MCID: TRC010
MIFTS: 46

Trichotillomania

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Trichotillomania

MalaCards integrated aliases for Trichotillomania:

Name: Trichotillomania 53 12 72 49 71 36 28 13 41 14 69
Ttm 53 71
Hair-Pulling Syndrome 49

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant
multifactorial

Miscellaneous:
affected individuals can pull hair from any part of the body, including eyelashes and eyebrows
overlap with obsessive-compulsive disorder (ocd, )
overlap with tourette syndrome
affects 1 to 3% of the population
one patient reported with slitrk1 mutation (as of january 2010)


HPO:

31

Classifications:



External Ids:

OMIM 53 613229
Disease Ontology 12 DOID:0050587
MeSH 41 D014256
KEGG 36 H00864
ICD10 32 F63.3
UMLS 69 C0040953

Summaries for Trichotillomania

NIH Rare Diseases : 49 Trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss (alopecia).  It is classified under the obsessive-compulsive and related disorders category. Trichotillomania results in highly variable patterns of hair loss. The scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. The resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. Some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). In many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. The disorder may be mild and manageable, or severe and debilitating.  The cause is unknown, though both environmental and genetic causes have been suspected. Treatment may involve cognitive behavior therapy, such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective. Last updated: 2/24/2017

MalaCards based summary : Trichotillomania, also known as ttm, is related to obsessive-compulsive disorder and impulse control disorder, and has symptoms including alopecia, obsessive-compulsive behavior and hair-pulling. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related phenotype is integument.

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM : 53 Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). (613229)

UniProtKB/Swiss-Prot : 71 Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : 72 Trichotillomania (TTM), also known as hair pulling disorder, is an impulse control disorder... more...

Related Diseases for Trichotillomania

Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to Trichotillomania

Symptoms & Phenotypes for Trichotillomania

Symptoms via clinical synopsis from OMIM:

53
Skin Nails Hair Hair:
alopecia resulting from compulsive hair pulling

Neurologic Behavioral Psychiatric Manifestations:
hair pulling, chronic, compulsive, repetitive
distress and functional impairment resulting from hair pulling behavior


Clinical features from OMIM:

613229

Human phenotypes related to Trichotillomania:

31
# Description HPO Frequency HPO Source Accession
1 alopecia 31 HP:0001596
2 obsessive-compulsive behavior 31 HP:0000722
3 hair-pulling 31 HP:0012167

MGI Mouse Phenotypes related to Trichotillomania:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 ABCB6 DLGAP3 PRL SLITRK5

Drugs & Therapeutics for Trichotillomania

Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
3
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
4
Sertraline Approved Phase 4 79617-96-2 68617
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4,Phase 2
9 Neurotransmitter Uptake Inhibitors Phase 4
10 Antiemetics Phase 4
11 Antipsychotic Agents Phase 4
12 Autonomic Agents Phase 4
13 Central Nervous System Depressants Phase 4,Phase 2
14 Gastrointestinal Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Psychotropic Drugs Phase 4,Phase 2
17
Serotonin Phase 4 50-67-9 5202
18 Serotonin Agents Phase 4
19 Serotonin Uptake Inhibitors Phase 4
20 Tranquilizing Agents Phase 4
21 Antidepressive Agents Phase 4,Phase 2
22
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
23
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
24
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078 2978
25
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
27
Glutamic Acid Approved, Nutraceutical Phase 2 56-86-0 33032
28 Vitamin B Complex Phase 2
29 Micronutrients Phase 2
30 Trace Elements Phase 2
31 Vitamins Phase 2
32 Narcotic Antagonists Phase 2
33 Narcotics Phase 2
34 Antidotes Phase 2
35 Anti-Infective Agents Phase 2
36 Antioxidants Phase 2
37 Antiviral Agents Phase 2
38 Expectorants Phase 2
39 N-monoacetylcystine Phase 2
40 Protective Agents Phase 2
41 Respiratory System Agents Phase 2
42 Analgesics Phase 2
43 Analgesics, Non-Narcotic Phase 2
44 Cannabinoid Receptor Agonists Phase 2
45 Hallucinogens Phase 2
46 Hormone Antagonists Phase 2
47 Hormones Phase 2
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
49 Anesthetics Phase 2
50 Anesthetics, Dissociative Phase 2

Interventional clinical trials:

(show all 37)

# Name Status NCT ID Phase Drugs
1 Methylphenidate in ADHD With Trichotillomania Unknown status NCT00552266 Phase 4 Methylphenidate
2 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
3 Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania Completed NCT00118014 Phase 4 Sertraline
4 Testing a New Therapy for Trichotillomania Unknown status NCT00872742 Phase 2
5 Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Completed NCT01654523 Phase 2
6 Inositol in Trichotillomania Completed NCT01875445 Phase 2 Inositol;Placebo
7 Trichotillomania: Group Cognitive-Behavioral Therapy Completed NCT01968343 Phase 2
8 Naltrexone in the Treatment of Trichotillomania Completed NCT00775229 Phase 2 Naltrexone;Placebo
9 N-Acetylcysteine for Pediatric Trichotillomania Completed NCT00993265 Phase 2 N-Acetylcysteine;Placebo
10 N-Acetyl Cysteine in Trichotillomania Completed NCT00354770 Phase 2 Placebo;N-Acetyl Cysteine
11 Cognitive Behavioral Therapy for Trichotillomania Completed NCT00740909 Phase 1, Phase 2
12 Stepped Care in the Treatment of Trichotillomania Completed NCT01118637 Phase 2
13 Marinol in Trichotillomania or Obsessive Compulsive Disorder Completed NCT01093976 Phase 2 Dronabinol
14 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
15 Ketamine Infusion for Obsessive-Compulsive Disorder Completed NCT01349231 Phase 2 ketamine
16 Milk Thistle in Trichotillomania in Children and Adults Recruiting NCT02473913 Phase 2 Milk Thistle;Placebo
17 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder Active, not recruiting NCT01172275 Phase 2 N-Acetylcysteine;Placebo
18 Hair Fall in Patients on Low Dose Methotrexate Unknown status NCT02591823
19 Habit Reversal Training for Children and Adolescents With Trichotillomania Completed NCT01445444
20 Online Treatment of Trichotillomania Completed NCT02044237
21 Online Response Inhibition Training for Trichotillomania Completed NCT01984333
22 Trial of Aripiprazole in Trichotillomania Completed NCT00947154 aripiprazole
23 Efficacy of COMB (Comprehensive Behavioral) Model of Treatment of Trichotillomania Completed NCT01878110
24 Response Inhibition Training for Individuals With Trichotillomania Completed NCT01638975
25 Examining Behavior Therapy for Trichotillomania in Children and Adolescents Completed NCT00917098
26 Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania Completed NCT02059980
27 Cognitive Behavioral Treatment of Pediatric Trichotillomania Completed NCT00043563
28 Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions Completed NCT00004550
29 Glutathione Levels and Compulsivity Completed NCT02794389 N-acetyl cysteine;Placebo
30 Cortical Excitability in Obsessive-Compulsive and Related Disorders Completed NCT00029068
31 Evaluation of a Brief Surf the Urge Intervention Completed NCT02771886
32 Genetics of Obsessive-Compulsive Disorder Completed NCT00001548
33 Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Recruiting NCT02794753
34 Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder) Active, not recruiting NCT02747771
35 Treating Skin Picking With Cognitive-Behavioral Protocol in Individual and Group Format. Active, not recruiting NCT03182478
36 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672
37 Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children Not yet recruiting NCT03260777

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

Genetic Tests for Trichotillomania

Genetic tests related to Trichotillomania:

# Genetic test Affiliating Genes
1 Trichotillomania 28 SLITRK1

Anatomical Context for Trichotillomania

MalaCards organs/tissues related to Trichotillomania:

38
Skin, Eye, Brain, Testes

Publications for Trichotillomania

Articles related to Trichotillomania:

(show top 50) (show all 562)
# Title Authors Year
1
Types of avoidance in hair-pulling disorder (trichotillomania): An exploratory and confirmatory analysis. ( 29306818 )
2018
2
Computerized response inhibition training for children with trichotillomania. ( 29407564 )
2018
3
Trichotillomania Associated With Aripiprazole: A Case Report. ( 29257789 )
2018
4
Modified-Release Methylphenidate-Related Trichotillomania in a Boy with Autism Spectrum Disorder. ( 28394174 )
2017
5
Videodermoscopy supports the diagnosis of eyelash trichotillomania. ( 28426900 )
2017
6
Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )
2017
7
Trichotillomania and co-occurring anxiety. ( 27668531 )
2017
8
Preventing, treating, and predicting barbering: A fundamental role for biomarkers of oxidative stress in a mouse model of Trichotillomania. ( 28426681 )
2017
9
Predictors of comorbid eating disorders and association with other obsessive-compulsive spectrum disorders in trichotillomania. ( 28667830 )
2017
10
"The girl who pulled her hair"-Positive-affect trichotillomania in a 2-year old child. ( 28784383 )
2017
11
Burnt Matchstick Sign - A new Trichoscopic finding in Trichotillomania. ( 28761268 )
2017
12
Trichotillomania and its clinical relationship to depression and anxiety. ( 28429625 )
2017
13
Sensory over-responsivity in trichotillomania (hair-pulling disorder). ( 29202385 )
2017
14
Trichotillomania in celiac disease patient refractory to iron replacement. ( 28779566 )
2017
15
Pharmacotherapy of trichotillomania. ( 28440210 )
2017
16
Exposure and Ritual Prevention Therapy for Trichotillomania: Two Case Reports. ( 29099553 )
2017
17
Trichotillomania: the impact of treatment history on the outcome of an Internet-based intervention. ( 28461751 )
2017
18
Pathological grooming: Evidence for a single factor behind trichotillomania, skin picking and nail biting. ( 28902896 )
2017
19
Placebo response in trichotillomania. ( 28628502 )
2017
20
Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata. ( 28225970 )
2017
21
Trichoscopic clues for diagnosis of alopecia areata and trichotillomania in Asians. ( 28074524 )
2017
22
"i hair": A prognostic marker in alopecia areata & trichotillomania. ( 29263543 )
2017
23
Trichotillomania: a good response to treatment with N-acetylcysteine. ( 28954106 )
2017
24
Making sense of the role of sense organs in trichotillomania. ( 28827858 )
2017
25
Atomoxetine-Related Trichotillomania in a Boy with Attention-Deficit/Hyperactivity Disorder. ( 29099621 )
2017
26
Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment. ( 28118168 )
2017
27
A Preliminary Investigation of Metacognitive Therapy and Habit Reversal as a Treatment for Trichotillomania. ( 28903787 )
2017
28
Cortical thickness abnormalities in trichotillomania: international multi-site analysis. ( 28664230 )
2017
29
Systematic Review of Published Primary Studies of Neuropsychology and Neuroimaging in Trichotillomania. ( 28835311 )
2017
30
A double-blind, placebo-controlled study of inositol in trichotillomania. ( 27824633 )
2017
31
Trichotillomania and Bipolar Disorder. ( 28142271 )
2017
32
Self-inflicted skin lesions and trichotillomania due to rolled hair. ( 28621120 )
2017
33
Trichotillomania in Attention-Deficit/Hyperactivity Disorder Under Methylphenidate Treatment. ( 28492426 )
2017
34
Clarifying the Relationship between Trichotillomania and Anxiety. ( 28989859 )
2017
35
Addressing Self-Control Cognitions in the Treatment of Trichotillomania: A Randomized Controlled Trial Comparing Cognitive Therapy to Behaviour Therapy. ( 27471331 )
2016
36
Trichotillomania as a Manifestation of Dementia. ( 27840761 )
2016
37
DSM-5 Trichotillomania: Perception of Adults With Trichotillomania After Psychosocial Treatment. ( 27724833 )
2016
38
Parent Coping With Adolescent Trichotillomania. ( 27457154 )
2016
39
Trichotillomania. ( 27581696 )
2016
40
Report of a Rare Case of Alopecia Areata Coexisting with Trichotillomania. ( 27127375 )
2016
41
Affective correlates of trichotillomania across the pulling cycle: Findings from an Italian sample of self-identified hair pullers. ( 27836242 )
2016
42
Trichotillomania in Celiac Disease. ( 27920650 )
2016
43
Review of Trichotillomania, Skin Picking and Other Body-Focused Repetitive Behaviors, by Jon E. Grant, Dan J. Stein, Douglas W. Woods, and Nancy J. Keuthen. ( 26938709 )
2016
44
Psychosocial dysfunction associated with skin picking disorder and trichotillomania. ( 27137963 )
2016
45
Pathologic grooming (acne excoriee, trichotillomania, and nail biting) in 4 generations of a single family. ( 27051827 )
2016
46
Trichotillomania and other 'manias': A lesson in inconsistency, selective concern about stigma and political correctness. ( 27389065 )
2016
47
Symptom accommodation, trichotillomania-by-proxy, and interpersonal functioning in trichotillomania (hair-pulling disorder). ( 26773995 )
2016
48
Factor analysis of the Milwaukee Inventory for Subtypes of Trichotillomania-Adult Version. ( 27668153 )
2016
49
Trichotillomania, trichophagia, trichobezoar - summary of three cases. Endoscopic follow up scheme in trichotillomania. ( 27086334 )
2016
50
CURRENT AND FUTURE TREATMENTS OF ALOPECIA AREATA AND TRICHOTILLOMANIA IN CHILDREN. ( 27484130 )
2016

Variations for Trichotillomania

ClinVar genetic disease variations for Trichotillomania:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLITRK1 NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs) deletion Pathogenic rs193302861 GRCh37 Chromosome 13, 84454379: 84454379

Expression for Trichotillomania

Search GEO for disease gene expression data for Trichotillomania.

Pathways for Trichotillomania

GO Terms for Trichotillomania

Biological processes related to Trichotillomania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.26 SLITRK1 SLITRK5
2 positive regulation of synapse assembly GO:0051965 9.16 SLITRK1 SLITRK5
3 skin development GO:0043588 8.96 ABCB6 SLITRK5
4 adult behavior GO:0030534 8.62 SLITRK1 SLITRK5

Sources for Trichotillomania

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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