MCID: TRP005
MIFTS: 36

Trophoblastic Neoplasm malady

Categories: Cancer diseases

Aliases & Classifications for Trophoblastic Neoplasm

Aliases & Descriptions for Trophoblastic Neoplasm:

Name: Trophoblastic Neoplasm 12 14
Trophoblastic Neoplasms 42 69
Trophoblastic Tumor 12 52
Trophoblastic Neoplasm Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4085
MeSH 42 D014328
NCIt 47 C3422
UMLS 69 C0041182

Summaries for Trophoblastic Neoplasm

Disease Ontology : 12 A germ cell and embryonal cancer that derives from trophoblastic tissue.

MalaCards based summary : Trophoblastic Neoplasm, also known as trophoblastic neoplasms, is related to gestational trophoblastic neoplasm and gestational trophoblastic tumor. An important gene associated with Trophoblastic Neoplasm is INHA (Inhibin Alpha Subunit), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Nucleotide-binding Oligomerization Domain (NOD) pathway. The drugs Metformin and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include colon, placenta and uterus.

Wikipedia : 71 Trophoblastic neoplasms are neoplasms which derive from trophoblastic... more...

Related Diseases for Trophoblastic Neoplasm

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to Trophoblastic Neoplasm

Symptoms & Phenotypes for Trophoblastic Neoplasm

Drugs & Therapeutics for Trophoblastic Neoplasm

Drugs for Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 192)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
5 Chorionic Gonadotropin Phase 4
6 Hematinics Phase 4,Phase 3,Phase 2
7 Hypoglycemic Agents Phase 4
8 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
9 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
10 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
11 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
12 Folate Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
13 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
14
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
15
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
16
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
17
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
18
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
19
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
20
Palivizumab Approved, Investigational Phase 3 188039-54-5
21
Ribavirin Approved Phase 3 36791-04-5 37542
22
Fluconazole Approved Phase 3 86386-73-4 3365
23
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
24
Captopril Approved Phase 3 62571-86-2 44093
25
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
26
Levoleucovorin Approved Phase 2, Phase 3, Phase 1 68538-85-2
27
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
28
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
29
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
30
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
31
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
32
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
33
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
34
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
35
Diphenhydramine Approved Phase 3 58-73-1, 147-24-0 3100
36
Mesna Approved Phase 3 3375-50-6 598
37
Promethazine Approved Phase 3 60-87-7 4927
38
Bleomycin Approved Phase 3 11056-06-7 5360373
39
Succinylcholine Approved Phase 3 306-40-1 5314
40
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
41
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
42
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
43
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
44
Norgestimate Approved Phase 3 35189-28-7 6540478
45
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
46
Mycophenolic acid Approved Phase 3 24280-93-1 446541
47 Liver Extracts Phase 3,Phase 2,Phase 1
48 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
49 Antibiotics, Antitubercular Phase 3,Phase 2
50 Anti-Infective Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 87)
id Name Status NCT ID Phase
1 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma Unknown status NCT00294177 Phase 4
2 Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women Completed NCT01115140 Phase 4
3 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
4 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3
5 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
8 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
9 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
10 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
12 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
13 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3
14 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Recruiting NCT02606539 Phase 2, Phase 3
15 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3
16 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3
17 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3
18 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3
19 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Active, not recruiting NCT00053352 Phase 3
20 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3
21 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3
22 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
23 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2
24 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
25 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
26 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
27 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
28 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
29 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2
30 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2
31 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
32 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2
33 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2
34 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
35 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2
36 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
37 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2
38 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2
39 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
40 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
41 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2
42 Single Patient Treatment Protocol of TRC105 Combined With Standard-dose Bevacizumab for a Single Patient With Metastatic And Refractory Choriocarcinoma Active, not recruiting NCT02396511 Phase 2
43 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2
44 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
45 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
46 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
47 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1
48 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1
49 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1
50 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: trophoblastic neoplasms

Genetic Tests for Trophoblastic Neoplasm

Anatomical Context for Trophoblastic Neoplasm

MalaCards organs/tissues related to Trophoblastic Neoplasm:

39
Colon, Placenta, Uterus

Publications for Trophoblastic Neoplasm

Articles related to Trophoblastic Neoplasm:

(show all 26)
id Title Authors Year
1
Unusual Presentation of Hypothyroidism in a Pregnant Woman, Mimicking Gestational Trophoblastic Neoplasm. ( 27034864 )
2016
2
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm. ( 26599757 )
2015
3
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
4
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. ( 25228614 )
2014
5
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. ( 24106538 )
2013
6
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. ( 22055909 )
2012
7
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. ( 19893031 )
2009
8
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. ( 18714577 )
2008
9
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. ( 17940785 )
2008
10
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. ( 16681792 )
2006
11
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. ( 16263566 )
2005
12
Expression of CDKI p27Kip1 in trophoblastic neoplasm. ( 11776123 )
2000
13
MR appearance of placental site gestational trophoblastic neoplasm. ( 8846312 )
1996
14
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. ( 7515000 )
1994
15
[Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. ( 7712876 )
1994
16
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. ( 7520498 )
1994
17
[Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. ( 1337871 )
1992
18
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. ( 1661266 )
1991
19
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. ( 2846661 )
1988
20
Gestational trophoblastic neoplasm of the uterus: MR assessment. ( 3020607 )
1986
21
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. ( 6093460 )
1984
22
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. ( 6094315 )
1984
23
Nephrotic syndrome in association with a trophoblastic neoplasm. ( 6279345 )
1982
24
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. ( 46716 )
1975
25
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. ( 4377042 )
1973
26
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. ( 4332357 )
1972

Variations for Trophoblastic Neoplasm

Expression for Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for Trophoblastic Neoplasm

Pathways related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.61 CDKN1C CGA
2 10.24 NLRP2 NLRP7

GO Terms for Trophoblastic Neoplasm

Cellular components related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intrinsic component of the cytoplasmic side of the plasma membrane GO:0031235 8.62 RASA1 RASA2

Biological processes related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.43 CDKN1C INHA TP63
2 negative regulation of Ras protein signal transduction GO:0046580 9.37 RASA1 RASA2
3 response to immobilization stress GO:0035902 9.32 GAL NR0B1
4 negative regulation of phosphorylation GO:0042326 9.16 CDKN1C INHA
5 adrenal gland development GO:0030325 8.96 CDKN1C NR0B1
6 gonad development GO:0008406 8.62 CGA NR0B1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CGA CSH1 GAL INHA

Sources for Trophoblastic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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