MCID: TRP008
MIFTS: 41

Tropical Calcific Pancreatitis malady

Categories: Genetic diseases (common), Endocrine diseases

Aliases & Classifications for Tropical Calcific Pancreatitis

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Aliases & Descriptions for Tropical Calcific Pancreatitis:

Name: Tropical Calcific Pancreatitis 49 11 67 24 65
Fibrocalculous Pancreatic Diabetes 49 65
 
Tcp 67

Characteristics:

HPO:

61
tropical calcific pancreatitis:
Inheritance: autosomal dominant inheritance, autosomal recessive inheritance


Classifications:



External Ids:

OMIM49 608189
MedGen34 C1842402
UMLS65 C1842402, C0271642

Summaries for Tropical Calcific Pancreatitis

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UniProtKB/Swiss-Prot:67 Tropical calcific pancreatitis: Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

MalaCards based summary: Tropical Calcific Pancreatitis, also known as fibrocalculous pancreatic diabetes, is related to pancreatitis and fibrocalculous pancreatopathy, and has symptoms including abdominal pain, neoplasm of the pancreas and pancreatic calcification. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways are Matrix Metalloproteinases and Protein digestion and absorption. Affiliated tissues include prostate, pancreas and bone, and related mouse phenotype endocrine/exocrine gland.

Description from OMIM:49 608189

Related Diseases for Tropical Calcific Pancreatitis

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Graphical network of diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Symptoms for Tropical Calcific Pancreatitis

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Symptoms by clinical synopsis from OMIM:

608189

Clinical features from OMIM:

608189

HPO human phenotypes related to Tropical Calcific Pancreatitis:

id Description Frequency HPO Source Accession
1 abdominal pain HP:0002027
2 neoplasm of the pancreas HP:0002894
3 pancreatic calcification HP:0005213
4 chronic pancreatitis HP:0006280
5 insulin-dependent but ketosis-resistant diabetes HP:0008205

Drugs & Therapeutics for Tropical Calcific Pancreatitis

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Drugs for Tropical Calcific Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ergocalciferolapproved, nutraceuticalPhase 492350-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
2
Cholecalciferolapproved, nutraceuticalPhase 479967-97-06221, 10883523, 5280795
Synonyms:
()-Vitamin D3
(+)-Vitamin D3
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(3beta,Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
(5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
(5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7e)-(3S)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
1406-16-2
25(OH)D
3-beta,Z,7E-9,10-Secocholestr-5,7,10(19)-trien-3-ol
47763_SUPELCO
57651-82-8
67-97-0
7-Dehydrocholesterol activated
7-Dehydrocholesterol, Activated
7-Dehydrocholesterol, irradiated
7-Dehydrocholestrol, activated
8024-19-9
8050-67-7
89193_FLUKA
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol
9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol
9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(.beta.)-ol
9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
9,10-Secocholesta-5,7,10(19)-trien-3-ol
9,10-Secocholesta-5,7,10-trien-3-ol
AB1002422
AC-11697
AC1L1ECK
AC1L1M23
AC1LU7IZ
AC1NQXLN
AC1NR2UO
AC1NR2UR
AC1NR2UU
AC1NS4AJ
AC1NSHJX
AC1O5EOF
AC1O7GAV
AC1O7GQ3
AC1O8FEU
AC1O8PWJ
AC1OF2GI
AC1OF2GL
AC1OIEW5
AC1OIEWB
ACon1_001997
Activated 7-dehydrocholesterol
Arachitol
BPBio1_000460
BSPBio_000418
BSPBio_002408
Bio-0845
C05443
C1357_SIAL
C27H44O
C9756_SIGMA
C9774_SIAL
CAS-67-97-0
CC
CCRIS 5813
CCRIS 6286
CHEBI:283119
CHEBI:28940
CHEMBL1042
CHEMBL432780
CID10000117
CID10045875
CID10340013
CID10883523
CID10894379
CID11014566
CID11025493
CID11058152
CID11463269
CID1548921
CID2735
CID5280795
CID5283710
CID5283711
CID5283712
CID5353527
CID5363362
CID6221
CID6432644
CID6604201
CID6604662
CID6708595
CID6713938
CID6992015
CID6992016
CID7067439
CID7067440
CID7251172
CID7251174
CID9821465
Calciol
Cholecalciferol
Cholecalciferol (D3)
Cholecalciferol (JP15/USP)
Cholecalciferol D3
Cholecalciferol [USAN:BAN:JAN]
Cholecalciferol, D3
Cholecalciferolum
 
Colecalciferol
Colecalciferol (INN)
Colecalciferolo
Colecalciferolo [DCIT]
Colecalciferolum
Colecalciferolum [INN-Latin]
Colecalcipherol
D00188
D3-Vicotrat
D3-Vigantol
DB00169
Delsterol
Delta-D
Delta-D (TN)
Deparal
Devaron
DivK1c_006276
Duphafral D3 1000
EINECS 200-673-2
EINECS 215-797-2
EPA Pesticide Chemical Code 202901
Ebivit
FeraCol
Granuvit D3
HMS1569E20
HMS2092M12
HSDB 820
I05-0041
Irradiated 7-dehydrocholesterol
KBio1_001220
KBio2_001643
KBio2_004211
KBio2_006779
KBio3_001628
KBioGR_001602
KBioSS_001643
LMST03020001
LMST03020219
LMST03020220
LMST03020221
LS-1570
LS-825
LT00244775
MEGxm0_000458
Micro-dee
MolPort-001-740-051
MolPort-001-785-972
MolPort-003-666-021
MolPort-004-946-964
NCGC00016301-01
NCGC00017328-01
NCGC00091072-01
NCGC00142511-01
NCGC00159331-02
NCGC00159331-04
NCGC00178668-01
NCGC00179565-01
NCGC00179565-02
NEO Dohyfral D3
NSC 375571
NSC-375571
NSC375571
Oleovitamin D3
Prestwick0_000429
Prestwick1_000429
Prestwick2_000429
Prestwick3_000429
Prestwick_63
Provitamine
Provitina
Quintox
Rampage
Ricketon
SMP1_000068
SPBio_001298
SPBio_002357
SR-05000001559
SR-05000001559-3
ST057172
SpecPlus_000180
Spectrum2_001369
Spectrum3_000764
Spectrum4_001201
Spectrum_001163
TNP00266
Trivitan
UNII-1C6V77QF41
UPCMLD-DP152
UPCMLD-DP152:001
VITAMIN D
VITAMIN D3 POWDER
VITAMIN_D3
Vi-De3
Vi-de-3-hydrosol
VidDe-3-hydrosol
Videkhol
Vigantol
Vigorsan
Vitamin D3
Vitamin D3 emulsifiable
Vitinc Dan-Dee-3
ZINC04474460
ZINC04492874
ZINC04492875
ZINC04492876
ZINC04492878
bmse000507
calciol
cholecalciferol
delta-D
vitamin d-3
3vitamin dPhase 41524
4VitaminsPhase 43857
5Trace ElementsPhase 43900
6ErgocalciferolsPhase 4923
7MicronutrientsPhase 43901
8Bone Density Conservation AgentsPhase 42600
9CalciferolNutraceuticalPhase 41074
10Vitamin D2NutraceuticalPhase 4923

Interventional clinical trials:

idNameStatusNCT IDPhase
1Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific PancreatitisCompletedNCT00956839Phase 4

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

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Anatomical Context for Tropical Calcific Pancreatitis

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MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

33
Prostate, Pancreas, Bone, Breast, Liver, Colon, Endothelial

Animal Models for Tropical Calcific Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.8ACE, CTSB, REG1A, SPINK1, TCF7L2

Publications for Tropical Calcific Pancreatitis

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Articles related to Tropical Calcific Pancreatitis:

(show all 35)
idTitleAuthorsYear
1
Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model. (26784911)
2016
2
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis. (25516642)
2014
3
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (22580415)
2013
4
Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. (23564348)
2013
5
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
6
Tropical calcific pancreatitis. (22446928)
2012
7
Tropical calcific pancreatitis in HIV patient. (23188944)
2012
8
Images in clinical medicine. Tropical calcific pancreatitis. (21995390)
2011
9
What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India. (20980338)
2011
10
High prevalence of low bone mineral density in patients with tropical calcific pancreatitis. (21441842)
2011
11
Anomalous pancreaticobiliary ductal union in tropical calcific pancreatitis. (20065547)
2010
12
Outcome of pancreatic ascites in patients with tropical calcific pancreatitis managed using a uniform treatment protocol. (19907961)
2009
13
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis. (19433599)
2009
14
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (19404200)
2009
15
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis. (19140225)
2009
16
Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (19077465)
2009
17
Tropical calcific pancreatitis. (18590261)
2008
18
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (18706099)
2008
19
Genetic aspects of tropical calcific pancreatitis. (18604651)
2008
20
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (17990360)
2007
21
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (16492714)
2006
22
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis. (17163998)
2006
23
Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis. (15831926)
2005
24
Tropical calcific pancreatitis presenting as kwashiorkor. (15912980)
2004
25
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. (12360463)
2002
26
Prospective study of pancreatic b-cell and exocrine function following duct decompression in tropical calcific pancreatitis. (11865345)
2002
27
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. (12011155)
2002
28
Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. (11151920)
2000
29
Tropical calcific pancreatitis and fibrocalculus pancreatic diabetes in Bangladesh. (9195412)
1997
30
Beta-cell function and insulin sensitivity in tropical calcific pancreatitis from north India. (9109851)
1997
31
Celiac disease and tropical calcific pancreatitis. (8213729)
1993
32
Diabetes secondary to tropical calcific pancreatitis. (1445168)
1992
33
Clinical and biochemical studies in the prediabetic phase of tropical calcific pancreatitis. (1557337)
1992
34
The spectrum of pancreatic exocrine and endocrine (beta-cell) function in tropical calcific pancreatitis. (2205529)
1990
35
Tropical calcific pancreatitis. (7266409)
1980

Variations for Tropical Calcific Pancreatitis

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UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

67
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Tropical Calcific Pancreatitis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Tropical Calcific Pancreatitis

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Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

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GO Terms for genes affiliated with Tropical Calcific Pancreatitis

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Cellular components related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.0ACE, CTSB, PRSS2

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.8CTSB, PRSS2
2vitamin metabolic processGO:00067669.5CTRC, PRSS1
3extracellular matrix disassemblyGO:00226179.2CTSB, PRSS1, PRSS2

Sources for Tropical Calcific Pancreatitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet