TSP
MCID: TRP002
MIFTS: 44

Tropical Spastic Paraparesis (TSP) malady

Neuronal, Infectious, Immune categories

Summaries for Tropical Spastic Paraparesis

Sources:
8Disease Ontology, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in spinal cord, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. the infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

MalaCards: Tropical Spastic Paraparesis, also known as human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis, is related to adult t-cell leukemia and htlv-1 associated myelopathy/tropical spastic paraparesis, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is KLRK1 (killer cell lectin-like receptor subfamily K, member 1). Affiliated tissues include spinal cord, spinal cord and thymus.

NINDS:44 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes

Wikipedia:64 Tropical spastic paraparesis (TSP), also known as HTLV-associated myelopathy or chronic progressive... more...

Description from OMIM:47 159580

Aliases & Classifications for Tropical Spastic Paraparesis

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 49Orphanet, 47OMIM, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal, Immune


Characteristics (Orphanet epidemiological data):

49
tropical spastic paraparesis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

tropical spastic paraparesis 8 44 10 49 47 61
human t-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis 49
human t-lymphotropic virus type i-associated myelopathy/tropical spastic paraparesis 49
htlv-1-associated myelopathy/tropical spastic paraparesis 49
paraparesis tropical spastic 45
tropical spastic paraplegia 8
htlv-associated myelopathy 8
tropical spastic paralysis 8
ham/tsp 49
tsp 49


External Ids:

Disease Ontology8 DOID:321
OMIM47 159580
MeSH35 D015493
SNOMED-CT57 192733005, 45129002
ICD10 via Orphanet26 G04.1
ICD1025 G04.1

Related Diseases for Tropical Spastic Paraparesis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Clinical Features for Tropical Spastic Paraparesis

Sources:
47OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

159580

Clinical synopsis from OMIM:

159580

Symptoms:

8 (see all 4)
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

Drugs & Therapeutics for Tropical Spastic Paraparesis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Tropical Spastic Paraparesis

Drug clinical trials:

Search ClinicalTrials for Tropical Spastic Paraparesis

Search NIH Clinical Center for Tropical Spastic Paraparesis

Search CenterWatch for Tropical Spastic Paraparesis

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

33
Spinal cord, Thymus, Brain, Skeletal muscle, Thyroid, Breast, Nk cells, T cells, B cells

FMA organs/tissues related to Tropical Spastic Paraparesis:

14
Spinal cord

Animal Models for Tropical Spastic Paraparesis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Tropical Spastic Paraparesis

Sources:
51PubMed
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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine). (23477875)
2013
2
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. (22720101)
2012
3
Khorasan Disease: Prevalence of HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) In West Azarbaijan from 2004 to 2007. (22737507)
2011
4
Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients. (20087941)
2010
5
Therapeutic strategies in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (20021347)
2009
6
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis. (19438598)
2009
7
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? (19936247)
2009
8
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
9
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
10
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
11
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16503269)
2006
12
Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state. (16879249)
2006
13
Flow cytometry evaluation of the T-cell receptor Vbeta repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals: effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (16545396)
2006
14
Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (15655786)
2005
15
Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (16258633)
2005
16
Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy. (15785836)
2005
17
Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis. (16338746)
2005
18
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. (15722539)
2005
19
Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1-coinfected patients. (16107970)
2005
20
Defective human T-cell lymphotropic virus type I (HTLV-I) provirus in seronegative tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) patients. (12573502)
2003
21
Dermatological findings of human T lymphotropic virus type 1 (HTLV-I)-associated myelopathy/tropical spastic paraparesis. (12567310)
2003
22
Neuropathology of two Brazilian autopsied cases of tropical spastic paraparesis / HTLV-I associated myelopathy (TSP/HAM) of long evolution. (12244385)
2002
23
Detection of myelin basic protein in cerebrospinal fluid and serum from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (12564844)
2002
24
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
25
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. (10967179)
2000
26
Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis. (11010842)
2000
27
Multiple sclerosis and HTLV-I associated myelopathy/tropical spastic paraparesis are two distinct clinical entities. (9345386)
1996
28
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. (8912212)
1996
29
Tropical spastic paraparesis/HTLV-I-associated myelopathy in Europe and in Africa: clinical and epidemiologic aspects. (8797702)
1996
30
Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/lymphoma. (8877061)
1996
31
High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis. (8599198)
1996
32
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives. (8563108)
1995
33
Human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in SALo Paulo, Brazil. (7548506)
1995
34
What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? (7847855)
1995
35
Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor V beta CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. (8064235)
1994
36
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. (8213080)
1993
37
The risk of tropical spastic paraparesis differs according to ethnic group among HTLV-I carriers in Inongo, Zaire. (8509984)
1993
38
HTLV-I DNA sequences in CNS tissue of a patient with tropical spastic paraparesis and HTLV-I-associated myelopathy. (1517966)
1992
39
Multiple sclerosis, tropical spastic paraparesis and HTLV-I infection. (1619436)
1992
40
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
41
Natural killer (NK) cells in HTLV-I-associated myelopathy/tropical spastic paraparesis-decrease in NK cell subset populations and activity in HTLV-I seropositive individuals. (2066395)
1991
42
Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom. (1940939)
1991
43
Tropical spastic paraparesis in Brazil. (1671154)
1991
44
Methylprednisolone therapy in tropical spastic paraparesis. (2313308)
1990
45
Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates. (2304144)
1990
46
Molecular analysis of HTLV-I proviral integration and T cell receptor arrangement indicates that T cells in tropical spastic paraparesis are polyclonal. (2538520)
1989
47
Tropical spastic paraparesis. A clinical study of 50 patients from Tumaco (Colombia) and review of the worldwide features of the syndrome. (3193122)
1988
48
Tropical spastic paraparesis associated with human T lymphotropic virus type I in an east African naturalised in Sweden. (2891399)
1987
49
Tropical spastic paraparesis. (3729320)
1986
50
HTLV-I and tropical spastic paraparesis in Africa. (2876179)
1986

Genetic Variations for Tropical Spastic Paraparesis

Expression for genes affiliated with Tropical Spastic Paraparesis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

Compounds for genes affiliated with Tropical Spastic Paraparesis

GO Terms for genes affiliated with Tropical Spastic Paraparesis

Products for genes affiliated with Tropical Spastic Paraparesis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Tropical Spastic Paraparesis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet