TSP
MCID: TRP002
MIFTS: 67

Tropical Spastic Paraparesis (TSP) malady

Neuronal diseases, Infectious diseases, Immune diseases categories

Summaries for Tropical Spastic Paraparesis

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8Disease Ontology, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in spinal cord, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. the infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards: Tropical Spastic Paraparesis, also known as human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis, is related to leukemia and t-cell leukemia, and has symptoms including muscle stiffness, sensory disturbance and spasms. An important gene associated with Tropical Spastic Paraparesis is KLRK1 (killer cell lectin-like receptor subfamily K, member 1), and among its related pathways are TGF-beta Signaling Pathways and Apoptosis Pathway. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are skeleton and liver/biliary system.

NINDS:43 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:63 Tropical spastic paraparesis (TSP), also known as HTLV-associated myelopathy or chronic progressive... more...

Description from OMIM:46 159580

Aliases & Classifications for Tropical Spastic Paraparesis

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8Disease Ontology, 43NINDS, 10DISEASES, 48Orphanet, 46OMIM, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
tropical spastic paraparesis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

tropical spastic paraparesis 8 43 10 48 46 60
human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis 48
human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis 48
htlv-1-associated myelopathy/tropical spastic paraparesis 48
paraparesis tropical spastic 44
tropical spastic paraplegia 8
htlv-associated myelopathy 8
tropical spastic paralysis 8
ham/tsp 48
tsp 48


External Ids:

Disease Ontology8 DOID:321
OMIM46 159580
MeSH34 D015493
SNOMED-CT56 192733005, 45129002
ICD10 via Orphanet26 G04.1
ICD1025 G04.1

Related Diseases for Tropical Spastic Paraparesis

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17GeneCards, 18GeneDecks
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Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4IL2, KLRK1, JUN, MBP, FASLG, HLA-A
2t-cell leukemia31.4JUN, FASLG, NFKB1, MYC, IL2RA, IL2
3dermatitis31.0CX3CR1
4multiple sclerosis31.0IL2, IL2RA, CX3CR1, KLRK1, CD274, VDR
5neuropathy30.8MBP
6vasculitis30.5NFKB1
7thyroiditis30.3FASLG
8sarcoma30.3IL2, VDR
9acute leukemia30.3IL2
10psoriasis30.3KIR2DS1, IL2, HLA-A, VDR, CX3CR1, IL2RA
11systemic lupus erythematosus30.3KLRK1, RPS27A, PDCD1, FASLG, HLA-A, CX3CR1
12colorectal cancer29.8KLRK1, RPS27A, FASLG, HLA-A, NFKB1, MYC
13adult t-cell leukemia10.7
14htlv-1 associated myelopathy/tropical spastic paraparesis10.6
15neurologic diseases10.5
16htlv-1 associated myelopathy10.5
17retrovirus-associated myelopathy10.5
18cerebritis10.5
19adult lymphoma10.5
20spinal cord disease10.5
21myelitis10.4
22lateral sclerosis10.4
23amyotrophic lateral sclerosis10.4
24peripheral neuropathy10.4
25strongyloidiasis10.2
26folliculitis10.2
27fibrous histiocytoma10.2
28acute t cell leukemia10.2
29postpartum depression10.2
30hemoglobinuria10.2
31neuroaxonal dystrophy10.2
32central nervous system leukemia10.2
33protein s deficiency10.2
34lyme disease10.2
35cerebral lymphoma10.2
36spinal cord sarcoma10.2
37osteoporosis10.2
38central nervous system disease10.2
39cutaneous t cell lymphoma10.2
40histiocytoma10.2
41hypertension10.2
42lupus erythematosus10.2
43nervous system disease10.2
44paraplegia10.2
45syphilis10.2
46t cell deficiency10.2
47acute ackee fruit intoxication10.2
48pseudopseudohypoparathyroidism10.2
49ankylosing spondylitis10.0HLA-A
50neuroblastoma10.0MYC

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Clinical Features for Tropical Spastic Paraparesis

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46OMIM, 8Disease Ontology
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Clinical features from OMIM:

159580

Clinical synopsis from OMIM:

159580

Symptoms:

8
  • muscle stiffness
  • sensory disturbance
  • spasms
  • spastic weakness of both legs

Drugs & Therapeutics for Tropical Spastic Paraparesis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Tropical Spastic Paraparesis

Drug clinical trials:

Search ClinicalTrials for Tropical Spastic Paraparesis

Search NIH Clinical Center for Tropical Spastic Paraparesis

Search CenterWatch for Tropical Spastic Paraparesis

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

32
T cells, Spinal cord, Breast, Nk cells, Brain, Testes, Thyroid, B cells, Thymus, Skeletal muscle

FMA organs/tissues related to Tropical Spastic Paraparesis:

14
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.2MYC, FASLG, PDCD1
2MP:000537010.2IL2, MYC, NFKB1, FASLG, PDCD1, JUN
3MP:000538110.1FASLG, NFKB1, MYC, VDR, CX3CR1, IL2RA
4MP:000539710.0IL2, KLRK1, JUN, PDCD1, MBP, FASLG
5MP:000538710.0FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1
6MP:00053849.9FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1
7MP:00107719.9JUN, FASLG, MYC, VDR, CX3CR1
8MP:00107689.9FASLG, MBP, PDCD1, JUN, KLRK1, NFKB1

Publications for Tropical Spastic Paraparesis

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50PubMed
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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
2
Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms. (22460962)
2012
3
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. (22405461)
2012
4
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
5
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. (19578703)
2009
6
Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. (19040291)
2008
7
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. (18691139)
2008
8
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. (18664281)
2008
9
Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy. (18657726)
2008
10
High production of RANTES and MIP-1alpha in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). (17588676)
2007
11
Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease. (16545011)
2006
12
Human T-cell lymphotropic virus type I (HTLV-I) confirmed by PCR-Southern blot and sequencing analysis in a woman with tropical spastic paraparesis. (16998729)
2006
13
ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals. (15850579)
2005
14
Longer dinucleotide repeat polymorphism in matrix metalloproteinase-9 (MMP-9) gene promoter which correlates with higher HTLV-I Tax mediated transcriptional activity influences the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). (15465610)
2004
15
Polymorphism in the interleukin-10 promoter affects both provirus load and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (15346339)
2004
16
Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers. (12560226)
2003
17
Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. (11120926)
2001
18
Histopathological analysis of four autopsy cases of HTLV-I-associated myelopathy/tropical spastic paraparesis: inflammatory changes occur simultaneously in the entire central nervous system. (10965793)
2000
19
HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) with amyotrophic lateral sclerosis-like manifestations. (11175327)
2000
20
Increased activity of metalloproteinases and their inhibitors in cerebrospinal fluid of patients with tropical spastic paraparesis]. (11016056)
2000
21
Syringohydromyelia or HTLV-I-associated myelopathy/tropical spastic paraparesis. A diagnostic challenge. Case report. (10412531)
1999
22
Detection of human T-lymphotropic virus type I p40tax protein in cerebrospinal fluid cells from patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (10414514)
1999
23
Ultrastructural pathology of a Chilean case of tropical spastic paraparesis/human T-cell lymphotropic type I-associated myelopathy (TSP/HAM). (10445282)
1999
24
Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis). (9184632)
1997
25
Cellular and humoral immune responses associated with HTLV-I associated myelopathy/tropical spastic paraparesis. (9616769)
1997
26
Study of lower limb somatosensory evoked potentials in 96 cases of HTLV-I-associated myelopathy/tropical spastic paraparesis. (8791242)
1996
27
HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis. (8741915)
1996
28
Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis. (8912211)
1996
29
Human T-lymphotropic virus type I (HTLV-I)-specific antibodies and cell-free RNA in crevicular fluid-rich saliva from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy. (8833267)
1995
30
HTLV-negative and HTLV type I-positive tropical spastic paraparesis in northeastern Brazil. (7742045)
1995
31
Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia. (8774979)
1995
32
Elevated levels of iC3b and C4d, but not Bb, complement fragments from plasma of persons infected with human T cell leukemia virus (HTLV) with HTLV-I-associated myelopathy/tropical spastic paraparesis. (7561187)
1995
33
A search for human T-cell leukemia virus type I in the lesions of patients with tropical spastic paraparesis and polymyositis. (7668833)
1995
34
Adult T cell leukemia following HTLV-I-associated myelopathy/tropical spastic paraparesis: case reports and implication to the natural course of ATL. (7564523)
1995
35
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
36
Unintegrated HTLV-I proviral DNA in cell lines and uncultured peripheral blood mononuclear cells from tropical spastic paraparesis (TSP/HAM) and adult T-cell leukemia (ATL) patients. (7994613)
1994
37
Lack of evidence for HTLV-II infection in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in an endemic area. (8318265)
1993
38
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
39
HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States. (1891080)
1991
40
Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis. (2106960)
1990
41
Immunological studies in tropical spastic paraparesis. (2317010)
1990
42
HTLV-1 and tropical spastic paraparesis. 2. The human T-cell lymphotropic virus type 1. (2617642)
1989
43
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
44
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988
45
Intrathecal synthesis of antibodies to human T lymphotropic virus type I and the presence of IgG oligoclonal bands in the cerebrospinal fluid of patients with endemic tropical spastic paraparesis. (2897399)
1988
46
The neuroepidemiology of tropical spastic paraparesis. (2894800)
1988
47
A case of tropical spastic paraparesis in the United Kingdom. (2835412)
1988
48
Bronchoalveolar lymphocytosis in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type 1 (HTLV-1). Clinical, immunologic, and cytologic studies. (2901817)
1988
49
Multiple sclerosis (not tropical spastic paraparesis) on Key West, Florida. (2883504)
1987
50
HTLV-I, visna, and tropical spastic paraparesis. (2873478)
1986

