MCID: TRG002
MIFTS: 63

Trigeminal Neuralgia malady

Neuronal diseases category

Summaries for Trigeminal Neuralgia

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards: Trigeminal Neuralgia, also known as tic douloureux, is related to migraine and neuroma. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Sodium channels and transporters: inward current and G-Beta Gamma Signaling. The drugs baclofen and carbamazepine and the compounds saxitoxin and Lacosamide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are cardiovascular system and behavior/neurological.

NIH Rare Diseases:42 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:43 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:63 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, or Fothergill\'s disease is a neuropathic... more...

Description from OMIM:46 190400

Aliases & Classifications for Trigeminal Neuralgia

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

trigeminal neuralgia 8 42 43 10 44 48 46 33 60 22
tic douloureux 42 43 48
trigeminal neuralgia nos 8
trifacial neuralgia 8
trifocal neuralgia 8


External Ids:

Disease Ontology8 DOID:12098
MeSH34 D014277
ICD9CM27 350.1
OMIM46 190400
MESH via Orphanet35 D014277
ICD10 via Orphanet26 G50.0
SNOMED-CT via Orphanet57 31681005
UMLS via Orphanet61 C0040997
ICD1025 G50.0

Related Diseases for Trigeminal Neuralgia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Clinical Features for Trigeminal Neuralgia

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46OMIM
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Clinical features from OMIM:

190400

Clinical synopsis from OMIM:

190400

Drugs & Therapeutics for Trigeminal Neuralgia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Trigeminal Neuralgia

Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Search CenterWatch for Trigeminal Neuralgia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trigeminal Neuralgia

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22GTR
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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia22

Anatomical Context for Trigeminal Neuralgia

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32MalaCards
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MalaCards organs/tissues related to Trigeminal Neuralgia:

32
Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Trigeminal Neuralgia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CALCA, IFT122, SCN10A, BMP2, CRP, EMILIN1
2MP:00053867.5CALCA, IFT122, MBD1, SCN10A, SCN3A, SCN9A
3MP:00036316.9ESR1, JMJD6, CALCA, IFT122, MBD1, SCN10A

Publications for Trigeminal Neuralgia

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50PubMed
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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Glycerol rhizotomy via a retrosigmoid approach as an alternative treatment for trigeminal neuralgia. (24161889)
2013
2
Trigeminal neuralgia due to Dandy-Walker syndrome. (23851831)
2013
3
Microvascular decompression for classic trigeminal neuralgia: determination of minimum clinically important difference in pain improvement for patient reported outcomes. (23328688)
2013
4
Constant face pain in typical trigeminal neuralgia and response to I^ knife radiosurgery. (23343637)
2013
5
Outcomes After Microvascular Decompression for Patients with Trigeminal Neuralgia and Suspected Multiple Sclerosis. (24056218)
2013
6
Resolution of trigeminal neuralgia following minimal coil embolization of a primitive trigeminal artery associated with a cerebellar arteriovenous malformation. (23686632)
2013
7
Endoscopic Vascular Decompression for the Treatment of Trigeminal Neuralgia: Clinical Outcomes and Technical Note. (24140999)
2013
8
The role of the cerebellopontine angle cistern area and trigeminal nerve length in the pathogenesis of trigeminal neuralgia: a prospective case-control study. (23224512)
2013
9
Botulinum toxin for trigeminal neuralgia--do we have the evidence? (22990690)
2012
10
Percutaneous balloon compression for the treatment of trigeminal neuralgia in patients with multiple sclerosis. Analysis of the potentially prognostic factors. (22350443)
2012
11
Trigeminal neuralgia: a retrospective study of 188 Thai cases. (21726275)
2012
12
Intractable pain from trigeminal neuralgia. (22585202)
2012
13
Foramen ovale cannulation guided by intra-operative computed tomography with integrated neuronavigation for the treatment of trigeminal neuralgia. (21503836)
2011
14
Identification of a persistent primitive trigeminal artery following the transposition technique for trigeminal neuralgia: a case report. (22059208)
2011
15
Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis. (21936587)
2011
16
Trigeminal neuralgia due to neurovascular compression: high-spatial-resolution diffusion-tensor imaging reveals microstructural neural changes. (21062923)
2011
17
Current gamma knife treatment for ophthalmic branch of primary trigeminal neuralgia. (22553625)
2011
18
Application of a new method of revealing foramen ovale under X-ray in radiofrequency ablation in the treatment of trigeminal neuralgia. (21501054)
2011
19
Percutaneous glycerol rhizotomy for trigeminal neuralgia: safety and efficacy of repeat procedures. (21545328)
2011
20
Visualization of vascular compression of the trigeminal nerve with high-resolution 3T MRI: a prospective study comparing preoperative imaging analysis to surgical findings in 40 consecutive patients who underwent microvascular decompression for trigeminal neuralgia. (21346659)
2011
21
Trigeminal neuralgia: the diagnosis and management of this excruciating and poorly understood facial pain. (21493636)
2011
22
Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study. (21960648)
2011
23
Surgery for trigeminal neuralgia? (21232859)
2011
24
Frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492609)
2010
25
A case of trigeminal neuralgia complicated by ipsilateral temporal arteritis. (20063018)
2010
26
Gamma Knife surgery for recurrent or residual trigeminal neuralgia after a failed initial procedure. (21121799)
2010
27
John Murray Carnochan (1817-1887): the first description of successful surgery for trigeminal neuralgia. (19480543)
2010
28
LINAC frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492593)
2010
29
Predicting the outcome of microvascular decompression for trigeminal neuralgia using magnetic resonance tomographic angiography. (19490372)
2010
30
Sluder's neuralgia: a trigeminal autonomic cephalalgia? (19614698)
2010
31
Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing. (20186560)
2010
32
Surgical treatment of trigeminal neuralgia: a history of early strides toward curing a "cancerous acrimony". (20871443)
2010
33
Preoperative magnetic resonance imaging in Type 2 trigeminal neuralgia. (20113162)
2010
34
Developmental venous anomaly causing trigeminal neuralgia. (21049204)
2010
35
Trigeminal neuralgia: the role of magnetic resonance imaging. (18938001)
2009
36
The treatment of first division idiopathic trigeminal neuralgia with radiofrequency thermocoagulation of the peripheral branches compared to conventional radiofrequency. (19683927)
2009
37
Gamma knife radiosurgery in patients with trigeminal neuralgia: quality of life, outcomes, and complications. (18995955)
2009
38
Trigeminal neuralgia secondary to epidermoid cyst at the cerebellopontine angle: case report and brief overview. (19184299)
2009
39
Atypical trigeminal neuralgia of the mental nerve: a case study. (19241795)
2009
40
Historical characterization of trigeminal neuralgia. (19487899)
2009
41
Trigeminal neuralgia: outcomes after gamma knife radiosurgery. (19294893)
2009
42
Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. (18958387)
2008
43
Comparison of the results of 2 targeting methods in Gamma Knife surgery for trigeminal neuralgia. (19123907)
2008
44
Botulinum toxin A for the treatment of greater occipital neuralgia and trigeminal neuralgia: a case report with pathophysiological considerations. (16472343)
2006
45
Cavernous malformation of the trigeminal nerve manifesting with trigeminal neuralgia: case report. (15730590)
2005
46
Pain relief by stellate ganglion block in a case with trigeminal neuralgia caused by a cerebellopontine angle tumor. (15384297)
2002
47
Symptomatic trigeminal-autonomic cephalalgia evolving to trigeminal neuralgia: report of a case associated with dual pathology. (11903287)
2001
48
Electrical stimulation of the trigeminal tract in chronic, intractable facial neuralgia. (11935364)
2001
49
Posterior fossa reexploration for persistent or recurrent trigeminal neuralgia or hemifacial spasm: surgical findings and therapeutic implications. (9802855)
1998
50
Trigeminal neuralgia due to dolichoectasia: angiographic and CT findings in a patient with the EEC syndrome. (7443046)
1980

Genetic Variations for Trigeminal Neuralgia

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Expression for genes affiliated with Trigeminal Neuralgia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

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12EMD Millipore, 51QIAGEN
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Pathways related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SCN10A, SCN3A, SCN9A
2
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9.5BMP2, SCN9A, SCN3A, SCN10A
3
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8.6PTN, CRP, BMP2, SCN9A, SCN3A, SCN10A

Compounds for genes affiliated with Trigeminal Neuralgia

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28IUPHAR, 11DrugBank, 44Novoseek, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1saxitoxin2810.2SCN9A, SCN3A
2Lacosamide1110.1SCN9A, SCN3A, SCN10A
3dmsa4410.1CALCA, CRP
4batrachotoxin2810.1SCN10A, SCN3A, SCN9A
5qx 314 chloride5910.0SCN10A, SCN3A, SCN9A
6tetrodotoxin citrate5910.0SCN10A, SCN3A, SCN9A
7phrixotoxin 35910.0SCN10A, SCN3A, SCN9A
8teriparatide44 1111.0ESR1, CALCA
9veratridine44 59 2812.0SCN9A, SCN3A, SCN10A
10ibandronate44 1111.0ESR1, CALCA
11alendronate44 49 1111.9CALCA, BMP2, ESR1
12raloxifene44 28 49 1112.9ESR1, BMP2, CALCA
13tibolone449.8ESR1, CRP, CALCA
14pamidronate44 49 1111.8CRP, CALCA
15tetrodotoxin44 59 2811.7CALCA, SCN10A, SCN3A, SCN9A
16risedronate44 59 49 28 1113.6CALCA, ESR1
17testosterone44 59 11 2412.2CALCA, BMP2, CRP, PGRMC1, ESR1
18vegf448.8ESR1, PTN, CRP, BMP2, CALCA

GO Terms for genes affiliated with Trigeminal Neuralgia

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16Gene Ontology
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Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.7SCN9A, SCN3A, SCN10A

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.7BMP2, CALCA
2sodium ion transportGO:0068149.6SCN9A, SCN3A, SCN10A
3inflammatory responseGO:0069549.4CRP, BMP2, SCN9A, CALCA

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052489.4SCN9A, SCN3A, SCN10A
2identical protein bindingGO:0428028.2ESR1, EMILIN1, TNN, CALCA, JMJD6, BNIPL

Products for genes affiliated with Trigeminal Neuralgia

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  • Antibodies
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Sources for Trigeminal Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet