MCID: TRC012
MIFTS: 45

Trichuriasis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Summaries for Trichuriasis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in trichuris trichiura, which is transmitted by ingestion of food contaminated with egg-carrying soil. the infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

MalaCards: Trichuriasis, also known as infection by trichuris trichiura, is related to ascariasis and helminthiasis, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is LILRA3 (leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3). The drugs albendazole and mebendazole and the compounds chloramphenicol and heme have been mentioned in the context of this disorder. Affiliated tissues include intestine in humans, colon and t cells.

CDC:4 An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide.

Wikipedia:66 Trichuriasis also known as whipworm infection is an infection by the parasitic worm Trichuris trichiura... more...

Aliases & Classifications for Trichuriasis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

trichuriasis 9 44 11
infection by trichuris trichiura 63
infection by trichuris trichura 9
trichuris trichiura infection 9
trichuriasis infection 9
whipworm infection 44
trichocephaliasis 44
whipworm disease 9


External Ids:

Disease Ontology9 DOID:1252
MeSH36 D014257
ICD9CM28 127.3
ICD1026 B79

Related Diseases for Trichuriasis

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18GeneCards, 19GeneDecks
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Diseases related to Trichuriasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1ascariasis10.7
2helminthiasis10.4
3atopy10.4
4strongyloidiasis10.1
5enterobiasis10.1
6ancylostomiasis10.1
7deficiency anemia10.0
8necatoriasis10.0
9rectal prolapse10.0
10iron deficiency anemia10.0
11yellow fever10.0
12scurvy10.0
13hymenolepiasis10.0
14tungiasis10.0
15typhoid fever10.0
16gastroenteritis10.0
17hemolytic anemia10.0
18malaria10.0
19ankylostomiasis10.0

Graphical network of diseases related to Trichuriasis:



Diseases related to trichuriasis

Symptoms for Trichuriasis

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9Disease Ontology
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Symptoms:

9
  • abdominal pain
  • diarrhea
  • rectal prolapse
  • growth retardation

Drugs & Therapeutics for Trichuriasis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Trichuriasis

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Anatomical Context for Trichuriasis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Trichuriasis:

34
Colon, T cells

FMA organs/tissues related to Trichuriasis:

15
Intestine in humans

Animal Models for Trichuriasis or affiliated genes

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Publications for Trichuriasis

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53PubMed
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Articles related to Trichuriasis:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Growth reduction among primary schoolchildren with light trichuriasis in Malaysia treated with albendazole. (23682433)
2013
2
Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. (23523058)
2013
3
Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. (22041638)
2012
4
Household social determinants of ascariasis and trichuriasis in North Central Venezuela. (24029148)
2012
5
Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. (21666788)
2011
6
Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. (20700138)
2010
7
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. (16679166)
2006
8
Computed tomographic findings of trichuriasis. (16830393)
2006
9
Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. (15293971)
2004
10
Trichuriasis: localized inflammatory responses in the colon. (12236416)
2002
11
Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. (11865424)
2002
12
Efficacy of multiple dose mebendazole against trichuriasis in Thai and Karen patients. (11289001)
2000
13
Use of Fenbendazole in Treating Trichuriasis in Colobus Monkeys. (23985619)
1999
14
Ascariasis, trichuriasis, and growth of schoolchildren in Northeastern Peninsular Malaysia. (10772554)
1998
15
Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model. (7974660)
1994
16
Ascariasis and trichuriasis in Cameroon. (2068772)
1991
17
Helper T-cell subsets in mouse trichuriasis. (15463401)
1991
18
Trichuris and trichuriasis in humans. (2683614)
1989
19
Host predisposition to trichuriasis: the mouse--T. muris model. (2762038)
1989
20
The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. (3250338)
1988
21
Gastric trichuriasis in a black and white colobus monkey. (3505990)
1986
22
Cortisone-induced immunotolerance to nematode infection in CBA/Ca mice. II. A model for human chronic trichuriasis. (6826206)
1983
23
Safety and efficacy of diphetarsone in the treatment of amoebiasis, non-pathogenic amoebiasis and trichuriasis. (6304952)
1983
24
Flubendazole and mebendazole in the treatment of trichuriasis and other helminthiases. (7332916)
1981
25
Evaluation of mebendazole in trichuriasis. (7228360)
1980
26
Trichuriasis. Roentgenographic features and differential diagnosis with lymphoid hyperplasia. (450490)
1979
27
Is trichuriasis associated with iron deficiency anemia? (464198)
1979
28
Further experience with mebendazole in the treatment of symptomatic trichuriasis in children. (646017)
1978
29
Mebendazole in the treatment of severe symptomatic trichuriasis in children. (848642)
1977
30
Pathophysiology of swine trichuriasis. (883715)
1977
31
Treatment for trichuriasis with oxantel. (1008134)
1976
32
Algorithms in the diagnosis and management of exotic diseases. IX. Trichuriasis. (1245771)
1976
33
Trichuriasis in Calcasieu Parish, Southwest Louisiana. (1185028)
1975
34
Treatment of trichuriasis with a new drug, mebendazole. (1113237)
1975
35
A clinical evaluation of the efficacy of mebendazole in the treatment of trichuriasis. (1098155)
1975
36
Mebendazole. Treatment of trichuriasis and ascariasis in Bahamian children. (4479643)
1974
37
Diphetarsone in trichuriasis. (4814638)
1974
38
Clinical trichuriasis produced experimentally in growing pigs. II. Anthelmintic efficacy of dichlorvos. (4519451)
1973
39
Prevalence of human ascariasis and trichuriasis in San Juan and vicinity, Puerto Rico. (4711667)
1973
40
Dichlorvos: an anthelmintic for primate trichuriasis. (4249649)
1970
41
Rectal prolapse in children with trichuriasis. (5980975)
1966
42
Trichuriasis. (5863191)
1965
43
THE THERAPY OF TRICHURIASIS WITH A COMBINATION OF THIABENDAZOLE AND PYRVINIUM PAMOATE. (14317649)
1965
44
STILBAZIUM IODIDE (MONOPAR) IN THE TREATMENT OF HUMAN TRICHURIASIS. (14336083)
1965
45
A TETRACHLORETHYLENE-CHENOPODIUM PREPARATION IN TRICHURIASIS. (14073709)
1963
46
Experimental trichuriasis. II. Anthelmintic screening against Trichuris muris in the albino mouse. (13752160)
1961
47
Experimental trichuriasis. I. Antagonism between Trichuris muris and Aspiculuris tetraptera in the albino mouse. (13752159)
1961
48
Effect of dithiazanine in ascariasis, trichuriasis, enterobiasis and ankylostomiasis. (13924257)
1961
49
Therapy of trichuriasis and ancylostomiasis with dithiazanine. (13698988)
1960
50
Treatment of trichuriasis with dithiazanine; a preliminary report. (13608089)
1959

Variations for Trichuriasis

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Expression for genes affiliated with Trichuriasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trichuriasis

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Pathways for genes affiliated with Trichuriasis

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Compounds for genes affiliated with Trichuriasis

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46Novoseek, 3BitterDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Trichuriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chloramphenicol46 3 52 1212.1HBE1, PI3
2heme30 25 1211.1HBE1, CYP4F3

GO Terms for genes affiliated with Trichuriasis

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17Gene Ontology
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Molecular functions related to Trichuriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1iron ion bindingGO:0055069.4HBE1, CYP4F3
2heme bindingGO:0200379.1HBE1, CYP4F3

Products for genes affiliated with Trichuriasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trichuriasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet