MCID: TRN004
MIFTS: 38

Trench Fever

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

MalaCards integrated aliases for Trench Fever:

Name: Trench Fever 12 56 3 42 14 69
Bartonellosis Due to Bartonella Quintana Infection 56
His-Werner Disease 12
Shin Bone Fever 12
Tibialgic Fever 12
Wolhynian Fever 12
Quintan Fever 12

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11101
ICD10 33 A79.0
ICD9CM 35 083.1
MeSH 42 D014205
SNOMED-CT 64 82214002
Orphanet 56 ORPHA64694
MESH via Orphanet 43 D014205
UMLS via Orphanet 70 C0040830
ICD10 via Orphanet 34 A79.0
UMLS 69 C0040830

Summaries for Trench Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in systemic infection, has material basis in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary : Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to bartonellosis and cat-scratch disease. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are NF-KappaB Family Pathway and TRAF Pathway. Affiliated tissues include bone and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and digestive/alimentary

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 72 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 bartonellosis 31.9 CD40LG TLR2 TLR4 TNF
2 cat-scratch disease 11.2
3 pediculus humanus corporis infestation 10.9
4 diarrhea 3, secretory sodium, congenital, syndromic 10.9
5 carrion's disease 10.9
6 prothrombin thrombophilia 10.7 TLR2 TLR4
7 fanconi syndrome 10.7 TLR2 TLR4
8 hereditary choroidal atrophy 10.7 TLR2 TLR4
9 gonococcal synovitis 10.7 CD40LG TLR4
10 spondylocostal dysostosis 4 10.7 TLR4 TNF
11 low compliance bladder 10.7 TLR4 TNF
12 neonatal meningitis 10.7 TLR2 TLR4
13 follicular mucinosis 10.7 CD40LG TLR4
14 glycogen storage disease viii 10.7 CD40LG TLR4
15 common cold 10.7 CD40LG TLR4
16 halal setton wang syndrome 10.6 TLR2 TNF
17 lung disease 10.6 CD40LG TNF
18 submandibular gland disease 10.6 CD40LG TNF
19 anal atresia, hypospadias, and penoscrotal inversion 10.6 TLR2 TLR4
20 not otherwise specified 3-mga-uria type 10.6 TLR2 TNF
21 thymus clear cell carcinoma 10.6 TLR2 TLR4
22 mycobacterium kansasii 10.6 TLR2 TNF
23 lateral cystocele 10.6 CD40LG TLR4
24 uveitis 10.6 CD40LG TNF
25 central nervous system leiomyosarcoma 10.6 CD40LG TNF
26 indolent myeloma 10.6 CD40LG TNF
27 ileocolitis 10.6 CD40LG TNF
28 tumefactive multiple sclerosis 10.6 TLR2 TNF
29 dermatomycosis 10.6 CD40LG TNF
30 invasive pneumococcal disease, recurrent isolated, 1 10.6 TLR2 TLR4
31 discitis 10.6 CD40LG TNF
32 tularemia 10.6 CD40LG TNF
33 hypogonadotropism 10.6 CD40LG TNF
34 hepadnavirus infection 10.6 CD40LG TNF
35 bladder diverticulum 10.6 CD40LG TNF
36 functional gastric disease 10.6 CD40LG TNF
37 cellular schwannoma 10.5 CD40LG TNF
38 myelomeningocele 10.5 KANTR TLR4
39 pyridoxine deficiency 10.5 CD40LG TNF
40 functional diarrhea 10.5 CCDC130 CD40LG
41 cryptococcosis 10.5 CD40LG TNF
42 pityriasis rosea 10.5 TLR2 TNF
43 dracunculiasis 10.5 CD40LG TNF
44 spinal canal and spinal cord meningioma 10.5 CD40LG KANTR
45 acute vascular insufficiency of intestine 10.5 CD40LG TNF
46 kidney carcinoma in situ 10.5 CD40LG KANTR
47 facial nerve neoplasm 10.5 CD40LG KANTR
48 myeloid sarcoma 10.5 TLR4 TNF
49 anal colloid adenocarcinoma 10.5 CD40LG KANTR
50 rocky mountain spotted fever 10.5 CD40LG KANTR

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to Trench Fever

Symptoms & Phenotypes for Trench Fever

GenomeRNAi Phenotypes related to Trench Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CD40LG PGLYRP1 TNF TRIM33 WDHD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 PGLYRP1 TNF TRIM33 WDHD1 CD40LG

MGI Mouse Phenotypes related to Trench Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 TLR2 TLR4 TNF TRIM33 PGLYRP1

Drugs & Therapeutics for Trench Fever

Search Clinical Trials , NIH Clinical Center for Trench Fever

Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

Anatomical Context for Trench Fever

MalaCards organs/tissues related to Trench Fever:

39
Bone, Testes

Publications for Trench Fever

Articles related to Trench Fever:

(show all 50)
id Title Authors Year
1
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
2
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. ( 27375211 )
2016
3
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26075401 )
2015
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26000974 )
2015
5
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. ( 24845898 )
2014
6
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. ( 23517327 )
2013
7
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. ( 20973437 )
2010
8
Urban trench fever presenting as culture-negative endocarditis. ( 18835881 )
2009
9
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. ( 17852922 )
2008
10
Trench fever: the British medical response in the Great War. ( 17082300 )
2006
11
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. ( 15472378 )
2004
12
From trench fever to endocarditis. ( 14654579 )
2003
13
Urban trench fever and cat scratch disease. ( 12684929 )
2003
14
Urban trench fever in a healthy man from the southeastern United States. ( 12471587 )
2002
15
Bartonella quintana and urban trench fever. ( 10913410 )
2000
16
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
17
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
18
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. ( 9002093 )
1997
19
Trench fever among homeless people in Marseille, France: a seroprevalence survey. ( 9196653 )
1997
20
Q fever and trench fever. ( 8727131 )
1996
21
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. ( 8779201 )
1996
22
Return of trench fever. ( 7853966 )
1995
23
Has trench fever returned? ( 7529896 )
1995
24
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. ( 2672525 )
1989
25
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. ( 6432481 )
1984
26
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. ( 6742814 )
1984
27
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. ( 351072 )
1978
28
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. ( 417026 )
1978
29
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. ( 63526 )
1976
30
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. ( 5810799 )
1969
31
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. ( 5810798 )
1969
32
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. ( 16562152 )
1967
33
In vitro cultivation of the rickettsial agent of trench fever. ( 5297000 )
1966
34
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. ( 13781520 )
1961
35
[Relapses in typhus and trench fever]. ( 13223218 )
1954
36
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). ( 13120859 )
1953
37
Trench Fever. ( 20784435 )
1942
38
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. ( 20474739 )
1921
39
Trench Fever: Its Epidemiology and Endemiology. ( 19981284 )
1920
40
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. ( 20769352 )
1919
41
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. ( 20769587 )
1919
42
The Association of Rickettsia with Trench Fever. ( 20474682 )
1919
43
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. ( 20769186 )
1918
44
TRENCH FEVER. ( 20769271 )
1918
45
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). ( 20768764 )
1917
46
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. ( 20768479 )
1917
47
TRENCH FEVER AND ITS ALLIES. ( 20768629 )
1917
48
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. ( 20768293 )
1916
49
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. ( 20768358 )
1916
50
SOME NOTES ON TRENCH FEVER. ( 20768227 )
1916

Variations for Trench Fever

Expression for Trench Fever

Search GEO for disease gene expression data for Trench Fever.

Pathways for Trench Fever

GO Terms for Trench Fever

Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.96 TLR2 TLR4
2 cell surface GO:0009986 8.92 CD40LG TLR2 TLR4 TNF

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.86 CD40LG TLR2 TLR4 TNF
2 immune response GO:0006955 9.83 CD40LG PGLYRP1 TLR2 TLR4 TNF
3 defense response to bacterium GO:0042742 9.78 PGLYRP1 TLR4 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.69 PGLYRP1 TLR2 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 CD40LG TLR2 TLR4 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.63 TLR2 TLR4 TNF
7 negative regulation of endothelial cell proliferation GO:0001937 9.61 SYNJ2BP TNF
8 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.6 TLR2 TLR4
9 positive regulation of interferon-beta production GO:0032728 9.59 TLR2 TLR4
10 negative regulation of interleukin-6 production GO:0032715 9.58 TLR4 TNF
11 negative regulation of interferon-gamma production GO:0032689 9.58 PGLYRP1 TLR4
12 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 TLR2 TLR4 TNF
13 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.57 TLR2 TLR4
14 I-kappaB phosphorylation GO:0007252 9.55 TLR2 TLR4
15 regulation of cytokine secretion GO:0050707 9.54 TLR2 TLR4
16 cellular response to lipoteichoic acid GO:0071223 9.52 TLR2 TLR4
17 positive regulation of interleukin-8 production GO:0032757 9.5 TLR2 TLR4 TNF
18 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.49 TLR4 TNF
19 regulation of immunoglobulin secretion GO:0051023 9.48 CD40LG TNF
20 positive regulation of interleukin-12 production GO:0032735 9.43 CD40LG TLR2 TLR4
21 positive regulation of interleukin-10 production GO:0032733 9.33 CD40LG TLR2 TLR4
22 positive regulation of NF-kappaB import into nucleus GO:0042346 9.13 TLR2 TLR4 TNF
23 positive regulation of chemokine production GO:0032722 8.8 TLR2 TLR4 TNF

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.26 CD40LG TNF
2 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
3 peptidoglycan binding GO:0042834 8.96 PGLYRP1 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Trench Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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