MCID: TRC022
MIFTS: 36

Tricuspid Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Insufficiency

MalaCards integrated aliases for Tricuspid Valve Insufficiency:

Name: Tricuspid Valve Insufficiency 12 41 14 69
Tricuspid Regurgitation 12 28 51
Tricuspid Valve Regurgitation 12
Tricuspid Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4080
MeSH 41 D014262
UMLS 69 C0040961

Summaries for Tricuspid Valve Insufficiency

Disease Ontology : 12 A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary : Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to transposition of the great arteries and cardiac tamponade. An important gene associated with Tricuspid Valve Insufficiency is NPPB (Natriuretic Peptide B). The drugs Tolvaptan and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain.

Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 transposition of the great arteries 30.1 CRELD1 NPPB ZIC3
2 cardiac tamponade 10.4 ACVRL1 NPPB
3 toxic myocarditis 10.4 NPPB ZIC3
4 ebstein anomaly 10.4 CRELD1 NPPB
5 patent ductus arteriosus 1 10.3 CRELD1 NPPB
6 pericardial effusion 10.3 ACVRL1 NPPB
7 atrial heart septal defect 10.2 ACVRL1 CRELD1
8 aortic valve insufficiency 10.2 FBN1 NPPB
9 mitral valve stenosis 10.2 ACVRL1 CRELD1 NPPB
10 heart septal defect 10.2 ACVRL1 CRELD1
11 constrictive pericarditis 10.2 ALB NPPB
12 syndrome of inappropriate antidiuretic hormone 10.1 ALB NPPB
13 mitral valve insufficiency 10.1 CRELD1 FBN1 NPPB
14 aortic valve disease 1 10.1 CRELD1 FBN1 NPPB
15 renal hypertension 10.1 ALB NPPB
16 pulmonary valve insufficiency 10.0 BLVRA NPPB
17 tetralogy of fallot 10.0 CRELD1 FBN1 NPPB
18 arteries, anomalies of 10.0 ACVRL1 ALB NPPB
19 hydronephrosis 9.9 ALB ZIC3
20 endocardial fibroelastosis 9.9
21 hypoplastic left heart syndrome 1 9.9
22 myocardial infarction 9.9
23 infantile liver failure syndrome 1 9.9
24 pulmonary hypertension 9.9
25 acute liver failure 9.9
26 hypoplastic left heart syndrome 9.9
27 protein-losing enteropathy 9.9
28 inferior myocardial infarction 9.9
29 pulmonary valve stenosis 9.9
30 pulmonary atresia with intact ventricular septum 9.9
31 hemopericardium 9.9
32 tricuspid valve prolapse 9.9
33 mitral valve disease 9.9
34 congenitally corrected transposition of the great arteries 9.9
35 double discordia 9.9
36 tricuspid valve stenosis 9.7 ARSE CA6 CRELD1 FBN1
37 chromosomal disease 9.7 CRELD1 PAPPA
38 pneumothorax 9.6 BLVRA FBN1
39 heart disease 9.4 ALB CRELD1 FBN1 NPPB ZIC3
40 tricuspid valve disease 9.2 ACVRL1 ARSE CRELD1 FBN1 MC3R NPPB

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:



Diseases related to Tricuspid Valve Insufficiency

Symptoms & Phenotypes for Tricuspid Valve Insufficiency

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 4 150683-30-0 216237
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
3 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
4 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2
5 Phosphodiesterase Inhibitors Phase 4,Phase 2
6 Sildenafil Citrate Phase 4,Phase 2 171599-83-0
7 Vasodilator Agents Phase 4,Phase 2
8 Antihypertensive Agents Phase 4,Phase 2
9 Arginine Vasopressin Phase 4
10 diuretics Phase 4
11 Hormones Phase 4
12 Natriuretic Agents Phase 4
13 Sodium Potassium Chloride Symporter Inhibitors Phase 4
14 Torsemide Phase 4
15 Vasopressins Phase 4
16 Anticoagulants Phase 4
17 Calcium, Dietary Phase 4
18 Chelating Agents Phase 4
19 Citrate Nutraceutical Phase 4,Phase 2
20
Bupivacaine Approved, Investigational Phase 3 38396-39-3, 2180-92-9 2474
21 Anesthetics Phase 3
22 Central Nervous System Depressants Phase 3
23 Peripheral Nervous System Agents Phase 3,Phase 2
24 Anesthetics, Local Phase 3
25 Pharmaceutical Solutions Phase 3
26
Angiotensin II Approved, Investigational Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
27
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
28
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
29
Adenosine Approved, Investigational Phase 1, Phase 2 58-61-7 60961
30
Regadenoson Approved, Investigational Phase 1, Phase 2 313348-27-5 219024
31
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
32 Angiotensin II Type 1 Receptor Blockers Phase 2
33 Angiotensin Receptor Antagonists Phase 2
34 Angiotensinogen Phase 2
35 LCZ 696 Phase 2
36 Antidotes Phase 2
37 Anti-Infective Agents Phase 2
38 Antioxidants Phase 2
39 Antiviral Agents Phase 2
40 Expectorants Phase 2
41 N-monoacetylcystine Phase 2
42 Protective Agents Phase 2
43 Respiratory System Agents Phase 2
44 Fibrinolytic Agents Phase 2
45 Plasminogen Phase 2
46 Saruplase Phase 2
47 Tissue Plasminogen Activator Phase 2
48 Analgesics Phase 2
49 Analgesics, Non-Narcotic Phase 2
50 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 77)

# Name Status NCT ID Phase Drugs
1 Tricuspid Regurgitation Study Completed NCT01093001 Phase 4
2 The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement Completed NCT02644616 Phase 4 tolvaptan+torasemide;placebo+torasemide
3 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease Completed NCT00862043 Phase 4 Sildenafil Citrate;Placebo
4 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
5 Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension Active, not recruiting NCT01642407 Phase 4 Sildenafil
6 BOOST - Benefit of Frequent Optimization After Cardiac Resynchronization Therapy Device Replacement Terminated NCT00929474 Phase 4
7 Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network Completed NCT00115934 Phase 3
8 Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride Not yet recruiting NCT03270514 Phase 3 Exparel Injectable Product;Bupivacaine Hydrochloride
9 LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction Completed NCT00887588 Phase 2 LCZ696;Valsartan;Placebo
10 NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients Completed NCT00809094 Phase 2 N-acetylcysteine (NAC);Placebo
11 Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System Recruiting NCT03331380 Phase 1, Phase 2
12 A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism Recruiting NCT03108833 Phase 2 Recombinant Human Prourokinase;Alteplase
13 Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension Recruiting NCT02951429 Phase 2 Pirfenidone;Placebo;Sildenafil
14 Effects of GSK1278863A on Pulmonary Artery Pressure in Healthy Volunteers Completed NCT01673555 Phase 1 GSK1278863;Placebo
15 Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome Recruiting NCT02398604 Phase 1 Allo-hMSCs;Placebo
16 Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™ Active, not recruiting NCT02098200 Phase 1
17 Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome: An Open Label Pilot Study. Not yet recruiting NCT03406884 Phase 1 c-kit+ cells;Placebo
18 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
19 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
20 Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL) Unknown status NCT02387697
21 Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery Unknown status NCT01580436
22 The Impact of Right Ventricular Pacing on Tricuspid Regurgitation Unknown status NCT00419354
23 Long-term Outcome After Isolated Tricuspid Valve Repair Unknown status NCT01537458
24 Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients Unknown status NCT00772135 sildenafil citrate
25 Is There a Correlation Between the Pulmonary Artery Pressure and the Acceleration of the Flow in the Pulmonary Artery Evaluated by Transesophageal Echocardiography (TOE) ? Unknown status NCT01947257
26 Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease Unknown status NCT00434902
27 Changes in the Tricuspid Valve Complex Induced by Mitral Valve Annuloplasty Unknown status NCT02357862
28 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Completed NCT01246947
29 Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation Completed NCT01203137
30 The Comparison of Tricuspid Replacement and Repair in Patients With Combined Heart Valve Disease Completed NCT01246141
31 EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty Completed NCT01532921
32 Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial Completed NCT01585779
33 Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients Completed NCT01023451
34 Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery Completed NCT02831270 hydroxyethyl starch (HES 130/0.6)
35 Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery Completed NCT02502448 hydroxyethyl starch (HES 130/0.6)
36 Long Term Effects of Erythrocyte Lysis Completed NCT00842621
37 Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 Completed NCT00665301
38 IMAGE: A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant Rejection Completed NCT00351559
39 Coenzyme Q-10 and Pulmonary Arterial Hypertension Completed NCT01148836
40 Sleep Apnea Intervention for Cardiovascular Disease Reduction Completed NCT01261390
41 REVADE : Right Ventricular Function and Exercise in Left Ventricular Assist Device Patients : Echocardiographic Study Completed NCT02067455
42 Neonatal Resuscitation With Intact Cord Completed NCT02231411
43 Pulmonary Arteriopathy-Diagnostics and Therapy Completed NCT00266175
44 Evaluation of Treatment With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater Tricuspid Regurgitation (TRILUMINATE) Recruiting NCT03227757
45 Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation Recruiting NCT03159923
46 Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency Recruiting NCT03144024
47 Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients Recruiting NCT02537769
48 Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Recruiting NCT03225612
49 Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation Recruiting NCT01502462
50 Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™. Recruiting NCT02574650

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

# Genetic test Affiliating Genes
1 Tricuspid Regurgitation 28

Anatomical Context for Tricuspid Valve Insufficiency

MalaCards organs/tissues related to Tricuspid Valve Insufficiency:

38
Heart, Liver, Brain, Testes, Lung

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show all 22)
# Title Authors Year
1
A systematic method for using 3D echocardiography to evaluate tricuspid valve insufficiency in hypoplastic left heart syndrome. ( 25298694 )
2014
2
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? ( 21801319 )
2012
3
Surgical treatment of tricuspid valve insufficiency promotes early reverse remodeling in patients with axial-flow left ventricular assist devices. ( 21839483 )
2012
4
Pulmonary arterial pressure and right ventricular dilatation independently determine tricuspid valve insufficiency severity in pre-capillary pulmonary hypertension. ( 23409355 )
2012
5
The clover technique for the treatment of complex tricuspid valve insufficiency: midterm clinical and echocardiographic results in 66 patients. ( 20117940 )
2010
6
Retrospective analysis of stage I Norwood procedures with tricuspid valve insufficiency in the past 5 years. ( 17669787 )
2007
7
Cardiac bullet embolus after thoracic vena cava penetrating injury causing tricuspid valve insufficiency. ( 17386917 )
2007
8
Acute liver failure as the first manifestation of severe traumatic tricuspid valve insufficiency. ( 16432673 )
2006
9
Diagnosis and treatment of traumatic tricuspid valve insufficiency. ( 14642061 )
2003
10
Traumatic tricuspid valve insufficiency: case report. ( 11499605 )
2001
11
Post-traumatic tricuspid valve insufficiency. 2 cases of delayed clinical manifestation. ( 9339514 )
1997
12
Repair of traumatic tricuspid valve insufficiency by trabecular muscle elevation. ( 7887723 )
1995
13
Fetal and transient neonatal right heart dilatation with severe tricuspid valve insufficiency in association with abnormally S-shaped kinking of the ductus arteriosus. ( 7614140 )
1995
14
Traumatic tricuspid valve insufficiency. Experience in thirteen patients. ( 7967672 )
1994
15
Tricuspid valve insufficiency as a complication of endomyocardial biopsy. ( 14621794 )
1992
16
Endocardial fibroelastosis and tricuspid valve insufficiency in a calf. ( 3610756 )
1987
17
Repair of tricuspid valve insufficiency in patients undergoing double (aortic and mitral) valve replacement. Perioperative mortality and long-term (1 to 20 years) follow-up in 109 patients. ( 3669702 )
1987
18
Transient tricuspid valve insufficiency following acute inferior myocardial infarction. ( 3485873 )
1986
19
"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency. ( 519671 )
1979
20
Management of tricuspid valve insufficiency. Replacement with Hancock bioprosthesis or suture annuloplasty. ( 511908 )
1979
21
Dynamic tricuspid valve insufficiency produced by a right ventricular thrombus from a pacemaker. ( 699661 )
1978
22
An interventricular septal defect and a tricuspid valve insufficiency in a trotter mare. ( 4426317 )
1974

Variations for Tricuspid Valve Insufficiency

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

Pathways for Tricuspid Valve Insufficiency

GO Terms for Tricuspid Valve Insufficiency

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 ALB FBN1 PAPPA
2 regulation of blood pressure GO:0008217 8.8 ACVRL1 MC3R NPPB

Molecular functions related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.23 ACVRL1 ALB ARSE BLVRA CA6 PAPPA

Sources for Tricuspid Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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