MCID: TRN004
MIFTS: 40

Trench Fever malady

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Trench Fever:

Name: Trench Fever 11 54 2 39 13 68
Bartonellosis Due to Bartonella Quintana Infection 54
His-Werner Disease 11
Tibialgic Fever 11
 
Shin Bone Fever 11
Wolhynian Fever 11
Quintan Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:11101
ICD1030 A79.0
ICD9CM32 083.1
MeSH39 D014205
SNOMED-CT62 82214002
Orphanet54 ORPHA64694
MESH via Orphanet40 D014205
UMLS via Orphanet69 C0040830
ICD10 via Orphanet31 A79.0

Summaries for Trench Fever

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Disease Ontology:11 A primary bacterial infectious disease that results in systemic infection, has material basis in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary: Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to cat-scratch disease and bartonellosis, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways are A-beta Pathways: Uptake and Degradation and IL-10 Pathway. Affiliated tissues include bone and testes, and related mouse phenotype Synthetic lethal with MLN4924 (a NAE inhibitor).

CDC:2 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia:71 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

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Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1cat-scratch disease11.2
2bartonellosis11.2
3diarrhea 3, secretory sodium, congenital, syndromic10.9
4carrion's disease10.9
5pediculus humanus corporis infestation10.9
6pseudoainhum10.3TLR2, TLR4
7spondylometaphyseal dysplasia east-african type10.3TLR4, TNF
8low compliance bladder10.3TLR4, TNF
9gonococcal synovitis10.3CD40LG, TLR4
10primary optic atrophy10.3TLR2, TLR4
11submandibular gland disease10.2CD40LG, TNF
12hemangioma of orbit10.2CD40LG, TNF
13dermatitis herpetiformis10.2CD40LG, TNF
14handl syndrome10.2TLR2, TNF
15human immunodeficiency virus infectious disease10.2CD40LG, TNF
16hypertensive heart disease10.2CD40LG, TLR2, TLR4
17hyperlucent lung10.2CD40LG, TLR2, TLR4
18aortic coarctation10.2TLR2, TLR4, TNF
19aseptic meningitis10.2TLR2, TLR4, TNF
20parasitic ichthyosporea infectious disease10.2TLR2, TLR4, TNF
21crohn's colitis10.2TLR2, TLR4, TNF
22abnormal retinal correspondence10.2TLR2, TLR4, TNF
23inappropriate adh syndrome10.2TLR2, TLR4, TNF
24mansonelliasis10.2TLR2, TLR4, TNF
25unilateral hypoactive labyrinth10.2TLR2, TLR4, TNF
26dengue hemorrhagic fever10.2TLR2, TLR4, TNF
27liver inflammatory pseudotumor10.2TLR2, TLR4, TNF
28congenital hypothyroidism10.2CD40LG, TLR2, TNF
29optic nerve hypoplasia10.2TLR2, TLR4, TNF
30immunoglobulin g deficiency10.2CD40LG, TLR4, TNF
31myiasis10.2CD40LG, TLR4, TNF
32endogenous depression10.2CD40LG, TLR2, TNF
33detrusor sphincter dyssynergia10.2TLR2, TLR4, TNF
34disease of mental health10.2CD40LG, TLR2, TNF
35erythematosquamous dermatosis10.2TLR2, TLR4, TNF
36atrophy of prostate10.2CD40LG, TLR2, TNF
37pulmonary tuberculosis10.2CD40LG, TLR4, TNF
38uveitis10.2CD40LG, TNF
39uterine adnexa cancer10.2CD40LG, TLR2, TNF
40histiocytosis10.2TLR2, TLR4, TNF
41intratubular embryonal carcinoma10.2TLR2, TLR4, TNF
42acute chest syndrome10.2CD40LG, TLR4, TNF
43foodborne botulism10.2CD40LG, TLR2, TNF
44pulmonary eosinophilia10.1CD40LG, TLR2, TNF
45atrial septal defect 610.1CD40LG, TLR2, TNF
46childhood malignant hemangiopericytoma10.1CD40LG, TLR4, TNF
47parkinson disease 1110.1TLR4, TNF
48reproductive system disease10.1CD40LG, TLR2
49subcorneal pustular dermatosis10.1CD40LG, TLR2, TNF
50glycogen storage disease ix10.1TLR2, TLR4, TNF

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to trench fever

Symptoms & Phenotypes for Trench Fever

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Symptoms:

 11 (show all 4)
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

GenomeRNAi Phenotypes related to Trench Fever according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-15.8CD40LG, PGLYRP1, TNF, TRIM33, WDHD1, CD40LG

Drugs & Therapeutics for Trench Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Trench Fever


Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

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Anatomical Context for Trench Fever

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MalaCards organs/tissues related to Trench Fever:

36
Bone, Testes

Publications for Trench Fever

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Articles related to Trench Fever:

(show all 50)
idTitleAuthorsYear
1
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. (27352876)
2016
2
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. (27375211)
2016
3
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26075401)
2015
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. (26000974)
2015
5
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. (24845898)
2014
6
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. (23517327)
2013
7
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. (20973437)
2010
8
Urban trench fever presenting as culture-negative endocarditis. (18835881)
2009
9
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. (17852922)
2008
10
Trench fever: the British medical response in the Great War. (17082300)
2006
11
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. (15472378)
2004
12
Urban trench fever and cat scratch disease. (12684929)
2003
13
From trench fever to endocarditis. (14654579)
2003
14
Urban trench fever in a healthy man from the southeastern United States. (12471587)
2002
15
Bartonella quintana and urban trench fever. (10913410)
2000
16
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. (10476755)
1999
17
Outbreak of epidemic typhus associated with trench fever in Burundi. (9717922)
1998
18
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. (9002093)
1997
19
Trench fever among homeless people in Marseille, France: a seroprevalence survey. (9196653)
1997
20
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. (8779201)
1996
21
Q fever and trench fever. (8727131)
1996
22
Has trench fever returned? (7529896)
1995
23
Return of trench fever. (7853966)
1995
24
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. (2672525)
1989
25
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. (6432481)
1984
26
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. (6742814)
1984
27
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. (417026)
1978
28
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. (351072)
1978
29
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. (63526)
1976
30
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. (5810798)
1969
31
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. (5810799)
1969
32
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. (16562152)
1967
33
In vitro cultivation of the rickettsial agent of trench fever. (5297000)
1966
34
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. (13781520)
1961
35
Relapses in typhus and trench fever]. (13223218)
1954
36
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). (13120859)
1953
37
Trench Fever. (20784435)
1942
38
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. (20474739)
1921
39
Trench Fever: Its Epidemiology and Endemiology. (19981284)
1920
40
The Association of Rickettsia with Trench Fever. (20474682)
1919
41
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. (20769587)
1919
42
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. (20769352)
1919
43
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. (20769186)
1918
44
TRENCH FEVER. (20769271)
1918
45
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. (20768479)
1917
46
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). (20768764)
1917
47
TRENCH FEVER AND ITS ALLIES. (20768629)
1917
48
SOME NOTES ON TRENCH FEVER. (20768227)
1916
49
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. (20768293)
1916
50
Remarks ON "PYREXIA" OR "TRENCH FEVER.": Based upon Twelve Months' Experience with a Field Ambulance. (20768358)
1916

Variations for Trench Fever

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Expression for genes affiliated with Trench Fever

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Search GEO for disease gene expression data for Trench Fever.

Pathways for genes affiliated with Trench Fever

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Pathways related to Trench Fever according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.9CD40LG, TLR4
29.8TLR4, TNF
39.5TLR2, TLR4, TNF
49.5TLR2, TLR4, TNF
59.5TLR2, TLR4, TNF
6
Show member pathways
9.5TLR2, TLR4, TNF
7
Show member pathways
9.5TLR2, TLR4, TNF
8
Show member pathways
9.5TLR2, TLR4, TNF
99.5TLR2, TLR4, TNF
109.5TLR2, TLR4, TNF
119.5TLR2, TLR4, TNF
129.5TLR2, TLR4, TNF
139.5CD40LG, TLR4, TNF
149.2CD40LG, TLR2, TLR4, TNF
15
Show member pathways
9.2CD40LG, TLR2, TLR4, TNF
16
Show member pathways
9.2CD40LG, TLR2, TLR4, TNF
17
Show member pathways
9.2CD40LG, TLR2, TLR4, TNF
189.2CD40LG, TLR2, TLR4, TNF

GO Terms for genes affiliated with Trench Fever

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Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of plasma membraneGO:00312269.9TLR2, TLR4
2cell surfaceGO:00099869.6CD40LG, TLR2, TLR4, TNF

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:007122310.6TLR2, TLR4
2I-kappaB phosphorylationGO:000725210.6TLR2, TLR4
3MyD88-dependent toll-like receptor signaling pathwayGO:000275510.6TLR2, TLR4
4negative regulation of interleukin-6 productionGO:003271510.5TLR4, TNF
5positive regulation of interferon-beta productionGO:003272810.5TLR2, TLR4
6positive regulation of interleukin-8 biosynthetic processGO:004541610.4TLR4, TNF
7negative regulation of endothelial cell proliferationGO:000193710.4SYNJ2BP, TNF
8negative regulation of interferon-gamma productionGO:003268910.4PGLYRP1, TLR4
9positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.3TLR2, TLR4
10lipopolysaccharide-mediated signaling pathwayGO:003166310.2TLR2, TLR4, TNF
11positive regulation of chemokine productionGO:003272210.2TLR2, TLR4, TNF
12positive regulation of interleukin-10 productionGO:003273310.2CD40LG, TLR2, TLR4
13positive regulation of interleukin-12 productionGO:003273510.2CD40LG, TLR2, TLR4
14positive regulation of interleukin-6 productionGO:003275510.1TLR2, TLR4, TNF
15positive regulation of interleukin-8 productionGO:003275710.1TLR2, TLR4, TNF
16positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR2, TLR4, TNF
17positive regulation of protein complex assemblyGO:003133410.1TNF, WARS
18defense response to bacteriumGO:004274210.1PGLYRP1, TLR4, TNF
19defense response to Gram-positive bacteriumGO:005083010.0PGLYRP1, TLR2, TNF
20regulation of cytokine secretionGO:005070710.0TLR2, TLR4
21inflammatory responseGO:00069549.9CD40LG, TLR2, TLR4, TNF
22regulation of immunoglobulin secretionGO:00510239.8CD40LG, TNF
23positive regulation of gene expressionGO:00106289.8TLR2, TLR4, TNF, WARS
24positive regulation of NF-kappaB transcription factor activityGO:00510929.7CD40LG, TLR2, TLR4, TNF
25immune responseGO:00069559.4CD40LG, PGLYRP1, TLR2, TLR4, TNF

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:000153010.3TLR2, TLR4
2lipopolysaccharide receptor activityGO:000187510.3TLR2, TLR4
3peptidoglycan bindingGO:004283410.1PGLYRP1, TLR2
4tumor necrosis factor receptor bindingGO:00051649.8CD40LG, TNF

Sources for Trench Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet