MCID: TRC010
MIFTS: 40

Trichotillomania malady

Rare diseases, Mental diseases categories
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Summaries for Trichotillomania

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NIH Rare Diseases:42 Trichotillomania is an impulse control disorder characterized by an overwhelming urge to repeatedly pull out one's own hair (usually on the scalp), resulting in hair loss (alopecia). the eyelashes, eyebrows, and beard can also be affected. many affected individuals feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. the condition may be mild and manageable, or severe and debilitating. some individuals chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems. the exact cause of the condition is unknown. treatment typically involves psychotherapy (including cognitive behavior therapy) and/or drug therapy, but these are not always effective. last updated: 11/30/2012

MalaCards based summary: Trichotillomania, also known as hair-pulling syndrome, is related to stereotypic movement disorder and obsessive-compulsive disorder, and has symptoms including An important gene associated with Trichotillomania is SLITRK1 (SLIT and NTRK-like family, member 1). Affiliated tissues include skin, brain and testes, and related mouse phenotypes are integument and behavior/neurological.

Disease Ontology:8 An impulse control disorder that involves the uncontrollable plucking of ones hair.

Wikipedia:65 Trichotillomania (pronounced /?tr?k??t?l??me?ni?/ TRIK-?-TIL-?-MAY-NEE-?, also known as trichotillosis... more...

Description from OMIM:46 613229

Aliases & Classifications for Trichotillomania

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Trichotillomania, Aliases & Descriptions:

Name: Trichotillomania 8 9 42 22 46 10 62
 
Hair-Pulling Syndrome 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0050587
OMIM46 613229
ICD1025 F63.3

Related Diseases for Trichotillomania

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Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to trichotillomania

Symptoms for Trichotillomania

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Symptoms by clinical synopsis from OMIM:

613229

Clinical features from OMIM:

613229

HPO human phenotypes related to Trichotillomania:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 obsessive-compulsive behavior HP:0000722
3 multifactorial inheritance HP:0001426
4 alopecia HP:0001596

Drugs & Therapeutics for Trichotillomania

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Drug clinical trials:

Search ClinicalTrials for Trichotillomania

Search NIH Clinical Center for Trichotillomania

Genetic Tests for Trichotillomania

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Genetic tests related to Trichotillomania:

id Genetic test Affiliating Genes
1 Trichotillomania22

Anatomical Context for Trichotillomania

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MalaCards organs/tissues related to Trichotillomania:

32
Skin, Brain, Testes

Animal Models for Trichotillomania or affiliated genes

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MGI Mouse Phenotypes related to Trichotillomania:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5DLGAP3, PRL, HOXB8
2MP:00053867.9SLITRK1, DLGAP3, PRL, HOXB8
3MP:00036317.7HOXB8, PRL, DLGAP3, SLITRK1

Publications for Trichotillomania

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Articles related to Trichotillomania:

(show top 50)    (show all 466)
idTitleAuthorsYear
1
Decreased response monitoring in individuals with symptoms of trichotillomania. (24646325)
2014
2
Measuring the role of psychological inflexibility in Trichotillomania. (25155941)
2014
3
Trichotillomania and emotion regulation: is symptom severity related to alexithymia? (24768249)
2014
4
Trichotillomania in a case of vascular dementia. (23960397)
2013
5
Age and gender correlates of pulling in pediatric trichotillomania. (23452681)
2013
6
The Trichotillomania Impact Project in Young Children (TIP-YC): Clinical Characteristics, Comorbidity, Functional Impairment and Treatment Utilization. (23564261)
2013
7
Disordered reward processing and functional connectivity in trichotillomania: a pilot study. (23777938)
2013
8
Habit reversal training in trichotillomania: guide for the clinician. (23964997)
2013
9
Pediatric trichotillomania. (22437627)
2012
10
Pediatric trichotillomania: clinical presentation, treatment, and implications for nursing professionals. (22525810)
2012
11
Bupropion XL for the sustained treatment of trichotillomania. (22388165)
2012
12
Trichotillomania, bipolar disorder and white matter hyperintensities in a six-year old girl. (22876267)
2012
13
Behavior therapy for pediatric trichotillomania: a randomized controlled trial. (21784296)
2011
14
Masquerading of trichotillomania in a family with monilethrix. (21224181)
2011
15
Trichotillomania following herpetic neuralgia. (20798694)
2010
16
A twin concordance study of trichotillomania. (19199280)
2009
17
Trichotillomania: neurobiology and treatment. (19428495)
2009
18
The use of dermoscopy for the diagnosis of trichotillomania. (19309425)
2009
19
Motor inhibition in trichotillomania and obsessive-compulsive disorder. (17215004)
2008
20
Group treatment for trichotillomania: behavior therapy versus supportive therapy. (17071213)
2006
21
Child abuse and trichotillomania. (15637371)
2005
22
Trichotillomania. (15255326)
2004
23
Affective correlates of trichotillomania. (12384325)
2002
24
A case of resistant trichotillomania treated with risperidone-augmented fluvoxamine. (11320684)
2001
25
Recurrent trichobezoar in a case of trichotillomania. (21407883)
2001
26
Trichotillomania and the mourning process: a case report and review of the psychodynamics. (10593058)
1999
27
Trichotillomania. (10393227)
1999
28
Paroxetine treatment of trichotillomania in an adolescent. (9639081)
1998
29
Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. (9255863)
1997
30
Hypnotherapeutic management of pediatric and adolescent trichotillomania. (8897221)
1996
31
Trichotillomania: ophthalmic presentation. (7619458)
1995
32
Trichotillomania. A common hidden disorder. (7661774)
1995
33
Childhood trichotillomania: clinical phenomenology, comorbidity, and family genetics. (8543512)
1995
34
Efficacy of fluoxetine in trichotillomania. (7849338)
1994
35
Delusional parasitosis with trichotillomania. (7890955)
1994
36
Trichotillomania, clomipramine, topical steroids. (8434676)
1993
37
A simplified behavioral treatment for trichotillomania: report of two cases. (8474824)
1993
38
Response of obsessive-compulsive disorder and trichotillomania to serotonin reuptake blockers. (1728180)
1992
39
Trichotillomania. An obsessive compulsive spectrum disorder? (1461795)
1992
40
Behavioral aspects of trichotillomania. (1474296)
1992
41
Trichotillomania. (3301116)
1987
42
A cognitive-behavioral modification treatment of trichotillomania. (7153436)
1982
43
Treatment of unobserved trichotillomania by attention-reflection and punishment of an apparent covariant. (7166607)
1982
44
The clinical evaluation of pathologic hair loss with a diagnostic sign in trichotillomania. (477397)
1979
45
Trichotillomania: a case report. (6046144)
1967
46
TRICHOTILLOMANIA. (14284875)
1965
47
The psychopathology of trichotillomania and trichophagy. (13936088)
1963
48
Report of two cases of trichotillomania of long standing duration and their response to chlorpromazine. (13539186)
1958
49
Psychosomatic aspects of dermatology with special reference to trichotillomania. (18883262)
1948
50
Trichotillomania. (21064483)
1946

Variations for Trichotillomania

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Clinvar genetic disease variations for Trichotillomania:

6
id Gene Name Type Significance SNP ID Assembly Location
1SLITRK1NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs)deletionPathogenicrs193302861GRCh37Chr 13, 84454379: 84454379

Expression for genes affiliated with Trichotillomania

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Expression patterns in normal tissues for genes affiliated with Trichotillomania

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Pathways for genes affiliated with Trichotillomania

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Compounds for genes affiliated with Trichotillomania

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GO Terms for genes affiliated with Trichotillomania

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Products for genes affiliated with Trichotillomania

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  • Antibodies
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Sources for Trichotillomania

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet