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MCID: TRC012
MIFTS: 50

Trichuriasis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trichuriasis

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MalaCards integrated aliases for Trichuriasis:

Name: Trichuriasis 12 49 3 41 14
Whipworm Infection 49 3
Infection by Trichuris Trichiura 69
Infection by Trichuris Trichura 12
Trichuris Trichiura Infection 12
Trichuriasis Infection 12
Trichocephaliasis 49
Whipworm Disease 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1252
ICD10 32 B79
ICD9CM 34 127.3
MeSH 41 D014257
UMLS 69 C0040954
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Summaries for Trichuriasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

MalaCards based summary : Trichuriasis, also known as whipworm infection, is related to enterobiasis and schistosomiasis, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is IL9 (Interleukin 9), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Piperazine and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include intestine in humans, colon and t cells.

CDC : 3 An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide.

Wikipedia : 72 Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris... more...

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Related Diseases for Trichuriasis

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Diseases related to Trichuriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 30.4 IL13 IL9
2 schistosomiasis 29.8 IL10 IL13 TNF
3 necatoriasis 29.6 CXCL8 IL10
4 parasitic helminthiasis infectious disease 29.5 IL10 IL13 STH TNF
5 colitis 29.4 CXCL8 IL10 TNF
6 tungiasis 29.3 CXCL8 IL10 TNF
7 gastroenteritis 29.2 CXCL8 IL10 TNF
8 malaria 28.4 CXCL8 IL10 IL13 IL9 TNF
9 cytokine deficiency 10.5 IL13 IL9
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL13 TNF
11 actinic prurigo 10.4 IL13 TNF
12 apple allergy 10.4 IL10 IL13
13 beta-lactam allergy 10.4 IL10 IL13
14 punctate inner choroidopathy 10.4 IL10 TNF
15 myelitis 10.4 IL9 TNF
16 peanut allergy 10.3 IL10 IL13
17 radiculopathy 10.3 IL10 IL13
18 tropical endomyocardial fibrosis 10.3 IL10 TNF
19 microscopic polyangiitis 10.3 IL10 TNF
20 multifocal choroiditis 10.3 IL10 TNF
21 endomyocardial fibrosis 10.3 IL10 TNF
22 transient hypogammaglobulinemia 10.3 IL10 TNF
23 choroiditis 10.3 IL10 TNF
24 mucocutaneous leishmaniasis 10.3 IL10 TNF
25 lipoid nephrosis 10.3 IL10 IL13
26 idiopathic achalasia 10.3 IL10 TNF
27 orofacial granulomatosis 10.3 IL10 TNF
28 poliomyelitis 10.3 IL10 TNF
29 primary systemic mycosis 10.3 IL10 TNF
30 intermediate uveitis 10.3 IL10 TNF
31 multidrug-resistant tuberculosis 10.3 IL10 TNF
32 post-transplant lymphoproliferative disease 10.3 IL10 TNF
33 coccidiosis 10.3 IL10 TNF
34 eales disease 10.3 IL10 TNF
35 hemorrhagic fever 10.3 IL10 TNF
36 paranasal sinus disease 10.3 IL10 IL13
37 spotted fever 10.3 IL10 TNF
38 hematopoietic stem cell transplantation 10.3 IL10 TNF
39 panuveitis 10.3 IL10 TNF
40 scrub typhus 10.3 IL10 TNF
41 plasmodium vivax malaria 10.3 IL10 TNF
42 q fever 10.3 IL10 TNF
43 aphthous stomatitis 10.3 IL10 TNF
44 epstein-barr virus-associated gastric carcinoma 10.3 IL10 TNF
45 churg-strauss syndrome 10.2 IL10 TNF
46 severe hemophilia a 10.2 IL10 TNF
47 lepromatous leprosy 10.2 IL10 TNF
48 immune suppression 10.2 IDO1 IL10
49 hemorrhagic fever with renal syndrome 10.2 IL10 TNF
50 extrinsic cardiomyopathy 10.2 IL10 TNF

Graphical network of the top 20 diseases related to Trichuriasis:



Diseases related to Trichuriasis
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Symptoms & Phenotypes for Trichuriasis

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Symptoms:

12
  • • abdominal pain
  • • diarrhea
  • • rectal prolapse
  • • growth retardation
Sources

Drugs & Therapeutics for Trichuriasis

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Drugs for Trichuriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Piperazine Approved, Vet_approved Phase 4,Phase 3 110-85-0 4837
2
Mebendazole Approved, Vet_approved Phase 4,Phase 3 31431-39-7 4030
3
Albendazole Approved, Vet_approved Phase 4,Phase 2 54965-21-8 2082
4 Pyrantel Approved, Vet_approved Phase 4
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
6 Adjuvants, Immunologic Phase 4
7 Neuromuscular Agents Phase 4
8 Neuromuscular Blocking Agents Phase 4
9 Neuromuscular Depolarizing Agents Phase 4
10 Oxantel Phase 4
11 Anthelmintics Phase 4,Phase 3,Phase 2
12 Peripheral Nervous System Agents Phase 4
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Piperazine citrate Phase 4,Phase 3
15 Antimitotic Agents Phase 4,Phase 3,Phase 2
16 Pyrantel Pamoate Phase 4
17 Antiprotozoal Agents Phase 4,Phase 2
18 Antiparasitic Agents Phase 4,Phase 3,Phase 2
19 Antirheumatic Agents Phase 4
20 Citrate Nutraceutical Phase 4,Phase 3
21 Vaccines Phase 2
22 Pharmaceutical Solutions Phase 2
23
Oxfendazole Phase 2 53716-50-0 40854
24 Cayenne Nutraceutical Phase 2
25
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 46936176 6474909
26
Praziquantel Approved, Investigational, Vet_approved 55268-74-1 4891

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4 Albendazole, 2 x 400mg;Albendazole 400mg;Mebendazole 500mg;Mebendazole 2 x 500mg;Pyrantel-oxantel + mebendazole
2 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4 Albendazole;Levamisole
3 A Safety Study of Mebendazole in Children 2 to 10 Years of Age Completed NCT01173562 Phase 3 Mebendazole
4 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
5 Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease Completed NCT01279577 Phase 2 Low dose TSO;Medium dose TSO;High dose TSO;Placebo
6 Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults Not yet recruiting NCT03435718 Phase 2 Oxfendazole;Albendazole
7 Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults Not yet recruiting NCT02636803 Phase 2 oxfendazole;albendazole
8 TSO in Pediatric Autistic Spectrum Disorders Terminated NCT01734941 Phase 2 TSO;Placebo
9 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
10 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
11 Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression Completed NCT00507221 Albendazole;Praziquantel;Current standard of care in Kenya
12 Immune Modulation From Trichuris Suis Completed NCT03079700
13 Immune Modulation From Trichuris Trichiura Completed NCT02399683
14 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichuriasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: trichuriasis

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Genetic Tests for Trichuriasis

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Anatomical Context for Trichuriasis

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The Foundational Model of Anatomy Ontology organs/tissues related to Trichuriasis:

18
Intestine In Humans

MalaCards organs/tissues related to Trichuriasis:

38
Colon, T Cells
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Publications for Trichuriasis

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Articles related to Trichuriasis:

(show top 50) (show all 102)
# Title Authors Year
1
Trichuriasis. ( 29406051 )
2018
2
Clinical correlates of trichuriasis diagnosed at colonoscopy. ( 29058208 )
2017
3
A First Case of Human Trichuriasis from a Roman Lead Coffin in France. ( 27853119 )
2016
4
Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. ( 24515942 )
2014
5
Growth reduction among primary schoolchildren with light trichuriasis in Malaysia treated with albendazole. ( 23682433 )
2013
6
Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. ( 23523058 )
2013
7
Household social determinants of ascariasis and trichuriasis in North Central Venezuela. ( 24029148 )
2012
8
Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. ( 22041638 )
2012
9
Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. ( 21666788 )
2011
10
Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. ( 20700138 )
2010
11
Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis. ( 20687192 )
2010
12
Trichuriasis colitis detected by Doppler sonography. ( 20571789 )
2010
13
Sonographic whipworm dance in trichuriasis. ( 19321687 )
2009
14
Computed tomographic findings of trichuriasis. ( 16830393 )
2006
15
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. ( 16679166 )
2006
16
Immunity, immunoregulation and the ecology of trichuriasis and ascariasis. ( 15771679 )
2004
17
Prolonged treatment with albendazole for massive trichuriasis infection. ( 15545874 )
2004
18
Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. ( 15293971 )
2004
19
A case of gastroenteritis associated with gastric trichuriasis. ( 12808334 )
2003
20
Trichuriasis: localized inflammatory responses in the colon. ( 12236416 )
2002
21
Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. ( 12055813 )
2002
22
A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis. ( 11874563 )
2002
23
Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. ( 11865424 )
2002
24
Efficacy of multiple dose mebendazole against trichuriasis in Thai and Karen patients. ( 11289001 )
2000
25
Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. ( 11288999 )
2000
26
Use of Fenbendazole in Treating Trichuriasis in Colobus Monkeys. ( 23985619 )
1999
27
Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children. ( 9798586 )
1998
28
Ascariasis, trichuriasis, and growth of schoolchildren in Northeastern Peninsular Malaysia. ( 10772554 )
1998
29
Case in point. Trichuriasis. ( 7852465 )
1995
30
Trichuriasis associated to severe transient Coomb's-negative hemolytic anemia and macroscopic hematuria. ( 11995911 )
1995
31
Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model. ( 7974660 )
1994
32
Serum isotype responses after treatment of human trichuriasis. ( 7974688 )
1994
33
Does ascariasis, trichuriasis and hookworm infection predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8009635 )
1994
34
School performance, nutritional status and trichuriasis in Jamaican schoolchildren. ( 7531045 )
1994
35
Basal and ACTH-stimulated plasma aldosterone concentrations are normal or increased in dogs with trichuriasis-associated pseudohypoadrenocorticism. ( 7983625 )
1994
36
Transmission of trichuriasis in a sexual setting? ( 7849126 )
1994
37
Do ascariasis, trichuriasis and hookworm infections predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8273160 )
1993
38
A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. ( 7939948 )
1993
39
Modulation of cytokine production and response phenotypes in murine trichuriasis. ( 1437236 )
1992
40
Helper T-cell subsets in mouse trichuriasis. ( 15463401 )
1991
41
Ascariasis and trichuriasis in Cameroon. ( 2068772 )
1991
42
Host predisposition to trichuriasis: the mouse--T. muris model. ( 2762038 )
1989
43
Trichuris and trichuriasis in humans. ( 2683614 )
1989
44
The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. ( 3250338 )
1988
45
Gastric trichuriasis in a black and white colobus monkey. ( 3505990 )
1986
46
Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities. ( 3299888 )
1986
47
Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis. ( 4039128 )
1985
48
Benzimidazoles in the treatment of trichuriasis: a review. ( 6378109 )
1984
49
Selective primary health care: strategies for control of disease in the developing world. XII. Ascariasis and trichuriasis. ( 6377443 )
1984
50
Safety and efficacy of diphetarsone in the treatment of amoebiasis, non-pathogenic amoebiasis and trichuriasis. ( 6304952 )
1983
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Variations for Trichuriasis

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Expression for Trichuriasis

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Search GEO for disease gene expression data for Trichuriasis.
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Pathways for Trichuriasis

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Pathways related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 60
Show member pathways
 13.28 CXCL8 IL10 IL13 IL9 TNF
2
Akt Signaling 60
Show member pathways
 13.16 CXCL8 IL10 IL13 IL9 TNF
3
Cytokine Signaling in Immune system 62
Show member pathways
 13.11 CXCL8 IL10 IL13 IL9 TNF
4
PAK Pathway 60
Show member pathways
 13.05 CXCL8 IL10 IL13 IL9 TNF
5
Allograft rejection 1 36
Show member pathways
 12.63 CXCL8 IL10 IL13 IL9 TNF
6
Toll-like receptor signaling pathway 1 36
Show member pathways
 12.31 CXCL8 IL10 TNF
7
T cell receptor signaling pathway 36
Show member pathways
 12.23 IL10 IL9 TNF
8
Jak-STAT signaling pathway (KEGG) 36
Show member pathways
 12.16 IL10 IL13 IL9
9
IL-17 Family Signaling Pathways 61
Show member pathways
 12.13 CXCL8 IL13 TNF
10
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.97 CXCL8 IL10 IL13 TNF
11
Amoebiasis 36
11.73 CXCL8 IL10 TNF
12
Interleukin-4 and 13 signaling 62
11.68 CXCL8 IL10 IL13 TNF
13
Pertussis 36
11.61 CXCL8 IL10 TNF
14
Lung fibrosis 1
11.52 CXCL8 IL13 TNF
15
Innate Lymphoid Cell Differentiation Pathways 61
11.46 IL10 IL13 IL9 TNF
16
Malaria 36
11.4 CXCL8 IL10 TNF
17
Th2 Differentiation Pathway 61
11.36 IL10 IL13 IL9
18
Immune response IFN alpha/beta signaling pathway 21
Show member pathways
 11.23 CXCL8 IL10 IL13 IL9 TNF
19
African trypanosomiasis 36
11.2 IDO1 IL10 TNF
20
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
Show member pathways
 11.19 IL10 TNF
21
IL-10 Pathway 60
11.17 IL10 TNF
22
Development and heterogeneity of the ILC family 1
11.11 IL13 IL9 TNF
23
Cytokines and Inflammatory Response 1
11.06 IL10 IL13 TNF
24
EBV LMP1 signaling 1
10.99 CXCL8 TNF
25
OX40 Pathway 60
10.96 IL10 IL13 IL9
26
Interleukin-10 signaling 62
10.95 CXCL8 IL10 IL13 TNF
27
Overview of nanoparticle effects 1
10.87 CXCL8 TNF
28
G-protein signaling_Rap2B regulation pathway 21
10.81 CXCL8 IL10 IL13 IL9 TNF
29
G-protein signaling_RhoB regulation pathway 21
10.78 CXCL8 IL10 IL13 IL9 TNF
30
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
10.66 IL13 IL9
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GO Terms for Trichuriasis

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Cellular components related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CXCL8 IL10 IL13 IL9 TNF
2 extracellular region GO:0005576 9.1 CXCL8 IL10 IL13 IL9 PROK2 TNF

Biological processes related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.71 IDO1 IL10 IL13
2 cellular response to lipopolysaccharide GO:0071222 9.61 CXCL8 IL10 TNF
3 negative regulation of T cell proliferation GO:0042130 9.58 IDO1 IL10
4 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TNF
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.57 IL10 IL13
6 positive regulation of cytokine secretion GO:0050715 9.56 IL10 TNF
7 negative regulation of interleukin-6 production GO:0032715 9.55 IL10 TNF
8 immune response GO:0006955 9.55 CXCL8 IL10 IL13 IL9 TNF
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 IL10 TNF
10 embryonic digestive tract development GO:0048566 9.51 CXCL8 TNF
11 positive regulation of macrophage activation GO:0043032 9.49 IL10 IL13
12 negative regulation of growth of symbiont in host GO:0044130 9.48 IL10 TNF
13 response to molecule of bacterial origin GO:0002237 9.46 CXCL8 IL10
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
15 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
16 regulation of receptor activity GO:0010469 9.35 CXCL8 IL10 IL13 IL9 TNF
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
18 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
19 inflammatory response GO:0006954 9.17 CXCL8 IDO1 IL10 IL13 IL9 PROK2

Molecular functions related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL13 IL9 TNF
2 cytokine receptor binding GO:0005126 8.96 IL13 IL9
Sources

Sources for Trichuriasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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