MCID: TRP002
MIFTS: 55

Tropical Spastic Paraparesis malady

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tropical Spastic Paraparesis

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Aliases & Descriptions for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 11 47 13 66
Paraparesis, Tropical Spastic 37
Paraparesis Tropical Spastic 48
 
Tropical Spastic Paraplegia 11
Htlv-Associated Myelopathy 11
Tropical Spastic Paralysis 11

Classifications:



External Ids:

Disease Ontology11 DOID:321
ICD1028 G04.1
MeSH37 D015493

Summaries for Tropical Spastic Paraparesis

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Disease Ontology:11 A viral infectious disease that results in inflammation located in spinal cord, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. the infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards based summary: Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to systemic lupus erythematosus and htlv-1 associated myelopathy/tropical spastic paraparesis, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is IL2 (Interleukin 2), and among its related pathways are Osteopontin Signaling and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are liver/biliary system and neoplasm.

NINDS:47 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:69 Tropical spastic paraparesis (TSP), also called HTLV-I-Associated Myelopathy (HAM) or HTLV-I-Associated... more...

Related Diseases for Tropical Spastic Paraparesis

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Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus28.3CXCR3, GATA3, IFNG, IL10, IL2, IL6
2htlv-1 associated myelopathy/tropical spastic paraparesis12.6
3myelopathy, htlv-1-associated11.9
4spastic paraparesis11.3
5spasticity11.3
6human t-cell leukemia virus type 110.9
7eye accommodation disease10.7IFNG, IL10
8leukemia10.7
9t-cell leukemia10.7
10thelaziasis10.7IFNG, IL10
11bulbospinal polio10.7IFNG, IL2
12pediatric t-cell leukemia10.6IL10, IL2
13predominantly cortical thymoma10.6IL10, IL6
14panner disease10.6IFNG, IL6
15anthracosilicosis10.6IFNG, IL2
16benign adult familial myoclonic epilepsy10.6IL10, IL6
17addison's disease10.6IFNG, IL10, IL2
18thomsen and becker disease10.6IFNG, IL2
19maligant granulosa cell tumor of ovary10.6IL2, IL6
20lipodermatosclerosis10.6IFNG, IL10, IL2
21calcifying epithelial odontogenic tumor10.5IFNG, IL10, IL2
22pneumonic tularemia10.5IFNG, IL10, IL2
23gonococcal synovitis10.5IFNG, MMP9
24collagen disease10.5IFNG, IL10, IL2
25hypospadias10.5IFNG, IL10, IL2
26subendocardial infarction acute myocardial infarction10.5IFNG, IL10, IL2
27midline interhemispheric variant of holoprosencephaly10.5IL2, IL6
28infancy electroclinical syndrome10.5IL10, IL6
29dengue disease10.5IFNG, IL10, IL2
30herpangina10.5IFNG, IL10, IL6
31idiopathic neutropenia10.5IFNG, IL10, IL6
32adult t-cell leukemia10.5
33orbital lymphangioma10.5IFNG, IL10, IL6
34hereditary conventional renal cell carcinoma10.5IFNG, IL10, IL2
35variola minor10.5IFNG, IL10, IL2
36scn8a encephalopathy10.5IFNG, IL10, IL6
37mastocytosis cutaneous with short stature conductive hearing loss and microtia10.5IFNG, IL10, IL6
38hemophagocytic lymphohistiocytosis10.5IFNG, IL10, IL6
39polycystic ovary syndrome10.5IL2, NFKB1
40leukostasis10.5IFNG, IL10, IL6
41dementia - subcortical10.5IFNG, IL10, IL6
42marchiafava bignami disease10.5IL10, IL6, MMP9
43oesophagostomiasis10.5IFNG, IL10, IL6
44ethmoid sinus adenoid cystic carcinoma10.5IL10, IL6
45gastric dilatation10.5IFNG, IL10, IL6
46bile duct signet ring cell carcinoma10.5IFNG, IL10, IL6
47uterine corpus dissecting leiomyoma10.5IFNG, IL10, IL2
48orbital periostitis10.5IFNG, IL10, IL6
49corneal intraepithelial neoplasm10.5IFNG, IL10, IL6
50melioidosis10.5IFNG, IL10, IL6

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Symptoms for Tropical Spastic Paraparesis

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Symptoms:

 11
  • s
  • m

UMLS symptoms related to Tropical Spastic Paraparesis:


hemiparesis, hemiplegia, paresis, paraparesis, todd paralysis, quadriparesis, monoparesis, paresis anal sphincter

Drugs & Therapeutics for Tropical Spastic Paraparesis

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Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Valproic AcidPhase 331899-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propyl-pentanoic acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VPA
Valcote
Valparin
Valproate
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
acide valproïque
acidum valproicum
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
ácido valproico
2
LamivudinePhase 2, Phase 3605134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
 
DB00709
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
3
PentoxifyllinePhase 3936493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
4
MiconazolePhase 2, Phase 3357322916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
5
ZidovudinePhase 2, Phase 3, Phase 049530516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
 
CPD000058351
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
6interferonsPhase 22112
7
Interferon beta-1aPhase 2195145258-61-36438354
Synonyms:
145258-61-3
Avonex
Avonex (TN)
Belerofon
D04554
 
Fibroblast interferon
IFN-beta
Interferon beta precursor
Interferon beta-1a
Interferon beta-1a (USAN)
Interferon beta-1a (genetical recombination)
Interferon beta-1a (genetical recombination) (JAN)
8
infliximabPhase 2364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialCompletedNCT00272480Phase 2, Phase 3
2Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)CompletedNCT00773292Phase 2, Phase 3
3Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesCompletedNCT01472263Phase 3
4Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)CompletedNCT00681980Phase 3
5Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)Active, not recruitingNCT01343355Phase 2, Phase 3
6Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)CompletedNCT00001785Phase 2
7The HAM Infliximab StudyTerminatedNCT00823641Phase 2
8Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisRecruitingNCT00076843Phase 1
9MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic ParaparesisCompletedNCT00034723
10A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective DermatitisCompletedNCT00340821
11Assessment of Patients With Multiple Sclerosis (MS)CompletedNCT00001156
12Evaluation of Patients With HAM/TSPRecruitingNCT00001778
13Raltegravir for HAM/TSPRecruitingNCT01867320Phase 0
14Urological Physical Therapy in HTLV-1 With Urinary SymptomsEnrolling by invitationNCT01651819
15Evaluation of the MP Diagnostics HTLV Blot 2.4Enrolling by invitationNCT01467024
16Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionNot yet recruitingNCT02655471Phase 0
17Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1Not yet recruitingNCT01754311
18Safety and Efficiency Study of Valproic Acid In HAM/TSPTerminatedNCT00519181

Search NIH Clinical Center for Tropical Spastic Paraparesis


Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

34
T cells, Spinal cord, Breast, Brain, Testes, B cells, Nk cells

FMA organs/tissues related to Tropical Spastic Paraparesis:

17
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

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MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

39 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4B2M, IFNG, IL10, IL2, IL6, NFKB1
2MP:00020067.9B2M, CXCR3, IFNG, IL10, IL2, IL6
3MP:00053797.9B2M, GATA3, IFNG, IL10, IL2, IL6
4MP:00053887.8CXCR3, IFNG, IL10, IL2, IL6, MMP9
5MP:00053917.7CX3CR1, GATA3, IFNG, IL10, IL6, MMP9
6MP:00053897.7B2M, CX3CR1, GATA3, IFNG, IL10, IL2
7MP:00053677.5CX3CR1, CXCR3, GATA3, IFNG, IL6, MMP9
8MP:00028737.4CX3CR1, CXCR3, GATA3, IFNG, IL10, NFKB1
9MP:00053817.4B2M, CX3CR1, IFNG, IL10, IL2, IL6
10MP:00107717.3B2M, CX3CR1, GATA3, IFNG, IL10, IL6
11MP:00036316.7B2M, CNTN2, CX3CR1, GATA3, IFNG, IL10
12MP:00053856.6B2M, CX3CR1, CXCR3, GATA3, IFNG, IL10
13MP:00107685.9B2M, CX3CR1, CXCR3, GATA3, IFNG, IL10
14MP:00053785.8B2M, CX3CR1, GATA3, IFNG, IL10, IL2
15MP:00053765.7B2M, CX3CR1, CXCR3, GATA3, IFNG, IL10
16MP:00053845.7B2M, CX3CR1, CXCR3, GATA3, IFNG, IL10
17MP:00053875.4B2M, CX3CR1, CXCR3, GATA3, IFNG, IFNL3
18MP:00053975.3B2M, CX3CR1, CXCR3, GATA3, IFNG, IFNL3

Publications for Tropical Spastic Paraparesis

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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. (26472535)
2015
2
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (26174324)
2015
3
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. (25760424)
2015
4
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. (26241614)
2015
5
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. (25229227)
2014
6
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
7
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (23651542)
2013
8
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. (23568138)
2013
9
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
10
Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. (22460962)
2012
11
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
12
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. (20572090)
2010
13
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
14
Low risk of tropical spastic paraparesis/human T lymphotropic virus type 1-associated myelopathy development among persons aged >50 years. (18680397)
2008
15
Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. (19040291)
2008
16
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. (18691139)
2008
17
Human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in an HIV-positive patient coinfected with human T lymphotropic virus type 2 following initiation of antiretroviral therapy. (17918071)
2007
18
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
19
Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state. (16879249)
2006
20
Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)
2005
21
A cluster of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Jujuy, Argentina. (12640204)
2003
22
Osteoporosis in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (14499352)
2003
23
Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis. (13129766)
2003
24
Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (11959151)
2002
25
Tropical spastic paraparesis. (11928898)
2001
26
Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)
1999
27
On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. (10460931)
1999
28
Clinical evolution of tropical spastic paraparesis: The Tumaco experience. (16873192)
1999
29
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
30
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
31
Study of lower limb somatosensory evoked potentials in 96 cases of HTLV-I-associated myelopathy/tropical spastic paraparesis. (8791242)
1996
32
Multiple sclerosis and HTLV-I associated myelopathy/tropical spastic paraparesis are two distinct clinical entities. (9345386)
1996
33
Nucleotide sequences of human T-lymphotropic virus type I (HTLV-I) from a family cluster with tropical spastic paraparesis/HTLV-I-associated myelopathy. (7638441)
1995
34
Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. (7847858)
1995
35
Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy. (7884912)
1995
36
Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica. (7485068)
1995
37
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
38
HTLV-1 infection and tropical spastic paraparesis in Esmeraldas Province of Ecuador. (7570816)
1994
39
Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis. (8489210)
1993
40
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
41
A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. (1402668)
1992
42
Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an asymptomatic carrier to rabbits. (1712582)
1991
43
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
44
High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. (1967218)
1990
45
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
46
Neuroepidemiology of human T-lymphotrophic virus type-I-associated tropical spastic paraparesis. (2786158)
1989
47
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988
48
Immunological findings in neurological diseases associated with antibodies to HTLV-I: activated lymphocytes in tropical spastic paraparesis. (2894814)
1988
49
Treponematoses and tropical spastic paraparesis. (2870309)
1986
50
Tropical spastic paraparesis. (3729320)
1986

Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

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Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathwaysScoreTop Affiliating Genes
19.8MMP9, NFKB1
2
Show member pathways
9.7IFNG, IL10, IL2
39.6IFNG, IL10, IL6
49.6IFNG, IL10, IL6
59.6IFNG, IL2, NFKB1
69.5IL10, IL6, NFKB1
79.5IL10, IL6, NFKB1
89.5IFNG, IL6, NFKB1
9
Show member pathways
9.5IFNG, IL6, NFKB1
10
Show member pathways
9.5IFNG, IL6, NFKB1
119.4IL6, MMP9, NFKB1
129.4IL6, MMP9, NFKB1
139.4IL6, MMP9, NFKB1
14
Show member pathways
9.4GATA3, IFNG, IL2
15
Show member pathways
9.3IFNG, IL10, IL2, IL6
169.3IFNG, IL10, IL2, IL6
179.3IFNG, IL10, IL2, IL6
18
Show member pathways
9.3IFNG, IL10, IL2, IL6
19
Show member pathways
9.3IFNG, IL10, IL2, NFKB1
209.3IFNG, IL2, IL6, MMP9
219.2IFNG, IL2, IL6, NFKB1
229.2IFNG, IL10, IL6, NFKB1
239.2IFNG, IL10, IL6, NFKB1
249.1IFNG, IL6, MMP9, NFKB1
259.1IL10, IL6, NFKB1, TNFRSF4
26
Show member pathways
9.0IFNG, IFNL3, IL10, IL2, IL6
279.0GATA3, IL10, IL6, NFKB1
28
Show member pathways
8.9IFNG, IL10, IL2, IL6, NFKB1
29
Show member pathways
8.9B2M, IFNG, IL2, NFKB1
30
Show member pathways
8.9B2M, IFNG, IL2, TNFRSF4
318.9IFNG, IL10, IL2, NFKB1, TNFRSF4
328.8CX3CR1, IFNG, IL10, IL2, IL6
338.8CX3CR1, IFNG, IL10, IL2, IL6
34
Show member pathways
8.8GATA3, IFNG, IL10, IL2, IL6
358.7GATA3, IFNG, IL10, IL2, TNFRSF4
368.7GATA3, IFNG, IL2, IL6, NFKB1
37
Show member pathways
8.6IFNG, IL10, IL2, IL6, MMP9, NFKB1
38
Show member pathways
8.4GATA3, IFNG, IL10, IL2, IL6, NFKB1
398.3CXCR3, GATA3, IFNG, IL10, IL2
40
Show member pathways
7.8B2M, GATA3, IFNG, IL10, IL2, IL6
417.7B2M, GATA3, IFNG, IL10, IL2, NFKB1
42
Show member pathways
7.5CX3CR1, CXCR3, IL10, IL2, IL6, NFKB1
43
Show member pathways
7.0CX3CR1, CXCR3, IL10, IL2, IL6, NFKB1
44
Show member pathways
6.9CX3CR1, CXCR3, IFNG, IFNL3, IL10, IL2

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6B2M, CXCR3, IFNG, IL6
2neuron projectionGO:00430058.6CNTN2, CX3CR1, IFNG, NFKB1, PTPN13
3extracellular spaceGO:00056157.8B2M, IFNG, IFNL3, IL10, IL2, IL6

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1neutrophil apoptotic processGO:000178110.6IFNG, IL6
2positive regulation of isotype switching to IgG isotypesGO:004830410.5IFNG, IL2
3positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL10
4negative regulation of growth of symbiont in hostGO:004413010.4IFNG, IL10
5cellular response to hepatocyte growth factor stimulusGO:003572910.4IL10, IL6
6positive regulation of T cell differentiationGO:004558210.3GATA3, IL2
7positive regulation of receptor bindingGO:190012210.2B2M, MMP9
8positive regulation of immunoglobulin secretionGO:005102410.2IL2, IL6, TNFRSF4
9defense response to protozoanGO:004283210.1IFNG, IL10, IL6
10response to molecule of bacterial originGO:000223710.1B2M, IL10
11humoral immune responseGO:00069599.9GATA3, IFNG, IL6
12positive regulation of T cell proliferationGO:00421029.9IFNG, IL2, IL6
13cellular response to tumor necrosis factorGO:00713569.7GATA3, IL6, NFKB1
14negative regulation of inflammatory responseGO:00507289.6GATA3, IL10, IL2, NFKB1
15negative regulation of apoptotic processGO:00430669.0IL10, IL2, IL6, MMP9, NFKB1
16positive regulation of transcription, DNA-templatedGO:00458938.9GATA3, IFNG, IL10, IL6, NFKB1
17inflammatory responseGO:00069548.6CXCR3, IL10, IL6, NFKB1, TNFRSF4
18cellular response to lipopolysaccharideGO:00712228.5B2M, CX3CR1, IFNG, IL10, IL6, NFKB1
19positive regulation of transcription from RNA polymerase II promoterGO:00459448.4GATA3, IFNG, IL10, IL2, IL6, NFKB1
20response to drugGO:00424938.1B2M, GATA3, IFNG, IL10, IL6

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor bindingGO:000513410.2GATA3, IL2
2chemokine receptor activityGO:00049509.1CX3CR1, CXCR3
3cytokine activityGO:00051258.7IFNG, IFNL3, IL10, IL2, IL6

Sources for Tropical Spastic Paraparesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet