996
18
Q fever and trench fever. (8727131)
1996
19
Has trench fever returned? (7529896)
1995
20
Return of trench fever. (7853966)
1995
21
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. (2672525)
1989
22
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. (6432481)
1984
23
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. (6742814)
1984
24
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. (351072)
1978
25
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. (417026)
1978
26
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. (63526)
1976
27
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. (5810798)
1969
28
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. (5810799)
1969
29
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. (16562152)
1967
30
In vitro cultivation of the rickettsial agent of trench fever. (5297000)
1966
31
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. (13781520)
1961
32
Relapses in typhus and trench fever]. (13223218)
1954
33
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). (13120859)
1953
34
Trench Fever. (20784435)
1942
35
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. (20474739)
1921
36
Trench Fever: Its Epidemiology and Endemiology. (19981284)
1920
37
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. (20769352)
1919
38
The Association of Rickettsia with Trench Fever. (20474682)
1919
39
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. (20769587)
1919
40
TRENCH FEVER. (20769271)
1918
41
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. (20769186)
1918
42
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). (20768764)
1917
43
TRENCH FEVER AND ITS ALLIES. (20768629)
1917
44
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. (20768479)
1917
45
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. (20768358)
1916
46
SOME NOTES ON TRENCH FEVER. (20768227)
1916
47
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. (20768293)
1916

Variations for Trench Fever

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Expression for genes affiliated with Trench Fever

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Search GEO for disease gene expression data for Trench Fever.

Pathways for genes affiliated with Trench Fever

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Pathways related to Trench Fever according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TLR2, TLR4
29.8TLR2, TLR4
39.7CD40LG, TLR4
49.3CD40LG, TLR2, TLR4
5
Show member pathways
9.3CD40LG, TLR2, TLR4
6
Show member pathways
9.3CD40LG, TLR2, TLR4
79.3CD40LG, TLR2, TLR4

GO Terms for genes affiliated with Trench Fever

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Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of plasma membraneGO:00312269.7TLR2, TLR4
2external side of plasma membraneGO:00098979.3CD40LG, TLR2, TLR4

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of dendritic cell cytokine productionGO:000273010.2TLR2, TLR4
2negative regulation of interleukin-17 productionGO:003270010.2TLR2, TLR4
3I-kappaB phosphorylationGO:000725210.2TLR2, TLR4
4positive regulation of chemokine productionGO:003272210.2TLR2, TLR4
5positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.2TLR2, TLR4
6positive regulation of tumor necrosis factor biosynthetic processGO:004253510.2TLR2, TLR4
7positive regulation of interferon-beta productionGO:003272810.2TLR2, TLR4
8positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR2, TLR4
9lipopolysaccharide-mediated signaling pathwayGO:003166310.1TLR2, TLR4
10positive regulation of interleukin-8 productionGO:003275710.0TLR2, TLR4
11positive regulation of macrophage cytokine productionGO:006090710.0TLR2, TLR4
12cellular response to lipoteichoic acidGO:007122310.0TLR2, TLR4
13positive regulation of inflammatory responseGO:00507299.9TLR2, TLR4
14positive regulation of interleukin-6 productionGO:00327559.9TLR2, TLR4
15positive regulation of tumor necrosis factor productionGO:00327609.8TLR2, TLR4
16response to bacteriumGO:00096179.8TLR2, TLR4
17positive regulation of interleukin-12 productionGO:00327359.6CD40LG, TLR2, TLR4
18negative regulation of ERK1 and ERK2 cascadeGO:00703739.6SYNJ2BP, TLR4
19positive regulation of nitric oxide biosynthetic processGO:00454299.5TLR2, TLR4

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00015309.8TLR2, TLR4
2lipopolysaccharide receptor activityGO:00018759.7TLR2, TLR4

Sources for Trench Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet