Trichuriasis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Trichuriasis

Sources:
⁹Disease Ontology, ⁴CDC, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Disease Ontology:⁹ A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in trichuris trichiura, which is transmitted by ingestion of food contaminated with egg-carrying soil. the infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

MalaCards based summary: Trichuriasis, also known as trichuris trichiura infection, is related to ascariasis and helminthiasis, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is LILRA3 (leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3). The drugs albendazole and mebendazole and the compounds chloramphenicol and heme have been mentioned in the context of this disorder. Affiliated tissues include intestine in humans, colon and t cells.

CDC:⁴ An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide.

Wikipedia:⁶⁴ Trichuriasis also known as whipworm infection is an infection by the parasitic worm Trichuris trichiura... more...

Aliases & Classifications for Trichuriasis

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ²⁸ICD9CM, ²⁶ICD10
See all sources

Trichuriasis, Aliases & Descriptions:

Name: Trichuriasis ⁹ ⁴² ¹¹

Trichuris Trichiura Infection ⁹ ⁶¹

Infection by Trichuris Trichiura ⁶¹

Infection by Trichuris Trichura ⁹

Trichuriasis Infection ⁹

Whipworm Infection ⁴²

Trichocephaliasis ⁴²

Whipworm Disease ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases

ICD10: ²⁶

Certain infectious and parasitic diseases

Helminthiases

Trichuriasis

External Ids:

Disease Ontology⁹ DOID:1252

MeSH³⁴ D014257

SNOMED-CT⁵⁶ 154413002, 3752003, 60570001

ICD9CM²⁸ 127.3

ICD10²⁶ B79

UMLS⁶¹ C0040954

Related Diseases for Trichuriasis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Trichuriasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)

id	Related Disease	Score
1	ascariasis	10.7
2	helminthiasis	10.4
3	atopy	10.4
4	enterobiasis	10.1
5	ancylostomiasis	10.1
6	strongyloidiasis	10.1
7	colitis	10.1
8	deficiency anemia	10.0
9	hemolytic anemia	10.0
10	malaria	10.0
11	necatoriasis	10.0
12	scurvy	10.0
13	typhoid fever	10.0
14	rectal prolapse	10.0
15	iron deficiency anemia	10.0
16	yellow fever	10.0
17	hymenolepiasis	10.0
18	tungiasis	10.0
19	gastroenteritis	10.0
20	schistosomiasis	10.0
21	ankylostomiasis	10.0

Graphical network of the top 20 diseases related to Trichuriasis:

Symptoms for Trichuriasis

Sources:
⁹Disease Ontology
See all sources

Symptoms:

⁹

abdominal pain
diarrhea

rectal prolapse
growth retardation

Drugs & Therapeutics for Trichuriasis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Trichuriasis

Search NIH Clinical Center for Trichuriasis

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

Genetic Tests for Trichuriasis

Anatomical Context for Trichuriasis

Sources:
³²MalaCards, ¹⁵FMA
See all sources

MalaCards organs/tissues related to Trichuriasis:

³²

Colon, T cells

FMA organs/tissues related to Trichuriasis:

¹⁵

Intestine in humans

Animal Models for Trichuriasis or affiliated genes

Publications for Trichuriasis

Sources:
⁵¹PubMed
See all sources

Articles related to Trichuriasis:

(show top 50) (show all 97)

id	Title	Authors	Year
1	Growth reduction among primary schoolchildren with light trichuriasis in Malaysia treated with albendazole. (23682433)	Tee M.H.... Raj S.M.	2013
2	Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. (23523058)	Wang D.D.... An C.L.	2013
3	Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. (22041638)	Scholte R.G.... Carvalho O.S.	2012
4	Household social determinants of ascariasis and trichuriasis in North Central Venezuela. (24029148)	Quintero K.... Rodriguez-Morales A.J.	2012
5	Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. (21666788)	Reina Ortiz M.... Cooper P.J.	2011
6	Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. (20700138)	Quihui-Cota L.... Diaz-Camacho S.P.	2010
7	Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. (16679166)	Bethony J.... Hotez P.J.	2006
8	Computed tomographic findings of trichuriasis. (16830393)	Tokmak N.... Bal N.	2006
9	Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. (15293971)	Legesse M.... Medhin G.	2004
10	Trichuriasis: localized inflammatory responses in the colon. (12236416)	Kaur G.... Naing N.N.	2002
11	Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. (11865424)	Faulkner H.... BRADLEY J.E.	2002
12	Efficacy of multiple dose mebendazole against trichuriasis in Thai and Karen patients. (11289001)	Nontasut P.... Muennoo C.	2000
13	Use of Fenbendazole in Treating Trichuriasis in Colobus Monkeys. (23985619)	Carr R.S.... Aguilar R.F.	1999
14	Ascariasis, trichuriasis, and growth of schoolchildren in Northeastern Peninsular Malaysia. (10772554)	Raj S.M.... Naing N.N.	1998
15	Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model. (7974660)	Jenkins D.... Wakelin D.	1994
16	Ascariasis and trichuriasis in Cameroon. (2068772)	Ratard R.C.... Cline B.L.	1991
17	Helper T-cell subsets in mouse trichuriasis. (15463401)	Else K.J.... Grencis R.K.	1991
18	Trichuris and trichuriasis in humans. (2683614)	Bundy D.A.... Cooper E.S.	1989
19	Host predisposition to trichuriasis: the mouse--T. muris model. (2762038)	Else K.J.... Roach T.I.	1989
20	The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. (3250338)	Bundy D.A.... Cooper E.S.	1988
21	Gastric trichuriasis in a black and white colobus monkey. (3505990)	Loomis M.R.... Wright J.F.	1986
22	Cortisone-induced immunotolerance to nematode infection in CBA/Ca mice. II. A model for human chronic trichuriasis. (6826206)	Lee T.D.... Wakelin D.	1983
23	Safety and efficacy of diphetarsone in the treatment of amoebiasis, non-pathogenic amoebiasis and trichuriasis. (6304952)	Keystone J.S.... McIntyre L.	1983
24	Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiases. (7332916)	Yangco B.G.... Craig C.P.	1981
25	Evaluation of mebendazole in trichuriasis. (7228360)	Dalal N.J.... Shah P.N.	1980
26	Trichuriasis. Roentgenographic features and differential diagnosis with lymphoid hyperplasia. (450490)	Manzano C.... Valenzuela C.	1979
27	Is trichuriasis associated with iron deficiency anemia? (464198)	Greenberg E.R.... Cline B.L.	1979
28	Further experience with mebendazole in the treatment of symptomatic trichuriasis in children. (646017)	Scragg J.N.... Proctor E.M.	1978
29	Mebendazole in the treatment of severe symptomatic trichuriasis in children. (848642)	Scragg J.N.... Proctor E.M.	1977
30	Pathophysiology of swine trichuriasis. (883715)	Batte E.G.... Vestal T.J.	1977
31	Treatment for trichuriasis with oxantel. (1008134)	Garcia E.G.	1976
32	Algorithms in the diagnosis and management of exotic diseases. IX. Trichuriasis. (1245771)	Warren K.S.... Mahmoud A.A.	1976
33	Trichuriasis in Calcasieu Parish, Southwest Louisiana. (1185028)	Farhadian H.... Schneider E.A.	1975
34	Treatment of trichuriasis with a new drug, mebendazole. (1113237)	Maqbool S.... Katz M.	1975
35	A clinical evaluation of the efficacy of mebendazole in the treatment of trichuriasis. (1098155)	Sargent R.G.... Lee P.R.	1975
36	Mebendazole. Treatment of trichuriasis and ascariasis in Bahamian children. (4479643)	Wolfe M.S.... Wershing J.M.	1974
37	Diphetarsone in trichuriasis. (4814638)	Kidney J.G.	1974
38	Clinical trichuriasis produced experimentally in growing pigs. II. Anthelmintic efficacy of dichlorvos. (4519451)	Beer R.J.... Curran M.K.	1973
39	Prevalence of human ascariasis and trichuriasis in San Juan and vicinity, Puerto Rico. (4711667)	Acholonu A.D.	1973
40	Dichlorvos: an anthelmintic for primate trichuriasis. (4249649)	Pryor W.H.... Raulston G.L.	1970
41	Rectal prolapse in children with trichuriasis. (5980975)	Soriano L.R.... Naguit-Sim L.	1966
42	Trichuriasis. (5863191)	Vyas K.J.	1965
43	THE THERAPY OF TRICHURIASIS WITH A COMBINATION OF THIABENDAZOLE AND PYRVINIUM PAMOATE. (14317649)	VILELAMDE P.... Iglesias J.	1965
44	STILBAZIUM IODIDE (MONOPAR) IN THE TREATMENT OF HUMAN TRICHURIASIS. (14336083)	MALDONADO J.F.	1965
45	A TETRACHLORETHYLENE-CHENOPODIUM PREPARATION IN TRICHURIASIS. (14073709)	DELMUNDO F.... TALABIS S.M.	1963
46	Experimental trichuriasis. II. Anthelmintic screening against Trichuris muris in the albino mouse. (13752160)	KEELING J.E.	1961
47	Experimental trichuriasis. I. Antagonism between Trichuris muris and Aspiculuris tetraptera in the albino mouse. (13752159)	KEELING J.E.	1961
48	Effect of dithiazanine in ascariasis, trichuriasis, enterobiasis and ankylostomiasis. (13924257)	Vakil B.J.... MEHTA B.J.	1961
49	Therapy of trichuriasis and ancylostomiasis with dithiazanine. (13698988)	FERNANDO P.V.	1960
50	Treatment of trichuriasis with dithiazanine; a preliminary report. (13608089)	PAINE D.H.... COOPER T.V.	1959

Genes related to Trichuriasis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Trichuriasis:

- Elite gene

id	Symbol	Description	Score	Implication
1	LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	21.56	GeneCards inferred via : Publications (show sections)
2	PROK2	prokineticin 2	18.23	GeneCards inferred via : Publications (show sections)
3	HBE1	hemoglobin, epsilon 1	14.89	GeneCards inferred via : Publications (show sections)
4	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.56	GeneCards inferred via : Publications (show sections)
5	PI3	peptidase inhibitor 3, skin-derived	8.23	GeneCards inferred via : Publications (show sections)
6	CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	4.89	GeneCards inferred via : Publications (show sections)

Products for genes related to Trichuriasis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	6	-	6	5
2	Novus Biologicals	6	4	5	-

Variations for Trichuriasis

Expression for genes affiliated with Trichuriasis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Trichuriasis

Search GEO for disease gene expression data for Trichuriasis.

Pathways for genes affiliated with Trichuriasis

Compounds for genes affiliated with Trichuriasis

Sources:
⁴⁴Novoseek, ³BitterDB, ⁵⁰PharmGKB, ¹²DrugBank, ²⁹IUPHAR, ²⁵HMDB
See all sources

Compounds related to Trichuriasis according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	chloramphenicol⁴⁴ ³ ⁵⁰ ¹²	12.1	HBE1, PI3
2	heme²⁹ ²⁵ ¹²	11.1	HBE1, CYP4F3

GO Terms for genes affiliated with Trichuriasis

Sources:
¹⁷Gene Ontology
See all sources

Molecular functions related to Trichuriasis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	iron ion binding	GO:005506	9.4	HBE1, CYP4F3
2	heme binding	GO:020037	9.1	HBE1, CYP4F3

Products for genes affiliated with Trichuriasis

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Trichuriasis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: TRC012 MIFTS: 46	Trichuriasis malady Rare diseases, Infectious diseases, Gastrointestinal diseases categories
4 symptoms, 5 drugs, 6 genes, 3 tissues, 21 related diseases, clinical trials Download this MalaCard Expand all tables

Trichuriasis malady