MCID: TRP008
MIFTS: 30

Tropical Calcific Pancreatitis malady

Endocrine category

Summaries for Tropical Calcific Pancreatitis

Sources:
47OMIM, 33MalaCards
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MalaCards: Tropical Calcific Pancreatitis is related to alcoholic pancreatitis and cystic fibrosis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Immune response Bacterial infections in normal airways and Degradation of the extracellular matrix. The compounds 2-Phenylethylamine and 3-Phenylpropylamine have been mentioned in the context of this disorder. Affiliated tissues include pancreas and b cells, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Description from OMIM:47 608189

Aliases & Classifications for Tropical Calcific Pancreatitis

Sources:
47OMIM, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

tropical calcific pancreatitis 47 61


Related Diseases for Tropical Calcific Pancreatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Tropical Calcific Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1alcoholic pancreatitis30.2CFTR, SPINK1
2cystic fibrosis30.2PRSS1, SPINK1, CFTR
3adenocarcinoma30.2SPINK1, REG1A, PRSS1, CTSB
4pancreatitis, chronic30.2PRSS1, SPINK1, CFTR, REG1A
5kwashiorkor10.2
6celiac disease10.2
7fibrocalculous pancreatic diabetes10.2
8pancreatitis, idiopathic10.2
9arthritis10.0CTSB
10cervical cancer10.0SPINK1
11hypokalemia10.0ACE
12sarcoidosis10.0ACE
13familial adenomatous polyposis10.0TCF7L2
14hereditary pancreatitis10.0PRSS1, SPINK1
15pancreatitis10.0PRSS1, SPINK1
16nephritis10.0ACE
17liver cirrhosis10.0REG1A
18steatorrhea10.0CFTR
19polycystic kidney disease10.0CFTR
20angioedema10.0ACE
21gingival overgrowth10.0CTSB
22sinusitis10.0CFTR
23alzheimer's disease10.0REG1A, CTSB
24recurrent acute pancreatitis10.0SPINK1, CFTR
25prostate cancer10.0SPINK1, TCF7L2, CTSB
26stomach cancer10.0CTSB, TCF7L2, SPINK1
27polycystic kidney disease, autosomal dominant10.0ACE, CFTR
28chronic kidney failure10.0CTSB, REG1A, ACE
29cork-handlers' disease10.0ACE, CFTR
30rheumatoid arthritis10.0CFTR, PRSS2, CTSB
31pancreas disease10.0REG1A, SPINK1, CFTR
32colorectal cancer10.0TCF7L2, REG1A, CTSB
33hepatocellular carcinoma10.0REG1A, SPINK1, TCF7L2
34type 2 diabetes mellitus10.0CTSB, ACE, SPINK1, TCF7L2
35hypertrophy of breast10.0ACE, CFTR, CTSB
36adenoma10.0SPINK1, CTSB, REG1A, TCF7L2
37diabetes mellitus10.0TCF7L2, REG1A, ACE, SPINK1
38breast cancer10.0CFTR, TCF7L2, CTSB
39pneumonia10.0CTSB, CFTR
40pancreatic cancer10.0CFTR, SPINK1, REG1A, PRSS1
41primary hyperoxaluria10.0ACE, REG1A, CFTR
42lung cancer10.0TCF7L2, CFTR, CTSB, SPINK1
43acute pancreatitis10.0CFTR, CTSB, SPINK1, PRSS2, REG1A
44colon cancer10.0CTSB, REG1A, CFTR, TCF7L2, SPINK1

Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Clinical Features for Tropical Calcific Pancreatitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608189

Drugs & Therapeutics for Tropical Calcific Pancreatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tropical Calcific Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Tropical Calcific Pancreatitis

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Search CenterWatch for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

Anatomical Context for Tropical Calcific Pancreatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

33
Pancreas, B cells

Animal Models for Tropical Calcific Pancreatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2REG1A, CFTR, TCF7L2, ACE, SPINK1, CTSB
2MP:00053796.9SPINK1, ACE, TCF7L2, CFTR, REG1A, CTSB

Publications for Tropical Calcific Pancreatitis

Sources:
51PubMed
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Articles related to Tropical Calcific Pancreatitis:

(show all 33)
idTitleAuthorsYear
1
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (22580415)
2013
2
Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. (23564348)
2013
3
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
4
Tropical calcific pancreatitis. (22446928)
2012
5
Tropical calcific pancreatitis in HIV patient. (23188944)
2012
6
Images in clinical medicine. Tropical calcific pancreatitis. (21995390)
2011
7
What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India. (20980338)
2011
8
High prevalence of low bone mineral density in patients with tropical calcific pancreatitis. (21441842)
2011
9
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
10
Outcome of pancreatic ascites in patients with tropical calcific pancreatitis managed using a uniform treatment protocol. (19907961)
2009
11
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis. (19433599)
2009
12
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)
2009
13
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. (19140225)
2009
14
Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (19077465)
2009
15
Tropical calcific pancreatitis. (18590261)
2008
16
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)
2008
17
Genetic aspects of tropical calcific pancreatitis. (18604651)
2008
18
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)
2007
19
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)
2006
20
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (17163998)
2006
21
Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis. (15831926)
2005
22
Tropical calcific pancreatitis presenting as kwashiorkor. (15912980)
2004
23
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)
2002
24
Prospective study of pancreatic b-cell and exocrine function following duct decompression in tropical calcific pancreatitis. (11865345)
2002
25
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)
2002
26
Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. (11151920)
2000
27
Tropical calcific pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. (9195412)
1997
28
Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India. (9109851)
1997
29
Celiac disease and tropical calcific pancreatitis. (8213729)
1993
30
Diabetes secondary to tropical calcific pancreatitis. (1445168)
1992
31
Clinical and biochemical studies in the prediabetic phase of tropical calcific pancreatitis. (1557337)
1992
32
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis. (2205529)
1990
33
Tropical calcific pancreatitis. (7266409)
1980

Genetic Variations for Tropical Calcific Pancreatitis

Expression for genes affiliated with Tropical Calcific Pancreatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

Sources:
54Reactome, 53R&D Systems, 30KEGG
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Pathways related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
9.4CFTR, CTSB
2
Hide members
9.3PRSS1, PRSS2, CTSB
3
Hide members
9.3PRSS1, PRSS2, CTSB
49.2CTSB, ACE
59.1CFTR, PRSS1, PRSS2

Compounds for genes affiliated with Tropical Calcific Pancreatitis

Sources:
11DrugBank, 45Novoseek, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
12-Phenylethylamine1110.0PRSS2, PRSS1
23-Phenylpropylamine1110.0PRSS2, PRSS1
3Monoisopropylphosphorylserine1110.0PRSS1, PRSS2
4Phosphorylisopropane1110.0PRSS1, PRSS2
5benzylamine45 1110.9PRSS1, PRSS2
6benzamidine45 1110.9PRSS1, PRSS2
7fluoride459.5SPINK1, CFTR
8Phosphonoserine119.5REG1A, CFTR
9serine459.2SPINK1, PRSS1, CTSB, CTRC
10kininogen459.2ACE, CTSB
11felodipine45 29 1111.1ACE, CFTR
12sildenafil45 50 29 11 2413.1CFTR, ACE
13glucose458.7TCF7L2, REG1A, CTSB
14cysteine458.5CTSB, PRSS2, PRSS1, CFTR
15trypsinogen457.7SPINK1, CTRC, CTSB, PRSS2, PRSS1, REG1A
16calcium45 50 11 2410.4CTRC, CTSB, PRSS2, PRSS1, REG1A, ACE

GO Terms for genes affiliated with Tropical Calcific Pancreatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4ACE, PRSS1, PRSS2, CTSB
2extracellular regionGO:0055767.3SPINK1, CTSB, PRSS2, PRSS1, REG1A, ACE

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.7PRSS1, PRSS2
2extracellular matrix disassemblyGO:0226179.2CTSB, PRSS2, PRSS1
3extracellular matrix organizationGO:0301989.0PRSS1, PRSS2, CTSB
4proteolysisGO:0065088.1ACE, PRSS1, PRSS2, CTSB, CTRC

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.6CTSB, CTRC
2serine-type endopeptidase activityGO:0042529.0PRSS1, PRSS2, CTRC

Products for genes affiliated with Tropical Calcific Pancreatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tropical Calcific Pancreatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet