MCID: TRP005
MIFTS: 43

Trophoblastic Neoplasm malady

Cancer diseases category
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Summaries for Trophoblastic Neoplasm

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65Wikipedia, 33MalaCards
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Wikipedia:65 Trophoblastic neoplasms are neoplasms which derive from trophoblastic tissue. more...

MalaCards: Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to epithelioid trophoblastic tumor and gestational trophoblastic neoplasm. An important gene associated with Trophoblastic Neoplasm is PHLDA2 (pleckstrin homology-like domain, family A, member 2), and among its related pathways are Growth hormone receptor signaling and PI-3K cascade. The drugs etoposide and methotrexate and the compounds nh4cl and sulpiride have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and placenta.

Aliases & Classifications for Trophoblastic Neoplasm

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8Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

trophoblastic neoplasm 8
trophoblastic tumor 8 45
trophoblastic neoplasm nos 8
trophoblastic neoplasms 62


External Ids:

Disease Ontology8 DOID:4085
MeSH35 D014328
NCIt40 C3422

Related Diseases for Trophoblastic Neoplasm

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17GeneCards, 18GeneDecks
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Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor31.5CSH2, CSH1
2gestational trophoblastic neoplasm31.1PSG1, NLRP7, PHLDA2, CDKN1C, CGB5
3ectopic pregnancy30.5PSG1, CGB5
4choriocarcinoma30.5CDKN1C, CSH2, CSHL1, CSH1, GH1, GH2
5gestational trophoblastic tumor30.5CGB5
6precocious puberty30.1GH1, NR0B1, CGB5
7adenocarcinoma29.9FASN, PSG1, CDKN1C, CTSC, CGB5
8cervicitis10.3
9germ cell tumors10.3
10partial hydatidiform mole10.3
11leiomyoma10.3
12vaginitis10.2
13teratoma10.2
14mixed germ cell tumor10.2
15metaphyseal dysplasia10.1NR0B1
16silver-russell syndrome10.1CDKN1C
17wilms tumor10.1CDKN1C, NR0B1
18placental insufficiency10.1CSH2, CSH1
19placental site trophoblastic tumor10.1
20placenta accreta10.1
21nephrotic syndrome10.1
22pleurisy10.1
23hydatidiform mole, recurrent10.1
24kallmann syndrome10.1CGB5, NR0B1
25adrenocortical carcinoma10.1NR0B1, CDKN1C
26adrenal adenoma10.1CDKN1C, NR0B1
27large cell carcinoma10.0PSG1, CGB5
28beckwith-wiedemann syndrome10.0PHLDA2, CDKN1C
29leydig cell tumor10.0CGB5, NR0B1
30arteriovenous fistula10.0
31pulmonary tuberculosis10.0
32placental abruption10.0
33infertility10.0
34arteriovenous malformation10.0
35alopecia10.0
36alopecia areata10.0
37breast cancer10.0
38cervical cancer10.0
39fallopian tube cancer10.0
40hepatitis10.0
41hermaphroditism10.0
42lung cancer10.0
43pneumothorax10.0
44proteinuria10.0
45respiratory failure10.0
46thyroiditis10.0
47tuberculosis10.0
48nonseminomatous germ cell tumor10.0
49erythrocytosis10.0
50testicular germ cell tumor10.0

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to trophoblastic neoplasm

Symptoms for Trophoblastic Neoplasm

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Drugs & Therapeutics for Trophoblastic Neoplasm

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Trophoblastic Neoplasm

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Trophoblastic Neoplasm

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Anatomical Context for Trophoblastic Neoplasm

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33MalaCards
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MalaCards organs/tissues related to Trophoblastic Neoplasm:

33
Uterus, Colon, Placenta

Animal Models for Trophoblastic Neoplasm or affiliated genes

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Publications for Trophoblastic Neoplasm

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52PubMed
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Articles related to Trophoblastic Neoplasm:

(show all 22)
idTitleAuthorsYear
1
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
2
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
3
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. (19893031)
2009
4
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
5
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
6
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
7
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
8
Expression of CDKI p27Kip1 in trophoblastic neoplasm. (11776123)
2000
9
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
10
Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. (7712876)
1994
11
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. (7520498)
1994
12
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. (7515000)
1994
13
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
14
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
15
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. (2846661)
1988
16
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
17
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
18
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
19
Nephrotic syndrome in association with a trophoblastic neoplasm. (6279345)
1982
20
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
21
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
22
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Variations for Trophoblastic Neoplasm

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Expression for genes affiliated with Trophoblastic Neoplasm

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for genes affiliated with Trophoblastic Neoplasm

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CSH1, GH1, GH2
2
Show member pathways
9.6CSH1, GH1, GH2
3
Show member pathways
9.6CSH1, GH1, GH2
4
Show member pathways
9.6CSH1, GH1, GH2
5
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.5CSH2, CSH1, GH1
69.2GH2, GH1, CSH1, CSH2
7
Show member pathways
Type III interferon signaling38
9.2GH2, GH1, CSH1, CSH2
8
Show member pathways
9.2GH2, GH1, CSH1, CSH2

Compounds for genes affiliated with Trophoblastic Neoplasm

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45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1nh4cl459.9CTSC, GH1
2sulpiride45 29 1111.8CGB5, GH1
3leuprolide acetate459.7CGB5, GH1
4glycerol45 24 1111.7NR0B1, GH1, FASN
5clomiphene citrate459.7CGB5, GH1
6oestriol459.7PSG1, CGB5
725-hydroxycholesterol45 29 2411.7CGB5, FASN
811beta-hydroxysteroid459.5CGB5, GH1, FASN
9ibmx45 61 2911.5CGB5, GH1, FASN
10dihydrotestosterone45 29 24 1112.4FASN, GH1, CGB5
11gnrh459.4GH1, NR0B1, CGB5
12acth459.3CGB5, CDKN1C, NR0B1, GH1
13tamoxifen45 51 29 1112.2CGB5, GH1, FASN
14cycloheximide459.1FASN, GH1, CDKN1C, CGB5
15ribonucleic acid459.1GH2, GH1, CGB5
16estradiol45 24 1111.0FASN, PSG1, GH1, CGB5
17testosterone45 61 24 1112.0CGB5, NR0B1, GH1, GH2, FASN
18steroid458.9CGB5, NR0B1, GH1, FASN
19zinc45 249.8CGB5, CTSC, NR0B1, GH1, PSG1
20progesterone45 29 61 24 1112.8FASN, PSG1, GH1, NR0B1, CGB5
21dexamethasone45 51 29 1111.6CGB5, NR0B1, GH1, FASN

GO Terms for genes affiliated with Trophoblastic Neoplasm

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16Gene Ontology
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Cellular components related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1CSHL1, CSH1, GH1, GH2, PSG9, PSG1

Biological processes related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1placenta developmentGO:00189010.0CDKN1C, PHLDA2
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.5CSH1, GH1, GH2
3female pregnancyGO:0075658.9CSH1, PSG9, PSG1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.0CSHL1, CSH1, GH1, GH2

Products for genes affiliated with Trophoblastic Neoplasm

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  • Antibodies
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Sources for Trophoblastic Neoplasm

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet