Trigeminal Neuralgia malady

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OMIM52 190400 Disease Ontology11 DOID:12098 ICD1030 G50.0 ICD9CM32 350.1 MeSH39 D014277 SNOMED-CT62 155066002, 193090007, 31681005 322769008, more

Orphanet54 ORPHA221091 MESH via Orphanet40 D014277 UMLS via Orphanet69 C0040997 ICD10 via Orphanet31 G50.0 UMLS68 C0040997

NINDS:⁴⁹ Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to glossopharyngeal neuralgia and hemifacial atrophy, progressive, and has symptoms including back pain, back pain and facial pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways are Neuroscience and Cardiac conduction. The drugs carbamazepine and baclofen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological.

NIH Rare Diseases:⁴⁸ Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain lasts a few seconds to a few minutes, and usually on only one side of the face. it can also cause muscle spasms in the face the same time as the pain. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches. last updated: 2/17/2016

MedlinePlus:³⁸ Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

Wikipedia:⁷¹ Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM:⁵² 190400

Symptoms by clinical synopsis from OMIM:

190400

Clinical features from OMIM:

190400

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-84	9.7	MBD1, SCN11A, SLC6A4

MGI Mouse Phenotypes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	8.0	CRLF1, ESR1, MBD1, SCN10A, SCN11A, SCN3A
2	nervous system	MP:0003631	6.9	BMP2, CRLF1, ESR1, MBD1, SCN10A, SCN11A

Search GEO for disease gene expression data for Trigeminal Neuralgia.