Genetic Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

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52R&D Systems, 59Tocris Bioscience, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 49PharmGKB, 29KEGG
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Pathways related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYC
2
Hide members
10.4IL2RA, JUN
3
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10.3IL2, IL2RA, FASLG
4
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10.3MYC, NFKB1, FASLG
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.3JUN, FASLG, VDR
610.3IL2RA, MYC, NFKB1
710.3VDR, MYC, JUN
8
Hide members
10.3RPS27A, JUN, NFKB1
910.3JUN, IL2RA, IL2
1010.3JUN, NFKB1, MYC
11
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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10.3JUN, NFKB1, MYC
12
Hide members
10.3JUN, NFKB1, MYC
1310.3JUN, NFKB1, IL2
1410.3IL2, NFKB1, JUN
1510.3IL2, NFKB1, JUN
16
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.3IL2, NFKB1, JUN
1710.3JUN, NFKB1, IL2
18
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10.3KLRK1, RPS27A, HLA-A, NFKB1
19
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10.3IL2, IL2RA, FASLG, JUN
20
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10.3KIR2DS2, KIR2DL4, KIR2DS1
2110.3JUN, FASLG, NFKB1, MYC
22
Hide members
10.3JUN, FASLG, NFKB1, MYC
23
Hide members
10.3JUN, FASLG, NFKB1, MYC
24
Hide members
10.3JUN, FASLG, NFKB1, MYC
25
Hide members
10.3MYC, NFKB1, FASLG, JUN
2610.3MYC, NFKB1, HLA-A, JUN
27
Hide members
10.3RPS27A, NFKB1, IL2RA, IL2
28
Hide members
10.3JUN, PDCD1, NFKB1, IL2
2910.3JUN, MYC, IL2RA, IL2
30
Hide members
10.3IL2, IL2RA, MYC, JUN
31
Hide members
10.3JUN, NFKB1, IL2RA, IL2
32
Hide members
10.3IL2, IL2RA, NFKB1, JUN
3310.2JUN, NFKB1, MYC, IL2
34
Hide members
10.2FASLG, NFKB1, MYC, CX3CR1, IL2RA
3510.2IL2, IL2RA, HLA-A, FASLG, JUN
36
Hide members
10.2RPS27A, HLA-A, NFKB1, IL2RA, IL2
37
Hide members
10.2FASLG, NFKB1, MYC, IL2RA, IL2
3810.2FASLG, NFKB1, MYC, IL2RA, IL2
39
Hide members
10.2JUN, FASLG, NFKB1, MYC, IL2
40
Hide members
10.2JUN, NFKB1, MYC, IL2RA, IL2
41
Hide members
10.2JUN, NFKB1, MYC, IL2RA, IL2
42
Immune response IL-2 activation and signaling pathway
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10.2JUN, NFKB1, MYC, IL2RA, IL2
43
Hide members
10.2KIR2DS2, KIR2DL4, KIR2DS1, KIR2DS5
44
Hide members
10.2JUN, FASLG, HLA-A, NFKB1, IL2RA, IL2
45
Hide members
10.2JUN, FASLG, HLA-A, NFKB1, IL2RA, IL2
4610.2JUN, HLA-A, NFKB1, MYC, IL2RA, IL2
47
Hide members
10.1KLRK1, RPS27A, NFKB1, KIR2DS2, KIR2DS1, KIR2DS5
48
Hide members
10.0KLRK1, RPS27A, JUN, PDCD1, HLA-A, NFKB1
49
Hide members
10.0IL2, KIR2DL5A, KIR2DS3, KIR2DS2, KIR2DL4, KIR2DS1
50
Hide members
9.7KIR2DS5, KLRK1, JUN, FASLG, HLA-A, NFKB1

Compounds for genes affiliated with Tropical Spastic Paraparesis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9FASLG
2pge24410.8IL2
3indomethacin44 59 28 1113.8MBP, RPS27A
4c-d4t4410.7FASLG, IL2RA, IL2
5arsenite44 2411.7VDR, FASLG, RPS27A
6butyrate4410.7RPS27A
7dexamethasone44 49 28 1113.7VDR, MYC, FASLG, JUN
8sodium arsenite4410.7JUN, FASLG, MYC, IL2RA
9estrogen4410.7VDR
10propanil4410.7IL2, MYC, RPS27A
11lactacystin4410.7RPS27A, JUN, FASLG, MYC, VDR
124-hydroxytamoxifen4410.7JUN, FASLG, MYC, VDR
13bortezomib44 1111.7MYC, FASLG, JUN, RPS27A
14levamisole44 1111.6HLA-A, IL2RA, IL2
15mg 13244 5911.6RPS27A, JUN, FASLG, MYC, VDR
16tamoxifen44 49 28 1113.6RPS27A, JUN, FASLG, VDR, IL2
17thalidomide44 49 59 1113.6IL2, IL2RA, NFKB1, FASLG
18anisomycin44 1111.6JUN, FASLG, MYC, IL2RA
19herbimycin a44 5911.6RPS27A, JUN, MYC, IL2RA, IL2
20rantes4410.6JUN, FASLG, IL2RA, IL2
21ionomycin4410.6JUN, FASLG, CD274, IL2RA, IL2
22calcitriol44 59 11 2413.6JUN, MYC, VDR, IL2RA, IL2
235fluorouracil4410.6FASLG, HLA-A, VDR, IL2RA, IL2
24n acetylcysteine4410.6RPS27A, JUN, MBP, FASLG, MYC, IL2RA
25prednisolone44 28 1112.6IL2RA, MYC, MBP
26rapamycin4410.6RPS27A, JUN, FASLG, MYC, IL2RA, IL2
27tacrolimus44 49 1112.6RPS27A, FASLG, HLA-A, MYC, VDR, IL2RA
28actinomycin d4410.6RPS27A, JUN, FASLG, MYC, VDR, IL2
29genistein44 28 59 2 11 2415.6JUN, FASLG, MYC, VDR, IL2RA, IL2
302-chlorodeoxyadenosine4410.5IL2, IL2RA, FASLG
31cytarabine44 49 1112.5JUN, MBP, FASLG, MYC
32etoposide44 49 59 1113.5IL2RA, MYC, NFKB1, FASLG, JUN
33thymidine44 2411.5JUN, MBP, FASLG, MYC, VDR, IL2RA
34camptothecin44 59 1112.5RPS27A, JUN, FASLG, MYC
35cisplatin44 49 59 1113.5RPS27A, MBP, FASLG, MYC, IL2RA, IL2
36vegf4410.5RPS27A, JUN, FASLG, MYC, CX3CR1, IL2RA
37adenylate4410.5RPS27A, MBP, FASLG, HLA-A, VDR, IL2RA
38imatinib44 49 1112.5KLRK1, RPS27A, FASLG, MYC
392,5-oligoadenylate4410.5IL2, IL2RA, MYC
40cyclophosphamide44 49 1112.5MBP, FASLG, IL2RA, IL2
41cyclosporin a44 28 5912.4IL2, RPS27A, JUN, MBP, FASLG, HLA-A
42arginine4410.4KLRK1, RPS27A, MBP, HLA-A, VDR, IL2RA
43tyrosine4410.3RPS27A, JUN, PDCD1, MBP, FASLG, HLA-A
445-aza-2deoxycytidine4410.3MYC, HLA-A, FASLG, RPS27A
45retinoic acid44 2411.3KLRK1, RPS27A, JUN, MBP, FASLG, MYC
46paraffin4410.3RPS27A, MBP, FASLG, MYC, IL2RA
47protamine4410.3RPS27A, MBP, IL2
48n-(4-hydroxyphenyl)retinamide4410.2MYC, JUN, RPS27A
49phosphatidylinositol4410.2IL2RA, CX3CR1, MYC, FASLG, JUN, KLRK1
50il 104410.0VDR, IL2RA, IL2

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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16Gene Ontology
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Cellular components related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3IL2RA, CD274, FASLG, PDCD1
2plasma membraneGO:0058869.4KIR2DS5, RPS27A, PDCD1, MBP, HLA-A, CD274

Biological processes related to Tropical Spastic Paraparesis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.7IL2, IL2RA
2negative regulation of inflammatory responseGO:05072810.6NFKB1, IL2RA, IL2
3cellular defense responseGO:00696810.6KIR2DL4, KIR2DS3, CX3CR1
4toll-like receptor 10 signaling pathwayGO:03416610.6RPS27A, JUN, NFKB1
5toll-like receptor 5 signaling pathwayGO:03414610.6RPS27A, JUN, NFKB1
6regulation of immune responseGO:05077610.6HLA-A, KIR2DS2, KIR2DL4, KIR2DS1
7toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.6NFKB1, JUN, RPS27A
8toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.5NFKB1, JUN, RPS27A
9toll-like receptor 9 signaling pathwayGO:03416210.5RPS27A, JUN, NFKB1
10toll-like receptor 2 signaling pathwayGO:03413410.5NFKB1, JUN, RPS27A
11negative regulation of apoptotic processGO:04306610.5RPS27A, NFKB1, MYC, CX3CR1, IL2
12TRIF-dependent toll-like receptor signaling pathwayGO:03566610.5NFKB1, JUN, RPS27A
13positive regulation of transcription from RNA polymerase II promoterGO:04594410.5RPS27A, JUN, NFKB1, MYC, VDR, IL2
14MyD88-independent toll-like receptor signaling pathwayGO:00275610.4RPS27A, JUN, NFKB1
15innate immune responseGO:04508710.4RPS27A, JUN, NFKB1, KIR2DS2, KIR2DS1, KIR2DS5
16MyD88-dependent toll-like receptor signaling pathwayGO:00275510.4NFKB1, JUN, RPS27A
17toll-like receptor 3 signaling pathwayGO:03413810.3NFKB1, JUN, RPS27A
18toll-like receptor 4 signaling pathwayGO:03414210.3NFKB1, JUN, RPS27A
19immune responseGO:00695510.3KIR2DS5, MBP, FASLG, HLA-A, CD274, IL2RA
20negative regulation of transcription from RNA polymerase II promoterGO:00012210.1RPS27A, FASLG, NFKB1, MYC, VDR
21response to growth factor stimulusGO:07084810.1MYC, FASLG

Products for genes affiliated with Tropical Spastic Paraparesis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tropical Spastic Paraparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet