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MCID: TRG002
MIFTS: 57

Trigeminal Neuralgia malady

Categories: Rare diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trigeminal Neuralgia

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Aliases & Descriptions for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 54 12 50 51 56 52 41 42 14 69
Trigeminal Neuralgia [no Drugs Here] 12 29
Tic Douloureux 50 51
Trigeminal Neuralgia Nos 12
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

HPO:

32
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 56  
Rare neurological diseases


External Ids:

OMIM 54 190400
Disease Ontology 12 DOID:12098
ICD10 33 G50.0
ICD9CM 35 350.1
MeSH 42 D014277
Orphanet 56 ORPHA221091
MESH via Orphanet 43 D014277
UMLS via Orphanet 70 C0040997
ICD10 via Orphanet 34 G50.0
UMLS 69 C0040997
Sources

Summaries for Trigeminal Neuralgia

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NINDS : 51 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as trigeminal neuralgia [no drugs here], is related to glossopharyngeal neuralgia and epidermoid brain tumor, and has symptoms including back pain, facial pain and headache. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Cardiac conduction. The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

NIH Rare Diseases : 50 trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain lasts a few seconds to a few minutes, and usually on only one side of the face. it can also cause muscle spasms in the face the same time as the pain. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theĀ face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches. last updated: 2/17/2016

MedlinePlus : 41 trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

Wikipedia : 71 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 glossopharyngeal neuralgia 11.4
2 epidermoid brain tumor 11.0
3 trigeminal trophic syndrome 11.0
4 hemifacial atrophy, progressive 11.0
5 hemifacial spasm 10.4
6 arteriovenous malformation 10.1
7 headache 10.1
8 chronic eosinophilic pneumonia 10.1 ESR1 SLC6A4
9 arachnoiditis 10.0
10 hydrocephalus 10.0
11 cerebellopontine angle tumor 10.0
12 persistent idiopathic facial pain 10.0
13 leprosy 9.9
14 arteriovenous fistula 9.9
15 arachnoid cysts 9.9
16 cavernous malformation 9.9
17 burns 9.9
18 systemic scleroderma 9.9 BMP2 ESR1
19 charcot-marie-tooth disease, axonal, type 2h 9.9 SCN10A SCN11A
20 apodia, unilateral 9.9 SCN10A SCN11A SCN9A
21 paroxysmal extreme pain disorder 9.9 SCN10A SCN11A SCN9A
22 febrile seizures, familial, 3b 9.8 SCN10A SCN11A SCN9A
23 auriculocondylar syndrome 1 9.8 SCN10A SCN11A SCN9A
24 meningoencephalitis 9.8
25 aneurysm 9.8
26 petrositis 9.8
27 burning mouth syndrome 9.8
28 chronic pain 9.8
29 choroiditis 9.8
30 glioma 9.8
31 sinusitis 9.8
32 petroclival meningioma 9.8
33 paroxysmal hemicrania 9.8
34 lymphoma 9.8
35 neuropathy 9.8
36 temporal arteritis 9.8
37 generalized epilepsy with febrile seizures plus 9.8 SCN10A SCN11A SCN9A
38 cerebellar hypoplasia 9.7
39 myofascial pain syndrome 9.7
40 encephalitis 9.7
41 squamous cell carcinoma 9.7
42 ataxia 9.7
43 arthritis 9.7
44 meningocele 9.7
45 neuroma 9.7
46 intracranial hypotension 9.7
47 black hairy tongue 9.7
48 tooth disease 9.7
49 spondylosis 9.7
50 ganglioneuroma 9.7

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis, Disease Progression, Modifier of

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Symptoms by clinical synopsis from OMIM:

190400

Clinical features from OMIM:

190400

Human phenotypes related to Trigeminal Neuralgia:

32
id Description HPO Frequency HPO Source Accession
1 trigeminal neuralgia 32 HP:0100661

UMLS symptoms related to Trigeminal Neuralgia:


back pain, facial pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, atypical facial pain, orofacial pain, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.53 SLC6A4 MBD1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 SCN11A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.53 MBD1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.53 SCN11A SLC6A4 MBD1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.53 SCN11A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.53 SCN11A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.53 SLC6A4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.53 MBD1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 SLC6A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 SLC6A4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.53 MBD1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 SLC6A4
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.53 MBD1

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 SCN9A SLC6A4 CRLF1 ESR1 MBD1 SCN10A
2 nervous system MP:0003631 9.23 BMP2 CRLF1 ESR1 MBD1 SCN10A SCN11A
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Artemether Approved Phase 4 71963-77-4 119380 68911
5
Lumefantrine Approved Phase 4 82186-77-4 6437380
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
8
Ondansetron Approved Phase 4 99614-02-5 4595
9
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
10
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
11 Analgesics Phase 4,Phase 2,Phase 3
12 Anesthetics Phase 4,Phase 2,Phase 3
13 Anesthetics, Local Phase 4,Phase 2,Phase 3
14 Antiemetics Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Autonomic Agents Phase 4
18 BB 1101 Phase 4
19 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
20 Dexamethasone 21-phosphate Phase 4
21 Dexamethasone acetate Phase 4 1177-87-3
22 Gastrointestinal Agents Phase 4
23 glucocorticoids Phase 4
24 HIV Protease Inhibitors Phase 4
25 Hormone Antagonists Phase 4
26 Hormones Phase 4
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
28 Immunosuppressive Agents Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
30
protease inhibitors Phase 4
31 triamcinolone acetonide Phase 4
32 Triamcinolone diacetate Phase 4
33 Triamcinolone hexacetonide Phase 4
34 Anthelmintics Phase 4
35 Antifungal Agents Phase 4
36 Anti-Infective Agents Phase 4
37 Antimalarials Phase 4
38 Antiparasitic Agents Phase 4
39 Antiprotozoal Agents Phase 4
40 Artemether-lumefantrine combination Phase 4
41 Artemisinine Phase 4
42 Artemisinins Phase 4
43 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3
44 Excitatory Amino Acids Phase 4,Phase 2,Phase 3
45 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Psychotropic Drugs Phase 4,Phase 2,Phase 3
47 Tranquilizing Agents Phase 4,Phase 2,Phase 3
48 Anti-Anxiety Agents Phase 4,Phase 2
49 Dermatologic Agents Phase 4,Phase 2
50
Serotonin Phase 4 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 54)
id Name Status NCT ID Phase
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4
3 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4
4 Postoperative Analgesia in Patients With Microvascular Decompression Not yet recruiting NCT03152955 Phase 4
5 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3
6 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3
7 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3
8 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3
9 CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain Terminated NCT00122915 Phase 3
10 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
11 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3
12 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
13 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2
14 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2
15 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Recruiting NCT02473016 Phase 2
16 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2
17 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Recruiting NCT02662972 Phase 1, Phase 2
18 Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer. Recruiting NCT02924675 Phase 2
19 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
20 Civamide Nasal Solution for Postherpetic Neuralgia of the Trigeminal Nerve Terminated NCT01886313 Phase 2
21 Transcranial Stimulation (tDCS) For the Treatment of Neuropathic Facial Pain Terminated NCT01849796 Phase 2
22 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Unknown status NCT02359344 Phase 1
23 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1
24 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1
25 Study of Integrity of Down Inhibitor Bundle at Patients Suffering of Neuropathic Pain Completed NCT01053845 Phase 1
26 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Recruiting NCT02321566 Phase 1
27 Transcranial Magnetic Stimulation for Facial Pain Recruiting NCT02633306 Phase 1
28 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
29 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
30 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598
31 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229
32 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431
33 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967
34 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807
35 Hippocampal Radiation Exposure and Memory Completed NCT00603694
36 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349
37 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
38 Brain as a Therapeutic and Research Target in Trigeminal Neuropathic Pain Completed NCT03003715
39 Somatosensory Investigation of Orofacial Pain Patients Completed NCT02910336
40 fMRI and DTI of Cerebellar Responses to Pain in the Human Trigeminal System Completed NCT01738126
41 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152
42 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810
43 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Recruiting NCT02427074
44 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Recruiting NCT02801630
45 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
46 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906
47 Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy Recruiting NCT01632657
48 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
49 The Efficacy of L-cysteine in Prevention of Cluster Headache Recruiting NCT02310828
50 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Active, not recruiting NCT01761604

