MCID: TRP008
MIFTS: 36

Tropical Calcific Pancreatitis malady

Genetic diseases (common), Endocrine diseases categories
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Summaries for Tropical Calcific Pancreatitis

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MalaCards based summary: Tropical Calcific Pancreatitis is related to alcoholic pancreatitis and pancreatitis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Matrix Metalloproteinases and Protein digestion and absorption. The compounds fluoride and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone and b cells, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Description from OMIM:46 608189

Aliases & Classifications for Tropical Calcific Pancreatitis

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Tropical Calcific Pancreatitis, Aliases & Descriptions:

Name: Tropical Calcific Pancreatitis 46 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


Related Diseases for Tropical Calcific Pancreatitis

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Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Symptoms for Tropical Calcific Pancreatitis

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Clinical features from OMIM:

608189

Drugs & Therapeutics for Tropical Calcific Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Tropical Calcific Pancreatitis

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

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Anatomical Context for Tropical Calcific Pancreatitis

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MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

32
Pancreas, Bone, B cells

Animal Models for Tropical Calcific Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3SPINK1, CFTR, TCF7L2, CTSB
2MP:00053787.7CTSB, ACE, TCF7L2, CFTR, SPINK1
3MP:00053797.2CTSB, ACE, REG1A, TCF7L2, CFTR, SPINK1
4MP:00053767.1SPINK1, CFTR, TCF7L2, REG1A, ACE, CTSB

Publications for Tropical Calcific Pancreatitis

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Articles related to Tropical Calcific Pancreatitis:

(show all 33)
idTitleAuthorsYear
1
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (22580415)
2013
2
Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. (23564348)
2013
3
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
4
Tropical calcific pancreatitis. (22446928)
2012
5
Tropical calcific pancreatitis in HIV patient. (23188944)
2012
6
Images in clinical medicine. Tropical calcific pancreatitis. (21995390)
2011
7
What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India. (20980338)
2011
8
High prevalence of low bone mineral density in patients with tropical calcific pancreatitis. (21441842)
2011
9
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
10
Outcome of pancreatic ascites in patients with tropical calcific pancreatitis managed using a uniform treatment protocol. (19907961)
2009
11
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis. (19433599)
2009
12
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)
2009
13
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. (19140225)
2009
14
Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (19077465)
2009
15
Tropical calcific pancreatitis. (18590261)
2008
16
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)
2008
17
Genetic aspects of tropical calcific pancreatitis. (18604651)
2008
18
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)
2007
19
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)
2006
20
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (17163998)
2006
21
Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis. (15831926)
2005
22
Tropical calcific pancreatitis presenting as kwashiorkor. (15912980)
2004
23
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)
2002
24
Prospective study of pancreatic b-cell and exocrine function following duct decompression in tropical calcific pancreatitis. (11865345)
2002
25
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)
2002
26
Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. (11151920)
2000
27
Tropical calcific pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. (9195412)
1997
28
Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India. (9109851)
1997
29
Celiac disease and tropical calcific pancreatitis. (8213729)
1993
30
Diabetes secondary to tropical calcific pancreatitis. (1445168)
1992
31
Clinical and biochemical studies in the prediabetic phase of tropical calcific pancreatitis. (1557337)
1992
32
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis. (2205529)
1990
33
Tropical calcific pancreatitis. (7266409)
1980

Variations for Tropical Calcific Pancreatitis

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UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

64
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Tropical Calcific Pancreatitis:

6
id Gene Name Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenicrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Tropical Calcific Pancreatitis

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Expression patterns in normal tissues for genes affiliated with Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

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Pathways related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PRSS1, PRSS2
29.7PRSS2, PRSS1
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4CTSB, CFTR
4
Show member pathways
9.2CTSB, PRSS2, PRSS1
59.2CTSB, ACE
6
Show member pathways
9.1ACE, TCF7L2
79.1PRSS2, PRSS1, CFTR

Compounds for genes affiliated with Tropical Calcific Pancreatitis

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Compounds related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fluoride449.6SPINK1, CFTR
2aprotinin44 1110.5PRSS1, CTSB
3biotin44 24 1111.4CTSB, CFTR
4bumetanide44 61 28 50 1113.3ACE, CFTR
5kininogen449.3CTSB, ACE
6felodipine44 28 1111.3CFTR, ACE
7sildenafil28 44 50 24 1113.2ACE, CFTR
8chloroquine44 2 50 28 1113.1CTSB, CFTR
9creatinine448.9CTSB, ACE, SPINK1
10cysteine448.8CFTR, PRSS1, PRSS2, CTSB
11glucose448.3CTSB, ACE, REG1A, TCF7L2
12trypsinogen447.7CTSB, SPINK1, CFTR, PRSS1, PRSS2, REG1A
13serine447.7SPINK1, CFTR, PRSS1, PRSS2, REG1A, CTRC
14calcium44 50 24 1110.5SPINK1, PRSS1, PRSS2, REG1A, ACE, CTRC

GO Terms for genes affiliated with Tropical Calcific Pancreatitis

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Cellular components related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6CTSB, ACE, REG1A, PRSS2, PRSS1, SPINK1

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.6CTSB, PRSS2
2digestionGO:0075869.4PRSS2, PRSS1
3extracellular matrix disassemblyGO:0226179.3CTSB, PRSS2, PRSS1
4proteolysisGO:0065089.3CTSB, CTRC, PRSS2
5extracellular matrix organizationGO:0301989.1PRSS1, PRSS2, CTSB

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.7CTSB, CTRC
2serine-type endopeptidase activityGO:0042529.0CTRC, PRSS2, PRSS1

Products for genes affiliated with Tropical Calcific Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Tropical Calcific Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet