MCID: TRP002
MIFTS: 57

Tropical Spastic Paraparesis malady

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tropical Spastic Paraparesis

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Aliases & Descriptions for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 11 49 13 68
Paraparesis, Tropical Spastic 39
Paraparesis Tropical Spastic 50
 
Tropical Spastic Paraplegia 11
Htlv-Associated Myelopathy 11
Tropical Spastic Paralysis 11

Classifications:



External Ids:

Disease Ontology11 DOID:321
ICD1030 G04.1
MeSH39 D015493

Summaries for Tropical Spastic Paraparesis

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NINDS:49 For several decades the term ?tropical spastic paraparesis? (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus ? human T-cell lymphotrophic virus type 1 (also known as HTLV-1) ? and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary: Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to systemic lupus erythematosus and htlv-1 associated myelopathy/tropical spastic paraparesis, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways are Inflammatory Response Pathway and IL12 signaling mediated by STAT4. Affiliated tissues include spinal cord, t cells and spinal cord, and related mouse phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and neoplasm.

Disease Ontology:11 A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia:71 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

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Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus27.2CCL5, CXCR3, GATA3, IFNG, IL10, IL2
2htlv-1 associated myelopathy/tropical spastic paraparesis12.4
3myelopathy, htlv-1-associated12.0
4retrovirus-associated myelopathy11.4
5spastic paraparesis11.2
6spasticity11.2
7leukemia10.6
8t-cell leukemia10.6
9bulbospinal polio10.6IFNG, IL2
10thelaziasis10.5IFNG, IL10
11motor peripheral neuropathy10.5IFNG, IL2RA
12panner disease10.5IFNG, IL6
13anthracosilicosis10.5IFNG, IL2
14predominantly cortical thymoma10.5IL10, IL6
15addison's disease10.5IFNG, IL10, IL2
16calcifying epithelial odontogenic tumor10.5IFNG, IL10, IL2
17pneumonic tularemia10.5IFNG, IL10, IL2
18eye accommodation disease10.5IFNG, IL10, IL2RA
19collagen disease10.5IFNG, IL10, IL2
20hypospadias10.5IFNG, IL10, IL2
21chronic hiccups10.5IFNG, IL10, IL2RA
22pediatric t-cell leukemia10.5IL10, IL2
23dengue disease10.4IFNG, IL10, IL2
24maligant granulosa cell tumor of ovary10.4IL2, IL6
25hereditary conventional renal cell carcinoma10.4IFNG, IL10, IL2
26variola minor10.4IFNG, IL10, IL2
27herpangina10.4IFNG, IL10, IL6
28idiopathic neutropenia10.4IFNG, IL10, IL6
29scn8a encephalopathy10.4IFNG, IL10, IL6
30potter's syndrome10.4IFNG, IL2, IL2RA
31mastocytosis cutaneous with short stature conductive hearing loss and microtia10.4IFNG, IL10, IL6
32hemophagocytic lymphohistiocytosis10.4IFNG, IL10, IL6
33leukostasis10.4IFNG, IL10, IL6
34dementia - subcortical10.4IFNG, IL10, IL6
35uterine corpus dissecting leiomyoma10.4IFNG, IL10, IL2
36oesophagostomiasis10.4IFNG, IL10, IL6
37gastric dilatation10.4IFNG, IL10, IL6
38bile duct signet ring cell carcinoma10.4IFNG, IL10, IL6
39ehlers-danlos syndrome, musculocontractural type10.4IFNG, IL10, IL6
40orbital periostitis10.4IFNG, IL10, IL6
41corneal intraepithelial neoplasm10.4IFNG, IL10, IL6
42melioidosis10.4IFNG, IL10, IL6
43reproductive system disease10.4IFNG, IL10, IL6
44spondylolysis10.4IFNG, IL10, IL6
45parainfluenza virus type 310.4CNTN2, IFNG, NFKB1
46pulmonary systemic sclerosis10.4IFNG, IL10, IL2RA
47adult t-cell leukemia10.4
48solitary osseous plasmacytoma10.4IL2, IL6
49toxic maculopathy10.4IFNG, IL2, IL2RA
50dentinogenesis imperfecta10.4IFNG, IL10, IL6

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to tropical spastic paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

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Symptoms:

 11 (show all 4)
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

UMLS symptoms related to Tropical Spastic Paraparesis:


hemiparesis, hemiplegia, paresis, paraparesis, todd paralysis, quadriparesis, monoparesis, paresis anal sphincter

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00224-A-29.9MMP9, NFKB1, TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

41 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CXCR3, IFNG, IL10, IL2, IL6, MMP9
2MP:00053708.9IFNG, IL10, IL2, IL6, NFKB1, TNFRSF4
3MP:00053888.2CXCR3, IFNG, IL10, IL2, IL6, MMP9
4MP:00053678.0CX3CR1, CXCR3, GATA3, IFNG, IL6, MMP9
5MP:00053917.9CX3CR1, GATA3, IFNG, IL10, IL6, MMP9
6MP:00028737.8CX3CR1, CXCR3, GATA3, IFNG, IL10, NFKB1
7MP:00107717.7CX3CR1, GATA3, IFNG, IL10, IL6, MMP9
8MP:00053857.4CX3CR1, CXCR3, GATA3, IFNG, IL10, IL2
9MP:00053817.2CX3CR1, IFNG, IL10, IL2, IL2RA, IL6
10MP:00036317.1CNTN2, CX3CR1, GATA3, IFNG, IL10, IL6
11MP:00053766.7CX3CR1, CXCR3, GATA3, IFNG, IL10, IL2
12MP:00107686.5CX3CR1, CXCR3, GATA3, IFNG, IL10, IL2
13MP:00053846.5CX3CR1, CXCR3, GATA3, IFNG, IL10, IL2
14MP:00053786.4CX3CR1, GATA3, IFNG, IL10, IL2, IL2RA
15MP:00053875.0CCL5, CX3CR1, CXCR3, GATA3, IFNG, IFNL3
16MP:00053974.9CCL5, CX3CR1, CXCR3, GATA3, IFNG, IFNL3

Drugs & Therapeutics for Tropical Spastic Paraparesis

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Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pentoxifyllineapproved, investigationalPhase 3996493-05-64740
Synonyms:
1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
1-(5-Oxohexyl)-3,7-dimethylxanthine
1-(5-Oxohexyl)theobromine
2a3c
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl) xantine
3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
3,7-Dimethyl-1-(5-oxohexyl)xanthine
3,7-Dimethyl-1-(5-oxohexyl)xantine
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
5-26-14-00081 (Beilstein Handbook Reference)
6493-05-6
AB00052363
AC1L1IUN
AKOS000541484
Agapurin
Agapurin Retard
Azupentat
BAS 00897429
BB_SC-2111
BIDD:GT0174
BL 191
BL-191
BL191
BPBio1_000167
BRD-K57569181-001-05-1
BRN 0558929
BSPBio_000151
BSPBio_003439
C07424
C13H18N4O3
CAS-1677687
CCRIS 6832
CHEMBL628
CID4740
CPD000035998
D00501
D010431
DB00806
Dimethyloxohexylxanthine
DivK1c_000729
Durapental
EHT 0201
EHT-0201
EHT-201
EHT0201
EINECS 229-374-5
EU-0100936
HMS1568H13
HMS1922E16
HMS2051N06
HMS2090H13
HMS2093G21
HMS502E11
Hemovas
I06-1592
IDI1_000729
IN1161
Ikomio
KBio1_000729
KBio2_001924
KBio2_004492
KBio2_007060
KBio3_002942
KBioGR_000893
KBioSS_001924
LS-149385
 
Lopac-P-1784
Lopac0_000936
MLS000079026
MLS000758298
MLS001201764
MolPort-001-823-263
NCGC00015801-01
NCGC00015801-02
NCGC00015801-04
NCGC00015801-10
NCGC00067069-02
NCGC00067069-03
NCGC00067069-04
NCGC00067069-05
NCGC00178062-01
NCGC00178062-02
NINDS_000729
NSC 637086
NSC637086
Oxpentifylline
P 1784
PDSP1_001015
PDSP2_000999
PENTOXYPHYLINE
PNX
Pentoxifilina
Pentoxifilina [INN-Spanish]
Pentoxifyllin
Pentoxifylline
Pentoxifylline (JAN/USP/INN)
Pentoxifylline [USAN:INN:JAN]
Pentoxifyllinum
Pentoxifyllinum [INN-Latin]
Pentoxil
Pentoxil (TN)
Pentoxiphyllin
Pentoxiphylline
Pentoxiphyllium
Pentoxyfylline
Pentoxyphyllin
Pentoxyphylline
Prestwick0_000196
Prestwick1_000196
Prestwick2_000196
Prestwick3_000196
Prestwick_608
Px
Ralofect
Rentylin
SAM001247011
SMR000035998
SPBio_001221
SPBio_002072
SPECTRUM1503611
SR-01000075641-4
STK177321
Spectrum2_001181
Spectrum3_001820
Spectrum4_000227
Spectrum5_001161
Spectrum_001444
Torental
Trental
Trental (TN)
UNII-SD6QCT3TSU
Vasofirin
Vazofirin
ZINC01530776
cis-9-Octadecenoyl coenzyme A
pentoxifylline
2
Valproic Acidapproved, investigationalPhase 332299-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propyl-pentanoic acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VPA
Valcote
Valparin
Valproate
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
acide valproïque
acidum valproicum
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
ácido valproico
3
Cyclosporineapproved, investigational, vet_approvedPhase 2, Phase 391579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
4
Miconazoleapproved, investigational, vet_approvedPhase 2, Phase 3362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
5
Lamivudineapproved, investigationalPhase 2, Phase 3613134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
 
DB00709
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
6
ZidovudineapprovedPhase 2, Phase 3, Early Phase 149430516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
 
CPD000058351
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
7Anti-HIV AgentsPhase 2, Phase 3, Early Phase 13100
8Neurotransmitter AgentsPhase 317734
9Vasodilator AgentsPhase 33438
10GABA AgentsPhase 31622
11Radiation-Protective AgentsPhase 3466
12Tranquilizing AgentsPhase 34164
13Platelet Aggregation InhibitorsPhase 32419
14Central Nervous System DepressantsPhase 312806
15AntioxidantsPhase 32928
16Protective AgentsPhase 37190
17Phosphodiesterase InhibitorsPhase 31254
18Psychotropic DrugsPhase 36279
19Antiviral AgentsPhase 2, Phase 3, Early Phase 19732
20Nucleic Acid Synthesis InhibitorsPhase 2, Phase 3, Early Phase 14855
21Anti-Retroviral AgentsPhase 2, Phase 3, Early Phase 13232
22AntimetabolitesPhase 2, Phase 3, Early Phase 111774
23Antimanic AgentsPhase 3790
24Reverse Transcriptase InhibitorsPhase 2, Phase 3, Early Phase 11880
25Anti-Infective AgentsPhase 2, Phase 3, Early Phase 121402
26AnticonvulsantsPhase 32620
27Antifungal AgentsPhase 2, Phase 33615
28Dermatologic AgentsPhase 2, Phase 35674
29Immunosuppressive AgentsPhase 2, Phase 312770
30Antirheumatic AgentsPhase 2, Phase 310627
31Calcineurin InhibitorsPhase 2, Phase 31597
32
Interferon beta-1aapproved, investigationalPhase 2198145258-61-36438354
Synonyms:
145258-61-3
Avonex
Avonex (TN)
Belerofon
D04554
 
Fibroblast interferon
IFN-beta
Interferon beta precursor
Interferon beta-1a
Interferon beta-1a (USAN)
Interferon beta-1a (genetical recombination)
Interferon beta-1a (genetical recombination) (JAN)
33
InfliximabapprovedPhase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
34interferonsPhase 22137
35Interferon-betaPhase 2280
36Adjuvants, ImmunologicPhase 22484
37Gastrointestinal AgentsPhase 28109
38ImmunoglobulinsPhase 16045
39Antibodies, MonoclonalPhase 13795
40AntibodiesPhase 16045
41Raltegravir PotassiumEarly Phase 1291
42HIV Integrase InhibitorsEarly Phase 1387
43Integrase InhibitorsEarly Phase 1408

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)Unknown statusNCT01343355Phase 2, Phase 3
2Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised TrialCompletedNCT00272480Phase 2, Phase 3
3Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)CompletedNCT00773292Phase 2, Phase 3
4Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)CompletedNCT00681980Phase 3
5Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) DiseasesCompletedNCT01472263Phase 3
6Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)CompletedNCT00001785Phase 2
7The HAM Infliximab StudyTerminatedNCT00823641Phase 2
8Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisRecruitingNCT00076843Phase 1
9Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM)RecruitingNCT02961712Phase 1
10Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1Unknown statusNCT01754311
11Evaluation of the MP Diagnostics HTLV Blot 2.4Unknown statusNCT01467024
12MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic ParaparesisCompletedNCT00034723
13A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective DermatitisCompletedNCT00340821
14Assessment of Patients With Multiple Sclerosis (MS)CompletedNCT00001156
15Raltegravir for HAM/TSPRecruitingNCT01867320Early Phase 1
16Evaluation of Patients With HAM/TSPRecruitingNCT00001778
17Urological Physical Therapy in HTLV-1 With Urinary SymptomsEnrolling by invitationNCT01651819
18Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionNot yet recruitingNCT02655471Early Phase 1
19Safety and Efficiency Study of Valproic Acid In HAM/TSPTerminatedNCT00519181

Search NIH Clinical Center for Tropical Spastic Paraparesis


Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

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Anatomical Context for Tropical Spastic Paraparesis

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MalaCards organs/tissues related to Tropical Spastic Paraparesis:

36
T cells, Spinal cord, Skin, Eye, Lung, Brain, Nk cells

FMA organs/tissues related to Tropical Spastic Paraparesis:

17
Spinal cord

Publications for Tropical Spastic Paraparesis

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Articles related to Tropical Spastic Paraparesis:

(show top 50)    (show all 405)
idTitleAuthorsYear
1
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. (27845163)
2017
2
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. (27894665)
2017
3
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. (27777805)
2016
4
Clonus Associated with Tropical Spastic Paraparesis. (27783915)
2016
5
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (26756420)
2016
6
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. (27449667)
2016
7
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. (27871430)
2016
8
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (27028551)
2016
9
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. (26472535)
2015
10
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (26174324)
2015
11
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. (25760424)
2015
12
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. (26241614)
2015
13
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. (27500208)
2015
14
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. (25833232)
2015
15
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. (26169165)
2015
16
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. (26077665)
2015
17
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (25820278)
2015
18
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (25470342)
2015
19
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. (25820277)
2015
20
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. (26283355)
2015
21
HTLV-1-associated myelopathy/tropical spastic paraparesis. (27188208)
2015
22
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. (26392440)
2015
23
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25884435)
2015
24
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. (26609200)
2015
25
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. (26156876)
2015
26
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. (25229227)
2014
27
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. (24802839)
2014
28
Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis. (24603733)
2014
29
Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (24815740)
2014
30
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). (24704970)
2014
31
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. (25233462)
2014
32
HTLV-I associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. (25196582)
2014
33
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. (24472094)
2014
34
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (25227931)
2014
35
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3-Dimensional MR Images. (22303896)
2014
36
Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients. (24321043)
2014
37
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
38
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (23651542)
2013
39
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. (23568138)
2013
40
Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23022356)
2013
41
Contribution of Galvanic Vestibular Stimulation for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (24285967)
2013
42
Neuroimmunological aspects of human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis. (23943469)
2013
43
CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. (24130912)
2013
44
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (23932323)
2013
45
Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. (23756056)
2013
46
The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (24470869)
2013
47
Effects of Danazol on Clinical Improvement of Patients with Human T-cell Lymphotropic Virus Type I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): A Placebo-Controlled Clinical Trial. (24470864)
2013
48
Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine). (23477875)
2013
49
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. (23278610)
2013
50
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. (23924924)
2013

Variations for Tropical Spastic Paraparesis

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Expression for genes affiliated with Tropical Spastic Paraparesis

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Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for genes affiliated with Tropical Spastic Paraparesis

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Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idSuper pathwaysScoreTop Affiliating Genes
19.7IFNG, IL2, IL2RA
29.7IFNG, IL2, IL2RA
39.6IFNG, IL2, NFKB1
4
Show member pathways
9.6IL2, IL2RA, NFKB1
5
Show member pathways
9.6IL2, IL2RA, NFKB1
6
Show member pathways
9.6IL2, IL2RA, NFKB1
79.6IFNG, IL10, IL6
89.6IFNG, IL10, IL6
9
Show member pathways
9.5IFNG, IL6, NFKB1
109.5IFNG, IL6, NFKB1
119.5IL6, MMP9, NFKB1
129.5IL6, MMP9, NFKB1
139.5IL2RA, IL6, NFKB1
149.5IL10, IL6, NFKB1
159.5IL10, IL6, NFKB1
16
Show member pathways
9.4IFNG, IL10, IL2, IL2RA
179.4CCL5, MMP9
189.4IFNG, IL2, IL6, MMP9
19
Show member pathways
9.3IFNG, IL10, IL2, IL6
209.3IFNG, IL10, IL2, IL6
21
Show member pathways
9.3IFNG, IL2, IL2RA, NFKB1
22
Show member pathways
9.3IFNG, IL2, IL2RA, TNFRSF4
239.3IFNG, IL2, IL6, NFKB1
249.2IFNG, IL6, MMP9, NFKB1
259.2IL2, IL2RA, IL6, NFKB1
269.2IL2, IL2RA, IL6, NFKB1
279.2IFNG, IL10, IL6, NFKB1
289.2IFNG, IL10, IL6, NFKB1
29
Show member pathways
9.1GATA3, IFNG, IL2, IL2RA
309.1CCL5, IFNG, IL6
319.1IFNG, IL10, IL2, IL2RA, IL6
32
Show member pathways
9.0IFNG, IL10, IL2, IL2RA, NFKB1
33
Show member pathways
9.0IFNG, IL10, IL2, IL6, NFKB1
348.9IFNG, IL10, IL2, NFKB1, TNFRSF4
358.8GATA3, IL10, IL6, NFKB1
368.8CX3CR1, IFNG, IL10, IL2, IL6
378.8CCL5, IL10, IL2, IL6
388.8IL10, IL2RA, IL6, NFKB1, TNFRSF4
39
Show member pathways
8.7GATA3, IFNG, IL10, IL2, IL6
408.7CCL5, IL6, MMP9, NFKB1
418.6GATA3, IFNG, IL2, IL6, NFKB1
428.5CX3CR1, IFNG, IL10, IL2, IL2RA, IL6
438.4GATA3, IFNG, IL10, IL2, IL2RA, TNFRSF4
44
Show member pathways
8.3GATA3, IFNG, IL10, IL2, IL6, NFKB1
45
Show member pathways
8.3GATA3, IFNG, IL10, IL2, IL6, NFKB1
468.3CXCR3, GATA3, IFNG, IL10, IL2, IL2RA
47
Show member pathways
8.2CCL5, IFNG, IL10, IL2, IL2RA, IL6
48
Show member pathways
8.2CCL5, IFNG, IL2, IL2RA, IL6, NFKB1
49
Show member pathways
7.9CCL5, IFNG, IL10, IL2, IL6, MMP9
50
Show member pathways
7.9CCL5, IFNG, IL10, IL2, IL2RA, IL6

GO Terms for genes affiliated with Tropical Spastic Paraparesis

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Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.9CXCR3, IFNG, IL2RA, IL6
2neuron projectionGO:00430058.6CNTN2, CX3CR1, IFNG, NFKB1, PTPN13
3extracellular spaceGO:00056158.5CCL5, IFNG, IFNL3, IL10, IL2, IL6

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:004830410.7IFNG, IL2
2negative regulation of lymphocyte proliferationGO:005067210.7IL2, IL2RA
3negative regulation of growth of symbiont in hostGO:004413010.7IFNG, IL10
4positive regulation of MHC class II biosynthetic processGO:004534810.7IFNG, IL10
5neutrophil apoptotic processGO:000178110.6IFNG, IL6
6regulation of T cell homeostatic proliferationGO:004601310.6IL2, IL2RA
7cellular response to hepatocyte growth factor stimulusGO:003572910.6IL10, IL6
8defense response to protozoanGO:004283210.4IFNG, IL10, IL6
9positive regulation of immunoglobulin secretionGO:005102410.2IL2, IL6, TNFRSF4
10positive regulation of T cell differentiationGO:004558210.1GATA3, IL2, IL2RA
11humoral immune responseGO:000695910.0GATA3, IFNG, IL6
12immune responseGO:000695510.0IL10, IL2, IL2RA, TNFRSF4
13regulation of T cell activationGO:005086310.0CCL5, IFNL3
14macrophage chemotaxisGO:00482469.9CCL5, CX3CR1
15positive regulation of neuron differentiationGO:00456669.8CCL5, IFNG, IL6
16positive regulation of JAK-STAT cascadeGO:00464279.8CCL5, IL10, IL6
17cellular response to interleukin-1GO:00713479.7CCL5, IL6, NFKB1
18negative regulation of apoptotic processGO:00430669.7IL10, IL2, IL6, MMP9, NFKB1
19response to glucocorticoidGO:00513849.6CCL5, IL10, IL6
20response to insulinGO:00328689.5CCL5, IL10, IL6
21cellular response to lipopolysaccharideGO:00712229.5CX3CR1, IFNG, IL10, IL6, NFKB1
22chemokine-mediated signaling pathwayGO:00700989.5CCL5, CX3CR1, CXCR3
23chemotaxisGO:00069359.5CCL5, CX3CR1, CXCR3
24negative regulation of inflammatory responseGO:00507289.4GATA3, IL10, IL2, IL2RA, NFKB1
25positive regulation of T cell proliferationGO:00421029.3CCL5, IFNG, IL2, IL2RA, IL6
26positive regulation of transcription, DNA-templatedGO:00458939.2GATA3, IFNG, IL10, IL6, NFKB1
27cellular response to tumor necrosis factorGO:00713569.1CCL5, GATA3, IL6, NFKB1
28positive regulation of transcription from RNA polymerase II promoterGO:00459449.0GATA3, IFNG, IL10, IL2, IL6, NFKB1
29response to virusGO:00096158.8CCL5, GATA3, IFNG
30response to drugGO:00424938.7CCL5, GATA3, IFNG, IL10, IL6
31inflammatory responseGO:00069548.2CCL5, CXCR3, IL10, IL2RA, IL6, NFKB1

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:000495010.1CX3CR1, CXCR3
2interleukin-2 receptor bindingGO:00051349.6GATA3, IL2
3cytokine activityGO:00051259.1IFNG, IFNL3, IL10, IL2, IL6

Sources for Tropical Spastic Paraparesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet