Trigeminal Neuralgia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Trigeminal Neuralgia

Sources:
⁴²NIH Rare Diseases, ³³MedlinePlus, ⁴³NINDS, ⁶⁴Wikipedia, ⁴⁶OMIM, ³²MalaCards
See all sources

MedlinePlus:³³ Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to diarrhea and arthritis, and has symptoms including autosomal dominant inheritanceand trigeminal neuralgia. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Synaptic transmission ion currents and Interaction between L1 and Ankyrins. The drugs carbamazepine and baclofen and the compounds zoledronic acid and saxitoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are integument and cardiovascular system.

NIH Rare Diseases:⁴² Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor. in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches. last updated: 9/17/2010

NINDS:⁴³ Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:⁶⁴ Trigeminal neuralgia (TN, or TGN), also known as prosopalgia,Fothergill\'s disease, or formerly suicide... more...

Description from OMIM:⁴⁶ 190400

Aliases & Classifications for Trigeminal Neuralgia

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ²³GTR, ⁴³NINDS, ¹¹DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁴⁶OMIM, ³³MedlinePlus, ⁶¹UMLS, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ³⁴MeSH, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Trigeminal Neuralgia, Aliases & Descriptions:

Name: Trigeminal Neuralgia ⁹ ⁴² ²³ ⁴³ ¹¹ ⁴⁴ ⁴⁸ ⁴⁶ ³³ ⁶¹

Tic Douloureux ⁴² ⁴³ ⁴⁸

Trigeminal Neuralgia Nos ⁹

Trifacial Neuralgia ⁹

Trifocal Neuralgia ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases

ICD10: ²⁷ ²⁶

Diseases of the nervous system

Nerve, nerve root and plexus disorders

Disorders of trigeminal nerve

Trigeminal neuralgia

Orphanet: ⁴⁸

Rare neurological diseases

External Ids:

Disease Ontology⁹ DOID:12098

OMIM⁴⁶ 190400

ICD9CM²⁸ 350.1

MeSH³⁴ D014277

SNOMED-CT⁵⁶ 322769008, 193090007, 31681005 155066002, more

MESH via Orphanet³⁵ D014277

ICD10 via Orphanet²⁷ G50.0

UMLS via Orphanet⁶² C0040997

ICD10²⁶ G50.0

UMLS⁶¹ C0040997

Related Diseases for Trigeminal Neuralgia

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 113)

id	Related Disease	Score	Top Affiliating Genes
1	diarrhea	30.0	CRP, CALCA
2	arthritis	29.9	CRP, CALCA, BMP2
3	hemifacial spasm	10.9
4	multiple sclerosis	10.8
5	glossopharyngeal neuralgia	10.7
6	arteriovenous malformation	10.6
7	meningioma	10.5
8	headache	10.5
9	lumbar disc disease	10.5	BMP2
10	arachnoiditis	10.4
11	blindness	10.4
12	trigeminal autonomic cephalalgia	10.4
13	parotitis	10.4	PGRMC1
14	dravet syndrome	10.4	SCN3A
15	arteriovenous fistula	10.4
16	burns	10.4
17	hypertension	10.4
18	cerebellopontine angle tumor	10.4
19	arachnoid cysts	10.4
20	persistent idiopathic facial pain	10.4
21	spondylolisthesis	10.3	BMP2, PGRMC1
22	paroxysmal extreme pain disorder	10.3	SCN9A
23	temporal arteritis	10.3
24	burning mouth syndrome	10.3
25	petrositis	10.3
26	meningoencephalitis	10.3
27	choroiditis	10.3
28	migraine	10.3
29	paroxysmal hemicrania	10.3
30	cavernous malformation	10.3
31	chronic pain	10.3
32	facial neuralgia	10.3
33	leprosy	10.3
34	pyelonephritis	10.2	CRP
35	acute lymphoblastic leukemia	10.1
36	burkitt's lymphoma	10.1
37	charcot-marie-tooth disease	10.1
38	chronic inflammatory demyelinating polyneuropathy	10.1
39	hematopoietic stem cell transplantation	10.1
40	hydrocephalus	10.1
41	leukemia	10.1
42	pancreatic cancer	10.1
43	progressive hemifacial atrophy	10.1
44	rheumatoid arthritis	10.1
45	sinusitis	10.1
46	relapsing polychondritis	10.1
47	choroid plexus papilloma	10.1
48	dandy-walker syndrome	10.1
49	spondylosis	10.1
50	pharyngitis	10.1

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:

Symptoms for Trigeminal Neuralgia

Sources:
⁴⁶OMIM, ⁵⁸The Human Phenotype Ontology
See all sources

Symptoms by clinical synopsis from OMIM:

190400

Clinical features from OMIM:

190400

HPO human phenotypes related to Trigeminal Neuralgia:

id	Description	Frequency	HPO Source Accession
1	autosomal dominant inheritance		HP:0000006
2	trigeminal neuralgia		HP:0100661

Drugs & Therapeutics for Trigeminal Neuralgia

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

baclofen

carbamazepine

tizanidine

tizanidine hydrochloride

tocainide

tocainide monohydrochloride

Genetic Tests for Trigeminal Neuralgia

Sources:
²³GTR
See all sources

Genetic tests related to Trigeminal Neuralgia:

id	Genetic test	Affiliating Genes
1	Trigeminal Neuralgia²³

Anatomical Context for Trigeminal Neuralgia

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Trigeminal Neuralgia:

³²

Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	8.1	JMJD6, CALCA, ESR1, SCN9A, SCN10A
2	cardiovascular system phenotype	MP:0005385	7.7	SCN10A, ESR1, BMP2, CALCA, CRP, JMJD6
3	behavior/neurological phenotype	MP:0005386	7.7	SCN10A, SCN9A, SCN3A, ESR1, CALCA, CRLF1
4	nervous system phenotype	MP:0003631	7.3	MBD1, SCN10A, SCN9A, ESR1, BMP2, CALCA
5	mortality/aging	MP:0010768	7.2	SCN9A, SCN3A, ESR1, BMP2, CALCA, CRLF1

Publications for Trigeminal Neuralgia

Sources:
⁵¹PubMed
See all sources

Articles related to Trigeminal Neuralgia:

(show top 50) (show all 562)

id	Title	Authors	Year
1	Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes. (25270137)	Bohman L.E.... Lee J.Y.	2014
2	Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)	Wang Y.N.... Li S.T.	2014
3	Tentorial dural arteriovenous fistula manifesting as contralateral trigeminal neuralgia: resolution after transarterial Onyx embolization. (24297368)	Lu X.... Xu F.	2013
4	Dyna-CT-assisted percutaneous microballoon compression for trigeminal neuralgia. (23904451)	Huo X.... Luo J.	2013
5	Salvage treatment of trigeminal neuralgia by occipital nerve stimulation. (24104562)	Fontaine D.... Lanteri-Minet M.	2013
6	Facial pain induced by isolated lateral pterygoid pyomyositis misdiagnosed as trigeminal neuralgia. (23400971)	Kim K.S.	2013
7	Non-antiepileptic drugs for trigeminal neuralgia. (24297506)	Zhang J.... Zakrzewska J.M.	2013
8	Comparative Evaluation of Surgical Procedures for Trigeminal Neuralgia. (24431878)	Parmar M.... Naidu P.	2013
9	A Review of Percutaneous Treatments for Trigeminal Neuralgia. (24064481)	Cheng J.S.... Barbaro N.M.	2013
10	Repeated percutaneous balloon compression for recurrent trigeminal neuralgia: a long-term study. (22120364)	Chen J.F.... Lee S.T.	2012
11	Misoprostol as a therapeutic option for trigeminal neuralgia in patients with multiple sclerosis. (22925476)	Pfau G.... Hachenberg T.	2012
12	Stereotactic radiosurgery for trigeminal neuralgia: outcomes and complications. (21815736)	Loescher A.R.... Rowe J.	2012
13	Botulinum toxin for trigeminal neuralgia--do we have the evidence? (22990690)	Zakrzewska J.M.	2012
14	Non-antiepileptic drugs for trigeminal neuralgia. (21249658)	Yang M.... Zakrzewska J.M.	2011
15	Foramen ovale cannulation guided by intra-operative computed tomography with integrated neuronavigation for the treatment of trigeminal neuralgia. (21503836)	Lin M.H.... Yang J.T.	2011
16	Efficacy, safety and tolerability of duloxetine in idiopathic trigeminal neuralgia. (22187799)	Anand K.S.... Shewtengna .	2011
17	Microvascular decompression for trigeminal neuralgia: visualization of results in a 3D stereoscopic virtual reality environment. (21506062)	Christiano L.D.... Gandhi C.D.	2011
18	Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation. (21576839)	Gong J.... Liang H.	2011
19	Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report. (20674409)	Bohluli B.... Moharamnejad N.	2011
20	Identification of a persistent primitive trigeminal artery following the transposition technique for trigeminal neuralgia: a case report. (22059208)	Kato N.... Abe T.	2011
21	Microvascular decompression for trigeminal neuralgia due to compression by the vertebral artery: report of 3 cases. (21656442)	Yamahata H.... Arita K.	2011
22	Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)	Skrap M.... Tuniz F.	2010
23	Surgical treatment of trigeminal neuralgia. Results from the use of glycerol injection, microvascular decompression, and rhizotomia. (20953805)	Degn J.... Brennum J.	2010
24	Assessment and treatment of trigeminal neuralgia. (20852542)	Zakrzewska J.M.	2010
25	Trigeminal Neuralgia in an HIV Patient. (20300421)	Hashmi M.A.... Saha B.	2010
26	Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases. (21121797)	Verheul J.B.... Beute G.N.	2010
27	Lipomatosis of the trigeminal nerve causing trigeminal neuralgia: case report and literature review. (21311625)	Maratos E.C.... Cervio A.	2010
28	Image registration strategy of T(1)-weighted and FIESTA MRI sequences in trigeminal neuralgia gamma knife radiosurgery. (20530977)	Wang T.J.... Liu T.	2010
29	Frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492609)	Chen J.C.... Girvigian M.R.	2010
30	A survey on acupuncture treatment of trigeminal neuralgia. (20397469)	Tian L.F.	2010
31	Treatment of trigeminal neuralgia with percutaneous glycerol injection into Meckel's cavity: experience in 4012 patients. (20717747)	Chen L.... Zou Y.	2010
32	The operative findings in re-do microvascular decompression for recurrent trigeminal neuralgia. (20158349)	Ugwuanyi U.C.... Kitchen N.D.	2010
33	A case of trigeminal neuralgia complicated by ipsilateral temporal arteritis. (20063018)	Kawaguchi Y.... Hirota K.	2010
34	Salvage gamma knife stereotactic radiosurgery for surgically refractory trigeminal neuralgia. (19084354)	Little A.S.... Rogers C.L.	2009
35	Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. (19169626)	Perrini P.... Leggate J.	2009
36	Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis. (19138330)	Putzki N.... Katsarava Z.	2009
37	Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia. (19475723)	Jorns T.P.... Zakrzewska J.M.	2009
38	Altered somatosensory processing in trigeminal neuralgia. (19365802)	Blatow M.... Stippich C.	2009
39	Peduncular hallucinosis following microvascular decompression for trigeminal neuralgia without direct brainstem injury: case report. (19229466)	Miyazawa T.... Yasumoto Y.	2009
40	Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system. (19925024)	Zahra H.... Butler E.B.	2009
41	Trigeminal neuralgia secondary to meningioma of petroclival localization. (19408646)	JurjeviA8 A.... Bosnar A.	2009
42	Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. (18958387)	Arrese I.... Lobato R.D.	2008
43	Long-term pain response and quality of life in patients with typical trigeminal neuralgia treated with gamma knife stereotactic radiosurgery. (19005382)	Little A.S.... Rogers C.L.	2008
44	The Treatment Outcome of Elderly Patients with Idiopathic Trigeminal Neuralgia : Micro-Vascular Decompression versus Gamma Knife Radiosurgery. (19096677)	Oh I.H.... Lim Y.J.	2008
45	Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia]. (16430179)	Huang C.J.... Yi P.	2005
46	Demonstration of neurovascular compression in trigeminal neuralgia and hemifacial spasm with magnetic resonance imaging: comparison with surgical findings in 60 consecutive cases. (12648904)	Fukuda H.... Okumura R.	2003
47	Symptomatic trigeminal-autonomic cephalalgia evolving to trigeminal neuralgia: report of a case associated with dual pathology. (11903287)	Kowacs P.A.... Vincent M.	2001
48	Trigeminal neuralgia caused by contralateral cerebellopontine angle meningioma - case report. (11786938)	Sepehrnia A.... Schulte T.	2001
49	Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)	Abdeen K.... Kanno T.	2000
50	Long-term outcome after operation for trigeminal neuralgia in patients with posterior fossa tumors. (8622156)	Barker F.G.... Jho H.D.	1996

Genes related to Trigeminal Neuralgia

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Trigeminal Neuralgia:

(show all 12)

- Elite gene

id	Symbol	Description	Score	Implication
1	BMP2	bone morphogenetic protein 2	20.91	GeneCards inferred via : Disorders (show sections)
2	CRLF1	cytokine receptor-like factor 1	19.20	GeneCards inferred via : Disorders (show sections)
3	MBD1	methyl-CpG binding domain protein 1	17.54	GeneCards inferred via : Disorders (show sections)
4	PGRMC1	progesterone receptor membrane component 1	15.87	GeneCards inferred via : Disorders (show sections)
5	SCN10A	sodium channel, voltage-gated, type X, alpha subunit	14.20	GeneCards inferred via : Publications (show sections)
6	SCN3A	sodium channel, voltage-gated, type III, alpha subunit	12.54	GeneCards inferred via : Publications (show sections)
7	CALCA	calcitonin-related polypeptide alpha	10.87	GeneCards inferred via : Publications (show sections)
8	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	9.20	GeneCards inferred via : Publications (show sections)
9	CRP	C-reactive protein, pentraxin-related	7.54	GeneCards inferred via : Publications (show sections)
10	ESR1	estrogen receptor 1	5.87	GeneCards inferred via : Publications (show sections)
11	BNIPL	BCL2/adenovirus E1B 19kD interacting protein like	4.20	GeneCards inferred via : Disorders (show sections)
12	JMJD6	jumonji domain containing 6	2.54	GeneCards inferred via : Disorders (show sections)

Products for genes related to Trigeminal Neuralgia disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	11	-	12	12
2	Novus Biologicals	11	9	12	-

Variations for Trigeminal Neuralgia

Expression for genes affiliated with Trigeminal Neuralgia

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

Sources:
⁴⁹PathCards, ¹³EMD Millipore, ⁵⁴Reactome, ⁵²QIAGEN
See all sources

Pathways related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Synaptic transmission ion currents¹³	9.7	SCN9A, SCN10A
2	Interaction between L1 and Ankyrins⁵⁴	9.6	SCN3A, SCN9A
3	Sodium channels and transporters inward current¹³ Show member pathways HCN channels⁵⁴	9.3	SCN3A, SCN9A, SCN10A
4	Neuropathic Pain-Signaling in Dorsal Horn Neurons⁵² Show member pathways Cholera Infection⁵² Aldosterone Signaling in Epithelial Cells⁵²	9.3	SCN3A, SCN9A, SCN10A
5	G-Beta Gamma Signaling⁵² Show member pathways CRHR Pathway⁵² Relaxin Pathway⁵² GHRH Signaling⁵² Hedgehog Signaling in Mammals⁵²	9.0	SCN10A, SCN9A, SCN3A, BMP2
6	Activation of cAMP-Dependent PKA⁵² Show member pathways PKA Signaling⁵² Activation of PKA through GPCR⁵² cAMP Pathway⁵²	8.5	SCN10A, SCN9A, SCN3A, BMP2, CRP

Compounds for genes affiliated with Trigeminal Neuralgia

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ²⁵HMDB
See all sources

Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 32)

id	Compound	Score	Top Affiliating Genes
1	zoledronic acid⁴⁴	10.1	BMP2, CALCA
2	saxitoxin²⁹	10.0	SCN3A, SCN9A
3	lidocaine⁴⁴ ²⁹ ¹²	11.9	SCN9A, SCN10A
4	cerivastatin⁵⁰ ⁴⁴ ²⁹ ¹²	12.9	BMP2, CRP
5	dmsa⁴⁴	9.9	CRP, CALCA
6	zonisamide⁴⁴ ⁵⁰ ¹²	11.9	SCN9A, SCN3A
7	pamidronate⁴⁴ ⁵⁰ ¹²	11.9	CALCA, CRP
8	pmma⁴⁴	9.8	CRP, CALCA
9	deoxypyridinoline⁴⁴	9.8	CALCA, CRP
10	teriparatide⁴⁴ ¹²	10.8	ESR1, CALCA
11	ibandronate⁴⁴ ¹²	10.8	CALCA, ESR1
12	risedronate⁴⁴ ⁵⁰ ²⁹ ⁶⁰ ¹²	13.7	CALCA, ESR1
13	batrachotoxin²⁹	9.7	SCN3A, SCN9A, SCN10A
14	nitroglycerin⁴⁴ ¹²	10.7	CALCA, CRP
15	qx 314 chloride⁶⁰	9.7	SCN10A, SCN9A, SCN3A
16	tetrodotoxin citrate⁶⁰	9.7	SCN10A, SCN9A, SCN3A
17	fluvastatin⁴⁴ ⁵⁰ ²⁹ ¹²	12.7	CRP, BMP2
18	phrixotoxin 3⁶⁰	9.7	SCN10A, SCN9A, SCN3A
19	veratridine⁴⁴ ⁶⁰ ²⁹	11.7	SCN3A, SCN9A, SCN10A
20	25-hydroxyvitamin d⁴⁴	9.7	CALCA, CRP
21	alendronate⁴⁴ ⁵⁰ ¹²	11.5	CALCA, BMP2, ESR1
22	progestins⁴⁴	9.5	ESR1, PGRMC1
23	raloxifene⁴⁴ ⁵⁰ ²⁹ ¹²	12.5	ESR1, BMP2, CALCA
24	methacholine⁴⁴ ⁵⁰ ¹²	11.4	CALCA, CRP
25	cyclophosphamide⁴⁴ ⁵⁰ ¹²	11.4	ESR1, BMP2, CRP
26	vitamin d⁴⁴	9.4	CALCA, BMP2, ESR1
27	tibolone⁴⁴	9.3	ESR1, CALCA, CRP
28	tetrodotoxin⁴⁴ ⁶⁰ ²⁹	11.3	SCN10A, SCN9A, SCN3A, CALCA
29	prostaglandin f2alpha⁴⁴	9.2	CRP, CALCA
30	estrogen⁴⁴	8.9	PGRMC1, ESR1, BMP2, CALCA
31	vegf⁴⁴	8.9	ESR1, BMP2, CALCA, CRP
32	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.7	PGRMC1, ESR1, BMP2, CALCA, CRP

GO Terms for genes affiliated with Trigeminal Neuralgia

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel complex	GO:001518	9.0	SCN3A, SCN9A, SCN10A
2	extracellular space	GO:005615	9.0	CRLF1, CRP, CALCA, BMP2

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of heart rate	GO:002027	9.7	CALCA, SCN10A
2	positive regulation of ossification	GO:045778	9.5	CALCA, BMP2
3	sodium ion transport	GO:006814	9.4	SCN3A, SCN9A, SCN10A
4	sodium ion transmembrane transport	GO:035725	9.3	SCN3A, SCN9A, SCN10A
5	inflammatory response	GO:006954	8.7	SCN9A, BMP2, CALCA, CRP

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:005496	9.5	ESR1, PGRMC1
2	voltage-gated sodium channel activity	GO:005248	9.3	SCN3A, SCN9A, SCN10A
3	identical protein binding	GO:042802	7.8	BNIPL, ESR1, CALCA, JMJD6
4	protein binding	GO:005515	6.3	BNIPL, PGRMC1, ESR1, BMP2, CALCA, CRP

Products for genes affiliated with Trigeminal Neuralgia

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Trigeminal Neuralgia

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: TRG002 MIFTS: 67	Trigeminal Neuralgia malady Rare diseases, Neuronal diseases categories
2 symptoms, 6 drugs, 12 genes, 7 tissues, 113 related diseases, clinical trials, genetic tests Download this MalaCard Expand all tables

Trigeminal Neuralgia malady