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MCID: TRG002
MIFTS: 60

Trigeminal Neuralgia

Categories: Rare diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trigeminal Neuralgia

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MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 53 12 72 49 50 55 28 51 40 41 14 69
Tic Douloureux 53 49 50
Trigeminal Neuralgia [no Drugs Here] 12
Trigeminal Neuralgia Nos 12
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant form


HPO:

31
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 55  
Rare neurological diseases


External Ids:

OMIM 53 190400
Disease Ontology 12 DOID:12098
ICD10 32 G50.0
ICD9CM 34 350.1
MeSH 41 D014277
Orphanet 55 ORPHA221091
MESH via Orphanet 42 D014277
UMLS via Orphanet 70 C0040997
ICD10 via Orphanet 33 G50.0
MedGen 39 C0040997
SNOMED-CT via HPO 65 263681008
UMLS 69 C0040997
Sources

Summaries for Trigeminal Neuralgia

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NINDS : 50 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to burning mouth syndrome and postpartum depression, and has symptoms including sleeplessness, vertigo/dizziness and orofacial pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Cardiac conduction. The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

NIH Rare Diseases : 49 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theĀ face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches. Last updated: 2/17/2016

MedlinePlus : 40 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 burning mouth syndrome 30.3 SCN9A TRPV1
2 postpartum depression 30.0 ESR1 SLC6A4
3 neuroma 29.9 SCN10A TRPV1
4 migraine with or without aura 1 29.9 ESR1 SLC6A4 TRPV1
5 paine syndrome 29.6 SCN10A SCN11A SCN9A TRPV1
6 glossopharyngeal neuralgia 11.6
7 headache 11.5
8 paroxysmal hemicrania 11.5
9 sunct headache 11.4
10 hemifacial atrophy, progressive 11.1
11 epidermoid brain cyst 11.1
12 trigeminal trophic syndrome 11.1
13 episodic pain syndrome, familial, 1 10.6
14 hemifacial spasm 10.5
15 multiple sclerosis 10.5
16 erythromelalgia 10.4 SCN10A SCN9A
17 mononeuritis of lower limb 10.3 SCN10A TRPV1
18 lesion of sciatic nerve 10.3 SCN10A TRPV1
19 retinitis pigmentosa 20 10.3 ESR1 SLC6A4
20 sciatic neuropathy 10.3 SCN10A TRPV1
21 somatoform disorder 10.3 SCN9A TRPV1
22 meningioma, familial 10.2
23 arteriovenous malformation 10.2
24 bone resorption disease 10.2 ESR1 TRPV1
25 bone remodeling disease 10.2 ESR1 TRPV1
26 dyspepsia 10.2 SLC6A4 TRPV1
27 cranial nerve disease 10.1 MBD1 TRPV1
28 female reproductive system disease 10.1 ESR1 TRPV1
29 dental pulp disease 10.1 SCN11A TRPV1
30 hydrocephalus 10.1
31 arachnoiditis 10.1
32 cerebellopontine angle tumor 10.1
33 persistent idiopathic facial pain 10.1
34 peripheral nervous system disease 10.1 SCN9A TRPV1
35 irritable bowel syndrome 10.1 SLC6A4 TRPV1
36 sodium channelopathy-related small fiber neuropathy 10.0 SCN10A SCN11A SCN9A
37 erythermalgia, primary 10.0 SCN10A SCN11A SCN9A
38 epidermoid cysts 10.0
39 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
40 arteriovenous fistula 10.0
41 burns 10.0
42 neuropathy 10.0
43 arachnoid cysts 10.0
44 cavernous malformation 10.0
45 postherpetic neuralgia 10.0
46 indifference to pain, congenital, autosomal recessive 10.0 SCN10A SCN11A SCN9A
47 facial spasm 9.9
48 lipomatosis, multiple 9.9
49 temporal arteritis 9.9
50 aging 9.9

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Symptoms via clinical synopsis from OMIM:

53
Neuro:
trigeminal neuralgia


Clinical features from OMIM:

190400

Human phenotypes related to Trigeminal Neuralgia:

31
# Description HPO Frequency HPO Source Accession
1 trigeminal neuralgia 31 HP:0100661

UMLS symptoms related to Trigeminal Neuralgia:


sleeplessness, vertigo/dizziness, orofacial pain, atypical facial pain, chronic pain, tremor, syncope, seizures, sciatica, pain, neuralgia, headache, facial pain, back pain

GenomeRNAi Phenotypes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.53 MBD1 SLC6A4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 SCN11A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.53 MBD1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.53 MBD1 SCN11A SLC6A4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.53 SCN11A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.53 SCN11A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.53 SLC6A4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.53 MBD1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 SLC6A4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 SLC6A4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.53 MBD1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 SLC6A4
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.53 MBD1

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 CRLF1 ESR1 MBD1 SCN10A SCN11A SCN3A
2 integument MP:0010771 9.43 ESR1 SCN10A SCN11A SCN9A SLC6A4 TRPV1
3 nervous system MP:0003631 9.23 CRLF1 ESR1 MBD1 SCN10A SCN11A SCN9A
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Artemether Approved Phase 4 71963-77-4 68911 119380
5
Lumefantrine Approved Phase 4 82186-77-4 6437380
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7
Acetylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2 51-84-3 187
8
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3 298-46-4 2554
9
Oxcarbazepine Approved Phase 4 28721-07-5 34312
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Ondansetron Approved Phase 4 99614-02-5 4595
12
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
13
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
14 Analgesics Phase 4,Phase 2,Phase 3
15 Anesthetics Phase 4,Phase 2,Phase 3
16 Anesthetics, Local Phase 4,Phase 2,Phase 3
17 Antiemetics Phase 4
18 Anti-Inflammatory Agents Phase 4
19 Antineoplastic Agents, Hormonal Phase 4
20 Autonomic Agents Phase 4
21 BB 1101 Phase 4
22 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
23 Dexamethasone acetate Phase 4 1177-87-3
24 Gastrointestinal Agents Phase 4
25 glucocorticoids Phase 4
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4
28 Hormones Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Immunosuppressive Agents Phase 4
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
32
protease inhibitors Phase 4
33 triamcinolone acetonide Phase 4
34 Triamcinolone diacetate Phase 4
35 Triamcinolone hexacetonide Phase 4
36 Anthelmintics Phase 4
37 Antifungal Agents Phase 4
38 Anti-Infective Agents Phase 4
39 Antimalarials Phase 4
40 Antiparasitic Agents Phase 4
41 Antiprotozoal Agents Phase 4
42 Artemether-lumefantrine combination Phase 4
43 Artemisinine Phase 4
44 Artemisinins Phase 4
45 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2
46 Botulinum Toxins Phase 4,Phase 3,Phase 1,Phase 2
47 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2
48 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2
49 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2
50 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show all 47)

# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
3 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4 COA566
4 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
5 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
6 Postoperative Analgesia in Patients With Microvascular Decompression Not yet recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
11 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
12 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
13 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
14 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
15 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
16 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
17 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
18 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
19 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Recruiting NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
20 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
21 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
22 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
23 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
24 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
25 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Unknown status NCT02427074
26 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
27 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
28 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
29 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406
30 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604
31 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 lamotrigine;Placebo
32 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Lidocaine
33 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 L-baclofen
34 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807
35 Hippocampal Radiation Exposure and Memory Completed NCT00603694
36 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349 Botulinum Toxin Type A
37 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
38 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Nerve block
39 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810
40 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Recruiting NCT02801630
41 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
42 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906
43 Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy Recruiting NCT01632657 Sumatriptan;Placebo
44 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
45 RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT Enrolling by invitation NCT01885299
46 FMRI Assessment After Radiofrequency in Trigeminal Neuralgia Not yet recruiting NCT03305289
47 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: trigeminal neuralgia

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Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 28
Sources

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

38
Brain, Testes, Skin, Trigeminal Ganglion, Liver, Cortex, Tongue
Sources

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50) (show all 739)
# Title Authors Year
1
Dosimetric comparison of sector-blocked and non-sector-blocked Gamma Knife Perfexion treatment plans for trigeminal neuralgia. ( 29395459 )
2018
2
Editors' note: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378922 )
2018
3
Early Stereotactic Radiosurgery for Medically Refractory Trigeminal Neuralgia. ( 29371169 )
2018
4
Therapeutic and Analgesic Efficacy of Laser in Conjunction With Pharmaceutical Therapy for Trigeminal Neuralgia. ( 29399314 )
2018
5
The timing of stereotactic radiosurgery for medically refractory trigeminal neuralgia: the evidence from diffusion tractography images. ( 29397449 )
2018
6
Preoperative evaluation of neurovascular relationship in trigeminal neuralgia by three-dimensional fast low angle shot (3D-FLASH) and three-dimensional constructive interference in steady-state (3D-CISS) MRI sequence. ( 29388798 )
2018
7
Characterizing Treatment Utilization Patterns for Trigeminal Neuralgia in the United States. ( 29443722 )
2018
8
Diffusion Tensor Imaging of Axonal and Myelin Changes in Classical Trigeminal Neuralgia. ( 29410338 )
2018
9
Awake Microvascular Decompression for Trigeminal Neuralgia: Concept and Initial Results. ( 29452326 )
2018
10
Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia. ( 29369456 )
2018
11
Trigeminal Nerve Compression Without Trigeminal Neuralgia: Intraoperative vs Imaging Evidence. ( 29425330 )
2018
12
Author response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378924 )
2018
13
Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia. ( 29430195 )
2018
14
Reader response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378923 )
2018
15
Pain-Free outcomes and Durability of Surgical Intervention for Trigeminal Neuralgia: A Comparison of Gamma Knife and Microvascular Decompression. ( 29382615 )
2018
16
Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia. ( 29424256 )
2018
17
Comparative efficacy and acceptability of antiepileptic drugs for classical trigeminal neuralgia: a Bayesian network meta-analysis protocol. ( 29358420 )
2018
18
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update. ( 28827979 )
2017
19
Altered brain structure and function associated with sensory and affective components of classic trigeminal neuralgia. ( 28520647 )
2017
20
Effects of Pulsed Versus Conventional Versus Combined Radiofrequency for the Treatment of Trigeminal Neuralgia: A Prospective Study. ( 28934792 )
2017
21
A retrospective study of neurocombing for the treatment of trigeminal neuralgia without neurovascular compression. ( 28063126 )
2017
22
Factors determining the outcome in trigeminal neuralgia treated with percutaneous balloon compression. ( 28765027 )
2017
23
Microvascular decompression for trigeminal neuralgia using a novel fenestrated clip and tentorial flap technique. ( 28754638 )
2017
24
Nerve Combing for Trigeminal Neuralgia Without Vascular Compression. ( 27875506 )
2017
25
Clinical analysis and surgical treatment of trigeminal neuralgia caused by vertebrobasilar dolichoectasia: A retrospective study. ( 28392449 )
2017
26
Long-term outcomes of microvascular decompression and Gamma Knife surgery for trigeminal neuralgia: a retrospective comparison study. ( 28920139 )
2017
27
Pharmacological treatment of trigeminal neuralgia. ( 28829200 )
2017
28
Hydrocephalus and trigeminal neuralgia: exploring the association and management options. ( 28421829 )
2017
29
A rare presentation of trigeminal neuralgia in lateral medullary syndrome. ( 28488638 )
2017
30
Long-term outcomes of microvascular decompression and Gamma Knife surgery for trigeminal neuralgia: a retrospective comparison study. ( 28905114 )
2017
31
Computed Tomography in the Diagnosis of Classical Trigeminal Neuralgia. ( 28481804 )
2017
32
Gamma Knife Radiosurgery for Idiopathic Trigeminal Neuralgia; does the status of offending vessels influence on pain control or side effects? ( 28532912 )
2017
33
Trigeminal neuralgia and neuropathy in large sporadic vestibular schwannomas. ( 28084915 )
2017
34
Long-term outcome of percutaneous balloon compression for trigeminal neuralgia patients elder than 80 years: A STROBE-compliant article. ( 28953684 )
2017
35
Microvascular decompression is an effective therapy for trigeminal neuralgia due to dolichoectatic basilar artery compression: case reports and literature review. ( 28091827 )
2017
36
Neuromodulation and Devices in Trigeminal Neuralgia. ( 28905370 )
2017
37
Stimulus-sensitive myoclonus with trigeminal neuralgia. ( 28906076 )
2017
38
Trigeminal Neuralgia. ( 28375911 )
2017
39
Efficacy and Prognostic Value of Partial Sensory Rhizotomy and Microvascular Decompression for Primary Trigeminal Neuralgia: A Comparative Study. ( 28502974 )
2017
40
Meta-analysis on safety and efficacy of microsurgical and radiosurgical treatment of trigeminal neuralgia. ( 28435111 )
2017
41
Stereotactic Radiosurgery as Initial Surgical Management for Elderly Patients with Trigeminal Neuralgia. ( 28501876 )
2017
42
Affective Circuitry Alterations in Patients with Trigeminal Neuralgia. ( 28928638 )
2017
43
Imaging evaluation of trigeminal neuralgia. ( 29354310 )
2017
44
Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression. ( 28424990 )
2017
45
Two times of trigeminal neuralgia resolution following hydrocephalus treatment in a patient with a high-voltage electric shock to his head: a case report and a review of the literature. ( 28429608 )
2017
46
An experimental animal model for percutaneous procedures used in trigeminal neuralgia. ( 28397136 )
2017
47
Long-term efficacy of nerve combing for the patients with trigeminal neuralgia who failed prior microvascular decompression. ( 28943423 )
2017
48
Atypical Trigeminal Neuralgia: A Rare Neurological Manifestation of Systemic Lupus Erythematosus. ( 28077839 )
2017
49
Trigeminal neuralgia. ( 28033174 )
2017
50
Single-dose botulinum toxin type a compared with repeated-dose for treatment of trigeminal neuralgia: a pilot study. ( 28799056 )
2017
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Variations for Trigeminal Neuralgia

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Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
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Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G-Beta Gamma Signaling 60
Show member pathways
 12.54 SCN10A SCN11A SCN3A SCN9A
2
Cardiac conduction 62
Show member pathways
 12.35 SCN10A SCN11A SCN3A SCN9A
3
Neuropathic Pain-Signaling in Dorsal Horn Neurons 60
Show member pathways
 12.15 SCN10A SCN11A SCN3A SCN9A
4
L1CAM interactions 62
Show member pathways
 11.55 SCN10A SCN11A SCN3A SCN9A
5
Phase 0 - rapid depolarisation 62
Show member pathways
 11.13 SCN10A SCN11A SCN3A SCN9A
6
Interaction between L1 and Ankyrins 62
10.4 SCN10A SCN11A SCN3A SCN9A
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.92 SCN10A SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.99 SCN10A SCN11A SCN3A SCN9A SLC6A4 TRPV1
2 ion transport GO:0006811 9.88 SCN10A SCN11A SCN3A SCN9A TRPV1
3 transmembrane transport GO:0055085 9.8 SCN10A SCN11A SCN3A SCN9A SLC6A4 TRPV1
4 ion transmembrane transport GO:0034220 9.76 SCN11A SCN3A SCN9A TRPV1
5 regulation of ion transmembrane transport GO:0034765 9.71 SCN10A SCN11A SCN3A SCN9A
6 sodium ion transport GO:0006814 9.67 SCN10A SCN11A SCN3A SCN9A
7 sensory perception of pain GO:0019233 9.61 SCN10A SCN9A TRPV1
8 sodium ion transmembrane transport GO:0035725 9.56 SCN10A SCN11A SCN3A SCN9A
9 interleukin-12-mediated signaling pathway GO:0035722 9.52 CRLF1 GSTO1
10 behavioral response to pain GO:0048266 9.49 SCN9A TRPV1
11 regulation of postsynaptic membrane potential GO:0060078 9.46 SCN10A SCN11A SCN3A SCN9A
12 neuronal action potential GO:0019228 9.26 SCN10A SCN11A SCN3A SCN9A
13 membrane depolarization during action potential GO:0086010 8.92 SCN10A SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.56 SCN10A SCN11A SCN3A SCN9A
2 ion channel activity GO:0005216 9.55 SCN10A SCN11A SCN3A SCN9A TRPV1
3 sodium channel activity GO:0005272 9.26 SCN10A SCN11A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.92 SCN10A SCN11A SCN3A SCN9A
Sources

Sources for Trigeminal Neuralgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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