MCID: TRG002
MIFTS: 56

Trigeminal Neuralgia malady

Rare diseases, Neuronal diseases categories

Summaries for Trigeminal Neuralgia

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MedlinePlus:32 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to diarrhea and arthritis. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Synaptic transmission ion currents and Interaction between L1 and Ankyrins. The drugs baclofen and carbamazepine and the compounds zoledronic acid and saxitoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are integument and cardiovascular system.

NIH Rare Diseases:41 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:42 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:63 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, or Fothergill\'s disease is a neuropathic... more...

Aliases & Classifications for Trigeminal Neuralgia

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Trigeminal Neuralgia, Aliases & Descriptions:

Name: Trigeminal Neuralgia 9 41 42 11 43 47 22 32 60
Tic Douloureux 41 42 47
Trigeminal Neuralgia Nos 9
 
Trifacial Neuralgia 9
Trifocal Neuralgia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:12098
ICD9CM27 350.1
MeSH33 D014277
Orphanet47 221091
MESH via Orphanet34 D014277
ICD10 via Orphanet26 G50.0
UMLS via Orphanet61 C0040997
ICD1025 G50.0

Related Diseases for Trigeminal Neuralgia

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Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Symptoms for Trigeminal Neuralgia

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Drugs & Therapeutics for Trigeminal Neuralgia

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Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia22

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

31
Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

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MGI Mouse Phenotypes related to Trigeminal Neuralgia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1JMJD6, CALCA, ESR1, SCN9A, SCN10A
2MP:00053857.7SCN10A, ESR1, BMP2, CALCA, CRP, JMJD6
3MP:00053867.7SCN10A, SCN9A, SCN3A, ESR1, CALCA, CRLF1
4MP:00036317.3MBD1, SCN10A, SCN9A, ESR1, BMP2, CALCA
5MP:00107687.2SCN9A, SCN3A, ESR1, BMP2, CALCA, CRLF1

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Second microvascular decompression for trigeminal neuralgia in recurrent cases after microvascular decompression. (25759921)
2015
2
The Occurrence Of HSV Reactivation Suggests A Mechanism Of Trigeminal Neuralgia Surgical Efficacy. (25818891)
2015
3
Altered autonomic nervous system reactivity to pain in trigeminal neuralgia. (25804249)
2015
4
A retrospective study of 72 cases diagnosed with idiopathic trigeminal neuralgia in indian populace. (25810840)
2015
5
Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes. (25270137)
2014
6
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)
2014
7
The long-term outcome predictors of pure microvascular decompression for primary trigeminal neuralgia. (22381868)
2013
8
Tentorial dural arteriovenous fistula manifesting as contralateral trigeminal neuralgia: resolution after transarterial Onyx embolization. (24297368)
2013
9
Dyna-CT-assisted percutaneous microballoon compression for trigeminal neuralgia. (23904451)
2013
10
Salvage treatment of trigeminal neuralgia by occipital nerve stimulation. (24104562)
2013
11
Facial pain induced by isolated lateral pterygoid pyomyositis misdiagnosed as trigeminal neuralgia. (23400971)
2013
12
Non-antiepileptic drugs for trigeminal neuralgia. (24297506)
2013
13
Comparative Evaluation of Surgical Procedures for Trigeminal Neuralgia. (24431878)
2013
14
A Review of Percutaneous Treatments for Trigeminal Neuralgia. (24064481)
2013
15
Repeated percutaneous balloon compression for recurrent trigeminal neuralgia: a long-term study. (22120364)
2012
16
Misoprostol as a therapeutic option for trigeminal neuralgia in patients with multiple sclerosis. (22925476)
2012
17
Stereotactic radiosurgery for trigeminal neuralgia: outcomes and complications. (21815736)
2012
18
Botulinum toxin for trigeminal neuralgia--do we have the evidence? (22990690)
2012
19
Foramen ovale cannulation guided by intra-operative computed tomography with integrated neuronavigation for the treatment of trigeminal neuralgia. (21503836)
2011
20
Efficacy, safety and tolerability of duloxetine in idiopathic trigeminal neuralgia. (22187799)
2011
21
Microvascular decompression for trigeminal neuralgia: visualization of results in a 3D stereoscopic virtual reality environment. (21506062)
2011
22
Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation. (21576839)
2011
23
Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report. (20674409)
2011
24
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
25
Surgical treatment of trigeminal neuralgia. Results from the use of glycerol injection, microvascular decompression, and rhizotomia. (20953805)
2010
26
Assessment and treatment of trigeminal neuralgia. (20852542)
2010
27
Trigeminal Neuralgia in an HIV Patient. (20300421)
2010
28
Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases. (21121797)
2010
29
Lipomatosis of the trigeminal nerve causing trigeminal neuralgia: case report and literature review. (21311625)
2010
30
Image registration strategy of T(1)-weighted and FIESTA MRI sequences in trigeminal neuralgia gamma knife radiosurgery. (20530977)
2010
31
Frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492609)
2010
32
A survey on acupuncture treatment of trigeminal neuralgia. (20397469)
2010
33
Treatment of trigeminal neuralgia with percutaneous glycerol injection into Meckel's cavity: experience in 4012 patients. (20717747)
2010
34
The operative findings in re-do microvascular decompression for recurrent trigeminal neuralgia. (20158349)
2010
35
Salvage gamma knife stereotactic radiosurgery for surgically refractory trigeminal neuralgia. (19084354)
2009
36
Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. (19169626)
2009
37
Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis. (19138330)
2009
38
Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia. (19475723)
2009
39
Altered somatosensory processing in trigeminal neuralgia. (19365802)
2009
40
Peduncular hallucinosis following microvascular decompression for trigeminal neuralgia without direct brainstem injury: case report. (19229466)
2009
41
Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system. (19925024)
2009
42
Trigeminal neuralgia secondary to meningioma of petroclival localization. (19408646)
2009
43
Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. (18958387)
2008
44
Long-term pain response and quality of life in patients with typical trigeminal neuralgia treated with gamma knife stereotactic radiosurgery. (19005382)
2008
45
The Treatment Outcome of Elderly Patients with Idiopathic Trigeminal Neuralgia : Micro-Vascular Decompression versus Gamma Knife Radiosurgery. (19096677)
2008
46
Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia]. (16430179)
2005
47
Symptomatic trigeminal-autonomic cephalalgia evolving to trigeminal neuralgia: report of a case associated with dual pathology. (11903287)
2001
48
Trigeminal neuralgia caused by contralateral cerebellopontine angle meningioma - case report. (11786938)
2001
49
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
50
Long-term outcome after operation for trigeminal neuralgia in patients with posterior fossa tumors. (8622156)
1996

Variations for Trigeminal Neuralgia

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Expression for genes affiliated with Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

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Compounds for genes affiliated with Trigeminal Neuralgia

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Compounds related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1zoledronic acid4310.1BMP2, CALCA
2saxitoxin2810.0SCN3A, SCN9A
3lidocaine43 28 1211.9SCN9A, SCN10A
4cerivastatin49 43 28 1212.9BMP2, CRP
5dmsa439.9CRP, CALCA
6zonisamide43 49 1211.9SCN9A, SCN3A
7pamidronate43 49 1211.9CALCA, CRP
8pmma439.8CRP, CALCA
9deoxypyridinoline439.8CALCA, CRP
10teriparatide43 1210.8ESR1, CALCA
11ibandronate43 1210.8CALCA, ESR1
12risedronate43 49 28 59 1213.7CALCA, ESR1
13batrachotoxin289.7SCN3A, SCN9A, SCN10A
14nitroglycerin43 1210.7CALCA, CRP
15qx 314 chloride599.7SCN10A, SCN9A, SCN3A
16tetrodotoxin citrate599.7SCN10A, SCN9A, SCN3A
17fluvastatin43 49 28 1212.7CRP, BMP2
18phrixotoxin 3599.7SCN10A, SCN9A, SCN3A
19veratridine43 59 2811.7SCN3A, SCN9A, SCN10A
2025-hydroxyvitamin d439.7CALCA, CRP
21alendronate43 49 1211.5CALCA, BMP2, ESR1
22progestins439.5ESR1, PGRMC1
23raloxifene43 49 28 1212.5ESR1, BMP2, CALCA
24methacholine43 49 1211.4CALCA, CRP
25cyclophosphamide43 49 1211.4ESR1, BMP2, CRP
26vitamin d439.4CALCA, BMP2, ESR1
27tibolone439.3ESR1, CALCA, CRP
28tetrodotoxin43 59 2811.3SCN10A, SCN9A, SCN3A, CALCA
29prostaglandin f2alpha439.2CRP, CALCA
30estrogen438.9PGRMC1, ESR1, BMP2, CALCA
31vegf438.9ESR1, BMP2, CALCA, CRP
32testosterone43 59 24 1211.7PGRMC1, ESR1, BMP2, CALCA, CRP

GO Terms for genes affiliated with Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00015189.0SCN3A, SCN9A, SCN10A
2extracellular spaceGO:00056159.0CRLF1, CRP, CALCA, BMP2

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart rateGO:00020279.7CALCA, SCN10A
2positive regulation of ossificationGO:00457789.5CALCA, BMP2
3sodium ion transportGO:00068149.4SCN3A, SCN9A, SCN10A
4sodium ion transmembrane transportGO:00357259.3SCN3A, SCN9A, SCN10A
5inflammatory responseGO:00069548.7SCN9A, BMP2, CALCA, CRP

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.5ESR1, PGRMC1
2voltage-gated sodium channel activityGO:00052489.3SCN3A, SCN9A, SCN10A
3identical protein bindingGO:00428027.8BNIPL, ESR1, CALCA, JMJD6
4protein bindingGO:00055156.3BNIPL, PGRMC1, ESR1, BMP2, CALCA, CRP

Products for genes affiliated with Trigeminal Neuralgia

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Sources for Trigeminal Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet