MCID: TRG002
MIFTS: 67

Trigeminal Neuralgia malady

Rare diseases, Neuronal diseases categories
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Summaries for Trigeminal Neuralgia

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MedlinePlus:33 Trigeminal neuralgia (tn) is a type of chronic pain that affects your face. it causes extreme, sudden burning or shock-like pain. it usually affects one side of the face. any vibration on your face, even from talking, can set it off. the condition may come and go, disappearing for days or even months. but the longer you have it, the less often it goes away. tn usually affects people over 50, especially women. the cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. tumors and multiple sclerosis can also cause tn, but in some cases the cause is unknown. there is no single test to diagnose tn. it can be hard to diagnose, since many other conditions can cause facial pain. treatment options include medicines, surgery, and complementary techniques. nih: national institute of neurological disorders and stroke

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to diarrhea and arthritis, and has symptoms including An important gene associated with Trigeminal Neuralgia is BMP2 (bone morphogenetic protein 2), and among its related pathways are Synaptic transmission ion currents and Interaction between L1 and Ankyrins. The drugs carbamazepine and baclofen and the compounds zoledronic acid and saxitoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are integument and cardiovascular system.

NIH Rare Diseases:42 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. the pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor.  in some cases, the cause is unknown. treatment options include medicines, surgery, and complementary approaches.   last updated: 9/17/2010

NINDS:43 Trigeminal neuralgia (TN), also called , is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain.

Wikipedia:65 Trigeminal neuralgia (TN, or TGN), also known as prosopalgia,Fothergill\'s disease, or formerly suicide... more...

Description from OMIM:46 190400

Aliases & Classifications for Trigeminal Neuralgia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Trigeminal Neuralgia, Aliases & Descriptions:

Name: Trigeminal Neuralgia 8 42 22 43 10 44 48 46 33 62
Tic Douloureux 42 43 48
Trigeminal Neuralgia Nos 8
 
Trifacial Neuralgia 8
Trifocal Neuralgia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:12098
OMIM46 190400
ICD9CM27 350.1
MeSH34 D014277
MESH via Orphanet35 D014277
ICD10 via Orphanet26 G50.0
UMLS via Orphanet63 C0040997
ICD1025 G50.0

Related Diseases for Trigeminal Neuralgia

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Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to trigeminal neuralgia

Symptoms for Trigeminal Neuralgia

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Symptoms by clinical synopsis from OMIM:

190400

Clinical features from OMIM:

190400

HPO human phenotypes related to Trigeminal Neuralgia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 trigeminal neuralgia HP:0100661

Drugs & Therapeutics for Trigeminal Neuralgia

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Drug clinical trials:

Search ClinicalTrials for Trigeminal Neuralgia

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

id Genetic test Affiliating Genes
1 Trigeminal Neuralgia22

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

32
Brain, Testes, Skin, Trigeminal ganglion, Tongue, Bone, Liver

Animal Models for Trigeminal Neuralgia or affiliated genes

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MGI Mouse Phenotypes related to Trigeminal Neuralgia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1JMJD6, CALCA, ESR1, SCN9A, SCN10A
2MP:00053857.7SCN10A, ESR1, BMP2, CALCA, CRP, JMJD6
3MP:00053867.7SCN10A, SCN9A, SCN3A, ESR1, CALCA, CRLF1
4MP:00036317.3MBD1, SCN10A, SCN9A, ESR1, BMP2, CALCA
5MP:00107687.2SCN9A, SCN3A, ESR1, BMP2, CALCA, CRLF1

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
Fully endoscopic microvascular decompression for trigeminal neuralgia: technique review and early outcomes. (25270137)
2014
2
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)
2014
3
Tentorial dural arteriovenous fistula manifesting as contralateral trigeminal neuralgia: resolution after transarterial Onyx embolization. (24297368)
2013
4
Dyna-CT-assisted percutaneous microballoon compression for trigeminal neuralgia. (23904451)
2013
5
Salvage treatment of trigeminal neuralgia by occipital nerve stimulation. (24104562)
2013
6
Facial pain induced by isolated lateral pterygoid pyomyositis misdiagnosed as trigeminal neuralgia. (23400971)
2013
7
Non-antiepileptic drugs for trigeminal neuralgia. (24297506)
2013
8
Comparative Evaluation of Surgical Procedures for Trigeminal Neuralgia. (24431878)
2013
9
A Review of Percutaneous Treatments for Trigeminal Neuralgia. (24064481)
2013
10
Repeated percutaneous balloon compression for recurrent trigeminal neuralgia: a long-term study. (22120364)
2012
11
Misoprostol as a therapeutic option for trigeminal neuralgia in patients with multiple sclerosis. (22925476)
2012
12
Stereotactic radiosurgery for trigeminal neuralgia: outcomes and complications. (21815736)
2012
13
Botulinum toxin for trigeminal neuralgia--do we have the evidence? (22990690)
2012
14
Non-antiepileptic drugs for trigeminal neuralgia. (21249658)
2011
15
Foramen ovale cannulation guided by intra-operative computed tomography with integrated neuronavigation for the treatment of trigeminal neuralgia. (21503836)
2011
16
Efficacy, safety and tolerability of duloxetine in idiopathic trigeminal neuralgia. (22187799)
2011
17
Microvascular decompression for trigeminal neuralgia: visualization of results in a 3D stereoscopic virtual reality environment. (21506062)
2011
18
Extramedullary relapse presenting as trigeminal neuralgia and diplopia after allogeneic hematopoietic stem cell transplantation. (21576839)
2011
19
Use of botulinum toxin A for drug-refractory trigeminal neuralgia: preliminary report. (20674409)
2011
20
Identification of a persistent primitive trigeminal artery following the transposition technique for trigeminal neuralgia: a case report. (22059208)
2011
21
Microvascular decompression for trigeminal neuralgia due to compression by the vertebral artery: report of 3 cases. (21656442)
2011
22
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
23
Surgical treatment of trigeminal neuralgia. Results from the use of glycerol injection, microvascular decompression, and rhizotomia. (20953805)
2010
24
Assessment and treatment of trigeminal neuralgia. (20852542)
2010
25
Trigeminal Neuralgia in an HIV Patient. (20300421)
2010
26
Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases. (21121797)
2010
27
Lipomatosis of the trigeminal nerve causing trigeminal neuralgia: case report and literature review. (21311625)
2010
28
Image registration strategy of T(1)-weighted and FIESTA MRI sequences in trigeminal neuralgia gamma knife radiosurgery. (20530977)
2010
29
Frameless image-guided radiosurgery for initial treatment of typical trigeminal neuralgia. (21492609)
2010
30
A survey on acupuncture treatment of trigeminal neuralgia. (20397469)
2010
31
Treatment of trigeminal neuralgia with percutaneous glycerol injection into Meckel's cavity: experience in 4012 patients. (20717747)
2010
32
The operative findings in re-do microvascular decompression for recurrent trigeminal neuralgia. (20158349)
2010
33
A case of trigeminal neuralgia complicated by ipsilateral temporal arteritis. (20063018)
2010
34
Salvage gamma knife stereotactic radiosurgery for surgically refractory trigeminal neuralgia. (19084354)
2009
35
Trigeminal neuralgia as initial symptom of paramedian tentorial meningioma. (19169626)
2009
36
Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis. (19138330)
2009
37
Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia. (19475723)
2009
38
Altered somatosensory processing in trigeminal neuralgia. (19365802)
2009
39
Peduncular hallucinosis following microvascular decompression for trigeminal neuralgia without direct brainstem injury: case report. (19229466)
2009
40
Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system. (19925024)
2009
41
Trigeminal neuralgia secondary to meningioma of petroclival localization. (19408646)
2009
42
Typical trigeminal neuralgia associated with brainstem white matter lesions on MRI in patients without criteria of multiple sclerosis. (18958387)
2008
43
Long-term pain response and quality of life in patients with typical trigeminal neuralgia treated with gamma knife stereotactic radiosurgery. (19005382)
2008
44
The Treatment Outcome of Elderly Patients with Idiopathic Trigeminal Neuralgia : Micro-Vascular Decompression versus Gamma Knife Radiosurgery. (19096677)
2008
45
Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia]. (16430179)
2005
46
Demonstration of neurovascular compression in trigeminal neuralgia and hemifacial spasm with magnetic resonance imaging: comparison with surgical findings in 60 consecutive cases. (12648904)
2003
47
Symptomatic trigeminal-autonomic cephalalgia evolving to trigeminal neuralgia: report of a case associated with dual pathology. (11903287)
2001
48
Trigeminal neuralgia caused by contralateral cerebellopontine angle meningioma - case report. (11786938)
2001
49
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
50
Long-term outcome after operation for trigeminal neuralgia in patients with posterior fossa tumors. (8622156)
1996

Variations for Trigeminal Neuralgia

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Expression for genes affiliated with Trigeminal Neuralgia

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Expression patterns in normal tissues for genes affiliated with Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for genes affiliated with Trigeminal Neuralgia

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Compounds for genes affiliated with Trigeminal Neuralgia

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Compounds related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1zoledronic acid4410.1BMP2, CALCA
2saxitoxin2810.0SCN3A, SCN9A
3lidocaine44 28 1111.9SCN9A, SCN10A
4cerivastatin50 44 28 1112.9BMP2, CRP
5dmsa449.9CRP, CALCA
6zonisamide44 50 1111.9SCN9A, SCN3A
7pamidronate44 50 1111.9CALCA, CRP
8pmma449.8CRP, CALCA
9deoxypyridinoline449.8CALCA, CRP
10teriparatide44 1110.8ESR1, CALCA
11ibandronate44 1110.8CALCA, ESR1
12risedronate44 50 28 61 1113.7CALCA, ESR1
13batrachotoxin289.7SCN3A, SCN9A, SCN10A
14nitroglycerin44 1110.7CALCA, CRP
15qx 314 chloride619.7SCN10A, SCN9A, SCN3A
16tetrodotoxin citrate619.7SCN10A, SCN9A, SCN3A
17fluvastatin44 50 28 1112.7CRP, BMP2
18phrixotoxin 3619.7SCN10A, SCN9A, SCN3A
19veratridine44 61 2811.7SCN3A, SCN9A, SCN10A
2025-hydroxyvitamin d449.7CALCA, CRP
21alendronate44 50 1111.5CALCA, BMP2, ESR1
22progestins449.5ESR1, PGRMC1
23raloxifene44 50 28 1112.5ESR1, BMP2, CALCA
24methacholine44 50 1111.4CALCA, CRP
25cyclophosphamide44 50 1111.4ESR1, BMP2, CRP
26vitamin d449.4CALCA, BMP2, ESR1
27tibolone449.3ESR1, CALCA, CRP
28tetrodotoxin44 61 2811.3SCN10A, SCN9A, SCN3A, CALCA
29prostaglandin f2alpha449.2CRP, CALCA
30estrogen448.9PGRMC1, ESR1, BMP2, CALCA
31vegf448.9ESR1, BMP2, CALCA, CRP
32testosterone44 61 24 1111.7PGRMC1, ESR1, BMP2, CALCA, CRP

GO Terms for genes affiliated with Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:0015189.0SCN3A, SCN9A, SCN10A
2extracellular spaceGO:0056159.0CRLF1, CRP, CALCA, BMP2

Biological processes related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart rateGO:0020279.7CALCA, SCN10A
2positive regulation of ossificationGO:0457789.5CALCA, BMP2
3sodium ion transportGO:0068149.4SCN3A, SCN9A, SCN10A
4sodium ion transmembrane transportGO:0357259.3SCN3A, SCN9A, SCN10A
5inflammatory responseGO:0069548.7SCN9A, BMP2, CALCA, CRP

Molecular functions related to Trigeminal Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.5ESR1, PGRMC1
2voltage-gated sodium channel activityGO:0052489.3SCN3A, SCN9A, SCN10A
3identical protein bindingGO:0428027.8BNIPL, ESR1, CALCA, JMJD6
4protein bindingGO:0055156.3BNIPL, PGRMC1, ESR1, BMP2, CALCA, CRP

Products for genes affiliated with Trigeminal Neuralgia

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Sources for Trigeminal Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet