MCID: TRP008
MIFTS: 36

Tropical Calcific Pancreatitis malady

Genetic diseases (common), Endocrine diseases categories
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Summaries for Tropical Calcific Pancreatitis

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47OMIM, 33MalaCards
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MalaCards: Tropical Calcific Pancreatitis is related to pancreatitis and alcoholic pancreatitis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Matrix Metalloproteinases and Protein digestion and absorption. The compounds fluoride and aprotinin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone and b cells, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Description from OMIM:47 608189

Aliases & Classifications for Tropical Calcific Pancreatitis

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47OMIM, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


Aliases & Descriptions:

tropical calcific pancreatitis 47 62


Related Diseases for Tropical Calcific Pancreatitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Symptoms for Tropical Calcific Pancreatitis

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47OMIM
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Clinical features from OMIM:

608189

Drugs & Therapeutics for Tropical Calcific Pancreatitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Tropical Calcific Pancreatitis

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

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Anatomical Context for Tropical Calcific Pancreatitis

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33MalaCards
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MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

33
Pancreas, Bone, B cells

Animal Models for Tropical Calcific Pancreatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.3SPINK1, CFTR, TCF7L2, CTSB
2MP:00053787.7CTSB, ACE, TCF7L2, CFTR, SPINK1
3MP:00053797.2CTSB, ACE, REG1A, TCF7L2, CFTR, SPINK1
4MP:00053767.1SPINK1, CFTR, TCF7L2, REG1A, ACE, CTSB

Publications for Tropical Calcific Pancreatitis

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52PubMed
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Articles related to Tropical Calcific Pancreatitis:

(show all 30)
idTitleAuthorsYear
1
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (22580415)
2013
2
Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. (23564348)
2013
3
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
4
Tropical calcific pancreatitis. (22446928)
2012
5
Tropical calcific pancreatitis in HIV patient. (23188944)
2012
6
Images in clinical medicine. Tropical calcific pancreatitis. (21995390)
2011
7
What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India. (20980338)
2011
8
High prevalence of low bone mineral density in patients with tropical calcific pancreatitis. (21441842)
2011
9
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
10
Outcome of pancreatic ascites in patients with tropical calcific pancreatitis managed using a uniform treatment protocol. (19907961)
2009
11
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis. (19433599)
2009
12
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)
2009
13
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. (19140225)
2009
14
Tropical calcific pancreatitis. (18590261)
2008
15
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)
2008
16
Genetic aspects of tropical calcific pancreatitis. (18604651)
2008
17
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)
2007
18
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)
2006
19
Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis. (15831926)
2005
20
Tropical calcific pancreatitis presenting as kwashiorkor. (15912980)
2004
21
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)
2002
22
Prospective study of pancreatic b-cell and exocrine function following duct decompression in tropical calcific pancreatitis. (11865345)
2002
23
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)
2002
24
Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. (11151920)
2000
25
Tropical calcific pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. (9195412)
1997
26
Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India. (9109851)
1997
27
Celiac disease and tropical calcific pancreatitis. (8213729)
1993
28
Diabetes secondary to tropical calcific pancreatitis. (1445168)
1992
29
Clinical and biochemical studies in the prediabetic phase of tropical calcific pancreatitis. (1557337)
1992
30
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis. (2205529)
1990

Variations for Tropical Calcific Pancreatitis

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

64
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Tropical Calcific Pancreatitis:

1
id Gene Name Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Tropical Calcific Pancreatitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters, 54R&D Systems
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Pathways related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PRSS1, PRSS2
29.7PRSS2, PRSS1
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4CTSB, CFTR
4
Show member pathways
9.2CTSB, PRSS2, PRSS1
59.2CTSB, ACE
6
Show member pathways
9.1ACE, TCF7L2
79.1PRSS2, PRSS1, CFTR

Compounds for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1fluoride459.6SPINK1, CFTR
2aprotinin45 1110.5PRSS1, CTSB
3biotin45 24 1111.4CTSB, CFTR
4bumetanide45 61 29 51 1113.3ACE, CFTR
5kininogen459.3CTSB, ACE
6felodipine45 29 1111.3CFTR, ACE
7sildenafil29 45 51 24 1113.2ACE, CFTR
8chloroquine45 3 51 29 1113.1CTSB, CFTR
9creatinine458.9CTSB, ACE, SPINK1
10cysteine458.8CFTR, PRSS1, PRSS2, CTSB
11glucose458.3CTSB, ACE, REG1A, TCF7L2
12trypsinogen457.7CTSB, SPINK1, CFTR, PRSS1, PRSS2, REG1A
13serine457.7SPINK1, CFTR, PRSS1, PRSS2, REG1A, CTRC
14calcium45 51 24 1110.5SPINK1, PRSS1, PRSS2, REG1A, ACE, CTRC

GO Terms for genes affiliated with Tropical Calcific Pancreatitis

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16Gene Ontology
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Cellular components related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6CTSB, ACE, REG1A, PRSS2, PRSS1, SPINK1

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:0305749.6CTSB, PRSS2
2digestionGO:0075869.4PRSS2, PRSS1
3extracellular matrix disassemblyGO:0226179.3CTSB, PRSS2, PRSS1
4proteolysisGO:0065089.3CTSB, CTRC, PRSS2
5extracellular matrix organizationGO:0301989.1PRSS1, PRSS2, CTSB

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.7CTSB, CTRC
2serine-type endopeptidase activityGO:0042529.0CTRC, PRSS2, PRSS1

Products for genes affiliated with Tropical Calcific Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tropical Calcific Pancreatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet