MCID: TRN004
MIFTS: 40

Trench Fever malady

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

Aliases & Descriptions for Trench Fever:

Name: Trench Fever 12 56 3 42 14 69
Bartonellosis Due to Bartonella Quintana Infection 56
His-Werner Disease 12
Shin Bone Fever 12
Tibialgic Fever 12
Wolhynian Fever 12
Quintan Fever 12

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11101
ICD10 33 A79.0
ICD9CM 35 083.1
MeSH 42 D014205
SNOMED-CT 64 82214002
Orphanet 56 ORPHA64694
MESH via Orphanet 43 D014205
UMLS via Orphanet 70 C0040830
ICD10 via Orphanet 34 A79.0
UMLS 69 C0040830

Summaries for Trench Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in systemic infection, has material basis in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary : Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to cat-scratch disease and bartonellosis, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are NF-KappaB Family Pathway and TRAF Pathway. Affiliated tissues include bone and testes, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 71 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 cat-scratch disease 11.2
2 bartonellosis 11.2
3 diarrhea 3, secretory sodium, congenital, syndromic 10.9
4 carrion's disease 10.9
5 pediculus humanus corporis infestation 10.9
6 pseudoainhum 10.3 TLR2 TLR4
7 spondylometaphyseal dysplasia east-african type 10.3 TLR4 TNF
8 low compliance bladder 10.3 TLR4 TNF
9 gonococcal synovitis 10.3 CD40LG TLR4
10 primary optic atrophy 10.3 TLR2 TLR4
11 submandibular gland disease 10.2 CD40LG TNF
12 hemangioma of orbit 10.2 CD40LG TNF
13 dermatitis herpetiformis 10.2 CD40LG TNF
14 handl syndrome 10.2 TLR2 TNF
15 human immunodeficiency virus infectious disease 10.2 CD40LG TNF
16 hypertensive heart disease 10.2 CD40LG TLR2 TLR4
17 hyperlucent lung 10.2 CD40LG TLR2 TLR4
18 aortic coarctation 10.2 TLR2 TLR4 TNF
19 aseptic meningitis 10.2 TLR2 TLR4 TNF
20 parasitic ichthyosporea infectious disease 10.2 TLR2 TLR4 TNF
21 crohn's colitis 10.2 TLR2 TLR4 TNF
22 abnormal retinal correspondence 10.2 TLR2 TLR4 TNF
23 inappropriate adh syndrome 10.2 TLR2 TLR4 TNF
24 mansonelliasis 10.2 TLR2 TLR4 TNF
25 unilateral hypoactive labyrinth 10.2 TLR2 TLR4 TNF
26 dengue hemorrhagic fever 10.2 TLR2 TLR4 TNF
27 liver inflammatory pseudotumor 10.2 TLR2 TLR4 TNF
28 congenital hypothyroidism 10.2 CD40LG TLR2 TNF
29 optic nerve hypoplasia 10.2 TLR2 TLR4 TNF
30 immunoglobulin g deficiency 10.2 CD40LG TLR4 TNF
31 myiasis 10.2 CD40LG TLR4 TNF
32 endogenous depression 10.2 CD40LG TLR2 TNF
33 detrusor sphincter dyssynergia 10.2 TLR2 TLR4 TNF
34 disease of mental health 10.2 CD40LG TLR2 TNF
35 erythematosquamous dermatosis 10.2 TLR2 TLR4 TNF
36 atrophy of prostate 10.2 CD40LG TLR2 TNF
37 pulmonary tuberculosis 10.2 CD40LG TLR4 TNF
38 uveitis 10.2 CD40LG TNF
39 uterine adnexa cancer 10.2 CD40LG TLR2 TNF
40 histiocytosis 10.2 TLR2 TLR4 TNF
41 intratubular embryonal carcinoma 10.2 TLR2 TLR4 TNF
42 acute chest syndrome 10.2 CD40LG TLR4 TNF
43 foodborne botulism 10.2 CD40LG TLR2 TNF
44 pulmonary eosinophilia 10.1 CD40LG TLR2 TNF
45 atrial septal defect 6 10.1 CD40LG TLR2 TNF
46 childhood malignant hemangiopericytoma 10.1 CD40LG TLR4 TNF
47 parkinson disease 11 10.1 TLR4 TNF
48 reproductive system disease 10.1 CD40LG TLR2
49 subcorneal pustular dermatosis 10.1 CD40LG TLR2 TNF
50 glycogen storage disease ix 10.1 TLR2 TLR4 TNF

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to Trench Fever

Symptoms & Phenotypes for Trench Fever

Symptoms:

12
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

GenomeRNAi Phenotypes related to Trench Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CD40LG PGLYRP1 TNF TRIM33 WDHD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CD40LG PGLYRP1 TNF TRIM33 WDHD1

Drugs & Therapeutics for Trench Fever

Search Clinical Trials , NIH Clinical Center for Trench Fever

Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

Anatomical Context for Trench Fever

MalaCards organs/tissues related to Trench Fever:

39
Bone, Testes

Publications for Trench Fever

Articles related to Trench Fever:

(show all 50)
id Title Authors Year
1
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
2
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. ( 27375211 )
2016
3
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26075401 )
2015
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26000974 )
2015
5
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. ( 24845898 )
2014
6
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. ( 23517327 )
2013
7
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. ( 20973437 )
2010
8
Urban trench fever presenting as culture-negative endocarditis. ( 18835881 )
2009
9
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. ( 17852922 )
2008
10
Trench fever: the British medical response in the Great War. ( 17082300 )
2006
11
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. ( 15472378 )
2004
12
Urban trench fever and cat scratch disease. ( 12684929 )
2003
13
From trench fever to endocarditis. ( 14654579 )
2003
14
Urban trench fever in a healthy man from the southeastern United States. ( 12471587 )
2002
15
Bartonella quintana and urban trench fever. ( 10913410 )
2000
16
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
17
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
18
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. ( 9002093 )
1997
19
Trench fever among homeless people in Marseille, France: a seroprevalence survey. ( 9196653 )
1997
20
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. ( 8779201 )
1996
21
Q fever and trench fever. ( 8727131 )
1996
22
Has trench fever returned? ( 7529896 )
1995
23
Return of trench fever. ( 7853966 )
1995
24
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. ( 2672525 )
1989
25
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. ( 6432481 )
1984
26
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. ( 6742814 )
1984
27
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. ( 417026 )
1978
28
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. ( 351072 )
1978
29
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. ( 63526 )
1976
30
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. ( 5810798 )
1969
31
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. ( 5810799 )
1969
32
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. ( 16562152 )
1967
33
In vitro cultivation of the rickettsial agent of trench fever. ( 5297000 )
1966
34
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. ( 13781520 )
1961
35
[Relapses in typhus and trench fever]. ( 13223218 )
1954
36
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). ( 13120859 )
1953
37
Trench Fever. ( 20784435 )
1942
38
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. ( 20474739 )
1921
39
Trench Fever: Its Epidemiology and Endemiology. ( 19981284 )
1920
40
The Association of Rickettsia with Trench Fever. ( 20474682 )
1919
41
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. ( 20769587 )
1919
42
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. ( 20769352 )
1919
43
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. ( 20769186 )
1918
44
TRENCH FEVER. ( 20769271 )
1918
45
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. ( 20768479 )
1917
46
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). ( 20768764 )
1917
47
TRENCH FEVER AND ITS ALLIES. ( 20768629 )
1917
48
SOME NOTES ON TRENCH FEVER. ( 20768227 )
1916
49
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. ( 20768293 )
1916
50
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. ( 20768358 )
1916

Variations for Trench Fever

Expression for Trench Fever

Search GEO for disease gene expression data for Trench Fever.

Pathways for Trench Fever

Pathways related to Trench Fever according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 CD40LG TLR2 TLR4 TNF
2
Show member pathways
12.33 CD40LG TLR2 TLR4 TNF
3 12.04 TLR2 TLR4 TNF
4
Show member pathways
12 TLR2 TLR4 TNF
5 11.97 TLR2 TLR4 TNF
6
Show member pathways
11.92 TLR2 TLR4 TNF
7 11.9 TLR2 TLR4 TNF
8
Show member pathways
11.73 CD40LG TLR2 TLR4 TNF
9
Show member pathways
11.66 TLR2 TLR4 TNF
10 11.59 TLR2 TLR4 TNF
11 11.56 CD40LG TLR4 TNF
12 11.5 TLR2 TLR4 TNF
13 11.24 TLR2 TLR4 TNF
14 11.12 CD40LG TLR4
15 11.11 TLR4 TNF
16 11.11 TLR2 TLR4 TNF
17 11.1 CD40LG TLR2 TLR4 TNF
18 10.61 CD40LG TLR2 TLR4 TNF

GO Terms for Trench Fever

Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD40LG TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.87 CD40LG TLR2 TLR4 TNF
2 positive regulation of gene expression GO:0010628 9.86 TLR2 TLR4 TNF WARS
3 immune response GO:0006955 9.85 CD40LG PGLYRP1 TLR2 TLR4 TNF
4 defense response to bacterium GO:0042742 9.8 PGLYRP1 TLR4 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.67 PGLYRP1 TLR2 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 CD40LG TLR2 TLR4 TNF
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 TLR2 TLR4
8 negative regulation of endothelial cell proliferation GO:0001937 9.61 SYNJ2BP TNF
9 positive regulation of interferon-beta production GO:0032728 9.61 TLR2 TLR4
10 positive regulation of interleukin-6 production GO:0032755 9.61 TLR2 TLR4 TNF
11 negative regulation of interferon-gamma production GO:0032689 9.6 PGLYRP1 TLR4
12 negative regulation of interleukin-6 production GO:0032715 9.59 TLR4 TNF
13 positive regulation of protein complex assembly GO:0031334 9.58 TNF WARS
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.58 TLR2 TLR4
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 TLR2 TLR4 TNF
16 I-kappaB phosphorylation GO:0007252 9.55 TLR2 TLR4
17 regulation of cytokine secretion GO:0050707 9.54 TLR2 TLR4
18 cellular response to lipoteichoic acid GO:0071223 9.52 TLR2 TLR4
19 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.51 TLR4 TNF
20 positive regulation of interleukin-8 production GO:0032757 9.5 TLR2 TLR4 TNF
21 regulation of immunoglobulin secretion GO:0051023 9.48 CD40LG TNF
22 positive regulation of interleukin-12 production GO:0032735 9.43 CD40LG TLR2 TLR4
23 positive regulation of interleukin-10 production GO:0032733 9.33 CD40LG TLR2 TLR4
24 positive regulation of NF-kappaB import into nucleus GO:0042346 9.13 TLR2 TLR4 TNF
25 positive regulation of chemokine production GO:0032722 8.8 TLR2 TLR4 TNF

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.26 CD40LG TNF
2 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
3 peptidoglycan binding GO:0042834 8.96 PGLYRP1 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Trench Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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