MCID: TRG003
MIFTS: 30

Trigeminal Nerve Disease malady

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

Aliases & Descriptions for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 14
Trigeminal Nerve Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 35 350.8
ICD10 33 G50 G50.8
UMLS 69 C0029834

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to unverricht-lundborg syndrome and childhood endodermal sinus tumor, and has symptoms including atypical facial pain and neurologic symptoms. An important gene associated with Trigeminal Nerve Disease is MBD1 (Methyl-CpG Binding Domain Protein 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Phase 0 - rapid depolarisation. The drugs Sumatriptan and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include pons, and related phenotype is behavior/neurological.

Wikipedia : 71 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 unverricht-lundborg syndrome 10.1 CRLF1 LIPN
2 childhood endodermal sinus tumor 10.1 SCN11A TAC1
3 corneal ulcer 10.1 CRLF1 TAC1
4 generalized epilepsy with febrile seizures plus 10.1 SCN11A TAC1
5 boutonneuse fever 10.1 LIPN TAC1
6 nerve fibre bundle defect 10.1 LIPN MBD1
7 simultanagnosia 10.0 LIPN TAC1
8 cervical carcinosarcoma 9.9 LIPN TAC1
9 acrocephalopolydactylous dysplasia 9.6 CRLF1 GSTO1 MBD1 MT-TC SCN11A SCN3A
10 adenosquamous bile duct carcinoma 8.5 AP1S2 CRLF1 GSTO1 LIPN MBD1 MSTN

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


atypical facial pain, neurologic symptoms

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 SCN11A SCN3A TAC1 AP1S2 CRLF1 MBD1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3,Phase 2 103628-46-2 5358
2
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
6
Topiramate Approved Phase 4,Phase 2 97240-79-4 5284627
7
Ephedrine Approved Phase 4 299-42-3 9294
8
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
9
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
10
Pseudoephedrine Approved Phase 4 90-82-4 7028
11
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
12
Ondansetron Approved Phase 4 99614-02-5 4595
13
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
14
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
15 triamcinolone acetonide Phase 4
16 Analgesics Phase 4,Phase 2,Phase 3
17
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
18 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3,Phase 2
19 Serotonin Agents Phase 4,Phase 3,Phase 2
20 Narcotics Phase 4
21 Gastrointestinal Agents Phase 4,Phase 1,Phase 2
22 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Analgesics, Opioid Phase 4
24 Hormone Antagonists Phase 4,Phase 2
25 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Anesthetics Phase 4,Phase 2,Phase 3
27 Triamcinolone diacetate Phase 4
28 Triamcinolone hexacetonide Phase 4
29 Hormones Phase 4,Phase 2
30 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Anesthetics, Local Phase 4,Phase 2,Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
33 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
34 Antiemetics Phase 4,Phase 1,Phase 2
35 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Phase 1
36 Antipsychotic Agents Phase 4,Phase 1,Phase 2
37 Autonomic Agents Phase 4,Phase 1,Phase 2
38 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
39 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
40
Histamine Phosphate Phase 4 51-74-1 65513
41 Dexamethasone acetate Phase 4 1177-87-3
42 glucocorticoids Phase 4
43
protease inhibitors Phase 4,Phase 2
44 Adrenergic Agents Phase 4
45 Nasal Decongestants Phase 4
46 Neuroprotective Agents Phase 4,Phase 2
47 HIV Protease Inhibitors Phase 4,Phase 2
48 Dermatologic Agents Phase 4,Phase 3,Phase 2
49 Dexamethasone 21-phosphate Phase 4
50 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 147)
id Name Status NCT ID Phase
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4
2 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4
4 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4
5 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4
6 A Research Study to Examine Cutaneous Allodynia and Cluster Headache Completed NCT00329836 Phase 4
7 Postoperative Analgesia in Patients With Microvascular Decompression Not yet recruiting NCT03152955 Phase 4
8 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4
9 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4
10 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3
11 Topical Intra-Oral Ketoprofen for Migraine Prevention Completed NCT01211795 Phase 3
12 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3
13 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
14 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3
15 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3
16 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3
17 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
18 ALLOD-2 vs. Placebo and vs. Components in the Acute Treatment of Migraine (ANODYNE-1) Recruiting NCT03061734 Phase 2, Phase 3
19 Effects of the Bilateral Mandibular Nerve Block (V3) in Mandibular Osteotomy Recruiting NCT02618993 Phase 3
20 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Recruiting NCT01151631 Phase 3
21 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Recruiting NCT02964338 Phase 3
22 A Study to Evaluate the Efficacy and Safety of TEV-48125 for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3
23 A Study of LY2951742 in Participants With Chronic Cluster Headache Recruiting NCT02438826 Phase 3
24 A Study of LY2951742 in Participants With Episodic Cluster Headache Recruiting NCT02397473 Phase 3
25 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3
26 A Study to Explore the Long-Term Safety of TEV-48125 for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3
27 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3
28 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Not yet recruiting NCT02637648 Phase 3
29 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3
30 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3
31 CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain Terminated NCT00122915 Phase 3
32 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
33 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3
34 TNS for Major Depressive Disorder: a Phase II Randomized Controlled Trial Unknown status NCT02105376 Phase 1, Phase 2
35 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
36 Trigeminal Nerve Stimulation (TNS) in the Treatment of Fibromyalgia Unknown status NCT02120690 Phase 1, Phase 2
37 A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines Unknown status NCT01813591 Phase 2
38 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2
39 Electrical Stimulation in Patients With Unipolar Major Depression Completed NCT02239809 Phase 2
40 Electrical Stimulation in Patients With Unipolar Major Depression Completed NCT02239822 Phase 2
41 Trigeminal Nerve Stimulation for Depression: Dose Finding Completed NCT01343563 Phase 2
42 External Trigeminal Nerve Stimulation for Epilepsy Completed NCT01159431 Phase 2
43 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2
44 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2
45 Civamide Nasal Solution for the Treatment of Dry Eye Completed NCT02116244 Phase 2
46 Effectiveness of a Hand-held Fan for Breathlessness Completed NCT01123902 Phase 2
47 Use Of SB-705498 In The Acute Treatment Of Migraine Completed NCT00269022 Phase 2
48 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2
49 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
50 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

39
Pons

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

id Title Authors Year
1
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )
1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 SCN11A SCN3A TAC1
2
Show member pathways
10.83 SCN11A SCN3A
3 10.1 SCN11A SCN3A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.62 SCN11A SCN3A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of postsynaptic membrane potential GO:0060078 9.16 SCN11A SCN3A
2 neuronal action potential GO:0019228 8.96 SCN11A SCN3A
3 membrane depolarization during action potential GO:0086010 8.62 SCN11A SCN3A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium channel activity GO:0005272 8.96 SCN11A SCN3A
2 voltage-gated sodium channel activity GO:0005248 8.62 SCN11A SCN3A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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