MCID: TRP005
MIFTS: 40

Trophoblastic Neoplasm malady

Cancer category

Summaries for Trophoblastic Neoplasm

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Trophoblastic neoplasms are neoplasms which derive from trophoblastic tissue. more...

MalaCards: Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to epithelioid trophoblastic tumor and gestational trophoblastic neoplasm. An important gene associated with Trophoblastic Neoplasm is PHLDA2 (pleckstrin homology-like domain, family A, member 2). The drugs etoposide and etoposide phosphate and the compounds cloprostenol and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include colon, uterus and placenta.

Aliases & Classifications for Trophoblastic Neoplasm

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

trophoblastic neoplasm 8
trophoblastic tumor 8 45
trophoblastic neoplasm nos 8
trophoblastic neoplasms 61


External Ids:

Disease Ontology8 DOID:4085
NCIt40 C3422
MeSH35 D014328

Related Diseases for Trophoblastic Neoplasm

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor31.3CSH1, CSH2, INHA
2gestational trophoblastic neoplasm31.0INHA, CDKN1C, CGB5, CGA, PHLDA2, NLRP7
3ectopic pregnancy30.4CGA, PSG1, CGB5
4gestational trophoblastic tumor30.3CGB5
5teratoma30.2CGA, CGB5, AFP
6placental site trophoblastic tumor30.1INHA, CGB5, CGA
7placental abruption30.0AFP
8precocious puberty30.0NR0B1, CGB5, CGA
9adenocarcinoma30.0TFPI2, CTSC, PSG1, INHA, CGB5, AFP
10placental choriocarcinoma10.5
11partial hydatidiform mole10.3
12squamous cell carcinoma10.2
13germ cell tumors10.2
14mixed germ cell tumor10.2
15placenta accreta10.1
16n syndrome10.1
17hydatidiform mole, recurrent10.1
18pulmonary tuberculosis10.0
19arteriovenous malformation10.0
20infertility10.0
21alopecia10.0
22alopecia areata10.0
23tuberculosis10.0
24nonseminomatous germ cell tumor10.0
25male germ cell tumor10.0
26erythrocytosis10.0
27testicular germ cell tumor10.0
28invasive mole10.0
29sertoli cell tumor10.0INHA
30placental insufficiency10.0CSH1, CSH2
31hemihypertrophy10.0CDKN1C
32endodermal sinus tumor10.0AFP
33beckwith-wiedemann syndrome10.0PHLDA2, CDKN1C
34extragonadal germ cell tumor10.0CGB5, AFP
35wilms tumor10.0NR0B1, CDKN1C, INHA
36hyperandrogenism10.0CGB5, CGA
37adrenocortical carcinoma10.0INHA, NR0B1, CDKN1C
38adrenal adenoma10.0INHA, CDKN1C, NR0B1
39edwards syndrome10.0CGA, AFP
40thyroiditis10.0CGA
41anencephaly10.0AFP, CGA
42male germ cell tumor, somatic10.0CGA, AFP
43hypogonadism10.0CGA, CGB5, NR0B1
44kallmann syndrome10.0CGB5, CGA, NR0B1
45ovarian cyst10.0CGA, CGB5
46gynecomastia10.0CGB5, CGA, INHA
47klinefelter's syndrome10.0INHA, NR0B1, CGA
48oligospermia10.0CGA, CGB5
49leydig cell tumor10.0CGA, NR0B1, CGB5, INHA
50embryonal cancer10.0CGB5, NLRP7, AFP, CGA

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to trophoblastic neoplasm

Clinical Features for Trophoblastic Neoplasm

Drugs & Therapeutics for Trophoblastic Neoplasm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Trophoblastic Neoplasm

Drug clinical trials:

Search ClinicalTrials for Trophoblastic Neoplasm

Search NIH Clinical Center for Trophoblastic Neoplasm

Search CenterWatch for Trophoblastic Neoplasm

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Trophoblastic Neoplasm

Anatomical Context for Trophoblastic Neoplasm

Sources:
33MalaCards
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MalaCards organs/tissues related to Trophoblastic Neoplasm:

33
Colon, Uterus, Placenta

Animal Models for Trophoblastic Neoplasm or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Trophoblastic Neoplasm

Sources:
51PubMed
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Articles related to Trophoblastic Neoplasm:

(show all 25)
idTitleAuthorsYear
1
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
2
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
3
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. (19893031)
2009
4
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
5
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
6
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
7
Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. (16907865)
2006
8
Epithelioid trophoblastic tumor: review of a rare neoplasm of the chorionic-type intermediate trophoblast. (17149967)
2006
9
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
10
Expression of CDKI p27Kip1 in trophoblastic neoplasm. (11776123)
2000
11
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
12
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
13
Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. (7712876)
1994
14
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. (7520498)
1994
15
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. (7515000)
1994
16
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
17
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
18
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. (2846661)
1988
19
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
20
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
21
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
22
Nephrotic syndrome in association with a trophoblastic neoplasm. (6279345)
1982
23
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
24
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
25
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Genetic Variations for Trophoblastic Neoplasm

Expression for genes affiliated with Trophoblastic Neoplasm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for genes affiliated with Trophoblastic Neoplasm

Compounds for genes affiliated with Trophoblastic Neoplasm

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
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Compounds related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cloprostenol29 4511.3INHA, CGA
211-ketotestosterone4510.3CGB5, CGA
3organon4510.3CGA, CGB5
4trilostane45 1111.3CGA, CGB5
5estradiol benzoate4510.3CGB5, CGA
6leuprolide45 60 29 1113.2CGB5, CGA
717-hydroxypregnenolone4510.2CGB5, CGA
8dihydroprogesterone4510.2CGA, CGB5
9cetrorelix45 29 1112.1CGB5, CGA
108-bromo-cyclic amp4510.1CGA, CGB5
11clomiphene citrate4510.1AFP, CGA, CGB5
123beta-hydroxysteroid4510.1CGA, CGB5, INHA
13ifosfamide45 1111.1CGB5, AFP, CGA
14diethylstilbestrol45 29 1112.1AFP, CGB5, CGA
1522r-hydroxycholesterol45 2911.1CGA, CGB5
16vinblastine45 50 1112.0CGB5, AFP, CGA
17androstenedione45 2411.0CGA, INHA, CGB5
18bleomycin45 1111.0CGA, CGB5, AFP
19buserelin45 29 1112.0CGB5, CGA
20mifepristone45 60 29 1113.0CGA, CGB5, AFP
21leuprolide acetate459.9CGB5, CGA
22gnrh459.9INHA, NR0B1, CGB5, CGA
23ctp459.8CGB5, CGA
24acth459.8NR0B1, CDKN1C, INHA, PAM, CGB5
25testosterone45 60 11 2412.8CGB5, CGA, NR0B1, AFP
26oestriol459.7PSG1, CGB5, CGA, AFP
27lutein459.6CGB5, CGA
28paraffin459.5AFP, CGB5, CGA, INHA
29steroid459.5AFP, CGB5, CGA, INHA, NR0B1
30estradiol45 11 2411.5AFP, PSG1, INHA, CGB5, CGA
31progesterone45 60 29 11 2413.3INHA, NR0B1, AFP, CGB5, CGA, PSG1
32zinc45 2410.3PAM, PSG1, CTSC, CGB5, AFP, NR0B1

GO Terms for genes affiliated with Trophoblastic Neoplasm

Sources:
16Gene Ontology
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Cellular components related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5PAM, INHA, CGA, PSG1, PSG9, PSG6

Biological processes related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.1INHA, CDKN1C
2female pregnancyGO:0075658.9PSG1, PSG9, PSG6, CSH1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8INHA, CGA, CSH1

Products for genes affiliated with Trophoblastic Neoplasm

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trophoblastic Neoplasm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet