Summaries for Trigeminal Neuralgia

Sources:
30NIH Rare Diseases, 23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards
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MedlinePlus: Can you imagine feeling a shock in your face as you brush your teeth or shave? if you have trigeminal neuralgia (tn), you may know exactly what it's like. you may feel extreme numbness, tingling or burning on a part of your face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. your trigeminal nerve is responsible for sensations on your face. the cause of tn is probably a blood vessel pressing on the trigeminal nerve. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. tn usually affects people over 50, especially women. medicines and sometimes surgery can help with the pain. nih: national institute of neurological disorders and stroke23

MalaCards: Trigeminal Neuralgia, also known as tic douloureux, is related to tympanosclerosis and vasomotor rhinitis. An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are GHRH Signaling and Sodium channels and transporters- inward current. The drugs carbamazepine and tocainide and the compounds tetrodotoxin citrate and qx 314 chloride have been mentioned in the context of this disorder. Affiliated tissues include brain and skin, and related mouse phenotypes are cardiovascular system and nervous system.

NIH Rare Diseases: Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.  30

NINDS: Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.31

Wikipedia: Trigeminal neuralgia (TN, or TGN), also known as prosopalgia, the suicide disease, or Fothergill\'s...44 more...

Aliases & Descriptions for Trigeminal Neuralgia

Sources:
6Disease Ontology, 30NIH Rare Diseases, 31NINDS, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 24MeSH, 19ICD9CM, 33OMIM
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Aliases & Descriptions:

trigeminal neuralgia 6 30 31 8 32 23 43
tic douloureux 30 31
trigeminal neuralgia nos (disorder) 6
trigeminal neuralgia (disorder) 6
trigeminal neuralgia (disorder) 6
trifacial neuralgia 6
trifocal neuralgia 6

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ICD9CM19 350.1
SNOMED-CT40 322769008, 31681005, 155066002 193090007, more

Related Diseases for Trigeminal Neuralgia

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13GeneCards, 14GeneDecks
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Graphical network of the top 20 diseases related to trigeminal neuralgia:



Graphical network of diseases related to trigeminal neuralgia

Clinical Features for Trigeminal Neuralgia

Drugs & Therapeutics for Trigeminal Neuralgia

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for trigeminal neuralgia

Drug clinical trials:

Search ClinicalTrials for trigeminal neuralgia

Search NIH Clinical Center for trigeminal neuralgia

Search CenterWatch for trigeminal neuralgia

Inferred drug relations via UMLS/NDF-RT:

43 28 baclofen, carbamazepine, tizanidine, tizanidine hydrochloride, tocainide, tocainide hydrochloride

Genetic Tests for Trigeminal Neuralgia

Anatomical Context for Trigeminal Neuralgia

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22MalaCards
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MalaCards organs/tissues related to trigeminal neuralgia:

22
Brain, Skin

Phenotypes for genes affiliated with Trigeminal Neuralgia

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25MGI
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MGI Mouse Phenotypes related to trigeminal neuralgia:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cardiovascular system phenotypeMP:00053857.3CRP, ESR1, CALCA, IFT122, JMJD6, SCN10A
2nervous system phenotypeMP:00036316.1PCLO, CRLF1, PTN, ESR1, CALCA, IFT122

Publications for genes affiliated with Trigeminal Neuralgia

Sources:
35PubMed
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Articles related to trigeminal neuralgia:

idTitleAuthorsYearAffiliating Genes
1Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia. (19699781)Siqueira S.R.... Siqueira J.T.2009SCN3A, SCN9A, SCN10A
2Could calcitonin be a useful therapeutic agent for trigeminal neuralgia? (18343043)Qin H.... Yang F.S.2008CALCA
3Case of tsutsugamushi disease (scrub typhus) present ing with fever and pain indistinguishable from trigeminal neuralgia (17633112)Arai M.... Shichi D.2007CRP
4Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia (16430179)Huang C.J.... Yi P.2005ESR1
5Levels of C-reactive protein and complement 4 fraction in hyperthermia secondary to microsurgical vascular decompression for trigeminal neuralgia (8577354)Charlot M.... Alaywan M.1995CRP

Expression for genes affiliated with Trigeminal Neuralgia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Pathways for genes affiliated with Trigeminal Neuralgia

Sources:
36QIAGEN, 10EMD Millipore
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Pathways related to trigeminal neuralgia according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1GHRH Signaling369.5SCN3A, SCN9A, SCN10A
2Sodium channels and transporters- inward current109.2SCN3A, SCN9A, SCN10A
3Activation of cAMP-Dependent PKA368.0BMP2, SCN3A, SCN9A, SCN10A, PTN, CRP
4cAMP Pathway367.9CRP, PTN, SCN10A, SCN9A, SCN3A, BMP2

Compounds for genes affiliated with Trigeminal Neuralgia

Sources:
42Tocris Bioscience, 32Novoseek , 9DrugBank, 18HMDB
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Compounds related to trigeminal neuralgia according to GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tetrodotoxin citrate42 9.9SCN3A, SCN10A
2qx 314 chloride42 9.9SCN3A, SCN10A
3teriparatide32 9 9 11.6ESR1, CALCA
4ibandronate32 9 9 11.5CALCA, ESR1
5alendronate32 9 9 11.5BMP2, CALCA, ESR1
6raloxifene32 9 9 11.5ESR1, CALCA, BMP2
7tetrodotoxin32 9.4SCN9A, SCN10A, CALCA
8risedronate32 42 9 9 12.3ESR1, CALCA
9dmsa32 9.3CALCA, CRP
10pamidronate32 9 9 11.1CALCA, CRP
11tibolone32 8.9CALCA, ESR1, CRP
12testosterone32 9 18 9 10.9BMP2, CALCA, ESR1, CRP, PGRMC1

GO Terms for genes affiliated with Trigeminal Neuralgia

Sources:
12Gene Ontology
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Cellular components related to trigeminal neuralgia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.2SCN3A, SCN9A, SCN10A
2extracellular spaceGO:0056157.9BMP2, CALCA, TNN, PTN, CRLF1, CRP

Biological processes related to trigeminal neuralgia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ossificationGO:0457789.7BMP2, CALCA
2regulation of heart rateGO:0020279.6SCN10A, CALCA
3sodium ion transportGO:0068149.5SCN3A, SCN9A, SCN10A
4inflammatory responseGO:0069548.2CRP, CALCA, SCN9A, BMP2

Molecular functions related to trigeminal neuralgia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052489.2SCN3A, SCN9A, SCN10A
2identical protein bindingGO:0428028.9BNIPL, JMJD6, ESR1, TNN, EMILIN1

Sources for Trigeminal Neuralgia

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS