MCID: TRG002
MIFTS: 63

Trigeminal Neuralgia malady

Neuronal diseases category

Summaries for Trigeminal Neuralgia

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards: Trigeminal Neuralgia, also known as tic douloureux, is related to migraine and neuroma. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Sodium channels and transporters: inward current and G-Beta Gamma Signaling. The drugs baclofen and carbamazepine and the compounds saxitoxin and Lacosamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are cardiovascular system and behavior/neurological.

NIH Rare Diseases:42 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:43 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:63 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, or Fothergill\'s disease is a neuropathic... more...

Description from OMIM:46 190400

Aliases & Classifications for Trigeminal Neuralgia

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

trigeminal neuralgia 8 42 22 43 10 44 48 46 33 60
tic douloureux 42 43 48
trigeminal neuralgia nos 8
trifacial neuralgia 8
trifocal neuralgia 8


External Ids:

Disease Ontology8 DOID:12098
MeSH34 D014277
ICD9CM27 350.1
OMIM46 190400
MESH via Orphanet35 D014277
ICD10 via Orphanet26 G50.0
SNOMED-CT via Orphanet57 31681005
UMLS via Orphanet61 C0040997
ICD1025 G50.0

Related Diseases for Trigeminal Neuralgia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Clinical Features for Trigeminal Neuralgia

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46OMIM
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Clinical features from OMIM:

190400

Clinical synopsis from OMIM:

190400

Drugs & Therapeutics for Trigeminal Neuralgia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Trigeminal Neuralgia

Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Search CenterWatch for Trigeminal Neuralgia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trigeminal Neuralgia

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22GTR
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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia22

Anatomical Context for Trigeminal Neuralgia

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32MalaCards
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MalaCards organs/tissues related to Trigeminal Neuralgia:

32
Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Trigeminal Neuralgia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2EMILIN1, CRP, BMP2, SCN10A, IFT122, CALCA
2MP:00053867.5CALCA, IFT122, MBD1, SCN10A, SCN3A, SCN9A
3MP:00036316.9JMJD6, ESR1, PTN, PCLO, CRLF1, BMP2

Publications for Trigeminal Neuralgia

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50PubMed
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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Tentorial dural arteriovenous fistula manifesting as contralateral trigeminal neuralgia: resolution after transarterial Onyx embolization. (24297368)
2013
2
Diffusion tensor imaging (DTI) study of a trigeminal neuralgia due to large venous angioma. (22391674)
2013
3
Typical versus atypical trigeminal neuralgia and other factors that may affect results of neurosurgical treatment. (22366746)
2013
4
Trigeminal neuralgia: a new neuroimaging perspective. (23111209)
2013
5
Impact of target location on the response of trigeminal neuralgia to stereotactic radiosurgery. (24313616)
2013
6
Herpes simplex encephalitis following microvascular decompression for trigeminal neuralgia. (23289817)
2013
7
Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia? (24251833)
2013
8
Radiosurgical management of trigeminal neuralgia. (24093579)
2013
9
Comparison of trigeminal neuralgia radiosurgery plans using two film detectors for the commissioning of small photon beams. (24257267)
2013
10
Predictive variables for the successful treatment of trigeminal neuralgia with gamma knife radiosurgery. (21849918)
2012
11
Microvascular decompression for trigeminal neuralgia in patients with and without prior stereotactic radiosurgery. (22120253)
2012
12
Trigeminal neuralgia: diagnostic criteria, clinical aspects and treatment outcomes. A retrospective study. (23033842)
2012
13
The unnerving dilemma: understanding trigeminal neuralgia. (22308573)
2012
14
Management of bilateral trigeminal neuralgia with trigeminal radiofrequency rhizotomy: a treatment strategy for the life-long disease. (22392016)
2012
15
Management of intraneural vessels during microvascular decompression surgery for trigeminal neuralgia. (22120295)
2012
16
Trigeminal neuralgia associated with cerebellopontine angle lipoma in childhood. (23796885)
2012
17
Do carbamazepine, gabapentin, or other anticonvulsants exert sufficient radioprotective effects to alter responses from trigeminal neuralgia radiosurgery? (22417801)
2012
18
Imaging of vascular causes of trigeminal neuralgia. (23177241)
2012
19
Trigeminal neuralgia: diagnosis and treatment. (22251500)
2011
20
Microvascular decompression for trigeminal neuralgia. (20653391)
2011
21
Structural abnormalities of the trigeminal root revealed by diffusion tensor imaging in patients with trigeminal neuralgia caused by neurovascular compression: a prospective, double-blind, controlled study. (21835547)
2011
22
Feasibility of multiple repeat gamma knife radiosurgeries for trigeminal neuralgia: a case report and review of the literature. (21904556)
2011
23
Trigeminal neuralgia relief with intrathecal ziconotide. (21494183)
2011
24
Surgical treatment of trigeminal neuralgia. Results from the use of glycerol injection, microvascular decompression, and rhizotomia. (20953805)
2010
25
Image registration strategy of T(1)-weighted and FIESTA MRI sequences in trigeminal neuralgia gamma knife radiosurgery. (20530977)
2010
26
Severe psychosocial compromise in idiopathic trigeminal neuralgia: case report. (20447314)
2010
27
Trigeminal neuralgia may be caused by abnormality of the trigger zone. (20053504)
2010
28
Atypical trigeminal neuralgia: a consequence of central sensitization? (20172658)
2010
29
Does trigeminal neuralgia always get worse over time? (20980941)
2010
30
A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. (21222296)
2010
31
Trigeminal neuralgia: a plea for microvascular decompression as the first surgical option. Anatomy should prevail. (19756353)
2010
32
Operative strategies for minimizing hearing loss associated with microvascular decompression for trigeminal neuralgia. (21299996)
2010
33
Factors that influence outcome of percutaneous balloon compression in the treatment of trigeminal neuralgia. (20881557)
2010
34
Trigeminal neuralgia secondary to meningioma of petroclival localization. (19408646)
2009
35
Treatment resistant trigeminal neuralgia relieved with oral sumatriptan: a case report. (19830141)
2009
36
Trigeminal neuralgia. (18948729)
2009
37
Comment on AAN-EFNS guidelines on trigeminal neuralgia management. (19405206)
2009
38
SUNCT syndrome or first division trigeminal neuralgia associated with cerebellar hypoplasia. (19760043)
2009
39
Microvascular decompression as a surgical management for trigeminal neuralgia: a critical review of the literature. (19439841)
2009
40
Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia. (19699781)
2009
41
Diagnostic evaluation and treatment of trigeminal neuralgia. (19586587)
2009
42
Long-term outcomes of Gamma Knife radiosurgery for classic trigeminal neuralgia: implications of treatment and critical review of the literature. Clinical article. (19326987)
2009
43
Long-term pain response and quality of life in patients with typical trigeminal neuralgia treated with gamma knife stereotactic radiosurgery. (19005382)
2008
44
Could calcitonin be a useful therapeutic agent for trigeminal neuralgia? (18343043)
2008
45
Trigeminal and concurrent glossopharyngeal neuralgia secondary to lateral medullary infarction. (16552020)
2006
46
Trigeminal neuralgia associated with achondroplasia. Case report with literature review. (11731870)
2001
47
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
48
Removal of petrous apex meningioma and microvascular decompression for trigeminal neuralgia through the anterior petrosal approach. Case report. (10396120)
1999
49
Follow-up results of microvascular decompression in trigeminal neuralgia and hemifacial spasm. (8971823)
1997
50
Familial trigeminal and glossopharyngeal neuralgia. (550953)
1979

