MCID: TRP002
MIFTS: 61

Tropical Spastic Paraparesis malady

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Immune diseases

Aliases & Classifications for Tropical Spastic Paraparesis

About this section
Sources:
10Disease Ontology, 46NINDS, 12DISEASES, 51Orphanet, 65UMLS, 47Novoseek, 36MeSH, 27ICD10, 59SNOMED-CT, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 10 46 12 51 65
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/tropical Spastic Paraparesis 51
Human T-Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis 51
Htlv-1-Associated Myelopathy/tropical Spastic Paraparesis 51
Paraparesis, Tropical Spastic 36
Paraparesis Tropical Spastic 47
 
Tropical Spastic Paraplegia 10
Tropical Spastic Paralysis 10
Htlv-Associated Myelopathy 10
Ham/tsp 51
Tsp 51

Characteristics:

Orphanet epidemiological data:

51
tropical spastic paraparesis:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:321
ICD1027 G04.1
MeSH36 D015493
SNOMED-CT59 192733005, 45129002
Orphanet51 289326
ICD10 via Orphanet28 G04.1
UMLS via Orphanet66 C0030481
UMLS65 C0030481

Summaries for Tropical Spastic Paraparesis

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Disease Ontology:10 A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards based summary: Tropical Spastic Paraparesis, also known as human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis, is related to psoriasis and neurogenic bladder, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways are Osteopontin Signaling and Spinal Cord Injury. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are respiratory system and digestive/alimentary.

NINDS:46 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:68 Tropical spastic paraparesis (TSP) is a medical condition that causes weakness, muscle spasms, and... more...

Related Diseases for Tropical Spastic Paraparesis

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Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis31.0HLA-A, HLA-B
2neurogenic bladder30.3IFNG, IL10, IL2
3systemic lupus erythematosus29.3IFNG, IL10, IL2, IL2RA, MMP9
4htlv-1 associated myelopathy/tropical spastic paraparesis12.6
5htlv-1 associated myelopathy11.8
6spastic paraparesis11.3
7spasticity11.3
8human t-cell leukemia virus type 110.9
9periventricular leukomalacia10.8HLA-A, HLA-B
10postinfectious encephalomyelitis10.8HLA-A, HLA-B
11iridocyclitis10.7HLA-A, HLA-B
12retinitis10.7HLA-A, HLA-B
13leukemia10.7
14anthracosis10.7HLA-A, HLA-B
15t-cell leukemia10.7
16undetermined early-onset epileptic encephalopathy10.7HLA-A, HLA-B
17intermediate uveitis10.7HLA-A, HLA-B
18acneiform dermatitis10.7HLA-A, HLA-B
19prostate malignant phyllodes tumor10.7HLA-A, HLA-B
20acquired thrombocytopenia10.7HLA-A, HLA-B
21subcorneal pustular dermatosis10.7HLA-A, HLA-B
22lacrimal duct obstruction10.6HLA-A, HLA-B
23human herpesvirus 810.6HLA-A, HLA-B
24spinal polio10.6IFNG, IL2
25limbic encephalitis with ncmags antibodies10.6IFNG, IL2
26gonococcal iridocyclitis10.6HLA-A, HLA-B
27hydromyelia10.6CNTN2, HLA-A, HLA-B
28exostosis10.5HLA-A, IFNG
29chronic hiccups10.5IFNG, IL2RA
30baylisascariasis10.5IL2, MMP9
31human t-cell leukemia virus type 310.5CNTN2, NFKB1
32pulmonary nodular lymphoid hyperplasia10.5HLA-A, HLA-B, IFNG
33cryptosporidiosis10.5HLA-A, HLA-B, IFNG
34epididymis cancer10.5IL2, MMP9
35adult t-cell leukemia10.5
36artemis deficiency10.5HLA-A, HLA-B, IFNG
37dioctophymiasis10.5IFNG, IL10
38dermatitis10.5
39root resorption10.5HLA-A, HLA-B, IL2RA
40alcohol-induced mental disorder10.5HLA-A, HLA-B, MMP9
41malignant cardiac peripheral nerve sheath neoplasm10.5HLA-A, HLA-B, IL2RA
42cd45 deficiency10.5IL2, IL2RA
43estrogen excess10.4HLA-A, HLA-B
44angioid streaks10.4HLA-A, IL2, IL2RA
45kernicterus due to isoimmunization10.4HLA-A, HLA-B, IL10
46placental abruption10.4HLA-A, HLA-B, IL10
47lymphoma10.4
48disseminated chorioretinitis10.4HLA-A, HLA-B, IL10
49retinal drusen10.4IL2, IL2RA
50opisthorchiasis10.4IFNG, IL10

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Symptoms for Tropical Spastic Paraparesis

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Symptoms:

 10
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

UMLS symptoms related to Tropical Spastic Paraparesis:


paresis anal sphincter, monoparesis, quadriparesis, todd paralysis, paraparesis, paresis, hemiplegia, hemiparesis

Drugs & Therapeutics for Tropical Spastic Paraparesis

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Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pentoxifyllineapproved, investigationalPhase 3906493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
2
Miconazoleapproved, investigationalPhase 2, Phase 3302622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3
Lamivudineapproved, investigationalPhase 2, Phase 3594134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3-TC
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
DB00709
 
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir HBV
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714 X
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
4
ZidovudineapprovedPhase 2, Phase 3, Phase 049130516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
CPD000058351
 
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
5
Valproic Acidapproved, investigationalPhase 331199-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-PROPYL-pentanoic acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Depakote ER
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaeure
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VALPROIC acid
VPA
Valcote
Valparin
Valproate
Valproate Semisodium
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic
Valproic Acid
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
6Radiation-Protective AgentsPhase 3333
7Anti-Infective AgentsPhase 2, Phase 3, Phase 017220
8Phosphodiesterase InhibitorsPhase 31062
9Vasodilator AgentsPhase 32926
10Platelet Aggregation InhibitorsPhase 31935
11AnticonvulsantsPhase 32249
12Neurotransmitter AgentsPhase 314795
13Central Nervous System DepressantsPhase 310016
14Tranquilizing AgentsPhase 33597
15Antimanic AgentsPhase 3663
16Psychotropic DrugsPhase 35501
17Protective AgentsPhase 35651
18Nucleic Acid Synthesis InhibitorsPhase 2, Phase 3, Phase 03836
19Reverse Transcriptase InhibitorsPhase 2, Phase 3, Phase 01656
20Antiviral AgentsPhase 2, Phase 3, Phase 08071
21Anti-Retroviral AgentsPhase 2, Phase 3, Phase 02794
22AntioxidantsPhase 32442
23Antifungal AgentsPhase 2, Phase 33015
24AntimetabolitesPhase 2, Phase 3, Phase 09454
25Immunosuppressive AgentsPhase 2, Phase 310422
26Antirheumatic AgentsPhase 2, Phase 38496
27Dermatologic AgentsPhase 2, Phase 34555
28Immunologic FactorsPhase 2, Phase 318483
29Calcineurin InhibitorsPhase 2, Phase 31223
30CyclosporinsPhase 2, Phase 3873
31
Interferon beta-1aapproved, investigationalPhase 2194145258-61-36438354
Synonyms:
145258-61-3
Avonex
Avonex (TN)
Avonex Pen
Belerofon
D04554
Extavia
 
Fibroblast interferon
IFN-beta
Interferon beta precursor
Interferon beta-1a
Interferon beta-1a (USAN)
Interferon beta-1a (genetical recombination)
Interferon beta-1a (genetical recombination) (JAN)
Rebif
Rebif Rebidose
32
InfliximabapprovedPhase 2349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
33interferonsPhase 21930
34Interferon-betaPhase 2253
35Adjuvants, ImmunologicPhase 21783
36Gastrointestinal AgentsPhase 26401
37ImmunoglobulinsPhase 14477
38Antibodies, MonoclonalPhase 12413
39AntibodiesPhase 14477
40Raltegravir PotassiumPhase 0288
41HIV Integrase InhibitorsPhase 0343
42Integrase InhibitorsPhase 0370

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialCompletedNCT00272480Phase 2, Phase 3
2Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)CompletedNCT00773292Phase 2, Phase 3
3Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesCompletedNCT01472263Phase 3
4Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)CompletedNCT00681980Phase 3
5Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)Active, not recruitingNCT01343355Phase 2, Phase 3
6Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)CompletedNCT00001785Phase 2
7The HAM Infliximab StudyTerminatedNCT00823641Phase 2
8Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisRecruitingNCT00076843Phase 1
9MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic ParaparesisCompletedNCT00034723
10A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective DermatitisCompletedNCT00340821
11Assessment of Patients With Multiple Sclerosis (MS)CompletedNCT00001156
12Evaluation of Patients With HAM/TSPRecruitingNCT00001778
13Raltegravir for HAM/TSPRecruitingNCT01867320Phase 0
14Urological Physical Therapy in HTLV-1 With Urinary SymptomsEnrolling by invitationNCT01651819
15Evaluation of the MP Diagnostics HTLV Blot 2.4Enrolling by invitationNCT01467024
16Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionNot yet recruitingNCT02655471Phase 0
17Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1Not yet recruitingNCT01754311
18Safety and Efficiency Study of Valproic Acid In HAM/TSPTerminatedNCT00519181

Search NIH Clinical Center for Tropical Spastic Paraparesis


Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

33
T cells, Spinal cord, Breast, Prostate, Heart, Lung, Brain

FMA organs/tissues related to Tropical Spastic Paraparesis:

16
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

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MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7IFNG, IL10, IL2, MMP9, NFKB1, TNFRSF4
2MP:00053817.5CX3CR1, IFNG, IL10, IL2, IL2RA, MMP9
3MP:00053786.8CX3CR1, IFNG, IL10, IL2, IL2RA, MMP9
4MP:00053976.8CX3CR1, IFNG, IL10, IL2, IL2RA, MMP9
5MP:00053876.5CX3CR1, IFNG, IL10, IL2, IL2RA, MMP9

Publications for Tropical Spastic Paraparesis

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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (26756420)
2016
2
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. (26472535)
2015
3
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. (25229227)
2014
4
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
5
Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine). (23477875)
2013
6
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (23651542)
2013
7
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
8
Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. (22460962)
2012
9
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
10
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
11
Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders. (21851845)
2011
12
Characteristics of Chronic Pain and Its Impact on Quality of Life of Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20842011)
2011
13
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
14
Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients. (18205234)
2008
15
Low risk of tropical spastic paraparesis/human T lymphotropic virus type 1-associated myelopathy development among persons aged >50 years. (18680397)
2008
16
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
17
Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. (19040291)
2008
18
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. (18691139)
2008
19
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
20
Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)
2005
21
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
22
A cluster of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Jujuy, Argentina. (12640204)
2003
23
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
24
Tropical spastic paraparesis. (11928898)
2001
25
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. (10967179)
2000
26
Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)
1999
27
On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. (10460931)
1999
28
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
29
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
30
Nucleotide sequences of human T-lymphotropic virus type I (HTLV-I) from a family cluster with tropical spastic paraparesis/HTLV-I-associated myelopathy. (7638441)
1995
31
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives. (8563108)
1995
32
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
33
Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. (7703492)
1995
34
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
35
HTLV-1 infection and tropical spastic paraparesis in Esmeraldas Province of Ecuador. (7570816)
1994
36
Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey. (8345613)
1993
37
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. (8213080)
1993
38
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
39
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
40
A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. (1402668)
1992
41
Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an asymptomatic carrier to rabbits. (1712582)
1991
42
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
43
Tropical spastic paraparesis and HTLV-I myelopathy: clinical features and pathogenesis. (2183307)
1990
44
High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. (1967218)
1990
45
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
46
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
47
HTLV-1 associated tropical spastic paraparesis in an African patient residing in Belgium. (2730175)
1989
48
Neuroepidemiology of human T-lymphotrophic virus type-I-associated tropical spastic paraparesis. (2786158)
1989
49
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
50
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988

Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

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Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 39)    (show all 40)
idSuper pathwaysScoreTop Affiliating Genes
19.8MMP9, NFKB1
29.7IFNG, IL2, MMP9
3
Show member pathways
9.7IFNG, IL2, IL2RA
4
Show member pathways
9.7IFNG, IL2, IL2RA
59.7IFNG, IL2, IL2RA
69.7IFNG, IL2, IL2RA
79.6IFNG, IL10, IL2
8
Show member pathways
9.6IFNG, IL10, IL2
99.5IFNG, IL2, NFKB1
109.5IFNG, IL2, NFKB1
119.5IFNG, IL2, NFKB1
12
Show member pathways
9.5IL2, IL2RA, NFKB1
13
Show member pathways
9.5IL2, IL2RA, NFKB1
14
Show member pathways
9.5IL2, IL2RA, NFKB1
159.5IFNG, IL10, NFKB1
16
Show member pathways
9.3IFNG, IL10, IL2, IL2RA
179.3IFNG, IL10, IL2, IL2RA
189.3IFNG, IL10, IL2, IL2RA
199.2CNTN2, HLA-A, HLA-B
20
Show member pathways
9.2IFNG, IL10, IL2, NFKB1
21
Show member pathways
9.2IFNG, IL10, IL2, NFKB1
22
Show member pathways
9.0IFNG, IFNL3, IL10, IL2, IL2RA
239.0IL10, IL2RA, NFKB1, TNFRSF4
24
Show member pathways
8.9IFNG, IL10, IL2, MMP9, NFKB1
25
Show member pathways
8.9HLA-A, IFNG, IL2, IL2RA, NFKB1
268.9IFNG, IL10, IL2, IL2RA, TNFRSF4
27
Show member pathways
8.8HLA-A, IFNG, IL2, IL2RA, TNFRSF4
288.8CX3CR1, IFNG, IL10, IL2
298.7IFNG, IL10, IL2, NFKB1, TNFRSF4
30
Show member pathways
8.6HLA-A, HLA-B, IFNG, IL10, IL2
318.5HLA-A, HLA-B, IL2, IL2RA, NFKB1
328.5CX3CR1, IFNG, IL10, IL2, IL2RA
338.5HLA-A, HLA-B, IFNG, IL10, NFKB1
34
Show member pathways
8.4HLA-A, HLA-B, IFNG, IL2, KIR2DL2
35
Show member pathways
8.2HLA-A, HLA-B, IFNG, IL2, IL2RA, NFKB1
36
Show member pathways
7.4HLA-A, HLA-B, IFNG, IL10, IL2, IL2RA
37
Show member pathways
7.4CX3CR1, IL10, IL2, IL2RA, NFKB1, PTPN13
38
Show member pathways
7.3CX3CR1, IFNG, IFNL3, IL10, IL2, IL2RA
39
Show member pathways
6.9HLA-A, HLA-B, IFNG, IFNL3, IL2, IL2RA

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:004601310.6IL2, IL2RA
2defense response to protozoanGO:004283210.5IFNG, IL10
3positive regulation of isotype switching to IgG isotypesGO:004830410.4IFNG, IL2
4negative regulation of T cell proliferationGO:004213010.4IL10, IL2RA
5negative regulation of growth of symbiont in hostGO:004413010.4IFNG, IL10
6positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10
7protection from natural killer cell mediated cytotoxicityGO:004227010.1HLA-A, HLA-B
8positive regulation of T cell mediated cytotoxicityGO:000191610.1HLA-A, HLA-B
9negative regulation of inflammatory responseGO:005072810.0IL10, IL2, IL2RA
10antigen processing and presentationGO:00198829.7HLA-A, HLA-B, IFNG
11interferon-gamma-mediated signaling pathwayGO:00603339.6HLA-A, HLA-B, IFNG
12axon guidanceGO:00074119.4CNTN2, IL2, IL2RA, MMP9
13negative regulation of apoptotic processGO:00430669.3IL10, IL2, MMP9, NFKB1
14immune responseGO:00069558.8IFNG, IL10, IL2, IL2RA, TNFRSF4
15cellular response to lipopolysaccharideGO:00712228.7CX3CR1, IFNG, NFKB1

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.5HLA-A, HLA-B

Sources for Tropical Spastic Paraparesis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet