MCID: TRP002
MIFTS: 55

Tropical Spastic Paraparesis malady

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tropical Spastic Paraparesis

Aliases & Descriptions for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 12 51 14 69
Paraparesis, Tropical Spastic 42
Paraparesis Tropical Spastic 52
Tropical Spastic Paraplegia 12
Htlv-Associated Myelopathy 12
Tropical Spastic Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:321
ICD10 33 G04.1
MeSH 42 D015493
UMLS 69 C0030481

Summaries for Tropical Spastic Paraparesis

NINDS : 51 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to htlv-1 associated myelopathy/tropical spastic paraparesis and myelopathy, htlv-1-associated, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cyclosporine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, breast and spinal cord, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results_in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia : 71 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
id Related Disease Score Top Affiliating Genes
1 htlv-1 associated myelopathy/tropical spastic paraparesis 12.5
2 myelopathy, htlv-1-associated 12.0
3 human t-cell leukemia virus type 1 11.4
4 retrovirus-associated myelopathy 11.4
5 spasticity 11.2
6 spastic paraparesis 11.2
7 leukemia 10.6
8 t-cell leukemia 10.6
9 adult t-cell leukemia 10.4
10 dermatitis 10.3
11 lymphoma 10.3
12 paralytic poliomyelitis 10.3 IFNG IL2
13 parametritis 10.3 IFNG IL2 IL2RA
14 caplan's syndrome 10.3 IFNG IL2
15 central nervous system origin vertigo 10.3 IFNG IL2 IL2RA
16 venezuelan hemorrhagic fever 10.2 CXCR3 IFNG IL2
17 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG IL2
18 periodontosis 10.2 IFNG IL2 IL2RA
19 asymptomatic neurosyphilis 10.2 IFNG IL10 IL2RA
20 plantar wart 10.2 IFNG IL10 IL2
21 ciliary discoordination, due to random ciliary orientation 10.2 IFNG IL10 IL2RA
22 chronic thromboembolic pulmonary hypertension 10.2 IFNG IL10 IL2
23 multiple carboxylase deficiency 10.2 IFNG IL2 IL2RA
24 tularemia 10.2 IFNG IL10 IL2
25 microcephaly 10.2 IFNG IL10 IL2
26 abnormal retinal correspondence 10.2 IFNG IL10 IL2
27 oropharynx cancer 10.2 IFNG IL10 IL2
28 neuropathy 10.2
29 hutchinson incisors 10.2 CNTN2 IFNG NFKB1
30 dengue hemorrhagic fever 10.2 IFNG IL10 IL2
31 pre-malignant neoplasm 10.2 IFNG IL2 IL2RA
32 liver inflammatory pseudotumor 10.2 IFNG IL10 IL2
33 balkan nephropathy 10.2 CXCR3 IFNG IL10
34 childhood choriocarcinoma of the testis 10.2 IL10 IL2 IL2RA
35 benign eccrine breast spiradenoma 10.2 CXCR3 IFNG IL10
36 uterus interstitial leiomyoma 10.2 IFNG IL10 IL2
37 clostridium difficile colitis 10.2 IFNG IL2 IL6
38 spastic paraplegia 19 10.2 CX3CR1 IFNG IFNL3 IL2
39 cutaneous fibrous histiocytoma 10.2 CCL5 IFNG IL2RA
40 alcoholic liver cirrhosis 10.2 CNTN2 IL2 IL2RA
41 respiratory system disease 10.1 IFNG IL10 IL2RA
42 neonatal stroke 10.1 IFNG IL10 IL2
43 t-cell prolymphocytic leukemia 10.1 CXCR3 IL2RA
44 autosomal dominant robinow syndrome 3 10.1 IL10 IL2 IL2RA
45 nasopharyngitis 10.1 IFNG IL2 IL6
46 immune-complex glomerulonephritis 10.1 CXCR3 IFNG IL6
47 thyroid hyalinizing trabecular adenoma 10.1 IFNG IL2 IL6
48 hyperaldosteronism, familial, type ii 10.1 CCL5 IL2 IL2RA
49 periarthritis 10.1 IFNG IL10 IL2
50 heart conduction disease 10.1 IFNG IL10 IL2 IL2RA

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to Tropical Spastic Paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

Symptoms:

12
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.8 MMP9 NFKB1 TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 IFNG IFNL3 IL10 IL2 IL2RA IL6
2 immune system MP:0005387 10.32 CCL5 CX3CR1 CXCR3 GATA3 IFNG IFNL3
3 cellular MP:0005384 10.29 IL10 IL2 IL6 MMP9 NFKB1 PTPN13
4 growth/size/body region MP:0005378 10.26 CX3CR1 GATA3 IFNG IL10 IL2 IL2RA
5 digestive/alimentary MP:0005381 10.24 IL2 IL2RA IL6 MMP9 NFKB1 TNFRSF4
6 homeostasis/metabolism MP:0005376 10.24 IFNG IL10 IL2 IL2RA IL6 MMP9
7 cardiovascular system MP:0005385 10.16 CX3CR1 CXCR3 GATA3 IFNG IL10 IL2
8 mortality/aging MP:0010768 10.14 CX3CR1 CXCR3 IL6 MMP9 NFKB1 TNFRSF4
9 integument MP:0010771 10.06 CX3CR1 GATA3 IFNG IL10 IL6 MMP9
10 liver/biliary system MP:0005370 9.91 IFNG IL10 IL2 IL6 NFKB1 TNFRSF4
11 muscle MP:0005369 9.91 CX3CR1 GATA3 IFNG IL10 IL6 MMP9
12 nervous system MP:0003631 9.91 CNTN2 CX3CR1 GATA3 IFNG IL10 IL6
13 neoplasm MP:0002006 9.8 CXCR3 IFNG IL10 IL2 IL6 MMP9
14 renal/urinary system MP:0005367 9.63 GATA3 IFNG IL6 MMP9 CX3CR1 CXCR3
15 respiratory system MP:0005388 9.61 CXCR3 IFNG IL10 IL2 IL2RA IL6
16 vision/eye MP:0005391 9.28 CX3CR1 GATA3 IFNG IL10 IL2 IL2RA

Drugs & Therapeutics for Tropical Spastic Paraparesis

Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 2, Phase 3 79217-60-0, 59865-13-3 5284373 6435893
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
4
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
7 GABA Agents Phase 3
8 Neurotransmitter Agents Phase 3
9 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
10 Dermatologic Agents Phase 2, Phase 3
11 Tranquilizing Agents Phase 3
12 Vasodilator Agents Phase 3
13 Phosphodiesterase Inhibitors Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
16 Anti-Infective Agents Phase 2, Phase 3, Early Phase 1
17 Immunosuppressive Agents Phase 2, Phase 3
18 Anticonvulsants Phase 3
19 Protective Agents Phase 3
20 Antifungal Agents Phase 2, Phase 3
21 Psychotropic Drugs Phase 3
22 Antimanic Agents Phase 3
23 Radiation-Protective Agents Phase 3
24 Antimetabolites Phase 2, Phase 3,Early Phase 1
25 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
26 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
27 Antirheumatic Agents Phase 2, Phase 3
28 Calcineurin Inhibitors Phase 2, Phase 3
29 Antiviral Agents Phase 2, Phase 3,Early Phase 1
30 Antioxidants Phase 3
31 Central Nervous System Depressants Phase 3
32
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
33
Infliximab Approved Phase 2 170277-31-3
34 interferons Phase 2
35 Adjuvants, Immunologic Phase 2
36 Interferon-beta Phase 2
37 Gastrointestinal Agents Phase 2
38 Immunoglobulins Phase 1
39 Antibodies, Monoclonal Phase 1
40 Antibodies Phase 1
41 HIV Integrase Inhibitors Early Phase 1
42 Integrase Inhibitors Early Phase 1
43 Raltegravir Potassium Early Phase 1

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3
2 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3
3 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3
4 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3
5 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3
6 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2
7 The HAM Infliximab Study Terminated NCT00823641 Phase 2
8 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Recruiting NCT00076843 Phase 1
9 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
10 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Unknown status NCT01754311
11 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
12 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
13 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
14 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
15 Raltegravir for HAM/TSP Recruiting NCT01867320 Early Phase 1
16 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
17 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Enrolling by invitation NCT01651819
18 Dual Algorithm Post Market Clinical Study Enrolling by invitation NCT03146013
19 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Not yet recruiting NCT02655471 Early Phase 1
20 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181

Search NIH Clinical Center for Tropical Spastic Paraparesis

Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

39
T Cells, Breast, Spinal Cord, Lung, Skin, Eye, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Tropical Spastic Paraparesis:

18
Spinal Cord

Publications for Tropical Spastic Paraparesis

Articles related to Tropical Spastic Paraparesis:

(show top 50) (show all 406)
id Title Authors Year
1
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
2
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
3
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
4
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
5
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
6
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
7
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
8
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
9
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
10
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
11
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
12
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2015
13
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. ( 25833232 )
2015
14
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. ( 27500208 )
2015
15
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
16
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
17
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
18
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
19
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
20
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
21
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
22
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
23
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25760424 )
2015
24
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2015
25
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
26
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
27
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
28
HTLV-I associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. ( 25196582 )
2014
29
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
30
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. ( 25233462 )
2014
31
Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients. ( 24321043 )
2014
32
Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis. ( 24603733 )
2014
33
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24704970 )
2014
34
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
35
Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24815740 )
2014
36
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
37
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3-Dimensional MR Images. ( 22303896 )
2014
38
Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4(+) T Cells in Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients. ( 24041428 )
2013
39
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 23165507 )
2013
40
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. ( 23568138 )
2013
41
Effects of Danazol on Clinical Improvement of Patients with Human T-cell Lymphotropic Virus Type I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): A Placebo-Controlled Clinical Trial. ( 24470864 )
2013
42
Contribution of Galvanic Vestibular Stimulation for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 24285967 )
2013
43
Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 23945332 )
2013
44
Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. ( 23756056 )
2013
45
Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial. ( 23945290 )
2013
46
Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad). ( 24470873 )
2013
47
Tropical spastic paraparesis treated with Combivir (lamivudine-zidovudine). ( 23477875 )
2013
48
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. ( 23924924 )
2013
49
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 23651542 )
2013
50
Incidence of human T cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in a long-term prospective cohort study of initially asymptomatic individuals in Brazil. ( 23617363 )
2013

Variations for Tropical Spastic Paraparesis

Expression for Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for Tropical Spastic Paraparesis

Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL5 GATA3 IFNG IFNL3 IL10 IL2
2
Show member pathways
13.85 CCL5 CX3CR1 CXCR3 IL10 IL2 IL2RA
3
Show member pathways
13.62 CCL5 CX3CR1 CXCR3 IFNG IFNL3 IL10
4
Show member pathways
13.52 CCL5 IFNG IL10 IL2 IL2RA IL6
5
Show member pathways
13.39 CCL5 CX3CR1 CXCR3 IL10 IL2 IL2RA
6
Show member pathways
13.17 CCL5 CX3CR1 CXCR3 IL10 IL2 IL2RA
7
Show member pathways
13.17 CCL5 GATA3 IFNG IFNL3 IL10 IL2
8
Show member pathways
12.92 CCL5 IFNG IL10 IL2 IL6 MMP9
9
Show member pathways
12.86 IFNG IL10 IL2 IL2RA IL6
10
Show member pathways
12.79 CCL5 IFNG IL2 IL2RA IL6 NFKB1
11
Show member pathways
12.74 CCL5 IFNG IFNL3 IL6 NFKB1
12
Show member pathways
12.65 IFNG IL10 IL2 IL2RA NFKB1
13
Show member pathways
12.61 IFNG IL10 IL2 IL6 NFKB1
14
Show member pathways
12.59 GATA3 IFNG IL10 IL2 IL2RA IL6
15 12.57 IL2 IL2RA IL6 NFKB1
16
Show member pathways
12.46 GATA3 IFNG IL10 IL2 IL6 NFKB1
17 12.43 IL2 IL2RA IL6 NFKB1
18
Show member pathways
12.35 CCL5 IFNG IL2 IL6 NFKB1
19
Show member pathways
12.34 IFNG IL6 MMP9 NFKB1
20 12.25 IFNG IL10 IL6 NFKB1
21 12.25 CCL5 GATA3 IFNG IL10 IL2 IL2RA
22
Show member pathways
12.21 IFNG IFNL3 IL10 IL2 IL2RA IL6
23 12.2 IFNG IL6 MMP9 NFKB1
24 12.2 GATA3 IL10 IL6 NFKB1
25
Show member pathways
12.17 IFNG IL10 IL2 IL6
26 12.03 IFNG IL2 IL6 MMP9
27
Show member pathways
12.01 IL2 IL2RA NFKB1
28
Show member pathways
12 CCL5 CX3CR1 CXCR3
29 12 GATA3 IL10 IL6 MMP9
30
Show member pathways
12 IFNG IL2 IL2RA NFKB1
31
Show member pathways
11.99 GATA3 IFNG IL10 IL2 IL6
32 11.97 CCL5 IL6 MMP9 NFKB1
33 11.91 IFNG IL10 IL6 NFKB1
34 11.91 CX3CR1 IFNG IL10 IL2 IL2RA IL6
35 11.9 IFNG IL6 NFKB1
36 11.86 CCL5 IFNG IL6
37 11.85 GATA3 IFNG IL2 IL6 NFKB1
38 11.84 IFNG IL6 NFKB1
39 11.8 CX3CR1 IFNG IL10 IL2 IL6
40
Show member pathways
11.79 GATA3 IFNG IL2 IL2RA
41 11.78 IL10 IL6 NFKB1
42
Show member pathways
11.72 IL2 IL2RA NFKB1
43 11.72 IL10 IL2RA IL6 NFKB1 TNFRSF4
44 11.71 IFNG IL2 NFKB1
45 11.7 IL6 MMP9 NFKB1
46
Show member pathways
11.69 IFNG IL2 IL2RA TNFRSF4
47 11.68 CCL5 IL6 MMP9
48 11.68 IFNG IL10 IL2 IL2RA IL6
49 11.64 CXCR3 GATA3 IFNG IL10 IL2 IL2RA
50
Show member pathways
11.63 IFNG IL2 IL6 MMP9 NFKB1

GO Terms for Tropical Spastic Paraparesis

Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL5 IFNG IFNL3 IL10 IL2 IL6
2 neuron projection GO:0043005 9.56 CNTN2 CX3CR1 IFNG PTPN13
3 external side of plasma membrane GO:0009897 9.26 CXCR3 IFNG IL2RA IL6
4 extracellular space GO:0005615 9.17 CCL5 IFNG IFNL3 IL10 IL2 IL6

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 IL10 IL2 IL6 MMP9 NFKB1
2 response to drug GO:0042493 9.93 GATA3 IFNG IL10 IL6
3 cellular response to tumor necrosis factor GO:0071356 9.82 CCL5 GATA3 IL6
4 response to virus GO:0009615 9.81 CCL5 GATA3 IFNG
5 immune response GO:0006955 9.8 CCL5 IFNG IL10 IL2 IL2RA IL6
6 cellular response to interleukin-1 GO:0071347 9.75 CCL5 IL6 NFKB1
7 chemokine-mediated signaling pathway GO:0070098 9.74 CCL5 CX3CR1 CXCR3
8 cellular response to lipopolysaccharide GO:0071222 9.72 CX3CR1 IFNG IL10 IL6 NFKB1
9 inflammatory response GO:0006954 9.7 CCL5 CXCR3 IL10 IL2RA IL6 NFKB1
10 humoral immune response GO:0006959 9.69 GATA3 IFNG IL6
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 CCL5 IFNG IL2 IL6
12 positive regulation of JAK-STAT cascade GO:0046427 9.65 CCL5 IL6
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.65 IL10 MMP9
14 negative regulation of growth of symbiont in host GO:0044130 9.64 IFNG IL10
15 defense response to protozoan GO:0042832 9.63 IFNG IL10 IL6
16 cellular response to hepatocyte growth factor stimulus GO:0035729 9.62 IL10 IL6
17 macrophage chemotaxis GO:0048246 9.62 CCL5 CX3CR1
18 positive regulation of protein import into nucleus, translocation GO:0033160 9.61 IFNG IL6
19 positive regulation of T cell differentiation GO:0045582 9.61 GATA3 IL2 IL2RA
20 positive regulation of isotype switching to IgG isotypes GO:0048304 9.59 IFNG IL2
21 regulation of T cell activation GO:0050863 9.58 CCL5 IFNL3
22 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL2 IL6 TNFRSF4
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IFNG IL10
24 negative regulation of lymphocyte proliferation GO:0050672 9.54 IL2 IL2RA
25 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.52 GATA3 IL6
26 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
27 neutrophil apoptotic process GO:0001781 9.48 IFNG IL6
28 negative regulation of inflammatory response GO:0050728 9.35 GATA3 IL10 IL2 IL2RA NFKB1
29 positive regulation of T cell proliferation GO:0042102 9.02 CCL5 IFNG IL2 IL2RA IL6
30 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.08 GATA3 IFNG IL10 IL2 IL6 NFKB1
31 positive regulation of transcription, DNA-templated GO:0045893 10 GATA3 IFNG IL10 IL6 NFKB1

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL5 IFNG IFNL3 IL10 IL2 IL6
2 interleukin-2 receptor binding GO:0005134 8.96 GATA3 IL2

Sources for Tropical Spastic Paraparesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....