MCID: TRC062
MIFTS: 27

Tricuspid Atresia malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Tricuspid Atresia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Tricuspid atresia is a form of congenital heart disease whereby there is a complete absence of the... more...

MalaCards: Tricuspid Atresia, also known as congenital agenesis of the tricuspid valve, is related to tetralogy of fallot and ventricular septal defect. An important gene associated with Tricuspid Atresia is ZFPM2 (zinc finger protein, FOG family member 2), and among its related pathways is Platelet activation, signaling and aggregation. Affiliated tissues include heart, and related mouse phenotypes are homeostasis/metabolism and liver/biliary system.

Description from OMIM:46 605067

Aliases & Classifications for Tricuspid Atresia

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Sources:
42NIH Rare Diseases, 48Orphanet, 46OMIM, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
tricuspid atresia:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

tricuspid atresia 42 48 46
congenital agenesis of the tricuspid valve 42


External Ids:

SNOMED-CT via Orphanet57 253455004, 63042009
OMIM46 605067
MESH via Orphanet35 D018785
ICD10 via Orphanet26 Q22.4
UMLS via Orphanet61 C0243002

Related Diseases for Tricuspid Atresia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tricuspid Atresia:



Diseases related to tricuspid atresia

Clinical Features for Tricuspid Atresia

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46OMIM
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Clinical features from OMIM:

605067

Drugs & Therapeutics for Tricuspid Atresia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Tricuspid Atresia

Genetic Tests for Tricuspid Atresia

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Anatomical Context for Tricuspid Atresia

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32MalaCards
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MalaCards organs/tissues related to Tricuspid Atresia:

32
Heart

Animal Models for Tricuspid Atresia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tricuspid Atresia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.5ALB, ZFPM2, HEY2
2MP:00053708.2ALB, ZFPM2, HEY2

Publications for Tricuspid Atresia

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Genetic Variations for Tricuspid Atresia

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Expression for genes affiliated with Tricuspid Atresia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tricuspid Atresia

Search GEO for disease gene expression data for Tricuspid Atresia.

Pathways for genes affiliated with Tricuspid Atresia

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53Reactome
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Pathways related to Tricuspid Atresia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0ALB, ZFPM2

Compounds for genes affiliated with Tricuspid Atresia

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GO Terms for genes affiliated with Tricuspid Atresia

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Sources:
16Gene Ontology
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Biological processes related to Tricuspid Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ventricular septum morphogenesisGO:0604129.4HEY2, ZFPM2
2vasculogenesisGO:0015709.3ZFPM2, HEY2
3negative regulation of transcription from RNA polymerase II promoterGO:0001229.3HEY2, ZFPM2
4negative regulation of transcription, DNA-dependentGO:0458929.2HEY2, ZFPM2
5blood coagulationGO:0075968.7ZFPM2, ALB

Molecular functions related to Tricuspid Atresia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081349.3ZFPM2, HEY2

Products for genes affiliated with Tricuspid Atresia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tricuspid Atresia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet