MCID: TRP005
MIFTS: 44

Trophoblastic Neoplasm malady

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Summaries for Trophoblastic Neoplasm

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Wikipedia:65 Trophoblastic neoplasms are neoplasms which derive from trophoblastic tissue. more...

MalaCards based summary: Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to gestational trophoblastic tumor and gestational trophoblastic neoplasm. An important gene associated with Trophoblastic Neoplasm is PHLDA2 (pleckstrin homology-like domain, family A, member 2), and among its related pathways are Growth hormone receptor signaling and PI-3K cascade. The drugs etoposide and methotrexate and the compounds nh4cl and sulpiride have been mentioned in the context of this disorder. Affiliated tissues include colon, uterus and placenta.

Disease Ontology:8 A germ cell and embryonal cancer that derives from trophoblastic tissue.

Aliases & Classifications for Trophoblastic Neoplasm

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Trophoblastic Neoplasm, Aliases & Descriptions:

Name: Trophoblastic Neoplasm 8
Trophoblastic Tumor 8 44
 
Trophoblastic Neoplasm Nos 8
Trophoblastic Neoplasms 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4085
MeSH34 D014328
NCIt39 C3422

Related Diseases for Trophoblastic Neoplasm

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Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1gestational trophoblastic tumor31.1CGB5
2gestational trophoblastic neoplasm31.1PSG1, NLRP7, PHLDA2, CDKN1C, CGB5
3ectopic pregnancy30.8PSG1, CGB5
4epithelioid trophoblastic tumor30.7CSH2, CSH1
5precocious puberty30.2GH1, NR0B1, CGB5
6adenocarcinoma29.5FASN, PSG1, CDKN1C, CTSC, CGB5
7choriocarcinoma29.3CDKN1C, CSH2, CSHL1, CSH1, GH1, GH2
8metaphyseal dysplasia10.5NR0B1
9silver-russell syndrome10.4CDKN1C
10wilms tumor10.4CDKN1C, NR0B1
11cervicitis10.4
12germ cell tumors10.4
13partial hydatidiform mole10.4
14placental insufficiency10.3CSH2, CSH1
15leiomyoma10.3
16kallmann syndrome10.3CGB5, NR0B1
17adrenocortical carcinoma10.2NR0B1, CDKN1C
18adrenal cortical adenoma10.2CDKN1C, NR0B1
19placental site trophoblastic tumor10.2
20large cell carcinoma10.2PSG1, CGB5
21beckwith-wiedemann syndrome10.2PHLDA2, CDKN1C
22leydig cell tumor10.2CGB5, NR0B1
23breast cancer10.2
24vaginitis10.2
25teratoma10.2
26mixed germ cell tumor10.2
27hyperprolactinemia10.1CGB5, GH1
28polycystic ovary syndrome10.1CGB5, GH1
29hypogonadism10.1CGB5, NR0B1, GH1
30klippel-trenaunay syndrome10.1
31placenta accreta10.1
32nephrotic syndrome10.1
33pleurisy10.1
34alopecia10.1
35arteriovenous fistula10.1
36cervical cancer10.1
37hepatitis10.1
38pulmonary tuberculosis10.1
39placental abruption10.1
40infertility10.1
41arteriovenous malformation10.1
42alopecia areata10.1
43fallopian tube cancer10.1
44hermaphroditism10.1
45lung cancer10.1
46pneumothorax10.1
47proteinuria10.1
48respiratory failure10.1
49thyroiditis10.1
50tuberculosis10.1

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to trophoblastic neoplasm

Symptoms for Trophoblastic Neoplasm

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Drugs & Therapeutics for Trophoblastic Neoplasm

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Drug clinical trials:

Search ClinicalTrials for Trophoblastic Neoplasm

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Trophoblastic Neoplasm

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Anatomical Context for Trophoblastic Neoplasm

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MalaCards organs/tissues related to Trophoblastic Neoplasm:

32
Colon, Uterus, Placenta

Animal Models for Trophoblastic Neoplasm or affiliated genes

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Publications for Trophoblastic Neoplasm

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Articles related to Trophoblastic Neoplasm:

(show all 24)
idTitleAuthorsYear
1
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. (25396428)
2014
2
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. (25228614)
2014
3
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
4
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
5
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. (19893031)
2009
6
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
7
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
8
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
9
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
10
Expression of CDKI p27Kip1 in trophoblastic neoplasm. (11776123)
2000
11
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
12
Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. (7712876)
1994
13
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. (7520498)
1994
14
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. (7515000)
1994
15
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
16
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
17
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. (2846661)
1988
18
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
19
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
20
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
21
Nephrotic syndrome in association with a trophoblastic neoplasm. (6279345)
1982
22
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
23
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
24
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Variations for Trophoblastic Neoplasm

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Expression for genes affiliated with Trophoblastic Neoplasm

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Expression patterns in normal tissues for genes affiliated with Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for genes affiliated with Trophoblastic Neoplasm

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Pathways related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CSH1, GH1, GH2
2
Show member pathways
9.6GH1, GH2, CSH1
3
Show member pathways
9.6CSH1, GH1, GH2
4
Show member pathways
9.6GH1, CSH1, GH2
5
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.5CSH2, GH1, CSH1
6
Show member pathways
9.2CSH2, CSH1, GH1, GH2
79.2GH2, GH1, CSH1, CSH2
8
Show member pathways
Type III interferon signaling37
9.2GH2, GH1, CSH1, CSH2

Compounds for genes affiliated with Trophoblastic Neoplasm

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Compounds related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1nh4cl449.9CTSC, GH1
2sulpiride44 28 1111.8CGB5, GH1
3leuprolide acetate449.7CGB5, GH1
4glycerol44 24 1111.7NR0B1, GH1, FASN
5clomiphene citrate449.7CGB5, GH1
6oestriol449.7PSG1, CGB5
725-hydroxycholesterol44 28 2411.7CGB5, FASN
811beta-hydroxysteroid449.5CGB5, GH1, FASN
9ibmx44 61 2811.5CGB5, GH1, FASN
10dihydrotestosterone44 28 24 1112.4FASN, GH1, CGB5
11gnrh449.4GH1, NR0B1, CGB5
12acth449.3CGB5, CDKN1C, NR0B1, GH1
13tamoxifen44 50 28 1112.2CGB5, GH1, FASN
14cycloheximide449.1FASN, GH1, CDKN1C, CGB5
15ribonucleic acid449.1GH2, GH1, CGB5
16estradiol44 24 1111.0FASN, PSG1, GH1, CGB5
17testosterone44 61 24 1112.0CGB5, NR0B1, GH1, GH2, FASN
18steroid448.9CGB5, NR0B1, GH1, FASN
19zinc44 249.8CGB5, CTSC, NR0B1, GH1, PSG1
20progesterone44 28 61 24 1112.8FASN, PSG1, GH1, NR0B1, CGB5
21dexamethasone44 50 28 1111.6CGB5, NR0B1, GH1, FASN

GO Terms for genes affiliated with Trophoblastic Neoplasm

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Cellular components related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1CSHL1, CSH1, GH1, GH2, PSG9, PSG1

Biological processes related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1placenta developmentGO:00189010.0CDKN1C, PHLDA2
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.5CSH1, GH1, GH2
3female pregnancyGO:0075658.9CSH1, PSG9, PSG1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.0CSHL1, CSH1, GH1, GH2

Products for genes affiliated with Trophoblastic Neoplasm

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  • Antibodies
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Sources for Trophoblastic Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet