Trichoepithelioma malady

Wikipedia: Trichoepithelioma is a neoplasm of the adnexa of the skin. Its appearance is similar to basal cell...⁴⁴ more...

MalaCards: Trichoepithelioma is related to multiple familial trichoepithelioma and infiltrative basal cell carcinoma. An important gene associated with Trichoepithelioma is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeleton remodeling_Keratin filaments. The compounds acitretin and fluorochrome have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are mortality/aging and tumorigenesis.

trichoepithelioma 7 43

Diseases related to trichoepithelioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 330)

id	Related Disease	Score	Top Affiliating Genes
1	multiple familial trichoepithelioma	35.2	CDKN2B, PTCH1, CYLD
2	infiltrative basal cell carcinoma	29.7	FAP, KRT20
3	brooke-spiegler syndrome	29.2	VIM, CYLD, KRT8, KRT7
4	basal cell carcinoma	27.2	BCL2, CD34, IVL, MME, MMP11, MKI67
5	squamous cell carcinoma	27.0	CDH1, MKI67, KRT19
6	carcinoma	23.7	VIM, BCL2, CDKN2B, CD34, CDH1, IVL
7	steatocystoma multiplex	13.5	KRT17, KRT10
8	predominantly cortical thymoma	13.5	IVL, KRT14
9	ovarian large-cell neuroendocrine carcinoma	13.4	KRT7, KRT20
10	paraurethral gland neoplasm	13.4	KRT7, KRT20
11	apocrine sweat gland neoplasm	13.4	CD34, KRT14
12	bladder adenocarcinoma	13.4	KRT7, KRT20
13	signet ring cell adenocarcinoma	13.4	KRT7, KRT20
14	mammary paget's disease	13.4	KRT7, KRT20
15	papillary serous adenocarcinoma	13.4	KRT7, KRT20
16	bladder squamous cell carcinoma	13.3	KRT10, KRT14
17	atypical neurofibroma	13.3	CD34, PDPN
18	ovarian brenner tumor	13.3	KRT7, KRT20
19	bile duct adenoma	13.3	KRT7, KRT19
20	anal canal adenocarcinoma	13.3	KRT7, KRT19
21	cholangiolocellular carcinoma	13.3	KRT20, KRT19
22	mucinous cystadenocarcinoma	13.3	KRT7, KRT20
23	keratoderma	13.2	KRT17, KRT10, KRT14
24	ampulla of vater adenocarcinoma	13.2	KRT7, KRT17, KRT20
25	cutaneous paget's disease	13.2	KRT7, KRT20
26	acanthoma	13.2	IVL, KRT10
27	hidradenitis suppurativa	13.2	KRT8, KRT10, KRT14
28	lymphangioma	13.2	CD34, PTCH1, PDPN
29	hidradenitis	13.2	KRT8, KRT10, KRT14
30	inverted papilloma	13.2	MKI67, KRT20
31	pancreatic mucinous cystadenoma	13.2	MME, KRT20
32	mucinous ovarian cystadenoma	13.1	KRT7, KRT20
33	nodular hidradenoma	13.1	VIM, KRT10
34	cutaneous fibrous histiocytoma	13.1	CD34, MMP11
35	spiradenoma	13.1	CYLD, KRT7, KRT15, KRT14
36	dermoid cyst of ovary	13.1	VIM, KRT20
37	skin benign neoplasm	13.1	FAP, PTCH1, KRT20, KRT14
38	pancreatic ductal carcinoma	13.1	KRT8, KRT7, KRT20
39	ovarian mucinous adenocarcinoma	13.1	KRT7, KRT20
40	ichthyosis	13.0	IVL, KRT17, KRT10, KRT14
41	syringocystadenoma papilliferum	13.0	VIM, PTCH1, KRT15
42	middle ear cholesteatoma	13.0	IVL, MKI67, KRT10
43	adenoid squamous cell carcinoma	13.0	VIM, CD34
44	papillary adenoma	13.0	VIM, KRT7
45	skin disease	13.0	IVL, KRT17, KRT10, KRT14
46	hepatic adenoma	13.0	CD34, KRT7, KRT19
47	cervix carcinoma	13.0	MKI67, KRT8, KRT10
48	epithelial-myoepithelial carcinoma	13.0	VIM, KRT14
49	adult acute lymphocytic leukemia	13.0	CDKN2B, CD34, MME
50	dermoid cyst	13.0	VIM, PTCH1, KRT20

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to trichoepithelioma:

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MGI Mouse Phenotypes related to trichoepithelioma:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	7.5	CDH1, KRT14, KRT19, KRT10, KRT17, KRT8
2	tumorigenesis	MP:0002006	7.1	KRT14, BCL2, KRT10, CYLD, PTCH1, MMP11
3	digestive/alimentary phenotype	MP:0005381	6.9	KRT19, KRT17, KRT8, PDPN, CYLD, PTCH1
4	integument phenotype	MP:0010771	6.4	KRT17, KRT19, KRT14, PDPN, CYLD, PTCH1
5	immune system phenotype	MP:0005387	6.0	KRT10, KRT14, CDKN2B, KRT8, PDPN, CYLD

Articles related to trichoepithelioma:

(show all 35)

id	Title	Authors	Year	Affiliating Genes
1	Multiple (familial) trichoepitheliomas: a clinicopath ological and molecular biological study, including CYLD and PTCH gene analysis, of a series of 16 patients. (21389835)	Kazakov D.V.... Michal M.	2011	CYLD, PTCH1
2	Mutation analysis of the CYLD gene in two Chinese fam ilies with multiple familial Trichoepithelioma. (21605102)	Chen M.... Zhang F.	2011	CYLD
3	Immunolabeling pattern of podoplanin (d2-40) may dist inguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. (20559122)	Plaza J.A.... Suster S.	2010	PDPN
4	A novel missense mutation of CYLD gene in a Chinese f amily with multiple familial trichoepithelioma. (19911186)	Wang F.X.... Zhu X.H.	2010	CYLD
5	Fibroblast-activation protein: a single marker that c onfidently differentiates morpheaform/infiltrative basal cell carcinoma from de smoplastic trichoepithelioma. (20711172)	Abbas O.... Mahalingam M.	2010	FAP
6	A novel splicing mutation of the CYLD gene in a Taiwanese family with multiple familial trichoepithelioma. (19076795)	Huang T.M.... Lee J.Y.	2009	CYLD
7	Spectrum of tumors with follicular differentiation in a patient with the clinical phenotype of multiple familial trichoepitheliomas: a clinicopathological and molecular biological study, including analysis of th e CYLD and PTCH genes. (19730223)	Kazakov D.V.... Michal M.	2009	CYLD, PTCH1
8	Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas. (18718192)	Doherty S.D.... Joseph A.K.	2008	CYLD
9	Novel substitution and frameshift mutations of CYLD in two Chinese families with multiple familial trichoepithelioma. (18363762)	Liang Y.H.... Zhang X.J.	2008	CYLD
10	Desmoplastic trichoepithelioma versus morphoeic basal cell carcinoma: a critical reappraisal of histomorphological and immunohistochemical criteria for differentiation. (18462369)	Costache M.... BAPer A.	2008	MKI67, KRT20
11	Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? (18190441)	Katona T.M.... Billings S.D.	2008	KRT20
12	Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (18789069)	Choi C.W.... Cho K.H.	2008	KRT15
13	A novel missense mutation of CYLD gene in a Chinese family with multiple familial trichoepithelioma. (18242958)	Lv H.L.... Zhang X.J.	2008	CYLD
14	Trichoepithelioma. (19061604)	Johnson H.... Sanchez M.	2008	CYLD
15	A novel mutation of CYLD in a Chinese family with multiple familial trichoepithelioma and no CYLD protein expression in the tumour tissue. (17662085)	Zuo Y.G.... Ho M.G.	2007	CYLD
16	A novel missense mutation in the CYLD gene in a Spanish family with multiple familial trichoepithelioma. (17875891)	Espana A.... Garcia-Foncillas J.	2007	CYLD
17	Immunohistochemical assessment of E-cadherin and beta-catenin in trichofolliculomas and trichoepitheliomas. (18345259)	Bezdekova M.... Kolar Z.	2007	CDH1
18	CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes. (16922728)	Young A.L.... Celebi J.T.	2006	CYLD
19	CD10 expression in trichoepithelioma and basal cell carcinoma. (16420307)	Pham T.T.... Herman C.	2006	MME
20	Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China. (16307661)	Liang Y.H.... Zhang X.J.	2005	CYLD
21	Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. (15854031)	Bowen S.... Celebi J.T.	2005	CYLD
22	Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma. (15086550)	Zhang X.J.... Huang W.	2004	CYLD
23	Nonsolitary giant perianal trichoepithelioma with malignant transformation into basal cell carcinoma: report of a case and review of the literature. (15073659)	Martinez C.A.... Waisberg J.	2004	BCL2
24	Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene. (15289313)	Salhi A.... Grzeschik K.H.	2004	CYLD
25	CYLD mutation causes multiple familial trichoepithelioma in three Chinese families. (15024746)	Zheng G.... Kong X.	2004	CYLD
26	Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. (10725363)	Nilsson M.... ToftgAYrd R.	2000	PTCH1
27	Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma. (10215762)	Yamamoto O.... Asahi M.	1999	KRT19, KRT14, KRT17
28	Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells. (10235375)	Jih D.M.... Cotsarelis G.	1999	KRT15
29	Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens. (9550314)	Swanson P.E.... Wick M.R.	1998	BCL2, CD34
30	Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma. (9557781)	Thewes M.... Ring J.	1998	MMP11
31	Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. (9256917)	Verhaegh M.E.... Neumann H.A.	1997	BCL2
32	Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis. (9354420)	VorechovskA1 I.... StAYhle-BAockdahl M.	1997	PTCH1
33	The gene for multiple familial trichoepithelioma maps to chromosome 9p21. (8752837)	Harada H.... Ko M.S.	1996	CDKN2B
34	A nevoid plaque with histological changes of trichoepithelioma and cylindroma in Brooke-Spiegler syndrome. An immunohistochemical study with cytokeratins. (8835176)	Schirren C.G.... Plewig G.	1995	VIM, KRT8, KRT7
35	bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. (8043419)	Smoller B.R.... Warnke R.A.	1994	BCL2

Genes related to trichoepithelioma according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	CYLD	cylindromatosis (turban tumor syndrome)	11.1	Summaries, Publications
2	PTCH1	patched 1	11.1	Publications, Summaries
3	MFT2	Trichoepithelioma, multiple familial, 2	11.1	Aliases & Descriptions
4	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
5	KRT15	keratin 15	11.0	Publications
6	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0	Publications
7	KRT17	keratin 17	11.0	Publications
8	KRT10	keratin 10	11.0	Publications
9	PDPN	podoplanin	11.0	Publications
10	KRT7	keratin 7	11.0	Publications
11	KRT20	keratin 20	11.0	Publications
12	FAP	fibroblast activation protein, alpha	11.0	Publications
13	IVL	involucrin	11.0	Publications
14	KRT14	keratin 14	11.0	Publications
15	CD34	CD34 molecule	11.0	Publications
16	KRT8	keratin 8	11.0	Publications
17	KRT19	keratin 19	11.0	Publications
18	VIM	vimentin	11.0	Publications
19	MME	membrane metallo-endopeptidase	11.0	Publications
20	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
21	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
22	BCL2	B-cell CLL/lymphoma 2	11.0	Publications

Pathways related to trichoepithelioma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling Keratin filaments10	8.3	KRT7, KRT19, KRT8, VIM, KRT14, KRT17
2	Cytoskeleton remodeling_Keratin filaments41	8.1	KRT8, KRT7, KRT17, KRT19, VIM, KRT14
3	Cytoskeletal Signaling3	7.7	KRT19, KRT10, KRT17, KRT7, KRT8, CDH1

Compounds related to trichoepithelioma according to GeneDecks:

(show top 50)    (show all 68)

id	Compound	Score	Top Affiliating Genes
1	acitretin32 9 9	11.9	KRT17, IVL, KRT19
2	fluorochrome32	9.8	KRT10, CD34, VIM
3	reticulin32	9.8	VIM, CD34, KRT7
4	mucicarmine32	9.6	KRT20, KRT7, VIM, KRT14
5	isotretinoin32 9 9	11.6	KRT10, MKI67, KRT14
6	streptavidin32	9.6	KRT20, KRT7, MKI67
7	fitc32	9.5	CD34, KRT19, KRT8
8	arginine32	9.4	MME, KRT14, KRT10, KRT7
9	hydrocortisone32 9 9	11.4	KRT14, KRT17, IVL, VIM
10	calcipotriol32 42 9 9	12.4	KRT14, KRT15, KRT10, IVL, VIM
11	methylcellulose32	9.1	KRT10, CD34, IVL, CDH1
12	cytarabine32 34 9 9	12.1	CDKN2B, VIM, BCL2, MME
13	dutp32	9.0	BCL2, MKI67, KRT10
14	p00332	8.9	CDH1, MKI67, KRT19
15	sodium dodecylsulfate32	8.8	IVL, MKI67, KRT17, CDH1
16	5-aza-2deoxycytidine32	8.7	CDH1, CDKN2B, VIM, KRT7
17	troglitazone32 42 9 9	11.7	CDH1, KRT20, KRT14, BCL2
18	12-o-tetradecanoylphorbol 13-acetate32	8.7	CDH1, MME, MMP11, CD34, IVL
19	vitamin d32	8.5	CDH1, VIM, KRT10, IVL, KRT14
20	iron32 18	9.5	IVL, KRT7, KRT20, KRT19, KRT14, VIM
21	tgf beta132	8.4	CDH1, VIM, CDKN2B, MKI67
22	carbohydrates32	8.4	KRT19, MKI67, CDH1, KRT7
23	doxorubicin32 34 9 9	11.3	VIM, CDH1, KRT8, MKI67, KRT20
24	thymidylate32	8.3	BCL2, CDH1, MKI67, VIM
25	methotrexate32 34 42 9 9	12.2	IVL, CDH1, KRT7, VIM, CDKN2B, MKI67
26	hyaluronic acid32 18	9.2	VIM, CDH1, KRT20, KRT19
27	steroid32	8.1	IVL, MME, KRT19, KRT8, MMP11, MKI67
28	b 72332	8.1	KRT19, VIM, KRT8, KRT7, CDH1, PDPN
29	formaldehyde32 18	9.0	KRT19, KRT20, MKI67, VIM, CDH1, KRT7
30	retinoic acid32 42 18	10.0	KRT19, KRT15, KRT10, KRT8, MMP11, MME
31	glycogen32 18	8.9	KRT7, MKI67, CDH1, KRT19, KRT8, VIM
32	adriamycin32	7.8	KRT8, MME, KRT19, CDH1, VIM, BCL2
33	matrigel32	7.8	KRT8, KRT19, KRT7, FAP, MME, CDH1
34	tamoxifen32 34 9 9	10.7	BCL2, VIM, CDH1, MKI67, KRT8, KRT14
35	cisplatin32 34 9 9	10.7	MKI67, CDH1, KRT8, KRT19, BCL2, KRT14
36	cycloheximide32	7.7	VIM, MKI67, MME, BCL2, KRT19, KRT8
37	butyrate32	7.7	CDH1, VIM, KRT8, BCL2, IVL, KRT14
38	bromodeoxyuridine32	7.7	MKI67, KRT8, KRT10, KRT19, KRT14, MME
39	proline32	7.6	KRT14, KRT10, FAP, MKI67, MMP11, IVL
40	paclitaxel32 34 9 9	10.6	KRT8, KRT19, VIM, BCL2, CDH1, MKI67
41	lactate32	7.4	MKI67, VIM, CDH1, IVL, KRT8, MME
42	estrogen32	7.2	KRT8, CD34, CDH1, IVL, MKI67, KRT10
43	testosterone32 9 18 9	10.1	CDH1, KRT8, KRT7, MME, VIM, MKI67
44	retinoid32	7.0	KRT19, KRT10, KRT8, CDH1, BCL2, VIM
45	hematoxylin32	6.3	KRT20, IVL, KRT14, KRT19, KRT10, KRT8
46	progesterone32 42 9 18 9	9.6	KRT7, KRT8, MMP11, MKI67, CD34, BCL2
47	vegf32	5.6	KRT8, KRT20, KRT19, CDH1, KRT7, PDPN
48	serine32	5.4	KRT19, KRT10, KRT17, KRT8, FAP, KRT14
49	tyrosine32	5.4	PDPN, PTCH1, MKI67, MME, IVL, CDH1
50	paraffin32	4.6	KRT14, KRT19, KRT8, VIM, BCL2, CD34

Cellular components related to trichoepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	keratin filament	GO:045095	9.3	KRT8, KRT7, KRT10, KRT14
2	intermediate filament	GO:005882	7.6	KRT17, KRT8, KRT7, KRT10, KRT15, KRT20
3	cytoplasm	GO:005737	4.7	KRT14, VIM, KRT20, KRT10, BCL2, CDKN2B

Biological processes related to trichoepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament organization	GO:045109	9.8	VIM, KRT20
2	epidermis development	GO:008544	9.5	KRT17, KRT10, KRT15, KRT14
3	response to UV-B	GO:010224	9.4	IVL, BCL2
4	cell-cell adhesion	GO:016337	8.4	PDPN, CDH1, CD34, BCL2

Molecular functions related to trichoepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	9.3	KRT10, KRT7, KRT8, IVL
2	structural constituent of cytoskeleton	GO:005200	8.5	KRT19, KRT20, KRT15, KRT17, VIM, KRT14
3	protein binding	GO:005515	4.4	KRT8, CYLD, PTCH1, KRT7, KRT17, KRT14