Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 14
Trigeminal Nerve Diseases 69


External Ids:

Disease Ontology 12 DOID:561
ICD9CM 34 350.8
ICD10 32 G50 G50.8

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to aspiration pneumonia and cardiovascular organ benign neoplasm, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and L1CAM interactions. The drugs Carbamazepine and Oxcarbazepine have been mentioned in the context of this disorder. Affiliated tissues include trigeminal ganglion, testes and liver, and related phenotypes are behavior/neurological and taste/olfaction

Wikipedia : 72 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 aspiration pneumonia 10.2 TAC1 TRPV1
2 cardiovascular organ benign neoplasm 10.2 TAC1 TRPV1
3 benign perivascular tumor 10.2 TAC1 TRPV1
4 sodium channelopathy-related small fiber neuropathy 10.2 SCN11A SCN9A
5 erythermalgia, primary 10.2 SCN11A SCN9A
6 glomangioma 10.2 TAC1 TRPV1
7 indifference to pain, congenital, autosomal recessive 10.2 SCN11A SCN9A
8 nasal cavity disease 10.2 TAC1 TRPV1
9 brachial plexus lesion 10.2 CRLF1 TAC1
10 bladder disease 10.2 TAC1 TRPV1
11 nose disease 10.2 TAC1 TRPV1
12 interstitial cystitis 10.1 TAC1 TRPV1
13 upper respiratory tract disease 10.1 TAC1 TRPV1
14 irritable bowel syndrome 10.1 TAC1 TRPV1
15 peripheral nervous system disease 10.1 SCN9A TRPV1
16 bronchial disease 10.1 TAC1 TRPV1
17 complex regional pain syndrome 10.1 SCN9A TAC1
18 paroxysmal extreme pain disorder 10.0 SCN11A SCN9A TRPV1
19 cystitis 10.0 TAC1 TRPV1
20 dental pulp disease 10.0 SCN11A TAC1 TRPV1
21 burning mouth syndrome 9.9 SCN9A TAC1 TRPV1
22 somatoform disorder 9.9 SCN9A TAC1 TRPV1
23 epicondylitis 9.8 LIPN TAC1
24 cranial nerve disease 9.8 LIPN MBD1 TRPV1
25 intestinal disease 9.8 TAC1 TRPV1
26 pain agnosia 9.7 LIPN TAC1 TRPV1
27 agnosia 9.6 LIPN TAC1 TRPV1
28 parkinson disease, late-onset 9.6 GSTO1 TAC1 TRPV1
29 paine syndrome 9.6 SCN11A SCN9A TAC1 TRPV1
30 trigeminal neuralgia 8.6 CRLF1 GSTO1 MBD1 MT-TC SCN11A SCN3A

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:

Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:

neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 CRLF1 MBD1 PGRMC1 SCN11A SCN3A SCN9A
2 taste/olfaction MP:0005394 8.8 PGRMC1 SCN9A TRPV1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3 298-46-4 2554
Oxcarbazepine Approved Phase 4 28721-07-5 34312
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Ondansetron Approved Phase 4 99614-02-5 4595
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
7 Analgesics Phase 4,Phase 2,Phase 3
8 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
9 Anticonvulsants Phase 4,Phase 2,Phase 3
10 Antimanic Agents Phase 4,Phase 2,Phase 3
11 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
12 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3
13 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
15 Psychotropic Drugs Phase 4,Phase 2,Phase 3
16 Sodium Channel Blockers Phase 4,Phase 2,Phase 3
17 Tranquilizing Agents Phase 4,Phase 2,Phase 3
18 Anesthetics Phase 4
19 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3
20 Excitatory Amino Acids Phase 4,Phase 2,Phase 3
21 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Dermatologic Agents Phase 4
23 Adjuvants, Anesthesia Phase 4
24 Analgesics, Opioid Phase 4
25 Anesthetics, Dissociative Phase 4
26 Anesthetics, General Phase 4
27 Anesthetics, Intravenous Phase 4
28 Anti-Anxiety Agents Phase 4
29 Antiemetics Phase 4
30 Antipruritics Phase 4
31 Antipsychotic Agents Phase 4
32 Autonomic Agents Phase 4
33 Gastrointestinal Agents Phase 4
34 Narcotics Phase 4
Serotonin Phase 4 50-67-9 5202
36 Serotonin Agents Phase 4
37 Serotonin Antagonists Phase 4
Lamotrigine Approved, Investigational Phase 2, Phase 3 84057-84-1 3878
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
41 calcium channel blockers Phase 2, Phase 3
42 Calcium, Dietary Phase 2, Phase 3
43 Protective Agents Phase 3,Phase 2,Phase 1
44 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
45 Botulinum Toxins Phase 3,Phase 1,Phase 2
46 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
47 Cholinergic Agents Phase 3,Phase 1,Phase 2
48 Neuromuscular Agents Phase 3,Phase 1,Phase 2
49 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
50 Radiation-Protective Agents Phase 3

Interventional clinical trials:

(show all 42)

# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
3 Postoperative Analgesia in Patients With Microvascular Decompression Not yet recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
4 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
5 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
6 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
7 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
8 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
9 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
10 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
11 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
12 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
13 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
14 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Recruiting NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
15 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
16 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
17 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
18 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
19 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
20 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
21 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
22 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Unknown status NCT02427074
23 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598
24 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
25 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
26 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406
27 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
28 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Lidocaine
29 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604
30 Hippocampal Radiation Exposure and Memory Completed NCT00603694
31 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807
32 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 lamotrigine;Placebo
33 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 L-baclofen
34 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Nerve block
35 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
36 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906
37 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Recruiting NCT02801630
38 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810
39 Transcranial Magnetic Stimulation for Facial Pain Recruiting NCT02633306
40 RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT Enrolling by invitation NCT01885299
41 FMRI Assessment After Radiofrequency in Trigeminal Neuralgia Not yet recruiting NCT03305289
42 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

Trigeminal Ganglion, Testes, Liver, Cortex

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors Year
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
11.53 SCN11A SCN3A SCN9A
Show member pathways
11.01 SCN11A SCN3A SCN9A
4 10.28 SCN11A SCN3A SCN9A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.8 SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.83 SCN11A SCN3A SCN9A TRPV1
2 transmembrane transport GO:0055085 9.81 SCN11A SCN3A SCN9A TRPV1
3 regulation of ion transmembrane transport GO:0034765 9.65 SCN11A SCN3A SCN9A
4 ion transmembrane transport GO:0034220 9.62 SCN11A SCN3A SCN9A TRPV1
5 sodium ion transport GO:0006814 9.61 SCN11A SCN3A SCN9A
6 interleukin-12-mediated signaling pathway GO:0035722 9.54 CRLF1 GSTO1
7 sodium ion transmembrane transport GO:0035725 9.54 SCN11A SCN3A SCN9A
8 cellular response to nerve growth factor stimulus GO:1990090 9.49 TAC1 TRPV1
9 response to pain GO:0048265 9.46 TAC1 TRPV1
10 sensory perception of pain GO:0019233 9.43 SCN9A TAC1 TRPV1
11 behavioral response to pain GO:0048266 9.4 SCN9A TRPV1
12 regulation of postsynaptic membrane potential GO:0060078 9.33 SCN11A SCN3A SCN9A
13 neuronal action potential GO:0019228 9.13 SCN11A SCN3A SCN9A
14 membrane depolarization during action potential GO:0086010 8.8 SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.43 SCN11A SCN3A SCN9A
2 sodium channel activity GO:0005272 9.33 SCN11A SCN3A SCN9A
3 ion channel activity GO:0005216 9.26 SCN11A SCN3A SCN9A TRPV1
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN11A SCN3A SCN9A

Sources for Trigeminal Nerve Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
51 Novoseek
54 OMIM via Orphanet
58 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
Loading form....