MCID: TRC012
MIFTS: 45

Trichuriasis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Trichuriasis

Aliases & Descriptions for Trichuriasis:

Name: Trichuriasis 12 50 3 42 14
Whipworm Infection 50 3
Infection by Trichuris Trichiura 69
Infection by Trichuris Trichura 12
Trichuris Trichiura Infection 12
Trichuriasis Infection 12
Trichocephaliasis 50
Whipworm Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1252
ICD10 33 B79
ICD9CM 35 127.3
MeSH 42 D014257
UMLS 69 C0040954

Summaries for Trichuriasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

MalaCards based summary : Trichuriasis, also known as whipworm infection, is related to ascariasis and dahlberg borer newcomer syndrome, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is IL9 (Interleukin 9), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Piperazine and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and intestine in humans.

CDC : 3 An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide.

Wikipedia : 71 Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris... more...

Related Diseases for Trichuriasis

Diseases related to Trichuriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
id Related Disease Score Top Affiliating Genes
1 ascariasis 10.3
2 dahlberg borer newcomer syndrome 10.3 IL13 IL9
3 aortic atherosclerosis 10.3 IL13 TNF
4 papillary adenocarcinoma 10.2 IL10 IL13
5 duodenal somatostatinoma 10.2 IL13 IL9
6 goat milk allergy 10.2 IL10 IL13
7 indian plum allergy 10.2 IL10 IL13
8 myofibroma 10.2 IL10 IL13
9 pyridoxal 5'-phosphate-dependent epilepsy 10.2 IL10 TNF
10 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 TNF
11 lagophthalmos 10.2 IL10 TNF
12 multiple vertebral anomalies unusual facies 10.2 IL10 TNF
13 conidiobolomycosis 10.2 IL10 TNF
14 endosalpingiosis 10.2 IL10 TNF
15 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL10 TNF
16 idiopathic hypertrophic pachymeningitis 10.2 IL10 TNF
17 transient tic disorder 10.2 IL10 TNF
18 vestibule of mouth cancer 10.2 IL10 TNF
19 plantar wart 10.2 IL10 TNF
20 osteodysplasty precocious of danks mayne and kozlowski 10.2 IL10 TNF
21 parkinson disease 11 10.2 IL10 TNF
22 cyclosporiasis 10.2 IL10 TNF
23 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL10 TNF
24 congenital hypothyroidism 10.2 IL10 TNF
25 hemiplegia 10.2 IL10 IL13
26 sarcomatoid transitional cell carcinoma 10.2 IL10 TNF
27 neurotic disorder 10.2 IL10 TNF
28 trichomalacia 10.2 IL10 TNF
29 senile reticular retinal degeneration 10.2 IL10 TNF
30 conduct disorder 10.2 IL10 TNF
31 pancreatic signet ring cell adenocarcinoma 10.2 IL10 TNF
32 pulpitis 10.2 IL10 TNF
33 tularemia 10.2 IL10 TNF
34 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL10 TNF
35 pseudo-meigs syndrome 10.2 IL10 TNF
36 gonococcal endophthalmia 10.2 IL10 TNF
37 ectodermal dysplasia bartalos type 10.2 IL10 TNF
38 primary ciliary dyskinesia 10.2 IL10 TNF
39 cryptococcosis 10.2 IL10 TNF
40 hereditary alpha tryptasemia syndrome 10.2 IL10 TNF
41 hepatitis 10.2 IL10 TNF
42 rickettsialpox 10.2 IL10 TNF
43 autosomal recessive type iv ehlers-danlos syndrome 10.2 IL10 TNF
44 astrocytoma 10.2 IL10 TNF
45 bladder signet ring cell adenocarcinoma 10.1 IL10 TNF
46 acute myeloid leukemia with recurrent genetic anomaly 10.1 IL10 TNF
47 erb-duchenne and dejerine-klumpke palsies 10.1 IL10 TNF
48 microcephaly 10.1 IL10 TNF
49 abnormal retinal correspondence 10.1 IL10 TNF
50 plummer's disease 10.1 IL10 TNF

Graphical network of the top 20 diseases related to Trichuriasis:



Diseases related to Trichuriasis

Symptoms & Phenotypes for Trichuriasis

Symptoms:

12
  • abdominal pain
  • diarrhea
  • rectal prolapse
  • growth retardation

Drugs & Therapeutics for Trichuriasis

Drugs for Trichuriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Piperazine Approved, Vet_approved Phase 4,Phase 3 110-85-0 4837
2
Mebendazole Approved, Vet_approved Phase 4,Phase 3 31431-39-7 4030
3
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
4 Adjuvants, Immunologic Phase 4
5 Neuromuscular Agents Phase 4
6 Neuromuscular Blocking Agents Phase 4
7 Neuromuscular Depolarizing Agents Phase 4
8 Oxantel Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Anthelmintics Phase 4,Phase 3
11 Piperazine citrate Phase 4,Phase 3
12 Anti-Infective Agents Phase 4,Phase 3
13 Pyrantel Phase 4
14 Pyrantel Pamoate Phase 4
15 Antimitotic Agents Phase 4,Phase 3
16 Antirheumatic Agents Phase 4
17 Antiparasitic Agents Phase 4,Phase 3
18 Antiprotozoal Agents Phase 4
19 Citrate Nutraceutical Phase 4,Phase 3
20
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
21 Vaccines Phase 2
22 Pharmaceutical Solutions Phase 2
23 Cayenne Nutraceutical Phase 2
24
Ivermectin Approved, Vet_approved 70288-86-7 6474909 46936176
25
Praziquantel Approved, Vet_approved 55268-74-1 4891

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4
2 The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4
3 A Safety Study of Mebendazole in Children 2 to 10 Years of Age Completed NCT01173562 Phase 3
4 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
5 Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease Completed NCT01279577 Phase 2
6 TSO in Pediatric Autistic Spectrum Disorders Terminated NCT01734941 Phase 2
7 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
8 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753
9 Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression Completed NCT00507221
10 Immune Modulation From Trichuris Suis Completed NCT03079700
11 Immune Modulation From Trichuris Trichiura Completed NCT02399683
12 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichuriasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trichuriasis

Genetic Tests for Trichuriasis

Anatomical Context for Trichuriasis

MalaCards organs/tissues related to Trichuriasis:

39
Colon, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Trichuriasis:

18
Intestine In Humans

Publications for Trichuriasis

Articles related to Trichuriasis:

(show top 50) (show all 99)
id Title Authors Year
1
A First Case of Human Trichuriasis from a Roman Lead Coffin in France. ( 27853119 )
2016
2
Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. ( 24515942 )
2014
3
Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. ( 23523058 )
2013
4
Growth reduction among primary schoolchildren with light trichuriasis in Malaysia treated with albendazole. ( 23682433 )
2013
5
Household social determinants of ascariasis and trichuriasis in North Central Venezuela. ( 24029148 )
2012
6
Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. ( 22041638 )
2012
7
Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. ( 21666788 )
2011
8
Trichuriasis colitis detected by Doppler sonography. ( 20571789 )
2010
9
Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. ( 20700138 )
2010
10
Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis. ( 20687192 )
2010
11
Sonographic whipworm dance in trichuriasis. ( 19321687 )
2009
12
Computed tomographic findings of trichuriasis. ( 16830393 )
2006
13
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. ( 16679166 )
2006
14
Prolonged treatment with albendazole for massive trichuriasis infection. ( 15545874 )
2004
15
Immunity, immunoregulation and the ecology of trichuriasis and ascariasis. ( 15771679 )
2004
16
Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. ( 15293971 )
2004
17
A case of gastroenteritis associated with gastric trichuriasis. ( 12808334 )
2003
18
A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis. ( 11874563 )
2002
19
Trichuriasis: localized inflammatory responses in the colon. ( 12236416 )
2002
20
Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. ( 12055813 )
2002
21
Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. ( 11865424 )
2002
22
Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. ( 11288999 )
2000
23
Efficacy of multiple dose mebendazole against trichuriasis in Thai and Karen patients. ( 11289001 )
2000
24
Use of Fenbendazole in Treating Trichuriasis in Colobus Monkeys. ( 23985619 )
1999
25
Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children. ( 9798586 )
1998
26
Ascariasis, trichuriasis, and growth of schoolchildren in Northeastern Peninsular Malaysia. ( 10772554 )
1998
27
Case in point. Trichuriasis. ( 7852465 )
1995
28
Trichuriasis associated to severe transient Coomb's-negative hemolytic anemia and macroscopic hematuria. ( 11995911 )
1995
29
Does ascariasis, trichuriasis and hookworm infection predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8009635 )
1994
30
Transmission of trichuriasis in a sexual setting? ( 7849126 )
1994
31
Serum isotype responses after treatment of human trichuriasis. ( 7974688 )
1994
32
Basal and ACTH-stimulated plasma aldosterone concentrations are normal or increased in dogs with trichuriasis-associated pseudohypoadrenocorticism. ( 7983625 )
1994
33
Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model. ( 7974660 )
1994
34
School performance, nutritional status and trichuriasis in Jamaican schoolchildren. ( 7531045 )
1994
35
Do ascariasis, trichuriasis and hookworm infections predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8273160 )
1993
36
A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. ( 7939948 )
1993
37
Modulation of cytokine production and response phenotypes in murine trichuriasis. ( 1437236 )
1992
38
Ascariasis and trichuriasis in Cameroon. ( 2068772 )
1991
39
Helper T-cell subsets in mouse trichuriasis. ( 15463401 )
1991
40
Trichuris and trichuriasis in humans. ( 2683614 )
1989
41
Host predisposition to trichuriasis: the mouse--T. muris model. ( 2762038 )
1989
42
The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. ( 3250338 )
1988
43
Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities. ( 3299888 )
1986
44
Gastric trichuriasis in a black and white colobus monkey. ( 3505990 )
1986
45
Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis. ( 4039128 )
1985
46
Benzimidazoles in the treatment of trichuriasis: a review. ( 6378109 )
1984
47
Selective primary health care: strategies for control of disease in the developing world. XII. Ascariasis and trichuriasis. ( 6377443 )
1984
48
Safety and efficacy of diphetarsone in the treatment of amoebiasis, non-pathogenic amoebiasis and trichuriasis. ( 6304952 )
1983
49
Efficacy Of Mebendazole In Treatment And Control Of Trichuriasis In Korea. ( 12902674 )
1983
50
Cortisone-induced immunotolerance to nematode infection in CBA/Ca mice. II. A model for human chronic trichuriasis. ( 6826206 )
1983

Variations for Trichuriasis

Expression for Trichuriasis

Search GEO for disease gene expression data for Trichuriasis.

Pathways for Trichuriasis

Pathways related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 IL10 IL13 IL9 TNF
2 12.26 IDO1 IL10 TNF
3
Show member pathways
12.15 IL10 IL9 TNF
4
Show member pathways
11.95 IL10 IL13 IL9
5 11.91 IL10 IL13 TNF
6 11.71 IL10 IL13 TNF
7
Show member pathways
11.47 IL10 IL13 IL9 TNF
8 11.32 IL10 IL13 TNF
9 11.28 IL10 IL13 IL9
10 11.27 IL10 TNF
11
Show member pathways
11.17 IL10 TNF
12 11.09 IL10 TNF
13 11.09 IDO1 IL10 TNF
14 11 IL13 IL9 TNF
15 10.94 IL10 IL13 IL9 TNF
16 10.91 IL10 IL13 TNF
17 10.83 IL10 IL13 IL9 TNF
18 10.75 IL10 IL13 IL9
19 10.67 IL13 IL9

GO Terms for Trichuriasis

Biological processes related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 IL10 IL13 IL9 TNF
2 response to lipopolysaccharide GO:0032496 9.65 IDO1 IL10 IL13
3 negative regulation of T cell proliferation GO:0042130 9.55 IDO1 IL10
4 positive regulation of cytokine secretion GO:0050715 9.54 IL10 TNF
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 IL10 IL13
6 negative regulation of mitotic cell cycle GO:0045930 9.51 IL10 TNF
7 negative regulation of interleukin-6 production GO:0032715 9.49 IL10 TNF
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 IL10 TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 TNF
10 positive regulation of macrophage activation GO:0043032 9.37 IL10 IL13
11 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.32 IL10 TNF
12 endothelial cell apoptotic process GO:0072577 9.26 IL10 TNF
13 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 IL10 TNF
14 inflammatory response GO:0006954 9.1 IDO1 IL10 IL13 IL9 PROK2 TNF
15 receptor biosynthetic process GO:0032800 8.96 IL10 TNF

Molecular functions related to Trichuriasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL9
2 cytokine activity GO:0005125 8.92 IL10 IL13 IL9 TNF

Sources for Trichuriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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