MCID: TRG002
MIFTS: 63

Trigeminal Neuralgia malady

Rare diseases, Neuronal diseases categories

Summaries for Trigeminal Neuralgia

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MedlinePlus:34 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to diarrhea and arthritis. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Synaptic transmission ion currents and Interaction between L1 and Ankyrins. The drugs carbamazepine and baclofen and the compounds zoledronic acid and saxitoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are integument and cardiovascular system.

NIH Rare Diseases:43 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:44 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:65 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, or Fothergill\'s disease is a neuropathic... more...

Aliases & Classifications for Trigeminal Neuralgia

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 44NINDS, 12DISEASES, 45Novoseek, 49Orphanet, 24GTR, 34MedlinePlus, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Trigeminal Neuralgia, Aliases & Descriptions:

Name: Trigeminal Neuralgia 10 43 44 12 45 49 24 34 62
Tic Douloureux 43 44 49
Trigeminal Neuralgia Nos 10
 
Trifacial Neuralgia 10
Trifocal Neuralgia 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology10 DOID:12098
ICD9CM29 350.1
MeSH35 D014277
Orphanet49 221091
MESH via Orphanet36 D014277
ICD10 via Orphanet28 G50.0
UMLS via Orphanet63 C0040997
ICD1027 G50.0

Related Diseases for Trigeminal Neuralgia

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Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Symptoms for Trigeminal Neuralgia

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Drugs & Therapeutics for Trigeminal Neuralgia

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Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia24

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

33
Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

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MGI Mouse Phenotypes related to Trigeminal Neuralgia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1SCN10A, JMJD6, CALCA, ESR1, SCN9A
2MP:00053857.7SCN10A, ESR1, CALCA, CRP, JMJD6, BMP2
3MP:00053867.7MBD1, ESR1, SCN3A, SCN9A, SCN10A, CRLF1
4MP:00036317.3SCN10A, MBD1, JMJD6, CRLF1, CALCA, BMP2
5MP:00107687.2SCN3A, JMJD6, CRLF1, CALCA, BMP2, SCN9A

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Second microvascular decompression for trigeminal neuralgia in recurrent cases after microvascular decompression. (25759921)
2015
2
The Occurrence Of HSV Reactivation Suggests A Mechanism Of Trigeminal Neuralgia Surgical Efficacy. (25818891)
2015
3
Altered autonomic nervous system reactivity to pain in trigeminal neuralgia. (25804249)
2015
4
A retrospective study of 72 cases diagnosed with idiopathic trigeminal neuralgia in indian populace. (25810840)
2015
5
Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes. (25270137)
2014
6
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)
2014
7
The long-term outcome predictors of pure microvascular decompression for primary trigeminal neuralgia. (22381868)
2013
8
Tentorial dural arteriovenous fistula manifesting as contralateral trigeminal neuralgia: resolution after transarterial Onyx embolization. (24297368)
2013
9
Dyna-CT-assisted percutaneous microballoon compression for trigeminal neuralgia. (23904451)
2013
10
Salvage treatment of trigeminal neuralgia by occipital nerve stimulation. (24104562)
2013
11
Facial pain induced by isolated lateral pterygoid pyomyositis misdiagnosed as trigeminal neuralgia. (23400971)
2013
12
Non-antiepileptic drugs for trigeminal neuralgia. (24297506)
2013
13
Comparative Evaluation of Surgical Procedures for Trigeminal Neuralgia. (24431878)
2013
14
A Review of Percutaneous Treatments for Trigeminal Neuralgia. (24064481)
2013
15
Repeated percutaneous balloon compression for recurrent trigeminal neuralgia: a long-term study. (22120364)
2012
16
Misoprostol as a therapeutic option for trigeminal neuralgia in patients with multiple sclerosis. (22925476)
2012
17
Stereotactic radiosurgery for trigeminal neuralgia: outcomes and complications. (21815736)
2012
18
Botulinum toxin for trigeminal neuralgia--do we have the evidence? (22990690)
2012
19
Foramen ovale cannulation guided by intra-operative computed tomography with integrated neuronavigation for the treatment of trigeminal neuralgia. (21503836)
2011
20
Efficacy, safety and tolerability of duloxetine in idiopathic trigeminal neuralgia. (22187799)
2011
21
Microvascular decompression for trigeminal neuralgia: visualization of results in a 3D stereoscopic virtual reality environment. (21506062)
2011
22
Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation. (21576839)
2011
23
Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report. (20674409)
2011
24
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
25
Surgical treatment of trigeminal neuralgia. Results from the use of glycerol injection, microvascular decompression, and rhizotomia. (20953805)
2010
26
Assessment and treatment of trigeminal neuralgia. (20852542)
2010
27
Trigeminal Neuralgia in an HIV Patient. (20300421)
2010
28
Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases. (21121797)
2010
29
Lipomatosis of the trigeminal nerve causing trigeminal neuralgia: case report and literature review. (21311625)
2010
30
Image registration strategy of T(1)-weighted and FIESTA MRI sequences in trigeminal neuralgia gamma knife radiosurgery. (20530977)
2010
31
Frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492609)
2010
32
A survey on acupuncture treatment of trigeminal neuralgia. (20397469)
2010
33
Treatment of trigeminal neuralgia with percutaneous glycerol injection into Meckel's cavity: experience in 4012 patients. (20717747)
2010
34
The operative findings in re-do microvascular decompression for recurrent trigeminal neuralgia. (20158349)
2010
35
Salvage gamma knife stereotactic radiosurgery for surgically refractory trigeminal neuralgia. (19084354)
2009
36
Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. (19169626)
2009
37
Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis. (19138330)
2009
38
Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia. (19475723)
2009
39
Altered somatosensory processing in trigeminal neuralgia. (19365802)
2009
40
Peduncular hallucinosis following microvascular decompression for trigeminal neuralgia without direct brainstem injury: case report. (19229466)
2009
41
Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system. (19925024)
2009
42
Trigeminal neuralgia secondary to meningioma of petroclival localization. (19408646)
2009
43
Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. (18958387)
2008
44
Long-term pain response and quality of life in patients with typical trigeminal neuralgia treated with gamma knife stereotactic radiosurgery. (19005382)
2008
45
The Treatment Outcome of Elderly Patients with Idiopathic Trigeminal Neuralgia : Micro-Vascular Decompression versus Gamma Knife Radiosurgery. (19096677)
2008
46
Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia]. (16430179)
2005
47
Symptomatic trigeminal-autonomic cephalalgia evolving to trigeminal neuralgia: report of a case associated with dual pathology. (11903287)
2001
48
Trigeminal neuralgia caused by contralateral cerebellopontine angle meningioma - case report. (11786938)
2001
49
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
50
Long-term outcome after operation for trigeminal neuralgia in patients with posterior fossa tumors. (8622156)
1996

Variations for Trigeminal Neuralgia

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Expression for genes affiliated with Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

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Compounds for genes affiliated with Trigeminal Neuralgia

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Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1zoledronic acid4510.1BMP2, CALCA
2saxitoxin3010.0SCN3A, SCN9A
3lidocaine45 30 1311.9SCN9A, SCN10A
4cerivastatin51 45 30 1312.9BMP2, CRP
5dmsa459.9CRP, CALCA
6zonisamide45 51 1311.9SCN9A, SCN3A
7pamidronate45 51 1311.9CALCA, CRP
8pmma459.8CRP, CALCA
9deoxypyridinoline459.8CALCA, CRP
10teriparatide45 1310.8ESR1, CALCA
11ibandronate45 1310.8CALCA, ESR1
12risedronate45 51 30 61 1313.7CALCA, ESR1
13batrachotoxin309.7SCN3A, SCN9A, SCN10A
14nitroglycerin45 1310.7CALCA, CRP
15qx 314 chloride619.7SCN10A, SCN9A, SCN3A
16tetrodotoxin citrate619.7SCN10A, SCN9A, SCN3A
17fluvastatin45 51 30 1312.7CRP, BMP2
18phrixotoxin 3619.7SCN10A, SCN9A, SCN3A
19veratridine45 61 3011.7SCN3A, SCN9A, SCN10A
2025-hydroxyvitamin d459.7CALCA, CRP
21alendronate45 51 1311.5CALCA, BMP2, ESR1
22progestins459.5ESR1, PGRMC1
23raloxifene45 51 30 1312.5ESR1, BMP2, CALCA
24methacholine45 51 1311.4CALCA, CRP
25cyclophosphamide45 51 1311.4ESR1, BMP2, CRP
26vitamin d459.4CALCA, BMP2, ESR1
27tibolone459.3ESR1, CALCA, CRP
28tetrodotoxin45 61 3011.3SCN10A, SCN9A, SCN3A, CALCA
29prostaglandin f2alpha459.2CRP, CALCA
30estrogen458.9PGRMC1, ESR1, BMP2, CALCA
31vegf458.9ESR1, BMP2, CALCA, CRP
32testosterone45 61 26 1311.7PGRMC1, ESR1, BMP2, CALCA, CRP

GO Terms for genes affiliated with Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.0SCN3A, SCN9A, SCN10A
2extracellular spaceGO:00056159.0CRLF1, CRP, CALCA, BMP2

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart rateGO:00020279.7CALCA, SCN10A
2positive regulation of ossificationGO:00457789.5CALCA, BMP2
3sodium ion transportGO:00068149.4SCN3A, SCN9A, SCN10A
4sodium ion transmembrane transportGO:00357259.3SCN3A, SCN9A, SCN10A
5inflammatory responseGO:00069548.7SCN9A, BMP2, CALCA, CRP

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.5PGRMC1, ESR1
2voltage-gated sodium channel activityGO:00052489.3SCN3A, SCN9A, SCN10A
3identical protein bindingGO:00428027.8JMJD6, CALCA, ESR1, BNIPL
4protein bindingGO:00055156.3BNIPL, PGRMC1, ESR1, BMP2, CALCA, CRP

Products for genes affiliated with Trigeminal Neuralgia

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Sources for Trigeminal Neuralgia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet