MCID: TRP005
MIFTS: 37

Trophoblastic Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Trophoblastic Neoplasm

MalaCards integrated aliases for Trophoblastic Neoplasm:

Name: Trophoblastic Neoplasm 12 14
Trophoblastic Tumor 12 72 51
Trophoblastic Neoplasms 41 69
Trophoblastic Neoplasm Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4085
MeSH 41 D014328
NCIt 46 C3422
UMLS 69 C0041182

Summaries for Trophoblastic Neoplasm

Disease Ontology : 12 A germ cell and embryonal cancer that derives from trophoblastic tissue.

MalaCards based summary : Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to hydatidiform mole, recurrent, 1 and placental site trophoblastic tumor. An important gene associated with Trophoblastic Neoplasm is INHA (Inhibin Alpha Subunit). The drugs Nitroglycerin and Chorionic Gonadotropin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and placenta.

Wikipedia : 72 Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These... more...

Related Diseases for Trophoblastic Neoplasm

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to Trophoblastic Neoplasm

Symptoms & Phenotypes for Trophoblastic Neoplasm

Drugs & Therapeutics for Trophoblastic Neoplasm

Drugs for Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
2 Chorionic Gonadotropin Phase 4
3
Levoleucovorin Approved, Investigational Phase 2, Phase 3, Phase 1 68538-85-2
4
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
5
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
6
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
7
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
8
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
9
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
10
Captopril Approved Phase 3 62571-86-2 44093
11
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Ribavirin Approved Phase 3 36791-04-5 37542
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
16
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
17
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
18
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
19
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
20
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
21
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
22
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
23
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
24
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
25
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
26
Mesna Approved, Investigational Phase 3 3375-50-6 598
27
Promethazine Approved, Investigational Phase 3 60-87-7 4927
28
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
29
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
30
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
31
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
32
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
33
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
34
Mycophenolic acid Approved Phase 3 24280-93-1 446541
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 2, Phase 3, Phase 1 58-05-9 143 6006
37 Antidotes Phase 2, Phase 3, Phase 1
38 Antimetabolites Phase 2, Phase 3, Phase 1
39 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1
40 Antirheumatic Agents Phase 2, Phase 3
41 Bone Density Conservation Agents Phase 2, Phase 3, Phase 1
42 Calcium, Dietary Phase 2, Phase 3, Phase 1
43 Dermatologic Agents Phase 2, Phase 3
44 Folic Acid Antagonists Phase 2, Phase 3
45 Hematinics Phase 2, Phase 3
46 Immunosuppressive Agents Phase 2, Phase 3, Phase 1
47 Liver Extracts Phase 2, Phase 3, Phase 1
48 Micronutrients Phase 2, Phase 3, Phase 1
49 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
50 Protective Agents Phase 2, Phase 3, Phase 1

Interventional clinical trials:

(show top 50) (show all 88)

# Name Status NCT ID Phase Drugs
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
3 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Unknown status NCT02606539 Phase 2, Phase 3 Methotrexate plus folinic acid alone
4 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
5 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3 amifostine trihydrate
6 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
10 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
11 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
12 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
13 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3 Methotrexate;Vitamin B Complex
14 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
15 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
16 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
17 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3 MTX 1;MTX 2
18 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
19 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3 Etoposide;actinomycin D;methotrexate;vincristine;cyclophosphamide;Paclitaxel;Cisplatin;Carboplatin
20 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
21 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
22 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
23 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
24 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
25 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
26 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
27 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
28 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
29 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
30 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
31 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
32 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
33 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
34 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
35 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
36 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
37 Single Patient Treatment Protocol of TRC105 Combined With Standard-dose Bevacizumab for a Single Patient With Metastatic And Refractory Choriocarcinoma Completed NCT02396511 Phase 2
38 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
39 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
40 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
41 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
42 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2 Avelumab administration at 10mg/kg
43 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
44 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2 pemetrexed disodium
45 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 Phase 2 deferasirox
46 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
47 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
48 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
49 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
50 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: trophoblastic neoplasms

Genetic Tests for Trophoblastic Neoplasm

Anatomical Context for Trophoblastic Neoplasm

MalaCards organs/tissues related to Trophoblastic Neoplasm:

38
Bone, Bone Marrow, Placenta, Brain, T Cells, Colon, Spinal Cord

Publications for Trophoblastic Neoplasm

Articles related to Trophoblastic Neoplasm:

(show all 27)
# Title Authors Year
1
A pilot randomized controlled clinical trial of second uterine curettage versus usual care to determine the effect of re-curettage on patients' need for chemotherapy among women with low risk, nonmetastatic gestational trophoblastic neoplasm in Urmia, Iran. ( 29033610 )
2017
2
Unusual Presentation of Hypothyroidism in a Pregnant Woman, Mimicking Gestational Trophoblastic Neoplasm. ( 27034864 )
2016
3
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm. ( 26599757 )
2015
4
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. ( 25228614 )
2014
5
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
6
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. ( 24106538 )
2013
7
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. ( 22055909 )
2012
8
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. ( 19893031 )
2009
9
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. ( 17940785 )
2008
10
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. ( 18714577 )
2008
11
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. ( 16681792 )
2006
12
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. ( 16263566 )
2005
13
Expression of CDKI p27Kip1 in trophoblastic neoplasm. ( 11776123 )
2000
14
MR appearance of placental site gestational trophoblastic neoplasm. ( 8846312 )
1996
15
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. ( 7515000 )
1994
16
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. ( 7520498 )
1994
17
[Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. ( 7712876 )
1994
18
[Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. ( 1337871 )
1992
19
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. ( 1661266 )
1991
20
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. ( 2846661 )
1988
21
Gestational trophoblastic neoplasm of the uterus: MR assessment. ( 3020607 )
1986
22
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. ( 6094315 )
1984
23
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. ( 6093460 )
1984
24
Nephrotic syndrome in association with a trophoblastic neoplasm. ( 6279345 )
1982
25
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. ( 46716 )
1975
26
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. ( 4377042 )
1973
27
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. ( 4332357 )
1972

Variations for Trophoblastic Neoplasm

Expression for Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for Trophoblastic Neoplasm

GO Terms for Trophoblastic Neoplasm

Cellular components related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of the cytoplasmic side of the plasma membrane GO:0031235 8.62 RASA1 RASA2

Biological processes related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.62 CGA CSH1 GAL INHA
2 negative regulation of Ras protein signal transduction GO:0046580 9.26 RASA1 RASA2
3 response to immobilization stress GO:0035902 9.16 GAL NR0B1
4 negative regulation of phosphorylation GO:0042326 8.96 CDKN1C INHA
5 gonad development GO:0008406 8.62 CGA NR0B1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CGA CSH1 GAL INHA

Sources for Trophoblastic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
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53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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