TTM
MCID: TRC010
MIFTS: 40

Trichotillomania (TTM) malady

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Trichotillomania

Aliases & Descriptions for Trichotillomania:

Name: Trichotillomania 54 12 50 66 29 13 42 14 69
Hair-Pulling Syndrome 50
Ttm 66

Characteristics:

HPO:

32

Classifications:



External Ids:

OMIM 54 613229
Disease Ontology 12 DOID:0050587
MeSH 42 D014256
ICD10 33 F63.3

Summaries for Trichotillomania

NIH Rare Diseases : 50 trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss (alopecia).  it is classified under the obsessive-compulsive and related disorders category. trichotillomania results in highly variable patterns of hair loss. the scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. the resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). in many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. the disorder may be mild and manageable, or severe and debilitating.  the cause is unknown, though both environmental and genetic causes have been suspected. treatment may involve cognitive behavior therapy, such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective. last updated: 2/24/2017

MalaCards based summary : Trichotillomania, also known as hair-pulling syndrome, is related to obsessive-compulsive disorder and alopecia, and has symptoms including obsessive-compulsive behavior, alopecia and hair-pulling. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and brain.

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM : 54 Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling... (613229) more...

UniProtKB/Swiss-Prot : 66 Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : 71 Trichotillomania (TTM), also known as hair pulling disorder, is an impulse control disorder... more...

Related Diseases for Trichotillomania

Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to Trichotillomania

Symptoms & Phenotypes for Trichotillomania

Symptoms by clinical synopsis from OMIM:

613229

Clinical features from OMIM:

613229

Human phenotypes related to Trichotillomania:

32
id Description HPO Frequency HPO Source Accession
1 obsessive-compulsive behavior 32 HP:0000722
2 alopecia 32 HP:0001596
3 hair-pulling 32 HP:0012167

Drugs & Therapeutics for Trichotillomania

Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
4
Sertraline Approved Phase 4 79617-96-2 68617
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4,Phase 2
9 Neurotransmitter Uptake Inhibitors Phase 4
10 Antiemetics Phase 4
11 Antipsychotic Agents Phase 4
12 Autonomic Agents Phase 4
13 Central Nervous System Depressants Phase 4,Phase 2
14 Gastrointestinal Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Psychotropic Drugs Phase 4,Phase 2
17
Serotonin Phase 4 50-67-9 5202
18 Serotonin Agents Phase 4
19 Serotonin Uptake Inhibitors Phase 4
20 Tranquilizing Agents Phase 4
21 Antidepressive Agents Phase 4,Phase 2
22
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
23
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
24
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078 2978
25
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
27 Narcotic Antagonists Phase 2
28 Narcotics Phase 2
29 Micronutrients Phase 2
30 Trace Elements Phase 2
31 Vitamin B Complex Phase 2
32 Vitamins Phase 2
33 Antidotes Phase 2
34 Anti-Infective Agents Phase 2
35 Antioxidants Phase 2
36 Antiviral Agents Phase 2
37 Expectorants Phase 2
38 N-monoacetylcystine Phase 2
39 Protective Agents Phase 2
40 Respiratory System Agents Phase 2
41 Analgesics Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Cannabinoid Receptor Agonists Phase 2
44 Hallucinogens Phase 2
45 Hormone Antagonists Phase 2
46 Hormones Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
48 Anesthetics Phase 2
49 Anesthetics, Dissociative Phase 2
50 Anesthetics, General Phase 2

Interventional clinical trials:

(show all 36)
id Name Status NCT ID Phase
1 Methylphenidate in ADHD With Trichotillomania Unknown status NCT00552266 Phase 4
2 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4
3 Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania Completed NCT00118014 Phase 4
4 Testing a New Therapy for Trichotillomania Unknown status NCT00872742 Phase 2
5 Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Completed NCT01654523 Phase 2
6 Naltrexone in the Treatment of Trichotillomania Completed NCT00775229 Phase 2
7 Inositol in Trichotillomania Completed NCT01875445 Phase 2
8 N-Acetyl Cysteine in Trichotillomania Completed NCT00354770 Phase 2
9 N-Acetylcysteine for Pediatric Trichotillomania Completed NCT00993265 Phase 2
10 Trichotillomania: Group Cognitive-Behavioral Therapy Completed NCT01968343 Phase 2
11 Cognitive Behavioral Therapy for Trichotillomania Completed NCT00740909 Phase 1, Phase 2
12 Stepped Care in the Treatment of Trichotillomania Completed NCT01118637 Phase 2
13 Marinol in Trichotillomania or Obsessive Compulsive Disorder Completed NCT01093976 Phase 2
14 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2
15 Ketamine Infusion for Obsessive-Compulsive Disorder Completed NCT01349231 Phase 2
16 Milk Thistle in Trichotillomania in Children and Adults Recruiting NCT02473913 Phase 2
17 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder Active, not recruiting NCT01172275 Phase 2
18 Trial of Aripiprazole in Trichotillomania Completed NCT00947154
19 Habit Reversal Training for Children and Adolescents With Trichotillomania Completed NCT01445444
20 Online Treatment of Trichotillomania Completed NCT02044237
21 Efficacy of COMB (Comprehensive Behavioral) Model of Treatment of Trichotillomania Completed NCT01878110
22 Response Inhibition Training for Individuals With Trichotillomania Completed NCT01638975
23 Cognitive Behavioral Treatment of Pediatric Trichotillomania Completed NCT00043563
24 Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions Completed NCT00004550
25 Cortical Excitability in Obsessive-Compulsive and Related Disorders Completed NCT00029068
26 Evaluation of a Brief Surf the Urge Intervention Completed NCT02771886
27 Genetics of Obsessive-Compulsive Disorder Completed NCT00001548
28 Online Response Inhibition Training for Trichotillomania Recruiting NCT01984333
29 Examining Behavior Therapy for Trichotillomania in Children and Adolescents Recruiting NCT00917098
30 Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Recruiting NCT02794753
31 Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania Recruiting NCT02059980
32 Treating Skin Picking With Cognitive-Behavioral Protocol in Individual and Group Format: a Randomized Clinical Trial Recruiting NCT03182478
33 Hair Fall in Patients on Low Dose Methotrexate Recruiting NCT02591823
34 Glutathione Levels and Compulsivity Recruiting NCT02794389
35 Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder) Active, not recruiting NCT02747771
36 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

Genetic Tests for Trichotillomania

Genetic tests related to Trichotillomania:

id Genetic test Affiliating Genes
1 Trichotillomania 29

Anatomical Context for Trichotillomania

MalaCards organs/tissues related to Trichotillomania:

39
Eye, Skin, Brain, Testes

Publications for Trichotillomania

Articles related to Trichotillomania:

(show top 50) (show all 542)
id Title Authors Year
1
Trichoscopic clues for diagnosis of alopecia areata and trichotillomania in Asians. ( 28074524 )
2017
2
Preventing, treating, and predicting barbering: A fundamental role for biomarkers of oxidative stress in a mouse model of Trichotillomania. ( 28426681 )
2017
3
Pharmacotherapy of trichotillomania. ( 28440210 )
2017
4
Modified-Release Methylphenidate-Related Trichotillomania in a Boy with Autism Spectrum Disorder. ( 28394174 )
2017
5
Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment. ( 28118168 )
2017
6
Trichotillomania in Attention-Deficit/Hyperactivity Disorder Under Methylphenidate Treatment. ( 28492426 )
2017
7
Trichotillomania: the impact of treatment history on the outcome of an Internet-based intervention. ( 28461751 )
2017
8
Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata. ( 28225970 )
2017
9
Trichotillomania and Bipolar Disorder. ( 28142271 )
2017
10
Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )
2017
11
Trichotillomania and its clinical relationship to depression and anxiety. ( 28429625 )
2017
12
Videodermoscopy supports the diagnosis of eyelash trichotillomania. ( 28426900 )
2017
13
Trichotillomania and co-occurring anxiety. ( 27668531 )
2017
14
A double-blind, placebo-controlled study of inositol in trichotillomania. ( 27824633 )
2017
15
Trichotillomania, trichophagia, trichobezoar - summary of three cases. Endoscopic follow up scheme in trichotillomania. ( 27086334 )
2016
16
CURRENT AND FUTURE TREATMENTS OF ALOPECIA AREATA AND TRICHOTILLOMANIA IN CHILDREN. ( 27484130 )
2016
17
Trichotillomania and trichophagia - diagnosis, treatment, prevention. The attempt to establish guidelines of treatment in Poland. ( 27086333 )
2016
18
Treating Trichotillomania (Hair-Pulling Disorder) in a Child. ( 27701731 )
2016
19
Investigation of the Phenomenological and Psychopathological Features of Trichotillomania in an Italian Sample. ( 26941700 )
2016
20
Psychosocial dysfunction associated with skin picking disorder and trichotillomania. ( 27137963 )
2016
21
NEO-FFI personality clusters in trichotillomania. ( 27016621 )
2016
22
Sleep-isolated Trichotillomania (SITTM): A Case Report. ( 27413587 )
2016
23
Trichotillomania Among Young Adults: Prevalence and Comorbidity. ( 27827514 )
2016
24
Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl. ( 27477178 )
2016
25
Trichotillomania. ( 27581696 )
2016
26
N-Acetylcysteine in the treatment of trichotillomania: remarkable results in two patients. ( 27146087 )
2016
27
Affective correlates of trichotillomania across the pulling cycle: Findings from an Italian sample of self-identified hair pullers. ( 27836242 )
2016
28
Parent Coping With Adolescent Trichotillomania. ( 27457154 )
2016
29
Affective regulation in trichotillomania before and after self-help interventions. ( 26783728 )
2016
30
IMPAIRED EXECUTIVE FUNCTIONING IN PEDIATRIC TRICHOTILLOMANIA (HAIR PULLING DISORDER). ( 26580849 )
2016
31
Review of Trichotillomania, Skin Picking and Other Body-Focused Repetitive Behaviors, by Jon E. Grant, Dan J. Stein, Douglas W. Woods, and Nancy J. Keuthen. ( 26938709 )
2016
32
DSM-5 Trichotillomania: Perception of Adults With Trichotillomania After Psychosocial Treatment. ( 27724833 )
2016
33
Trichotillomania as a Manifestation of Dementia. ( 27840761 )
2016
34
Trichotillomania and other 'manias': A lesson in inconsistency, selective concern about stigma and political correctness. ( 27389065 )
2016
35
Report of a Rare Case of Alopecia Areata Coexisting with Trichotillomania. ( 27127375 )
2016
36
Predictors of comorbid obsessive-compulsive disorder and skin-picking disorder in trichotillomania. ( 27901519 )
2016
37
Symptom accommodation, trichotillomania-by-proxy, and interpersonal functioning in trichotillomania (hair-pulling disorder). ( 26773995 )
2016
38
Addressing Self-Control Cognitions in the Treatment of Trichotillomania: A Randomized Controlled Trial Comparing Cognitive Therapy to Behaviour Therapy. ( 27471331 )
2016
39
Factor analysis of the Milwaukee Inventory for Subtypes of Trichotillomania-Adult Version. ( 27668153 )
2016
40
N-acetyl cysteine in the treatment of trichotillomania. ( 27891708 )
2016
41
The Phenomenology of Hair Pulling Urges in Trichotillomania: A Comparative Approach. ( 26925017 )
2016
42
Sex differences in trichotillomania. ( 27285392 )
2016
43
Extensive cicatricial alopecia in a patient with long-term trichotillomania. ( 26813077 )
2016
44
Review of available studies of the neurobiology and pharmacotherapeutic management of trichotillomania. ( 26966559 )
2016
45
Trichobezoar (Rapunzel syndrome) in an adolescent patient with Trichotillomania and Generalized Anxiety Disorder: A case report. ( 27969077 )
2016
46
A 'Hairy' problem: Trichotillomania, trichophagia and trichobezoars. ( 27439704 )
2016
47
Comprehensive Behavioral Treatment of Trichotillomania: A Treatment Development Study. ( 26643276 )
2016
48
Trichotillomania in Celiac Disease. ( 27920650 )
2016
49
Pathologic grooming (acne excoriee, trichotillomania, and nail biting) in 4 generations of a single family. ( 27051827 )
2016
50
Defining treatment response in trichotillomania: a signal detection analysis. ( 26422605 )
2015

Variations for Trichotillomania

ClinVar genetic disease variations for Trichotillomania:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SLITRK1 NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs) deletion Pathogenic rs193302861 GRCh37 Chromosome 13, 84454379: 84454379

Expression for Trichotillomania

Search GEO for disease gene expression data for Trichotillomania.

Pathways for Trichotillomania

GO Terms for Trichotillomania

Sources for Trichotillomania

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....