MCID: TRP002
MIFTS: 58

Tropical Spastic Paraparesis

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tropical Spastic Paraparesis

MalaCards integrated aliases for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 12 72 50 14 69
Paraparesis, Tropical Spastic 41
Paraparesis Tropical Spastic 51
Tropical Spastic Paraplegia 12
Htlv-Associated Myelopathy 12
Tropical Spastic Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:321
ICD10 32 G04.1
MeSH 41 D015493
UMLS 69 C0030481

Summaries for Tropical Spastic Paraparesis

NINDS : 50 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to t-cell leukemia and adult t-cell leukemia, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lamivudine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and spinal cord, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia : 72 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 t-cell leukemia 30.8 CNTN2 IL2 IL2RA
2 adult t-cell leukemia 30.8 CNTN2 FOXP3 IL2 IL2RA
3 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.6 FOXP3 IFNG IL10
4 cutaneous t cell lymphoma 30.2 IFNG IL2 IL2RA
5 back pain 30.2 IL6 MMP9
6 folliculitis 30.2 CCL5 IFNG IL2RA
7 b-cell expansion with nfkb and t-cell anergy 30.0 CCL5 IL2 IL2RA
8 human immunodeficiency virus type 1 28.5 CCL5 HLA-B IFNG IL10 IL2 IL6
9 psoriasis 28.5 CCL5 CXCR3 IFNG IL10 IL2 IL2RA
10 multiple sclerosis 28.5 CCL5 CXCR3 FOXP3 IFNG IL10 IL2
11 systemic lupus erythematosus 27.3 CCL5 CXCR3 FOXP3 IFNG IL10 IL2
12 htlv-1 associated myelopathy/tropical spastic paraparesis 12.7
13 myelopathy, htlv-1-associated 12.4
14 human t-cell leukemia virus type 1 11.5
15 retrovirus-associated myelopathy 11.3
16 spastic paraparesis 11.2
17 spasticity 11.2
18 leukemia 10.7
19 variola major 10.5 IFNG IL2
20 microscopic polyangiitis 10.5 HLA-B IL10
21 acute necrotizing encephalitis 10.5 FOXP3 IFNG
22 autoimmune myocarditis 10.5 IFNG IL2
23 berylliosis 10.5 IFNG IL2
24 sporotrichosis 10.4 IFNG IL10
25 dermatitis 10.4
26 lymphoma 10.4
27 baylisascariasis 10.4 IFNG IL10
28 clonorchiasis 10.4 IFNG IL10 IL2
29 chronic active epstein-barr virus infection 10.4 IFNG IL10 IL2
30 eye lymphoma 10.4 IL10 IL6
31 coccidiosis 10.4 IFNG IL10 IL2
32 lepromatous leprosy 10.4 IFNG IL10 IL2
33 herpes zoster 10.4 IFNG IL10 IL2
34 b-cell growth factor 10.4 IFNG IL6
35 leprosy 3 10.4 IFNG IL10 IL2
36 hyperlucent lung 10.4 IFNG IL10 IL2RA
37 chronic graft versus host disease 10.3 IFNG IL10 IL2RA
38 atopic keratoconjunctivitis 10.3 IFNG IL2
39 food allergy 10.3 FOXP3 IFNG IL10
40 schistosomiasis 10.3 IFNG IL10 IL2
41 streptococcal toxic-shock syndrome 10.3 IL2 IL6
42 cutaneous leishmaniasis 10.3 FOXP3 IFNG IL10
43 african tick-bite fever 10.3 CCL5 IFNG
44 autoimmune disease of endocrine system 10.3 FOXP3 IFNG IL2
45 diabetic foot ulcers 10.3 IL6 MMP9
46 myasthenia gravis 10.3 IFNG IL10 IL2
47 extramedullary plasmacytoma 10.3 IL2 IL6
48 pulmonary tuberculosis 10.3 IFNG IL10 IL2
49 multicentric castleman disease 10.3 IFNG IL10 IL6
50 hand, foot and mouth disease 10.3 IFNG IL10 IL6

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to Tropical Spastic Paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

Symptoms:

12
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.8 MMP9 NFKB1 TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 NFKB1 PTPN13 TNFRSF4 MMP9 IL6 IFNL3
2 cellular MP:0005384 10.18 NFKB1 PTPN13 IL6 TNFRSF4 MMP9 IFNG
3 immune system MP:0005387 10.18 NFKB1 PTPN13 TNFRSF4 MMP9 IL2RA IL6
4 growth/size/body region MP:0005378 10.13 MMP9 NFKB1 PTPN13 IL6 TNFRSF4 IL2RA
5 digestive/alimentary MP:0005381 10.11 NFKB1 IL6 TNFRSF4 MMP9 IL2RA IL10
6 integument MP:0010771 9.87 MMP9 NFKB1 IL6 TNFRSF4 IFNG IL10
7 liver/biliary system MP:0005370 9.8 NFKB1 IL6 TNFRSF4 IFNG IL10 FOXP3
8 respiratory system MP:0005388 9.65 NFKB1 TNFRSF4 MMP9 IL2RA IL6 IL10
9 neoplasm MP:0002006 9.63 MMP9 IL6 IFNG CXCR3 IL10 IL2
10 vision/eye MP:0005391 9.23 PTPN13 IL6 MMP9 IFNG IL2RA IL10

Drugs & Therapeutics for Tropical Spastic Paraparesis

Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
7 Anti-Infective Agents Phase 2, Phase 3, Early Phase 1
8 Antimetabolites Phase 2, Phase 3,Early Phase 1
9 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
10 Antiviral Agents Phase 2, Phase 3,Early Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
12 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
13 Antifungal Agents Phase 2, Phase 3
14 Antirheumatic Agents Phase 2, Phase 3
15 Calcineurin Inhibitors Phase 2, Phase 3
16 Cyclosporins Phase 2, Phase 3
17 Dermatologic Agents Phase 2, Phase 3
18 Immunosuppressive Agents Phase 2, Phase 3
19 Anticonvulsants Phase 3
20 Antimanic Agents Phase 3
21 Central Nervous System Depressants Phase 3
22 GABA Agents Phase 3
23 Neurotransmitter Agents Phase 3
24 Psychotropic Drugs Phase 3
25 Tranquilizing Agents Phase 3
26 Antioxidants Phase 3
27 Phosphodiesterase Inhibitors Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29 Protective Agents Phase 3
30 Radiation-Protective Agents Phase 3
31 Vasodilator Agents Phase 3
32
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
33
Infliximab Approved Phase 2 170277-31-3
34 Adjuvants, Immunologic Phase 2
35 Interferon-beta Phase 2
36 interferons Phase 2
37 Gastrointestinal Agents Phase 2
38 Antibodies Phase 1
39 Antibodies, Monoclonal Phase 1
40 Immunoglobulins Phase 1
41 HIV Integrase Inhibitors Early Phase 1
42 Integrase Inhibitors Early Phase 1
43 Raltegravir Potassium Early Phase 1

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
4 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
5 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
9 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
10 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
11 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
12 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819
13 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Unknown status NCT01754311
14 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
15 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
16 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
17 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
18 Dual Algorithm Post Market Clinical Study Completed NCT03146013
19 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Recruiting NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
20 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
21 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir
22 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Valproic Acid

Search NIH Clinical Center for Tropical Spastic Paraparesis

Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

The Foundational Model of Anatomy Ontology organs/tissues related to Tropical Spastic Paraparesis:

18
Spinal Cord

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

38
T Cells, Spinal Cord, Skin, Eye, Lung, Brain, Nk Cells

Publications for Tropical Spastic Paraparesis

Articles related to Tropical Spastic Paraparesis:

(show top 50) (show all 419)
# Title Authors Year
1
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
2
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
3
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
4
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
5
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
6
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-I^, and TNF-I+ in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
7
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
8
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
9
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
10
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
11
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
12
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2017
13
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
14
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
15
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
16
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
17
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
18
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
19
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
20
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
21
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
22
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
23
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
24
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
25
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. ( 25833232 )
2015
26
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. ( 27500208 )
2015
27
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
28
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
29
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2015
30
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
31
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
32
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
33
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
34
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2015
35
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
36
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
37
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
38
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25760424 )
2015
39
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
40
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. ( 25233462 )
2014
41
HTLV-I associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. ( 25196582 )
2014
42
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
43
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
44
Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis. ( 24603733 )
2014
45
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3-Dimensional MR Images. ( 22303896 )
2014
46
Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24815740 )
2014
47
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
48
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
49
Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients. ( 24321043 )
2014
50
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24704970 )
2014

Variations for Tropical Spastic Paraparesis

Expression for Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for Tropical Spastic Paraparesis

Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL5 HLA-B IFNG IFNL3 IL10 IL2
2
Show member pathways
13.8 CCL5 CXCR3 IL10 IL2 IL2RA IL6
3
Show member pathways
13.62 CCL5 CXCR3 IFNG IFNL3 IL10 IL2
4
Show member pathways
13.52 CCL5 IFNG IL10 IL2 IL2RA IL6
5
Show member pathways
13.41 CCL5 CXCR3 IL10 IL2 IL2RA IL6
6
Show member pathways
13.23 CCL5 CXCR3 IL10 IL2 IL2RA IL6
7
Show member pathways
13.17 CCL5 HLA-B IFNG IFNL3 IL10 IL2
8
Show member pathways
12.95 HLA-B IL2 IL2RA IL6 NFKB1
9 12.85 IFNG IL2 IL2RA IL6 MMP9 NFKB1
10
Show member pathways
12.83 FOXP3 HLA-B IFNG IL10 IL2 IL2RA
11
Show member pathways
12.77 CCL5 HLA-B IFNG IL2 IL2RA IL6
12
Show member pathways
12.74 CCL5 IFNG IFNL3 IL6 NFKB1
13
Show member pathways
12.65 IFNG IL10 IL2 IL2RA NFKB1
14
Show member pathways
12.61 IFNG IL10 IL2 IL6 NFKB1
15
Show member pathways
12.55 HLA-B IL6 MMP9 NFKB1
16
Show member pathways
12.54 CCL5 IFNG IL10 IL2 IL6 NFKB1
17
Show member pathways
12.51 FOXP3 IFNG IL10 IL2 IL2RA IL6
18
Show member pathways
12.45 IFNG IL10 IL2 IL6 NFKB1
19 12.44 HLA-B IL2 IL2RA IL6 NFKB1
20 12.37 CCL5 FOXP3 IFNG IL10 IL2 IL2RA
21
Show member pathways
12.35 IFNG IL6 MMP9 NFKB1
22
Show member pathways
12.35 CCL5 IFNG IL2 IL6 NFKB1
23 12.32 HLA-B IFNG IL10 NFKB1
24
Show member pathways
12.31 IFNG IFNL3 IL10 IL2 IL2RA IL6
25 12.25 IFNG IL10 IL6 NFKB1
26 12.21 IFNG IL6 MMP9 NFKB1
27
Show member pathways
12.17 HLA-B IFNG IL10 IL2 IL6
28 12.05 IFNG IL2 IL6 MMP9
29
Show member pathways
12.02 IFNG IL2 IL2RA NFKB1
30
Show member pathways
12.01 IL2 IL2RA NFKB1
31 11.99 CCL5 IL6 MMP9 NFKB1
32 11.99 IFNG IL10 IL2 IL2RA IL6
33 11.97 IL10 IL6 MMP9
34
Show member pathways
11.96 IFNG IL10 IL2 IL6
35
Show member pathways
11.94 IL2 IL2RA NFKB1
36 11.91 IFNG IL10 IL6 NFKB1
37 11.9 IFNG IL6 NFKB1
38
Show member pathways
11.87 FOXP3 IL6 NFKB1
39 11.87 IFNG IL10 IL2 IL2RA IL6
40 11.86 CCL5 IFNG IL6
41 11.84 IFNG IL2 IL6 NFKB1
42 11.83 IFNG IL6 NFKB1
43
Show member pathways
11.79 FOXP3 IFNG IL2 IL2RA
44 11.78 IL10 IL6 NFKB1
45 11.78 IFNG IL10 IL2 IL6
46 11.78 CXCR3 IFNG IL10 IL2 IL2RA
47
Show member pathways
11.73 FOXP3 IL2 IL2RA NFKB1
48 11.71 IFNG IL2 NFKB1
49 11.7 IL6 MMP9 NFKB1
50 11.69 CCL5 IL6 MMP9

GO Terms for Tropical Spastic Paraparesis

Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CCL5 IFNG IFNL3 IL10 IL2 IL6
2 extracellular region GO:0005576 9.56 CCL5 IFNG IFNL3 IL10 IL2 IL6
3 cell surface GO:0009986 9.02 CNTN2 CXCR3 HLA-B IL2RA TNFRSF4

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 IL10 IL2 IL6 MMP9 NFKB1
2 regulation of receptor activity GO:0010469 9.93 CCL5 IFNG IFNL3 IL10 IL2 IL6
3 cellular response to lipopolysaccharide GO:0071222 9.77 IL10 IL6 NFKB1
4 response to virus GO:0009615 9.76 CCL5 FOXP3 IFNG
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 CCL5 IFNG IL2 IL6
6 inflammatory response GO:0006954 9.7 CCL5 CXCR3 IL10 IL2RA IL6 NFKB1
7 negative regulation of T cell proliferation GO:0042130 9.67 FOXP3 IL10 IL2RA
8 positive regulation of T cell proliferation GO:0042102 9.67 CCL5 IL2 IL2RA IL6
9 negative regulation of inflammatory response GO:0050728 9.65 FOXP3 IL10 IL2 IL2RA NFKB1
10 positive regulation of JAK-STAT cascade GO:0046427 9.61 CCL5 IL6
11 positive regulation of T cell differentiation GO:0045582 9.59 IL2 IL2RA
12 negative regulation of immune response GO:0050777 9.58 FOXP3 IL2RA
13 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL2 IL6 TNFRSF4
14 negative regulation of interleukin-17 production GO:0032700 9.57 FOXP3 IFNG
15 positive regulation of regulatory T cell differentiation GO:0045591 9.56 FOXP3 IL2
16 regulation of T cell activation GO:0050863 9.55 CCL5 IFNL3
17 negative regulation of T-helper 17 cell differentiation GO:2000320 9.52 FOXP3 IL2
18 regulation of T cell anergy GO:0002667 9.51 FOXP3 HLA-B
19 negative regulation of lymphocyte proliferation GO:0050672 9.5 FOXP3 IL2 IL2RA
20 regulation of T cell homeostatic proliferation GO:0046013 9.48 IL2 IL2RA
21 regulation of regulatory T cell differentiation GO:0045589 9.26 FOXP3 IFNG IL2 IL2RA
22 immune response GO:0006955 9.23 CCL5 HLA-B IFNG IL10 IL2 IL2RA

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL5 IFNG IFNL3 IL10 IL2 IL6

Sources for Tropical Spastic Paraparesis

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