Tropical Calcific Pancreatitis malady

MalaCards: Tropical Calcific Pancreatitis is related to pancreatitis and cystic fibrosis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Activation of Matrix Metalloproteinases and Bacterial infections in CF airways. The compounds 2-Phenylethylamine and 3-Phenylpropylamine have been mentioned in the context of this disorder. Related mouse phenotype endocrine/exocrine gland.

OMIM: 608189

tropical calcific pancreatitis 7 33 43

Diseases related to tropical calcific pancreatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 53)

id	Related Disease	Score	Top Affiliating Genes
1	pancreatitis	29.9	PRSS1, PRSS2, TCF7L2, ACE, CTSB, CTRC
2	cystic fibrosis	26.7	PRSS1, PRSS2, TCF7L2, ACE, SPINK1, CFTR
3	fibrosis	26.6	PRSS1, PRSS2, TCF7L2, ACE, SPINK1, CFTR
4	hereditary pancreatitis	13.2	PRSS1, SPINK1
5	ovarian cyst	13.0	PRSS2, SPINK1
6	cerebral atherosclerosis	12.9	ACE, REG1A
7	pemphigus foliaceus	12.8	PRSS2, ACE
8	alcoholic pancreatitis	12.7	SPINK1, CFTR
9	membranous glomerulonephritis	12.7	CTSB, ACE
10	diabetes, type 2	12.7	ACE, TCF7L2
11	steatorrhea	12.6	CFTR, PRSS1
12	familial pancreatic cancer	12.4	PRSS1, SPINK1, CFTR
13	familial adenomatous polyposis	12.4	SPINK1, ACE, TCF7L2
14	intestinal pseudo-obstruction	12.4	CFTR, SPINK1, PRSS1
15	primary hyperparathyroidism	12.3	CFTR, SPINK1, PRSS1
16	polycystic kidney disease, autosomal dominant	12.3	CFTR, ACE
17	chronic kidney failure	12.3	REG1A, CTSB, ACE
18	gastric adenocarcinoma	12.2	PRSS1, CTSB, REG1A
19	hypokalemia	12.1	CFTR, ACE
20	hyperparathyroidism	12.0	PRSS1, SPINK1, CFTR
21	nephritis	12.0	CTSB, ACE, PRSS1
22	pulmonary sarcoidosis	12.0	ACE, CTSB, CFTR
23	pancreatic diseases	12.0	PRSS2, SPINK1, CFTR, REG1A
24	polycystic kidney disease	11.9	ACE, CTSB, CFTR
25	type 2 diabetes mellitus	11.9	TCF7L2, ACE, CTSB, SPINK1
26	sarcoidosis	11.8	ACE, CTSB, CFTR
27	sinusitis	11.8	CFTR, CTSB, ACE
28	polyposis	11.6	CFTR, SPINK1, ACE, TCF7L2
29	hypertrophy of breast	11.5	ACE, CTSB, CFTR
30	lung carcinoma	11.5	TCF7L2, CTSB, SPINK1, CFTR
31	photosensitive trichothiodystrophy	11.4	TCF7L2, ACE, CTSB, CFTR
32	duodenitis	11.4	CFTR, CTSB, PRSS1
33	ulcerative colitis	11.4	TCF7L2, ACE, CFTR, REG1A
34	cervicitis	11.2	PRSS2, ACE, CTSB, SPINK1, CFTR
35	adenoma	11.1	TCF7L2, CTSB, SPINK1, CFTR, REG1A
36	immunodeficiency	11.1	PRSS1, PRSS2, TCF7L2, ACE, CTSB, SPINK1
37	colon carcinoma	11.1	TCF7L2, ACE, CTSB, SPINK1, CFTR
38	gastric cancer	11.0	PRSS2, TCF7L2, ACE, CTSB, SPINK1, REG1A
39	colon cancer	11.0	REG1A, CFTR, SPINK1, CTSB, TCF7L2
40	gonococcal synovitis	11.0	PRSS1, PRSS2, CTSB, SPINK1, CFTR, REG1A
41	cholesterol	10.8	TCF7L2, ACE, CTSB, CFTR, REG1A
42	nephropathy	10.7	PRSS1, PRSS2, TCF7L2, ACE, CTSB, SPINK1
43	colorectal cancer	10.7	PRSS1, PRSS2, TCF7L2, ACE, CTSB, SPINK1
44	esophagitis	10.6	TCF7L2, ACE, CTSB, SPINK1, CFTR, REG1A
45	acute pancreatitis	10.5	PRSS1, PRSS2, ACE, CTSB, SPINK1, CFTR
46	pancreatic cancer	10.5	PRSS1, PRSS2, ACE, CTSB, SPINK1, CFTR
47	alzheimer's disease	10.5	PRSS1, TCF7L2, ACE, CTSB, CFTR, REG1A
48	prostate carcinoma	10.3	PRSS1, PRSS2, TCF7L2, ACE, CTSB, SPINK1
49	diabetes mellitus	10.3	PRSS1, TCF7L2, ACE, CTSB, SPINK1, CFTR
50	adenocarcinoma	10.2	PRSS1, TCF7L2, ACE, CTSB, SPINK1, CFTR

Clinical features from OMIM: 608189

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to tropical calcific pancreatitis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	7.2	REG1A, CFTR, SPINK1, CTSB, ACE, TCF7L2

Articles related to tropical calcific pancreatitis:

id	Title	Authors	Year	Affiliating Genes
1	Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)	Derikx M.H.... Drenth J.P.	2009	CTRC, SPINK1
2	TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)	Mahurkar S.... Chandak G.R.	2008	CTSB, TCF7L2, SPINK1
3	Genetic aspects of tropical calcific pancreatitis. (18604651)	Witt H.... Bhatia E.	2008	PRSS2
4	Divergent Roles of SPINK1 and PRSS2 Variants in Tropical Calcific Pancreatitis. (19077465)	Sundaresan S.... Drenth J.P.	2008	PRSS1, SPINK1, PRSS2
5	Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)	Mahurkar S.... Chandak G.R.	2007	CTSB, REG1A, SPINK1
6	Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)	Mahurkar S.... Chandak G.R.	2006	CTSB, SPINK1
7	Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (17163998)	Bhaskar S.... Chandak G.R.	2006	ACE, SPINK1
8	Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)	Bhatia E.... Witt H.	2002	PRSS1, SPINK1
9	Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)	Chandak G.R.... Singh L.	2002	PRSS1, SPINK1
10	Mutations in the cystic fibrosis transmembrane regula tor gene in patients with tropical calcific pancreatitis. (11151920)	Bhatia E.... Tsui L.C.	2000	CFTR

Genes related to tropical calcific pancreatitis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SPINK1	serine peptidase inhibitor, Kazal type 1	11.1	Publications, Summaries
2	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
3	CTRC	chymotrypsin C (caldecrin)	11.0	Publications
4	PRSS1	protease, serine, 1 (trypsin 1)	11.0	Publications
5	REG1A	regenerating islet-derived 1 alpha	11.0	Publications
6	CTSB	cathepsin B	11.0	Publications
7	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	11.0	Publications
8	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
9	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications

Pathways related to tropical calcific pancreatitis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Activation of Matrix Metalloproteinases38	9.4	PRSS2, PRSS1
2	Bacterial infections in CF airways41	9.1	CFTR, CTSB
3	Pancreatic secretion20	8.8	CFTR, PRSS2, PRSS1

Compounds related to tropical calcific pancreatitis according to GeneDecks:

(show all 11)

id	Compound	Score	Top Affiliating Genes
1	2-Phenylethylamine9 9	10.9	PRSS1, PRSS2
2	3-Phenylpropylamine9 9	10.9	PRSS2, PRSS1
3	Phosphorylisopropane9 9	10.9	PRSS1, PRSS2
4	Monoisopropylphosphorylserine9 9	10.8	PRSS2, PRSS1
5	benzylamine32 9 9	11.7	PRSS1, PRSS2
6	benzamidine32 9 9	11.4	PRSS1, PRSS2
7	fluoride32	9.3	SPINK1, CFTR
8	Phosphonoserine9 9	10.1	REG1A, CFTR
9	calcium32 9 18 9	10.6	SPINK1, PRSS2, PRSS1, ACE, REG1A, CTSB
10	trypsinogen32	7.5	CTSB, PRSS1, PRSS2, CTRC, SPINK1, CFTR
11	serine32	7.4	REG1A, PRSS1, CFTR, SPINK1, CTRC, CTSB

Cellular components related to tropical calcific pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.7	CTSB, ACE, PRSS2, PRSS1

Biological processes related to tropical calcific pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:022617	9.7	PRSS2, PRSS1
2	proteolysis	GO:006508	8.0	CTRC, CTSB, ACE, PRSS2, PRSS1

Molecular functions related to tropical calcific pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:004252	9.3	CTRC, PRSS2, PRSS1