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia 29
Sources

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

39
Brain, Testes, Skin, Trigeminal Ganglion, Tongue, Liver, Breast
Sources

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50) (show all 699)
id Title Authors Year
1
Nerve atrophy and a small trigeminal pontine angle in primary trigeminal neuralgia: A morphometric MRI study. ( 28532907 )
2017
2
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. ( 28488638 )
2017
3
Trigeminal neuralgia. ( 28033174 )
2017
4
A retrospective study of neurocombing for the treatment of trigeminal neuralgia without neurovascular compression. ( 28063126 )
2017
5
Nerve Combing for Trigeminal Neuralgia Without Vascular Compression. ( 27875506 )
2017
6
Symptomatic Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors. ( 28468211 )
2017
7
Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia. ( 28520647 )
2017
8
Microvascular decompression is an effective therapy for trigeminal neuralgia due to dolichoectatic basilar artery compression: case reports and literature review. ( 28091827 )
2017
9
An experimental animal model for percutaneous procedures used in trigeminal neuralgia. ( 28397136 )
2017
10
Efficacy and Prognostic Value of Partial Sensory Rhizotomy and Microvascular Decompression for Primary Trigeminal Neuralgia: A Comparative Study. ( 28502974 )
2017
11
The role of radiosurgery in trigeminal neuralgia. ( 28527088 )
2017
12
Trigeminal neuralgia and neuropathy in large sporadic vestibular schwannomas. ( 28084915 )
2017
13
Stereotactic Radiosurgery as Initial Surgical Management for Elderly Patients with Trigeminal Neuralgia. ( 28501876 )
2017
14
Hydrocephalus and trigeminal neuralgia: exploring the association and management options. ( 28421829 )
2017
15
Two times of trigeminal neuralgia resolution following hydrocephalus treatment in a patient with a high-voltage electric shock to his head: a case report and a review of the literature. ( 28429608 )
2017
16
Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression. ( 28424990 )
2017
17
The Study of Calcium, Phosphonium, Magnesium, and Ferrum Concentration in Serum of Patients With Primary Trigeminal Neuralgia. ( 28468201 )
2017
18
Gamma Knife Radiosurgery for Idiopathic Trigeminal Neuralgia; does the status of offending vessels influence on pain control or side effects? ( 28532912 )
2017
19
Computed Tomography in the Diagnosis of Classical Trigeminal Neuralgia. ( 28481804 )
2017
20
Atypical Trigeminal Neuralgia: A Rare Neurological Manifestation of Systemic Lupus Erythematosus. ( 28077839 )
2017
21
Meta-analysis on safety and efficacy of microsurgical and radiosurgical treatment of trigeminal neuralgia. ( 28435111 )
2017
22
Trochlear Schwannoma Presenting with Isolated Trigeminal Neuralgia. ( 28434965 )
2017
23
Trigeminal neuralgia - diagnosis and treatment. ( 28076964 )
2017
24
Clinical analysis and surgical treatment of trigeminal neuralgia caused by vertebrobasilar dolichoectasia: A retrospective study. ( 28392449 )
2017
25
The relationship of dose to nerve volume in predicting pain recurrence after stereotactic radiosurgery in trigeminal neuralgia. ( 28524797 )
2017
26
Frameless stereotactic radiosurgery for the treatment of multiple sclerosis-related trigeminal neuralgia. ( 28454993 )
2017
27
Carotid cavernous fistula after percutaneous balloon compression for trigeminal neuralgia: Endovascular treatment with coils. ( 28458950 )
2017
28
Trigeminal Ganglioneuroma: A rare cause of trigeminal neuralgia caused by cerebello-pontine angle tumor. ( 28043883 )
2016
29
Efficacy of stereotactic gamma knife surgery and microvascular decompression in the treatment of primary trigeminal neuralgia: a retrospective study of 220 cases from a single center. ( 27555796 )
2016
30
Gamma knife radiosurgery for trigeminal neuralgia secondary to benign lesions. ( 27041354 )
2016
31
New clinical and morphological aspects in trigeminal neuralgia. ( 27157289 )
2016
32
Comparing Percutaneous Treatments of Trigeminal Neuralgia: 19 Years of Experience in a Single Centre. ( 27071078 )
2016
33
Narrow Foramen Ovale and Rotundum: A Role in the Etiology of Trigeminal Neuralgia. ( 28005781 )
2016
34
Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia. ( 27885344 )
2016
35
Surgical variation of microvascular decompression for trigeminal neuralgia: A technical note and anatomical study. ( 27625893 )
2016
36
Hydrocephalus: an underrated long-term complication of microvascular decompression for trigeminal neuralgia. A single institute experience. ( 27522357 )
2016
37
Letter to the Editor: Trigeminal neuralgia in patients with multiple sclerosis. ( 27203144 )
2016
38
Symptomatic trigeminal neuralgia and nocturnal thunderclap headache resulting from a carotid paraganglioma. ( 27226004 )
2016
39
Pterygopalatine fossa metastasis with severe trigeminal neuralgia from neuroendocrine carcinoma of the breast. ( 27209445 )
2016
40
Trigeminal Neuralgia Induced by Sour and Spicy Foods: What Is the Underlying Mechanism? A Case Report. ( 27472530 )
2016
41
Central antinociceptive activity of peripherally applied botulinum toxin type A in lab rat model of trigeminal neuralgia. ( 27104119 )
2016
42
Microvascular decompression for trigeminal neuralgia secondary to vertebrobasilar dolichoectasia. Case report, literature review, and pooled case analysis. ( 27445080 )
2016
43
Clinical features and long-term surgical outcomes in 39 patients withtumor-related trigeminal neuralgia compared with 360 patients with idiopathic trigeminal neuralgia. ( 27648861 )
2016
44
Percutaneous trigeminal ganglion radiofrequency thermocoagulation alleviates anxiety and depression disorders in patients with classic trigeminal neuralgia: A cohort study. ( 27930513 )
2016
45
Frameless Stereotactic Radiosurgery, a Feasible Alternative to the Frame-Based Technique for the Treatment of Refractory Trigeminal Neuralgia. ( 27186453 )
2016
46
Percutaneous Glycerol Rhizotomy for Trigeminal Neuralgia Using a Single-Plane, Flat Panel Detector Angiography System: Technical Note. ( 27041633 )
2016
47
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia. ( 27533070 )
2016
48
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
49
A dual concurrent mechanism explains trigeminal neuralgia in patients with multiple sclerosis. ( 27895247 )
2016
50
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK. ( 27093858 )
2016
Sources

Variations for Trigeminal Neuralgia

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Sources

Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
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Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
G-Beta Gamma Signaling 60
Show member pathways
 12.42 BMP2 SCN10A SCN11A SCN3A SCN9A
2
Cardiac conduction 62
Show member pathways
 12.4 SCN10A SCN11A SCN3A SCN9A
3
Neuropathic Pain-Signaling in Dorsal Horn Neurons 60
Show member pathways
 12.21 SCN10A SCN11A SCN3A SCN9A
4
Neuroscience 4
12.09 SCN10A SCN11A SCN9A
5
L1CAM interactions 62
Show member pathways
 11.55 SCN10A SCN11A SCN3A SCN9A
6
Phase 0 - rapid depolarisation 62
Show member pathways
 11.13 SCN10A SCN11A SCN3A SCN9A
7
Interaction between L1 and Ankyrins 62
10.4 SCN10A SCN11A SCN3A SCN9A
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.92 SCN10A SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.8 SCN10A SCN11A SCN3A SCN9A SLC6A4
2 ion transport GO:0006811 9.78 SCN10A SCN11A SCN3A SCN9A
3 response to drug GO:0042493 9.71 MBD1 SCN11A SLC6A4
4 ion transmembrane transport GO:0034220 9.67 SCN11A SCN3A SCN9A
5 regulation of ion transmembrane transport GO:0034765 9.67 SCN10A SCN11A SCN3A SCN9A
6 negative regulation of gene expression GO:0010629 9.63 BMP2 ESR1 MBD1
7 sodium ion transport GO:0006814 9.62 SCN10A SCN11A SCN3A SCN9A
8 response to estradiol GO:0032355 9.61 ESR1 MBD1 SLC6A4
9 sodium ion transmembrane transport GO:0035725 9.56 SCN10A SCN11A SCN3A SCN9A
10 odontogenesis of dentin-containing tooth GO:0042475 9.52 BMP2 SCN10A
11 sensory perception of pain GO:0019233 9.51 SCN10A SCN9A
12 regulation of postsynaptic membrane potential GO:0060078 9.46 SCN10A SCN11A SCN3A SCN9A
13 neuronal action potential GO:0019228 9.26 SCN10A SCN11A SCN3A SCN9A
14 membrane depolarization during action potential GO:0086010 8.92 SCN10A SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.56 SCN10A SCN11A SCN3A SCN9A
2 ion channel activity GO:0005216 9.46 SCN10A SCN11A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.26 SCN10A SCN11A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.92 SCN10A SCN11A SCN3A SCN9A
Sources

Sources for Trigeminal Neuralgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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