MCID: TRP008
MIFTS: 40

Tropical Calcific Pancreatitis malady

Genetic diseases (common), Endocrine diseases categories

Aliases & Classifications for Tropical Calcific Pancreatitis

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Tropical Calcific Pancreatitis, Aliases & Descriptions:

Name: Tropical Calcific Pancreatitis 45 10 22 60
 
Fibrocalculous Pancreatic Diabetes 45 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


External Ids:

OMIM45 608189

Summaries for Tropical Calcific Pancreatitis

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MalaCards based summary: Tropical Calcific Pancreatitis, also known as fibrocalculous pancreatic diabetes, is related to alcoholic pancreatitis and pancreatitis, and has symptoms including autosomal dominant inheritance, autosomal recessive inheritance and abdominal pain. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Matrix Metalloproteinases and Protein digestion and absorption. The compounds fluoride and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone and b cells, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Description from OMIM:45 608189

Related Diseases for Tropical Calcific Pancreatitis

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Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Symptoms for Tropical Calcific Pancreatitis

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Symptoms by clinical synopsis from OMIM:

608189

Clinical features from OMIM:

608189

HPO human phenotypes related to Tropical Calcific Pancreatitis:

(show all 7)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 abdominal pain HP:0002027
4 neoplasm of the pancreas HP:0002894
5 pancreatic calcification HP:0005213
6 chronic pancreatitis HP:0006280
7 insulin-dependent but ketosis-resistant diabetes HP:0008205

Drugs & Therapeutics for Tropical Calcific Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Tropical Calcific Pancreatitis

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

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Genetic tests related to Tropical Calcific Pancreatitis:

id Genetic test Affiliating Genes
1 Tropical Calcific Pancreatitis22

Anatomical Context for Tropical Calcific Pancreatitis

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MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

31
Pancreas, Bone, B cells

Animal Models for Tropical Calcific Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3SPINK1, CFTR, TCF7L2, CTSB
2MP:00053787.7CTSB, ACE, TCF7L2, CFTR, SPINK1
3MP:00053797.2CTSB, ACE, REG1A, TCF7L2, CFTR, SPINK1
4MP:00053767.1SPINK1, CFTR, TCF7L2, REG1A, ACE, CTSB

Publications for Tropical Calcific Pancreatitis

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Articles related to Tropical Calcific Pancreatitis:

(show all 34)
idTitleAuthorsYear
1
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis. (25516642)
2014
2
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (22580415)
2013
3
Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. (23564348)
2013
4
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
5
Tropical calcific pancreatitis. (22446928)
2012
6
Tropical calcific pancreatitis in HIV patient. (23188944)
2012
7
Images in clinical medicine. Tropical calcific pancreatitis. (21995390)
2011
8
What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India. (20980338)
2011
9
High prevalence of low bone mineral density in patients with tropical calcific pancreatitis. (21441842)
2011
10
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
11
Outcome of pancreatic ascites in patients with tropical calcific pancreatitis managed using a uniform treatment protocol. (19907961)
2009
12
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis. (19433599)
2009
13
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)
2009
14
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. (19140225)
2009
15
Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (19077465)
2009
16
Tropical calcific pancreatitis. (18590261)
2008
17
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)
2008
18
Genetic aspects of tropical calcific pancreatitis. (18604651)
2008
19
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)
2007
20
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)
2006
21
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (17163998)
2006
22
Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis. (15831926)
2005
23
Tropical calcific pancreatitis presenting as kwashiorkor. (15912980)
2004
24
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)
2002
25
Prospective study of pancreatic b-cell and exocrine function following duct decompression in tropical calcific pancreatitis. (11865345)
2002
26
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)
2002
27
Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. (11151920)
2000
28
Tropical calcific pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. (9195412)
1997
29
Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India. (9109851)
1997
30
Celiac disease and tropical calcific pancreatitis. (8213729)
1993
31
Diabetes secondary to tropical calcific pancreatitis. (1445168)
1992
32
Clinical and biochemical studies in the prediabetic phase of tropical calcific pancreatitis. (1557337)
1992
33
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis. (2205529)
1990
34
Tropical calcific pancreatitis. (7266409)
1980

Variations for Tropical Calcific Pancreatitis

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UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

62
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Tropical Calcific Pancreatitis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Tropical Calcific Pancreatitis

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Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

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Pathways related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PRSS1, PRSS2
29.7PRSS2, PRSS1
3
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4CTSB, CFTR
4
Show member pathways
9.2CTSB, PRSS2, PRSS1
59.2CTSB, ACE
6
Show member pathways
9.1ACE, TCF7L2
79.1PRSS2, PRSS1, CFTR

Compounds for genes affiliated with Tropical Calcific Pancreatitis

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Compounds related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fluoride439.6SPINK1, CFTR
2aprotinin43 1210.5PRSS1, CTSB
3biotin43 24 1211.4CTSB, CFTR
4bumetanide43 59 28 49 1213.3ACE, CFTR
5kininogen439.3CTSB, ACE
6felodipine43 28 1211.3CFTR, ACE
7sildenafil28 43 49 24 1213.2ACE, CFTR
8chloroquine43 2 49 28 1213.1CTSB, CFTR
9creatinine438.9CTSB, ACE, SPINK1
10cysteine438.8CFTR, PRSS1, PRSS2, CTSB
11glucose438.3CTSB, ACE, REG1A, TCF7L2
12trypsinogen437.7CTSB, SPINK1, CFTR, PRSS1, PRSS2, REG1A
13serine437.7SPINK1, CFTR, PRSS1, PRSS2, REG1A, CTRC
14calcium43 49 24 1210.5SPINK1, PRSS1, PRSS2, REG1A, ACE, CTRC

GO Terms for genes affiliated with Tropical Calcific Pancreatitis

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Cellular components related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.6CTSB, ACE, REG1A, PRSS2, PRSS1, SPINK1

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.6CTSB, PRSS2
2digestionGO:00075869.4PRSS2, PRSS1
3extracellular matrix disassemblyGO:00226179.3CTSB, PRSS2, PRSS1
4proteolysisGO:00065089.3CTSB, CTRC, PRSS2
5extracellular matrix organizationGO:00301989.1PRSS1, PRSS2, CTSB

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:00082339.7CTSB, CTRC
2serine-type endopeptidase activityGO:00042529.0CTRC, PRSS2, PRSS1

Products for genes affiliated with Tropical Calcific Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Tropical Calcific Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet