MCID: TRP005
MIFTS: 42

Trophoblastic Neoplasm malady

Cancer diseases category

Summaries for Trophoblastic Neoplasm

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Trophoblastic neoplasms are neoplasms which derive from trophoblastic tissue. more...

MalaCards: Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to epithelioid trophoblastic tumor and gestational trophoblastic neoplasm. An important gene associated with Trophoblastic Neoplasm is PHLDA2 (pleckstrin homology-like domain, family A, member 2). The drugs etoposide and etoposide phosphate and the compounds cloprostenol and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and placenta.

Aliases & Classifications for Trophoblastic Neoplasm

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

trophoblastic neoplasm 8
trophoblastic tumor 8 44
trophoblastic neoplasm nos 8
trophoblastic neoplasms 60


External Ids:

Disease Ontology8 DOID:4085
NCIt39 C3422
MeSH34 D014328

Related Diseases for Trophoblastic Neoplasm

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid trophoblastic tumor31.3INHA, CSH1, CSH2
2gestational trophoblastic neoplasm30.9RNF130, CDKN1C, NR0B1, STARD7, PHLDA2, CTSC
3choriocarcinoma30.7STARD7, TFPI2, PSG1, PSG9, CSH1, CSH2
4gestational trophoblastic tumor30.2CGB5
5placental site trophoblastic tumor30.0CGA, CGB5, INHA
6placental abruption30.0AFP
7thyroiditis30.0CGA
8adenocarcinoma29.9PSG1, CTSC, TFPI2, CGB5, AFP, CDKN1C
9placental choriocarcinoma10.5
10cervicitis10.3
11leiomyoma10.2
12choriocarcinoma of the testis10.1
13squamous cell carcinoma10.1
14vaginitis10.1
15placenta accreta10.0
16nephrotic syndrome10.0
17pleurisy10.0
18hydatidiform mole, recurrent10.0
19arteriovenous fistula10.0
20pulmonary tuberculosis10.0
21arteriovenous malformation10.0
22infertility10.0
23alopecia10.0
24alopecia areata10.0
25breast cancer10.0
26cervical cancer10.0
27choriocarcinoma of ovary10.0
28fallopian tube cancer10.0
29hepatitis10.0
30hermaphroditism10.0
31lung adenocarcinoma10.0
32lung cancer10.0
33pneumothorax10.0
34proteinuria10.0
35respiratory failure10.0
36tuberculosis10.0
37sertoli cell tumor10.0INHA
38placental insufficiency10.0CSH1, CSH2
39hemihypertrophy10.0CDKN1C
40endodermal sinus tumor10.0AFP
41beckwith-wiedemann syndrome10.0PHLDA2, CDKN1C
42extragonadal germ cell tumor10.0AFP, CGB5
43wilms tumor10.0INHA, CDKN1C, NR0B1
44hyperandrogenism10.0CGB5, CGA
45adrenocortical carcinoma10.0INHA, CDKN1C, NR0B1
46adrenal adenoma10.0NR0B1, CDKN1C, INHA
47edwards syndrome10.0AFP, CGA
48anencephaly10.0CGA, AFP
49male germ cell tumor, somatic10.0CGA, AFP
50precocious puberty10.0CGA, CGB5, NR0B1

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to trophoblastic neoplasm

Clinical Features for Trophoblastic Neoplasm

About this section

Drugs & Therapeutics for Trophoblastic Neoplasm

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Trophoblastic Neoplasm

Drug clinical trials:

Search ClinicalTrials for Trophoblastic Neoplasm

Search NIH Clinical Center for Trophoblastic Neoplasm

Search CenterWatch for Trophoblastic Neoplasm

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Trophoblastic Neoplasm

About this section

Anatomical Context for Trophoblastic Neoplasm

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Trophoblastic Neoplasm:

32
Uterus, Colon, Placenta

Animal Models for Trophoblastic Neoplasm or affiliated genes

About this section

Publications for Trophoblastic Neoplasm

About this section
Sources:
50PubMed
See all sources

Articles related to Trophoblastic Neoplasm:

(show all 25)
idTitleAuthorsYear
1
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
2
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
3
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. (19893031)
2009
4
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
5
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
6
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
7
Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. (16907865)
2006
8
Epithelioid trophoblastic tumor: review of a rare neoplasm of the chorionic-type intermediate trophoblast. (17149967)
2006
9
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
10
Expression of CDKI p27Kip1 in trophoblastic neoplasm. (11776123)
2000
11
Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (9808132)
1998
12
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
13
Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. (7712876)
1994
14
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. (7520498)
1994
15
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. (7515000)
1994
16
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
17
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
18
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. (2846661)
1988
19
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
20
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
21
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
22
Nephrotic syndrome in association with a trophoblastic neoplasm. (6279345)
1982
23
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
24
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
25
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Genetic Variations for Trophoblastic Neoplasm

About this section

Expression for genes affiliated with Trophoblastic Neoplasm

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for genes affiliated with Trophoblastic Neoplasm

About this section

Compounds for genes affiliated with Trophoblastic Neoplasm

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
See all sources

Compounds related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cloprostenol28 4411.3INHA, CGA
211-ketotestosterone4410.3CGA, CGB5
3organon4410.3CGB5, CGA
4trilostane44 1111.3CGB5, CGA
5estradiol benzoate4410.3CGA, CGB5
6leuprolide44 59 28 1113.2CGB5, CGA
717-hydroxypregnenolone4410.2CGB5, CGA
8dihydroprogesterone4410.2CGA, CGB5
98-bromo-cyclic amp4410.1CGB5, CGA
10cetrorelix44 28 1112.1CGB5, CGA
11clomiphene citrate4410.1AFP, CGB5, CGA
123beta-hydroxysteroid4410.1CGA, CGB5, INHA
13ifosfamide44 1111.1AFP, CGB5, CGA
14diethylstilbestrol44 28 1112.1AFP, CGB5, CGA
1522r-hydroxycholesterol44 2811.1CGB5, CGA
16vinblastine44 49 1112.0CGA, CGB5, AFP
17androstenedione44 2411.0CGA, CGB5, INHA
18bleomycin44 1111.0CGA, CGB5, AFP
19buserelin44 28 1112.0CGA, CGB5
20mifepristone44 59 28 1113.0CGA, CGB5, AFP
21leuprolide acetate449.9CGA, CGB5
22gnrh449.9CGA, CGB5, NR0B1, INHA
23ctp449.8CGB5, CGA
24acth449.8CGB5, NR0B1, CDKN1C, INHA, PAM
25testosterone44 59 11 2412.8NR0B1, AFP, CGB5, CGA
26oestriol449.7AFP, CGB5, CGA, PSG1
27lutein449.6CGA, CGB5
28paraffin449.5INHA, AFP, CGB5, CGA
29steroid449.5CGA, CGB5, AFP, NR0B1, INHA
30estradiol44 11 2411.5PSG1, CGA, CGB5, AFP, INHA
31progesterone44 59 28 11 2413.3PSG1, CGA, CGB5, AFP, NR0B1, INHA
32zinc44 2410.3PSG1, CTSC, CGB5, AFP, NR0B1, PAM

GO Terms for genes affiliated with Trophoblastic Neoplasm

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5PAM, INHA, CGA, PSG1, PSG9, PSG6

Biological processes related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.1INHA, CDKN1C
2female pregnancyGO:0075658.9PSG1, PSG9, PSG6, CSH1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.8INHA, CGA, CSH1

Products for genes affiliated with Trophoblastic Neoplasm

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Trophoblastic Neoplasm

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet