TSP
MCID: TRP002
MIFTS: 67

Tropical Spastic Paraparesis (TSP) malady

Neuronal diseases, Infectious diseases, Immune diseases categories

Summaries for Tropical Spastic Paraparesis

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8Disease Ontology, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in spinal cord, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. the infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards: Tropical Spastic Paraparesis, also known as human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis, is related to leukemia and t-cell leukemia, and has symptoms including spasms, sensory disturbance and muscle stiffness. An important gene associated with Tropical Spastic Paraparesis is KLRK1 (killer cell lectin-like receptor subfamily K, member 1), and among its related pathways are TGF-beta Signaling Pathways and Apoptosis Pathway. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are skeleton and liver/biliary system.

NINDS:43 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:63 Tropical spastic paraparesis (TSP), also known as HTLV-associated myelopathy or chronic progressive... more...

Description from OMIM:46 159580

Aliases & Classifications for Tropical Spastic Paraparesis

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
tropical spastic paraparesis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

tropical spastic paraparesis 8 43 10 48 46 60
human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis 48
human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis 48
htlv-1-associated myelopathy/tropical spastic paraparesis 48
paraparesis tropical spastic 44
tropical spastic paraplegia 8
htlv-associated myelopathy 8
tropical spastic paralysis 8
ham/tsp 48
tsp 48


External Ids:

Disease Ontology8 DOID:321
OMIM46 159580
MeSH34 D015493
SNOMED-CT56 192733005, 45129002
ICD10 via Orphanet26 G04.1
ICD1025 G04.1

Related Diseases for Tropical Spastic Paraparesis

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17GeneCards, 18GeneDecks
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Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4IL2, KLRK1, JUN, MBP, FASLG, HLA-A
2t-cell leukemia31.4JUN, FASLG, NFKB1, MYC, IL2RA, IL2
3dermatitis31.0CX3CR1
4multiple sclerosis31.0IL2, IL2RA, CX3CR1, KLRK1, CD274, VDR
5neuropathy30.8MBP
6vasculitis30.5NFKB1
7thyroiditis30.3FASLG
8sarcoma30.3IL2, VDR
9acute leukemia30.3IL2
10psoriasis30.3KIR2DS1, IL2, HLA-A, VDR, CX3CR1, IL2RA
11systemic lupus erythematosus30.3KLRK1, RPS27A, PDCD1, FASLG, HLA-A, CX3CR1
12colorectal cancer29.8KLRK1, RPS27A, FASLG, HLA-A, NFKB1, MYC
13adult t-cell leukemia10.7
14htlv-1 associated myelopathy/tropical spastic paraparesis10.6
15neurologic diseases10.5
16htlv-1 associated myelopathy10.5
17retrovirus-associated myelopathy10.5
18cerebritis10.5
19adult lymphoma10.5
20spinal cord disease10.5
21myelitis10.4
22lateral sclerosis10.4
23amyotrophic lateral sclerosis10.4
24peripheral neuropathy10.4
25strongyloidiasis10.2
26folliculitis10.2
27fibrous histiocytoma10.2
28acute t cell leukemia10.2
29postpartum depression10.2
30hemoglobinuria10.2
31neuroaxonal dystrophy10.2
32central nervous system leukemia10.2
33protein s deficiency10.2
34lyme disease10.2
35cerebral lymphoma10.2
36spinal cord sarcoma10.2
37osteoporosis10.2
38central nervous system disease10.2
39cutaneous t cell lymphoma10.2
40histiocytoma10.2
41hypertension10.2
42lupus erythematosus10.2
43nervous system disease10.2
44paraplegia10.2
45syphilis10.2
46t cell deficiency10.2
47acute ackee fruit intoxication10.2
48pseudopseudohypoparathyroidism10.2
49ankylosing spondylitis10.0HLA-A
50neuroblastoma10.0MYC

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Clinical Features for Tropical Spastic Paraparesis

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46OMIM, 8Disease Ontology
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Clinical features from OMIM:

159580

Clinical synopsis from OMIM:

159580

Symptoms:

8
  • spasms
  • sensory disturbance
  • muscle stiffness
  • spastic weakness of both legs

Drugs & Therapeutics for Tropical Spastic Paraparesis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tropical Spastic Paraparesis

Drug clinical trials:

Search ClinicalTrials for Tropical Spastic Paraparesis

Search NIH Clinical Center for Tropical Spastic Paraparesis

Search CenterWatch for Tropical Spastic Paraparesis

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

32
T cells, Spinal cord, Breast, Nk cells, Testes, Brain, Thyroid, Skeletal muscle, B cells, Thymus

FMA organs/tissues related to Tropical Spastic Paraparesis:

14
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.2MYC, FASLG, PDCD1
2MP:000537010.2IL2, MYC, NFKB1, FASLG, PDCD1, JUN
3MP:000538110.1FASLG, NFKB1, MYC, VDR, CX3CR1, IL2RA
4MP:000539710.0IL2, KLRK1, JUN, PDCD1, MBP, FASLG
5MP:000538710.0FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1
6MP:00053849.9FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1
7MP:00107719.9JUN, FASLG, MYC, VDR, CX3CR1
8MP:00107689.9FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1

Publications for Tropical Spastic Paraparesis

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50PubMed
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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23022356)
2013
2
Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4(+) T Cells in Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients. (24041428)
2013
3
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
4
Monitoring the HTLV-1 proviral load in the peripheral blood of asymptomatic carriers and patients with HTLV-associated myelopathy/tropical spastic paraparesis from a Brazilian cohort: ROC curve analysis to establish the threshold for risk disease. (22337307)
2012
5
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
6
Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders. (21851845)
2011
7
Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients. (19838519)
2009
8
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. (18691139)
2008
9
Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (18937847)
2008
10
Blockade of IL-2 receptor suppresses HTLV-I and IFN-gamma expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (17409595)
2007
11
HTLV-I and neurological disease: from tropical spastic paraparesis to HTLV-I-associated myelopathy: what next? (18090720)
2007
12
Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. (18078583)
2007
13
Clinical and epidemiological aspects of HTLV-II infection in SALo Paulo, Brazil: presence of tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM) simile diagnosis in HIV-1-co-infected subjects. (17119676)
2006
14
Quantitative assessment of spasticity in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (15804962)
2005
15
HTLV-I associated myelopathy/tropical spastic paraparesis in a 7-year-old boy associated with infective dermatitis. (15240193)
2004
16
Extracellular matrix protein expression in cerebrospinal fluid from patients with tropical spastic paraparesis associated with HTLV-I and Creutzfeldt-Jakob disease. (15115246)
2004
17
Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (12587066)
2003
18
HTLV-I associated myelopathy/tropical spastic paraparesis with pseudohypothyroidism. (11591873)
2001
19
Serum S100B levels in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (10822451)
2000
20
Clinical evolution of tropical spastic paraparesis: The Tumaco experience. (16873192)
1999
21
Long-term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: a combined clinical, virological and immunological study. (9106118)
1997
22
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
23
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
24
Study of lower limb somatosensory evoked potentials in 96 cases of HTLV-I-associated myelopathy/tropical spastic paraparesis. (8791242)
1996
25
Tropical spastic paraparesis and HTLV-I infection: clinical and epidemiological study in Lima, Peru. (8981307)
1996
26
Antibody-dependent cell-mediated cytotoxicity (ADCC) in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) (8902722)
1996
27
HTLV-I provirus in seronegative Chilean patients with tropical spastic paraparesis. (8888190)
1996
28
Cutaneous T-cell lymphoma, tropical spastic paraparesis, cerebral vasculitis, and protein S deficiency in a patient with HTLV-I. (8865796)
1996
29
Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. (7703492)
1995
30
Contralateral early blink reflex in patients with HTLV-I associated myelopathy/tropical spastic paraparesis. (7722534)
1995
31
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. (8555734)
1995
32
In vivo proviral burden and viral RNA expression in T cell subsets of patients with human T lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis. (7485696)
1995
33
Skeletal muscle involvement in tropical spastic paraparesis/HTLV-1-associated myelopathy. (8041400)
1994
34
Serological tests for Lyme disease in patients with tropical spastic paraparesis and healthy Jamaicans. (7855925)
1994
35
Isolation of HTLV-II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV-I-associated myelopathy/tropical spastic paraparesis. (8489210)
1993
36
FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. (7683633)
1993
37
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
38
Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation. (1457215)
1992
39
Absence of Epstein-Barr virus activation in HTLV-I-associated tropical spastic paraparesis. (1648684)
1991
40
Tropical spastic paraparesis and HTLV-I myelopathy: clinical features and pathogenesis. (2183307)
1990
41
A cluster of HTLV-1 associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution. (2303831)
1990
42
Borrelia burgdorferi and tropical spastic paraparesis. (1978014)
1990
43
MRI of thoracic cord in tropical spastic paraparesis. (2292711)
1990
44
HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis. (2369441)
1990
45
Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis. (2200942)
1990
46
Tropical spastic paraparesis: a model of virus-induced, cytotoxic T-cell-mediated demyelination? (2817828)
1989
47
Magnetic resonance imaging in an HTLV-I antibody positive patient with tropical spastic paraparesis. (2904977)
1988
48
Tropical spastic paraparesis in the Seychelles Islands: a clinical and case-control neuroepidemiologic study. (3614652)
1987
49
Tropical spastic paraparesis: HTLV-I antibodies in patients from the Seychelles. (2878366)
1987
50
HTLV-I and HTLV-III antibodies and tropical spastic paraparesis. (2866324)
1985

Genetic Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

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Sources:
52R&D Systems, 59Tocris Bioscience, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 49PharmGKB, 29KEGG
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Pathways related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYC
2
Hide members
10.4JUN, IL2RA
3
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10.3IL2, IL2RA, FASLG
4
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10.3MYC, FASLG, NFKB1
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3FASLG, VDR, JUN
610.3MYC, IL2RA, NFKB1
710.3JUN, VDR, MYC
8
Hide members
10.3NFKB1, RPS27A, JUN
910.3IL2RA, JUN, IL2
10
Hide members
10.3NFKB1, JUN, MYC
11
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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10.3MYC, JUN, NFKB1
1210.3NFKB1, MYC, JUN
1310.3NFKB1, JUN, IL2
1410.3JUN, IL2, NFKB1
15
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.3NFKB1, IL2, JUN
1610.3JUN, NFKB1, IL2
1710.3JUN, IL2, NFKB1
18
Hide members
10.3KLRK1, HLA-A, RPS27A, NFKB1
19
Hide members
10.3FASLG, IL2RA, IL2, JUN
20
Hide members
10.3KIR2DS2, KIR2DS1, KIR2DL4
2110.3JUN, FASLG, MYC, NFKB1
22
Hide members
10.3JUN, FASLG, NFKB1, MYC
23
Hide members
10.3MYC, JUN, FASLG, NFKB1
24
Hide members
10.3MYC, NFKB1, JUN, FASLG
25
Hide members
10.3MYC, NFKB1, FASLG, JUN
2610.3HLA-A, NFKB1, MYC, JUN
27
Hide members
10.3RPS27A, IL2, IL2RA, NFKB1
28
Hide members
10.3NFKB1, JUN, IL2, PDCD1
2910.3JUN, IL2RA, MYC, IL2
30
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10.3IL2RA, JUN, MYC, IL2
31
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10.3JUN, NFKB1, IL2RA, IL2
32
Hide members
10.3NFKB1, IL2, IL2RA, JUN
3310.2IL2, JUN, NFKB1, MYC
34
Hide members
10.2FASLG, IL2RA, CX3CR1, MYC, NFKB1
3510.2HLA-A, IL2, JUN, IL2RA, FASLG
36
Hide members
10.2IL2RA, HLA-A, RPS27A, IL2, NFKB1
37
Hide members
10.2MYC, IL2, NFKB1, FASLG, IL2RA
3810.2IL2, NFKB1, MYC, IL2RA, FASLG
39
Hide members
10.2FASLG, NFKB1, MYC, JUN, IL2
40
Immune response IL-2 activation and signaling pathway
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10.2NFKB1, JUN, IL2, IL2RA, MYC
41
Hide members
10.2MYC, IL2RA, IL2, NFKB1, JUN
42
Hide members
10.2JUN, NFKB1, MYC, IL2RA, IL2
43
Hide members
10.2KIR2DL4, KIR2DS1, KIR2DS5, KIR2DS2
44
Hide members
10.2JUN, HLA-A, FASLG, IL2, IL2RA, NFKB1
45
Hide members
10.2NFKB1, HLA-A, FASLG, JUN, IL2, IL2RA
4610.2NFKB1, HLA-A, IL2, MYC, JUN, IL2RA
47
Hide members
10.1NFKB1, KLRK1, KIR2DS2, KIR2DS1, KIR2DS5, RPS27A
48
Hide members
10.0CD274, IL2, PDCD1, JUN, RPS27A, KLRK1
49
Hide members
10.0KIR2DL5A, KIR2DL4, KIR2DS1, KIR2DS5, KIR2DS2, KIR2DS3
50
Hide members
9.7KIR2DS3, KLRK1, JUN, HLA-A, NFKB1, IL2

Compounds for genes affiliated with Tropical Spastic Paraparesis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9FASLG
2pge24410.8IL2
3indomethacin44 59 28 1113.8RPS27A, MBP
4c-d4t4410.7FASLG, IL2RA, IL2
5arsenite44 2411.7FASLG, RPS27A, VDR
6butyrate4410.7RPS27A
7dexamethasone44 49 28 1113.7MYC, FASLG, JUN, VDR
8sodium arsenite4410.7FASLG, MYC, JUN, IL2RA
9estrogen4410.7VDR
10propanil4410.7RPS27A, MYC, IL2
11lactacystin4410.7JUN, FASLG, MYC, VDR, RPS27A
124-hydroxytamoxifen4410.7MYC, FASLG, JUN, VDR
13bortezomib44 1111.7MYC, FASLG, JUN, RPS27A
14levamisole44 1111.6IL2, HLA-A, IL2RA
15mg 13244 5911.6MYC, JUN, VDR, RPS27A, FASLG
16tamoxifen44 49 28 1113.6RPS27A, JUN, FASLG, IL2, VDR
17thalidomide44 49 59 1113.6IL2, NFKB1, FASLG, IL2RA
18anisomycin44 1111.6FASLG, JUN, MYC, IL2RA
19herbimycin a44 5911.6RPS27A, JUN, MYC, IL2RA, IL2
20rantes4410.6IL2RA, IL2, FASLG, JUN
21ionomycin4410.6JUN, FASLG, CD274, IL2, IL2RA
22calcitriol44 59 11 2413.6MYC, JUN, VDR, IL2RA, IL2
235fluorouracil4410.6FASLG, HLA-A, VDR, IL2RA, IL2
24n acetylcysteine4410.6MYC, RPS27A, JUN, FASLG, MBP, IL2RA
25prednisolone44 28 1112.6MBP, MYC, IL2RA
26rapamycin4410.6JUN, RPS27A, IL2, IL2RA, MYC, FASLG
27tacrolimus44 49 1112.6VDR, IL2, IL2RA, FASLG, HLA-A, MYC
28actinomycin d4410.6IL2, VDR, MYC, FASLG, JUN, RPS27A
29genistein44 28 59 2 11 2415.6MYC, FASLG, VDR, IL2RA, IL2, JUN
302-chlorodeoxyadenosine4410.5IL2RA, FASLG, IL2
31cytarabine44 49 1112.5MBP, FASLG, MYC, JUN
32etoposide44 49 59 1113.5JUN, FASLG, NFKB1, MYC, IL2RA
33thymidine44 2411.5MYC, IL2RA, VDR, FASLG, MBP, IL2
34camptothecin44 59 1112.5JUN, MYC, FASLG, RPS27A
35cisplatin44 49 59 1113.5IL2RA, IL2, MYC, FASLG, RPS27A, MBP
36vegf4410.5RPS27A, IL2RA, IL2, CX3CR1, MYC, FASLG
37adenylate4410.5FASLG, IL2RA, VDR, HLA-A, RPS27A, MBP
38imatinib44 49 1112.5FASLG, RPS27A, MYC, KLRK1
392,5-oligoadenylate4410.5MYC, IL2RA, IL2
40cyclophosphamide44 49 1112.5IL2RA, FASLG, MBP, IL2
41cyclosporin a44 28 5912.4RPS27A, IL2, MBP, FASLG, HLA-A, MYC
42arginine4410.4IL2RA, VDR, HLA-A, RPS27A, KIR2DL4, KLRK1
43tyrosine4410.3FASLG, RPS27A, JUN, HLA-A, KIR2DL5A, IL2
445-aza-2deoxycytidine4410.3HLA-A, RPS27A, MYC, FASLG
45retinoic acid44 2411.3KLRK1, FASLG, MBP, JUN, MYC, VDR
46paraffin4410.3FASLG, RPS27A, MBP, IL2RA, MYC
47protamine4410.3MBP, RPS27A, IL2
48n-(4-hydroxyphenyl)retinamide4410.2RPS27A, JUN, MYC
49phosphatidylinositol4410.2JUN, IL2RA, CX3CR1, MYC, KLRK1, FASLG
50il 104410.0IL2RA, VDR, IL2

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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16Gene Ontology
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Cellular components related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3IL2RA, CD274, FASLG, PDCD1
2plasma membraneGO:0058869.4KIR2DS5, RPS27A, PDCD1, MBP, HLA-A, CD274

Biological processes related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.7IL2, IL2RA
2negative regulation of inflammatory responseGO:05072810.6NFKB1, IL2RA, IL2
3cellular defense responseGO:00696810.6KIR2DL4, KIR2DS3, CX3CR1
4toll-like receptor 10 signaling pathwayGO:03416610.6RPS27A, JUN, NFKB1
5toll-like receptor 5 signaling pathwayGO:03414610.6RPS27A, JUN, NFKB1
6regulation of immune responseGO:05077610.6HLA-A, KIR2DS2, KIR2DL4, KIR2DS1
7toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.6NFKB1, JUN, RPS27A
8toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.5NFKB1, JUN, RPS27A
9toll-like receptor 9 signaling pathwayGO:03416210.5RPS27A, JUN, NFKB1
10toll-like receptor 2 signaling pathwayGO:03413410.5NFKB1, JUN, RPS27A
11negative regulation of apoptotic processGO:04306610.5RPS27A, NFKB1, MYC, CX3CR1, IL2
12TRIF-dependent toll-like receptor signaling pathwayGO:03566610.5NFKB1, JUN, RPS27A
13positive regulation of transcription from RNA polymerase II promoterGO:04594410.5RPS27A, JUN, NFKB1, MYC, VDR, IL2
14MyD88-independent toll-like receptor signaling pathwayGO:00275610.4RPS27A, JUN, NFKB1
15innate immune responseGO:04508710.4RPS27A, JUN, NFKB1, KIR2DS2, KIR2DS1, KIR2DS5
16MyD88-dependent toll-like receptor signaling pathwayGO:00275510.4NFKB1, JUN, RPS27A
17toll-like receptor 3 signaling pathwayGO:03413810.3NFKB1, JUN, RPS27A
18toll-like receptor 4 signaling pathwayGO:03414210.3NFKB1, JUN, RPS27A
19immune responseGO:00695510.3KIR2DS5, MBP, FASLG, HLA-A, CD274, IL2RA
20negative regulation of transcription from RNA polymerase II promoterGO:00012210.1RPS27A, FASLG, NFKB1, MYC, VDR
21response to growth factor stimulusGO:07084810.1MYC, FASLG

Products for genes affiliated with Tropical Spastic Paraparesis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Tropical Spastic Paraparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet