MCID: TRC022
MIFTS: 33

Tricuspid Valve Insufficiency malady

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Insufficiency

Aliases & Descriptions for Tricuspid Valve Insufficiency:

Name: Tricuspid Valve Insufficiency 12 42 14 69
Tricuspid Regurgitation 12 29 52 14
Tricuspid Valve Regurgitation 12
Tricuspid Incompetence 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4080
MeSH 42 D014262
UMLS 69 C0040961

Summaries for Tricuspid Valve Insufficiency

Disease Ontology : 12 A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary : Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to autonomic neuropathy and macroglossia. An important gene associated with Tricuspid Valve Insufficiency is NPPB (Natriuretic Peptide B). The drugs Tolvaptan and Phosphodiesterase 5 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart and liver.

Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 autonomic neuropathy 10.3 ACVRL1 NPPB
2 macroglossia 10.2 CRELD1 NPPB
3 vitreous disease 10.2 NPPB ZIC3
4 american histoplasmosis 10.2 CRELD1 NPPB
5 stiff skin syndrome 10.2 ACVRL1 FBN1
6 idiopathic peripheral autonomic neuropathy 10.2 ALB NPPB
7 glucosephosphate dehydrogenase deficiency 10.2 ALB NPPB
8 chronic fatigue syndrome 10.2 NPPB PDZK1IP1
9 median neuropathy 10.2 FBN1 NPPB
10 sezary's disease 10.2 NPPB PDZK1IP1
11 syringomelia hyperkeratosis 10.1 ALB NPPB
12 ascending cholangitis 10.1 BLVRA NPPB
13 trichodental syndrome 10.1 CRELD1 ZIC3
14 optic nerve disease 10.1 ACVRL1 CRELD1
15 suppurative otitis media 10.1 CRELD1 FBN1 NPPB
16 generalized dystonia 10.1 ACVRL1 ALB
17 petrositis 10.1 ALB NPPB
18 cerebral convexity meningioma 10.1 CRELD1 FBN1 NPPB
19 ceroid lipofuscinosis, neuronal, 8 10.0 CRELD1 FBN1 NPPB
20 testicular germ cell tumor non-seminomatous 10.0 CRELD1 FBN1
21 urinary bladder posterior wall cancer 10.0 ACVRL1 NPPB
22 cystitis 10.0 BLVRA FBN1
23 myocardial infarction 9.8
24 endocardial fibroelastosis 9.8
25 pulmonary hypertension 9.8
26 acute liver failure 9.8
27 hypoplastic left heart syndrome 9.8
28 protein-losing enteropathy 9.8
29 inferior myocardial infarction 9.8
30 pulmonary valve stenosis 9.8
31 pulmonary atresia with intact ventricular septum 9.8
32 hemopericardium 9.8
33 tricuspid valve prolapse 9.8
34 mitral valve disease 9.8
35 congenitally corrected transposition of the great arteries 9.8
36 transposition of the great arteries 9.8
37 pericardium disease 9.5 ACVRL1 CRELD1 FBN1 MC3R NPPB PDZK1IP1
38 testicular pure germ cell tumor 8.5 ACVRL1 ALB BLVRA CRELD1 FBN1 MC3R

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:



Diseases related to Tricuspid Valve Insufficiency

Symptoms & Phenotypes for Tricuspid Valve Insufficiency

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tolvaptan Approved Phase 4 150683-30-0 216237
2 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
3 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
4 Sildenafil Citrate Phase 4,Phase 3,Phase 2 171599-83-0
5 Vasodilator Agents Phase 4,Phase 3,Phase 2
6 Antihypertensive Agents Phase 4,Phase 2
7 Arginine Vasopressin Phase 4
8 diuretics Phase 4
9 Hormones Phase 4
10 Natriuretic Agents Phase 4
11 Sodium Potassium Chloride Symporter Inhibitors Phase 4
12 Torsemide Phase 4
13 Vasopressins Phase 4
14 Anticoagulants Phase 4
15 Calcium, Dietary Phase 4
16 Chelating Agents Phase 4
17 Citrate Nutraceutical Phase 4,Phase 3,Phase 2
18
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
19 Kava Nutraceutical Phase 4 9000-38-8
20 Calamus Nutraceutical Phase 4
21
Valsartan Approved, Investigational Phase 2 137862-53-4 60846
22
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
23
Pirfenidone Investigational Phase 2 53179-13-8 40632
24
Angiotensin II Phase 2 68521-88-0, 11128-99-7 65143 172198
25 Angiotensin II Type 1 Receptor Blockers Phase 2
26 Angiotensin Receptor Antagonists Phase 2
27 Angiotensinogen Phase 2
28 LCZ 696 Phase 2
29 Antidotes Phase 2
30 Anti-Infective Agents Phase 2
31 Antioxidants Phase 2
32 Antiviral Agents Phase 2
33 Expectorants Phase 2
34 N-monoacetylcystine Phase 2
35 Protective Agents Phase 2
36 Respiratory System Agents Phase 2
37 Fibrinolytic Agents Phase 2
38 Plasminogen Phase 2
39 Saruplase Phase 2
40 Tissue Plasminogen Activator Phase 2
41 Analgesics Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Anti-Inflammatory Agents Phase 2
44 Anti-Inflammatory Agents, Non-Steroidal Phase 2
45 Antirheumatic Agents Phase 2
46 Peripheral Nervous System Agents Phase 2
47
Glycine Approved, Nutraceutical, Vet_approved Phase 1 56-40-6 750
48 Neurotransmitter Agents Phase 1
49
Hydroxyurea Approved 127-07-1 3657
50
Ethanol Approved 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 72)
id Name Status NCT ID Phase
1 Tricuspid Regurgitation Study Completed NCT01093001 Phase 4
2 The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement Completed NCT02644616 Phase 4
3 Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease Completed NCT00862043 Phase 4
4 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
5 Heterotopic Implantation Of the Edwards-Sapien XT Transcatheter Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) Recruiting NCT02339974 Phase 4
6 BOOST - Benefit of Frequent Optimization After Cardiac Resynchronization Therapy Device Replacement Terminated NCT00929474 Phase 4
7 Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network Completed NCT00115934 Phase 3
8 Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension Active, not recruiting NCT01642407 Phase 3
9 LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction Completed NCT00887588 Phase 2
10 NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients Completed NCT00809094 Phase 2
11 A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism Recruiting NCT03108833 Phase 2
12 Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension Recruiting NCT02951429 Phase 2
13 Effects of GSK1278863A on Pulmonary Artery Pressure in Healthy Volunteers Completed NCT01673555 Phase 1
14 Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™ Recruiting NCT02098200 Phase 1
15 Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome Recruiting NCT02398604 Phase 1
16 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
17 Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation Unknown status NCT01246947
18 Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL) Unknown status NCT02387697
19 The Impact of Right Ventricular Pacing on Tricuspid Regurgitation Unknown status NCT00419354
20 Long-term Outcome After Isolated Tricuspid Valve Repair Unknown status NCT01537458
21 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Unknown status NCT02314897
22 Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients Unknown status NCT00772135
23 Is There a Correlation Between the Pulmonary Artery Pressure and the Acceleration of the Flow in the Pulmonary Artery Evaluated by Transesophageal Echocardiography (TOE) ? Unknown status NCT01947257
24 Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease Unknown status NCT00434902
25 Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation Completed NCT01203137
26 The Comparison of Tricuspid Replacement and Repair in Patients With Combined Heart Valve Disease Completed NCT01246141
27 EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty Completed NCT01532921
28 Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial Completed NCT01585779
29 Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients Completed NCT01023451
30 Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery Completed NCT02831270
31 Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery Completed NCT02502448
32 Long Term Effects of Erythrocyte Lysis Completed NCT00842621
33 Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000 Completed NCT00665301
34 IMAGE: A Comparison of AlloMap Molecular Testing and Traditional Biopsy-based Surveillance for Heart Transplant Rejection Completed NCT00351559
35 Coenzyme Q-10 and Pulmonary Arterial Hypertension Completed NCT01148836
36 Sleep Apnea Intervention for Cardiovascular Disease Reduction Completed NCT01261390
37 REVADE : Right Ventricular Function and Exercise in Left Ventricular Assist Device Patients : Echocardiographic Study Completed NCT02067455
38 Pulmonary Arteriopathy-Diagnostics and Therapy Completed NCT00266175
39 Neonatal Resuscitation With Intact Cord Completed NCT02231411
40 Perioperative Changes of Cognitive Function According to Jugular Vein Insufficiency in Robot-assisted Prostatectomy Completed NCT01905488
41 ACCESS-Europe A Two-Phase Observational Study of the MitraClip® System in Europe Completed NCT01288976
42 Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation Recruiting NCT03159923
43 Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency Recruiting NCT03144024
44 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Recruiting NCT02721524
45 The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System Recruiting NCT02787408
46 Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery Recruiting NCT01580436
47 Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients Recruiting NCT02537769
48 Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™. Recruiting NCT02574650
49 Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation Recruiting NCT01502462
50 TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System Recruiting NCT02981953

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

id Genetic test Affiliating Genes
1 Tricuspid Regurgitation 29

Anatomical Context for Tricuspid Valve Insufficiency

MalaCards organs/tissues related to Tricuspid Valve Insufficiency:

39
Heart, Liver

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show all 22)
id Title Authors Year
1
A systematic method for using 3D echocardiography to evaluate tricuspid valve insufficiency in hypoplastic left heart syndrome. ( 25298694 )
2014
2
Pulmonary arterial pressure and right ventricular dilatation independently determine tricuspid valve insufficiency severity in pre-capillary pulmonary hypertension. ( 23409355 )
2012
3
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? ( 21801319 )
2012
4
Surgical treatment of tricuspid valve insufficiency promotes early reverse remodeling in patients with axial-flow left ventricular assist devices. ( 21839483 )
2012
5
The clover technique for the treatment of complex tricuspid valve insufficiency: midterm clinical and echocardiographic results in 66 patients. ( 20117940 )
2010
6
Retrospective analysis of stage I Norwood procedures with tricuspid valve insufficiency in the past 5 years. ( 17669787 )
2007
7
Cardiac bullet embolus after thoracic vena cava penetrating injury causing tricuspid valve insufficiency. ( 17386917 )
2007
8
Acute liver failure as the first manifestation of severe traumatic tricuspid valve insufficiency. ( 16432673 )
2006
9
Diagnosis and treatment of traumatic tricuspid valve insufficiency. ( 14642061 )
2003
10
Traumatic tricuspid valve insufficiency: case report. ( 11499605 )
2001
11
Post-traumatic tricuspid valve insufficiency. 2 cases of delayed clinical manifestation. ( 9339514 )
1997
12
Repair of traumatic tricuspid valve insufficiency by trabecular muscle elevation. ( 7887723 )
1995
13
Fetal and transient neonatal right heart dilatation with severe tricuspid valve insufficiency in association with abnormally S-shaped kinking of the ductus arteriosus. ( 7614140 )
1995
14
Traumatic tricuspid valve insufficiency. Experience in thirteen patients. ( 7967672 )
1994
15
Tricuspid valve insufficiency as a complication of endomyocardial biopsy. ( 14621794 )
1992
16
Endocardial fibroelastosis and tricuspid valve insufficiency in a calf. ( 3610756 )
1987
17
Repair of tricuspid valve insufficiency in patients undergoing double (aortic and mitral) valve replacement. Perioperative mortality and long-term (1 to 20 years) follow-up in 109 patients. ( 3669702 )
1987
18
Transient tricuspid valve insufficiency following acute inferior myocardial infarction. ( 3485873 )
1986
19
Management of tricuspid valve insufficiency. Replacement with Hancock bioprosthesis or suture annuloplasty. ( 511908 )
1979
20
"Balloon valvulotomy" of congenital pulmonary valve stenosis with tricuspid valve insufficiency. ( 519671 )
1979
21
Dynamic tricuspid valve insufficiency produced by a right ventricular thrombus from a pacemaker. ( 699661 )
1978
22
An interventricular septal defect and a tricuspid valve insufficiency in a trotter mare. ( 4426317 )
1974

Variations for Tricuspid Valve Insufficiency

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

Pathways for Tricuspid Valve Insufficiency

GO Terms for Tricuspid Valve Insufficiency

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 ALB FBN1 PAPPA
2 regulation of blood pressure GO:0008217 8.8 ACVRL1 MC3R NPPB

Sources for Tricuspid Valve Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....