Genetic Variations for Trigeminal Neuralgia

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Expression for genes affiliated with Trigeminal Neuralgia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

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12EMD Millipore, 51QIAGEN
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Pathways related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SCN10A, SCN3A, SCN9A
2
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9.5BMP2, SCN9A, SCN3A, SCN10A
3
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8.6PTN, CRP, BMP2, SCN9A, SCN3A, SCN10A

Compounds for genes affiliated with Trigeminal Neuralgia

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28IUPHAR, 11DrugBank, 44Novoseek, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1saxitoxin2810.2SCN9A, SCN3A
2Lacosamide1110.1SCN9A, SCN3A, SCN10A
3dmsa4410.1CALCA, CRP
4batrachotoxin2810.1SCN10A, SCN3A, SCN9A
5qx 314 chloride5910.0SCN10A, SCN3A, SCN9A
6tetrodotoxin citrate5910.0SCN10A, SCN3A, SCN9A
7phrixotoxin 35910.0SCN10A, SCN3A, SCN9A
8teriparatide44 1111.0ESR1, CALCA
9veratridine44 59 2812.0SCN9A, SCN3A, SCN10A
10ibandronate44 1111.0ESR1, CALCA
11alendronate44 49 1111.9CALCA, BMP2, ESR1
12raloxifene44 28 49 1112.9ESR1, BMP2, CALCA
13tibolone449.8ESR1, CRP, CALCA
14pamidronate44 49 1111.8CRP, CALCA
15tetrodotoxin44 59 2811.7CALCA, SCN10A, SCN3A, SCN9A
16risedronate44 59 49 28 1113.6CALCA, ESR1
17testosterone44 59 11 2412.2CALCA, BMP2, CRP, PGRMC1, ESR1
18vegf448.8ESR1, PTN, CRP, BMP2, CALCA

GO Terms for genes affiliated with Trigeminal Neuralgia

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16Gene Ontology
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Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.7SCN9A, SCN3A, SCN10A

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.7BMP2, CALCA
2sodium ion transportGO:0068149.6SCN9A, SCN3A, SCN10A
3inflammatory responseGO:0069549.4CRP, BMP2, SCN9A, CALCA

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052489.4SCN9A, SCN3A, SCN10A
2identical protein bindingGO:0428028.2ESR1, EMILIN1, TNN, CALCA, JMJD6, BNIPL

Products for genes affiliated with Trigeminal Neuralgia

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Sources for Trigeminal Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet