MCID: TRP005
MIFTS: 37

Trophoblastic Neoplasm malady

Cancer diseases category

Aliases & Classifications for Trophoblastic Neoplasm

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Trophoblastic Neoplasm, Aliases & Descriptions:

Name: Trophoblastic Neoplasm 9
Trophoblastic Tumor 9 43
 
Trophoblastic Neoplasm Nos 9
Trophoblastic Neoplasms 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4085
MeSH33 D014328
NCIt38 C3422

Summaries for Trophoblastic Neoplasm

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Wikipedia:63 Trophoblastic neoplasms are neoplasms which derive from trophoblastic tissue. more...

MalaCards based summary: Trophoblastic Neoplasm, also known as trophoblastic tumor, is related to gestational trophoblastic neoplasm and gestational trophoblastic tumor. An important gene associated with Trophoblastic Neoplasm is PHLDA2 (pleckstrin homology-like domain, family A, member 2), and among its related pathways are Growth hormone receptor signaling and PI-3K cascade. The drugs etoposide and methotrexate and the compounds nh4cl and sulpiride have been mentioned in the context of this disorder. Affiliated tissues include colon, uterus and placenta.

Disease Ontology:9 A germ cell and embryonal cancer that derives from trophoblastic tissue.

Related Diseases for Trophoblastic Neoplasm

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Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1gestational trophoblastic neoplasm31.1PHLDA2, CDKN1C, NLRP7, CGB5, PSG1
2gestational trophoblastic tumor31.0CGB5
3ectopic pregnancy30.8CGB5, PSG1
4epithelioid trophoblastic tumor30.7CSH2, CSH1
5precocious puberty30.2NR0B1, GH1, CGB5
6adenocarcinoma29.5CTSC, FASN, CDKN1C, CGB5, PSG1
7choriocarcinoma29.3CSH2, CDKN1C, CGB5, CSHL1, PSG1, PSG9
8metaphyseal dysplasia10.5NR0B1
9silver-russell syndrome10.4CDKN1C
10cervicitis10.4
11partial hydatidiform mole10.4
12wilms tumor10.4NR0B1, CDKN1C
13placental insufficiency10.3CSH2, CSH1
14leiomyoma10.3
15teratoma10.3
16kallmann syndrome10.2CGB5, NR0B1
17beckwith-wiedemann syndrome10.2CDKN1C, PHLDA2
18adrenal cortical adenoma10.2NR0B1, CDKN1C
19large cell carcinoma10.2PSG1, CGB5
20breast cancer10.2
21vaginitis10.2
22mixed germ cell tumor10.2
23leydig cell tumor10.2CGB5, NR0B1
24chromosomal triplication10.2CDKN1C, CGB5, PSG1
25hyperprolactinemia10.1GH1, CGB5
26polycystic ovary syndrome10.1CGB5, GH1
27adrenocortical carcinoma10.1CDKN1C, NR0B1
28hypogonadism10.1CGB5, GH1, NR0B1
29placental site trophoblastic tumor10.1
30placenta accreta10.1
31nephrotic syndrome10.1
32pleurisy10.1
33testicular germ cell tumor10.1
34lung cancer10.1
35alopecia10.1
36arteriovenous fistula10.1
37hepatitis10.1
38pulmonary tuberculosis10.1
39placental abruption10.1
40infertility10.1
41arteriovenous malformation10.1
42alopecia areata10.1
43fallopian tube cancer10.1
44hermaphroditism10.1
45pneumothorax10.1
46respiratory failure10.1
47thyroiditis10.1
48tuberculosis10.1
49lupus nephritis10.1
50nonseminomatous germ cell tumor10.1

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to trophoblastic neoplasm

Symptoms for Trophoblastic Neoplasm

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Drugs & Therapeutics for Trophoblastic Neoplasm

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Drug clinical trials:

Search ClinicalTrials for Trophoblastic Neoplasm

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Trophoblastic Neoplasm

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Anatomical Context for Trophoblastic Neoplasm

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MalaCards organs/tissues related to Trophoblastic Neoplasm:

31
Colon, Uterus, Placenta

Animal Models for Trophoblastic Neoplasm or affiliated genes

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Publications for Trophoblastic Neoplasm

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Articles related to Trophoblastic Neoplasm:

(show all 24)
idTitleAuthorsYear
1
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. (25396428)
2014
2
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. (25228614)
2014
3
Uterine rupture due to invasive metastatic gestational trophoblastic neoplasm. (24106538)
2013
4
Human chorionic gonadotrophin regression rate as a predictive factor of postmolar gestational trophoblastic neoplasm in high-risk hydatidiform mole: a case-control study. (22055909)
2012
5
Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. (19893031)
2009
6
Two rare cases of methotrexate-induced pneumonitis and pleurisy in patients with gestational trophoblastic neoplasms. (18714577)
2008
7
Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures. (17940785)
2008
8
Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms. (16681792)
2006
9
Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon. (16263566)
2005
10
Expression of CDKI p27Kip1 in trophoblastic neoplasm. (11776123)
2000
11
MR appearance of placental site gestational trophoblastic neoplasm. (8846312)
1996
12
Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms]. (7712876)
1994
13
Metastatic trophoblastic neoplasm: Report of a case with a delay in diagnosis resulting from an unusual presentation. (7520498)
1994
14
Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. (7515000)
1994
15
Immunocytochemical localization of human chorionic gonadotropin and placental lactogen in gestational trophoblastic neoplasms]. (1337871)
1992
16
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. (1661266)
1991
17
Metastatic adnexal trophoblastic neoplasm: contribution of MR imaging. (2846661)
1988
18
Gestational trophoblastic neoplasm of the uterus: MR assessment. (3020607)
1986
19
Metastatic gestational trophoblastic neoplasm. A study of two cases in unusual clinical settings and review of the literature. (6094315)
1984
20
Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. (6093460)
1984
21
Nephrotic syndrome in association with a trophoblastic neoplasm. (6279345)
1982
22
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. (46716)
1975
23
Radioimmunoassay of the beta-subunit of human chorionic gonadotropin, monitor of chemotherapy in gestational trophoblastic neoplasm. (4377042)
1973
24
Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. (4332357)
1972

Variations for Trophoblastic Neoplasm

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Expression for genes affiliated with Trophoblastic Neoplasm

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Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for genes affiliated with Trophoblastic Neoplasm

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Pathways related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CSH1, GH1, GH2
2
Show member pathways
9.6CSH1, GH1, GH2
3
Show member pathways
9.6CSH1, GH1, GH2
4
Show member pathways
9.6CSH1, GH1, GH2
5
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.5CSH2, CSH1, GH1
69.2GH2, GH1, CSH1, CSH2
7
Show member pathways
Type III interferon signaling36
9.2GH2, GH1, CSH1, CSH2
8
Show member pathways
9.2GH2, GH1, CSH1, CSH2

Compounds for genes affiliated with Trophoblastic Neoplasm

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Compounds related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1nh4cl439.9CTSC, GH1
2sulpiride43 28 1211.8CGB5, GH1
3leuprolide acetate439.7CGB5, GH1
4glycerol43 24 1211.7NR0B1, GH1, FASN
5clomiphene citrate439.7CGB5, GH1
6oestriol439.7PSG1, CGB5
725-hydroxycholesterol43 28 2411.7CGB5, FASN
811beta-hydroxysteroid439.5CGB5, GH1, FASN
9ibmx43 59 2811.5CGB5, GH1, FASN
10dihydrotestosterone43 28 24 1212.4FASN, GH1, CGB5
11gnrh439.4GH1, NR0B1, CGB5
12acth439.3CGB5, CDKN1C, NR0B1, GH1
13tamoxifen43 49 28 1212.2CGB5, GH1, FASN
14cycloheximide439.1FASN, GH1, CDKN1C, CGB5
15ribonucleic acid439.1GH2, GH1, CGB5
16estradiol43 24 1211.0FASN, PSG1, GH1, CGB5
17testosterone43 59 24 1212.0CGB5, NR0B1, GH1, GH2, FASN
18steroid438.9CGB5, NR0B1, GH1, FASN
19zinc43 249.8CGB5, CTSC, NR0B1, GH1, PSG1
20progesterone43 28 59 24 1212.8FASN, PSG1, GH1, NR0B1, CGB5
21dexamethasone43 49 28 1211.6CGB5, NR0B1, GH1, FASN

GO Terms for genes affiliated with Trophoblastic Neoplasm

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Cellular components related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1CSHL1, CSH1, GH1, GH2, PSG9, PSG1

Biological processes related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1placenta developmentGO:000189010.0CDKN1C, PHLDA2
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.5CSH1, GH1, GH2
3female pregnancyGO:00075658.9CSH1, PSG9, PSG1

Molecular functions related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.0CSHL1, CSH1, GH1, GH2

Products for genes affiliated with Trophoblastic Neoplasm

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Sources for Trophoblastic Neoplasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet