MCID: TRN004
MIFTS: 41

Trench Fever malady

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

About this section
Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Trench Fever:

Name: Trench Fever 10 12 51 36 2 65
Bartonellosis Due to Bartonella Quintana Infection 51
His-Werner Disease 10
Tibialgic Fever 10
 
Shin Bone Fever 10
Wolhynian Fever 10
Quintan Fever 10

Classifications:



External Ids:

Disease Ontology10 DOID:11101
ICD1027 A79.0
ICD9CM29 083.1
MeSH36 D014205
SNOMED-CT59 82214002
Orphanet51 64694
ICD10 via Orphanet28 A79.0
MESH via Orphanet37 D014205
UMLS via Orphanet66 C0040830
UMLS65 C0040830

Summaries for Trench Fever

About this section
Disease Ontology:10 A primary bacterial infectious disease that results in systemic infection, has material basis in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary: Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to bartonellosis and leukemia, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is WARS (Tryptophanyl-TRNA Synthetase), and among its related pathways are MSP-RON Signaling and A-beta Pathways: Uptake and Degradation. Affiliated tissues include bone, b cells and lung.

CDC:2 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión's disease, caused by B. bacilliformis.

Wikipedia:68 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

About this section

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1bartonellosis28.0CCDC130, CD40LG, CXCL8, SYNJ2BP, TLR2, TLR4
2leukemia10.4
3diarrhea 3, secretory sodium, congenital, syndromic10.4
4carrion's disease10.4
5cat-scratch disease10.4
6pediculus humanus corporis infestation10.4
7lymph node cancer10.3TLR2, TLR4
8protein r deficiency10.3TLR2, TLR4
9exophthalmos10.3TLR2, TLR4
10anti-hla hyperimmunization10.3TLR2, TLR4
11hydrocephalus10.3
12heart disease10.3
13neuronitis10.3
14myeloid leukemia10.3
15basilar artery occlusion10.3TLR4, WARS
16angioid streaks of choroid10.3TLR2, TLR4
17neonatal adrenoleukodystrophy10.3TLR2, TLR4
18breast columnar cell mucinous carcinoma10.3TLR2, TLR4
19scleritis10.3CD40LG, TLR4
20ileocolitis10.3TLR2, TLR4
21myelocerebellar disorder10.3TLR2, TLR4
22invasive pneumococcal disease, recurrent isolated, 110.3TLR2, TLR4
23melioidosis10.3TLR2, TLR4
24keshan disease10.3TLR2, TLR4
25aniseikonia10.2CD40LG, TLR2
26vulvar melanoma10.2CD40LG, TLR2
27hair defect with photosensitivity and mental retardation10.2CXCL8, TLR2
28mycobacterium chelonae10.2CXCL8, TLR2
29tuberculous uveitis10.2CXCL8, TLR2
30acute gonococcal epididymo-orchitis10.2TLR2, TLR4
31scrotum squamous cell carcinoma10.2CXCL8, TLR4
32proliferative glomerulonephritis10.2CD40LG, CXCL8
33meningitis10.2TLR2, TLR4
34occipital lobe neoplasm10.2CXCL8, TLR2
35thrombocytopenia due to platelet alloimmunization10.2CD40LG, TLR2
36lateral sclerosis10.2CD40LG, TLR2
37osteochondrodysplasia10.2CD40LG, CXCL8
38jejunal cancer10.2CD40LG, CXCL8
39xanthogranulomatous pyelonephritis10.2CXCL8, TLR4
40prostate cancer10.2
41renal cell carcinoma10.2
42anorexia nervosa10.2
43hemochromatosis10.2
44chronic venous leg ulcers10.2
45hepatitis10.2
46spondylolisthesis10.2
47lymphoma10.2
48osteomyelitis10.2
49lymphoblastic leukemia10.2
50spastic diplegia10.2

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to trench fever

Symptoms for Trench Fever

About this section

Symptoms:

 10
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

Drugs & Therapeutics for Trench Fever

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Trench Fever


Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

About this section

Anatomical Context for Trench Fever

About this section

MalaCards organs/tissues related to Trench Fever:

33
Bone, B cells, Lung, Colon, Prostate, Tongue, Neutrophil

Animal Models for Trench Fever or affiliated genes

About this section

Publications for Trench Fever

About this section

Articles related to Trench Fever:

(show all 48)
idTitleAuthorsYear
1
Primary cholecystectomy is feasible in elderly patients with acute cholecystitis. (25905472)
2015
2
Blastomyces dermatitidis: Antibody Detection in Sera from Dogs with Blastomycosis with Yeast Lysate Antigens Produced from Human and Dog Isolates. (24724039)
2014
3
SRSF2-P95 Hotspot Mutation is Highly Associated with Advanced Forms of Mastocytosis and Mutations in Epigenetic Regulator Genes. (24389310)
2014
4
Response to "De novo mutation of the TGFB3 latency-associated peptide domain in a patient with overgrowth and Loeys-Dietz syndrome features". (24817670)
2014
5
Catheter closure of patent foramen ovale in patients with cryptogenic cerebrovascular accidents: initial experiences in Japan. (23824518)
2014
6
Better prognosis of patients with glioma expressing FGF2-dependent PDGFRA irrespective of morphological diagnosis. (23630597)
2013
7
Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial. (23453347)
2013
8
Prevalence of and factors associated with osteoporosis among Korean cancer survivors: a cross-sectional analysis of the Fourth and Fifth Korea National Health and Nutrition Examination Surveys. (24083737)
2013
9
Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts. (23234648)
2013
10
Pseudolymphomatous luetic lymphadenitis associated with B cell clonality. (22258795)
2012
11
Clinical characteristics of ulcerative colitis associated with primary sclerosing cholangitis in Korea. (21830268)
2011
12
Neurodegenerative dementia and parkinsonism. (20082052)
2010
13
Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settings. (19759493)
2009
14
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells. (19767773)
2009
15
Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas. (19525928)
2009
16
Foxp3 expression in human cancer cells. (18430198)
2008
17
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. (18342006)
2008
18
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax). (18451169)
2008
19
Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. (18680719)
2008
20
ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. (17620430)
2007
21
A new POLG1 mutation with peo and severe axonal and demyelinating sensory-motor neuropathy. (16715201)
2006
22
Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. (16354694)
2006
23
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. (15546957)
2005
24
Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. (15798195)
2005
25
Inflammatory markers and incident mobility limitation in the elderly. (15209648)
2004
26
Treatment of gastroparesis with electrical stimulation. (12772777)
2003
27
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode. (12667076)
2003
28
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. (11889037)
2002
29
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. (12097647)
2002
30
Response to "Idiopathic hypersomnia: a diagnostic dilemma" (J. Montplaisir and L. Fantini). (12531001)
2001
31
CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses. (10754303)
2000
32
Chickenpox monoarthritis: demonstration of varicella-zoster virus in joint fluid by polymerase chain reaction. (9566673)
1998
33
Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells. (9300715)
1997
34
Hepatocyte growth factor and neutrophil elastase in idiopathic pulmonary fibrosis. (9415350)
1997
35
Neonatal sternal cleft associated with an extrathoracic cystic mass. (9126771)
1997
36
Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes. (9294627)
1997
37
Impairment in the fatty acid composition of keloids. (9547645)
1997
38
Endometrial stromal sarcoma: analysis of treatment failures and survival. (8910635)
1996
39
Total renin after gonadotropin stimulation in polycystic ovarian disease. (7843437)
1995
40
Synergistic effects of fish oil diet and dimethylthiourea in acute adriamycin nephrosis. (7977444)
1994
41
Bilateral pyogenic granuloma of the tongue in graft-versus-host disease: report of case. (7897014)
1994
42
Evidence for excessive Th2 CD4+ subset activity in vivo. (8100845)
1993
43
Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia. (1998645)
1991
44
The response to dietary treatment of patients with chronic post-infectious diarrhea and lactose intolerance. (2358619)
1990
45
Maple syrup urine disease: analysis of branched chain ketoacid decarboxylation in cultured fibroblasts. (1202420)
1975
46
The Boerhaave syndrome associated with carcinoma of the oesophagus. (4767898)
1973
47
The catecholamines in tumor and urine from patients with neuroblastoma, ganglioneuroblastoma and pheochromocytoma. (5655562)
1968
48
Isolation of the virus of lymphogranuloma venereum from twenty-eight patients; relative value of the use of chick embryos and mice. (20998828)
1946

Variations for Trench Fever

About this section

Expression for genes affiliated with Trench Fever

About this section
Search GEO for disease gene expression data for Trench Fever.

Pathways for genes affiliated with Trench Fever

About this section

GO Terms for genes affiliated with Trench Fever

About this section

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.3TLR2, TLR4
2positive regulation of interferon-beta productionGO:003272810.3TLR2, TLR4
3positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.2TLR2, TLR4
4I-kappaB phosphorylationGO:000725210.2TLR2, TLR4
5positive regulation of interleukin-12 productionGO:003273510.2TLR2, TLR4
6positive regulation of tumor necrosis factor productionGO:003276010.1TLR2, TLR4
7toll-like receptor 4 signaling pathwayGO:003414210.1TLR2, TLR4
8positive regulation of interleukin-10 productionGO:003273310.0CD40LG, TLR4
9toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.9TLR2, TLR4
10MyD88-dependent toll-like receptor signaling pathwayGO:00027559.9TLR2, TLR4
11positive regulation of inflammatory responseGO:00507299.8TLR2, TLR4
12cellular response to lipoteichoic acidGO:00712239.8TLR2, TLR4
13lipopolysaccharide-mediated signaling pathwayGO:00316639.8TLR2, TLR4
14negative regulation of ERK1 and ERK2 cascadeGO:00703739.5SYNJ2BP, TLR4
15immune responseGO:00069558.9CXCL8, TLR2, TLR4

Sources for Trench Fever

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet