MCID: TRP008
MIFTS: 27

Tropical Calcific Pancreatitis malady

Endocrine diseases category

Summaries for Tropical Calcific Pancreatitis

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46OMIM, 32MalaCards
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MalaCards: Tropical Calcific Pancreatitis is related to pancreatitis and alcoholic pancreatitis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Immune response Bacterial infections in normal airways and Degradation of the extracellular matrix. The compounds 2-Phenylethylamine and 3-Phenylpropylamine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Description from OMIM:46 608189

Aliases & Classifications for Tropical Calcific Pancreatitis

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Sources:
46OMIM, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

tropical calcific pancreatitis 46 60


Related Diseases for Tropical Calcific Pancreatitis

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17GeneCards, 18GeneDecks
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Diseases related to Tropical Calcific Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.4PRSS1, SPINK1
2alcoholic pancreatitis30.2CFTR, SPINK1
3cystic fibrosis30.2PRSS1, SPINK1, CFTR
4adenocarcinoma30.2SPINK1, REG1A, PRSS1, CTSB
5kwashiorkor10.2
6celiac disease10.2
7pancreas adenocarcinoma10.2
8fibrocalculous pancreatic diabetes10.2
9arthritis10.0CTSB
10cervical cancer10.0SPINK1
11hypokalemia10.0ACE
12sarcoidosis10.0ACE
13familial adenomatous polyposis10.0TCF7L2
14hereditary pancreatitis10.0PRSS1, SPINK1
15nephritis10.0ACE
16liver cirrhosis10.0REG1A
17steatorrhea10.0CFTR
18polycystic kidney disease10.0CFTR
19angioedema10.0ACE
20gingival overgrowth10.0CTSB
21sinusitis10.0CFTR
22alzheimer's disease10.0REG1A, CTSB
23recurrent acute pancreatitis10.0SPINK1, CFTR
24prostate cancer10.0SPINK1, TCF7L2, CTSB
25stomach cancer10.0CTSB, TCF7L2, SPINK1
26polycystic kidney disease, autosomal dominant10.0ACE, CFTR
27chronic kidney failure10.0CTSB, REG1A, ACE
28cork-handlers' disease10.0ACE, CFTR
29rheumatoid arthritis10.0CFTR, PRSS2, CTSB
30pancreas disease10.0REG1A, SPINK1, CFTR
31colorectal cancer10.0TCF7L2, REG1A, CTSB
32hepatocellular carcinoma10.0REG1A, SPINK1, TCF7L2
33type 2 diabetes mellitus10.0CTSB, ACE, SPINK1, TCF7L2
34hypertrophy of breast10.0ACE, CFTR, CTSB
35adenoma10.0SPINK1, CTSB, REG1A, TCF7L2
36diabetes mellitus10.0TCF7L2, REG1A, ACE, SPINK1
37breast cancer10.0CFTR, TCF7L2, CTSB
38pneumonia10.0CTSB, CFTR
39pancreatitis, chronic10.0PRSS1, SPINK1, CFTR, REG1A
40pancreatic cancer10.0CFTR, SPINK1, REG1A, PRSS1
41primary hyperoxaluria10.0ACE, REG1A, CFTR
42lung cancer10.0TCF7L2, CFTR, CTSB, SPINK1
43acute pancreatitis10.0CFTR, CTSB, SPINK1, PRSS2, REG1A
44colon cancer10.0CTSB, REG1A, CFTR, TCF7L2, SPINK1

Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to tropical calcific pancreatitis

Clinical Features for Tropical Calcific Pancreatitis

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Sources:
46OMIM
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Clinical features from OMIM:

608189

Drugs & Therapeutics for Tropical Calcific Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Tropical Calcific Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Tropical Calcific Pancreatitis

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Search CenterWatch for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

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Anatomical Context for Tropical Calcific Pancreatitis

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Animal Models for Tropical Calcific Pancreatitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2REG1A, CFTR, TCF7L2, ACE, SPINK1, CTSB
2MP:00053796.9SPINK1, ACE, TCF7L2, CFTR, REG1A, CTSB

Publications for Tropical Calcific Pancreatitis

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Genetic Variations for Tropical Calcific Pancreatitis

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Tropical Calcific Pancreatitis:

62
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Expression for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
53Reactome, 52R&D Systems, 29KEGG
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Pathways related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
9.4CFTR, CTSB
2
Hide members
9.3PRSS1, PRSS2, CTSB
3
Hide members
9.3PRSS1, PRSS2, CTSB
49.2CTSB, ACE
59.1CFTR, PRSS1, PRSS2

Compounds for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
11DrugBank, 44Novoseek, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
12-Phenylethylamine1110.0PRSS2, PRSS1
23-Phenylpropylamine1110.0PRSS2, PRSS1
3Monoisopropylphosphorylserine1110.0PRSS1, PRSS2
4Phosphorylisopropane1110.0PRSS1, PRSS2
5benzylamine44 1110.9PRSS1, PRSS2
6benzamidine44 1110.9PRSS1, PRSS2
7fluoride449.5SPINK1, CFTR
8Phosphonoserine119.5REG1A, CFTR
9serine449.2SPINK1, PRSS1, CTSB, CTRC
10kininogen449.2ACE, CTSB
11felodipine44 28 1111.1ACE, CFTR
12sildenafil44 49 28 11 2413.1CFTR, ACE
13glucose448.7TCF7L2, REG1A, CTSB
14cysteine448.5CTSB, PRSS2, PRSS1, CFTR
15trypsinogen447.7SPINK1, CTRC, CTSB, PRSS2, PRSS1, REG1A
16calcium44 49 11 2410.4CTRC, CTSB, PRSS2, PRSS1, REG1A, ACE

GO Terms for genes affiliated with Tropical Calcific Pancreatitis

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Sources:
16Gene Ontology
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Cellular components related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4ACE, PRSS1, PRSS2, CTSB
2extracellular regionGO:0055767.3SPINK1, CTSB, PRSS2, PRSS1, REG1A, ACE

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.7PRSS1, PRSS2
2extracellular matrix disassemblyGO:0226179.2CTSB, PRSS2, PRSS1
3extracellular matrix organizationGO:0301989.0PRSS1, PRSS2, CTSB
4proteolysisGO:0065088.1ACE, PRSS1, PRSS2, CTSB, CTRC

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.6CTSB, CTRC
2serine-type endopeptidase activityGO:0042529.0PRSS1, PRSS2, CTRC

Products for genes affiliated with Tropical Calcific Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tropical Calcific Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet