MCID: TRC022
MIFTS: 34

Tricuspid Valve Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Insufficiency

MalaCards integrated aliases for Tricuspid Valve Insufficiency:

Name: Tricuspid Valve Insufficiency 12 42 14 69
Tricuspid Regurgitation 12 29 52
Tricuspid Valve Regurgitation 12
Tricuspid Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4080
MeSH 42 D014262
UMLS 69 C0040961

Summaries for Tricuspid Valve Insufficiency

Disease Ontology : 12 A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary : Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to ophthalmia neonatorum and autonomic neuropathy. An important gene associated with Tricuspid Valve Insufficiency is NPPB (Natriuretic Peptide B). The drugs Tolvaptan and Phosphodiesterase 5 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain.

Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 ophthalmia neonatorum 10.6 NPPB ZIC3
2 autonomic neuropathy 10.5 ACVRL1 NPPB
3 congenital diarrhea 7 with exudative enteropathy 10.5 NPPB ZIC3
4 macroglossia 10.5 CRELD1 NPPB
5 pleomorphic liposarcoma 10.4 FBN1 NPPB
6 american histoplasmosis 10.3 ACVRL1 CRELD1 NPPB
7 urinary bladder posterior wall cancer 10.3 ACVRL1 NPPB
8 idiopathic peripheral autonomic neuropathy 10.3 ALB NPPB
9 optic nerve disease 10.3 ACVRL1 CRELD1
10 herpangina 10.3 CA6 NPPB
11 congenital nonspherocytic hemolytic anemia 10.3 ALB NPPB
12 tricho odonto onycho dermal syndrome 10.3 CRELD1 NPPB ZIC3
13 synovial chondromatosis 10.2 ALB NPPB
14 suppurative otitis media 10.2 CRELD1 FBN1 NPPB
15 adams-oliver syndrome 5 10.2 CRELD1 FBN1 NPPB
16 ichthyosis 10.1 ACVRL1 CRELD1
17 pyrimidine metabolic disorder 10.1 ACVRL1 ALB
18 broad ligament malignant neoplasm 10.1 ALB NPPB
19 hypothyroidism, congenital nongoitrous, 5 10.1 CRELD1 FBN1 NPPB
20 dysbaric osteonecrosis 10.0 CRELD1 PAPPA
21 myocardial infarction 9.8
22 endocardial fibroelastosis 9.8
23 pulmonary hypertension 9.8
24 acute liver failure 9.8
25 hypoplastic left heart syndrome 9.8
26 protein-losing enteropathy 9.8
27 inferior myocardial infarction 9.8
28 pulmonary valve stenosis 9.8
29 pulmonary atresia with intact ventricular septum 9.8
30 hemopericardium 9.8
31 tricuspid valve prolapse 9.8
32 mitral valve disease 9.8
33 congenitally corrected transposition of the great arteries 9.8
34 transposition of the great arteries 9.8
35 pulpitis 9.6 ALB ZIC3
36 artery disease 9.3 ACVRL1 CRELD1 FBN1 MC3R NPPB ZIC3
37 xanthogranulomatous pyelonephritis 9.2 ALB CRELD1 FBN1 NPPB ZIC3
38 trophoblastic neoplasm 9.1 ARSE CA6 CRELD1 FBN1
39 testicular germ cell tumor non-seminomatous 5.9 ACVRL1 ALB ARSE CA6 CRELD1 FBN1

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:



Diseases related to Tricuspid Valve Insufficiency

Symptoms & Phenotypes for Tricuspid Valve Insufficiency

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 4 150683-30-0 216237
2 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2
3 Phosphodiesterase Inhibitors Phase 4,Phase 2
4 Sildenafil Citrate Phase 4,Phase 2 171599-83-0
5 Vasodilator Agents Phase 4,Phase 2
6 Antihypertensive Agents Phase 4,Phase 2
7 Arginine Vasopressin Phase 4
8 diuretics Phase 4
9 Hormones Phase 4
10 Natriuretic Agents Phase 4
11 Sodium Potassium Chloride Symporter Inhibitors Phase 4
12 Torsemide Phase 4
13 Vasopressins Phase 4
14 Anticoagulants Phase 4
15 Calcium, Dietary Phase 4
16 Chelating Agents Phase 4
17 Citrate Nutraceutical Phase 4,Phase 2
18
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 2 77-92-9 311
19 Kava Nutraceutical Phase 4 9000-38-8
20 Calamus Nutraceutical Phase 4
21
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
22 Anesthetics Phase 3
23 Central Nervous System Depressants Phase 3
24 Peripheral Nervous System Agents Phase 3,Phase 2
25 Anesthetics, Local Phase 3
26 Pharmaceutical Solutions Phase 3
27
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
28
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
29
Angiotensin II Investigational Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
30
Pirfenidone Investigational Phase 2 53179-13-8 40632
31 Angiotensin II Type 1 Receptor Blockers Phase 2
32 Angiotensin Receptor Antagonists Phase 2
33 Angiotensinogen Phase 2
34 LCZ 696 Phase 2
35 Antidotes Phase 2
36 Anti-Infective Agents Phase 2
37 Antioxidants Phase 2
38 Antiviral Agents Phase 2
39 Expectorants Phase 2
40 N-monoacetylcystine Phase 2
41 Protective Agents Phase 2
42 Respiratory System Agents Phase 2
43 Fibrinolytic Agents Phase 2
44 Plasminogen Phase 2
45 Saruplase Phase 2
46 Tissue Plasminogen Activator Phase 2
47 Analgesics Phase 2
48 Analgesics, Non-Narcotic Phase 2
49 Anti-Inflammatory Agents Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:

(show top 50) (show all 75)

id Name Status NCT ID Phase Drugs
1 Tricuspid Regurgitation Study Completed NCT01093001 Phase 4
2 The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement Completed NCT02644616 Phase 4 tolvaptan+torasemide;placebo+torasemide
3 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease Completed NCT00862043 Phase 4 Sildenafil Citrate;Placebo
4 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
5 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
6 BOOST - Benefit of Frequent Optimization After Cardiac Resynchronization Therapy Device Replacement Terminated NCT00929474 Phase 4
7 Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network Completed NCT00115934 Phase 3
8 Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride Not yet recruiting NCT03270514 Phase 3 Exparel Injectable Product;Bupivacaine Hydrochloride
9 LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction Completed NCT00887588 Phase 2 LCZ696;Valsartan;Placebo
10 NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients Completed NCT00809094 Phase 2 N-acetylcysteine (NAC);Placebo
11 A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism Recruiting NCT03108833 Phase 2 Recombinant Human Prourokinase;Alteplase
12 Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension Recruiting NCT02951429 Phase 2 Pirfenidone;Placebo;Sildenafil
13 Effects of GSK1278863A on Pulmonary Artery Pressure in Healthy Volunteers Completed NCT01673555 Phase 1 GSK1278863;Placebo
14 Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome Recruiting NCT02398604 Phase 1 Allo-hMSCs;Placebo
15 Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™ Active, not recruiting NCT02098200 Phase 1
16 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
17 Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL) Unknown status NCT02387697
18 The Impact of Right Ventricular Pacing on Tricuspid Regurgitation Unknown status NCT00419354
19 Long-term Outcome After Isolated Tricuspid Valve Repair Unknown status NCT01537458
20 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Unknown status NCT02314897
21 Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients Unknown status NCT00772135 sildenafil citrate
22 Is There a Correlation Between the Pulmonary Artery Pressure and the Acceleration of the Flow in the Pulmonary Artery Evaluated by Transesophageal Echocardiography (TOE) ? Unknown status NCT01947257
23 Changes in the Tricuspid Valve Complex Induced by Mitral Valve Annuloplasty Unknown status NCT02357862
24 Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease Unknown status NCT00434902
25 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Completed NCT01246947
26 Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation Completed NCT01203137
27 The Comparison of Tricuspid Replacement and Repair in Patients With Combined Heart Valve Disease Completed NCT01246141
28 EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty Completed NCT01532921
29 Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial Completed NCT01585779
30 Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients Completed NCT01023451
31 Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery Completed NCT02831270 hydroxyethyl starch (HES 130/0.6)
32 Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery Completed NCT02502448 hydroxyethyl starch (HES 130/0.6)
33 Long Term Effects of Erythrocyte Lysis Completed NCT00842621
34 Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 Completed NCT00665301
35 IMAGE: A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant Rejection Completed NCT00351559
36 Coenzyme Q-10 and Pulmonary Arterial Hypertension Completed NCT01148836
37 Sleep Apnea Intervention for Cardiovascular Disease Reduction Completed NCT01261390
38 REVADE : Right Ventricular Function and Exercise in Left Ventricular Assist Device Patients : Echocardiographic Study Completed NCT02067455
39 Pulmonary Arteriopathy-Diagnostics and Therapy Completed NCT00266175
40 Neonatal Resuscitation With Intact Cord Completed NCT02231411
41 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
42 Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation Recruiting NCT03159923
43 Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency Recruiting NCT03144024
44 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Recruiting NCT02721524
45 The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System Recruiting NCT02787408
46 Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery Recruiting NCT01580436
47 Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients Recruiting NCT02537769
48 Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Recruiting NCT03225612
49 Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™. Recruiting NCT02574650
50 Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation Recruiting NCT01502462

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

id Genetic test Affiliating Genes
1 Tricuspid Regurgitation 29

Anatomical Context for Tricuspid Valve Insufficiency

MalaCards organs/tissues related to Tricuspid Valve Insufficiency:

39
Heart, Liver, Brain, Testes, Lung

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show all 22)
id Title Authors Year
1
A systematic method for using 3D echocardiography to evaluate tricuspid valve insufficiency in hypoplastic left heart syndrome. ( 25298694 )
2014
2
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? ( 21801319 )
2012
3
Pulmonary arterial pressure and right ventricular dilatation independently determine tricuspid valve insufficiency severity in pre-capillary pulmonary hypertension. ( 23409355 )
2012
4
Surgical treatment of tricuspid valve insufficiency promotes early reverse remodeling in patients with axial-flow left ventricular assist devices. ( 21839483 )
2012
5
The clover technique for the treatment of complex tricuspid valve insufficiency: midterm clinical and echocardiographic results in 66 patients. ( 20117940 )
2010
6
Cardiac bullet embolus after thoracic vena cava penetrating injury causing tricuspid valve insufficiency. ( 17386917 )
2007
7
Retrospective analysis of stage I Norwood procedures with tricuspid valve insufficiency in the past 5 years. ( 17669787 )
2007
8
Acute liver failure as the first manifestation of severe traumatic tricuspid valve insufficiency. ( 16432673 )
2006
9
Diagnosis and treatment of traumatic tricuspid valve insufficiency. ( 14642061 )
2003
10
Traumatic tricuspid valve insufficiency: case report. ( 11499605 )
2001
11
Post-traumatic tricuspid valve insufficiency. 2 cases of delayed clinical manifestation. ( 9339514 )
1997
12
Fetal and transient neonatal right heart dilatation with severe tricuspid valve insufficiency in association with abnormally S-shaped kinking of the ductus arteriosus. ( 7614140 )
1995
13
Repair of traumatic tricuspid valve insufficiency by trabecular muscle elevation. ( 7887723 )
1995
14
Traumatic tricuspid valve insufficiency. Experience in thirteen patients. ( 7967672 )
1994
15
Tricuspid valve insufficiency as a complication of endomyocardial biopsy. ( 14621794 )
1992
16
Repair of tricuspid valve insufficiency in patients undergoing double (aortic and mitral) valve replacement. Perioperative mortality and long-term (1 to 20 years) follow-up in 109 patients. ( 3669702 )
1987
17
Endocardial fibroelastosis and tricuspid valve insufficiency in a calf. ( 3610756 )
1987
18
Transient tricuspid valve insufficiency following acute inferior myocardial infarction. ( 3485873 )
1986
19
Management of tricuspid valve insufficiency. Replacement with Hancock bioprosthesis or suture annuloplasty. ( 511908 )
1979
20
"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency. ( 519671 )
1979
21
Dynamic tricuspid valve insufficiency produced by a right ventricular thrombus from a pacemaker. ( 699661 )
1978
22
An interventricular septal defect and a tricuspid valve insufficiency in a trotter mare. ( 4426317 )
1974

Variations for Tricuspid Valve Insufficiency

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

Pathways for Tricuspid Valve Insufficiency

GO Terms for Tricuspid Valve Insufficiency

Cellular components related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.8 ALB ARSE FBN1

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 ALB FBN1 PAPPA
2 regulation of blood pressure GO:0008217 8.8 ACVRL1 MC3R NPPB

Sources for Tricuspid Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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