MCID: TRG002
MIFTS: 59

Trigeminal Neuralgia malady

Neuronal category

Summaries for Trigeminal Neuralgia

Sources:
43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards: Trigeminal Neuralgia, also known as tic douloureux, is related to hemifacial spasm and n syndrome. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Sodium channels and transporters: inward current and G-Beta Gamma Signaling. The drugs tocainide and tocainide monohydrochloride and the compounds saxitoxin and Lacosamide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and skin, and related mouse phenotypes are cardiovascular system and behavior/neurological.

NIH Rare Diseases:43 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:44 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:64 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, or Fothergill\'s disease is a neuropathic... more...

Description from OMIM:47 190400

Aliases & Classifications for Trigeminal Neuralgia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 34MedlinePlus, 61UMLS, 22GTR, 57SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

trigeminal neuralgia 8 43 44 10 45 49 47 34 61 22
tic douloureux 43 44 49
trigeminal neuralgia nos 8
trifacial neuralgia 8
trifocal neuralgia 8


External Ids:

Disease Ontology8 DOID:12098
MeSH35 D014277
ICD9CM27 350.1
OMIM47 190400
MESH via Orphanet36 D014277
ICD10 via Orphanet26 G50.0
SNOMED-CT via Orphanet58 31681005
UMLS via Orphanet62 C0040997
ICD1025 G50.0

Related Diseases for Trigeminal Neuralgia

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Clinical Features for Trigeminal Neuralgia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

190400

Clinical synopsis from OMIM:

190400

Drugs & Therapeutics for Trigeminal Neuralgia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trigeminal Neuralgia

Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Search CenterWatch for Trigeminal Neuralgia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Trigeminal Neuralgia

Sources:
22GTR
See all sources

Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia22

Anatomical Context for Trigeminal Neuralgia

Sources:
33MalaCards
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MalaCards organs/tissues related to Trigeminal Neuralgia:

33
Brain, Liver, Skin, T cells, Dorsal root ganglion, Trigeminal ganglion, Tongue

Animal Models for Trigeminal Neuralgia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2EMILIN1, CRP, BMP2, SCN10A, IFT122, CALCA
2MP:00053867.5CALCA, IFT122, MBD1, SCN10A, SCN3A, SCN9A
3MP:00036316.9JMJD6, ESR1, PTN, PCLO, CRLF1, BMP2

Publications for Trigeminal Neuralgia

Sources:
51PubMed
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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
The anatomy of vascular compression in trigeminal neuralgia. (23381734)
2014
2
Facial pain induced by isolated lateral pterygoid pyomyositis misdiagnosed as trigeminal neuralgia. (23400971)
2013
3
Human herpesvirus 1 meningoencephalitis after trigeminal neuralgia surgery. (23068448)
2013
4
Long-term outcome of gamma knife surgery using a retrogasserian petrous bone target for classic trigeminal neuralgia. (23417470)
2013
5
Withdrawal reaction of carbamazepine after neurovascular decompression for trigeminal neuralgia: A preliminary study. (24387898)
2013
6
Trigeminal neuralgia secondary to giant Virchow-Robin spaces: a case report with neuroimaging. (23452387)
2013
7
Detection of compression vessels in trigeminal neuralgia by surface-rendering three-dimensional reconstruction of 1.5- and 3.0-T magnetic resonance imaging. (23022639)
2013
8
Repeated percutaneous balloon compression for recurrent trigeminal neuralgia: a long-term study. (22120364)
2012
9
Surgical management of medically refractory trigeminal neuralgia. (22183181)
2012
10
Outcome of microvascular decompression for trigeminal neuralgia using autologous muscle graft: A five-year prospective study. (23293667)
2012
11
Hematoma of Meckel's cave: a rare possible symptomatic trigeminal neuralgia. (22274788)
2012
12
Accessory mental nerve: case report, review and its role in trigeminal neuralgia. (22076032)
2012
13
Microvascular decompression for trigeminal neuralgia: update. (22547101)
2012
14
Tractography delineates microstructural changes in the trigeminal nerve after focal radiosurgery for trigeminal neuralgia. (22412918)
2012
15
Treatment options for refractory trigeminal neuralgia. (22120317)
2012
16
Trigeminal neuralgia as unusual isolated symptom of fungal paranasal sinusitis in patients with haematological malignancies. (21979557)
2012
17
Non-antiepileptic drugs for trigeminal neuralgia. (21249658)
2011
18
Microvascular decompression for trigeminal neuralgia due to compression by the vertebral artery: report of 3 cases. (21656442)
2011
19
A new animal model of trigeminal neuralgia produced by administration of cobra venom to the infraorbital nerve in the rat. (21778333)
2011
20
A nationwide study of three invasive treatments for trigeminal neuralgia. (21239113)
2011
21
Percutaneous radiofrequency thermocoagulation under fluoroscopic image-guidance for idiopathic trigeminal neuralgia. (22259692)
2011
22
Pharmacological versus microvascular decompression approaches for the treatment of trigeminal neuralgia: clinical outcomes and direct costs. (21941455)
2011
23
Unusual recurrence of trigeminal neuralgia after microvascular decompression by muscle interposal. (21455112)
2011
24
Masseter muscle function after percutaneous balloon compression of trigeminal ganglion for the treatment of trigeminal neuralgia: a neurophysiological follow-up study. (20719561)
2011
25
Preoperative evaluation of neurovascular relationship by using contrast-enhanced and unenhanced 3D time-of-flight MR angiography in patients with trigeminal neuralgia. (21835888)
2011
26
Analgesic effect of diprospan in rats with trigeminal neuralgia. (21671185)
2011
27
Increased risk of stroke after trigeminal neuralgia--a population-based follow-up study. (21511953)
2011
28
Effects of carbamazepine/oxycodone coadministration in the treatment of trigeminal neuralgia. (21652789)
2011
29
Associations between chronic pain and depressive symptoms in patients with trigeminal neuralgia. (22112988)
2011
30
Stereotactic radiosurgery of essential trigeminal neuralgia using Leksell Gamma Knife model C with automatic positioning system: technical nuances and evaluation of outcome in 130 patients with at least 2 years follow-up after treatment. (21701866)
2011
31
A survey on acupuncture treatment of trigeminal neuralgia. (20397469)
2010
32
A variation of the infraorbital nerve: its potential clinical consequence especially in the treatment of trigeminal neuralgia: case report. (20679913)
2010
33
Garlic burn in a patient with trigeminal neuralgia: a case report. (20046486)
2010
34
Rare vascular complication of percutaneous balloon compression of trigeminal neuralgia treated endovascularly. (21990596)
2010
35
Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain. (20219585)
2010
36
Brief report: the long-term outcome of mandibular nerve block with alcohol for the treatment of trigeminal neuralgia. (20584871)
2010
37
Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis. (19138330)
2009
38
Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system. (19925024)
2009
39
Trigeminal neuralgia in the presence of ectatic basilar artery and basilar invagination: treatment by foramen magnum decompression. (19558301)
2009
40
Retreatment of trigeminal neuralgia with Gamma Knife radiosurgery: is there an appropriate cumulative dose? Clinical article. (19326978)
2009
41
Cerebellar swelling after sacrifice of the superior petrosal vein during microvascular decompression for trigeminal neuralgia. (19576780)
2009
42
Gamma knife radiosurgery for multiple sclerosis-related trigeminal neuralgia. (19805732)
2009
43
Percutaneous balloon compression for trigeminal neuralgia. (20214036)
2009
44
Cerebellopontine epidermoid presenting with trigeminal neuralgia for 10 years: a case report. (20066061)
2009
45
A prospective cohort study of microvascular decompression and Gamma Knife surgery in patients with trigeminal neuralgia. (19123904)
2008
46
Surface rendered three-dimensional MR imaging for the evaluation of trigeminal neuralgia and hemifacial spasm. (15519859)
2004
47
Microvascular decompression for treatment of trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia: three surgical approach variations: technical note. (14633313)
2003
48
Simultaneous display of MRA and MPR in detecting vascular compression for trigeminal neuralgia or hemifacial spasm: comparison with oblique sagittal views of MRI. (11003397)
2000
49
Cerebellopontine angle tumor causing contralateral trigeminal neuralgia: a case report. (3497359)
1987
50
Intracranial microvascular decompression for "cryptogenic" hemifacial spasm, trigeminal and glossopharyngeal neuralgia, paroxysmal vertigo and tinnitus: I. Surgical technique and results. (3733416)
1986

Genetic Variations for Trigeminal Neuralgia

Expression for genes affiliated with Trigeminal Neuralgia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

Sources:
12EMD Millipore, 52QIAGEN
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Pathways related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SCN10A, SCN3A, SCN9A
2
Hide members
9.5BMP2, SCN9A, SCN3A, SCN10A
3
Hide members
8.6PTN, CRP, BMP2, SCN9A, SCN3A, SCN10A

Compounds for genes affiliated with Trigeminal Neuralgia

Sources:
29IUPHAR, 11DrugBank, 45Novoseek, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1saxitoxin2910.2SCN9A, SCN3A
2Lacosamide1110.1SCN9A, SCN3A, SCN10A
3dmsa4510.1CALCA, CRP
4batrachotoxin2910.1SCN10A, SCN3A, SCN9A
5qx 314 chloride6010.0SCN10A, SCN3A, SCN9A
6tetrodotoxin citrate6010.0SCN10A, SCN3A, SCN9A
7phrixotoxin 36010.0SCN10A, SCN3A, SCN9A
8teriparatide45 1111.0ESR1, CALCA
9veratridine45 60 2912.0SCN9A, SCN3A, SCN10A
10ibandronate45 1111.0ESR1, CALCA
11alendronate45 50 1111.9CALCA, BMP2, ESR1
12raloxifene45 29 50 1112.9ESR1, BMP2, CALCA
13tibolone459.8ESR1, CRP, CALCA
14pamidronate45 50 1111.8CRP, CALCA
15tetrodotoxin45 60 2911.7CALCA, SCN10A, SCN3A, SCN9A
16risedronate45 60 50 29 1113.6CALCA, ESR1
17testosterone45 60 11 2412.2CALCA, BMP2, CRP, PGRMC1, ESR1
18vegf458.8ESR1, PTN, CRP, BMP2, CALCA

GO Terms for genes affiliated with Trigeminal Neuralgia

Sources:
16Gene Ontology
See all sources

Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.7SCN9A, SCN3A, SCN10A

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.7BMP2, CALCA
2sodium ion transportGO:0068149.6SCN9A, SCN3A, SCN10A
3inflammatory responseGO:0069549.4CRP, BMP2, SCN9A, CALCA

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052489.4SCN9A, SCN3A, SCN10A
2identical protein bindingGO:0428028.2ESR1, EMILIN1, TNN, CALCA, JMJD6, BNIPL

Products for genes affiliated with Trigeminal Neuralgia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trigeminal Neuralgia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet