Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 14
Trigeminal Nerve Diseases 69


External Ids:

Disease Ontology 12 DOID:561
ICD9CM 35 350.8
ICD10 33 G50 G50.8
UMLS 69 C0029834

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to peritoneal benign neoplasm and cryptogenic organizing pneumonia, and has symptoms including atypical facial pain and neurologic symptoms. An important gene associated with Trigeminal Nerve Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and L1CAM interactions. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are behavior/neurological and taste/olfaction

Wikipedia : 72 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 peritoneal benign neoplasm 10.6 CRLF1 TRPV1
2 cryptogenic organizing pneumonia 10.4 TAC1 TRPV1
3 bone benign neoplasm 10.4 TAC1 TRPV1
4 congenital absence of both lower leg and foot, bilateral 10.4 SCN11A SCN9A
5 hilar cholangiocellular carcinoma 10.4 TAC1 TRPV1
6 paroxysmal extreme pain disorder 10.3 SCN11A SCN9A
7 hyperpituitarism 10.3 TAC1 TRPV1
8 eyelid neoplasm 10.3 TAC1 TRPV1
9 intestinal impaction 10.3 CRLF1 TAC1
10 brain glioblastoma multiforme 10.3 TAC1 TRPV1
11 dehydration polycythemia 10.3 TAC1 TRPV1
12 uterine corpus dissecting leiomyoma 10.3 TAC1 TRPV1
13 pelvic varices 10.2 TAC1 TRPV1
14 myositis fibrosa 10.2 TAC1 TRPV1
15 pancreatic acinar cell adenocarcinoma 10.2 SCN9A TRPV1
16 spontaneous ocular nystagmus 10.2 TAC1 TRPV1
17 high pressure neurological syndrome 10.2 SCN9A TAC1
18 insensitivity to pain, congenital 10.1 SCN11A SCN9A TRPV1
19 febrile seizures, familial, 3b 10.1 SCN11A SCN9A TRPV1
20 neovascular glaucoma 10.1 TAC1 TRPV1
21 endometrial clear cell adenocarcinoma 10.1 TAC1 TRPV1
22 epulis 10.0 SCN11A TAC1 TRPV1
23 tinea favosa 10.0 SCN9A TAC1 TRPV1
24 placenta accreta 10.0 SCN9A TAC1 TRPV1
25 boutonneuse fever 9.8 LIPN TAC1
26 pleomorphic carcinoma 9.8 LIPN MBD1 TRPV1
27 erythermalgia, primary 9.8 SCN3A SCN9A
28 semantic agnosia 9.6 LIPN TAC1 TRPV1
29 cervical adenosarcoma 9.6 LIPN TAC1 TRPV1
30 benign familial infantile epilepsy 9.6 SCN11A SCN9A TAC1 TRPV1
31 gaba aminotransferase deficiency 9.6 SCN3A SCN9A
32 acrocephalopolydactylous dysplasia 8.2 CRLF1 GSTO1 MBD1 MT-TC SCN11A SCN3A
33 spinal canal intradural extramedullary neoplasm 6.2 CRLF1 GSTO1 LIPN MBD1 MT-TC PGRMC1

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:

Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:

atypical facial pain, neurologic symptoms

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 CRLF1 MBD1 PGRMC1 SCN11A SCN3A SCN9A
2 taste/olfaction MP:0005394 8.8 PGRMC1 SCN9A TRPV1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
Sumatriptan Approved, Investigational Phase 4,Phase 2,Phase 3 103628-46-2 5358
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 50-02-2 5743
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
Ephedrine Approved Phase 4 299-42-3 9294
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
Pseudoephedrine Approved Phase 4 90-82-4 7028
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Ondansetron Approved Phase 4 99614-02-5 4595
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
14 Analgesics Phase 4,Phase 2,Phase 3
15 Anesthetics Phase 4,Phase 1,Phase 2
16 Anesthetics, Local Phase 4,Phase 1,Phase 2
17 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
18 Hormone Antagonists Phase 4,Phase 2,Phase 1
19 Hormones Phase 4,Phase 2,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
21 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
22 triamcinolone acetonide Phase 4
23 Triamcinolone diacetate Phase 4
24 Triamcinolone hexacetonide Phase 4
25 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
Serotonin Phase 4,Phase 2,Phase 3 50-67-9 5202
27 Serotonin Agents Phase 4,Phase 2,Phase 3
28 Antiemetics Phase 4,Phase 1,Phase 2
29 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
31 Autonomic Agents Phase 4,Phase 1,Phase 2
32 BB 1101 Phase 4,Phase 1,Phase 2
33 Dexamethasone acetate Phase 4,Phase 1,Phase 2 1177-87-3
34 Gastrointestinal Agents Phase 4,Phase 1,Phase 2
35 glucocorticoids Phase 4,Phase 1,Phase 2
36 HIV Protease Inhibitors Phase 4,Phase 1,Phase 2
37 Immunosuppressive Agents Phase 4
protease inhibitors Phase 4,Phase 1,Phase 2
39 Adrenergic Agents Phase 4
40 Anti-Asthmatic Agents Phase 4
41 Bronchodilator Agents Phase 4
42 Central Nervous System Stimulants Phase 4
Histamine Phosphate Phase 4 51-74-1 65513
44 Nasal Decongestants Phase 4
45 Respiratory System Agents Phase 4,Phase 2
46 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3
47 Antipruritics Phase 4,Phase 2
48 Dermatologic Agents Phase 4,Phase 2
49 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3
50 Excitatory Amino Acids Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 82)

id Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
3 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
4 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
5 Postoperative Analgesia in Patients With Microvascular Decompression Not yet recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4 PRGF-Endoret;Artificial tears eye-drops
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Topical Intra-Oral Ketoprofen for Migraine Prevention Completed NCT01211795 Phase 3 topical intraoral ketoprofen gel
9 Oral ALLOD-2 vs. Components and vs. Placebo in the Acute Treatment of Migraine (ANODYNE-1) Recruiting NCT03061734 Phase 2, Phase 3 ALLOD-2;ALLOD-2H;Component A (regular dose);Component B;Placebo
10 Efficacy, Safety, and Tolerability of Twice Daily Oral ALLOD-2 vs. Placebo in Episodic Migraine Prevention (ANODYNE-3) Recruiting NCT03194555 Phase 2, Phase 3 ALLOD-2 Capsules;Placebo Capsules
11 Oral ALLOD-2 vs. Oral Sumatriptan and vs. Placebo in the Acute Treatment of Migraine With Associated Nausea (ANODYNE-2) Recruiting NCT03185143 Phase 2, Phase 3 ALLOD-2 Capsules;Sumatriptan 100 mg Capsules;Placebo capsules
12 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
13 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
14 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
15 CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain Terminated NCT00122915 Phase 3
16 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
17 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
18 TNS for Major Depressive Disorder: a Phase II Randomized Controlled Trial Unknown status NCT02105376 Phase 1, Phase 2
19 TNS for Treating Major Depressive Disorder in the Elderly Unknown status NCT02562677 Phase 1, Phase 2
20 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
21 Trigeminal Nerve Stimulation (TNS) in the Treatment of Fibromyalgia Unknown status NCT02120690 Phase 1, Phase 2
22 A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines Unknown status NCT01813591 Phase 2 H.P. Acthar Gel
23 Electrical Stimulation in Patients With Unipolar Major Depression Completed NCT02239809 Phase 2
24 Electrical Stimulation in Patients With Unipolar Major Depression Completed NCT02239822 Phase 2
25 Trigeminal Nerve Stimulation for Depression: Dose Finding Completed NCT01343563 Phase 2
26 External Trigeminal Nerve Stimulation for Epilepsy Completed NCT01159431 Phase 2
27 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
28 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
29 Civamide Nasal Solution for the Treatment of Dry Eye Completed NCT02116244 Phase 2 Civamide Nasal Spray
30 Effectiveness of a Hand-held Fan for Breathlessness Completed NCT01123902 Phase 2
31 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
32 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Recruiting NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
33 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Recruiting NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
34 Treatment of Chronic Migraine Headaches. Recruiting NCT03220113 Phase 1, Phase 2
35 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
36 Civamide Nasal Solution for Postherpetic Neuralgia of the Trigeminal Nerve Terminated NCT01886313 Phase 2 Civamide Nasal Spray;Placebo
37 Trigeminal Nerve Stimulation for Post Traumatic Stress Disorder (PTSD) and Depression Completed NCT01335217 Phase 1
38 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
39 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
40 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
41 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1
42 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
43 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
44 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598
45 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
46 A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube Unknown status NCT00933478
47 Pain Control After Orthognathic Surgery Unknown status NCT01418183
48 Trigeminal Nerve Stimulation for Attention Deficit Hyperactivity Disorder (ADHD) Completed NCT01388530 Early Phase 1
49 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 L-baclofen
50 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 lamotrigine;Placebo

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

Brain, Eye, Cortex, Trigeminal Ganglion, Testes, Liver

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

id Title Authors Year
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
11.53 SCN11A SCN3A SCN9A
Show member pathways
11.01 SCN11A SCN3A SCN9A
4 10.28 SCN11A SCN3A SCN9A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.8 SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.83 SCN11A SCN3A SCN9A TRPV1
2 transmembrane transport GO:0055085 9.8 SCN11A SCN3A SCN9A TRPV1
3 regulation of ion transmembrane transport GO:0034765 9.65 SCN11A SCN3A SCN9A
4 ion transmembrane transport GO:0034220 9.62 SCN11A SCN3A SCN9A TRPV1
5 sodium ion transport GO:0006814 9.61 SCN11A SCN3A SCN9A
6 sodium ion transmembrane transport GO:0035725 9.54 SCN11A SCN3A SCN9A
7 cellular response to nerve growth factor stimulus GO:1990090 9.51 TAC1 TRPV1
8 response to pain GO:0048265 9.46 TAC1 TRPV1
9 sensory perception of pain GO:0019233 9.43 SCN9A TAC1 TRPV1
10 behavioral response to pain GO:0048266 9.4 SCN9A TRPV1
11 regulation of postsynaptic membrane potential GO:0060078 9.33 SCN11A SCN3A SCN9A
12 neuronal action potential GO:0019228 9.13 SCN11A SCN3A SCN9A
13 membrane depolarization during action potential GO:0086010 8.8 SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.43 SCN11A SCN3A SCN9A
2 sodium channel activity GO:0005272 9.33 SCN11A SCN3A SCN9A
3 ion channel activity GO:0005216 9.26 SCN11A SCN3A SCN9A TRPV1
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN11A SCN3A SCN9A

Sources for Trigeminal Nerve Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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