TSP
MCID: TRP002
MIFTS: 55

Tropical Spastic Paraparesis (TSP) malady

Neuronal diseases, Infectious diseases, Rare diseases, Immune diseases categories

Summaries for Tropical Spastic Paraparesis

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9Disease Ontology, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 A viral infectious disease that results in inflammation located in spinal cord, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. the infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards: Tropical Spastic Paraparesis, also known as human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis, is related to multiple sclerosis and neuropathy, and has symptoms including spasms, sensory disturbance and muscle stiffness. An important gene associated with Tropical Spastic Paraparesis is TNFRSF4 (tumor necrosis factor receptor superfamily, member 4), and among its related pathways are CD28 co-stimulation and Translocation of ZAP-70 to Immunological synapse. The compound ionomycin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are hematopoietic system and cellular.

NINDS:45 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:66 Tropical spastic paraparesis (TSP), also known as HTLV-associated myelopathy or chronic progressive... more...

Description from OMIM:48 159580

Aliases & Classifications for Tropical Spastic Paraparesis

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9Disease Ontology, 45NINDS, 11DISEASES, 46Novoseek, 50Orphanet, 48OMIM, 63UMLS, 59SNOMED-CT, 36MeSH, 64UMLS via Orphanet, 27ICD10 via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
tropical spastic paraparesis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

tropical spastic paraparesis 9 45 11 50 48 63
human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis 50
human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis 50
htlv-1-associated myelopathy/tropical spastic paraparesis 50
paraparesis tropical spastic 46
tropical spastic paraplegia 9
htlv-associated myelopathy 9
tropical spastic paralysis 9
ham/tsp 50
tsp 50


External Ids:

Disease Ontology9 DOID:321
OMIM48 159580
MeSH36 D015493
SNOMED-CT59 192733005, 45129002
UMLS via Orphanet64 C0030481
ICD10 via Orphanet27 G04.1
ICD1026 G04.1

Related Diseases for Tropical Spastic Paraparesis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Symptoms for Tropical Spastic Paraparesis

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48OMIM, 9Disease Ontology
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Symptoms by clinical synopsis from OMIM:

159580

Clinical features from OMIM:

159580

Symptoms:

9
  • spasms
  • sensory disturbance
  • muscle stiffness
  • spastic weakness of both legs

Drugs & Therapeutics for Tropical Spastic Paraparesis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Tropical Spastic Paraparesis

Search CenterWatch for Tropical Spastic Paraparesis

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

34
T cells, Spinal cord, Breast, Testes, Nk cells, Brain, Thyroid, Skeletal muscle, Thymus, B cells

FMA organs/tissues related to Tropical Spastic Paraparesis:

15
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0CD274, KLRK1, PDCD1, CX3CR1, TNFRSF4
2MP:00053848.0TNFRSF4, NEFH, CX3CR1, PDCD1, CD274
3MP:00053877.9TNFRSF4, CX3CR1, PDCD1, KLRK1, CD274
4MP:00036317.8PDCD1, CNTN2, CX3CR1, NEFH, NEFL

Publications for Tropical Spastic Paraparesis

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53PubMed
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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 362)
idTitleAuthorsYear
1
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
2
Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine). (23477875)
2013
3
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (23651542)
2013
4
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
5
Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. (22460962)
2012
6
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
7
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
8
Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders. (21851845)
2011
9
Characteristics of Chronic Pain and Its Impact on Quality of Life of Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20842011)
2011
10
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (19228429)
2009
11
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
12
Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients. (18205234)
2008
13
Low risk of tropical spastic paraparesis/human T lymphotropic virus type 1-associated myelopathy development among persons aged >50 years. (18680397)
2008
14
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
15
Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. (19040291)
2008
16
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. (18691139)
2008
17
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
18
Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)
2005
19
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
20
A cluster of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Jujuy, Argentina. (12640204)
2003
21
Osteoporosis in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (14499352)
2003
22
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
23
Tropical spastic paraparesis. (11928898)
2001
24
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. (10967179)
2000
25
Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)
1999
26
On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. (10460931)
1999
27
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
28
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
29
Nucleotide sequences of human T-lymphotropic virus type I (HTLV-I) from a family cluster with tropical spastic paraparesis/HTLV-I-associated myelopathy. (7638441)
1995
30
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives. (8563108)
1995
31
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
32
Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. (7703492)
1995
33
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
34
HTLV-1 infection and tropical spastic paraparesis in Esmeraldas Province of Ecuador. (7570816)
1994
35
Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey. (8345613)
1993
36
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. (8213080)
1993
37
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
38
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
39
A rat model of human T lymphocyte virus type I (HTLV-I) infection. 1. Humoral antibody response, provirus integration, and HTLV-I-associated myelopathy/tropical spastic paraparesis-like myelopathy in seronegative HTLV-I carrier rats. (1402668)
1992
40
Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an asymptomatic carrier to rabbits. (1712582)
1991
41
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
42
Tropical spastic paraparesis and HTLV-I myelopathy: clinical features and pathogenesis. (2183307)
1990
43
High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. (1967218)
1990
44
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
45
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
46
HTLV-1 associated tropical spastic paraparesis in an African patient residing in Belgium. (2730175)
1989
47
Neuroepidemiology of human T-lymphotrophic virus type-I-associated tropical spastic paraparesis. (2786158)
1989
48
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
49
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988
50
HTLV-I, adult T-cell leukemia, and tropical spastic paraparesis. (2894811)
1988

Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tropical Spastic Paraparesis

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Pathways for genes affiliated with Tropical Spastic Paraparesis

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51PathCards, 56Reactome, 54QIAGEN, 13EMD Millipore, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Tropical Spastic Paraparesis

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46Novoseek
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Compounds related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ionomycin469.3CD274, CNTN2, TNFRSF4

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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17Gene Ontology
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Cellular components related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2CD274, PDCD1, TNFRSF4
2neurofilamentGO:0058839.0NEFH, NEFL

Biological processes related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule cytoskeleton organizationGO:0002269.6CNTN2, NEFH
2T cell costimulationGO:0312959.5CD274, PDCD1
3cellular defense responseGO:0069689.3CX3CR1, TNFRSF4
4neurofilament bundle assemblyGO:0336939.3NEFH, NEFL

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3NEFH, NEFL
2protein binding, bridgingGO:0306749.0NEFH, NEFL

Products for genes affiliated with Tropical Spastic Paraparesis

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  • Antibodies
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Sources for Tropical Spastic Paraparesis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet